Anti-inflammatory and analgesic external traditional Chinese medicine powder for osteoarthritis and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to anti-inflammatory and analgesic external traditional Chinese medicine powder for osteoarthritis and a preparation method thereof, and the powder is prepared from the following raw materials in parts by weight: 6.7 parts of mirabilite, 2 parts of borneol, 1 part of fructus gardeniae, 0.7 part of rhizoma paridis, 0.7 part of radix aconiti, 0.7 part of radix aconiti agrestis, 0.6 part of caulis spatholobi, 1.3 parts of rheum officinale, 0.4 part of cassia twig and 0.6 part of radix achyranthis bidentatae. The preparation method comprises the following steps: weighing the medicinal materials according to the proportion, mixing, grinding at low temperature, controlling the temperature to be below 40 DEG C until uniform and fine powder is formed, and sieving, so as to obtain the traditional Chinese medicine powder. The powder has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, relieving swelling and pain, dispelling wind and eliminating dampness, and warming and activating meridians; the traditional Chinese medicine composition has the advantages of quick effect, exact curative effect, convenience in use and high safety on osteoarthritis (especially patients with red, swollen and heat pain symptoms). The preparation method is simple in process, easy to control and suitable for industrial production.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a topical Chinese medicine powder for treating osteoarthritis and its preparation method, which is particularly suitable for the adjunctive treatment of acute and chronic joint inflammation with symptoms of redness, swelling, heat and pain. Background Technology

[0002] Osteoarthritis (OA) is a chronic joint disease characterized by degenerative changes in articular cartilage and secondary bone hyperplasia. Clinically, it mainly manifests as joint pain, swelling, stiffness, and impaired mobility, severely impacting patients' quality of life. Currently, Western medicine treatment primarily involves oral or local injections of nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics. While these can relieve symptoms, long-term use can easily lead to side effects such as gastrointestinal, cardiovascular, and renal damage.

[0003] In the field of traditional Chinese medicine, topical ointments, powders, and patches are commonly used to treat arthritis and other arthralgia, offering advantages such as direct targeting of the affected area, minimal side effects, and ease of use. However, some existing topical Chinese medicine products still have shortcomings: firstly, some products have a slow onset of action, making it difficult to quickly relieve patients' acute pain; secondly, some formulas are complex, containing numerous ingredients, and the preparation process is cumbersome, resulting in high costs; thirdly, some products are highly irritating, and long-term application can easily cause skin allergies, itching, and other adverse reactions. Therefore, developing a topical Chinese medicine preparation that is relatively fast-acting, has a simplified formula, is easy to prepare, is safe to use, and has a clear therapeutic effect on the redness, swelling, heat, and pain symptoms of osteoarthritis has significant clinical importance and market value. Summary of the Invention

[0004] The purpose of this invention is to provide an anti-inflammatory and analgesic external Chinese medicine powder for osteoarthritis and its preparation method, so as to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, the present invention provides the following technical solution:

[0006] An anti-inflammatory and analgesic external Chinese medicine powder for osteoarthritis is made from the following raw materials in parts by weight: 6.7 parts Glauber's salt, 2 parts borneol, 1 part gardenia, 0.7 parts Paris polyphylla, 0.7 parts Aconitum carmichaelii, 0.7 parts Aconitum kusnezoffii, 0.6 parts Spatholobus suberectus, 1.3 parts rhubarb, 0.4 parts cinnamon twig, and 0.6 parts Achyranthes bidentata.

[0007] As a further aspect of the present invention, the powder is in the form of a powder that can be directly applied externally.

[0008] As a further aspect of the present invention, the powder can be mixed with vinegar or wine to form a paste for use.

[0009] As a further aspect of the present invention: the powder can be formulated into a gel ointment by adding pharmaceutical excipients and a transdermal penetration enhancer.

[0010] As a further aspect of the present invention: the gel ointment is a warm-applied ointment, and its specific composition by weight of the ingredients includes: 1000g of hot melt adhesive matrix; 250g of fine Chinese herbal powder; 12ml of clove oil; 12ml of azone; 1ml of liquid capsaicin; 12g of camphor; and 4g of menthol.

[0011] As a further aspect of the present invention: the gel plaster is a heat-applied plaster, and its specific composition by weight includes: 1000g of hot melt adhesive matrix; 250g of fine Chinese herbal powder; 12ml of clove oil; 12ml of azone; 2ml of liquid capsaicin; and 12g of camphor.

[0012] A method for preparing an anti-inflammatory and analgesic topical Chinese medicine powder for osteoarthritis as described in any of the preceding claims, comprising the following steps:

[0013] S1. Accurately weigh out the following proportions: 6.7 parts Glauber's salt, 2 parts borneol, 1 part gardenia, 0.7 parts Paris polyphylla, 0.7 parts Aconitum carmichaelii, 0.7 parts Aconitum kusnezoffii, 0.6 parts Spatholobus suberectus, 1.3 parts rhubarb, 0.4 parts cinnamon twig, and 0.6 parts Achyranthes bidentata.

[0014] S2. Mix the weighed medicinal materials evenly;

[0015] S3. Grind the mixed medicinal materials until the material becomes a uniform and fine powder;

[0016] S4. Sift the ground powder to collect fine powder that meets the particle size requirements, and seal it in packaging to obtain the Chinese herbal powder.

[0017] As a further aspect of the present invention: the grinding in step S3 is carried out using a low-temperature pulverizer or an ultrafine pulverizer.

[0018] As a further aspect of the present invention: the temperature during the grinding process in step S3 should be controlled to be below 40°C.

[0019] Compared with the prior art, the beneficial effects of the present invention are:

[0020] 1. Fast onset of action and definite curative effect: The ingredients such as borneol and Glauber's salt in the formula have good skin penetration and immediate cooling and analgesic effects. Combined with blood-activating and stasis-removing drugs, it can quickly relieve joint redness, swelling, heat and pain.

[0021] 2. Concise formula and scientific combination: It selects ten medicinal materials, with clear distinctions between the principal, assistant, adjuvant and guide herbs, and targets the core pathogenesis of osteoarthritis, namely "heat, toxicity, blood stasis and numbness", treating both the symptoms and the root cause;

[0022] 3. Safe to use and highly adaptable: Topical application avoids the systemic side effects of oral medications. By controlling the grinding temperature and application time, the risk of skin irritation and allergies is minimized.

[0023] 4. Simple preparation process and controllable quality: The preparation method is mainly physical grinding, the key process parameters (low temperature) are clear, it is easy to achieve standardization and large-scale production, and the product quality is stable;

[0024] 5. Wide range of applications: In addition to being suitable for osteoarthritis (especially lower limb joints), it also has good effects on acute or chronic sprains, strains, rheumatic pain, and early-stage local carbuncles and boils that belong to the syndrome of heat toxin and blood stasis. Detailed Implementation

[0025] The technical solution of this application will be further described in detail below with reference to specific embodiments.

[0026] The embodiments of this application are described in detail below. Examples of these embodiments are shown, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below are exemplary and are only used to explain this application, and should not be construed as limiting this application.

[0027] In one embodiment of the present invention, an anti-inflammatory and analgesic external Chinese medicine powder for osteoarthritis is composed of the following raw materials in parts by weight: 6.7 parts Glauber's salt, 2 parts borneol, 1 part gardenia, 0.7 parts Paris polyphylla, 0.7 parts Aconitum carmichaelii, 0.7 parts Aconitum kusnezoffii, 0.6 parts Spatholobus suberectus, 1.3 parts rhubarb, 0.4 parts cinnamon twig, and 0.6 parts Achyranthes bidentata.

[0028] Explanation: This formula uses Glauber's salt and borneol as the principal herbs. Glauber's salt clears heat, reduces swelling, softens hardened masses, and dissipates nodules, while borneol opens the orifices, disperses stagnation, clears heat, and relieves pain. The combination of these two herbs allows for rapid penetration, alleviating local redness, swelling, heat, and pain. Gardenia, Paris polyphylla, and rhubarb are the assistant herbs, enhancing their heat-clearing, detoxifying, blood-cooling, and swelling-reducing effects. Aconitum carmichaelii and Aconitum kusnezoffii dispel wind and dampness, warm the meridians, and relieve pain; Spatholobus suberectus invigorates blood, nourishes blood, relaxes muscles and tendons; and Cinnamomum cassia warms and unblocks the meridians. These herbs act as adjuvant herbs, targeting the "wind, cold, dampness, and blood stasis" pathogenesis of arthralgia. Achyranthes bidentata guides the medicine downwards, directly reaching the affected area in the lower limbs, and also invigorates blood, serving as the guiding herb. The entire formula combines cold and warm herbs, clearing and tonifying simultaneously, achieving the effects of clearing heat and detoxifying, invigorating blood and removing blood stasis, reducing swelling and relieving pain, dispelling wind and dampness, and warming and unblocking the meridians.

[0029] This invention provides a method for preparing the above-mentioned traditional Chinese medicine powder, comprising the following steps:

[0030] Preparation: Accurately weigh each of the above-mentioned dried and clean medicinal materials according to the weight proportions.

[0031] Mixing: Place the weighed medicinal materials into the mixing equipment and mix thoroughly.

[0032] Low-temperature grinding: The mixed medicinal materials are put into grinding equipment (such as a low-temperature pulverizer or an ultrafine pulverizer) for grinding. The key control point is that the material temperature must be kept below 40°C throughout the grinding process to prevent the loss of volatile components such as borneol and heat-sensitive active ingredients.

[0033] Sieving and Packaging: The ground powder is passed through an 80-120 mesh sieve to collect the fine powder and discard the coarse residue. The fine powder that meets the requirements is then sealed and packaged in a clean environment to obtain the finished powder.

[0034] As a further extended implementation, the powder can be formulated into a gel or ointment by adding pharmaceutical excipients and transdermal penetration enhancers.

[0035] The gel plaster is a warm-applied plaster, and its specific composition by weight includes: 1000g hot melt adhesive matrix; 250g fine powder of traditional Chinese medicine; 12ml clove oil; 12ml azone; 1ml liquid capsaicin; 12g camphor; and 4g menthol.

[0036] The gel plaster is a heat-applied plaster, and its specific composition by weight includes: 1000g hot melt adhesive matrix; 250g fine powder of traditional Chinese medicine; 12ml clove oil; 12ml azone; 2ml liquid capsaicin; and 12g camphor.

[0037] How to use

[0038] Take an appropriate amount of the powder of this invention, mix it with edible vinegar (such as rice vinegar) or low-alcohol white wine to form a paste of suitable consistency, and apply it evenly to the cleansed affected skin. It can be secured with gauze or medical tape. It is recommended to apply the powder for 2-4 hours each time, 1-2 times daily, avoiding overnight application to prevent skin irritation. Alternatively, the powder can be mixed with a base such as petroleum jelly or honey to form an ointment, extending the application time to 12-24 hours, once daily.

[0039] Sixty patients meeting the diagnostic criteria for osteoarthritis (knee joint) and exhibiting moderate to severe redness, swelling, and pain were randomly divided into a treatment group and a control group, with 30 patients in each group. The treatment group received the powder prepared according to the above-described embodiments, mixed with rice vinegar, applied twice daily for 3 hours each time. The control group received a commercially available anti-inflammatory and analgesic plaster. The treatment course was 7 days. Efficacy criteria: markedly effective (pain and swelling basically disappeared, joint function significantly improved), effective (symptoms alleviated), and ineffective (no change or worsening of symptoms). Results: The total effective rate in the treatment group was 93.3%, while it was 76.7% in the control group. The treatment group showed better results than the control group in terms of onset time (pain relief in most patients within 24-48 hours) and degree of swelling reduction, and no serious adverse skin reactions occurred.

[0040] This topical Chinese medicine powder for osteoarthritis, containing borneol and Glauber's salt, exhibits excellent skin penetration and immediate cooling and analgesic effects. Combined with blood-activating and stasis-removing herbs, it can quickly relieve joint redness, swelling, heat, and pain. Ten carefully selected medicinal herbs are used, with clear distinctions between principal, assistant, and adjuvant herbs, targeting the core pathogenesis of osteoarthritis—"heat, toxicity, stasis, and numbness"—treating both the symptoms and the root cause. Topical application avoids the systemic side effects of oral medications. By controlling the grinding temperature and application time, the risk of skin irritation and allergies is minimized. The preparation method primarily uses physical grinding, with clearly defined key process parameters (low temperature), facilitating standardized and large-scale production and ensuring stable product quality. In addition to being suitable for osteoarthritis (especially lower limb joints), it also shows good efficacy for acute or chronic sprains, strains, rheumatic pain, and early-stage local carbuncles and boils, all belonging to the heat-toxicity and stasis syndrome.

[0041] The above are merely preferred embodiments of the present invention. It should be noted that those skilled in the art can make several modifications and improvements without departing from the concept of the present invention, and these should also be considered within the scope of protection of the present invention. These will not affect the effectiveness of the implementation of the present invention or the practicality of the patent.

Claims

1. A topical traditional Chinese medicine powder for anti-inflammatory and analgesic purposes in osteoarthritis, characterized in that, It is made from the following ingredients in parts by weight: 6.7 parts Glauber's salt, 2 parts borneol, 1 part gardenia, 0.7 parts Paris polyphylla, 0.7 parts Aconitum carmichaelii, 0.7 parts Aconitum kusnezoffii, 0.6 parts Spatholobus suberectus, 1.3 parts rhubarb, 0.4 parts cinnamon twig, and 0.6 parts Achyranthes bidentata.

2. The topical Chinese medicine powder for anti-inflammatory and analgesic purposes for osteoarthritis according to claim 1, characterized in that, The powder is in the form of a powder that can be applied directly to the skin.

3. The topical Chinese medicine powder for anti-inflammatory and analgesic purposes for osteoarthritis according to claim 1, characterized in that, The powder can be mixed with vinegar or wine to form a paste for use.

4. The topical Chinese medicine powder for anti-inflammatory and analgesic purposes for osteoarthritis according to claim 1, characterized in that, The powder can be formulated into a gel or ointment by adding pharmaceutical excipients and transdermal penetration enhancers.

5. The topical Chinese medicine powder for anti-inflammatory and analgesic purposes for osteoarthritis according to claim 4, characterized in that, The gel plaster is a warm-applied plaster, and its specific composition by weight includes: 1000g hot melt adhesive matrix; 250g fine powder of traditional Chinese medicine; 12ml clove oil; 12ml azone; 1ml liquid capsaicin; 12g camphor; and 4g menthol.

6. The topical Chinese medicine powder for anti-inflammatory and analgesic purposes for osteoarthritis according to claim 4, characterized in that, The gel plaster is a heat-applied plaster, and its specific composition by weight includes: 1000g hot melt adhesive matrix; 250g fine powder of traditional Chinese medicine; 12ml clove oil; 12ml azone; 2ml liquid capsaicin; and 12g camphor.

7. A method for preparing a topical traditional Chinese medicine powder for anti-inflammatory and analgesic purposes for osteoarthritis as described in any one of claims 1-4, characterized in that, Includes the following steps: S1. Accurately weigh out the following proportions: 6.7 parts Glauber's salt, 2 parts borneol, 1 part gardenia, 0.7 parts Paris polyphylla, 0.7 parts Aconitum carmichaelii, 0.7 parts Aconitum kusnezoffii, 0.6 parts Spatholobus suberectus, 1.3 parts rhubarb, 0.4 parts cinnamon twig, and 0.6 parts Achyranthes bidentata. S2. Mix the weighed medicinal materials evenly; S3. Grind the mixed medicinal materials until the material becomes a uniform and fine powder; S4. Sift the ground powder to collect fine powder that meets the particle size requirements, and seal it in packaging to obtain the Chinese herbal powder.

8. The method for preparing the anti-inflammatory and analgesic external Chinese medicine powder for osteoarthritis according to claim 7, characterized in that, The grinding in step S3 is carried out using a cryogenic pulverizer or an ultrafine pulverizer.

9. The method for preparing the anti-inflammatory and analgesic external Chinese medicine powder for osteoarthritis according to claim 7, characterized in that, During the grinding process in step S3, the temperature should be controlled to be below 40℃.