Near-infrared light-emitting AgAuSe quantum dot and room-temperature macro preparation method thereof
This method achieves a one-step synthesis of AgAuSe quantum dots at room temperature, overcoming the problems of complex operation and toxic reagents in existing technologies. It enables efficient and environmentally friendly quantum dot preparation, suitable for bioimaging and near-infrared light-emitting devices.
Patent Information
- Application Number
- CN202610038408.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-01-13
- Publication Date
- 2026-03-31
AI Technical Summary
Existing methods for synthesizing AgAuSe quantum dots are cumbersome, require high temperature and pressure, use toxic reagents, and are difficult to apply on a large scale.
A one-step method for synthesizing AgAuSe quantum dots at room temperature was developed using non-phosphine reagents, simplifying the operation, reducing energy consumption, and making it suitable for mass production.
The synthesized AgAuSe quantum dots exhibit high fluorescence quantum yield, good stability, and biocompatibility, making them suitable for bioimaging and near-infrared light-emitting devices.
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Figure CN121759217A_ABST
Abstract
Description
Technical Field
[0001] This invention belongs to the field of inorganic semiconductor material preparation technology, specifically relating to a near-infrared luminescent AgAuSe quantum dot and its room-temperature mass preparation method. Background Technology
[0002] Near-infrared luminescent quantum dot materials, due to their unique emission wavelengths, have significant application value in near-infrared light-emitting diodes, biofluorescent probes, and photoelectric detection. However, currently widely studied semiconductor quantum dot materials such as PbSe, CdS, and CdSe contain toxic elements such as lead and cadmium, whose biotoxicity and environmental hazards severely limit their practical applications. To overcome these problems, researchers have attempted strategies such as surface coating with non-toxic materials and elemental substitution of lead-based and cadmium-based quantum dots, and are actively exploring low-toxicity or non-toxic alternative materials. Among these, AgAuSe quantum dot materials, which do not contain toxic metal elements and have high fluorescence quantum yields, have attracted considerable attention.
[0003] However, existing methods for synthesizing AgAuSe quantum dots still have significant drawbacks. On the one hand, the synthesis process is cumbersome; current high-temperature synthesis methods rely on high-purity inert gases and high-temperature heating, which greatly increases the difficulty and cost of preparation. Furthermore, the low yield of the cation exchange method limits its large-scale application. On the other hand, the traditional synthesis of AgAuSe quantum dots often requires the use of toxic reagents such as trioctylphosphine (TOP) and tributylphosphine (TBP). These reagents are not only expensive but also sensitive to air, requiring storage in glove boxes, and pose potential hazards to organisms and the environment.
[0004] Therefore, it is particularly urgent to develop a simple, low-energy-consumption, and environmentally friendly method for the mass synthesis of near-infrared AgAuSe quantum dots. This would provide strong support for the development of related technologies and promote the widespread application of this type of material in fields such as in vivo biological imaging, fluorescent surgical navigation, and near-infrared light-emitting device fabrication. Summary of the Invention
[0005] To address the issues of toxicity, cost, and scalability in existing technologies for preparing near-infrared luminescent AgAuSe quantum dots, this invention provides a method for their large-scale preparation at room temperature. This invention utilizes a simple one-step method to synthesize AgAuSe quantum dots. The reaction reagents used can be stably stored in air, the reaction process does not require inert gas protection, the operation is simple, the required reaction temperature is low, the reaction time is short, and batch preparation is possible. The semiconductor quantum dot fluorescent materials obtained using this method exhibit good optical and thermal stability and high fluorescence quantum yield, making them promising for applications in in vivo biological imaging and the fabrication of near-infrared light-emitting diodes.
[0006] This invention is achieved through the following technical solution:
[0007] A method for the room-temperature mass production of near-infrared luminescent AgAuSe quantum dots, comprising the following steps:
[0008] Step 1: Prepare the precursor solution;
[0009] The silver source was added to a mixed solution of aliphatic amine and organic solvent, and stirred to disperse, thus obtaining a silver precursor solution.
[0010] The selenium source was dissolved in a mixed solution of aliphatic amine and alkyl thiol to obtain a selenium precursor solution.
[0011] The gold source was dispersed in an organic solvent to obtain a gold precursor solution;
[0012] Step 2: Synthesize quantum dots;
[0013] The silver precursor solution, selenium precursor solution, and gold precursor solution were mixed and reacted with stirring at room temperature. The insoluble precipitate was removed by centrifugation to obtain near-infrared luminescent AgAuSe quantum dots.
[0014] Further, the silver source is selected from one or more of silver trifluoromethanesulfonate, silver acetylacetone, silver lactate, silver citrate, silver stearate, or silver quantum dots; the selenium source is selected from one or more of selenite, potassium selenite, zinc selenite, potassium selenate, selenourea, N,N-dimethylselenourea, or selenium quantum dots; and the gold source is selected from one or more of potassium chloroaurate, ammonium chloroaurate, gold acetate, gold bromide, gold iodide, gold clusters, or gold quantum dots.
[0015] Furthermore, the alkyl thiol is selected from one or more of octanedithiol, decanethiol, tetradecanethiol, or hexadecethiol; the aliphatic amine is selected from one or more of octylamine, octanediamine, or hexadecethiol.
[0016] Furthermore, the organic solvent is selected from one or more of cyclohexane, n-hexane, n-octane, dodecane, tetradecane, liquid paraffin, and kerosene.
[0017] Furthermore, in step one, the volume ratio of aliphatic amine to organic solvent is 1:1 to 10; the volume ratio of alkyl thiol to aliphatic amine is 1:1 to 10; the molar ratio of selenium source to alkyl thiol is 1:1 to 100; and the molar ratio of gold source, silver source to selenium source is 1:0.5 to 2:0.5 to 20.
[0018] Furthermore, in step two, the reaction temperature is 0℃~25℃, and the stirring time is 1~25 minutes.
[0019] Compared with the prior art, the advantages of the present invention are as follows:
[0020] (1) The present invention uses a one-step method to synthesize near-infrared AgAuSe quantum dots, which does not require complex multi-step reactions, is simple to operate, and consumes little energy; the method does not require the use of toxic phosphine-containing reagents, thus avoiding environmental pollution and health risks, and has high reproducibility, making it suitable for large-scale mass production;
[0021] (2) The near-infrared AgAuSe quantum dot material synthesized by this method exhibits excellent stability. After being exposed to air for six months, the morphology and crystal structure of the quantum dots showed no significant changes. At 1 W / cm², the stability was achieved. 2 Nine hours after irradiation with an 808 nm laser at a high power density, the fluorescence intensity of the quantum dots showed no significant change. This characteristic lays the foundation for their commercialization.
[0022] (3) The absolute fluorescence quantum yield of the near-infrared AgAuSe quantum dot material synthesized by this method can exceed 90%. This characteristic makes it promising for applications in solar cells, drug delivery, lighting systems, bioimaging and gas sensing. Attached Figure Description
[0023] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the accompanying drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. In all the drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, the elements or parts are not necessarily drawn to scale.
[0024] Figure 1 The X-ray diffraction pattern of the semiconductor quantum dot material prepared in Example 1;
[0025] Figure 2 A transmission electron microscope image of the semiconductor quantum dot material prepared in Example 1;
[0026] Figure 3 This is a particle size distribution diagram of the semiconductor quantum dot fluorescent material prepared in Example 1;
[0027] Figure 4 The fluorescence emission spectrum of the semiconductor quantum dot fluorescent material prepared in Example 1 is shown.
[0028] Figure 5 The absolute fluorescence quantum yield test spectrum of the semiconductor quantum dot fluorescent material prepared in Example 1 is shown.
[0029] Figure 6 The image shows the thermal stability test spectrum of the semiconductor quantum dot fluorescent material prepared in Example 1.
[0030] Figure 7 The image shows the photostability test spectrum of the semiconductor quantum dot fluorescent material prepared in Example 1.
[0031] Figure 8 This is a biocompatibility test diagram of the semiconductor quantum dot fluorescent material prepared in Example 1;
[0032] Figure 9 This is a transmission electron microscope image of the semiconductor quantum dot material prepared in Example 2;
[0033] Figure 10 This is a particle size distribution diagram of the semiconductor quantum dot fluorescent material prepared in Example 2;
[0034] Figure 11 The fluorescence emission spectrum of the semiconductor quantum dot fluorescent material prepared in Example 2 is shown below.
[0035] Figure 12 Transmission electron microscope images of the semiconductor quantum dot material prepared in Example 3;
[0036] Figure 13 This is a particle size distribution diagram of the semiconductor quantum dot fluorescent material prepared in Example 3;
[0037] Figure 14 The fluorescence emission spectrum of the semiconductor quantum dot fluorescent material prepared in Example 3 is shown.
[0038] Figure 15 Transmission electron microscope image of the semiconductor quantum dot material prepared in Example 4;
[0039] Figure 16 This is a particle size distribution diagram of the semiconductor quantum dot fluorescent material prepared in Example 4;
[0040] Figure 17 The fluorescence emission spectrum of the semiconductor quantum dot fluorescent material prepared in Example 4 is shown.
[0041] Figure 18 A transmission electron microscope image of the semiconductor quantum dot material prepared in Example 5;
[0042] Figure 19 This is a particle size distribution diagram of the semiconductor quantum dot fluorescent material prepared in Example 5;
[0043] Figure 20 The fluorescence emission spectrum of the semiconductor quantum dot fluorescent material prepared in Example 5;
[0044] Figure 21 Photographs of a series of semiconductor quantum dot fluorescent materials prepared on a scaled-up synthesis scale in Example 6 under fluorescent light;
[0045] Figure 22 Near-infrared fluorescence images of a series of semiconductor quantum dot fluorescent materials prepared on a scaled-up basis in Example 6;
[0046] Figure 23 A comparison of fluorescence quantum yield and fluorescence emission wavelength of a series of semiconductor quantum dot fluorescent materials prepared on a scaled-up scale in Example 6;
[0047] Figure 24 A transmission electron microscope image of the semiconductor quantum dot material prepared in Example 7;
[0048] Figure 25 This is a particle size distribution diagram of the semiconductor quantum dot fluorescent material prepared in Example 7;
[0049] Figure 26 The fluorescence emission spectrum of the semiconductor quantum dot fluorescent material prepared in Example 7;
[0050] Figure 27 A schematic diagram of fluorescence testing of the quantum dots prepared in Comparative Example 1;
[0051] Figure 28 This is a schematic diagram of the yield test for the quantum dots prepared in Comparative Example 1. Detailed Implementation
[0052] To clearly and completely describe the technical solution and its specific working process of the present invention, the specific embodiments of the present invention are as follows, in conjunction with the accompanying drawings:
[0053] Example 1
[0054] 207.0 mg of silver acetylacetonate (1 mmol) was weighed and placed in a mixed solution of 2 mL hexadecylamine and 18 mL cyclohexane, and stirred to disperse to obtain an Ag precursor solution. 64.5 mg of selenite (0.5 mmol) was weighed and placed in a mixed solution of 5 mL octylthiol and 5 mL tetradecylamine, and stirred to dissolve to obtain a Se precursor solution. 218.3 mg of gold bromide (0.5 mmol) was weighed and added to 10 mL tetradecene, and stirred to disperse to obtain an Au precursor solution. The Se and Au precursors were then directly added to the Ag precursor solution, and stirred at room temperature (25°C) for 1 minute to obtain AgAuSe quantum dots.
[0055] from Figure 1 As can be seen, the obtained quantum dots are cubic crystals, and the peak positions of their X-ray diffraction patterns are completely consistent with those of the standard sample, indicating the successful preparation of AgAuSe quantum dot materials.
[0056] from Figure 2 as well as Figure 3 As can be seen, the obtained quantum dot material is spherical, has good monodispersity, and has an average size of 2.4 nm.
[0057] from Figure 4 As can be seen, the emission peak of the obtained quantum dot material is at 830 nm.
[0058] from Figure 5 As can be seen, the fluorescence quantum yield of the obtained quantum dots is 98%, indicating that this new synthesis method can prepare quantum dot materials with high luminescence performance.
[0059] from Figure 6 As can be seen, after the quantum dot material is heated from room temperature (25℃) to 100℃ and then cooled back to room temperature, after 8 cycles, its fluorescence intensity does not decrease significantly, indicating that the quantum dot has good thermal stability.
[0060] from Figure 7 As can be seen, exposing quantum dots to 1 W / cm 2 After 9 hours under an 808 nm laser at a power density, the fluorescence intensity of the quantum dot showed no significant decay, indicating that the quantum dot has good photostability.
[0061] from Figure 8 As can be seen, when different concentrations of quantum dots after conversion to aqueous phase were cultured with 4T1 cells or Raw 264.7 cells, the cell viability did not decrease significantly, indicating that AgAuSe quantum dots have good biocompatibility and can be further applied in the fields of bioimaging and biosensing.
[0062] Example 2
[0063] 196.9 mg of silver lactate (1 mmol) was weighed and placed in a mixed solution of 2 mL octylamine and 18 mL n-hexane, and stirred to disperse to obtain an Ag precursor solution. 30.8 mg of selenourea (0.25 mmol) was weighed and placed in a mixed solution of 5 mL decanethiol and 5 mL octylamine, and stirred to dissolve to obtain a Se precursor solution. 188.9 mg of potassium chloroaurate (0.5 mmol) was weighed and added to 10 mL dodecane, and stirred to dissolve to obtain an Au precursor solution. The Se and Au precursors were then directly added to the Ag precursor solution, and the mixture was stirred at 0°C for 25 minutes to obtain AgAuSe quantum dots.
[0064] from Figure 9 and Figure 10 As can be seen, the obtained quantum dot material is spherical, has good monodispersity, and has an average size of 2.9 nm.
[0065] from Figure 11 As can be seen, the emission peak of the obtained quantum dot material is at 900 nm.
[0066] Example 3
[0067] 25.7 mg of silver trifluoromethanesulfonate (0.1 mmol) was weighed and placed in a mixed solution of 1 mL hexadecylamine and 9 mL liquid paraffin, and stirred to disperse to obtain an Ag precursor solution. 10.3 mg of potassium selenite (0.05 mmol) was weighed and placed in a mixed solution of 1 mL tetradecyl mercaptan and 1 mL octanediamine, and stirred to dissolve to obtain a Se precursor solution. 37.4 mg of gold acetate (0.1 mmol) was weighed and added to 5 mL kerosene, and stirred to dissolve to obtain an Au precursor solution. The Se and Au precursors were directly added to the Ag precursor, and the mixture was stirred at 10 °C for 20 minutes to obtain AgAuSe quantum dots.
[0068] from Figure 12 and Figure 13 As can be seen, the obtained quantum dot material is spherical, has good monodispersity, and has an average size of 3.2 nm.
[0069] from Figure 14 As can be seen, the emission peak of the obtained quantum dot material is at 925 nm.
[0070] Example 4
[0071] 102.5 mg of silver citrate (0.2 mmol) was weighed and placed in a mixed solution of 5 mL hexadecylamine and 45 mL kerosene, and stirred to disperse to obtain an Ag precursor solution. 15.1 mg of N,N-dimethylselenourea (0.1 mmol) was weighed and placed in a mixed solution of 2 mL tetradecyl mercaptan and 2 mL hexadecylamine, and stirred to dissolve to obtain a Se precursor solution. 57.8 mg of gold iodide (0.1 mmol) was weighed and added to 5 mL of n-octane, and stirred to disperse to obtain an Au precursor solution. The Se and Au precursors were directly added to the Ag precursor, and the mixture was stirred at room temperature (25 °C) for 10 minutes to obtain AgAuSe quantum dots.
[0072] from Figure 15 and Figure 16 As can be seen, the obtained quantum dot material is spherical, has good monodispersity, and has an average size of 3.3 nm.
[0073] from Figure 17 As can be seen, the emission peak of the obtained quantum dot material is at 980 nm.
[0074] Example 5
[0075] 391.3 mg of silver stearate (1 mmol) was weighed and placed in a mixed solution of 5 mL octylamine and 5 mL n-octane, and stirred to disperse to obtain an Ag precursor solution. 123.0 mg of selenourea (1 mmol) was weighed and placed in a mixed solution of 5 mL decanethiol and 5 mL hexadecylamine, and stirred to dissolve to obtain a Se precursor solution. 188.9 mg of potassium chloroaurate (0.5 mmol) was weighed and added to 10 mL dodecane, and stirred to dissolve to obtain an Au precursor solution. The Se and Au precursors were then directly added to the Ag precursor solution, and the mixture was stirred at 0°C for 25 minutes to obtain AgAuSe quantum dots.
[0076] from Figure 18 and Figure 19 As can be seen, the obtained quantum dot material is spherical, has good monodispersity, and has an average size of 3.8 nm.
[0077] from Figure 20 As can be seen, the emission peak is located at 1130 nm.
[0078] Example 6
[0079] The experiment to scale up quantum dot preparation is shown in this example. 3.91 g of silver stearate (10 mmol) was weighed and placed in a mixed solution of 50 mL hexadecanine and 450 mL n-hexane, and dispersed by stirring to obtain an Ag precursor solution. 4.42 g of potassium selenate (20 mmol) was weighed and placed in a mixed solution of 20 mL tetradecyl mercaptan and 20 mL octylamine, and dissolved by stirring to obtain a Se precursor solution. 2.89 g of gold iodide (5 mmol) was weighed and added to 50 mL cyclohexane, and dispersed by stirring to obtain an Au precursor solution. The Se and Au precursors were then directly added to the Ag precursor, and the mixture was stirred at room temperature (25°C) for 25 minutes to obtain AgAuSe quantum dots.
[0080] from Figure 21 and Figure 22 As can be seen, quantum dot materials synthesized at different scales can emit strong near-infrared light when excited by ultraviolet lamps and in near-infrared cameras.
[0081] from Figure 23 As can be seen, the fluorescence quantum yield of quantum dot materials obtained by different synthesis scales can be maintained above 90%, and the emission peak position can be maintained at around 935 nm. The luminescence performance does not change significantly, indicating that the synthesis method can realize the large-scale preparation of AgAuSe quantum dots with high near-infrared fluorescence emission capability and has good reproducibility.
[0082] Example 7
[0083] 10.8 mg of silver quantum dots were weighed and placed in a mixed solution of 0.1 mL hexadecylamine and 5 mL n-hexane, and stirred to disperse to obtain an Ag precursor solution. 7.9 mg of selenium quantum dots were weighed and placed in a mixed solution of 1 mL octanedithiol and 1 mL octylamine, and stirred to dissolve to obtain a Se precursor solution. 19.7 mg of gold quantum dots were weighed and added to 10 mL n-hexane, and stirred to dissolve to obtain an Au precursor solution. The Se and Au precursors were then directly added to the Ag precursor solution, and the mixture was stirred at 10°C for 20 minutes to obtain AgAuSe quantum dots.
[0084] from Figure 24 and Figure 25 As can be seen, the obtained quantum dot material is spherical, has good monodispersity, and has an average size of 4.1 nm.
[0085] from Figure 26 As can be seen, the emission peak is located at 1280 nm.
[0086] from Figure 4 , Figure 11 , Figure 17 and Figure 26 It can be seen that by simply changing the type of precursor, the feed ratio, and the reaction temperature, the particle size of the product can be adjusted relatively easily, thereby regulating its emission wavelength range.
[0087] Comparative Example 1
[0088] This comparative example provides a method for preparing silver selenide quantum dots, including the following steps:
[0089] Raw material preparation: (1) Add selenium powder to organophosphorus solution and stir and mix evenly under light-protected conditions to obtain selenium-organophosphorus solution; (2) Mix octadecene, thiol and silver acetate, and heat to 160°C in an inert gas for 30 min to obtain a clear reaction solution; (3) Add the selenium-organophosphorus solution in step (1) to the reaction solution in step (2) and mix evenly, and heat to 160°C in an inert atmosphere for 1 h to obtain the silver selenide quantum dots.
[0090] The emission wavelength of the silver selenide quantum dots prepared in this comparative example is similar to that of the AgAuSe quantum dots in the examples. The specific difference is that Au was added as a passivating agent for the silver selenide quantum dots in Example 1, while Au passivation treatment was not used in Comparative Example 1.
[0091] The quantum dots prepared in the above comparative examples were subjected to fluorescence and fluorescence quantum yield tests, such as... Figure 27 As shown, the silver selenide synthesized by the comparative method exhibits extremely weak fluorescence intensity, such as... Figure 28As shown, its emission peak is located at 850 nm, and the fluorescence quantum yield is 4.7%. The fluorescence intensity and quantum efficiency of the quantum dots synthesized by this comparative method are significantly lower than those synthesized in Example 1. This is because the original silver selenide quantum dots have too many surface defects, while the addition of Au can effectively passivate the defects of the quantum dots, thereby improving their luminescence performance.
[0092] Comparative Example 2
[0093] This comparative example provides a method for preparing silver-gold-selenium quantum dots, including the following steps:
[0094] 0.06 g of silver nitrate was dissolved in 20 mL of oleylamine and ultrasonically dispersed. Then, 0.06 g of selenium powder was added, and the mixture was reacted at 200 °C for 5 h. The crude product was washed and purified to obtain the silver selenide quantum dot precursor. Next, 0.06 g of chloroauric acid was added to the silver selenide quantum dot precursor, and the mixture was reacted at 100 °C for 48 h to obtain silver-gold-selenium quantum dots.
[0095] The AgAuSe quantum dots prepared in this comparative example have a similar structure to those in the examples. The specific differences are as follows: Example 1 uses a thiol-fatty amine mixed liquid as a co-solvent for the selenium source, which has higher activity and can adapt to the reactivity of both Ag and Au precursors. This allows for rapid, large-scale preparation of AgAuSe quantum dots at room temperature. Furthermore, Example 1 eliminates the need for separate and purified Ag2Se quantum dots, directly synthesizing AgAuSe quantum dots in a one-step process. In contrast, Comparative Example 2 uses a traditional high-temperature solvothermal method to first synthesize Ag2Se quantum dots separately. This method requires higher temperatures and longer reaction times, and necessitates washing before the next cation exchange reaction, making it a two-step process. Compared to Example 1, this process is more cumbersome and limits the further application of this material.
[0096] The preferred embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the specific details of the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.
[0097] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not describe the various possible combinations separately.
[0098] Furthermore, various different embodiments of the present invention can be combined in any way, as long as they do not violate the spirit of the present invention, they should also be regarded as the content disclosed by the present invention.
Claims
1. A method for room-temperature macro-scale preparation of near-infrared light-emitting AgAuSe quantum dots, characterized in that, Specifically comprising the following steps: Step one: preparing a precursor solution; adding a silver source into a mixed solution of aliphatic amine and organic solvent, stirring and dispersing to obtain a silver precursor solution; dissolving a selenium source in a mixed solution of aliphatic amine and alkyl mercaptan to obtain a selenium precursor solution; dispersing a gold source in an organic solvent to obtain a gold precursor solution; Step two: synthesizing quantum dots; mixing the silver precursor solution, the selenium precursor solution and the gold precursor solution, stirring and reacting at room temperature, and removing insoluble precipitates by centrifugation to obtain near-infrared luminescent AgAuSe quantum dots.
2. The method of claim 1, wherein the method is a room-temperature macro- scale preparation method of near-infrared light-emitting AgAuSe quantum dots. The silver source is selected from one or more of silver trifluoromethanesulfonate, silver acetylacetonate, silver lactate, silver citrate, silver stearate or silver quantum dots; the selenium source is selected from one or more of selenious acid, potassium selenite, zinc selenite, potassium selenate, selenourea, N,N-dimethyl selenourea or selenium quantum dots; and the gold source is selected from one or more of potassium chloroaurate, ammonium chloroaurate, gold acetate, gold bromide, gold iodide, gold clusters or gold quantum dots.
3. The method of claim 1, wherein the method is characterized by, The alkyl mercaptan is selected from one or more of octanedithiol, decanethiol, tetradecanethiol or hexadecanethiol; and the aliphatic amine is selected from one or more of octylamine, octanediamine or hexadecylamine.
4. The method of claim 1, wherein the method is characterized by, The organic solvent is selected from one or more of cyclohexane, n-hexane, n-octane, dodecane, tetradecane, liquid paraffin and kerosene.
5. The method of claim 1, wherein the method is a room-temperature macro- scale preparation method of near-infrared light-emitting AgAuSe quantum dots. In step one, the volume ratio of aliphatic amine to organic solvent is 1:1-10; the volume ratio of alkyl mercaptan to aliphatic amine is 1:1-10; the molar ratio of selenium source to alkyl mercaptan is 1:1-100; and the molar ratio of gold source, silver source to selenium source is 1:0.5-2:0.5-20.
6. The method of claim 1, wherein the method is a room-temperature macro- scale preparation method of near-infrared light-emitting AgAuSe quantum dots. In step two, the reaction temperature is 0-25℃, and the stirring time is 1-25 minutes.
7. A near-infrared light-emitting AgAuSe quantum dot, characterized in that, Prepared by the method of any one of claims 1-6. Prepared by the method of any one of claims 1-6.