Whitening, spot-fading and repairing essence containing tranexamic acid and preparation method of whitening, spot-fading and repairing essence
Through the synergistic effect of ingredients such as tranexamic acid and modified chitosan, the problems of stratum corneum exfoliation and poor absorption in existing whitening skin care products have been solved, achieving the effects of whitening and fading spots, moisturizing and anti-inflammation, and improving skin condition.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-26
- Publication Date
- 2026-03-17
AI Technical Summary
Alpha-hydroxy acids in existing whitening skincare products cause the stratum corneum to peel off more quickly, affecting appearance, and the absorption of nutrients is poor, making it difficult to achieve effective skincare.
By utilizing the synergistic effects of ingredients such as tranexamic acid, α-arbutin, and modified chitosan, it blocks melanin formation by inhibiting tyrosinase activity, combines licorice extract to inhibit the production of inflammatory factors, and increases skin hydration. It uses safe cosmetic ingredients and avoids preservatives to achieve whitening, spot-fading, and moisturizing effects.
It achieves whitening and spot-fading effects, moisturizes and reduces inflammation, enhances the skin's antioxidant capacity and immunity, improves skin condition, and keeps skin moisturized and supple for a long time.
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Abstract
Description
Technical Field
[0001] This invention relates to the field of cosmetic technology, specifically to a whitening and spot-fading repairing essence containing tranexamic acid and its preparation method. Background Technology
[0002] With the increasing number of "acid-exfoliating" products on the market, there is a growing number of whitening formulas containing weakly acidic systems of α-hydroxy acids or β-hydroxy acids such as glycolic acid, lactic acid, malic acid, tartaric acid, and salicylic acid. After use, the stratum corneum of the skin will peel off more quickly, thus affecting the appearance. Essences have the effects of lifting and firming, moisturizing, reducing wrinkles, and promoting cell regeneration, keeping the skin in better condition. At present, the nutrient molecules in common water, lotion, and face cream are relatively large, and their absorption and penetration are insufficient, making it difficult to achieve the skin care effect. Summary of the Invention
[0003] (a) Technical problems to be solved To address the shortcomings of existing technologies, this invention provides a whitening and spot-fading repairing essence containing tranexamic acid and its preparation method, which has good whitening, spot-fading, repairing and moisturizing effects.
[0004] (II) Technical Solution To achieve the above objectives, the present invention provides the following technical solution: a whitening and spot-fading repairing essence containing tranexamic acid, comprising the following weight components: 3-10 parts by weight of tranexamic acid, 1-4 parts by weight of α-arbutin, 0.01-1 part by weight of carboxymethyl deacetylated chitosan, 0.5-1.5 parts by weight of Bifida ferment lysate, 0.02-0.04 parts by weight of 1,2-hexanediol, and 0.01-0.0... 3 parts by weight of p-hydroxyacetophenone, 0.05-5 parts by weight of glycyrrhizin, 2-3 parts by weight of humectant, 0.05-0.5 parts by weight of carbomer, 0.02-0.1 parts by weight of disodium EDTA, 0.05-0.5 parts by weight of arginine, C12-15 alkanol polyether-12, 0.02-0.2 PEG-40 hydrogenated castor oil, 1-2 parts by weight of modified chitosan, and 6-8 parts by weight of water.
[0005] Preferably, the humectant is: 0.05-5 parts by weight of betaine, 1-3 parts by weight of 1,2-hexanediol, 0.05-4 parts by weight of extracellular polysaccharide, and 0.05-4 parts by weight of bis-diethoxydiethylene glycol cyclohexane 1,4-dicarboxylic acid ester.
[0006] Preferably, the modified chitosan is prepared by: (1) Add 10-12 parts by weight of chitosan and 8-16 parts by weight of ε-caprolactone to a stirrer and stir evenly. Then add 0.1-0.3 parts by weight of stannous octoate catalyst, purge with nitrogen for protection, and react at 120-140℃ for 6-10h. After the reaction is complete, dissolve the crude product with chloroform and then precipitate with anhydrous diethyl ether. Repeat the dissolution and precipitation 3-4 times. Dry the product under vacuum to obtain caprolactone-modified chitosan. (2) Add 7-12 parts by weight of chitosan to deionized water to dissolve it, heat it in a water bath at 70-85°C, add 6-10 parts by weight of 2,3-epoxypropyltrimethylammonium chloride under constant pressure, react for 4-6 hours, wash after reaction, and dry under vacuum to obtain quaternized chitosan. (3) Glycine-arginine-glycine-aspartic acid-serine pentapeptide and taurine are dissolved simultaneously in a sodium bicarbonate solution with a concentration of 0.4-0.6 mol / L. The mixture is then placed in an ice-water bath, and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride is added. The mixture is stirred at 3-5℃ for 15-25 min and then removed. The mixture is then dialyzed and dried to obtain the intermediate. (4) Add quaternized chitosan and intermediate to N,N-dimethylformamide solvent, stir and disperse, continue to add p-toluenesulfonic acid catalyst, react at 70-80℃ for 5-7h, after which distill under reduced pressure, filter and dry to obtain modified chitosan.
[0007] Preferably, the mass ratio of glycine-arginine-glycine-aspartic acid-serine pentapeptide, taurine, and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride in (3) is 1:2.2-2.6:1.4-2.3.
[0008] Preferably, the mass ratio of quaternized chitosan, intermediate, and p-toluenesulfonic acid catalyst in (4) is 1.2-1.4:1:0.02-0.03.
[0009] Preferably, the preparation method of the whitening and spot-fading repair essence containing tranexamic acid includes the following steps: Phase A raw materials: purified water, carbomer, disodium EDTA, humectant; Phase B raw materials: 1,2-hexanediol, carboxymethyl deacetylated chitosan; Phase C raw material: Arginine; D-phase raw materials: tranexamic acid, α-arbutin, Bifida ferment lysate, p-hydroxyacetophenone, and glycyrrhizin; E-phase raw materials: C12-15 alkanol polyether-12, PEG-40 hydrogenated castor oil, modified chitosan; S1. Add phase A to the main tank in sequence, soak and dissolve, then stir and heat to 80-85℃; S2. After mixing and dispersing phase B evenly, add it to the main tank, stir and keep warm for 30 minutes until completely dissolved; S3. Pre-dissolve phase C at a temperature of 60-70℃. After complete dissolution, add it to the main tank and stir to cool it down to 40-45℃. S4. After the D phase raw material is completely dissolved, add it to the main tank and stir until completely dissolved; S5. After the E-phase raw materials are premixed evenly, add them to the main tank and stir evenly; S6. Stop stirring, take samples to test physicochemical and microbial indicators, and discharge the product after the physicochemical indicators are qualified to obtain the whitening and spot-fading repair essence containing tranexamic acid.
[0010] (iii) Beneficial technical effects The whitening and spot-fading essence provided by this invention uses only safe cosmetic raw materials, contains no preservatives, is gentle and non-irritating, has good whitening and spot-fading effects, and also has a good anti-inflammatory effect. Under the synergistic effect of tranexamic acid, α-arbutin, and bifida ferment lysate, the whitening and spot-fading components can quickly penetrate the skin, inhibiting the transfer of melanosomes, thereby achieving the whitening and spot-fading effect. Tranexamic acid inhibits the activity of tyrosinase, effectively blocking the formation of melanin, reducing pigment deposition, accelerating the decomposition and excretion of melanin, maintaining the skin's moisture and suppleness for a long time, activating skin cells, and improving the skin's antioxidant capacity, thus achieving the whitening and spot-fading effect. Licorice extract inhibits the production of inflammatory factors, thereby improving the skin's anti-inflammatory ability and antioxidant capacity. Chitosan can repair the skin and mucous membranes, increase the moisture of the skin surface, and long-term use can improve skin immunity. After peptide modification, the amino acids it contains also have a good protective and repairing effect on the skin. It also contains a small amount of quaternary ammonium salt, which can also play a bactericidal role. Detailed Implementation
[0011] Example 1 A whitening and spot-fading repairing essence containing tranexamic acid comprises the following components by weight: 3 parts tranexamic acid, 1 part α-arbutin, 0.01 parts carboxymethyl deacetylated chitosan, 0.5 parts Bifida ferment lysate, 0.02 parts 1,2-hexanediol, 0.01 parts p-hydroxyacetophenone, 0.05 parts glycyrrhizin, 2 parts moisturizer, 0.05 parts carbomer, 0.02 parts disodium EDTA, 0.05 parts arginine, C12-15 alkanol polyether-12, 0.02 parts PEG-40 hydrogenated castor oil, 1 part modified chitosan, and 6 parts water.
[0012] The humectant is: 0.05 parts by weight of betaine, 1 part by weight of 1,2-hexanediol, 0.05 parts by weight of extracellular polysaccharide, and 0.05 parts by weight of bis-diethoxydiethylene cyclohexane 1,4-dicarboxylic acid ester.
[0013] The method for preparing the modified chitosan is as follows: (1) Add 10 parts by weight of chitosan and 8 parts by weight of ε-caprolactone to a stirrer and stir evenly. Then add 0.1 parts by weight of stannous octoate catalyst, purge with nitrogen for protection, and react at 120°C for 6 hours. After the reaction is complete, dissolve the crude product with chloroform and then precipitate with anhydrous ether. Repeat the dissolution and precipitation 3-4 times. Dry the product under vacuum to obtain caprolactone-modified chitosan. (2) Add 7 parts by weight of chitosan to deionized water to dissolve it, heat it in a water bath at 70°C, add 6 parts by weight of 2,3-epoxypropyltrimethylammonium chloride under constant pressure, react for 4 hours, wash after reaction, and dry under vacuum to obtain quaternized chitosan. (3) Glycine-arginine-glycine-aspartic acid-serine pentapeptide and taurine were simultaneously dissolved in a 0.4 mol / L sodium bicarbonate solution. The mixture was then placed in an ice-water bath, and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride was added. The mass ratio of glycine-arginine-glycine-aspartic acid-serine pentapeptide, taurine, and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride was 1:2.2:1.4. The mixture was stirred at 3°C for 15 min and then removed. The mixture was then dialyzed and dried to obtain the intermediate. (4) Add quaternized chitosan and intermediate to N,N-dimethylformamide solvent, stir and disperse, and continue to add p-toluenesulfonic acid catalyst, wherein the mass ratio of quaternized chitosan, intermediate and p-toluenesulfonic acid catalyst is 1.2:1:0.02. React at 70℃ for 5h, and after the reaction is completed, distill under reduced pressure, filter and dry to obtain modified chitosan; The preparation method of the whitening and spot-fading repair essence containing tranexamic acid includes the following steps: Phase A raw materials: purified water, carbomer, disodium EDTA, humectant; Phase B raw materials: 1,2-hexanediol, carboxymethyl deacetylated chitosan; Phase C raw material: Arginine; D-phase raw materials: tranexamic acid, α-arbutin, Bifida ferment lysate, p-hydroxyacetophenone, and glycyrrhizin; E-phase raw materials: C12-15 alkanol polyether-12, PEG-40 hydrogenated castor oil, modified chitosan; S1. Add phase A sequentially to the main tank, soak and dissolve, then stir and heat to 80℃; S2. After mixing and dispersing phase B evenly, add it to the main tank, stir and keep warm for 30 minutes until completely dissolved; S3. Pre-dissolve phase C at 60°C. After complete dissolution, add it to the main tank and stir to cool it down to 40°C. S4. After the D phase raw material is completely dissolved, add it to the main tank and stir until completely dissolved; S5. After the E-phase raw materials are premixed evenly, add them to the main tank and stir evenly; S6. Stop stirring, take samples to test physicochemical and microbial indicators, and discharge the product after the physicochemical indicators are qualified to obtain the whitening and spot-fading repair essence containing tranexamic acid.
[0014] Example 2 A whitening and spot-fading repairing essence containing tranexamic acid comprises the following components by weight: 10 parts by weight of tranexamic acid, 4 parts by weight of α-arbutin, 1 part by weight of carboxymethyl deacetylated chitosan, 1.5 parts by weight of Bifida ferment lysate, 0.04 parts by weight of 1,2-hexanediol, 0.03 parts by weight of p-hydroxyacetophenone, 5 parts by weight of glycyrrhizin, 3 parts by weight of moisturizer, 0.5 parts by weight of carbomer, 0.1 parts by weight of disodium EDTA, 0.5 parts by weight of arginine, C12-15 alkanol polyether-12, 0.2 parts by weight of PEG-40 hydrogenated castor oil, 2 parts by weight of modified chitosan, and 8 parts by weight of water.
[0015] The humectant is: 5 parts by weight of betaine, 3 parts by weight of 1,2-hexanediol, 4 parts by weight of extracellular polysaccharide, and 4 parts by weight of bis-diethoxydiethylene glycol cyclohexane 1,4-dicarboxylic acid ester.
[0016] The method for preparing the modified chitosan is as follows: (1) Add 12 parts by weight of chitosan and 16 parts by weight of ε-caprolactone to a stirrer and stir evenly. Then add 0.3 parts by weight of stannous octoate catalyst, purge with nitrogen for protection, and react at 140°C for 10 h. After the reaction is complete, dissolve the crude product with chloroform and then precipitate with anhydrous diethyl ether. Repeat the dissolution and precipitation 4 times. Dry the product under vacuum to obtain caprolactone-modified chitosan. (2) Add 12 parts by weight of chitosan to deionized water to dissolve it, heat it in a water bath at 85°C, add 10 parts by weight of 2,3-epoxypropyltrimethylammonium chloride under constant pressure, react for 6 hours, wash after reaction, and dry under vacuum to obtain quaternized chitosan. (3) Glycine-arginine-glycine-aspartic acid-serine pentapeptide and taurine were simultaneously dissolved in a 0.6 mol / L sodium bicarbonate solution. The mixture was then placed in an ice-water bath, and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride was added. The mass ratio of glycine-arginine-glycine-aspartic acid-serine pentapeptide, taurine, and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride was 1:2.6:2.3. The mixture was stirred at 5°C for 25 min and then removed. The mixture was then dialyzed and dried to obtain the intermediate. (4) Add quaternized chitosan and intermediate to N,N-dimethylformamide solvent, stir and disperse, and continue to add p-toluenesulfonic acid catalyst, wherein the mass ratio of quaternized chitosan, intermediate and p-toluenesulfonic acid catalyst is 1.4:1:0.03. React at 80℃ for 7h, and after the reaction is completed, distill under reduced pressure, filter and dry to obtain modified chitosan; The preparation method of the whitening and spot-fading repair essence containing tranexamic acid includes the following steps: Phase A raw materials: purified water, carbomer, disodium EDTA, humectant; Phase B raw materials: 1,2-hexanediol, carboxymethyl deacetylated chitosan; Phase C raw material: Arginine; D-phase raw materials: tranexamic acid, α-arbutin, Bifida ferment lysate, p-hydroxyacetophenone, and glycyrrhizin; E-phase raw materials: C12-15 alkanol polyether-12, PEG-40 hydrogenated castor oil, modified chitosan; S1. Add phase A to the main tank in sequence, soak and dissolve, then stir and heat to 85°C; S2. After mixing and dispersing phase B evenly, add it to the main tank, stir and keep warm for 30 minutes until completely dissolved; S3. Pre-dissolve phase C at 70°C. After complete dissolution, add it to the main tank and stir to cool it down to 45°C. S4. After the D phase raw material is completely dissolved, add it to the main tank and stir until completely dissolved; S5. After the E-phase raw materials are premixed evenly, add them to the main tank and stir evenly; S6. Stop stirring, take samples to test physicochemical and microbial indicators, and discharge the product after the physicochemical indicators are qualified to obtain the whitening and spot-fading repair essence containing tranexamic acid.
[0017] Example 3 A whitening and spot-fading repairing essence containing tranexamic acid comprises the following components by weight: 7 parts tranexamic acid, 2.5 parts α-arbutin, 0.5 parts carboxymethyl deacetylated chitosan, 1 part Bifida ferment lysate, 0.3 parts 1,2-hexanediol, 0.2 parts p-hydroxyacetophenone, 2.5 parts glycyrrhizin, 2.5 parts moisturizer, 0.27 parts carbomer, 0.06 parts disodium EDTA, 0.27 parts arginine, C12-15 alkanol polyether-12, 0.11 parts PEG-40 hydrogenated castor oil, 1.5 parts modified chitosan, and 7 parts water.
[0018] The humectant is: 0.27 parts by weight of betaine, 2 parts by weight of 1,2-hexanediol, 0.22 parts by weight of extracellular polysaccharide, and 0.22 parts by weight of bis-diethoxydiethylene cyclohexane 1,4-dicarboxylic acid ester.
[0019] The method for preparing the modified chitosan is as follows: (1) Add 11 parts by weight of chitosan and 12 parts by weight of ε-caprolactone to a stirrer and stir evenly. Then add 0.2 parts by weight of stannous octoate catalyst, purge with nitrogen for protection, and react at 130°C for 8 hours. After the reaction is complete, dissolve the crude product with chloroform and precipitate with anhydrous ether. Repeat the dissolution and precipitation three times. Dry the product under vacuum to obtain caprolactone-modified chitosan. (2) Add 9.5 parts by weight of chitosan to deionized water to dissolve it, heat it in a water bath at 77°C, add 8 parts by weight of 2,3-epoxypropyltrimethylammonium chloride under constant pressure, react for 5 hours, wash after reaction, and dry under vacuum to obtain quaternized chitosan. (3) Glycine-arginine-glycine-aspartic acid-serine pentapeptide and taurine were simultaneously dissolved in a 0.5 mol / L sodium bicarbonate solution. The mixture was then placed in an ice-water bath, and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride was added. The mass ratio of glycine-arginine-glycine-aspartic acid-serine pentapeptide, taurine, and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride was 1:2.4:1.85. The mixture was stirred at 4°C for 20 min and then removed. The mixture was then dialyzed and dried to obtain the intermediate. (4) Add quaternized chitosan and intermediate to N,N-dimethylformamide solvent, stir and disperse, and continue to add p-toluenesulfonic acid catalyst, wherein the mass ratio of quaternized chitosan, intermediate and p-toluenesulfonic acid catalyst is 1.3:1:0.025. React at 75℃ for 6h, and after the reaction is completed, distill under reduced pressure, filter and dry to obtain modified chitosan; The preparation method of the whitening and spot-fading repair essence containing tranexamic acid includes the following steps: Phase A raw materials: purified water, carbomer, disodium EDTA, humectant; Phase B raw materials: 1,2-hexanediol, carboxymethyl deacetylated chitosan; Phase C raw material: Arginine; D-phase raw materials: tranexamic acid, α-arbutin, Bifida ferment lysate, p-hydroxyacetophenone, and glycyrrhizin; E-phase raw materials: C12-15 alkanol polyether-12, PEG-40 hydrogenated castor oil, modified chitosan; S1. Add phase A sequentially to the main tank, soak and dissolve, then stir and heat to 82.5℃; S2. After mixing and dispersing phase B evenly, add it to the main tank, stir and keep warm for 30 minutes until completely dissolved; S3. Pre-dissolve phase C at 65℃. After complete dissolution, add it to the main tank and stir to cool it down to 42.5℃. S4. After the D phase raw material is completely dissolved, add it to the main tank and stir until completely dissolved; S5. After the E-phase raw materials are premixed evenly, add them to the main tank and stir evenly; S6. Stop stirring, take samples to test physicochemical and microbial indicators, and discharge the product after the physicochemical indicators are qualified to obtain the whitening and spot-fading repair essence containing tranexamic acid.
[0020] Comparative Example 1 The difference between this comparative example and Example 3 is that no modified chitosan was added.
[0021] Eighty participants aged 20-45 were randomly selected and divided into four groups of 20 each. All four groups used the whitening and spot-fading repair serums described in Examples 1 to 3, twice daily (morning and evening) for 30 days. Skin hydration was measured using a Corneometer CM825 on days 0 and 30 to assess skin hydration before and after using the whitening and spot-fading repair serums.
[0022] The results of the moisturizing efficacy test are shown in Table 1.
[0023] Table 1: Skin moisture content test.
[0024]
[0025] As shown in Table 1, Examples 1-3 have better moisturizing effects compared to Comparative Example 1.
[0026] The quantitative skin color measurement method used is the Lab colorimetric system specified by the International Commission on Illumination (CIE). This method provides relatively accurate quantification, reflects multidimensional changes in skin color space, and makes skin color quantification more reliable. The test index is: ITA° value, which is the individual skin type angle. The larger the ITA° value, the brighter the skin. Therefore, the whitening effect of cosmetics can be evaluated by measuring the melanin content in the stratum corneum and skin color. △ITA° = Tn - T0; where Tn is the change in the test area over time, and T0 is the initial value of the test area.
[0027] Eighty adults with relatively dull facial skin were randomly divided into four groups of 20 participants each. Before using the sample, melanin and color difference data were collected and analyzed from their facial skin; these data served as baseline skin values. Participants used the sample twice daily, morning and evening, for four consecutive weeks. Data was collected at weeks 1 and 3. Changes in skin brightness levels before and after cosmetic use were assessed to determine the whitening effect of the cosmetic. The test results are shown in Table 2.
[0028] Table 2: Skin brightness test.
[0029]
[0030] As shown in Table 2, within the 3-week testing period, the skin brightness of Examples 1-3 was better than that of Comparative Example 1, indicating that the whitening and spot-fading repair essence containing tranexamic acid of the present invention has the effect of improving skin brightness.
[0031] Eighty adults with reddish facial skin were selected and randomly divided into four groups of 20 participants each. Their facial skin data were collected, analyzed, and tested before the samples were used.
[0032] Table 3: Skin redness test.
[0033]
[0034] As shown in Table 3, Examples 1-3 of the present invention have a better redness removal effect compared with Comparative Example 1.
[0035] The preferred embodiments of the present invention disclosed above are merely illustrative of the invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the invention to the specific implementations described. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of the invention, thereby enabling those skilled in the art to better understand and utilize the invention. The invention is limited only by the claims and their full scope and equivalents.
Claims
1. An essence for whitening and fading freckles containing tranexamic acid, characterized in that, It comprises the following weight components: 3-10 parts by weight of tranexamic acid, 1-4 parts by weight of alpha-arbutin, 0.01-1 parts by weight of carboxymethyl chitosan, 0.5-1.5 parts by weight of Saccharomyces bifida ferment lysate, 0.02-0.04 parts by weight of 1,2-hexanediol, 0.01-0.03 parts by weight of p-hydroxyacetophenone, 0.05-5 parts by weight of glycyrrhizin, 2-3 parts by weight of a humectant, 0.05-0.5 parts by weight of carbomer, 0.02-0.1 parts by weight of disodium EDTA, 0.05-0.5 parts by weight of arginine, C12-15 paraffin alcohol polyether-12, 0.02-0.2 PEG-40 hydrogenated castor oil, 1-2 parts by weight of modified chitosan, and 6-8 parts by weight of water. 2.The whitening and freckle-removing essence containing tranexamic acid according to claim 1, characterized in that, The humectant is: 0.05-5 parts by weight of betaine, 1-3 parts by weight of 1,2-hexanediol, 0.05-4 parts by weight of exopolysaccharide, and 0.05-4 parts by weight of bis-diethoxydiglycol cyclohexane 1,4-dicarboxylate. 3.The whitening and freckle-removing essence containing tranexamic acid according to claim 1, characterized in that, The preparation method of the modified chitosan is: (1) 10-12 parts by weight of chitosan and 8-16 parts by weight of ε-caprolactone are added to a stirrer, stirred uniformly, then 0.1-0.3 parts by weight of stannous octoate catalyst is added, nitrogen is introduced for protection, and the reaction is carried out at 120-140℃ for 6-10h. After the reaction is completed, the crude product is first dissolved in chloroform, then precipitated with anhydrous ether, and repeated dissolution and precipitation is carried out 3-4 times. The product is vacuum dried to obtain caprolactone-modified chitosan; (2) Deionized water is added to 7-12 parts by weight of chitosan for dissolution, heated in a water bath at 70-85℃, and 6-10 parts by weight of 2,3-epoxypropyltrimethylammonium chloride is added at constant pressure. The reaction is carried out for 4-6h, washed after the reaction, and vacuum dried to obtain quaternary ammonium chitosan; (3) Glycine-arginine-glycine-aspartic acid-serine pentapeptide and taurine are simultaneously dissolved in a 0.4-0.6mol / L sodium bicarbonate solution, then the mixture is placed in an ice water bath, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride is added, stirred at 3-5℃ for 15-25min, then taken out, dialyzed and dried to obtain an intermediate; (4) Quaternary ammonium chitosan and the intermediate are added to N,N-dimethylformamide solvent, stirred and dispersed, p-toluenesulfonic acid catalyst is added, the reaction is carried out at 70-80℃ for 5-7h, then vacuum distillation is carried out after the reaction is completed, filtered and dried to obtain modified chitosan. 4.The whitening and freckle-removing essence containing tranexamic acid according to claim 3, characterized in that, The mass ratio of glycine-arginine-glycine-aspartic acid-serine pentapeptide, taurine and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride in (3) is 1:2.2-2.6:1.4-2.
3. 5.The whitening and freckle-removing essence containing tranexamic acid according to claim 3, characterized in that, The mass ratio of quaternary ammonium chitosan, intermediate and p-toluenesulfonic acid catalyst in (4) is 1.2-1.4:1:0.02-0.
03.
6. A method of preparing the tranexamic acid-containing whitening and freckle-removing repair serum according to any one of claims 1 to 5, characterized by, The preparation method of the whitening and freckle-removing repair essence containing tranexamic acid comprises the following steps: A phase raw materials: purified water, carbomer, disodium EDTA, humectant; Phase B raw materials: 1,2-hexanediol, carboxymethyl chitosan; Phase C raw materials: arginine; Phase D raw materials: tranexamic acid, alpha-meloside, saccharomyces lycium ferment lysate, p-hydroxyacetophenone, glycyrrhizin; Phase E raw materials: C12-15 paraffin alcohol polyether-12, PEG-40 hydrogenated castor oil, modified chitosan; S1. Add phase A to the main tank in turn, soak and dissolve, then stir and heat to 80-85℃; S2. After uniformly mixing and dispersing phase B, add it to the main tank, stir and keep warm for 30 minutes until completely dissolved; S3. Pre-dissolve phase C at a temperature of 60-70℃, then add it to the main tank after complete dissolution, stir and cool to 40-45℃; S4. After completely dissolving phase D, add it to the main tank, stir until completely dissolved; S5. After uniformly mixing phase E, add it to the main tank, stir until uniform; S6. Stop stirring, take samples to test physical and chemical indexes and microorganisms, and discharge after the physical and chemical indexes are qualified, thus obtaining the whitening and freckle-removing repair essence containing tranexamic acid.