Multifunctional sample digestion treatment platform

Abstract

The invention relates to the technical field of automatic control of analytical chemical instruments, in particular to a multifunctional sample digestion treatment platform. The constant-pressure liquid storage unit and the dynamic pressure balance unit of the liquid adding unit are controlled through fluid to optimally execute liquid adding treatment, then a liquid storage constant-pressure instruction is output, the reagent liquid storage pressure is stabilized, the problem of low trace adding precision caused by pressure fluctuation when a strong corrosive reagent is conveyed is solved, the reagent adding error is reduced, and the reagent adding efficiency is improved. The liquid adding precision and stability are improved; the dynamic pressure balance unit is used for carrying out pressure balance analysis on the reagent conveying line to obtain an infusion constant-pressure instruction and executing the instruction, the deviation degree of each conveying section is calculated, pressure abnormity can be recognized and adjusted in a targeted mode, the problems of valve body sealing aging and reagent steam corrosion precision elements are solved, the sealing performance of the conveying line is guaranteed, and the service life of the conveying line is prolonged. And the overall reliability of the platform is improved.

Description

Technical Field

[0001] This invention relates to the field of automated control technology for analytical chemistry instruments, specifically a multifunctional sample digestion and processing platform. Background Technology

[0002] Sample digestion is a crucial pretreatment step in environmental and occupational health monitoring. It requires handling various sample types, including gases, metals, food, and soil, and performing operations such as synergistic reactions of toxic and hazardous reagents and impurity separation. The core of the processing platform includes sample barcode identification, crushing pretreatment, automatic addition and reflux of multiple reagents, filtration and volume adjustment post-treatment, and a fully automated control module. This breakthrough in full-process automation not only significantly improves the standardization and efficiency of sample processing but also reduces safety risks and cross-contamination by minimizing human intervention, providing a reliable prerequisite for accurate detection. Currently, the automatic liquid addition system of the multi-functional sample digestion platform suffers from problems such as easy aging of valve sealing materials, low precision in micro-dosing, and corrosion of precision components by reagent vapor when delivering highly corrosive reagents such as concentrated nitric acid and hydrofluoric acid. Summary of the Invention

[0003] This invention provides a multifunctional sample digestion and processing platform to solve the above-mentioned technical problems.

[0004] The first aspect of the present invention provides a multifunctional sample digestion and processing platform, including a sample identification and pretreatment module, a multi-reagent automatic liquid addition module, and a master control and interaction module.

[0005] The sample identification and preprocessing module is used to identify and preprocess samples to obtain basic sample information. Specifically, it identifies each sample based on a preset sample identification technology to obtain the sample type and sample mode, which includes gaseous, liquid, and solid samples. When the sample mode corresponds to a solid sample, the corresponding sample is crushed to obtain a processed sample. The processed sample and all other samples are marked as pre-samples. Each pre-sample is matched with a sample process library stored in the database to obtain the corresponding preset digestion process parameters. The preset digestion process parameters and the corresponding sample type of each pre-sample are packaged together to obtain the basic sample information.

[0006] The multi-reagent automatic liquid addition module uses a preset reagent delivery line to add reagents stored in a preset reagent storage unit to each pre-sample to obtain a liquid-added sample, and optimizes the liquid addition process by using a preset fluid control liquid addition unit.

[0007] The fluid control liquid dosing unit includes a constant pressure liquid storage unit and a dynamic pressure balancing unit, which are used for the optimized execution of liquid dosing treatment;

[0008] The constant pressure storage unit is used to perform constant pressure compensation analysis on the reagent storage unit to obtain the constant pressure command for the storage liquid, and then execute the command.

[0009] As a further improvement of the present invention, constant pressure compensation analysis is performed on the reagent storage unit to obtain a constant pressure command for the storage liquid. The specific analysis steps are as follows:

[0010] Based on the preset constant pressure analysis time interval, the constant pressure analysis time point is obtained, and data is collected from the reagent storage unit to obtain storage pressure data, liquid level data and storage temperature data;

[0011] The system analyzes the liquid pressure data, liquid level data, and liquid temperature data to output the baseline coupling value, dynamic interference value, and feedback correction value.

[0012] The benchmark coupling value, dynamic disturbance value, and feedback correction value corresponding to the current constant pressure analysis time point are substituted into the preset coupling compensation formula to calculate and output the final compensation pressure value.

[0013] The final compensation pressure value at the current constant pressure analysis time point is used as the pressure adjustment target value, and the output liquid storage constant pressure command is to adjust the real-time liquid storage pressure value to the pressure adjustment target value.

[0014] Furthermore, the system analyzes and outputs baseline coupling values, dynamic interference values, and feedback correction values ​​based on the liquid pressure data, liquid level data, and liquid temperature data. The specific execution steps are as follows: obtain the real-time liquid temperature at the current constant pressure analysis time point based on the liquid temperature data; obtain the preset reference pressure, standard temperature, reference viscosity, and reagent viscosity reference values ​​for each reagent based on the database; and calculate and output the baseline coupling value using the preset baseline coupling calculation formula.

[0015] The real-time liquid temperature and standard viscosity are input into a preset real-time reagent viscosity calculation formula to calculate the reagent viscosity at the real-time temperature; the real-time liquid level is obtained based on the liquid level data, and the liquid level at the previous constant pressure analysis time point is obtained. The difference between the real-time liquid level and the liquid level at the previous constant pressure analysis time point is calculated and marked as the liquid level change value. The ratio of the liquid level change value to the duration of the constant pressure analysis time interval is calculated to obtain the liquid level change rate; the real-time liquid level, reference density, reagent viscosity at the real-time temperature, and liquid level change rate are substituted into a preset dynamic interference calculation formula to calculate the dynamic interference value.

[0016] Historical pressure compensation data is extracted from the database. Multiple historical pressure compensation values ​​and corresponding historical measured pressure values ​​(i.e., real-time storage pressure values ​​at historical constant pressure analysis time points corresponding to each historical pressure compensation value) are obtained from this data. The pressure difference is calculated by subtracting the historical pressure compensation values ​​from the historical measured pressure values, and the absolute value of the pressure difference is recorded as the compensation error value. Real-time storage pressure values ​​are obtained based on the storage pressure data at the current constant pressure analysis time point. The real-time storage pressure value is calculated by subtracting the real-time storage pressure value from the benchmark coupling value. A feedback correction value is then calculated and output using a preset feedback correction calculation formula to evaluate the compensation error value and the real-time pressure deviation.

[0017] The dynamic pressure balancing unit is used to perform pressure balancing analysis on the reagent delivery line to obtain constant infusion pressure commands and execute the commands.

[0018] As a further improvement of the present invention, a pressure balance analysis is performed on the reagent delivery line to obtain a constant infusion pressure command, and the specific execution steps are as follows:

[0019] Obtain the pre-deployed valve control adjustment groups for each reagent delivery line, and divide each reagent delivery line into multiple delivery segments based on the valve control adjustment groups. The delivery segments include an upstream delivery segment, a valve control adjustment segment, and a downstream buffer segment.

[0020] The parameters of the upstream conveying section, the valve-controlled regulation section, and the downstream buffer section are collected by pre-deployed sensors. The upstream conveying section parameters include upstream conveying pressure, upstream conveying flow rate, and reagent temperature. The valve-controlled regulation section parameters include the pressure before the valve core, the pressure after the valve core, the reagent viscosity in the valve-controlled section, and the valve-controlled drive voltage. The downstream buffer section parameters include the end pressure of the downstream buffer section and the fluid pressure pulsation frequency.

[0021] The upstream deviation is obtained by analyzing the parameters of the upstream conveying section; the valve control deviation is obtained by analyzing the parameters of the valve control regulating section; the downstream deviation is obtained by analyzing the parameters of the downstream buffer section; and the line pressure deviation is obtained by comprehensively calculating the upstream deviation, valve control deviation, and downstream deviation.

[0022] The line pressure deviation is obtained by comprehensively calculating the upstream deviation, valve control deviation, and downstream deviation. Specifically, the upstream deviation, valve control deviation, and downstream deviation are normalized and their values ​​are taken. The line pressure deviation is then calculated and output using a preset comprehensive pressure deviation calculation formula.

[0023] The infusion constant pressure command is output by analyzing the pressure deviation of the line. Specifically, based on a preset deviation threshold, the pressure deviation of the line is divided into three pressure deviation intervals. These three intervals are arranged in ascending order and labeled as Level 1, Level 2, and Level 3 deviation intervals, respectively. When the pressure deviation of the reagent delivery line is in the Level 1 deviation interval, the line status is generated as stable pressure, and no infusion constant pressure command is issued. When it is in the Level 2 deviation interval, the line status is generated as pressure deviation, and the infusion constant pressure command is adjusted by the valve control adjustment group. When it is in the Level 3 deviation interval, the line status is generated as abnormal pressure deviation, and the infusion constant pressure command is for emergency control.

[0024] Furthermore, the upstream deviation is obtained by analyzing the parameters of the upstream conveying section. Specifically, the upstream conveying section parameters are identified to obtain the upstream conveying pressure, upstream conveying flow rate, and reagent temperature; the upstream inlet pressure and upstream outlet pressure are obtained based on the upstream conveying pressure; the difference between the upstream inlet pressure and the upstream outlet pressure is calculated and marked as the upstream pressure change; the values ​​of the upstream pressure change, upstream conveying flow rate, and reagent temperature are input into a preset upstream deviation calculation formula to calculate and output the upstream deviation.

[0025] Furthermore, the valve control deviation is obtained by analyzing the parameters of the valve control adjustment section. Specifically, this involves identifying the parameters of the valve control adjustment section to obtain the pressure before the valve core, the pressure after the valve core, the reagent viscosity of the valve control section, and the valve control driving voltage; and inputting the values ​​of each valve control adjustment section parameter into a preset valve control section deviation calculation formula. Calculate the output valve control deviation. ;in, These are the pressure before the valve core and the pressure after the valve core, respectively. These are the reagent viscosity and valve-controlled drive voltage in the valve-controlled section, respectively. This is the rated drive voltage; Rated pressure drop designed for valve-controlled regulating sections.

[0026] Furthermore, the downstream deviation is obtained by analyzing the parameters of the downstream buffer section. Specifically, the downstream deviation is calculated by obtaining the terminal pressure and fluid pressure pulsation frequency of the downstream buffer section based on the downstream buffer section parameters, and then using a preset downstream deviation calculation formula. The downstream deviation is output by calculating the values ​​of the terminal pressure and the fluid pressure pulsation frequency. ;in, These are the terminal pressure and fluid pressure pulsation frequencies, respectively. Set a target pressure for the end of the database; This is the fluid pulsation correction factor; The rated pressure drop is preset for the downstream buffer section.

[0027] The overall control interaction module includes a digestion treatment evaluation unit and a visualization unit. The digestion treatment evaluation unit evaluates the sample after liquid addition, outputs a sample digestion treatment report, and sends it to the visualization unit for report display.

[0028] The beneficial effects of the technical solution provided by this invention compared with the prior art are as follows:

[0029] 1. This invention optimizes the liquid addition process by using the constant pressure storage unit and dynamic pressure balancing unit of the fluid control liquid addition unit, and then outputs a constant pressure command for the storage liquid to stabilize the pressure of the reagent storage liquid. This solves the problem of low accuracy in micro-dosing caused by pressure fluctuations during the delivery of highly corrosive reagents, reduces reagent addition errors, and improves the accuracy and stability of liquid addition.

[0030] 2. This invention uses a dynamic pressure balancing unit to perform pressure balancing analysis on the reagent delivery line to obtain and execute the constant pressure command for infusion, calculate the deviation of each delivery section, identify pressure anomalies and make targeted adjustments, solve the problems of valve body seal aging and reagent vapor corrosion of precision components, ensure the sealing of the delivery line, and improve the overall reliability of the platform. Attached Figure Description

[0031] To more clearly illustrate the technical solutions of the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. The following drawings are not deliberately drawn to scale according to the actual size, but are intended to show the main idea of ​​this application.

[0032] Figure 1 This is a schematic diagram of the principle of the multifunctional sample digestion and processing platform of the present invention;

[0033] Figure 2 This is a flowchart of the constant pressure liquid storage unit of the present invention;

[0034] Figure 3 This is a flowchart of the dynamic pressure balancing unit of the present invention. Detailed Implementation

[0035] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0036] For ease of understanding, the specific process of the embodiments of the present invention is described below. Please refer to [link / reference]. Figure 1-3 In one embodiment of the present invention, the multifunctional sample digestion processing platform includes:

[0037] The sample identification and preprocessing module identifies and preprocesses samples to obtain basic sample information. Specifically, it identifies each sample based on a preset sample identification technology to obtain the corresponding sample type and sample modality. Sample types include gaseous metals, food, and soil, and sample modalities include gaseous, liquid, and solid samples. When the sample modality corresponds to a solid sample, the corresponding sample is crushed to obtain a processed sample. The processed sample and all other samples are marked as pre-samples. Each pre-sample is matched with a pre-stored sample process library in the database to obtain the corresponding preset digestion process parameters, including but not limited to reagent type, target dosage, reaction temperature, and reflux time. The preset digestion process parameters and corresponding sample types of each pre-sample are packaged together to obtain the basic sample information.

[0038] The multi-reagent automatic liquid addition module uses a preset reagent delivery line to add reagents stored in a preset reagent storage unit to each pre-sample to obtain a liquid-added sample, and optimizes the liquid addition process by using a preset fluid control liquid addition unit.

[0039] The fluid control liquid dosing unit includes a constant pressure liquid storage unit and a dynamic pressure balancing unit, which are used for the optimized execution of liquid dosing.

[0040] The constant pressure storage unit performs constant pressure compensation analysis on the reagent storage unit to obtain the storage constant pressure command, and then executes the command.

[0041] The constant pressure compensation analysis of the reagent storage unit was performed, and the specific analysis content is as follows:

[0042] A1. Constant pressure analysis data acquisition: Based on the preset constant pressure analysis time interval, the constant pressure analysis time point is obtained, and data acquisition is performed on the reagent storage unit to obtain storage pressure data, liquid level data and storage temperature data;

[0043] A2. Calculation of Reference Coupling Value: The real-time storage temperature at the current constant pressure analysis time point is obtained based on the storage temperature data; the preset reference pressure (a process test calibration value obtained through sample experiment fitting, e.g., hydrofluoric acid 0.2 MPa, concentrated nitric acid 0.18 MPa), reference viscosity at standard temperature (the standard temperature is a preset temperature, e.g., the viscosity corresponding to the reagent at a standard temperature of 25℃ is the reference viscosity), and reagent viscosity reference values ​​(standard values ​​set by various reagent industries) are obtained from the database; the reference coupling value is calculated and output using the preset reference coupling calculation formula, i.e., through the formula... Calculate and output the reference coupling value ;in, These are the reference values ​​for the adaptation reference pressure, real-time storage temperature, standard temperature, reference viscosity, and reagent viscosity, respectively. This is a temperature correction factor used to adapt to the temperature sensitivity of different reagents. ,in, This is the actual reference density at standard temperature; This is the correction factor for the reference viscosity deviation, i.e. It should be noted that all the index data involved in the above calculations have undergone data preprocessing to eliminate the influence of dimensions. The specific methods for eliminating the influence of dimensions are well-known to those skilled in the art and are not limited here. The calculation results are ultimately assigned to the target unit (MPa). The core of this formula is to add correction terms for temperature and viscosity deviations to the reagent-adapted reference pressure to obtain a reference coupling pressure that closely matches the real-time reagent state. Quantify the deviation between the real-time and standard temperatures, multiply by The subsequent reflection shows the effect of temperature fluctuations on pressure; The deviation between the quantified standard and the reference viscosity, multiplied by The effect of post-corrected viscosity characteristics on pressure.

[0044] A3. Dynamic Interference Calculation: The real-time storage temperature and standard viscosity are input into a preset real-time reagent viscosity calculation formula to calculate the reagent viscosity at the real-time temperature. The viscosity of the reagent at the real-time temperature was calculated. The effect of temperature on viscosity is characterized by a combination of linear and quadratic terms: linear term Quantifying the linear effect of temperature deviation on viscosity (viscosity decreases with increasing temperature), quadratic term To compensate for nonlinear effects, the exponential function converts the combined value of temperature deviations into a viscosity change factor, which aligns with the physical law of reagent viscosity changing with temperature.

[0045] The real-time liquid level height (vertical distance from the reagent page to the liquid dispensing outlet) is obtained based on the liquid level data. The liquid level height at the previous constant pressure analysis time point is obtained. The difference between the real-time liquid level height and the liquid level height at the previous constant pressure analysis time point is calculated and marked as the liquid level change value. The liquid level change value is calculated as the ratio of the liquid level change value to the duration of the constant pressure analysis time interval to obtain the liquid level height change rate.

[0046] Substitute the real-time liquid level, reference density, reagent viscosity at real-time temperature, and rate of change of liquid level into the preset dynamic disturbance calculation formula. The dynamic interference value is calculated. ;in, These are the real-time liquid level height and the rate of change of liquid level height, respectively. The preset density temperature correction factor has a value of [value missing]. The hyperbolic tangent function is used to achieve nonlinear control of temperature on the correction coefficient; The preset coupling coefficient between consumption rate and viscosity is set to a value of [value missing]. This coefficient, after being scaled to fit the reference pressure, quantifies the influence of pressure characteristics on the consumption rate-viscosity coupling effect; g represents gravitational acceleration; it should be noted that all index data involved in the above calculations have undergone data preprocessing to eliminate the influence of dimensions. The specific methods for eliminating the influence of dimensions are well-known to those skilled in the art and are not limited here, and the calculation results are ultimately assigned to the target unit (MPa).

[0047] A4. Feedback Correction Calculation: Based on historical data in the database, historical pressure compensation data is extracted. Multiple historical pressure compensation values ​​and corresponding historical measured pressure values ​​are obtained from the historical pressure compensation data. That is, the real-time storage pressure value of the storage pressure data at the historical constant pressure analysis time point corresponding to each historical pressure compensation value. The pressure difference is calculated by the difference between the historical pressure compensation value and the historical measured pressure value. The absolute value of the pressure difference is taken and recorded as the compensation error value.

[0048] The real-time storage pressure value is obtained based on the storage pressure data at the current constant pressure analysis time point. The difference between the real-time storage pressure value and the benchmark coupling value is calculated to obtain the real-time pressure deviation value. A preset feedback correction calculation formula is used to calculate the compensation error value and the real-time pressure deviation, outputting a feedback correction value. The feedback correction value is obtained through calculation. ;in, is the compensation error value corresponding to the (i-1)th historical pressure compensation value, and N is the total number of historical pressure compensation values; This is expressed as the real-time pressure deviation value at the current constant pressure analysis time point t. This is expressed as the rate of change of real-time pressure deviation. This represents the total duration corresponding to the constant pressure analysis time points t, t-1, and t-2. Represented as error weighting coefficients; This is expressed as the deviation change rate correction coefficient. It should be noted that during the calculation of the above formula, all indicator data involved in the calculation have undergone data preprocessing to eliminate the influence of dimensions, and the final calculation result is assigned to the target unit (MPa). It integrates historical error feedback and real-time deviation change rate: the first part is a weighted average of historical errors (with higher weight for recent errors), quantifying the correction needs of historical compensation experience for current pressure; the second part is the real-time deviation change rate, characterizing the real-time correction magnitude of pressure fluctuations. The two are superimposed to achieve accurate pressure correction based on both historical and real-time data.

[0049] A5. Final pressure compensation calculation output: Substitute the baseline coupling value, dynamic disturbance value, and feedback correction value corresponding to the current constant pressure analysis time point into the preset coupling compensation formula. Calculate and output the final compensation pressure value The first part uses an exponential function to attenuate the impact of dynamic disturbances on the reference coupling value (the greater the disturbance, the higher the amplification of the reference value); the second part uses a hyperbolic tangent function to limit the nonlinear saturation of the feedback correction value, avoiding over-correction; among which, The preset dynamic interference attenuation coefficient is determined based on the adaptive reference pressure and is used to control the influence of the interference value on the compensation value. For example... ; The preset feedback correction threshold, determined based on the adaptive reference pressure, is used to control the nonlinear saturation of the feedback value, for example... .

[0050] A6. Constant pressure command for storage liquid: The final compensation pressure value at the current constant pressure analysis time point is used as the pressure adjustment target value. The output constant pressure command for storage liquid is to adjust the real-time storage liquid pressure value to the pressure adjustment target value.

[0051] The dynamic pressure balancing unit performs pressure balancing analysis on the reagent delivery line to obtain a constant pressure command for infusion and executes the command.

[0052] A pressure balance analysis was performed on the reagent delivery line, and the specific analysis content is as follows:

[0053] S1. Line Pressure Zoning: Obtain the pre-deployed valve control adjustment groups for each reagent delivery line. Based on the valve control adjustment groups, divide the delivery line of each reagent into multiple delivery segments, including the upstream delivery segment (i.e., from the outlet of the storage tank to the inlet of the valve control adjustment group), the valve control adjustment segment (i.e., inside the micro-valve group), and the downstream buffer segment (from the outlet of the valve control adjustment group to the inlet of the next stage). Zoning analysis of pressure deviation and graded control are performed to accurately solve the line pressure imbalance problem and reduce the risk of reagent vapor corrosion and valve body aging.

[0054] S2. Pressure Zone Data Acquisition: Pre-deployed sensors collect data on each delivery section to obtain parameters for the upstream delivery section, valve-controlled regulation section, and downstream buffer section. Upstream delivery section parameters include upstream delivery pressure, upstream delivery flow rate, and reagent temperature. Valve-controlled regulation section parameters include pressure before and after the valve core, reagent viscosity, and valve-controlled drive voltage. Downstream buffer section parameters include the end pressure and fluid pressure pulsation frequency of the downstream buffer section.

[0055] S3. Line pressure balance analysis: Analyze the parameters of the upstream transmission section to obtain the upstream deviation; analyze the parameters of the valve-controlled regulating section to obtain the valve control deviation; analyze the parameters of the downstream buffer section to obtain the downstream deviation; and calculate the line pressure deviation by comprehensively considering the upstream deviation, valve control deviation, and downstream deviation.

[0056] S31: Analyze the upstream conveying section parameters to obtain the upstream deviation, specifically: identify the upstream conveying section parameters to obtain the upstream conveying pressure, upstream conveying flow rate, and reagent temperature; obtain the upstream section inlet pressure and upstream section outlet pressure based on the upstream conveying pressure; calculate the difference between the upstream section inlet pressure and upstream section outlet pressure and mark the difference as the upstream pressure change; input the values ​​of the upstream pressure change, upstream conveying flow rate, and reagent temperature into the preset upstream deviation calculation formula. Calculate and output upstream deviation. ;in, These are the upstream pressure change, upstream delivery flow rate, and reagent temperature, respectively. These are the rated flow rate and rated pressure drop designed for the upstream conveying section, respectively. These are the preset flow correction coefficients and temperature correction coefficients for the upstream conveying section, with values ​​based on pipeline resistance fitting. The upstream deviation calculation formula integrates the effects of flow and temperature deviations on pressure changes through an exponential function: the greater the flow deviation from the rated value, the larger the exponential term, and the amplified pressure change; the greater the temperature deviation from the reference value, the smaller the exponential term, and the smaller the pressure change. Finally, subtracting the rated pressure drop yields the upstream pressure deviation degree, reflecting the degree of pressure anomaly in the upstream conveying section.

[0057] S32: Analyze the parameters of the valve-controlled adjustment section to obtain the valve control deviation. Specifically, identify the parameters of the valve-controlled adjustment section to obtain the pressure before the valve core, the pressure after the valve core, the reagent viscosity of the valve-controlled section, and the valve control driving voltage; and input the values ​​of each valve-controlled adjustment section parameter into the preset valve control section deviation calculation formula. Calculate the output valve control deviation. ;in, These are the pressure before the valve core and the pressure after the valve core, respectively. These are the reagent viscosity and valve-controlled drive voltage in the valve-controlled section, respectively. This is the rated drive voltage; The rated pressure drop is designed for the valve-controlled regulating section. In the valve-controlled section deviation calculation formula, the hyperbolic tangent function characterizes the ratio of the pressure difference across the valve core to the coupling terms of viscosity and drive voltage: the larger the pressure difference, the lower the viscosity, and the closer the drive voltage is to the rated value, the closer the function value is to 1, and the higher the risk of pressure deviation in the valve-controlled section. Subtracting the rated pressure drop yields the valve-controlled deviation degree, accurately reflecting abnormal pressure in the valve-controlled section.

[0058] S33: Analyze the downstream buffer section parameters to obtain the downstream deviation, specifically: obtain the terminal pressure and fluid pressure pulsation frequency of the downstream buffer section based on the downstream buffer section parameters, and calculate the downstream deviation using a preset formula. The downstream deviation is output by calculating the values ​​of the terminal pressure and the fluid pressure pulsation frequency. ;in, These are the terminal pressure and fluid pressure pulsation frequencies, respectively. Set a target pressure for the end of the database; This is a fluid pulsation correction factor, used to quantify the effect of pulsation frequency on pressure deviation, and to avoid pulsation interference being amplified or reduced beyond the limit. The rated pressure drop is preset for the downstream buffer section. The downstream deviation calculation formula is first passed through... The deviation between the terminal pressure and the target value is characterized by a logarithmic term that quantifies the amplification effect of fluid pulsation on the deviation (the higher the pulsation frequency, the greater the amplification of the deviation). To avoid calculation errors caused by pulsation interference, the downstream deviation is obtained after subtracting the rated pressure drop, reflecting the stable pressure state of the downstream buffer section.

[0059] S34: The line pressure deviation is obtained by comprehensively calculating the upstream deviation, valve control deviation, and downstream deviation. Specifically, the upstream deviation, valve control deviation, and downstream deviation are normalized and their values ​​are taken, and then the preset comprehensive pressure deviation calculation formula is used. Calculate the output line pressure deviation. ; All are preset partition deviation weighting coefficients; by weighted summation and integration of the three-segment deviations, the weighting coefficients are set according to the degree of influence of each segment on the line pressure stability, and the segment deviations are transformed into the overall line evaluation value.

[0060] S4. Dynamic Balance of Line Pressure: Based on a preset deviation threshold, the line pressure deviation is divided into three line pressure deviation intervals. These three intervals are arranged in ascending order and labeled as Level 1, Level 2, and Level 3 deviation intervals, respectively. When the line pressure deviation of the reagent delivery line is in the Level 1 deviation interval, the generated line status is stable, with no infusion constant pressure command. When it is in the Level 2 deviation interval, the generated line status is pressure deviation, and the infusion constant pressure command is adjusted by the valve control adjustment group. When it is in the Level 3 deviation interval, the generated line status is abnormal pressure deviation, and the infusion constant pressure command is emergency control, such as opening the valve core of the valve control adjustment group to the maximum.

[0061] The overall control interaction module includes a digestion treatment evaluation unit (an analysis system for evaluating whether the liquid addition data meets the process requirements) and a visualization unit (such as a touch screen and host computer for displaying reports). The digestion treatment evaluation unit evaluates the sample after liquid addition, outputs a sample digestion treatment report, and sends it to the visualization unit for report display.

[0062] The above-described embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to limit it. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A multifunctional sample digestion and processing platform, characterized in that, include: The sample identification and preprocessing module is used to identify and preprocess the samples to obtain the basic information of each sample. The multi-reagent automatic liquid addition module uses a preset reagent delivery line to add reagents stored in a preset reagent storage unit to each pre-sample to obtain a liquid-added sample, and optimizes the liquid addition process by using a preset fluid control liquid addition unit. The fluid control liquid dispensing unit includes a constant pressure liquid storage unit and a dynamic pressure balancing unit, which are used for optimized execution of liquid dispensing. The constant pressure liquid storage unit is used to perform constant pressure compensation analysis on the reagent liquid storage unit to obtain the constant pressure command for the liquid storage and to execute the command. The dynamic pressure balancing unit is used to perform pressure balance analysis on the reagent delivery line to obtain the constant pressure command for the infusion and to execute the command. The overall control and interaction module includes a digestion treatment evaluation unit and a visualization unit. The digestion treatment evaluation unit evaluates the sample after liquid addition, outputs a sample digestion treatment report, and sends it to the visualization unit for report display.

2. The multifunctional sample digestion and processing platform according to claim 1, characterized in that, The process of identifying and preprocessing samples to obtain basic sample information specifically involves: Based on the preset sample identification technology, each sample is identified to obtain the sample type and sample mode corresponding to the sample. The sample mode includes gaseous sample, liquid sample and solid sample. When the sample mode corresponds to a solid sample, the corresponding sample is crushed to obtain the processed sample. The processed sample and the other samples are marked as pre-samples. Each pre-sample is matched with the pre-stored sample process library in the database to obtain the corresponding preset digestion process parameters. The preset digestion process parameters and corresponding sample types of each pre-sample are packaged together to obtain the basic sample information.

3. The multifunctional sample digestion and processing platform according to claim 1, characterized in that, The specific analysis steps for obtaining the constant pressure command of the reagent storage unit through constant pressure compensation analysis are as follows: Based on the preset constant pressure analysis time interval, the constant pressure analysis time point is obtained, and data is collected from the reagent storage unit to obtain storage pressure data, liquid level data and storage temperature data; The system analyzes the liquid pressure data, liquid level data, and liquid temperature data to output the baseline coupling value, dynamic interference value, and feedback correction value. The benchmark coupling value, dynamic disturbance value, and feedback correction value corresponding to the current constant pressure analysis time point are substituted into the preset coupling compensation formula to calculate and output the final compensation pressure value. The final compensation pressure value at the current constant pressure analysis time point is used as the pressure adjustment target value, and the output liquid storage constant pressure command is to adjust the real-time liquid storage pressure value to the pressure adjustment target value.

4. The multifunctional sample digestion and processing platform according to claim 3, characterized in that, The specific steps for analyzing the liquid pressure data, liquid level data, and liquid temperature data to output reference coupling values, dynamic interference values, and feedback correction values ​​are as follows: The real-time storage temperature at the current constant pressure analysis time point is obtained based on the storage temperature data; the reference viscosity and reagent viscosity values ​​for the preset adaptation reference pressure and standard temperature of each reagent are obtained based on the database. The baseline coupling value is calculated and output using a preset baseline coupling calculation formula. The real-time liquid temperature and standard viscosity are input into a preset real-time reagent viscosity calculation formula to calculate the reagent viscosity at the real-time temperature; the real-time liquid level is obtained based on the liquid level data, and the liquid level at the previous constant pressure analysis time point is obtained. The difference between the real-time liquid level and the liquid level at the previous constant pressure analysis time point is calculated and marked as the liquid level change value. The ratio of the liquid level change value to the duration of the constant pressure analysis time interval is calculated to obtain the liquid level change rate; the real-time liquid level, reference density, reagent viscosity at the real-time temperature, and liquid level change rate are substituted into a preset dynamic interference calculation formula to calculate the dynamic interference value. Historical pressure compensation data is extracted from the database. Multiple historical pressure compensation values ​​and corresponding historical measured pressure values ​​(i.e., real-time storage pressure values ​​at historical constant pressure analysis time points corresponding to each historical pressure compensation value) are obtained from this data. The pressure difference is calculated by subtracting the historical pressure compensation values ​​from the historical measured pressure values, and the absolute value of the pressure difference is recorded as the compensation error value. Real-time storage pressure values ​​are obtained based on the storage pressure data at the current constant pressure analysis time point. The real-time storage pressure value is calculated by subtracting the real-time storage pressure value from the benchmark coupling value. A feedback correction value is then calculated and output using a preset feedback correction calculation formula to evaluate the compensation error value and the real-time pressure deviation.

5. The multifunctional sample digestion and processing platform according to claim 1, characterized in that, Pressure balance analysis of the reagent delivery line is performed to obtain a constant infusion pressure command, and the specific execution steps are as follows: Obtain the pre-deployed valve control adjustment groups for each reagent delivery line, and divide each reagent delivery line into multiple delivery segments based on the valve control adjustment groups. The delivery segments include an upstream delivery segment, a valve control adjustment segment, and a downstream buffer segment. The parameters of the upstream conveying section, the valve-controlled regulation section, and the downstream buffer section are collected by pre-deployed sensors. The upstream conveying section parameters include upstream conveying pressure, upstream conveying flow rate, and reagent temperature. The valve-controlled regulation section parameters include the pressure before the valve core, the pressure after the valve core, the reagent viscosity in the valve-controlled section, and the valve-controlled drive voltage. The downstream buffer section parameters include the end pressure of the downstream buffer section and the fluid pressure pulsation frequency. The upstream deviation is obtained by analyzing the parameters of the upstream conveying section; the valve control deviation is obtained by analyzing the parameters of the valve control regulating section; the downstream deviation is obtained by analyzing the parameters of the downstream buffer section; and the line pressure deviation is obtained by comprehensively calculating the upstream deviation, valve control deviation, and downstream deviation. The line pressure deviation is obtained by comprehensively calculating the upstream deviation, valve control deviation, and downstream deviation. Specifically, the upstream deviation, valve control deviation, and downstream deviation are normalized and their values ​​are taken. The line pressure deviation is then calculated and output using a preset comprehensive pressure deviation calculation formula. By analyzing the deviation of the line pressure, a constant pressure command for fluid delivery is output.

6. The multifunctional sample digestion and processing platform according to claim 5, characterized in that, The upstream deviation is obtained by analyzing the upstream transport section parameters, specifically as follows: upstream transport pressure, upstream transport flow rate, and reagent temperature are identified by identifying the upstream transport section parameters; upstream inlet pressure and upstream outlet pressure are obtained based on the upstream transport pressure; and the difference between the upstream inlet pressure and the upstream outlet pressure is marked as the upstream pressure change. Input the upstream pressure change, upstream flow rate, and reagent temperature values ​​into the preset upstream deviation calculation formula to calculate and output the upstream deviation degree.

7. The multifunctional sample digestion and processing platform according to claim 6, characterized in that, The process of analyzing the parameters of the valve-controlled adjustment section to obtain the valve control deviation specifically involves: identifying the parameters of the valve-controlled adjustment section to obtain the pressure before the valve core, the pressure after the valve core, the reagent viscosity of the valve-controlled section, and the valve control driving voltage; and inputting the values ​​of each valve-controlled adjustment section parameter into a preset valve control section deviation calculation formula. Calculate the output valve control deviation. ;in, These are the pressure before the valve core and the pressure after the valve core, respectively. These are the reagent viscosity and valve-controlled drive voltage in the valve-controlled section, respectively. This is the rated drive voltage; Rated pressure drop designed for valve-controlled regulating sections.

8. The multifunctional sample digestion and processing platform according to claim 7, characterized in that, The downstream deviation is obtained by analyzing the parameters of the downstream buffer section. Specifically, this involves obtaining the terminal pressure and fluid pressure pulsation frequency of the downstream buffer section based on the parameters, and then calculating the downstream deviation using a preset formula. The downstream deviation is output by calculating the values ​​of the terminal pressure and the fluid pressure pulsation frequency. ;in, These are the terminal pressure and fluid pressure pulsation frequencies, respectively. Set a target pressure for the end of the database; This is the fluid pulsation correction factor; The rated pressure drop is preset for the downstream buffer section.

9. The multifunctional sample digestion and processing platform according to claim 8, characterized in that, The process of analyzing the deviation of the line pressure and outputting a constant infusion pressure command specifically involves: Based on a preset deviation threshold, the pressure deviation of the reagent delivery line is divided into three pressure deviation intervals. These three intervals are arranged in ascending order and labeled as Level 1, Level 2, and Level 3 deviation intervals, respectively. When the pressure deviation of the reagent delivery line is in the Level 1 deviation interval, the generated line status is stable, and there is no constant pressure command for infusion. When it is in the Level 2 deviation interval, the generated line status is pressure deviation, and the constant pressure command for infusion is adjusted by the valve control adjustment group. When it is in the Level 3 deviation interval, the generated line status is abnormal pressure deviation, and the constant pressure command for infusion is emergency control.

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