A self-drying gel, and a preparation method and application thereof
By preparing a self-drying gel, the problems of adhesion and insufficient absorption of exudate in traditional dressings are solved, providing anti-adhesion and high immunocompatibility, promoting wound healing and reducing secondary damage.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- NANJING NORMAL UNIVERSITY
- Filing Date
- 2026-03-02
- Publication Date
- 2026-05-12
AI Technical Summary
Traditional wound dressings tend to stick to the wound surface when changed, causing secondary mechanical damage, and have limited ability to absorb exudate, which affects wound healing.
A self-drying gel is prepared from raw materials such as cationic imidazole salt, dopamine hydrochloride, carboxyam zwitterionic monomers and carboxy chitosan. The self-drying gel is formed through a cross-linking reaction, and a flexible membrane is prepared for wound covering.
Self-drying gels have anti-adhesion and high immunocompatibility, can form a closed and moist environment on the wound surface, reduce secondary damage, promote healing, and have good adhesion and tensile properties.
Smart Images
Figure CN121754720B_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The present application belongs to the technical field of medical gel dressings, and relates to a self-drying gel and a preparation method and application thereof. BACKGROUND
[0002] Traditional wound dressings (such as gauze, cotton pad, oil gauze, etc.) are mostly inert dressings, which mainly play a covering and protective role on the wound. However, the absorption capacity of exudate is limited, and the dressing is easy to adhere to the wound surface. When replaced, the adhered dressing is easy to cause mechanical damage to the newly generated tissue, causing pain, bleeding, and delaying wound healing.
[0003] Compared with the limitations of traditional solid dressings (such as gauze, sheet-shaped hydrogel, etc.) in terms of fitting irregular wound surfaces, managing exudate, and avoiding damage during replacement, the self-drying flexible dressing (usually in the form of hydrogel) can exhibit significant advantages. It can form in situ and perfectly fit the complex wound surface topography; the closed and moist environment it provides helps cell migration, which can accelerate healing and reduce pain; at the same time, good air permeability and transparency facilitate wound observation. For severe wounds such as burns, frequent mechanical debridement and replacement of solid dressings can easily cause secondary damage, and the coatable dressing is expected to reduce such damage.
[0004] Therefore, developing a new type of gel dressing with the characteristics of coatable forming, in-situ self-drying, anti-adhesion, and good biocompatibility, so as to achieve perfect fitting and protection of the wound surface and minimize secondary damage during replacement, has become an important research direction in the field of wound care. SUMMARY
[0005] The technical problem to be solved by the present application is to overcome the shortcomings in the prior art, and to provide a self-drying gel and a preparation method and application thereof. The self-drying gel provided by the present application has the advantages of anti-adhesion and high immune compatibility, so that it is not easy to cause secondary damage during clinical replacement. The self-drying gel flexible film prepared from the self-drying gel has the advantages of strong plasticity, good fitting, and effective sealing of the wound.
[0006] To solve the above technical problems, the technical solution adopted by the present application is:
[0007] The present application provides a self-drying gel, the preparation raw materials of the self-drying gel comprising: a cationic imidazole salt, dopamine hydrochloride, a carboxybetaine zwitterionic monomer, and carboxymethyl chitosan.
[0008] Preferably, the cationic imidazole salt is selected from one or more of 1-butyl-2,3-dimethylimidazole chloride, 1-ethyl-3-methylimidazole chloride, 1-ethyl-3-methylimidazole bromide, and 1-butyl-3-methylimidazole chloride;
[0009] And / or, the carboxybetaine zwitterionic monomer is selected from carboxybetaine;
[0010] And / or, the carboxybetaine is selected from one or more of carboxybetaine methacrylate, acryloyl ethyl carboxybetaine.
[0011] And / or, the carboxybetaine is selected from one or more of carboxybetaine methacrylate, acryloyl ethyl carboxybetaine.
[0012] Preferably, the raw material further comprises: an initiator;
[0013] And / or, the initiator is selected from aromatic ketone compounds.
[0014] And / or, the aromatic ketone compound is selected from one or more of 2-hydroxy-2-methyl-1-phenyl-1-propanone, 2-hydroxy-4-(2-hydroxyethoxy)-2-methylpropiophenone.
[0015] Preferably, the raw material further comprises: a crosslinking agent;
[0016] And / or, the crosslinking agent is selected from one or more of polyethylene glycol diacrylate, N,N'-methylene bisacrylamide.
[0017] Preferably, the molar ratio of the cationic imidazole salt, dopamine hydrochloride, carboxybetaine zwitterionic monomer and carboxybetaine chitosan is (1-2):(1-2):(5-15):(1-10).
[0018] And / or, the cationic imidazole salt is added in the form of an aqueous solution, and the concentration of the cationic imidazole salt in the aqueous solution is 0.01 mol / L-0.05 mol / L.
[0019] And / or, the amount of the initiator is 0.1%-0.5% of the molar amount of the carboxybetaine zwitterionic monomer and the cationic imidazole salt.
[0020] And / or, the amount of the crosslinking agent is 0.1%-0.5% of the molar amount of the carboxybetaine zwitterionic monomer and the carboxybetaine chitosan.
[0021] The present application also provides a preparation method of the self-drying gel described above, comprising the following steps:
[0022] S1, the cationic imidazole salt, dopamine hydrochloride, carboxybetaine zwitterionic monomer, carboxybetaine chitosan, initiator, crosslinking agent, crosslinking, to obtain a self-drying gel.
[0023] Preferably, the step S1 further comprises the following steps:
[0024] S1a. Crosslinking cationic imidazole salt, dopamine hydrochloride, carboxyam amphoteric monomer, carboxy chitosan, initiator, and crosslinking agent to obtain a self-drying gel aqueous solution; adding the dried product of the self-drying gel aqueous solution to water and mixing, wherein the volume ratio of the dried product to water is 1:(0.5~2), to obtain a self-drying gel.
[0025] And / or, the crosslinking reaction temperature is 40℃~60℃, and the reaction time is 1~5 hours;
[0026] And / or, the crosslinking is carried out under light irradiation, wherein the light irradiation is ultraviolet light with a wavelength of 260nm~390nm;
[0027] And / or, in step S1a, the drying is to dry the self-drying gel aqueous solution to a water content of less than 3%.
[0028] The present invention also provides a self-drying gel flexible membrane, wherein the preparation method of the self-drying gel flexible membrane includes the following steps:
[0029] S2. Coating and drying the self-drying gel prepared by any of the above-described self-drying gel preparation methods to obtain a self-drying gel flexible film.
[0030] Preferably, in step S2, the drying conditions are a temperature of 30°C to 40°C and a relative humidity of 60% to 80%.
[0031] And / or, in step S2, the drying is to dry the self-drying gel to a water content of less than 10%;
[0032] And / or, the maximum strain of the self-drying gel flexible membrane is 621% to 852%;
[0033] And / or, the maximum stress of the self-drying gel flexible membrane is 3252 kPa to 269 kPa.
[0034] Preferably, step S2 further includes the following steps:
[0035] The self-drying gel prepared by any of the above-described self-drying gel methods is dried at a temperature of 37°C and a relative humidity of 70% to form a self-drying gel flexible film with a water content of less than 5%.
[0036] The present invention also provides the application of the self-drying gel described in any one of the above claims, or the self-drying gel obtained by any one of the above claims, or the self-drying gel flexible membrane described in any one of the above claims, in the preparation of medical wound dressings.
[0037] Due to the adoption of the above technical solutions, the present invention has the following advantages compared with the prior art:
[0038] The self-drying gel provided by this invention combines the advantages of being coatable and moldable, self-drying in situ, anti-adhesion, good biocompatibility, and high immunocompatibility, making it less likely to cause secondary damage during clinical use and promoting wound healing by regulating the immune response. The self-drying gel flexible membrane prepared from this gel also possesses high plasticity, good adhesion, effectively seals wounds, and has good tensile properties, allowing it to move with body tissues after being applied to the wound surface. Attached Figure Description
[0039] Figure 1 The self-drying gel sample prepared in Example 1;
[0040] Figure 2 The sample of the self-drying gel prepared in Example 1 was left to stand naturally for 2 hours at a temperature of 37°C and a relative humidity of 70%.
[0041] Figure 3 To test the effects of the self-drying gel prepared in Example 1 of Test Example 2 and the chitosan gel prepared in Comparative Example 1 on four pro-inflammatory cytokines: TNF-α, CCR-7, IL-6, and IL-17. Detailed Implementation
[0042] To make the technical solution and beneficial effects of the present invention more apparent and understandable, a detailed description is provided below in conjunction with the accompanying drawings and specific embodiments. The drawings are not necessarily drawn to scale, and local features may be enlarged or reduced to more clearly show the details of the local features; unless otherwise defined, the technical and scientific terms used herein have the same meanings as those in the technical field to which this application pertains.
[0043] The present invention provides a self-drying gel, wherein the raw materials for preparing the self-drying gel include: cationic imidazole salt, dopamine hydrochloride, carboxyam zwitterionic monomer and carboxychitosan.
[0044] In some embodiments, the cationic imidazole salt is selected from one or more of 1-butyl-2,3-dimethylimidazolium chloride, 1-ethyl-3-methylimidazolium chloride, 1-ethyl-3-methylimidazolium bromide, and 1-butyl-3-methylimidazolium chloride.
[0045] In some embodiments, the cationic imidazole salt is selected from 1-butyl-2,3-dimethylimidazolium chloride.
[0046] In some embodiments, the carboxyam zwitterionic monomer is selected from carboxylic acid betaine.
[0047] In some embodiments, the carboxylic acid betaine is selected from one or more of carboxymethyl methacrylate betaine and acryloylethyl carboxymethyl betaine.
[0048] In some embodiments, the carboxylated chitosan is selected from O-carboxymethyl chitosan, N-carboxymethyl chitosan, and N,O-carboxymethyl chitosan.
[0049] In some embodiments, the carboxylated chitosan is selected from N-carboxymethyl chitosan.
[0050] In some embodiments, the raw material further includes an initiator.
[0051] In some embodiments, the initiator is selected from aromatic ketone compounds.
[0052] In some embodiments, the aromatic ketone compound is selected from one or more of 2-hydroxy-2-methyl-1-phenyl-1-propanone and 2-hydroxy-4-(2-hydroxyethoxy)-2-methylphenylpropanone.
[0053] In some embodiments, the aromatic ketone compound is selected from 2-hydroxy-2-methyl-1-phenyl-1-propanone.
[0054] In some embodiments, the raw material further includes a crosslinking agent.
[0055] In some embodiments, the crosslinking agent is selected from one or more of polyethylene glycol diacrylate and N,N′-methylenebisacrylamide.
[0056] In some embodiments, the crosslinking agent is selected from N,N′-methylenebisacrylamide.
[0057] In some embodiments, the molar ratio of the cationic imidazole salt, dopamine hydrochloride, carboxyamium zwitterionic monomer, and carboxychitosan is (1-2):(1-2):(5-15):(1-10), for example, 1:1:5:1, 1:1:5:2, 1:1:5:3, 1:1:5:4, 1:1:5:5, 1:1:5:6, 1:1:5:7, 1:1:5:8, 1:1:5:9, 1:1:5:10, 1:1:6:1, 1:1:6:2, 1:1:6:3, 1:1:6:4, 1:1:6:5, 1:1:6:6, 1:1:6:7, 1:1:6:8, 1:1:6:9, 1:1:6:10, 1:1:7:1, 1:1:7: 2, 1:1:7:3, 1:1:7:4, 1:1:7:5, 1:1:7:6, 1:1:7:7, 1:1:7:8, 1:1:7:9, 1:1:7:10, 1:1:8:1, 1:1:8:2, 1:1:8:3, 1:1:8:4, 1:1:8:5, 1:1:8:6, 1:1:8:7, 1 :1:8:8、1:1:8:9、1:1:8:10、1:1:9:1、1:1:9:2、1:1:9:3、1:1:9:4、1:1:9:5、1:1:9:6、1:1:9:7、1:1:9:8、1:1:9:9、1:1:9:10、1:1:10:1、1:1:10:2、1: 1:10:3, 1:1:10:4, 1:1:10:5, 1:1:10:6, 1:1:10:7, 1:1:10:8, 1:1:10:9, 1:1:10:10, 1:1:11:1, 1:1:11:2, 1:1:11:3, 1:1:11:4, 1:1:11:5, 1:1:11:6 1:1:11:7, 1:1:11:8, 1:1:11:9, 1:1:11:10, 1:1:12:1, 1:1:12:2, 1:1:12:3, 1:1:12:4, 1:1:12:5, 1:1:12:6, 1:1:12:7, 1:1:12:8, 1:1:12:9, 1:1:12 :10、1:1:13:1、1:1:13:2、1:1:13:3、1:1:13:4、1:1:13:5、1:1:13:6、1:1:13:7、1:1:13:8、1:1:13:9、1:1:13:10、1:1:14:1、1:1:14:2、1:1:14:3、1: 1:14:4, 1:1:14:5, 1:1:14:6, 1:1:14:7, 1:1:14:8, 1:1:14:9, 1:1:14:10, 1:1:15:1, 1:1:15:2, 1:1:15:3, 1:1:15:4, 1:1:15:5, 1:1:15:6, 1:1:15:71:1:15:8, 1:1:15:9, 1:1:15:10, 2:2:5:1, 2:2:5:2, 2:2:5:3, 2:2:5:4, 2:2:5:5, 2:2:5:6, 2:2:5:7, 2:2:5:8, 2:2:5:9, 2:2:5:10, 2:2:15:1, 2:2:15:2, 2:2:15:3, 2:2:15:4, 2:2:15:5, 2:2:15:6, 2:2:15:7, 2:2:15:8, 2:2:15:9, 2:2:15:10, etc.
[0058] In some embodiments, the cationic imidazole salt is added in the form of an aqueous solution, wherein the concentration of the cationic imidazole salt in the aqueous solution is 0.01 mol / L to 0.05 mol / L, for example, 0.01 mol / L, 0.02 mol / L, 0.03 mol / L, 0.04 mol / L, 0.05 mol / L, etc.
[0059] In some embodiments, the cationic imidazole salt is added in the form of an aqueous solution, wherein the concentration of the cationic imidazole salt in the aqueous solution is 0.01 mol / L.
[0060] In some embodiments, the amount of the initiator is 0.1% to 0.5% of the molar amount of the carboxyam zwitterionic monomer and the cationic imidazole salt, for example, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, etc.
[0061] In some embodiments, the amount of the initiator is 0.1% of the molar amount of the carboxyam zwitterionic monomer and the cationic imidazole salt.
[0062] In some embodiments, the amount of the crosslinking agent is 0.1% to 0.5% of the molar amount of the carboxyam amphoteric monomer and the carboxychitosan, for example, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, etc.
[0063] In some embodiments, the amount of the crosslinking agent is 0.1% of the molar amount of the carboxyam amphoteric monomer and the carboxychitosan.
[0064] The present invention also provides a method for preparing the above-described self-drying gel, comprising the following steps:
[0065] S1. Crosslinking of cationic imidazole salt, dopamine hydrochloride, carboxyam zwitterionic monomer, carboxy chitosan, initiator, and crosslinking agent to obtain a self-drying gel.
[0066] In some embodiments, step S1 further includes the following steps:
[0067] S1a. Crosslinking is performed on cationic imidazole salt, dopamine hydrochloride, carboxyam amphoteric monomer, carboxylated chitosan, initiator, and crosslinking agent to obtain a self-drying gel aqueous solution. The dried product of the self-drying gel aqueous solution is then added to water and mixed, with the volume ratio of the dried product to water being 1:(0.5~2), to obtain a self-drying gel. The step of adding the dried product of the self-drying gel aqueous solution to water is primarily for accurately measuring the amount of water used and controlling the ratio of the dried product to water, facilitating the preparation of a coatable self-drying gel flexible membrane.
[0068] In some embodiments, in step S1a, the drying is oven drying, natural drying, or freeze drying.
[0069] In some embodiments, the drying in step S1a is oven drying.
[0070] In some embodiments, the crosslinking reaction temperature is 40°C to 60°C, for example, 40°C, 45°C, 50°C, 55°C, 60°C, etc.; the reaction time is 1 to 5 hours, for example, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, etc.
[0071] In some embodiments, the crosslinking is carried out under light irradiation, which is ultraviolet light with a wavelength of 260nm to 390nm, such as 260nm, 270nm, 280nm, 290nm, 300nm, 310nm, 320nm, 330nm, 340nm, 350nm, 360nm, 370nm, 380nm, 390nm, etc.
[0072] In some embodiments, the crosslinking is carried out under light irradiation, wherein the light irradiation is ultraviolet light with a wavelength of 350 nm to 370 nm.
[0073] In some embodiments, the crosslinking is carried out under light irradiation, wherein the light irradiation is ultraviolet light at a wavelength of 360 nm.
[0074] In some embodiments, in step S1a, the drying is to dry the self-drying gel aqueous solution to a water content of less than 3%, for example, 3%, 2.5%, 2%, 1.5%, 1%, etc.
[0075] In some embodiments, in step S1a, the drying is to dry the self-drying gel aqueous solution to a water content of less than 1%.
[0076] In some embodiments, in step S1a, the drying is oven drying, natural drying, or freeze drying.
[0077] The present invention also provides a self-drying gel flexible membrane, wherein the preparation method of the self-drying gel flexible membrane includes the following steps:
[0078] S2. Coating and drying the self-drying gel prepared by any of the above-described self-drying gel preparation methods to obtain a self-drying gel flexible film.
[0079] In some embodiments, in step S2, the drying conditions are a temperature of 30°C to 40°C, for example, 30°C, 31°C, 32°C, 33°C, 34°C, 35°C, 36°C, 37°C, 38°C, 39°C, 40°C, etc.; and a relative humidity of 60% to 80%, for example, 60%, 65%, 70%, 75%, 80%, etc.
[0080] In some embodiments, in step S2, the drying conditions are a temperature of 35°C to 39°C and a relative humidity of 65% to 75%.
[0081] In some embodiments, in step S2, the drying is to dry the self-drying gel to a moisture content of less than 10%, for example, 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1%, etc.
[0082] In some embodiments, in step S2, the drying process involves drying the self-drying gel to a moisture content of less than 5%.
[0083] In some embodiments, in step S2, the drying is oven drying, natural drying, or freeze drying.
[0084] In some embodiments, the maximum strain of the self-drying gel flexible membrane is 621% to 852%.
[0085] In some embodiments, the maximum stress of the self-drying gel flexible membrane is 3252 kPa to 269 kPa.
[0086] In some embodiments, step S2 further includes the following steps:
[0087] The self-drying gel prepared by any of the above-described self-drying gel methods is dried at a temperature of 37°C and a relative humidity of 70% to form a self-drying gel flexible film with a water content of less than 5%.
[0088] The present invention also provides the application of the self-drying gel described in any one of the above claims, or the self-drying gel obtained by any one of the above claims, or the self-drying gel flexible membrane described in any one of the above claims, in the preparation of medical wound dressings.
[0089] It should be understood that these embodiments are for illustrative purposes only and are not intended to limit the scope of the invention. Experimental methods in the following embodiments, unless otherwise specified, are generally performed under conventional experimental conditions. Unless otherwise specified, all reagents and raw materials used in this invention are commercially available.
[0090] Example 1
[0091] Step S11: Weigh 0.189 g of 1-butyl-2,3-dimethylimidazolium chloride (0.001 mol), add 100 mL of water to prepare a 0.01 mol / L solution, add 0.19 g of dopamine hydrochloride (0.001 mol), 2.59 g of the zwitterionic monomer carboxybetaine methacrylate (0.011 mol), 2.1 g of N-carboxymethyl chitosan (0.004 mol), 0.0155 g of N,N'-methylenebisacrylamide (1% of the molar amount of the zwitterionic monomer), and 0.016 g of... 2-Hydroxy-2-methyl-1-phenyl-1-propanone (1% of the molar amount of the zwitterionic monomer) was placed in a 25 mL beaker, stirred, irradiated with a 360 nm UV lamp, reacted at 60 °C for 2 hours to obtain a self-drying gel aqueous solution; the self-drying gel aqueous solution was dried to a water content of less than 1%, and then mixed with water at a volume ratio of 1:0.5 to obtain a self-drying gel.
[0092] Step S12: Inject the self-drying gel into two 5*2cm glass plates using a syringe, with a thickness of 2mm between the glass plates. After injection, dry the gel at 37℃ and 70% relative humidity for 30 minutes until a self-drying gel flexible film with a moisture content of less than 5% is formed.
[0093] Example 2
[0094] Step S21: Weigh 0.189 g of 1-butyl-2,3-dimethylimidazolium chloride (0.001 mol), add 100 mL of water to prepare a 0.01 mol / L solution, add 0.19 g of dopamine hydrochloride (0.001 mol), 2.59 g of zwitterionic monomer carboxybetaine methacrylate (0.011 mol), 2.1 g of N-carboxymethyl chitosan (0.004 mol), 0.0155 g of N,N'-methylenebisacrylamide (1% of the molar amount of the zwitterionic monomer), and 0.016 g of... 2-Hydroxy-2-methyl-1-phenyl-1-propanone (1% of the molar amount of the zwitterionic monomer) was placed in a 25 mL beaker, stirred, irradiated with a 360 nm UV lamp, reacted at 60 °C for 2 hours to obtain a self-drying gel aqueous solution; the self-drying gel aqueous solution was dried to a water content of less than 1%, and then mixed with water at a volume ratio of 1:2 to obtain a self-drying gel.
[0095] Step S22: Inject the self-drying gel into two 5*2cm glass plates using a syringe, with a thickness of 2mm between the glass plates. After injection, dry the gel at 37℃ and 70% relative humidity for 30 minutes until a self-drying gel flexible film with a moisture content of less than 5% is formed.
[0096] Comparative Example 1
[0097] Weigh 0.189 g of 1-butyl-2,3-dimethylimidazolium chloride (0.001 mol), add 100 mL of water to prepare a 0.01 mol / L solution, add 0.19 g of dopamine hydrochloride (0.001 mol), 2.1 g of N-carboxymethyl chitosan (0.004 mol), 0.155 g of N,N'-methylenebisacrylamide, and 0.016 g of 2-hydroxy-2-methyl-1-phenyl-1-propanone, place in a 25 mL beaker, stir, irradiate with a 360 nm UV lamp, react at 60 °C for 2 hours to obtain a self-drying gel aqueous solution; dry the self-drying gel aqueous solution to a water content of less than 1%, add it to water and mix, with a volume ratio of dried product to water of 1:0.5, to obtain chitosan gel.
[0098] Test Example 1
[0099] The self-drying gel flexible membranes prepared in Examples 1 and 2 were subjected to tensile property tests according to ASTM D882 standard. The equipment was a stress-strain testing machine equipped with clamps to fix the membrane. Before the test, the self-drying gel flexible membranes were cut into dumbbell-shaped specimens of 50mm*20mm*2mm and left to stand for 40 hours under standard temperature and humidity conditions (usually 23±2℃, relative humidity 50±10%).
[0100] The test results are shown in Table 1. The self-drying gel flexible membranes prepared in Examples 1 and 2 have a maximum strain of 621% to 852% and a maximum stress of 3252 kPa to 269 kPa. They have good tensile properties and can move with the body tissue after being covered on the wound surface.
[0101] Table 1 Tensile property test results
[0102]
[0103] Test Example 2
[0104] The self-drying gel prepared in Example 1 and the chitosan gel prepared in Comparative Example 1 were injected subcutaneously into the backs of two-week-old mice (n=5), with each mouse receiving 20 μL. Inflammation was assessed two weeks later. Specifically, immunohistochemical analysis of four typical pro-inflammatory cytokines—TNF-α, CCR-7, IL-6, and IL-17—was performed on mouse tissues. Higher expression levels of pro-inflammatory cytokines indicated more severe inflammation.
[0105] like Figure 3 As shown, compared with the unmodified chitosan gel prepared in Comparative Example 1, the self-drying gel of Example 1 induced a significantly lower release of pro-inflammatory cytokines than the unmodified chitosan gel, indicating that the self-drying gel of Example 1 of this invention has superior immunocompatibility. This self-drying gel exerts an anti-inflammatory effect during wound healing and can promote wound repair by regulating the immune response.
[0106] It should be understood that the above embodiments are exemplary and are not intended to encompass all possible implementations included in the claims. Various modifications and changes can be made to the above embodiments without departing from the scope of this disclosure. Similarly, the various technical features of the above embodiments can be arbitrarily combined to form other embodiments of the present invention that may not be explicitly described. Therefore, the above embodiments only illustrate several implementations of the present invention and do not limit the scope of protection of this patent.
Claims
1. A self-drying gel, characterized in that, The raw materials for preparing the self-drying gel include: cationic imidazole salt, dopamine hydrochloride, carboxyam amphoteric monomers, and carboxylated chitosan. The cationic imidazole salt is selected from one or more of 1-butyl-2,3-dimethylimidazolium chloride, 1-ethyl-3-methylimidazolium chloride, 1-ethyl-3-methylimidazolium bromide and 1-butyl-3-methylimidazolium chloride; The carboxyam-based zwitterionic monomer is selected from carboxylic acid betaine; The carboxylic acid betaine is selected from one or more of carboxymethyl methacrylate betaine and acryloyl ethyl carboxymethyl betaine; The carboxylated chitosan is selected from O-carboxymethyl chitosan, N-carboxymethyl chitosan and N,O-carboxymethyl chitosan; The molar ratio of the cationic imidazole salt, dopamine hydrochloride, carboxyam zwitterionic monomer and carboxy chitosan is (1-2):(1-2):(5-15):(1-10).
2. The self-drying gel according to claim 1, characterized in that, The raw materials also include: initiators.
3. The self-drying gel according to claim 2, characterized in that, The initiator is selected from aromatic ketone compounds.
4. The self-drying gel according to claim 3, characterized in that, The aromatic ketone compound is selected from one or more of 2-hydroxy-2-methyl-1-phenyl-1-propanone and 2-hydroxy-4-(2-hydroxyethoxy)-2-methylphenylpropanone.
5. The self-drying gel according to claim 1, characterized in that, The raw materials also include: crosslinking agents.
6. The self-drying gel according to claim 5, characterized in that, The crosslinking agent is selected from one or more of polyethylene glycol diacrylate and N,N′-methylenebisacrylamide.
7. The self-drying gel according to claim 1, characterized in that, The cationic imidazole salt is added in the form of an aqueous solution, wherein the concentration of the cationic imidazole salt in the aqueous solution is 0.01 mol / L to 0.05 mol / L.
8. The self-drying gel according to claim 2, characterized in that, The amount of the initiator is 0.1% to 0.5% of the molar amount of the carboxyam zwitterionic monomer and the cationic imidazole salt.
9. The self-drying gel according to claim 5, characterized in that, The amount of the crosslinking agent is 0.1% to 0.5% of the molar amount of the carboxyam amphoteric monomer and the carboxy chitosan.
10. A method for preparing the self-drying gel according to any one of claims 1 to 9, characterized in that, Includes the following steps: S1. Crosslinking of cationic imidazole salt, dopamine hydrochloride, carboxyam zwitterionic monomer, carboxy chitosan, initiator, and crosslinking agent to obtain a self-drying gel.
11. The preparation method according to claim 10, characterized in that, Step S1 further includes the following steps: S1a. Crosslinking cationic imidazole salt, dopamine hydrochloride, carboxyam amphoteric monomer, carboxy chitosan, initiator, and crosslinking agent to obtain a self-drying gel aqueous solution; adding the dried product of the self-drying gel aqueous solution to water and mixing, wherein the volume ratio of the dried product to water is 1:(0.5~2), to obtain a self-drying gel.
12. The preparation method according to claim 10, characterized in that, The crosslinking reaction temperature is 40℃~60℃, and the reaction time is 1~5 hours.
13. The preparation method according to claim 10, characterized in that, The crosslinking is carried out under light irradiation, which is ultraviolet light with a wavelength of 260nm~390nm.
14. The preparation method according to claim 11, characterized in that, In step S1a, the drying process involves drying the self-drying gel aqueous solution to a water content of less than 3%.
15. A self-drying gel flexible membrane, characterized in that, The method for preparing the self-drying gel flexible membrane includes the following steps: S2. The self-drying gel prepared by any one of claims 1 to 9 or the self-drying gel prepared by any one of claims 10 to 14 is coated and dried to obtain a self-drying gel flexible film.
16. The self-drying gel flexible membrane according to claim 15, characterized in that, In step S2, the drying conditions are a temperature of 30°C to 40°C and a relative humidity of 60% to 80%.
17. The self-drying gel flexible membrane according to claim 15, characterized in that, In step S2, the drying process involves drying the self-drying gel to a moisture content of less than 10%.
18. The self-drying gel flexible membrane according to claim 15, characterized in that, The maximum strain of the self-drying gel flexible membrane is 621% to 852%.
19. The self-drying gel flexible membrane according to claim 15, characterized in that, The maximum stress of the self-drying gel flexible membrane is 3252 kPa to 269 kPa.
20. The self-drying gel flexible membrane according to claim 15, characterized in that, Step S2 further includes the following steps: The self-drying gel prepared by the self-drying gel preparation method according to any one of claims 1 to 9 or according to any one of claims 10 to 14 is dried at a temperature of 37°C and a relative humidity of 70% to form a self-drying gel flexible film with a water content of less than 5%.
21. The use of the self-drying gel according to any one of claims 1 to 9, or the self-drying gel obtained by the preparation method according to any one of claims 10 to 14, or the flexible membrane of the self-drying gel according to any one of claims 15 to 20, in the preparation of medical wound dressings.