A stock solution dispensing apparatus and method

Abstract

The present application relates to the technical field of raw solution subpackaging or filling; the present application provides a raw solution subpackaging device and method, the device comprising: a rack; a subpackaging container, the rack is provided with a plurality of subpackaging containers from top to bottom; a liquid conveying mechanism and a subpackaging pipeline, the liquid conveying mechanism is connected with a plurality of subpackaging containers through the subpackaging pipeline; an exhaust assembly, the subpackaging pipeline is connected with the exhaust assembly, and the exhaust assembly is used for exhausting air in the subpackaging pipeline; the subpackaging pipeline comprises a subpackaging main pipeline, a plurality of subpackaging branch pipelines in communication with the subpackaging main pipeline, and a plurality of subpackaging branch pipelines are connected with a plurality of subpackaging containers respectively; the present application adopts pneumatic pushing and a peristaltic pump, so that the risk of raw solution pollution caused by silica gel tube particle shedding is eliminated. The subpackaging amount is calculated in real time through a pressure and fluid mechanics model, a weighing sensor is not needed, and the influence of environmental vibration, air flow and the like on weighing is avoided.

Description

Technical Field

[0001] This invention relates to the technical field of liquid dispensing or filling, and particularly to a liquid dispensing equipment and method. Background Technology

[0002] As market demand for vaccines, antibodies, and other drugs increases year by year, the production systems of biopharmaceutical companies are also gradually expanding. To meet the downstream pharmaceutical industry's demand for bulk solution storage, both manual filling and semi-automatic / automatic mechanical dispensing technologies have emerged.

[0003] However, the current mainstream liquid concentrate repackaging technology has the following shortcomings:

[0004] The shortcomings of traditional manual packaging:

[0005] Poor consistency, heavily reliant on operator skill level and proficiency, packaging volume varies from person to person, poor repeatability (RSD may be >3%);

[0006] The risk of contamination is high. Open or semi-open operations can easily introduce microorganisms, endotoxins and particulate matter, posing a huge challenge to aseptic assurance.

[0007] Inefficient and unable to meet the needs of large-scale clinical trials or commercial production.

[0008] The shortcomings of existing mechanical packaging:

[0009] The dispensing accuracy and stability are insufficient. Currently, mainstream products use peristaltic pumps as power sources and use weighing sensors to calculate the weight inside the bag by superimposing the weight. This method has high requirements for each step and is easily affected by external factors, which can affect the dispensing accuracy.

[0010] The equipment operates at a relatively low speed and efficiency. Currently, the mainstream products use individual bag dispensing and cannot dispense multiple bags simultaneously.

[0011] There is a risk of contamination. When the peristaltic pump is running, it squeezes the silicone tube, which may cause tiny particles in the silicone tube to fall off, posing a risk of contamination. Summary of the Invention

[0012] Based on this, the purpose of the present invention is to provide a raw liquid dispensing device and method;

[0013] The invention provides the following technical solution: a liquid dispensing device, comprising:

[0014] Material rack;

[0015] The liquid separation container is provided on the material rack from top to bottom;

[0016] An infusion mechanism and a dispensing pipeline, wherein the infusion mechanism is connected to a plurality of dispensing containers via the dispensing pipeline;

[0017] An exhaust assembly is provided, wherein the dispensing pipe is connected to the exhaust assembly, and the exhaust assembly is used to exhaust the air in the dispensing pipe.

[0018] The dispensing pipeline includes a main dispensing pipeline and multiple dispensing branches connected to the main dispensing pipeline, with each of the multiple dispensing branches connected to a multiple dispensing containers.

[0019] The main liquid distribution path includes a main pipeline and a first pressure sensor installed on the main pipeline; the first pressure sensor is used to detect the pressure value inside the main pipeline.

[0020] The infusion mechanism delivers the original solution sequentially through the main pipeline and the distribution branch to the distribution container; and calculates the amount dispensed into the distribution container in real time, closing the corresponding distribution branch when the amount dispensed reaches a set weight.

[0021] The real-time calculation of the dispensing volume entering the dispensing container The calculation is performed using the first calculation formula:

[0022]

[0023] Where M is the dispensing volume, Let D be the liquid density and D be the inner diameter of the pipe. This is the value detected by the first pressure sensor, where g is the acceleration due to gravity. The height difference between the first pressure sensor and the center point of each liquid distribution branch. Where is atmospheric pressure, f is the Darcy friction factor, L is the pipe length, and A is the pipe cross-sectional area. This refers to the dispensing time.

[0024] Furthermore, the liquid distribution branch includes:

[0025] The liquid distribution tube is connected at one end to the liquid distribution container and at the other end to the main pipeline.

[0026] A second electric valve is used to close or open the channel of the separator.

[0027] Furthermore, the infusion mechanism includes: an infusion component and a gas delivery component;

[0028] The infusion assembly includes: a stock solution tank and a piston; the stock solution tank is used to store the stock solution, and the stock solution tank is connected to the gas delivery assembly and the main pipeline; the piston is slidably connected inside the stock solution tank; gas is delivered into the stock solution tank through the gas delivery assembly, thereby pushing the piston to move, and the movement of the piston inputs the stock solution in the stock solution tank into the main pipeline.

[0029] Furthermore, the gas delivery assembly includes:

[0030] A gas transmission pipeline, one end of which is connected to the raw liquid tank and the other end of which is connected to an external gas supply device;

[0031] An electro-proportional valve and a second pressure sensor are provided on the gas transmission pipeline.

[0032] Furthermore, the exhaust assembly includes:

[0033] An exhaust bag, which is connected to the main pipe;

[0034] A detection unit is installed on the main pipeline for detecting the liquid level in the main pipeline and for closing or opening the channel between the main pipeline and the vent bag. The detection unit is located above the uppermost liquid distribution branch.

[0035] Furthermore, the main liquid distribution path also includes a first valve and a first liquid level sensor installed on the main pipeline, wherein the first valve and the first liquid level sensor are located away from the venting assembly.

[0036] A method for dispensing raw liquid, applied in the aforementioned raw liquid dispensing equipment, includes the following steps:

[0037] The air in the dispensing pipeline is discharged through the exhaust assembly, so that the original liquid fills the dispensing pipeline.

[0038] Set the liquid weight and number of bags, open the corresponding liquid dispensing branch, and input the original liquid into each liquid dispensing container through the infusion mechanism;

[0039] The amount of liquid entering the dispensing container is calculated in real time, and the corresponding dispensing branch is closed when the amount of liquid entering the container reaches the set weight.

[0040] Furthermore, after the step of calculating the dispensing volume into the dispensing container in real time and closing the corresponding dispensing branch when the dispensing volume reaches the set weight, the method further includes the following steps:

[0041] Once the liquid dispensing containers at the same height reach the set weight, close all liquid dispensing branches at the same height.

[0042] Recalculate the dispensing volume into the remaining dispensing containers until all dispensing containers are filled.

[0043] Furthermore, the recalculation of the dispensing volume entering the remaining dispensing container... The calculation is performed using the second formula:

[0044]

[0045]

[0046] in, This refers to the dispensing volume of the remaining liquid in the dispensing container. This refers to the total dispensing volume of the dispensing container. The value detected by the first pressure sensor when all dispensing branches at the same height are closed after the dispensing containers at the same height reach the set weight. This refers to the dispensing time recorded after all dispensing branches at the same height are closed once the set weight is reached in the dispensing containers at the same height.

[0047] The beneficial effects of this invention are: avoiding contamination: it uses pneumatic propulsion, eliminating the need for a peristaltic pump, thus eliminating the risk of silicone tube particles falling off and contaminating the original solution.

[0048] High-precision dispensing: The dispensing volume is calculated in real time through pressure and fluid dynamics models, eliminating the need for weighing sensors and avoiding the influence of environmental vibrations and airflow on weighing.

[0049] High efficiency and parallel processing: Supports simultaneous dispensing of multiple bags, significantly improving dispensing efficiency.

[0050] High degree of automation: The entire process is automatically controlled, reducing human intervention and improving consistency and aseptic assurance levels. Attached Figure Description

[0051] Figure 1 This is a three-dimensional structural diagram of the present invention.

[0052] Figure 2 This is a plan view of the present invention.

[0053] Figure 3 This is a three-dimensional structural diagram of the infusion assembly, main pipeline, dispensing pipe, and dispensing bag of the present invention.

[0054] Figure 4 This is an exploded view of the infusion assembly of the present invention.

[0055] Figure 5 This is a flowchart of the method in Embodiment 2 of the present invention.

[0056] The labels in the attached diagram are as follows: 1-Packaging rack, 11-Base plate, 12-Upright plate, 13-Frame, 14-Packing plate, 15-First caster wheel, 2-Infusion assembly, 21-Solid tank, 22-Second caster wheel, 23-Air inlet, 24-Guide rail, 25-Piston, 26-Sealing ring, 27-Cover plate, 28-Solid inlet / outlet, 3-Main distribution pipeline, 31-Main pipeline, 32-First electric clamp valve, 33-First pressure sensor, 34-First level sensor, 4-Branch distribution, 41-Distribution pipe, 42-Second electric clamp valve, 5-Distribution bag, 6-Exhaust assembly, 61-Second level sensor, 62-Third electric clamp valve, 63-Exhaust bag, 7-Gas delivery assembly, 71-Gas delivery pipeline, 72-Electrical proportional valve, 73-Second pressure sensor, 74-Pure gas inlet. Detailed Implementation

[0057] To facilitate understanding of the present invention, a more complete description will be given below with reference to the accompanying drawings. Several embodiments of the invention are illustrated in the drawings. However, the invention can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

[0058] It should be noted that when a component is said to be "fixed to" another component, it can be directly on the other component or there may be an intervening component. When a component is said to be "connected to" another component, it can be directly connected to the other component or there may be an intervening component. The terms "vertical," "horizontal," "left," "right," and similar expressions used in this document are for illustrative purposes only.

[0059] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0060] Example 1:

[0061] like Figures 1 to 4 As shown, this embodiment provides a raw material dispensing device, mainly including: a material rack 1, a liquid delivery assembly 2, a dispensing pipeline, a dispensing bag 5, an exhaust assembly 6, and a gas delivery assembly 7. The following provides a detailed description of each part:

[0062] Material rack 1:

[0063] The material rack 1 adopts a stainless steel frame 13 structure, with multiple storage platforms from top to bottom. Each layer can hold two dispensing bags 5 as dispensing containers.

[0064] Specifically, such as Figure 2 As shown, the material rack 1 includes: upright plates 12, frame 13, placement plates 14, and casters; the base plate 11 is a square plate, and each of its four bottom corners is equipped with a first caster 15 to move the entire material rack 1; upright plates 12 are fixedly connected to the top two sides of the base plate 11, and five placement plates 14 are horizontally extended from the two upright plates 12 towards the middle of the base plate 11. The placement plates 14 are used to place the dispensing bags 5. The five placement plates 14 on each upright plate 12 are arranged in pairs at the same level from top to bottom. The horizontal shelf 14 is one layer. In this embodiment, there are five layers of shelf platforms for placing the dispensing bags 5. Each shelf platform can hold two dispensing bags 5. The number of layers of shelf platforms can be adjusted according to the actual situation, which will not be elaborated here. The left side of the frame 13 is fixedly connected to the ends of the five shelf 14 on one of the upright plates 12, and the right side is fixedly connected to the ends of the five shelf 14 on another upright plate 12. The frame 13 is located in the middle of the entire shelf rack 1, and the top of the shelf rack 1 is used to place the exhaust bag 63.

[0065] Separating containers; the material rack 1 has multiple separating containers arranged from top to bottom;

[0066] Specifically, the dispensing container is a dispensing bag 5, which is a sterile pharmaceutical-grade plastic bag placed on the shelf 14 to receive the dispensed original solution.

[0067] The infusion mechanism and dispensing pipeline are connected to multiple dispensing containers via the dispensing pipeline.

[0068] The infusion mechanism includes an infusion component 2 and a gas delivery component 7; the gas delivery component 7 is used to deliver constant-pressure gas into the infusion component 2.

[0069] The infusion assembly 2 includes: a stock solution tank 21 and a piston 25; the stock solution tank 21 is used to store the stock solution and is connected to the gas delivery assembly 7 and the main pipeline 31; the piston 25 is slidably connected inside the stock solution tank 21; gas is delivered into the stock solution tank 21 through the gas delivery assembly 7, thereby pushing the piston 25 to move, and the movement of the piston 25 inputs the stock solution in the stock solution tank 21 into the main pipeline 31.

[0070] Specifically, such as Figure 4As shown, the bottom of the raw liquid tank 21 is triangularly equipped with three second universal wheels 22 to move the raw liquid tank 21. The interior of the raw liquid tank 21 is hollow to store the raw liquid and install the piston 25. The top wall of the raw liquid tank 21 is composed of a detachable cover plate 27, which is sealed to the top of the raw liquid tank 21. The cover plate 27 is provided with an air inlet 23 that communicates with the interior of the raw liquid tank 21 and is used to connect with the gas delivery assembly 7. Guide rails 24 are fixedly connected to both sides of the inner wall of the raw liquid tank 21, and the piston 25 is slidably connected to the inner wall of the raw liquid tank 21 through the guide rails 24. Two sealing rings 26 are fitted on the outer wall of the piston 25, and the sealing rings 26 are tightly fitted with the inner wall of the raw liquid tank 21 to achieve a sealed contact. The bottom of the raw liquid tank 21 is provided with a raw liquid inlet and outlet 28 that communicates with the interior of the raw liquid tank. The raw liquid inlet and outlet 28 is used to introduce or export the raw liquid into the raw liquid tank 21, and the raw liquid inlet and outlet 28 is also used to connect with the dispensing pipeline.

[0071] like Figure 2 The gas delivery assembly 7 shown includes: a gas delivery pipeline 71, an electro-proportional valve 72, and a second pressure sensor 73;

[0072] One end of the gas pipeline 71 is connected to the raw liquid tank 21, and the other end is connected to the external gas supply device;

[0073] Specifically, one end of the gas pipeline 71 is connected to the air inlet 23, and the other end is connected to the external gas supply device through the external pure gas inlet 74;

[0074] An electric proportional valve 72 and a second pressure sensor 73 are installed on the gas pipeline 71.

[0075] Specifically, the electro-proportional valve 72 is installed on the gas pipeline 71 to precisely control the gas pressure entering the raw material tank 21. The second pressure sensor 73 is installed on the gas pipeline 71 and located after the electro-proportional valve 72 to monitor the gas pressure in real time.

[0076] like Figure 2 and Figure 3 As shown, the dispensing pipeline includes a main dispensing line and multiple dispensing branches 4 connected to the main dispensing line. The number of dispensing branches 4 corresponds to the number of dispensing containers. The multiple dispensing branches 4 are connected to multiple dispensing containers respectively.

[0077] The main liquid separation circuit includes: main pipeline 31 and first pressure sensor 33;

[0078] A portion of the main pipe 31 is fixedly connected to the frame 13, and the portion fixedly connected to the frame 13 is vertical. One end of the main pipe 31 is connected to the raw liquid inlet / outlet 28 of the raw liquid tank 21, and the other end is connected to the exhaust assembly 6. A first pressure sensor 33 is installed on the main pipe 31 to detect the liquid pressure inside the main pipe 31. The first pressure sensor 33 is lower than the lowest storage platform.

[0079] Furthermore, in order to discharge and recycle the liquid in the main pipeline 31, the main liquid distribution pipeline also includes a first liquid level sensor 34 and a first valve;

[0080] The first liquid level sensor 34 and the first electric pipe clamp valve 32 are both located at the lower part of the main pipeline 31 and are fixedly connected to the frame 13. The first liquid level sensor 34 is used to detect whether there is liquid in the pipeline, and the first electric pipe clamp valve 32 is used to control the opening and closing of the main pipeline 31.

[0081] It is understandable that after all the dispensing bags 5 have finished dispensing, the original liquid tank 21 and the main pipeline 31 are disconnected, all valves are closed, and only the first electric pipe clamp valve 32 and the third electric pipe clamp valve 62 are opened. At this time, the residual liquid in the pipeline will flow downward due to gravity. The liquid can be collected by a container to achieve the function of recycling. When the indicator light of the first liquid level sensor 34 goes out, it means that the residual liquid in the pipeline has been collected.

[0082] like Figure 2 As shown, the liquid distribution branch 4 includes a liquid distribution pipe 41 and a second electric valve, which is a second electric clamping sub-valve 42.

[0083] One end of the dispensing pipe 41 is connected to the main pipe 31, and the other end is connected to the corresponding dispensing bag 5. Each dispensing pipe 41 is equipped with a second electric pipe clamp valve 42 to control the opening and closing of the branch, and the second electric pipe clamp valve 42 is fixedly connected to the frame 13.

[0084] In addition, the maximum number of distribution bags (5) is limited by the diameter of the main pipeline and the diameter of the corresponding distribution pipe (41). The maximum number of bags * the cross-sectional area of ​​the corresponding distribution pipe (41) should be less than or equal to the cross-sectional area of ​​the main pipeline (31) to prevent the branch pipeline from being empty.

[0085] like Figure 2 As shown, the exhaust assembly 6 includes: an exhaust bag 63, a second liquid level sensor 61, and a third electric valve, wherein the third electric valve is a third electric clamping sub-valve 62.

[0086] The exhaust bag 63 is connected to the end of the main pipe 31 and is used to collect liquid and residual gas in the main pipe 31 during the exhaust stage.

[0087] The second liquid level sensor 61 and the third electric pipe clamp valve 62 are both installed on the main pipe 31 and located before the inlet of the exhaust bag 63, higher than the uppermost storage platform. The second liquid level sensor 61 and the third electric pipe clamp valve 62 are both fixed on the frame 13. The second liquid level sensor 61 is used to detect the liquid level in the pipe, and the third electric pipe clamp valve 62 is used to control the opening and closing of the exhaust channel.

[0088] To further explain, the electric valve in this embodiment can be replaced with other electric valves besides the electric clamp valve. Electric valves are common existing technology and will not be described in detail here.

[0089] Work process:

[0090] The stock solution tank 21 is filled with stock solution, and the piston 25 is in the highest position.

[0091] Open the passage where the third electric pipe clamp valve 62 and the second liquid level sensor 61 are located, and at the same time open the first electric pipe clamp valve 32.

[0092] When the gas delivery assembly 7 is started, the pure gas enters the raw liquid tank 21 after being regulated by the electric proportional valve 72, pushing the piston 25 to move down, and the raw liquid enters the main pipeline 31.

[0093] When the second liquid level sensor 61 detects liquid, it indicates that the air in the pipeline has been purged. The third electric clamp valve 62 is then closed, and the purging process is complete.

[0094] Set the weight of each bag (e.g., 5kg) and the number of bags (e.g., 4 bags) through the control interface.

[0095] The system automatically calculates and determines whether the condition "maximum number of bags × corresponding distribution pipe cross-sectional area 41 ≤ main pipe cross-sectional area 31" is met to prevent empty liquid phenomenon.

[0096] Open the second electric clamp valve 42 of the corresponding liquid distribution branch 4 (if all 4 are opened simultaneously).

[0097] The gas delivery component 7 maintains a constant gas pressure, pushing the original liquid into each dispensing bag 5.

[0098] The system uses the detection value of the first pressure sensor 33 Elevation differences between branch roads Liquid density The formula for calculating the dispensing amount in each bag in real time is as follows: (Parameters are listed below.)

[0099]

[0100] Where M is the dispensing volume, Let D be the liquid density and D be the inner diameter of the pipe. The value is detected by the first pressure sensor 33, where g is the acceleration due to gravity. The height difference between the first pressure sensor 33 and the center point of each liquid distribution branch 4. Where is atmospheric pressure, f is the Darcy friction factor, L is the pipe length, and A is the pipe cross-sectional area. This refers to the dispensing time.

[0101] When the liquid distribution bag 5 of a certain layer (such as the first layer) reaches the set weight, the system closes all the second electric clamp valves 42 of that layer.

[0102] The system records the new value of the first pressure sensor 33 at this time. And restart the timer for T2.

[0103] Based on the updated pressure values Recalculate the dispensing volume of the remaining dispensing bag 5. Continue until all bags are fully packaged. The calculation formula is as follows:

[0104]

[0105]

[0106] in, This refers to the dispensing volume of the remaining liquid in the dispensing container. This refers to the total dispensing volume of the dispensing container. The value detected by the first pressure sensor when all dispensing branches at the same height are closed after the dispensing containers at the same height reach the set weight. This refers to the dispensing time recorded after all dispensing branches at the same height are closed once the set weight is reached in the dispensing containers at the same height.

[0107] Therefore, the total mass of the remaining separatory container When the value equals the set weight, the second electric clamp valve 42 of that layer is closed, and the set liquid separation process ends.

[0108] Beneficial effects of this embodiment

[0109] Avoid contamination: Pneumatic drive eliminates the need for a peristaltic pump, thus eliminating the risk of silicone tube particles falling off and contaminating the original solution.

[0110] High-precision dispensing: The dispensing volume is calculated in real time through pressure and fluid dynamics models, eliminating the need for weighing sensors and avoiding the influence of environmental vibrations and airflow on weighing.

[0111] High efficiency and parallel processing: Supports simultaneous dispensing of multiple bags, significantly improving dispensing efficiency.

[0112] High degree of automation: The entire process is automatically controlled, reducing human intervention and improving consistency and aseptic assurance levels.

[0113] Example 2:

[0114] This embodiment provides a method for dispensing the original solution, which is applied in Embodiment 1, such as... Figure 5 As shown, it includes the following steps:

[0115] The air in the dispensing pipeline is discharged through the exhaust assembly 6, so that the original liquid fills the dispensing pipeline.

[0116] Set the liquid weight and number of bags, open the corresponding liquid dispensing branch 4, and input the original liquid into each liquid dispensing container through the infusion mechanism;

[0117] The amount of liquid entering the dispensing container is calculated in real time, and the corresponding dispensing branch 4 is closed when the amount of liquid entering the dispensing container reaches the set weight.

[0118] When the liquid distribution containers at the same height reach the set weight, close all liquid distribution branches at the same height 4;

[0119] Recalculate the dispensing volume into the remaining dispensing containers until all dispensing containers are filled.

[0120] The real-time calculation of the dispensing volume entering the dispensing container is performed using a first calculation formula:

[0121]

[0122] Where M is the dispensing volume, Let D be the liquid density and D be the inner diameter of the pipe. The value is detected by the first pressure sensor 33, where g is the acceleration due to gravity. The height difference between the first pressure sensor 33 and the center point of each liquid distribution branch 4. Where is atmospheric pressure, f is the Darcy friction factor, L is the pipe length, and A is the pipe cross-sectional area. This refers to the dispensing time.

[0123] The recalculation of the dispensing volume entering the remaining dispensing container is performed using the second calculation formula:

[0124]

[0125]

[0126] in, This refers to the dispensing volume of the remaining liquid in the dispensing container. This refers to the total dispensing volume of the dispensing container. The value detected by the first pressure sensor when all dispensing branches at the same height are closed after the dispensing containers at the same height reach the set weight. This refers to the dispensing time recorded after all dispensing branches at the same height are closed once the set weight is reached in the dispensing containers at the same height.

[0127] The derivation process of the first calculation formula is as follows:

[0128] After the venting is completed, the weight of each bag to be dispensed is set through the control interface (e.g., 5kg) and the number of bags to be dispensed (e.g., 4 bags); the second electric tube clamp valve 42 corresponding to the liquid dispensing branch 4 is opened (e.g., 4 valves are opened simultaneously, which are the second electric tube clamp valves 42 corresponding to the liquid dispensing bags 5 on the bottom two storage platforms).

[0129] The gas delivery assembly 7 maintains a constant gas pressure, pushing piston 25 downwards. The pressure of the pure gas in the upper part of piston 25, which serves as the power source, remains constant at a set value. The liquid pressure in all pipes is also constant. At this time, the value of the first pressure sensor 33 is... Due to the potential energy difference caused by height, the pressure in the liquid distribution branch 4 is not the same. The liquid distribution branches 4 at the bottom platform (stations 1 and 2) are at the same height, so the liquid pressure inside the pipes is the same. Similarly, the liquid distribution branches 4 at the upper platform (stations 3 and 4) are at the same height, so the pressure inside the pipes is the same. At this time, the mass of liquid in station 1... The derived calculation formula is as follows:

[0130]

[0131]

[0132] in, Let g be the density of the liquid and g be the acceleration due to gravity. The height difference between the center point of the first pressure sensor 33 and the center point of the first liquid distribution branch 4;

[0133] According to the Darcy-Weisbach formula:

[0134]

[0135] in, The pressure difference between imports and exports (Pa); For import pressure (Pa), Where is the outlet pressure (Pa), f is the Darcy friction factor, L = pipe length (m), L can be obtained by measuring the pipe length from the main pipe to the separator 5; D is the pipe inner diameter (m). The density of the liquid;

[0136] Simplifying, we get:

[0137]

[0138]

[0139] in, At atmospheric pressure, therefore Known;

[0140]

[0141] Therefore, after time T1, the volume of liquid flowing through is V = Q. And Q = V * A; where A = cross-sectional area of ​​the pipe;

[0142]

[0143] Since station 2 and station 1 are at the same height, the mass of the liquid in bag 1 is... Compared with the liquid mass in bag No. 2 same;

[0144] Since workstations 3 and 4 are at the same height, the liquid mass in bag 3 is... Compared with the liquid mass in bag No. 4 same;

[0145]

[0146] in, The height difference between the center point of the first pressure sensor 33 and the center point of the second liquid distribution branch 4;

[0147] Due to the height potential energy difference between the first and second storage platforms, the liquid pressure on the first platform is greater than that on the second platform. The dispensing bag 5 on the first platform will reach the set weight first. At this point, the second electric clamp valve 42 on the first platform closes. Because both outlets are closed, the constant conditions change, and the value of the first pressure sensor 33 changes. The value of the first pressure sensor 33 at this time is recorded. The timing begins after the second electric clamp valve 42 on the first layer is closed; the recorded time at this point is... Based on the above derivation, it can be calculated that when the first layer second electric clamp valve 42 is closed, The mass of liquid injected into the dispensing bag 5 at station 3 within the specified time period for:

[0148]

[0149]

[0150]

[0151] Therefore, when the total mass of the liquid in the dispensing bag 5 at station 3 is... When the value equals the set weight, the second electric clamp valve 42 on the second-layer placement platform closes, and the set liquid separation process ends.

[0152] If you want to divide the product into more bags, you can also calculate the weight using the above derivation. You can divide the product into more bags at workstations 2, 4, 6, etc. As long as the maximum number of bags * the cross-sectional area of ​​the dispensing pipe 41 ≤ the cross-sectional area of ​​the main pipeline, you can calculate the weight of the dispensing product using the above formula.

[0153] In the description of this specification, references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0154] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these modifications and improvements all fall within the scope of protection of the present invention. Therefore, the scope of protection of this patent should be determined by the appended claims.

Claims

1. A raw material dispensing device, characterized in that, include: Material rack; The liquid separation container is provided on the material rack from top to bottom; An infusion mechanism and a dispensing pipeline, wherein the infusion mechanism is connected to a plurality of dispensing containers via the dispensing pipeline; An exhaust assembly is provided, wherein the dispensing pipe is connected to the exhaust assembly, and the exhaust assembly is used to exhaust the air in the dispensing pipe. The dispensing pipeline includes a main dispensing pipeline and multiple dispensing branches connected to the main dispensing pipeline, with each of the multiple dispensing branches connected to a multiple dispensing containers. The main liquid distribution path includes a main pipeline and a first pressure sensor installed on the main pipeline; the first pressure sensor is used to detect the pressure value inside the main pipeline. The infusion mechanism delivers the original solution sequentially through the main pipeline and the distribution branch to the distribution container; and calculates the amount dispensed into the distribution container in real time, closing the corresponding distribution branch when the amount dispensed reaches a set weight. The real-time calculation of the dispensing volume entering the dispensing container The calculation is performed using the first calculation formula: Where M is the dispensing volume, Let D be the liquid density and D be the inner diameter of the pipe. This is the value detected by the first pressure sensor, where g is the acceleration due to gravity. The height difference between the first pressure sensor and the center point of each liquid distribution branch. Where is atmospheric pressure, f is the Darcy friction factor, L is the pipe length, and A is the pipe cross-sectional area. This refers to the dispensing time.

2. The raw material dispensing equipment according to claim 1, characterized in that, The liquid separation branch includes: The liquid distribution tube is connected at one end to the liquid distribution container and at the other end to the main pipeline. A second electric valve is used to close or open the channel of the separator.

3. The raw material dispensing equipment according to claim 1, characterized in that, The infusion mechanism includes: an infusion component and a gas delivery component; The infusion assembly includes: a stock solution tank and a piston; the stock solution tank is used to store the stock solution, and the stock solution tank is connected to the gas delivery assembly and the main pipeline; the piston is slidably connected inside the stock solution tank; gas is delivered into the stock solution tank through the gas delivery assembly, thereby pushing the piston to move, and the movement of the piston inputs the stock solution in the stock solution tank into the main pipeline.

4. The raw material dispensing equipment according to claim 3, characterized in that, The gas delivery assembly includes: A gas transmission pipeline, one end of which is connected to the raw liquid tank and the other end of which is connected to an external gas supply device; An electro-proportional valve and a second pressure sensor are provided on the gas transmission pipeline.

5. The raw material dispensing equipment according to claim 1, characterized in that, The exhaust assembly includes: An exhaust bag, which is connected to the main pipe; A detection unit is installed on the main pipeline for detecting the liquid level in the main pipeline and for closing or opening the channel between the main pipeline and the vent bag. The detection unit is located above the uppermost liquid distribution branch.

6. The raw material dispensing equipment according to claim 1, characterized in that, The main liquid distribution path further includes a first valve and a first liquid level sensor installed on the main pipeline, wherein the first valve and the first liquid level sensor are located away from the venting assembly.

7. A method for dispensing raw liquid, applied in the raw liquid dispensing equipment according to any one of claims 1-6, characterized in that, Includes the following steps: The air in the dispensing pipeline is discharged through the exhaust assembly, so that the original liquid fills the dispensing pipeline. Set the liquid weight and number of bags, open the corresponding liquid dispensing branch, and input the original liquid into each liquid dispensing container through the infusion mechanism; The amount of liquid entering the dispensing container is calculated in real time, and the corresponding dispensing branch is closed when the amount of liquid entering the container reaches the set weight.

8. The method for dispensing the stock solution according to claim 7, characterized in that, After the step of calculating the dispensing volume into the dispensing container in real time and closing the corresponding dispensing branch when the dispensing volume reaches the set weight, the method further includes the following steps: Once the liquid dispensing containers at the same height reach the set weight, close all liquid dispensing branches at the same height. Recalculate the dispensing volume into the remaining dispensing containers until all dispensing containers are filled.

9. The method for dispensing the stock solution according to claim 8, characterized in that, The recalculation of the dispensing volume into the remaining dispensing container The calculation is performed using the second formula: in, This refers to the dispensing volume of the remaining liquid in the dispensing container. This refers to the total dispensing volume of the dispensing container. The value detected by the first pressure sensor when all dispensing branches at the same height are closed after the dispensing containers at the same height reach the set weight. This refers to the dispensing time recorded after all dispensing branches at the same height are closed once the set weight is reached in the dispensing containers at the same height.

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