Medium-chain triglyceride nano-composite emulsion and preparation method thereof
By introducing etherified cellulose nanoparticles into medium-chain triglyceride (MCT) emulsions, the physical stability problem of MCT emulsions was solved, achieving particle size stability and uniformity, thus improving the user experience of cosmetics.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- HUBEI CHUYI NEW MATERIAL CO LTD
- Filing Date
- 2026-03-10
- Publication Date
- 2026-05-26
AI Technical Summary
When medium-chain triglyceride (MCT) emulsions are used in cosmetics, their insufficient physical stability leads to an increase in droplet size and a wider distribution, resulting in stratification or precipitation, which affects spreadability, penetration, and skin feel.
Ether-esterified nanocellulose (CNF) was used as a stabilizer to introduce rigid surface anchoring and flexible steric hindrance structures into the MCT emulsion through esterification and mercapto-olefin click reaction, forming a stable nanocomposite emulsion.
It improves the stability and uniformity of MCT emulsions, maintains fine particle size, enhances spreadability and refreshing feel, adapts to thermal stress and centrifugal force, and extends shelf life.
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Abstract
Description
Technical Field
[0001] This invention belongs to the field of nanoemulsion technology, specifically, it relates to a medium-chain triglyceride nanocomposite emulsion and its preparation method. Background Technology
[0002] Medium-chain triglycerides (MCTs) are triglycerides formed by the esterification reaction of medium-chain fatty acids containing 6-12 carbon atoms with glycerol. Due to their small molecular weight and unique metabolic pathway, MCTs have been widely used in medical nutrition, special diets, and the food industry. Furthermore, due to their extremely high biocompatibility and mildness, they have become a popular base oil in the cosmetics industry.
[0003] In the cosmetics industry, MCT's application value is particularly prominent. Firstly, its low viscosity gives products excellent spreadability, easily forming a uniform thin layer on the skin's surface. Secondly, its small molecular size and polarity similar to the skin's lipid barrier give it good skin permeability, helping to carry active ingredients into the stratum corneum. More importantly, compared to traditional mineral oils or long-chain plant oils, MCT has an extremely refreshing and non-greasy feel, solving the problems of heavy, suffocating oily formulas. Therefore, it is widely used in high-end serums, creams, lotions, sunscreens, and makeup removers to enhance the user experience and efficacy penetration.
[0004] However, emulsions prepared using MCT as the oil phase, especially nanoemulsion systems aiming for efficient delivery of active ingredients, have long faced a key technical bottleneck: insufficient physical stability. MCT itself has relatively weak polarity, and in emulsion systems, it tends to reduce its surface energy through Ostwald ripening and aggregation. This leads to an increase in droplet size and wider distribution during storage (especially after temperature fluctuations, centrifugation, or prolonged standing), resulting in visible layering or sedimentation, and the loss of its core advantages: reduced spreadability, potentially causing a grainy or rough feel upon application; weakened penetration; and a greasy feel replaced by a refreshing texture. Therefore, fundamentally strengthening the structure of MCT droplets and inhibiting their aggregation and fusion is a core technical challenge for improving the quality and shelf life of related cosmetics.
[0005] Therefore, developing a novel stabilizer that can combine with MCT oil and simultaneously provide steric hindrance and mechanical strengthening effects is of significant industrial value for constructing high-performance MCT nanocomposite emulsions. Summary of the Invention
[0006] In order to solve the technical problems mentioned in the background art, the purpose of this invention is to provide a medium-chain triglyceride nanocomposite emulsion and its preparation method.
[0007] The objective of this invention can be achieved through the following technical solutions:
[0008] A medium-chain triglyceride nanocomposite emulsion includes medium-chain triglycerides, glycerol, emulsifying aids and deionized water, with an etherified CNF added as a stabilizer to improve the droplet structure and stability;
[0009] Specifically, the etherified CNF is prepared by the following steps:
[0010] Step A1: Under ice-water bath and continuous nitrogen protection, CNF dry powder is dispersed in anhydrous tetrahydrofuran to form a uniform dispersion. Methacrylamide chloride is slowly added to control the system temperature to not exceed 10°C. After returning to room temperature, triethylamine is added and the temperature is raised to 40-55°C to carry out the esterification reaction. After the reaction is completed, the bottom concentrate is centrifuged and washed with water to separate the aqueous phase. The residue is then filtered through a filter membrane and dried to obtain the esterification intermediate.
[0011] Furthermore, the ratio of CNF dry powder, methacryloyl chloride, triethylamine and anhydrous tetrahydrofuran is 10g:15-20mmol:8-12mL:90-120mL. During the above reaction, methacryloyl chloride esterifies with the hydroxyl groups on CNF molecules, introducing an acrylate structure on the surface.
[0012] Step A2: Premix the esterification intermediate, mercapto polyethylene oxide and dichloromethane, then add the photoinitiator and mix well. Place the mixture under ultraviolet irradiation to carry out the addition reaction. After the reaction is completed, centrifuge and concentrate, dialyze and then evaporate to dryness to obtain etherified CNF.
[0013] Furthermore, the ratio of thiol content of the esterification intermediate, thiol polyethylene oxide, photoinitiator, and dichloromethane is 10g:8-11mmol:0.1-0.15g:150-200mL. The thiol group of the thiol polyethylene oxide undergoes addition with the acrylate structure grafted onto the esterification intermediate molecule, introducing a hydrophilic chain into the polyethylene oxide.
[0014] A method for preparing a medium-chain triglyceride nanocomposite emulsion, specifically comprising:
[0015] Step S1: Premix glycerol, emulsifying agent and etherified CNF, then add deionized water to prepare an aqueous phase;
[0016] Step S2: Medium-chain triglycerides are added to the aqueous phase at a uniform rate and sheared and dispersed to prepare a crude emulsion;
[0017] Step S3: The crude emulsion is subjected to two-stage high-pressure homogenization to obtain a medium-chain triglyceride nanocomposite emulsion.
[0018] Furthermore, the content of medium-chain triglycerides is 6.8-9.2 wt%, at which the emulsion has good stability and a high degree of refreshing feel.
[0019] Furthermore, the amount of etherified CNF used is 18-26 wt% of medium-chain triglycerides, at which the droplet uniformity and stability are good.
[0020] Furthermore, the rotation speed for shear dispersion is 8000-12000 rpm, and the processing time is 5-8 min.
[0021] Furthermore, the pressures of the two-stage high-pressure homogenization treatment were 80 MPa and 120 MPa, respectively, and the treatment times were 150-200 s and 60-100 s, respectively.
[0022] The beneficial effects of this invention are:
[0023] This invention uses nanocellulose (CNF) as a matrix and prepares an etherified CNF through chemical modification. Introducing this CNF into an emulsion system as a stabilizer achieves significantly better results than traditional techniques. The core mechanism lies in the synergistic stabilizing effect triggered by the unique dual-affinity design of the etherified CNF molecule, as detailed below:
[0024] First, the methacrylate structure grafted onto the rigid backbone of CNF via esterification has hydrophobic ester groups on its side chains that are similar in structure to medium-chain triglycerides. Based on the principle of "like dissolves like," there is a strong van der Waals affinity between the two. This allows the etherified CNF to spontaneously and irreversibly anchor at the interface of MCT oil droplets during emulsification, acting like a rigid "nano-armor" for the droplets. This Pickering stabilization mechanism based on solid particle adsorption fundamentally changes the problem of weak interfacial films caused by the dynamic adsorption-desorption of traditional small-molecule surfactants, providing a primary mechanical barrier against droplet aggregation.
[0025] Secondly, the long polyethylene oxide (PEO) chains further grafted via the mercapto-olefin click reaction play a crucial role in steric stabilization. PEO is a highly hydrophilic and flexible ether chain. When the hydrophobic portion of the etherified CNF is anchored inside the oil droplet, a large number of PEO chains extend fully into the external aqueous phase, forming a thick hydration layer. When two CNF-stabilized droplets approach each other due to Brownian motion, these extended PEO chains first spatially overlap, generating a strong entropic repulsion force that effectively prevents close contact and fusion of the oil droplets. More importantly, the introduction of PEO chains forms a flexible buffer layer between the rigid framework of the CNF and the liquid core of the oil droplet, greatly enhancing the deformation tolerance of the entire interfacial film under thermal motion or shear stress, thereby inhibiting aggregation caused by interfacial film rupture.
[0026] Furthermore, the etherified CNFs that are not adsorbed onto the interface and remain dispersed in the aqueous phase can form a dense hydrogen bond network with water molecules due to the large number of hydroxyl groups on the CNF backbone and the ether oxygen atoms on the PEO chain. This interaction results in the structuring and weak gelation of the continuous phase (aqueous phase), with a moderate increase in viscosity. This significantly slows down the sedimentation or buoyancy of emulsion droplets due to gravity (i.e., Stokes sedimentation is suppressed), and also effectively hinders the diffusion of oil phase molecules through the aqueous phase during Ostwald ripening, providing a secondary macroscopic network barrier for the long-term stability of the emulsion.
[0027] In summary, the etherified CNF of this invention creatively combines the interfacial anchoring advantages of rigid nanoparticles, the steric hindrance advantages of flexible polymer chains, and the gelation advantages of biopolymer networks. This synergistic effect results in a fine and uniform initial particle size in the prepared MCT nanoemulsion, which maintains particle size stability and system homogeneity even under harsh conditions such as thermal stress, centrifugal force, and long-term storage. In end-use cosmetics, this ultra-stable nanostructure directly translates into excellent spreadability, a refreshing and non-greasy skin feel, and the ability to form a uniform, breathable functional film on the skin surface, laying a solid foundation for the effective delivery of high-end active ingredients. Detailed Implementation
[0028] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.
[0029] Example 1: Preparation of medium-chain triglyceride nanocomposite emulsion. The specific implementation process is as follows:
[0030] I. Preparation of Ether-Esterified CNF
[0031] Step A1: Under ice-water bath and continuous nitrogen protection, CNF dry powder (TLP002) and anhydrous tetrahydrofuran were ultrasonically dispersed to form a uniform dispersion. Methacrylamide chloride was slowly added, and the system temperature was controlled not to exceed 10°C. The ice-water bath and nitrogen flow were removed, and the mixture was allowed to return to room temperature naturally. Triethylamine was added, and the temperature was raised to 40°C. The esterification reaction was carried out by stirring for 15 hours. The ratio of CNF dry powder, methacrylamide chloride, triethylamine, and anhydrous tetrahydrofuran was 10 g: 15 mmol: 8 mL: 90 mL.
[0032] After the reaction is complete, centrifuge to collect the bottom concentrate, wash with water and separate the aqueous phase, then use a filter membrane to dialyze out the residue and dry it to obtain the esterification intermediate.
[0033] Step A2: Premix the esterification intermediate, mercapto polyethylene oxide (Xi'an Ruixi Biotechnology Co., Ltd., molecular weight Mn≈5000) and dichloromethane, then add the photoinitiator (photoinitiator 1173) and mix well. Place the mixture under ultraviolet irradiation (main wavelength 365nm, power 100W, distance from the light source 10cm) and stir for 2.2h for addition reaction. The mercapto content of the esterification intermediate and mercapto polyethylene oxide, and the ratio of photoinitiator to dichloromethane are 10g:8mmol:0.1g:150mL. After the reaction is completed, centrifuge and concentrate, dialyze and then evaporate to dryness to obtain etherified CNF.
[0034] II. Formulation of Nanocomposite Emulsions
[0035] Preparation of materials: By weight percentage, medium-chain triglycerides 6.8wt%, glycerol 1.6wt%, emulsifying agent (PEG-40 hydrogenated castor oil) 0.6wt%, etherified CNF 18wt% of medium-chain triglycerides, and the balance is deionized water.
[0036] Ingredients: Add the prepared glycerol, emulsifying agent and etherified CNF to the mixture and stir to premix. Then add deionized water to prepare an aqueous phase and medium-chain triglycerides as the oil phase.
[0037] Primary emulsification: The aqueous phase was sheared and dispersed at 8000 rpm, and the medium-chain triglycerides in the oil phase were added at a uniform rate for 8 min to prepare a crude emulsion.
[0038] High-pressure homogenization: The crude emulsion was transferred into a high-pressure homogenizer and treated at 80MPa and 120MPa for 200s and 60s respectively. Through two-stage homogenization, a medium-chain triglyceride nanocomposite emulsion was obtained.
[0039] Example 2: Preparation of medium-chain triglyceride nanocomposite emulsion, the specific implementation process is as follows:
[0040] I. Preparation of Ether-Esterified CNF
[0041] Step A1: Under ice-water bath and continuous nitrogen protection, CNF dry powder and anhydrous tetrahydrofuran were ultrasonically dispersed to form a uniform dispersion. Methacrylamide chloride was slowly added, and the system temperature was controlled not to exceed 10°C. The ice-water bath and nitrogen flow were removed, and the mixture was allowed to return to room temperature naturally. Triethylamine was added, and the temperature was raised to 55°C. The esterification reaction was stirred for 10 hours. The ratio of CNF dry powder, methacrylamide chloride, triethylamine, and anhydrous tetrahydrofuran was 10 g: 20 mmol: 12 mL: 120 mL.
[0042] After the reaction is complete, centrifuge to collect the bottom concentrate, wash with water and separate the aqueous phase, then use a filter membrane to dialyze out the residue and dry it to obtain the esterification intermediate.
[0043] Step A2: Premix the esterification intermediate, mercapto polyethylene oxide and dichloromethane, then add the photoinitiator and mix well. Place the mixture under ultraviolet irradiation and stir for 1.5 h for addition reaction. The mercapto content of the esterification intermediate and mercapto polyethylene oxide, and the ratio of photoinitiator to dichloromethane are 10 g: 11 mmol: 0.15 g: 200 mL. After the reaction is completed, centrifuge and concentrate, dialyze and then evaporate to dryness to obtain etherified CNF.
[0044] II. Formulation of Nanocomposite Emulsions
[0045] Preparation of materials: By weight percentage, medium-chain triglycerides 9.2 wt%, glycerol 1.2 wt%, emulsifying agent 0.4 wt%, etherified CNF 26 wt% of medium-chain triglycerides, and the balance is deionized water.
[0046] Ingredients: Add the prepared glycerol, emulsifying agent and etherified CNF to the mixture and stir to premix. Then add deionized water to prepare an aqueous phase and medium-chain triglycerides as the oil phase.
[0047] Primary emulsification: The aqueous phase was sheared and dispersed at 12,000 rpm, and medium-chain triglycerides in the oil phase were added at a uniform rate for 5 min to prepare a crude emulsion.
[0048] High-pressure homogenization: The crude emulsion was transferred into a high-pressure homogenizer and treated at 80 MPa and 120 MPa for 150 s and 100 s respectively. Through two-stage homogenization, a medium-chain triglyceride nanocomposite emulsion was obtained.
[0049] Example 3: Preparation of medium-chain triglyceride nanocomposite emulsion, the specific implementation process is as follows:
[0050] I. Preparation of Ether-Esterified CNF
[0051] Step A1: Under ice-water bath and continuous nitrogen protection, CNF dry powder and anhydrous tetrahydrofuran were ultrasonically dispersed to form a uniform dispersion. Methacrylamide chloride was slowly added, and the system temperature was controlled not to exceed 10°C. The ice-water bath and nitrogen flow were removed, and the mixture was allowed to return to room temperature naturally. Triethylamine was added, and the temperature was raised to 50°C. The esterification reaction was stirred for 12 hours. The ratio of CNF dry powder, methacrylamide chloride, triethylamine, and anhydrous tetrahydrofuran was 10 g: 18 mmol: 10 mL: 100 mL.
[0052] After the reaction is complete, centrifuge to collect the bottom concentrate, wash with water and separate the aqueous phase, then use a filter membrane to dialyze out the residue and dry it to obtain the esterification intermediate.
[0053] Step A2: Premix the esterification intermediate, mercapto polyethylene oxide and dichloromethane, then add the photoinitiator and mix well. Place the mixture under ultraviolet irradiation and stir for 2 hours for addition reaction. The mercapto content of the esterification intermediate and mercapto polyethylene oxide, and the ratio of photoinitiator to dichloromethane are 10g:10mmol:0.13g:180mL. After the reaction is completed, centrifuge and concentrate, dialyze and then evaporate to dryness to obtain etherified CNF.
[0054] II. Formulation of Nanocomposite Emulsions
[0055] Preparation of materials: By weight percentage, medium-chain triglycerides 7.5wt%, glycerol 1.5wt%, emulsifying agent 0.5wt%, etherified CNF 22wt% of medium-chain triglycerides, and the balance is deionized water.
[0056] Ingredients: Add the prepared glycerol, emulsifying agent and etherified CNF to the mixture and stir to premix. Then add deionized water to prepare an aqueous phase and medium-chain triglycerides as the oil phase.
[0057] Primary emulsification: The aqueous phase was sheared and dispersed at 10,000 rpm, and medium-chain triglycerides in the oil phase were added at a uniform rate for 6 minutes to prepare a crude emulsion.
[0058] High-pressure homogenization: The crude emulsion was transferred into a high-pressure homogenizer and treated at 80 MPa and 120 MPa for 180 s and 80 s respectively. Through two-stage homogenization, a medium-chain triglyceride nanocomposite emulsion was obtained.
[0059] Example 4: Preparation of medium-chain triglyceride nanocomposite emulsion. The specific implementation process is as follows:
[0060] I. Preparation of Ether-Esterified CNF
[0061] Step A1: Under ice-water bath and continuous nitrogen protection, CNF dry powder and anhydrous tetrahydrofuran were ultrasonically dispersed to form a uniform dispersion. Methacrylamide chloride was slowly added, and the system temperature was controlled not to exceed 10°C. The ice-water bath and nitrogen flow were removed, and the mixture was allowed to return to room temperature naturally. Triethylamine was added, and the temperature was raised to 45°C. The esterification reaction was carried out by stirring for 14 hours. The ratio of CNF dry powder, methacrylamide chloride, triethylamine, and anhydrous tetrahydrofuran was 10 g: 15 mmol: 10 mL: 110 mL.
[0062] After the reaction is complete, centrifuge to collect the bottom concentrate, wash with water and separate the aqueous phase, then use a filter membrane to dialyze out the residue and dry it to obtain the esterification intermediate.
[0063] Step A2: Premix the esterification intermediate, mercapto polyethylene oxide and dichloromethane, then add the photoinitiator and mix well. Place the mixture under ultraviolet irradiation and stir for 1.8 h for addition reaction. The mercapto content of the esterification intermediate and mercapto polyethylene oxide, and the ratio of photoinitiator to dichloromethane are 10 g: 10 mmol: 0.15 g: 180 mL. After the reaction is completed, centrifuge and concentrate, dialyze and then evaporate to dryness to obtain etherified CNF.
[0064] II. Formulation of Nanocomposite Emulsions
[0065] Preparation of materials: By weight percentage, medium-chain triglycerides 7.5wt%, glycerol 1.4wt%, emulsifying agent 0.4wt%, etherified CNF 20wt% of medium-chain triglycerides, and the balance is deionized water.
[0066] Ingredients: Add the prepared glycerol, emulsifying agent and etherified CNF to the mixture and stir to premix. Then add deionized water to prepare an aqueous phase and medium-chain triglycerides as the oil phase.
[0067] Primary emulsification: The aqueous phase was sheared and dispersed at 12,000 rpm, and medium-chain triglycerides in the oil phase were added at a uniform rate for 6 minutes to prepare a crude emulsion.
[0068] High-pressure homogenization: The crude emulsion was transferred into a high-pressure homogenizer and treated at 80 MPa and 120 MPa for 150 s and 80 s respectively. Through two-stage homogenization, a medium-chain triglyceride nanocomposite emulsion was obtained.
[0069] Comparative Example 1 follows the same implementation method as in Example 4, except that the etherified CNF is replaced with an equal amount of CNF dry powder, and the rest of the implementation process is exactly the same.
[0070] Comparative Example 2, following the implementation method of Example 4, replaced an equal amount of etherified CNF with carboxylated modified nanocellulose powder (TL002), with the remaining implementation process being exactly the same.
[0071] Droplet size and distribution: The droplets were measured using a Malvern laser particle size analyzer at 25°C. A small sample was diluted 100 times with deionized water before testing. The results were the average of three measurements.
[0072] Storage stability: The sample was sealed in a transparent glass bottle and placed in a 40℃ constant temperature accelerated test chamber. The appearance was observed periodically, and the particle size was measured after 30 days.
[0073] Centrifugation stability: Take 10 mL of sample into a centrifuge tube, centrifuge at 4000 rpm for 30 min, and observe the layer height ratio.
[0074] Spreadability: Using the plate method, 10 μL of emulsion was dropped onto a black PVC plate with a microsyringe, covered with a coverslip (weighing 2.5 g), and the spreading diameter was measured after standing for 1 min.
[0075] Oiliness assessment: conducted by 100 participants. 0.1 mL of sample was evenly applied to the back of the hand, observed, and scored (1 point: refreshing and oil-free; 5 points: very oily).
[0076] The specific test results are shown in Table 1:
[0077] Table 1
[0078]
[0079] As shown in Table 1, the emulsion prepared in the example has a smaller particle size, a more uniform distribution, and better stability under high temperature and long-term storage and centrifugation, which is conducive to maintaining a uniform emulsion state and can be used as a high-quality carrier. In addition, the emulsion has excellent spreadability and low greasiness, making it a high-quality carrier.
[0080] In the description of this specification, the references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.
[0081] The above description is merely an example and illustration of the present invention. Those skilled in the art can make various modifications or additions to the specific embodiments described, or use similar methods to replace them, as long as they do not deviate from the invention or exceed the scope defined in the claims, all of which should fall within the protection scope of the present invention.
Claims
1. A medium-chain triglyceride nano-emulsion complex comprising medium-chain triglyceride, glycerol, an emulsification aid, and deionized water, characterized in that, Add an etherified cellulose nanoparticle as a stabilizer; The etherified cellulose nanoparticles are prepared by the following steps: Step A1: Under ice-water bath and continuous nitrogen protection, the nanocellulose dry powder is dispersed in anhydrous tetrahydrofuran, and methacrylamide chloride is slowly added to control the system temperature to not exceed 10°C. After returning to room temperature, triethylamine is added and the temperature is raised to 40-55°C to carry out the esterification reaction. The esterification intermediate is obtained after treatment. Step A2: Premix the esterification intermediate, mercapto polyethylene oxide and dichloromethane, then add a photoinitiator and mix well. Place the mixture under ultraviolet irradiation to carry out an addition reaction, and obtain ether-esterified nanocellulose after treatment.
2. The medium-chain triglyceride nanoemulsion of claim 1, wherein, The ratio of nanocellulose powder, methacryloyl chloride, triethylamine and anhydrous tetrahydrofuran is 10g: 15-20mmol: 8-12mL: 90-120mL.
3. The medium-chain triglyceride nanoemulsion of claim 2, wherein the medium-chain triglyceride is selected from the group consisting of caprylic acid, capric acid, caprilic acid, and lauric acid. The ratio of esterification intermediate, mercapto content of mercapto polyethylene oxide, photoinitiator and dichloromethane is 10g: 8-11mmol: 0.1-0.15g: 150-200mL.
4. The medium-chain triglyceride nanoemulsion of claim 3, wherein the medium-chain triglyceride is present in an amount of about 0.1% to about 10% by weight of the total weight of the composition. The content of medium-chain triglycerides is 6.8-9.2 wt%.
5. The medium-chain triglyceride nanoemulsion of claim 4, wherein the medium-chain triglyceride is present in an amount of about 0.1% to about 10% by weight of the total weight of the composition. The amount of etherified nanocellulose used is 18-26 wt% of medium-chain triglycerides.
6. A method of preparing a medium-chain triglyceride nanoemulsion according to any one of claims 1 to 5, characterized in that, Specifically: Step S1: Premix glycerol, emulsifying agent and etherified cellulose nanoparticles, then add deionized water to prepare an aqueous phase; Step S2: Medium-chain triglycerides are added to the aqueous phase at a uniform rate and sheared and dispersed to prepare a crude emulsion; Step S3: The crude emulsion is subjected to two-stage high-pressure homogenization to obtain a medium-chain triglyceride nanocomposite emulsion.
7. The method for preparing a medium-chain triglyceride nanocomposite emulsion according to claim 6, characterized in that, The shearing dispersion speed is 8000-12000 rpm, and the processing time is 5-8 min.
8. The method for preparing a medium-chain triglyceride nanocomposite emulsion according to claim 6, characterized in that, The pressures of the two-stage high-pressure homogenization treatment were 80 MPa and 120 MPa, respectively, and the treatment times were 150-200 s and 60-100 s, respectively.