Multi-point sampler for dispersive gastric signet ring cell carcinoma tissues

Abstract

The invention discloses a multi-point sampler for dispersive gastric signet-ring cell carcinoma tissues. The multi-point sampler can be used for sampling the tissues at multiple points in the process of entering an endoscope channel at one time. Comprising an imbedding hose, a sampling head and an external operating handle, the sampling head is provided with a main shell, a sampling needle, a sample microcapsule, a sample suction pipeline and a needle part control structure; the main shell is provided with at least three needle placing channels and capsule cabins, the number of the capsule cabins is consistent with that of the needle placing channels, the needle placing channels extend to the surface of the end of the main shell to form a needle outlet, a sampling needle is arranged in each needle placing channel, and the needle part control structure controls any sampling needle to extend out of or retract into the needle placing channel; the capsule cabins are arranged around the main shell, a taking-out opening is formed in the side of the main shell, and a sample microcapsule is arranged in each capsule cabin; negative pressure pipes are arranged in the imbedding hose; and each negative pressure pipe, the sample microcapsule, the sample suction pipeline and the sampling needle are sequentially connected to form a group of sampling channels.

Description

Technical Field

[0001] This invention relates to the field of gastric cancer biopsy sampling instruments, specifically a multi-site sampler for diffuse gastric signet ring cell carcinoma tissue. Background Technology

[0002] Diffuse gastric signet ring cell carcinoma is a highly aggressive subtype of gastric cancer with a poor prognosis. Its cancer cells grow diffusely, often infiltrating the submucosa early and metastasizing extensively. Currently, endoscopic biopsy is the primary clinical method for sampling suspicious lesions. The standard procedure involves using disposable biopsy forceps, inserted through the working channel of the endoscope, to extract a single small tissue fragment under direct vision, which is then withdrawn along with the instrument. Each tissue sample represents the histological state of a specific location. However, for the diagnosis and evaluation of diffuse gastric signet ring cell carcinoma, a single biopsy sample has limitations: due to the uneven and widespread distribution of diffuse gastric signet ring cell carcinoma, in order to comprehensively assess the nature, extent, and heterogeneity of the lesion and perform necessary immunohistochemical or genetic testing, clinical practice often requires sampling from different areas of the lesion or from multiple suspicious sites within the stomach.

[0003] Under current technological conditions, obtaining a sample from each point requires completing a full cycle of "instrument insertion - positioning - clamping - instrument withdrawal - sample collection." When sampling from four or more points is needed, this process must be repeated multiple times. This results in cumbersome and time-consuming operations. Repeated insertion and withdrawal of the endoscope prolongs the overall endoscopic procedure, increases the physician's workload, extends the patient's pain and discomfort, and may increase anesthesia-related risks. Furthermore, during segmented and interval sampling, the lack of direct reference sampling points makes it difficult for physicians to accurately determine the rationality of the distribution of each sampling point. This may lead to missed sampling of some key lesions or duplicate sampling from different points, affecting the representativeness of the samples and the accuracy of the pathological diagnosis.

[0004] Therefore, is it possible to propose a solution that allows for sequential tissue retrieval at different pre-selected locations during a single entry into the endoscopic working channel, with all samples temporarily stored inside the instrument or in a specific carrier, and then removed from the body as a whole in a single procedure? This solution would not only improve surgical efficiency and reduce patient discomfort, but also ensure the systematic and planar nature of multi-point sampling, providing a more reliable and efficient means of obtaining pathological tissue for diseases requiring multi-regional evaluation, such as diffuse gastric cancer. Summary of the Invention

[0005] The purpose of this invention is to address the problems existing in the background art by providing a multi-site sampler for diffuse gastric signet ring cell carcinoma tissue, which can perform tissue sampling at multiple sites during a single entry into the endoscopic channel, and remove all samples simultaneously after completion, thereby improving the efficiency of endoscopic surgery.

[0006] To achieve the above-mentioned objectives, the present invention adopts the following technical solution: A multi-site sampler for diffuse gastric signet ring cell carcinoma tissue includes an insertion part that enters the body through an endoscopic biopsy channel and an external operating handle. The insertion part includes an insertion tube and a sampling head. The sampling head is connected to the front end of the insertion tube, and the rear end of the insertion tube is connected to the external operating handle. The sampling head is provided with a main shell, a sampling needle, a sample microcapsule, a sample aspiration tubing, and a needle control structure. The main housing has an arc-shaped end and at least three needle placement channels, as well as capsule chambers with the same number of needle placement channels. The needle placement channels are evenly arranged around the axis of the main housing and extend to the surface of the arc-shaped end to form a needle outlet. Each needle placement channel contains a sampling needle. A needle control structure is located in the main housing to control the extension or retraction of any sampling needle into the needle placement channel. The capsule chambers are evenly arranged around the axis of the main housing and form an extraction outlet on the side of the main housing. Each capsule chamber contains a sample microcapsule. The insertion tubing contains a negative pressure tube with the same number of sample microcapsules as the sample microcapsules, and the sample aspiration tubing also has the same number of sample microcapsules. Each negative pressure tube, sample microcapsule, sample aspiration tubing, and sampling needle are sequentially connected to form a sampling channel. The needle control structure is connected to a control circuit, and the control circuit and negative pressure tube extend through the insertion tubing and are connected to an external operating handle.

[0007] Preferably, the sampling needle has a needle cavity inside that connects to the sample aspiration tube, the front end of the sampling needle is provided with a tip for piercing the tissue, and an aspiration port is provided on the side of the sampling needle near the tip, the aspiration port connects to the needle cavity, and a toothed plate protruding towards the aspiration port is provided at the edge of the aspiration port near the tip; the sample microcapsule is a transparent shell, and a tissue baffle is provided inside the sample microcapsule near the negative pressure tube, the tissue baffle having a microporous structure that allows gas to pass through but obstructs the passage of solid tissue.

[0008] Preferably, the needle control structure provides a set of control parts for each sampling needle. The control parts include a sliding cavity, a slider, and a driving component for controlling the extension and retraction of the slider. The rear end of the sampling needle is fixedly connected to the slider. The sliding cavity is located at the inner end of the needle placement channel. The slider is slidably embedded in the sliding cavity, and the sliding direction of the slider is consistent with the axial direction of the needle placement channel. The sample aspiration tubing includes an elastic tube and a fixed tube. The fixed tube is built into the main housing and its two ends are respectively connected to the rear end of the sliding cavity and the capsule chamber. The elastic tube is located in the sliding cavity behind the slider. The front end of the elastic tube is connected to the slider. The rear end of the sampling needle passes through the slider and connects to the elastic tube. The rear end of the elastic tube is connected to the fixed tube.

[0009] Preferably, the driving component includes a permanent magnet part and an electromagnet part. The permanent magnet part is fixedly disposed on one end face of the slider, and the electromagnet part is fixedly disposed on the end face of the sliding cavity opposite to the permanent magnet part. The permanent magnet part is located within the magnetic attraction range of the electromagnet part, and the control circuit is connected to the electromagnet part to control the magnetic pole direction of the electromagnet part.

[0010] Preferably, the main housing is further provided with a fixed water bladder, which is arranged around the outer periphery of the main housing and is made of a flexible material; the fixed water bladder is connected to a water injection pipe, which passes through the main housing and the inserted hose in sequence and extends to the external operating handle.

[0011] Preferably, the capsule chamber includes a front end face and a rear end face. The front end face is provided with a convex interface seat I, and the rear end face is provided with a convex interface seat II. Both convex interface seats I and convex interface seats II are made of flexible and waterproof material. The sample aspiration tube is connected to the middle of the convex interface seat I, and the negative pressure tube is connected to the middle of the convex interface seat II. The front end of the sample microcapsule is provided with a recess I that fits the convex interface seat I, and the rear end of the sample microcapsule is provided with a recess II that fits the convex interface seat II. The recess I has an inlet for connecting to the sample aspiration tube, and the recess II has a channel for connecting to the negative pressure tube.

[0012] Preferably, an identification system is provided on the external operating handle and / or sampling head to distinguish and number each group of sampling channels. The identification system is set as a number identifier, letter identifier, graphic identifier, or color identifier.

[0013] Compared with existing technologies, the multi-site sampler for diffuse gastric signet ring cell carcinoma tissue using the above-mentioned technical solution has the following beneficial effects: I. This solution incorporates multiple sampling needles, along with matching sample microcapsules and suction tubing, into the sampling head. During sampling, a suitable negative pressure is applied to draw the sample tissue into the microcapsules for temporary storage. The sampling head, integrated with the existing endoscopic system's working head, can reach multiple sampling points, enabling sampling at multiple locations within a single entry into the body. After all sampling is complete, the tissue samples stored in the multiple microcapsules are simultaneously removed, eliminating the need for multiple "entry-exit" operations. This improves surgical efficiency, reduces patient discomfort, and enhances the accuracy of the surgeon's assessment of sampling point distribution.

[0014] Second, the extension and retraction of each sampling needle can be independently controlled via magnetic control. By controlling the direction of the electromagnet's poles, in conjunction with the permanent magnet connected to the slider, the pushing and retracting of the sampling needles can be achieved. This method maintains ease of operation and control stability even in a small and delicate structure.

[0015] 3. An aspiration port is set on the side of the sampling needle tip. After the sampling needle is inserted into the tissue, a small amount of tissue is brought into the needle cavity by negative pressure. The toothed plate protruding towards the aspiration port on the front edge can hook the tissue when the needle is withdrawn, so as to facilitate the separation and removal of the tissue and ensure that the tissue is smoothly drawn into the sample microcapsule.

[0016] IV. The sample microcapsules are detachably installed in the capsule chamber, and the fitting of the concave ends with the convex interface seats facilitates installation and sorting operations. When installing the sample microcapsules, the soft and elastic convex interface seats can be embedded in the concave ends and squeeze the surface of the concave ends to keep the sample microcapsules fixed in the capsule chamber and ensure the sealing at the interface. After sampling is completed and the entire sampler is removed, it is convenient to remove each sample microcapsule for testing. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the structure of an embodiment of the multi-site sampler for diffuse gastric signet ring cell carcinoma tissue according to the present invention.

[0018] Figure 2 This is a cross-sectional view of the inserted tubing in this embodiment.

[0019] Figure 3 This is a schematic diagram of the sampling head in this embodiment.

[0020] Figure 4 This is a schematic diagram of the sampling needle in this embodiment.

[0021] Figure 5 This is a schematic diagram of the cross-sectional structure of the sampling head in this embodiment.

[0022] Figure 6 and Figure 7 This is a schematic diagram illustrating the connection between the sample microcapsule and the capsule chamber in this embodiment.

[0023] Reference numerals: 1. Insertion part; 2. External operating handle; 3. Insertion tubing; 30. Negative pressure tube; 4. Sampling head; 40. Main shell; 400. Arc end; 401. Needle outlet; 402. Capsule chamber; 402-1. Convex interface seat I; 402-2. Convex interface seat II; 41. Sampling needle; 410. Tip; 411. Needle cavity; 412. Suction port; 413. Toothed plate; 42. Sample microcapsule; 42-1. Recess I; 42-2. Recess II; 43. Sample suction tubing; 430. Elastic tube; 431. Fixing tube; 44. Needle insertion channel; 45. Needle control structure; 450. Sliding cavity; 451. Sliding block; 452. Permanent magnet part; 453. Electromagnet part; 454. Control circuit; 46. Fixing water bladder; 460. Water injection tubing. Detailed Implementation

[0024] To further illustrate the technical means and effects of the present invention in achieving its intended purpose, the following detailed description of the specific implementation methods, structures, features, and effects of the present invention, in conjunction with the accompanying drawings and preferred embodiments, is provided below.

[0025] like Figures 1 to 7 The multi-site sampling device for diffuse gastric signet ring cell carcinoma tissue shown includes an insertion part 1 that enters the body through the endoscopic biopsy channel and an external operating handle 2. The insertion part 1 includes an insertion tube 3 and a sampling head 4. The sampling head 4 is connected to the front end of the insertion tube 3, and the rear end of the insertion tube 3 is connected to the external operating handle 2. The external operating handle 2 has a built-in controller and may also have a built-in negative pressure pump and a micro-liquid pump; the specific configuration can be designed according to actual usage requirements.

[0026] The sampling head 4 is provided with a main shell 40, a sampling needle 41, a sample microcapsule 42, a sample aspiration tubing 43, and a needle control structure 45.

[0027] The main housing 40 has an arc-shaped end 400 at one end and four needle placement channels 44 and four capsule chambers 402. The needle placement channels 44 are evenly arranged around the axis of the main housing 40 and extend to the surface of the arc-shaped end 400 to form a needle outlet 401. Each needle placement channel 44 contains a sampling needle 41. The sampling needle 41 has a needle cavity 411 inside and a tip 410 for piercing tissue at its front end. A suction port 412 is provided on the side of the sampling needle 41 near the tip 410, which connects to the needle cavity 411. A toothed plate 413 protruding towards the suction port 412 is provided at the edge of the suction port 412 near the tip 410. A needle control structure 45 is provided in the main housing 40 to control the extension or retraction of any sampling needle 41 into the needle placement channel 44. The needle control structure 45 is provided with a set of control parts for each sampling needle 41. The control parts include a sliding cavity 450, a slider 451 and a driving component for controlling the extension and retraction of the slider 451. The rear end of the sampling needle 41 is fixedly connected to the slider 451. The sliding cavity 450 is located at the inner end of the needle placement channel 44. The slider 451 is slidably embedded in the sliding cavity 450, and the sliding direction of the slider 451 is consistent with the axial direction of the needle placement channel 44. The driving component includes a permanent magnet part 452 and an electromagnet part 453. The permanent magnet part 452 is fixedly disposed on the front end face of the slider 451, and the electromagnet part 453 is fixedly disposed on the end face of the slide cavity 450 opposite to the permanent magnet part 452, i.e., the front end face of the slide cavity 450. The permanent magnet part 452 is located within the magnetic attraction range of the electromagnet part 453. The electromagnet part 453 is connected to a control circuit 454. The control circuit 454 extends in the insertion hose 3 and is connected to an external operating handle 2. The direction of the magnetic poles of the electromagnet part 453 is controlled by the external operating handle 2. When the magnetic poles of the electromagnet part 453 are opposite to those of the facing permanent magnet part 452, the slider 451 is attracted to the front end, causing the sampling needle 41 to extend from the needle outlet 401, at which point sampling can be performed; when the magnetic poles of the electromagnet part 453 are the same as those of the facing permanent magnet part 452, the slider 451 is repelled and slides to the rear end, causing the sampling needle 41 to retract into the needle outlet 401.

[0028] Capsule chambers 402 are evenly arranged around the axis of the main shell 40, and an extraction port is formed on the side of the main shell 40. Each capsule chamber 402 contains one sample microcapsule 42. The insertion tubing 3 is provided with four negative pressure tubes 30, which extend in the insertion tubing 3 and are connected to the external operating handle 2; and there are also four sample aspiration tubing 43. Each negative pressure tube 30, sample microcapsule 42, sample aspiration tubing 43 and sampling needle 41 are connected in sequence to form a set of sampling channels.

[0029] The sample aspiration tubing 43 includes an elastic tube 430 and a fixed tube 431. The fixed tube 431 is built into the main housing 40 and its two ends are respectively connected to the rear end of the sliding cavity 450 and the capsule chamber 402. The elastic tube 430 is located in the sliding cavity 450 behind the slider 451. The front end of the elastic tube 430 is connected to the slider 451. The rear end of the sampling needle 41 passes through the slider 451 and connects to the elastic tube 430. That is, the needle cavity 411 of the sampling needle 41 is connected to the sample aspiration tubing 43. The rear end of the elastic tube 430 is connected to the fixed tube 431.

[0030] The sample microcapsule 42 is configured as a transparent shell, and a tissue baffle is provided at one end of the sample microcapsule 42 near the negative pressure tube 30. The tissue baffle has a microporous structure that allows gas to pass through but prevents solid tissue from passing through. The capsule chamber 402 includes a front end face and a rear end face. The front end face is provided with a convex interface seat I 402-1, and the rear end face is provided with a convex interface seat II 402-2. Both convex interface seats I 402-1 and convex interface seats II 402-2 are made of flexible and waterproof material. The sample suction tube 43 is connected to the middle of the convex interface seat I 402-1, and the negative pressure tube 30 is connected to the middle of the convex interface seat II 402-2. The front end of the sample microcapsule 42 is provided with a recess I 42-1 that is adapted to the convex interface seat I 402-1, and the rear end of the sample microcapsule 42 is provided with a recess II 42-2 that is adapted to the convex interface seat II 402-2. The recess I 42-1 has an inlet for connecting to the sample suction tube 43, and the recess II 42-2 has a channel for connecting to the negative pressure tube 30.

[0031] The main housing 40 is also provided with a fixed water bladder 46, which is arranged around the outer periphery of the main housing 40 and is made of a flexible material. The fixed water bladder 46 is connected to a water injection pipe 460, which passes through the main housing 40 and the insertion hose 3 in sequence and extends to the external operating handle 2. The external operating handle 2 controls the micro liquid pump to inject water into the water injection pipe 460, so that the fixed water bladder 46 expands and is squeezed and fixed to the inner wall of the end of the working channel.

[0032] An identification system is set on the external operating handle 2 and / or sampling head 4 to distinguish and number each group of sampling channels. The identification system is set as a number, letter, graphic or color identifier (not shown in the figure).

[0033] Specific operating instructions: 1. Insert the insertion tube 3 and sampling head 4 into the biopsy channel of the endoscope system, so that the sampling head 4 reaches the end of the endoscope cannula; 2. Operate the external operating handle 2 to inflate the water-fixing bladder 46 with water, and the water-fixing bladder 46 will compress the inner wall of the biopsy channel to complete the fixation of the sampling head 4; 3. Operate the endoscope control handle to adjust the orientation of the endoscope cannula tip so that the sampling head 4 reaches one of its target areas; 4. Operate the external operating handle 2 to extend one of its sampling needles 41. After piercing the tissue, control the negative pressure tube 30 to generate negative pressure, so that the tissue is drawn into the needle cavity 411 of the sampling needle 41. Then, the sampling needle 41 is withdrawn and the tissue is separated. The tissue sample is drawn into the sample microcapsule 42 for temporary storage. 5. Repeat the previous step to complete the sampling operation of other sampling channels until all sample microcapsules 42 contain tissue samples; 6. Withdraw the insertion tube 3 and sampling head 4 from the biopsy channel of the endoscope, and remove the sample microcapsule 42 for testing.

[0034] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present invention. Any simple modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. A multipoint sampler for diffuse signet ring cell carcinoma tissue, comprising an insertion part (1) for access into the body through an endoscopic biopsy channel and an external operating handle (2), characterized in that: The implanting part (1) comprises an implanting hose (3) and a sampling head (4), the sampling head (4) is connected to the front end of the implanting hose (3), and the rear end of the implanting hose (3) is connected to the external operating handle (2); the sampling head (4) is provided with a main shell (40), a sampling needle (41), a sample microcapsule (42), a sample suction pipeline (43) and a needle part control structure (45); The end of the main shell (40) is provided with a circular arc end head (400), the main shell (40) is provided with at least three needle placing channels (44) and capsule cabins (402) consistent in number with the needle placing channels (44), the needle placing channels (44) are uniformly arranged around the axis of the main shell (40), the needle placing channels (44) extend to the surface of the circular arc end head (400) to form needle outlets (401), one sampling needle (41) is arranged in each needle placing channel (44), and the needle part control structure (45) is arranged in the main shell (40) to respectively control any sampling needle (41) to extend out of or retract into the needle placing channel (44); the capsule cabins (402) are uniformly arranged around the axis of the main shell (40), the capsule cabins (402) form sample outlets on the side of the main shell (40), and one sample microcapsule (42) is arranged in each capsule cabin (402); The implanting hose (3) is provided with negative pressure pipes (30) consistent in number with the sample microcapsules (42), and the sample suction pipelines (43) are consistent in number with the sample microcapsules (42), one negative pressure pipe (30), one sample microcapsule (42), one sample suction pipeline (43) and one sampling needle (41) are sequentially connected to form a group of sampling channels; the needle part control structure (45) is connected with a control line (454), and the control line (454) and the negative pressure pipes (30) extend in the implanting hose (3) and are connected to the external operating handle (2).

2. The multipoint sampler for diffuse signet ring cell carcinoma tissue of claim 1, wherein: The sampling needle (41) is internally provided with a needle cavity (411) communicated with the sample suction pipeline (43), the front end of the sampling needle (41) is provided with a pointed end (410) for penetrating into tissue, the side of the sampling needle (41) close to the pointed end (410) is provided with a suction inlet (412) communicated with the needle cavity (411), and the edge of the suction inlet (412) close to the pointed end (410) is provided with a tooth-shaped piece (413) protruding towards the suction inlet (412); the sample microcapsule (42) is provided as a transparent shell, one end of the sample microcapsule (42) close to the negative pressure pipe (30) is provided with a tissue baffle, and the tissue baffle has a microporous structure allowing gas to pass through but impeding solid tissue from passing through.

3. The multipoint sampler for diffuse signet ring cell carcinoma tissue of claim 1, wherein: The needle part control structure (45) is provided with a set of control parts for each sampling needle (41), the control parts include a sliding cavity (450), a sliding block (451) and a driving part for controlling the sliding block (451) to slide, the rear end of the sampling needle (41) is fixedly connected to the sliding block (451), the sliding cavity (450) is located at the inner end of the needle placing channel (44), the sliding block (451) is slidably embedded in the sliding cavity (450), and the sliding direction of the sliding block (451) is consistent with the axial direction of the needle placing channel (44); the sample suction pipeline (43) includes an elastic tube body (430) and a fixed pipeline (431), the fixed pipeline (431) is built-in in the main shell (40) and connected to the rear end of the sliding cavity (450) and the capsule cabin (402) at both ends respectively, the elastic tube body (430) is located in the sliding cavity (450) behind the sliding block (451), the front end of the elastic tube body (430) is connected to the sliding block (451), the rear end of the sampling needle (41) penetrates through the sliding block (451) and is connected to the elastic tube body (430), and the rear end of the elastic tube body (430) is connected to the fixed pipeline (431).

4. The multipoint sampler for diffuse signet ring cell carcinoma tissue of claim 3, wherein: The driving part includes a permanent magnet part (452) and an electromagnet part (453), the permanent magnet part (452) is fixedly arranged on one end face of the sliding block (451), the electromagnet part (453) is fixedly arranged on the end face of the sliding cavity (450) opposite to the permanent magnet part (452), the permanent magnet part (452) is located in the magnetic attraction range of the electromagnet part (453), and a control line (454) is connected to the electromagnet part (453) to control the pole direction of the electromagnet part (453).

5. The multipoint sampler for diffuse signet ring cell carcinoma tissue of claim 1, wherein: The main shell (40) is further provided with a fixed water bag (46), the fixed water bag (46) is arranged around the outer periphery of the main shell (40), and the fixed water bag (46) is made of a flexible and elastic material; the fixed water bag (46) is connected with a water injection pipeline (460), the water injection pipeline (460) extends to an external operating handle (2) after penetrating through the main shell (40) and a placed hose (3) in sequence.

6. The multipoint sampler for diffuse signet ring cell carcinoma tissue of claim 1, wherein: The capsule cabin (402) includes a front end face and a rear end face, the front end face is provided with a convex interface seat I (402-1), the rear end face is provided with a convex interface seat II (402-2), the convex interface seat I (402-1) and the convex interface seat II (402-2) are both made of a flexible and elastic waterproof material, the sample suction pipeline (43) is connected to the middle part of the convex interface seat I (402-1), and the negative pressure pipe (30) is connected to the middle part of the convex interface seat II (402-2); the front end part of the sample microcapsule (42) is provided with a concave part I (42-1) matched with the convex interface seat I (402-1), the rear end part of the sample microcapsule (42) is provided with a concave part II (42-2) matched with the convex interface seat II (402-2), the concave part I (42-1) has an inlet matched with the sample suction pipeline (43), and the concave part II (42-2) has a channel port matched with the negative pressure pipe (30).

7. The multipoint sampler for diffuse signet ring cell carcinoma tissue of claim 1, wherein: An identification system is provided on the external operating handle (2) and / or the sampling head (4) to distinguish each group of sampling channels, which is provided as a numerical identification, an alphabetical identification, a graphical identification or a color identification.

Images