Traditional Chinese medicine ointment for treating hyperostosis and soft tissue injury and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine, and discloses a traditional Chinese medicine ointment for treating hyperostosis and soft tissue injury and a preparation method thereof, the traditional Chinese medicine ointment is prepared by combining raw material medicines and auxiliary materials, the raw material medicines comprise knoxia root, lilac daphne flower bud, euphorbia kansui, liquorice and seaweed, and the auxiliary materials comprise oil and yellow lead. According to the external-use analgesic plaster, the euphorbia pekinensis, the lilac daphne flower bud and the euphorbia kansui have a synergistic effect, the effects of softening bone spurs of hyperosteogeny and resolving local phlegm stasis and retardation are remarkable, and compared with a conventional external-use analgesic plaster for hyperosteogeny, the external-use analgesic plaster can improve the hyperplasia state from the pathogenesis level; meanwhile, the formula is superior to a conventional safflower oil preparation in the aspects of absorption of hematoma caused by soft tissue injury and relieving speed and depth of swelling and pain caused by meridian blocking, and the recovery phase of acute injury can be shortened.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine ointment for treating hyperosteogeny and soft tissue injury and a preparation method thereof. BACKGROUND

[0002] Hyperosteogeny, also known as bone impediment in traditional Chinese medicine, is often found in people over middle age, and is related to factors such as weak constitution, degeneration, long-term strain, trauma, invasion of wind, cold and dampness, and the like, and is manifested as local pain, stiffness, and limited activity, and can compress nerves and blood vessels to cause limb numbness and radiating pain and the like.

[0003] Soft tissue injury, also known as tendon injury in traditional Chinese medicine, is pathological damage to skin, muscle, tendon, ligament, joint capsule and the like caused by acute trauma, chronic strain and the like, and is clinically manifested as local swelling, pain, ecchymosis and dysfunction.

[0004] The existing treatment methods have limitations, such as large side effects of western medicine, and the disadvantage of surgical treatment of western medicine that brings great risk to patients, such as easily injuring nerves to cause patients to suffer, and hyperosteogeny growing out again after several years of surgical treatment. Moreover, the treatment cost is high, and increases the burden of patients' families. Other traditional ointments have insufficient penetration and poor curative effect, and the present application provides a traditional Chinese medicine compound ointment with multiple targets and good transdermal absorption, which improves the release and penetration efficiency of active ingredients through a specific preparation process, and has the comprehensive effects of relaxing tendons and collaterals, promoting blood circulation to remove blood stasis, clearing heat to relieve swelling and pain, and softening and resolving nodules. SUMMARY

[0005] The present application aims at solving the defects in the prior art, and provides a traditional Chinese medicine ointment for treating hyperosteogeny and soft tissue injury and a preparation method thereof.

[0006] In order to achieve the above-mentioned purpose, the present application adopts the following technical scheme: A traditional Chinese medicine ointment for treating hyperosteogeny and soft tissue injury is prepared from raw medicinal materials and auxiliary materials, wherein the raw medicinal materials include Radix Dracorhodae, Daphne Genkwa, Kansuia, Radix Glycyrrhizae, and Sargassum, and the auxiliary materials include oil and yellow wax.

[0007] Radix Dracorhodae is bitter and cold in nature, and is meridian-entering lung, kidney and large intestine, and has the core effects of purging water and reducing fluid, and detoxifying and resolving nodules, and can break blood stasis and resolve nodules to eliminate pathological products of hyperosteogeny, and relieve swelling and nodules of soft tissue injury. Kansuia is bitter and cold in nature, and is meridian-entering lung, kidney and large intestine, and has the effects of purging water and reducing fluid, and resolving nodules, and can strengthen the effect of breaking blood stasis and resolving nodules, and help to disperse sputum and blood stasis and to organize hematoma after soft tissue injury. Seaweed is bitter and salty in taste, cold in nature, and enters the liver, stomach, and kidney meridians. Its functions include softening and dispersing nodules, clearing heat and promoting diuresis. It can soften bone spurs caused by bone hyperplasia, and at the same time dissipate local swellings caused by soft tissue injuries. It also has the effect of promoting diuresis and reducing swelling. Licorice has a sweet taste and neutral properties, and enters the spleen, stomach, heart, and lung meridians. Its functions include tonifying the spleen and replenishing qi, clearing heat and detoxifying, relieving pain, and harmonizing other medicines. It can alleviate the cold and cooling properties of other medicinal materials, reduce toxicity, guide the medicine directly to the affected area, and at the same time relieve pain symptoms. Daphne genkwa has a pungent and bitter taste, is warm in nature, and is poisonous. It enters the lung, spleen, and kidney meridians. Its functions include draining water and eliminating phlegm, relieving cough and eliminating parasites and healing sores. Its ability to break up blood stasis and dissipate nodules is strong. It can work together with Euphorbia pekinensis and Euphorbia kansui to enhance the effect of resolving phlegm and blood stasis in bone hyperplasia, while accelerating the dissipation of hematoma after soft tissue injury.

[0008] As a further description of the above technical solution: The raw material comprises the following components in parts by weight: 30-60 parts of Euphorbia pekinensis, 20-35 parts of Daphne genkwa, 25-45 parts of Euphorbia kansui, 30-50 parts of Glycyrrhiza uralensis, and 30-50 parts of Sargassum.

[0009] As a further description of the above technical solution: The raw material comprises the following components in parts by weight: 35-50 parts of Euphorbia pekinensis, 25-30 parts of Daphne genkwa, 25-40 parts of Euphorbia kansui, 35-45 parts of Glycyrrhiza uralensis, and 35-45 parts of Sargassum.

[0010] As a further description of the above technical solution: The raw material comprises the following components in parts by weight: 40-50 parts of Euphorbia pekinensis, 26-39 parts of Daphne genkwa, 30-40 parts of Euphorbia kansui, 38-42 parts of Glycyrrhiza uralensis, and 38-42 parts of Sargassum.

[0011] As a further description of the above technical solution: The raw material comprises the following components in parts by weight: 45 parts of Euphorbia pekinensis, 28 parts of Daphne genkwa, 35 parts of Euphorbia kansui, 40 parts of Glycyrrhiza uralensis, and 40 parts of Sargassum.

[0012] As a further description of the above technical solution: The amount of oil used is 3-4 times the total weight of the raw materials, and the amount of litharge is 1 / 3 of the total amount of oil.

[0013] As a further description of the above technical solution: The oil is sesame oil or peanut oil.

[0014] On the other hand, the present invention also provides a preparation method, comprising the following steps: Step 1: Weigh each raw material according to the weight ratio, rinse with clean water to remove mud and impurities, place in a ventilated and cool place to air dry until the moisture content is ≤10%, and then use a Chinese medicine slicer to cut into thin slices of 2-5mm thickness for later use; Step 2: Place the pre-treated medicinal materials into a ceramic jar, add 3-4 times the total weight of the raw materials in sesame oil or peanut oil, seal the jar, soak for 12-18 days in spring and winter, and 8-12 days in summer and autumn, stirring every 2-3 days during the process to ensure that the medicinal materials are fully soaked; Step 3: Pour the soaked herbs and oil into an iron pot. First, simmer at 100-120℃ for 30-60 minutes, stirring constantly to prevent the herbs from sticking to the pot, until the red euphorbia, kansui, and licorice turn light yellow, indicating that the active ingredients have begun to be extracted. Then, continue to simmer at 150-180℃ until the herbs turn dark black and become brittle. Turn off the heat and let it cool to room temperature. Filter the oil through an 80-mesh stainless steel filter, collect the filtered oil, and discard the dregs. Step 4: Pour the collected medicinal oil back into the pot and heat it at a temperature of ≥100℃ until the oil forms beads when dripped into water. Turn off the heat and let it cool naturally for 5-8 minutes. Add litharge (1 / 3 of the total weight of the medicinal oil) and stir quickly clockwise for 20-30 minutes to ensure that the litharge and medicinal oil are fully mixed. Immediately pour the hot ointment into cold water and soak for 24 hours, changing the cold water 2-3 times during this period to remove the fire toxicity and residual toxicity from the ointment. Drain the water to obtain the finished black plaster.

[0015] The present invention has the following beneficial effects: 0. In this invention, the synergistic effect of Euphorbia pekinensis, Daphne genkwa, and Euphorbia kansui significantly softens bone spurs and resolves local phlegm and blood stasis in osteophytes. Compared with conventional external pain relief patches for osteophytes, which can only relieve superficial pain, this solution can improve the osteophyte state from the pathogenesis level. At the same time, this formula is superior to conventional safflower oil preparations in terms of the speed and depth of hematoma absorption and relief of swelling and pain caused by meridian blockage in soft tissue injuries, and can shorten the recovery period of acute injuries.

[0016] 1. In this invention, licorice can effectively neutralize the toxicity and harshness of Euphorbia pekinensis, Daphne genkwa, and Euphorbia kansui, while seaweed helps to soften and disperse nodules. The entire formula takes into account both efficacy and safety. Compared with traditional Chinese medicine ointments containing litharge but lacking toxicity mitigation, this formula has low skin irritation and no obvious risk of liver and kidney toxicity, making it suitable for the elderly and people with sensitive constitutions. Detailed Implementation

[0017] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0018] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those familiar to those skilled in the art. Furthermore, any methods and materials similar to or equivalent to those described herein may be applied to this invention. The preferred embodiments and materials described herein are for illustrative purposes only and do not limit the scope of this application.

[0019] Unless otherwise specified, the experimental methods used in the following examples are conventional methods, and the experimental materials used in the following examples are all purchased from commercial channels.

[0020] Example 1: A traditional Chinese medicine ointment for treating bone hyperplasia and soft tissue injury and its preparation method, comprising the following raw material components in parts by weight: 30 parts of Euphorbia pekinensis, 25 parts of Euphorbia kansui, 20 parts of Daphne genkwa, 30 parts of Glycyrrhiza uralensis, and 30 parts of Sargassum. Weigh each raw material according to the above weight ratio, rinse 3 times with running water, air dry until the moisture content is ≤10%, and cut into 2mm thick slices; put them into a ceramic jar, add sesame oil three times the total weight of the raw materials, seal and soak for 18 days in winter, stirring once every 3 days at a speed of 20r / min for 5 minutes; pour the herbs and sesame oil into an electromagnetic heating pot, cook at 500W power and 100℃ for 60 minutes, stirring until the herbs such as red euphorbia turn light yellow, then change to 1200W power and 150℃ and cook until the herbs are charred and crispy, cool and filter through an 80-mesh filter to collect the medicinal oil; pour the medicinal oil back into the pot, cook over high heat until it reaches the state of dripping water forming beads, turn off the heat and cool for 8 minutes, add 1 / 3 of the total weight of the medicinal oil and dry litharge, stir at 30r / min for 30 minutes until the paste has a uniform texture, soak in 0-5℃ cold water for 24 hours, changing the cold water 3 times, take it out and drain to obtain the finished black plaster.

[0021] Example 2: A traditional Chinese medicine ointment for treating bone hyperplasia and soft tissue injury and its preparation method, comprising the following raw material components in parts by weight: 45 parts of Euphorbia pekinensis, 28 parts of Daphne genkwa, 35 parts of Euphorbia kansui, 40 parts of Glycyrrhiza uralensis, and 40 parts of Sargassum fusiforme. Weigh each raw material according to the above weight ratio, rinse 4 times with running water, air dry until the moisture content is ≤10%, and cut into 3mm thick slices; put them into a ceramic jar, add peanut oil with a total weight of 3.5 times the raw materials, seal and soak for 15 days in winter, stirring once every 2 days at a speed of 25r / min for 8 minutes; pour the herbs and oil into an electromagnetic heating pot, cook at 650W power and 110℃ for 45 minutes, stirring until the herbs such as red euphorbia turn light yellow, then change to 1350W power and cook at 165℃ until the herbs are charred and crispy, cool and filter through an 80-mesh filter to collect the medicinal oil; pour the medicinal oil back into the pot, cook over high heat until it reaches the state of dripping water forming beads, turn off the heat and cool for 6 minutes, add 1 / 3 of the total weight of the medicinal oil and dry litharge, stir at 40r / min for 25 minutes until the paste has a uniform texture, soak in 0-5℃ cold water for 24 hours, changing the cold water twice, take it out and drain to obtain the finished black plaster.

[0022] Example 3: A traditional Chinese medicine ointment for treating bone hyperplasia and soft tissue injury and its preparation method, comprising the following raw material components in parts by weight: 60 parts of Euphorbia pekinensis, 35 parts of Daphne genkwa, 45 parts of Euphorbia kansui, 50 parts of Glycyrrhiza uralensis, and 50 parts of Sargassum. Weigh each raw material according to the above weight ratio, rinse 5 times with running water, air dry until the moisture content is ≤10%, and cut into 5mm thick slices; put them into a ceramic jar, add sesame oil four times the total weight of the raw materials, seal and soak for 8 days in summer, stirring once every 2 days at a speed of 30r / min for 10 minutes; pour the herbs and oil into an electromagnetic heating pot, cook at 800W power and 120℃ for 30 minutes, stirring until the herbs such as Euphorbia pekinensis turn light yellow, then change to 1500W power and cook at 180℃ until the herbs are charred and crispy, cool and filter through an 80-mesh filter to collect the medicinal oil; pour the medicinal oil back into the pot, cook over high heat until it reaches the state of dripping water forming beads, turn off the heat and cool for 5 minutes, add 1 / 3 of the total weight of the medicinal oil and dry litharge, stir at 50r / min for 20 minutes until the paste has a uniform texture, soak in 0-5℃ cold water for 24 hours, changing the cold water 3 times, take it out and drain to obtain the finished product.

[0023] Results Analysis Fifty patients with osteoproliferative disease and 50 patients with soft tissue injury were recruited and randomly divided into a treatment group and a control group, with 25 patients in each group. The osteoproliferative disease treatment group consisted of 16 males and 9 females, while the osteoproliferative disease control group consisted of 14 males and 11 females, aged 35-70 years. The soft tissue injury treatment group consisted of 15 males and 10 females, while the osteoproliferative disease control group consisted of 14 males and 11 females, aged 35-70 years. There were no significant differences in gender, age, disease condition, or other general information between the two groups, making them comparable. The control group received local infrared irradiation, with 6 treatments constituting one course of treatment. The experimental group received the ointment of this invention (formula and preparation method in Example 2), with 6 treatments constituting one course of treatment.

[0024] The following grading standards were established: Marked effect: pain basically disappears and function is restored; Effective: pain is reduced and function is basically restored; Ineffective: symptoms do not improve after one course of treatment. The total effective rate is calculated as (marked effect + effective) / total number of cases × 100%.

[0025] The implementation team conducted the tests in the following manner: Apply the ointment evenly to the medicated paper, then apply it to the acupoint and fix it in place. Change it every 3 days. Use infrared irradiation on the affected area for 20 minutes / day. 6 times constitute one course of treatment. The evaluation cycle is 6 days. The test results are shown in Table 1.

[0026] Table 1: Evaluation Results of the Efficacy of Traditional Chinese Medicine Ointments in Treating Bone Hyperplasia and Soft Tissue Injury As can be seen from the table above, the total effective rate of the traditional Chinese medicine ointment disclosed in this invention for osteophyte formation is 92%, and the total effective rate for soft tissue injury is 92%. This indicates that the synergistic effect of Euphorbia pekinensis, Daphne genkwa, and Euphorbia kansui in the composition has a significant effect on softening osteophyte tissue and resolving local phlegm and blood stasis in osteophyte formation. It also has a prominent effect on relieving swelling and pain caused by hematoma organization and meridian blockage in soft tissue injury. Licorice has a significant effect on neutralizing the toxicity of all the medicinal materials in the formula, and seaweed enhances the effects of softening and dispersing nodules and reducing swelling. The overall combination has a definite curative effect and good safety.

[0027] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine ointment for treating bone hyperplasia and soft tissue injury, comprising raw materials and excipients, wherein the raw materials include Euphorbia pekinensis, Daphne genkwa, Euphorbia kansui, Glycyrrhiza uralensis, and Sargassum, and the excipients include oil and litharge.

2. The traditional Chinese medicine ointment for treating bone hyperplasia and soft tissue injury according to claim 1, characterized in that, The raw material comprises the following components in parts by weight: 30-60 parts of Euphorbia pekinensis, 20-35 parts of Daphne genkwa, 25-45 parts of Euphorbia kansui, 30-50 parts of Glycyrrhiza uralensis, and 30-50 parts of Sargassum.

3. The traditional Chinese medicine ointment for treating bone hyperplasia and soft tissue injury according to claim 2, characterized in that, The raw material comprises the following components in parts by weight: 35-50 parts of Euphorbia pekinensis, 25-30 parts of Daphne genkwa, 25-40 parts of Euphorbia kansui, 35-45 parts of Glycyrrhiza uralensis, and 35-45 parts of Sargassum.

4. The traditional Chinese medicine ointment for treating bone hyperplasia and soft tissue injury according to claim 3, characterized in that, The raw material comprises the following components in parts by weight: 40-50 parts of Euphorbia pekinensis, 26-39 parts of Daphne genkwa, 30-40 parts of Euphorbia kansui, 38-42 parts of Glycyrrhiza uralensis, and 38-42 parts of Sargassum.

5. A traditional Chinese medicine ointment for treating bone hyperplasia and soft tissue injury according to claim 4, characterized in that, The raw material comprises the following components in parts by weight: 45 parts of Euphorbia pekinensis, 28 parts of Daphne genkwa, 35 parts of Euphorbia kansui, 40 parts of Glycyrrhiza uralensis, and 40 parts of Sargassum.

6. A traditional Chinese medicine ointment for treating bone hyperplasia and soft tissue injury according to claim 5, characterized in that, The amount of oil used is 3-4 times the total weight of the raw materials, and the amount of litharge is 1 / 3 of the total amount of oil.

7. A traditional Chinese medicine ointment for treating bone hyperplasia and soft tissue injury according to claim 6, characterized in that, The oil is sesame oil or peanut oil.

8. A method for preparing a traditional Chinese medicine ointment as described in any one of claims 1-7, characterized in that, Includes the following steps: Step 1: Weigh each raw material according to the weight ratio, rinse with clean water to remove mud and impurities, place in a ventilated and cool place to air dry until the moisture content is ≤10%, and then use a Chinese medicine slicer to cut into thin slices of 2-5mm thickness for later use; Step 2: Place the pre-treated medicinal materials into a ceramic jar, add 3-4 times the total weight of the raw materials in sesame oil or peanut oil, seal the jar, soak for 12-18 days in spring and winter, and 8-12 days in summer and autumn, stirring every 2-3 days during the process to ensure that the medicinal materials are fully soaked; Step 3: Pour the soaked herbs and oil into an iron pot. First, simmer at 100-120℃ for 30-60 minutes, stirring constantly to prevent the herbs from sticking to the pot, until the red euphorbia, kansui, and licorice turn light yellow, indicating that the active ingredients have begun to be extracted. Then, continue to simmer at 150-180℃ until the herbs turn dark black and become brittle. Turn off the heat and let it cool to room temperature. Filter the oil through an 80-mesh stainless steel filter, collect the filtered oil, and discard the dregs. Step 4: Pour the collected medicinal oil back into the pot and heat it at a temperature of ≥100℃ until the oil forms beads when dripped into water. Turn off the heat and let it cool naturally for 5-8 minutes. Add litharge (1 / 3 of the total weight of the medicinal oil) and stir quickly clockwise for 20-30 minutes to ensure that the litharge and medicinal oil are fully mixed. Immediately pour the ointment into cold water while it is still hot and soak it for 24 hours, changing the cold water 2-3 times during this period to remove the fire toxicity and residual toxicity from the ointment. Remove it and drain the water to obtain the finished black plaster.

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