Salvianolic acid extraction and separation device

Abstract

The invention belongs to the technical field of pharmaceutical equipment, and aims to provide a salvianolic acid extraction and separation device which solves the problem that an existing salvianolic acid extraction and separation device is poor in production continuity. The salvianolic acid extraction and separation device comprises a shell, a liquid inlet and a liquid outlet are formed in the side wall of the shell, a feeding port and a discharging module are arranged at the top of the shell, and an arc-shaped filter plate is arranged in an inner cavity of the shell; the filter plate can rotate in a reciprocating mode around the axis in the shell, an arc-shaped opening in the filter plate faces the feeding port, the bottom of the discharging module extends into a columnar cavity of the filter plate, the top of the discharging module extends out of the shell, a plurality of pushing modules are arranged in the portion, between the feeding port and the discharging module, of the cavity of the filter plate, and the pushing modules are connected with the top wall of the shell. And the material pushing module can change the axial moving speed of the material on the filter plate.

Description

Technical Field

[0001] This invention belongs to the field of pharmaceutical equipment technology, and in particular relates to a device for extracting and separating tanshinone polyphenols. Background Technology

[0002] Tanshinone polyphenols are active ingredients extracted from tanshinone and have significant value in the clinical treatment of cardiovascular and cerebrovascular diseases. Current technologies for extracting tanshinone polyphenols often employ multi-functional extraction tanks to perform batch or tank group countercurrent extraction from crushed tanshinone. While this is more efficient than the single-stage extraction method used in laboratories, it is essentially still a batch process involving intermittent feeding and unloading. Material transfer and temporary storage operations are required between each step, resulting in poor production continuity and a long production cycle. Furthermore, tanshinone polyphenols are sensitive to light and heat and are easily oxidized, posing a risk of deterioration during material transfer. Therefore, there is an urgent need to develop an extraction and separation device that can achieve continuous feeding and slag discharge, thereby significantly improving the extraction efficiency, product stability, and production economy of tanshinone polyphenols. Summary of the Invention

[0003] The purpose of this invention is to provide a tanshinone polyphenol extraction and separation device in order to solve the problem of poor production continuity in existing tanshinone polyphenol extraction and separation devices.

[0004] The technical solution includes a housing, with an inlet and an outlet on the side wall of the housing, a feed inlet and a discharge module on the top of the housing, and an arc-shaped filter plate inside the housing. The filter plate can reciprocate around an axis inside the housing, with the arc-shaped opening on the filter plate facing the feed inlet. The bottom of the discharge module extends into the columnar cavity of the filter plate, and the top of the discharge module extends out of the housing. Multiple pusher modules are provided in the filter plate cavity between the feed inlet and the discharge module. The pusher modules are connected to the top wall of the housing and can change the axial movement speed of the material on the filter plate.

[0005] In the above or some embodiments, the shell is square in shape, and a U-shaped partition is provided inside the shell. The partition is welded and fixed to the shell, and a gap is left between the shell and the partition. The liquid inlet and liquid outlet are both connected to the inner cavity of the partition. The outer wall of the shell is provided with a water inlet and a water outlet. The partition isolates the filter plate from the water inlet. In use, organic solvent is introduced into the cavity inside the partition through the liquid inlet and liquid outlet, and heat transfer medium is introduced into the cavity between the partition and the shell through the water inlet and water outlet, so that the target substance is extracted under a set temperature environment, thereby improving the extraction efficiency.

[0006] In the above or some embodiments, the top of the housing is provided with an opening, and a cover plate is provided above the opening. The cover plate is fixed to the housing by screws. The feed inlet is located on the cover plate, and a hopper is provided above the feed inlet. The discharge module is fixed to the cover plate. The cover plate is made of a transparent material, such as acrylic. When in use, the transparent cover plate makes it easy to observe the reaction state inside the housing. The cover plate can be removed by screws for easy cleaning or maintenance.

[0007] In the above or some embodiments, the central angle of the filter plate is greater than 180 degrees. Vertical plates are fixed on both sides of the filter plate, and short shafts are fixed at the outer ends of the vertical plates. The two ends of the short shafts are connected to the side walls of the housing through bearings. A flat plate is welded below the short shaft on one side. An oblong hole is opened on the flat plate along the vertical direction. A drive motor is provided on the outside of the housing. A flywheel is fixed on the output shaft of the drive motor. A roller is fixed on the flywheel. The axis of the roller is parallel to and not collinear with the axis of the output shaft of the drive motor. The roller is always located in the oblong hole. When the drive motor drives the flywheel to rotate, the flywheel drives the filter plate to rotate back and forth through the roller, the oblong hole and the flat plate.

[0008] In the above or some embodiments, the inner wall of the filter plate is fixed with multiple baffles. The length direction of the baffles is parallel to the axis of the filter plate, the cross-sectional shape of the baffles is a right trapezoid, and the right-angled sidewalls of all the baffles face one direction. When the filter plate rotates in the direction of the inclined surface of the baffle, the baffle can push the material radially towards the axis. When the filter plate rotates in the direction of the right-angled sidewall of the baffle, the baffle can push the material circumferentially. Thus, in the process of reciprocating rotation, the material moves continuously in one direction, achieving a stirring effect.

[0009] In the above or some embodiments, the feeding module includes a baffle located inside the filter plate cavity and perpendicular to the filter plate axis. The horizontal cross-sectional shape of the filter plate is arc-shaped. A round rod is fixed to the top of the filter plate. The top of the round rod extends out of the housing and is welded with a turntable. A round tube is fixed to the top of the housing. The round tube is coaxial with the round rod and has a threaded hole with a bolt inside. Loosening the bolt allows the tilt angle of the baffle to be adjusted by the turntable, while tightening the bolt fixes the baffle to the housing.

[0010] In the above or some embodiments, the discharge module includes a filter cylinder located inside the housing with its axis vertical. The bottom of the filter cylinder extends into the inner cavity of the filter plate and has multiple clearance grooves. A cylinder is fixed to the top of the filter cylinder and is fixed to the top wall of the housing by screws. The top of the cylinder extends above the housing. A cylindrical tank is fixed to the top of the cylinder. The diameter of the cylindrical tank is larger than that of the cylinder, and the inner cavities of the cylindrical tank, the cylinder, and the filter cylinder are connected. An auger is coaxially installed inside the filter cylinder. The upper end of the auger extends into the inner cavity of the cylindrical tank. The shaft of the auger passes through the top of the cylindrical tank and is connected to a servo motor. The servo motor is fixed to the top wall of the cylindrical tank, and a discharge port is provided on the side wall of the cylindrical tank. The servo motor lifts the material entering the filter cylinder from the clearance grooves into the cylindrical tank through the auger and then discharges it from the discharge port. During the process of the auger lifting the material, the material is squeezed, and the organic solvent is squeezed out from the filter holes on the filter cylinder.

[0011] This technical solution has the following technical effects: 1. This device achieves continuous production of "feeding-extraction-separation-slag discharge" by continuously feeding material through the inlet, reciprocating rotation of the filter plate combined with multi-directional stirring of the baffle, adjusting the material movement speed of the pushing module, and continuous slag discharge by the auger of the discharge module. It completely eliminates the batch feeding, slag unloading and material transfer mode of existing equipment, greatly shortens the production cycle and realizes continuous production.

[0012] 2. This device not only completes extraction and separation within a closed shell, reducing the contact between tanshinone polyphenols and the external environment, but also significantly reduces the risk of deterioration of tanshinone polyphenols due to light and heat exposure and transfer processes, thus improving product stability; furthermore, the design of the shell and partitions allows for the circulation of both the heat transfer medium and organic solvents, facilitating precise temperature control of the extraction environment, avoiding high temperatures from damaging the activity of tanshinone polyphenols while providing suitable conditions for the extraction reaction.

[0013] 3. The reciprocating rotation of the filter plate combined with the right-angled trapezoidal cross-section structure of the baffles in this solution can achieve both radial aggregation of materials and full circumferential agitation, which is conducive to full contact between materials and organic solvents and avoids the problem of insufficient local extraction. In addition, the feeding module can adjust the tilt angle of the baffles according to the particle size and flowability of the raw materials, flexibly control the residence time of materials in the filter plate, further improve the extraction rate of tanshinone polyphenols and reduce raw material waste.

[0014] 4. This solution uses a transparent acrylic cover, which allows operators to observe the status of the material inside the shell, changes in liquid level, and extraction status in real time, enabling them to monitor production without stopping the machine. Furthermore, the cover and discharge module are connected by screws, making disassembly simple and facilitating subsequent cleaning and component maintenance, thus balancing functionality and practicality. Attached Figure Description

[0015] Figure 1 This is a perspective view of the present invention; Figure 2This is a rear view of the present invention; Figure 3 This is a schematic diagram of the internal structure of the present invention; Figure 4 This is a schematic diagram of the assembly of the housing and the partition plate of the present invention; Figure 5 This is an assembly diagram of the material discharge module, the material pusher module, and the cover plate of the present invention; Figure 6 This is a schematic diagram of the filter plate structure of the present invention; Figure 7 This is a cross-sectional view of the filter plate of the present invention; Figure 8 This is a perspective view of the feeding module of the present invention; Figure 9 This is a perspective view of the material discharge module of the present invention; Legend: 1. Shell; 2. Liquid inlet; 3. Liquid outlet; 4. Feed inlet; 5. Discharge module; 6. Filter plate; 7. Pushing module; 8. Partition; 9. Water inlet; 10. Water outlet; 11. Cover plate; 12. Hopper; 13. Vertical plate; 14. Short shaft; 15. Flat plate; 16. Oblong hole; 17. Flywheel; 18. Roller; 19. Baffle; 20. Baffle; 21. Round rod; 22. Turntable; 23. Round tube; 24. Bolt; 25. Filter cartridge; 26. Relief groove; 27. Cylinder; 28. Round tank; 29. ​​Screw; 30. Discharge port. Detailed Implementation

[0016] Embodiments of the present invention are described in detail below, examples of which are illustrated in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain the present invention, and should not be construed as limiting the present invention.

[0017] In the description of this invention, "a plurality of" means two or more, unless otherwise explicitly specified.

[0018] Reference Figure 1 , Figure 2 and Figure 3 One embodiment shown includes a housing 1, which is square in shape. A U-shaped partition 8 is provided inside the housing 1. The partition 8 is welded and fixed to the housing 1, and a gap is left between the housing 1 and the partition 8. The side wall of the partition 8 is provided with an inlet 2 and an outlet 3, both of which extend out of the housing 1. The outer wall of the housing 1 is provided with a water inlet 9 and an outlet 10. The partition 8 isolates the filter plate 6 from the water inlet 9. The top of the housing 1 has an opening, and a cover plate 11 is provided above the opening. The cover plate 11 is fixed to the housing 1 by screws. The cover plate 11 has a feed inlet 4 and a discharge module 5. A hopper 12 is provided above the feed inlet 4. The discharge module 5 is fixed to the cover plate 11. The cover plate 11 is made of a transparent material, such as acrylic. The inner cavity of the housing 1 is provided with an arc-shaped filter plate 6. The central angle of the filter plate 6 is greater than 180 degrees. Vertical plates 13 are fixed on both sides of the filter plate 6. A short shaft 14 is fixed to the outer end of the vertical plate 13. The two ends of the short shaft 14 are connected to the side wall of the housing 1 through bearings. A flat plate 15 is welded below the short shaft 14 on one side. An elongated hole 16 is opened on the flat plate 15 along the vertical direction. A drive motor is provided on the outside of the housing 1. A flywheel 17 is fixed on the output shaft of the drive motor. A roller 18 is fixed on the flywheel 17. The axis of the roller 18 is parallel to the axis of the output shaft of the drive motor and is not collinear. The roller 18 is always located in the elongated hole 16. The arc-shaped opening on the filter plate 6 faces the feed inlet 4. The bottom of the discharge module 5 extends into the columnar cavity of the filter plate 6, and the top of the discharge module 5 extends out of the housing 1. Multiple pusher modules 7 are provided in the cavity of the filter plate 6 between the feed inlet 4 and the discharge module 5. The pusher modules 7 are connected to the top wall of the housing 1. The pusher modules 7 can change the axial movement speed of the material on the filter plate 6.

[0019] In the above embodiment, an organic solvent for extraction, such as methanol, is first introduced into the inner cavity of the partition 8 through the liquid inlet 2, ensuring that the organic solvent does not spill out when the filter plate 6 rotates. Subsequently, the organic solvent is discharged from the liquid outlet 3. At the same time, a circulating heat transfer medium, such as constant temperature water or heat transfer oil, is introduced into the gap between the partition 8 and the shell 1 through the water inlet 9 and the water outlet 10. The heat transfer medium circulation system is then started, and the temperature of the heat transfer medium is adjusted according to the appropriate temperature for the extraction of tanshinone polyphenols, so that the extraction environment temperature inside the shell 1 is stabilized within the set range. Finally, the pretreated tanshinone raw material is fed into the feed inlet 4 through the hopper 12 on the cover plate 11. The raw material passes through the feed inlet 4 and falls into the arc-shaped cavity of the filter plate 6.

[0020] The drive motor on the outside of the housing 1 is started, which drives the flywheel 17 to rotate. The roller 18 on the flywheel 17 slides in the elongated hole 16 of the plate 15, thereby driving the filter plate 6 to reciprocate around the short axis 14. The greater the distance between the axis of the roller 18 and the flywheel 17, the greater the rotation angle of the filter plate 6. During the reciprocating rotation of the filter plate 6, the pushing module 7 pushes the material to move towards the discharge module 5. When the filter plate 6 reciprocates, the flow direction of the organic solvent and the material is opposite, ensuring that the material and the solvent are fully mixed and the tanshinone polyphenols gradually dissolve in the solvent. Finally, when the material moves to the bottom of the discharge module 5, it is carried out of the housing 1 by the discharge module 5.

[0021] Furthermore, the reaction state inside the housing 1 can be observed through the transparent cover 11 throughout the entire process, allowing for timely adjustments to the production information. After production is completed, the cover 11 can be removed with screws for easy cleaning or maintenance.

[0022] Reference Figure 6 and Figure 7 In one embodiment shown, a plurality of baffles 19 are fixed on the inner wall of the filter plate 6. The length direction of the baffles 19 is parallel to the axis of the filter plate 6. The cross-sectional shape of the baffles 19 is a right trapezoid, and the right-angled sidewalls of all the baffles 19 face one direction.

[0023] In the above embodiment, when the filter plate 6 rotates in the direction of the inclined surface on the baffle 19, the inclined surface on the baffle can push the material radially towards the axis, causing the mixture of material and organic solvent to converge towards the axis of the filter plate 6; when the filter plate 6 rotates in the direction of the right-angle side wall of the baffle 19, the baffle can push the material circumferentially, causing the mixture of material and organic solvent to accumulate in one direction along the inner wall of the filter plate 6, and then fall from the highest point to the center of the filter plate 6, realizing the stirring of the material in multiple directions and ensuring that the material and organic solvent are in full contact.

[0024] Reference Figure 5 and Figure 8 In one embodiment shown, the feeding module 7 includes a baffle 20 located inside the filter plate 6 and perpendicular to the axis of the filter plate 6. The horizontal cross-sectional shape of the filter plate 6 is arc-shaped. A round rod 21 is fixed to the top of the filter plate 6. The top of the round rod 21 extends out of the housing 1 and is welded with a turntable 22. A round tube 23 is fixed to the top of the housing 1. The round tube 23 is coaxial with the round rod 21 and has a threaded hole. A bolt 24 is provided in the threaded hole.

[0025] In the above embodiment, if the material particles are small, the plane on the baffle 20 is perpendicular to the axis of the filter plate 6. When the filter plate 6 reciprocates, the material is always pushed towards the discharge module 5 by the arc-shaped surface, and the plane has no effect. If the material particles are large, the leaching time of the material needs to be extended. Therefore, the plane on the baffle 20 is set at an acute angle to the axis of the filter plate 6. When the filter plate 6 reciprocates, the material is still pushed towards the discharge module 5 by the arc-shaped surface, but the flat plate 15 will also move the material towards the feed inlet 4. Therefore, the moving speed of the material is related to the tilt angle of the baffle 20. The larger the tilt angle, the slower the material moves towards the discharge module 5, until the projection area of ​​the arc-shaped surface and the plane on the front wall of the shell 1 completely coincides. The baffle 20 can only provide a stirring effect, and the material cannot move along the axis of the filter plate 6 under the push of the baffle 20. The tilt angle of the baffle 20 can be adjusted by loosening the bolt 24 and then rotating the turntable 22. After determining the angle of the baffle 20, tighten the bolt 24 to fix it to the round rod 21 to prevent the material from pushing the baffle 20 to rotate.

[0026] Reference Figure 4 , Figure 5 and Figure 9 In one embodiment shown, the discharge module 5 includes a filter cylinder 25 located inside the housing 1 with its axis in the vertical direction. The bottom of the filter cylinder 25 extends into the inner cavity of the filter plate 6 and has multiple clearance grooves 26. A cylinder 27 is fixed to the top of the filter cylinder 25 and is fixed to the top wall of the housing 1 by screws. The top of the cylinder 27 extends above the housing 1. A cylindrical tank 28 is fixed to the top of the cylinder 27. The diameter of the cylindrical tank 28 is larger than that of the cylinder 27, and the inner cavities of the cylindrical tank 28, the cylinder 27, and the filter cylinder 25 are connected. An auger 29 is coaxially arranged inside the filter cylinder 25. The upper end of the auger 29 extends into the inner cavity of the cylindrical tank 28. The shaft of the auger 29 passes through the top of the cylindrical tank 28 and is connected to a servo motor. The servo motor is fixed to the top wall of the cylindrical tank 28. A discharge port 30 is provided on the side wall of the cylindrical tank 28.

[0027] In the above embodiment, the material enters the filter cartridge 25 from the relief groove 26. The servo motor drives the auger 29 to rotate, which lifts the material into the round tank 28. During the lifting process, the material will be squeezed. The squeezed organic solvent flows back into the inner cavity of the baffle 8 through the filter holes on the filter cartridge 25, and the material residue is discharged from the discharge port 30.

Claims

1. A device for extracting and separating tanshinone polyphenols, characterized in that, Includes a housing (1), with an inlet (2) and an outlet (3) on the side wall of the housing (1), a feed inlet (4) and a discharge module (5) on the top of the housing (1), and an arc-shaped filter plate (6) in the inner cavity of the housing (1). The filter plate (6) can rotate back and forth around the axis in the housing (1). The arc-shaped opening on the filter plate (6) faces the feed inlet (4). The bottom of the discharge module (5) extends into the columnar cavity of the filter plate (6), and the top of the discharge module (5) extends out of the housing (1). Multiple pusher modules (7) are provided in the cavity of the filter plate (6) between the feed inlet (4) and the discharge module (5). The pusher modules (7) are connected to the top wall of the housing (1). The pusher modules (7) can change the axial movement speed of the material on the filter plate (6).

2. The apparatus according to claim 1, characterized in that, The shell (1) is square in shape. A U-shaped partition (8) is provided inside the shell (1). The partition (8) is welded and fixed to the shell (1). There is a gap between the shell (1) and the partition (8). The liquid inlet (2) and the liquid outlet (3) are connected to the inner cavity of the partition (8). The outer wall of the shell (1) is provided with a water inlet (9) and a water outlet (10). The partition (8) isolates the filter plate (6) from the water inlet (9).

3. The apparatus according to claim 1, characterized in that, The shell (1) has an opening at the top, and a cover plate (11) is provided above the opening. The cover plate (11) is fixed to the shell (1) by screws. The feed inlet (4) is located on the cover plate (11). A hopper (12) is provided above the feed inlet (4). The discharge module (5) is fixed to the cover plate (11). The cover plate (11) is made of transparent material.

4. The apparatus according to claim 1, characterized in that, The central angle of the filter plate (6) is greater than 180 degrees. Vertical plates (13) are fixed on both sides of the filter plate (6). A short shaft (14) is fixed at the outer end of the vertical plate (13). The two ends of the short shaft (14) are connected to the side wall of the housing (1) through bearings. A flat plate (15) is welded below the short shaft (14) on one side. An elongated hole (16) is opened on the flat plate (15) along the vertical direction. A drive motor is provided on the outside of the housing (1). A flywheel (17) is fixed on the output shaft of the drive motor. A roller (18) is fixed on the flywheel (17). The axis of the roller (18) is parallel to and not collinear with the axis of the output shaft of the drive motor. The roller (18) is always located in the elongated hole (16).

5. The apparatus according to claim 1, characterized in that, The filter plate (6) has multiple baffles (19) fixed on its inner wall. The length direction of the baffles (19) is parallel to the axis of the filter plate (6). The cross-sectional shape of the baffles (19) is a right trapezoid, and the right-angled sidewalls of all the baffles (19) face one direction.

6. The apparatus according to claim 1, characterized in that, The pusher module (7) includes a baffle (20), which is located in the inner cavity of the filter plate (6) and perpendicular to the axis of the filter plate (6). The horizontal cross-section of the filter plate (6) is arc-shaped. A round rod (21) is fixed on the top of the filter plate (6). The top of the round rod (21) extends out of the housing (1) and is welded with a turntable (22). A round tube (23) is fixed on the top of the housing (1). The round tube (23) is coaxial with the round rod (21) and has a threaded hole. A bolt (24) is provided in the threaded hole.

7. The apparatus according to claim 1, characterized in that, The discharge module (5) includes a filter cylinder (25), which is located inside the housing (1) with its axis in the vertical direction. The bottom of the filter cylinder (25) extends into the inner cavity of the filter plate (6) and has multiple clearance grooves (26). A cylinder (27) is fixed to the top of the filter cylinder (25). The cylinder (27) is fixed to the top wall of the housing (1) by screws. The top of the cylinder (27) extends above the housing (1). A cylindrical container (28) is fixed to the top of the cylinder (27). The diameter of the round tank (28) is larger than that of the cylindrical tank (27), and the inner cavities of the round tank (28), the cylindrical tank (27) and the filter cylinder (25) are connected. The filter cylinder (25) is coaxially equipped with an auger (29). The upper end of the auger (29) extends into the inner cavity of the round tank (28). The shaft of the auger (29) passes through the top of the round tank (28) and is connected to a servo motor. The servo motor is fixed to the top wall of the round tank (28). The side wall of the round tank (28) is equipped with a discharge port (30).

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