Reagent strip interval quantification technology
By marking the same indicator with different concentrations on the reagent strip and using the colorimetric results to determine the sample concentration range, the problem of accurate quantification of sample concentration in colloidal gold technology is solved, achieving accurate quantification and reducing human error.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-20
- Publication Date
- 2026-03-20
AI Technical Summary
Existing colloidal gold technology has difficulty in achieving accurate quantification of sample concentration, especially due to problems such as large human interpretation errors and equipment dependence.
The same indicator is continuously labeled with different concentrations on the reagent strip, and the concentration range of the sample is determined by the color development result, so as to achieve accurate quantification.
It enables precise quantification of sample concentration on the same test strip, reduces human interpretation errors, and lowers dependence on equipment.
Smart Images
Figure HDA0005258682090000011 
Figure HDA0005258682090000012
Abstract
Description
TECHNICAL FIELD
[0001] In one reagent strip, different concentrations of the same index are marked, and after the sample and the different concentrations of the mark react, if the preset value corresponding to the different marks is exceeded, color development is carried out, and through the reaction result, it can be directly judged that the sample concentration is in which interval, and interval quantification is realized. The technology can also realize interval quantification technology of two or more indexes on the same reagent strip. BACKGROUND
[0002] At present, the colloidal gold technology has three kinds of technology of qualitative, semi-quantitative and quantitative 1. Qualitative is to judge the sample to be positive by color development after the sample concentration exceeds the predetermined cutoff value. 2. Semi-quantitative technology is to color develop after the sample concentration exceeds the cutoff value, and then manually compare with a color development card, which is usually divided into 10 equal parts, and a manual reading result is obtained according to the manual comparison result. The result has a large manual factor. 3. Full quantitative technology needs to combine a machine to read the colloidal gold reagent strip. SUMMARY
[0003] Accurate interval quantification is realized. By marking different concentrations of the same index on the reagent strip, the concentration of the sample can be accurately defined according to the color development result. For example, if the cutoff value is 50 ug / ml, the color development is 100 ug / ml, and the sample concentration is in the interval of 50-100 ug / ml.
[0004] The following is an example of one index on one reagent strip: Taking fecal hemoglobin as an example, the fecal hemoglobin index is marked with three concentrations on the same reagent strip (two, three or more times of marking can also be performed), and the concentrations are 50 ug / g, 100 ug / g and 200 ug / g (the concentrations can also be defined as different concentrations). According to the color development interval, it can be judged that the sample is in which interval, such as Figure 1 It shows the interval of 100-200 ug / g. Figure 2 It shows the interval of 50-100 ug / g. BRIEF DESCRIPTION OF DRAWINGS Figure 1 It is the result of marking the fecal hemoglobin index with three concentrations on the same reagent strip according to the present application, and shows the interval of 100-200 ug / g. Figure 2 It is the result of marking the fecal hemoglobin index with three concentrations on the same reagent strip according to the present application, and shows the interval of 50-100 ug / g.
Claims
1. On a single test strip, different concentrations of the same indicator are labeled. After the sample reacts with the labels of different concentrations, if the concentration exceeds the preset value corresponding to each label, color development is performed. The reaction results allow for a direct assessment of the sample concentration range.
2. Different indicators can be mixed and labeled with different concentrations on a single test strip. After the sample and different concentrations of different samples react, if the value exceeds the corresponding predicted value of the different indicators, color development will occur. Through the reaction results, it is possible to intuitively determine which range the different indicators of the sample are in.