A polysaccharide active in sargassum and a preparation method and application thereof

By extracting and isolating PEP-W-1, an active polysaccharide from jicama, the problem of gut microbiota regulation in liver fibrosis was solved, achieving protection and regulation of liver fibrosis and showing a significant anti-fibrotic effect.

CN121824798BActive Publication Date: 2026-06-09THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
Filing Date
2026-03-12
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

The occurrence and development of liver fibrosis are influenced by a variety of factors. Current technologies are insufficient to effectively regulate the gut microbiota, leading to liver dysfunction and fibrosis progression. There is a lack of effective prevention and treatment strategies.

Method used

Active polysaccharides of jicama were extracted and isolated from jicama beans, and prepared into active polysaccharide PEP-W-1 through steps such as thermal extraction, alcohol precipitation, ion exchange chromatography and gel filtration. It is intended for use in regulating the intestinal microbiota and is a potential anti-liver fibrosis drug.

Benefits of technology

PEP-W-1, an active polysaccharide from jicama, showed a protective effect on the liver in a mouse model of liver fibrosis induced by bile duct ligation, regulating the gut microbiota, alleviating liver fibrosis, improving liver function indicators, and reducing the expression of fibrosis markers.

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Abstract

This invention relates to the field of active polysaccharide technology, specifically to a jicama active polysaccharide, its preparation method, and its applications. The jicama active polysaccharide of this invention exhibits characteristic absorption peaks in its infrared spectrum at at least the following positions: 3317 cm⁻¹, 2911 cm⁻¹, and 1404 cm⁻¹. ‑1 1021cm ‑1 And 642cm⁻¹. This invention extracts and isolates polysaccharides from japonica beans. These polysaccharides have a protective effect in a mouse model of liver fibrosis induced by bile duct ligation and also have a regulatory effect on the intestinal microbiota, thus exerting anti-fibrotic activity.
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