Blood sample mixing device and blood analyzer
By driving the mixing component to perform elliptical reciprocating motion through an eccentric rotation mechanism, combined with the collision of the inner and outer walls of the test tube, the problem of poor blood mixing effect in long conical test tubes is solved, and efficient blood sample mixing is achieved.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- DIRUI MEDICAL TECH CO LTD
- Filing Date
- 2025-12-26
- Publication Date
- 2026-04-10
AI Technical Summary
Existing blood sample mixing devices have poor mixing effect on the terminal blood collection tube at the bottom of the inner cavity of the long conical test tube. The vibration amplitude and centrifugal force during vibration/swing are insufficient, resulting in poor mixing effect.
An eccentric rotation mechanism drives the mixing component to perform elliptical reciprocating motion. The insertion rod is inserted into the hollow structure at the bottom of the test tube. Combined with the shape of the mixing cavity opening and the collision with the outer wall of the test tube, a composite vibration mode is formed, which promotes the rolling and mixing of blood.
It significantly improves the mixing efficiency of blood in a long conical test tube. Through the synergistic action of the internal insertion rod and the external cavity, the blood is tumbled up and down, ensuring a good mixing effect.
Smart Images
Figure CN121830221A_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The application relates to the technical field of in-vitro detection, in particular to a blood sample mixing device and a blood analyzer. BACKGROUND
[0002] A commonly used method for mixing trace blood in a peripheral tube is to shake or swing the bottom of the test tube to achieve the effect of mixing blood. When a peripheral blood collection tube with a long conical inner cavity and a cavity bottom located in the upper part of the tube is used, the blood is far away from the bottom of the tube, and the vibration amplitude and centrifugal force received by the blood are weak during vibration / shaking, so the mixing effect is poor.
[0003] Therefore, the prior art still needs to be improved. SUMMARY
[0004] The application aims to provide a blood sample mixing device to solve the problem of poor mixing effect of the prior art.
[0005] To achieve the above-mentioned purpose, the technical scheme adopted by the embodiments of the application is as follows: A blood sample mixing device, comprising: a base and a substrate fixed on the base; the substrate is provided with a power mechanism, an eccentric rotating mechanism and a mixing cavity with a hollow cavity structure; The eccentric rotating mechanism comprises an eccentric shaft and a mixing element, the lower end of the eccentric shaft is fixed on the substrate through a bearing, and the upper end is rotatably connected to a connecting piece through a bearing, the other end of the connecting piece is fixed with an adapter shaft; The substrate is also provided with a U-shaped groove, and the adapter shaft end fixed bearing and the U-shaped groove form a sliding connection; The eccentric shaft is driven to rotate by the power mechanism, and cooperates with the sliding of the adapter shaft in the U-shaped groove to drive the mixing element to make an elliptical reciprocating motion; The mixing element is fixed on the connecting piece, and the upper part of the mixing element is provided with an insertion rod for inserting into the hollow structure of the bottom of the test tube; when the test tube is placed in the mixing cavity, the insertion rod is located in the hollow structure of the bottom of the test tube, and the insertion rod collides with the inner wall of the test tube through the elliptical reciprocating motion.
[0006] The following is a preferred technical scheme of the application, but not as a limitation on the technical scheme provided by the application. Through the following preferred technical scheme, the purpose and beneficial effects of the application can be better achieved and realized.
[0007] As a preferred technical solution, the blood sample mixing device includes a base on which a positioning support for supporting the bottom of a test tube is provided, and an insertion rod is disposed on the positioning support; in the initial state, the bottom of the test tube is on the support.
[0008] As a preferred technical solution, in the blood sample mixing device, the sidewall of the positioning platform is an oblique conical surface that gradually increases in size in the outer radial direction.
[0009] As a preferred technical solution, in the blood sample mixing device, the opening of the mixing chamber is elliptical, and the shape of the elliptical opening matches the elliptical motion trajectory of the mixing component, so as to collide with the outer wall of the test tube during the mixing process.
[0010] As a preferred technical solution, in the blood sample mixing device, in the initial state, the center of the positioning platform coincides with the center of the opening of the mixing chamber; the insertion rod is disposed at the center of the positioning platform.
[0011] As a preferred technical solution, in the blood sample mixing device, the opening of the mixing chamber is a closed curved shape, and the edge of the opening is used to limit the movement range of the test tube.
[0012] As a preferred technical solution, the blood sample mixing device further includes a zero-point positioning mechanism, which is disposed on the side of the substrate away from the mixing cavity and corresponds to the position of the eccentric shaft.
[0013] As a preferred technical solution, the blood sample mixing device includes a zero-point positioning mechanism comprising a zero-position optical coupler and an optical coupler baffle mounted on an eccentric shaft and adapted to the zero-position optical coupler.
[0014] As a preferred technical solution, in the blood sample mixing device, the insertion rod is made of a non-metallic material.
[0015] In a second aspect, a blood analyzer includes: a transfer and loading gripper and the blood sample mixing device described above.
[0016] Thirdly, a method for mixing blood samples based on the aforementioned blood analyzer, wherein the method includes: Reset the sample mixing device; Test tubes are obtained using transfer loading grippers, and the type of test tube is identified; if it is determined to be a terminal tube, the terminal tube is placed in the mixing chamber. Alternate between forward and reverse rotation operations. After each cycle of forward and reverse rotation operations is completed, determine whether the current number of cycles has reached the preset number of cycles. When the number of cycles has reached the preset number of cycles, the flow ends; otherwise, return to continue to execute the next round of forward rotation and reverse rotation until the preset number of cycles is reached.
[0017] The blood sample mixing device provided by the application has at least the following beneficial effects: The blood vibration is realized by driving the mixing element to move in a reciprocating elliptical trajectory through the eccentric shaft, and on the other hand, the mixing element moves in an elliptical trajectory, so that the centrifugal force is generated by the rotation of the test tube to realize the internal blood climbing. The inner cavity of the test tube is collided by the mixing element, and the outer wall of the test tube is collided by the mixing cavity opening, so that the blood climbing due to the centrifugal force in the inner cavity does not continuously rise and falls to realize the up-down tumbling vibration mixing. BRIEF DESCRIPTION OF DRAWINGS
[0018] In order to more clearly illustrate the technical solutions in the embodiments of the application, the following will briefly introduce the drawings needed to be used in the embodiments or prior art description. Obviously, the drawings in the following description are only some embodiments of the application, and other drawings can be obtained by those skilled in the art without creative labor.
[0019] Figure 1 A perspective view of a blood sample mixing device provided by the embodiment of the application.
[0020] Figure 2 A sectional view of a blood sample mixing device provided by the embodiment of the application.
[0021] Figure 3 A sectional view of a mixing element provided by the embodiment of the application.
[0022] Figure 4 A top view of a mixing element provided by the embodiment of the application.
[0023] Figure 5 A top view of a mixing cavity and a mixing element provided by the embodiment of the application.
[0024] Figure 6 A perspective view of a blood analyzer provided by the embodiment of the application.
[0025] Figure 7 A perspective view of a blood analyzer provided by the embodiment of the application. Figure 6 An enlarged view of part A.
[0026] Figure 8 A test tube rotation movement process provided by the embodiment of the application, wherein a-transport device jaw initial position, b-sample rack test tube grabbing position, c-test tube type identification position, d-peripheral tube mixing cavity above, e-peripheral tube mixing position.
[0027] Figure 9A test tube mixing action process provided by the embodiment of the present application. DETAILED DESCRIPTION
[0028] In order to make the technical problems, technical solutions and beneficial effects of the present application clearer, the present application will be further described in detail below in combination with the drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and not to limit the present application.
[0029] It should be noted that when a component is referred to as "fixed to" or "disposed on" another component, it can be directly or indirectly on the other component. When a component is referred to as "connected to" another component, it can be directly or indirectly connected to the other component. The terms "upper", "lower", "left", "right", "front", "back", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate the orientation or position based on the orientation or position shown in the drawings, and are only for the convenience of description, and cannot be understood as a limitation on the technical solutions. The terms "first", "second" are only for the purpose of convenient description, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features. The meaning of "a plurality of" is two or more, unless otherwise specifically limited.
[0030] As shown in Figure 1 and Figure 2 The present embodiment provides a blood sample mixing device, which comprises a base 10 and a base plate 20 fixed on the base 10. The base plate 20 is the support framework of the entire device, on which a power mechanism 200, an eccentric rotating mechanism 210 and a mixing cavity 220 with a hollow cavity structure are installed. The power mechanism 200 can be a DC motor or a stepping motor, which is used to provide rotating power. The eccentric rotating mechanism mainly consists of an eccentric shaft 211 and a mixing element 212. Specifically, the lower end of the eccentric shaft 211 is installed on the base plate 20 through a bearing (the eccentric shaft end is also provided with a belt pulley 203), and is connected with the output end of the power mechanism 200 through a belt 201. The upper end of the eccentric shaft 211 has an eccentric part, which is rotatably connected to one end of a connecting piece 230 through a bearing 202. The mixing cavity 220 is fixed on the base plate 20 through a cavity seat fixing plate 204 In order to convert the simple rotating motion into a specific elliptical reciprocating motion, the other end of the connecting piece 230 is fixed with an adapter shaft 240. Correspondingly, a U-shaped groove (not shown) is provided on the base plate 20. The end of the adapter shaft 240 is fixed with a bearing, which is placed in the U-shaped groove and forms a sliding connection with the U-shaped groove.
[0031] When the power mechanism 200 drives the eccentric shaft 211 to rotate, one end of the connecting piece 230 follows the eccentric shaft to make a circular motion, and the other end is limited by the adapter shaft 240 and the U-shaped groove, and can only move back and forth in a straight line in the extension direction of the U-shaped groove. This mechanism (a variant of the crank slider mechanism) makes the mixing element 260 fixed in the middle of the connecting piece 230 generate an elliptical reciprocating motion track. This track, compared with simple circular motion or straight-line reciprocating motion, can generate more complex multidirectional acceleration, which is beneficial to the rolling of blood.
[0032] As shown in Figure 1 and Figure 2 , the mixing element 260 is fixed on the connecting piece 230, and the upper part of the mixing element 260 extends into the inside of the mixing cavity 220. The mixing cavity 220 has a space to accommodate the test tube 270. When the test tube 270 (especially the tip tube with a hollow structure at the bottom) is placed into the mixing cavity 220, the bottom of the test tube 270 is in contact with the mixing element 260.
[0033] As shown in Figure 3 and Figure 4 , the specific structure of the mixing element 260 includes a base 2600, which is provided with a positioning abutment 2601, and an insertion rod 2602 is upwardly extended at the center of the abutment 2601. The side wall of the positioning abutment 2601 is designed as a tapered surface 2603.
[0034] The insertion rod 2602 is preferably made of non-metallic material (such as wear-resistant plastic or rubber) to reduce noise and damage risk when colliding with the test tube. The diameter of the insertion rod 2602 is designed to be smaller than the inner diameter of the hollow hole at the bottom of the test tube 270, so that it can be inserted into it.
[0035] The working principle and process of the device are as follows: In the initial state, the test tube 270 is placed into the mixing cavity 220. Due to the action of gravity, the outer wall of the bottom of the test tube 270 abuts against the positioning abutment 2601 of the mixing element 260. At this time, the insertion rod 2602 is inserted into the hollow recess at the bottom of the test tube 270. The design of the tapered surface 2603 enables the test tube 270 to be naturally centered and kept upright, facilitating the grabbing or placing by the external mechanical hand.
[0036] When mixing is needed, the power mechanism 200 is started to drive the mixing element 260 to perform high-speed elliptical reciprocating motion.
[0037] Firstly, the insertion rod 2602 moves in the hollow cavity at the bottom of the test tube 270, directly colliding with the inner side wall of the test tube 270. Since the test tube 270 is usually long conical, and the blood is located in the upper part of the test tube, this "internal insertion type" vibration source is closer to the blood area than the traditional bottom tray vibration, and the energy transmission is more direct.
[0038] Secondly, as the vibration starts, the test tube 270 will climb up the inclined conical surface 2603 due to the centrifugal force and the impact force, and will be separated from the bottom surface of the support platform 2601, and will be in a "suspended" rolling state.
[0039] As shown in Figure 1 and Figure 5 , the top of the mixing cavity 220 is provided with a cavity opening 2200. In the embodiment, the cavity opening 2200 is designed as an ellipse, and the ellipse shape corresponds to the elliptical movement track of the mixing member 260 (i.e. the long axis direction is consistent). When the test tube 270 is driven to move by the mixing member 260, the upper part or the middle part of the test tube 270 will periodically collide with the inner wall of the cavity opening 2200.
[0040] This design forms a composite vibration mode: the inner insertion rod 2602 impacts the test tube outward, and the outer cavity opening 2200 limits the test tube inward. This high-frequency reciprocating impact forces the blood in the test tube to be unable to simply climb the wall due to the centrifugal force, but is forced to fall back and generate strong up-and-down rolling turbulence, thereby achieving excellent mixing effect.
[0041] In another embodiment, the cavity opening 2200 of the mixing cavity 220 can also be circular, as long as the outer diameter of the cavity opening 2200 is greater than the outer diameter of the test tube 270, and the gap is moderate, which can allow the test tube to shake and collide and limit a certain amplitude.
[0042] In the embodiment, the height direction of the cavity opening 2200 of the mixing cavity 220 is preferentially designed at the position near the bottom of the lumen of the test tube, as shown in Figure 1 , which can directly collide and vibrate the blood in the lumen. In order to reduce the collision noise, the mixing cavity 220 and the insertion rod 2602 preferentially adopt non-metallic materials, or the mixing cavity opening is inlaid with non-metallic materials.
[0043] In order to ensure that the test tube can be accurately reset after mixing to facilitate automatic grabbing, the device also includes a zero-point positioning mechanism 30. As shown in Figure 1 , the zero-point positioning mechanism 30 is arranged on the lower surface of the base plate 20 away from the mixing cavity 220, and is opposite to the lower end of the eccentric shaft 211. Specifically, the zero-point positioning mechanism 30 includes a zero-position optical coupler 300 fixed on the base plate and an optical coupler blocking piece 301 fixed on the eccentric shaft or the connecting piece.
[0044] When the mixing is completed, the control system detects the zero position optocoupler signal to control the power mechanism 200 to stop at a specific position. In this "zero position" state, the center of the support platform 2601 of the mixing element 260 is located on the center axis of the mixing cavity 220 (i.e., the center of the support platform coincides with the center of the cavity mouth of the mixing cavity). At this time, with the vibration stopped, the test tube 270 slides along the inclined conical surface 2603 under the action of gravity, automatically falls to the bottom of the support platform 2601 and restores the upright state, completing the automatic positioning and waiting for the next operation. By controlling the motor step number, the initial position of the mixing rod can be reset to ensure that the initial position is fixed when the clamping jaw clamps the tube each time.
[0045] Exemplarily, in combination with Figure 5 , the test tube is in an upright state, the radius of the insertion rod 2602 is d, the eccentric distance of the positioning support platform 2601 relative to the insertion rod 2602 is L, the radius of the inner cavity 2702 at the bottom of the test tube is r, the radius of the outer wall 2701 of the test tube is R, and the short axis of the oval mouth is b, which need to satisfy: d+L≤r, b≥R, and in the embodiment, b=R+0.5.
[0046] As shown in Figures 7 to 8 , based on the same inventive concept, the present application also provides a blood analyzer, which comprises a transfer loading clamping jaw 188, a tube grasping and lifting process sensor 196 and the blood sample mixing device described above. The test tube transfer motion process can refer to Figure 7 . The transfer loading clamping jaw 188 can advance to grasp the test tube 270 on the sample rack 147, the tube grasping and lifting process sensor 196 identifies the type of test tube, such as judging as a peripheral tube, the clamping jaw 188 retreats above the mixing cavity mouth 2200 of the sample mixing device, the clamping jaw lowers to place the tube, and after the mixing of the peripheral tube is completed, the clamping jaw 188 grasps the test tube back to the sample rack 147.
[0047] As shown in Figure 9 , the test tube mixing motion process in the present application comprises: first performing "sample mixing device reset", and then "transfer device tube placement". Then, the system enters a cycle: first performing "mixing device forward rotation number" and pausing, and then performing "mixing device reverse rotation number" and pausing. After each complete set of forward rotation and reverse rotation operation, the system will judge whether the current cycle number has reached the preset "cycle number". If not, return to continue the next round of forward rotation and reverse rotation; if yes, the process is ended. This design ensures that the mixing process is repeated within a specified number of cycles until all operations are completed.
[0048] In summary, the application provides a blood sample mixing device, comprising: a base and a substrate fixed on the base; the substrate is provided with a power mechanism, an eccentric rotating mechanism and a mixing cavity with a hollow cavity structure; the eccentric rotating mechanism comprises an eccentric shaft and a mixing element, the lower end of the eccentric shaft is fixed on the substrate through a bearing, and the upper end is rotatably connected to a connecting piece through a bearing, the other end of the connecting piece is fixed with an adapter shaft; the substrate is also provided with a U-shaped groove, and the end bearing of the adapter shaft is in sliding connection with the U-shaped groove; the eccentric shaft is driven to rotate by the power mechanism, and cooperates with the sliding of the adapter shaft in the U-shaped groove to drive the mixing element to make an elliptical reciprocating motion; the mixing element is fixed on the connecting piece, and the upper part of the mixing element is provided with an insertion rod for inserting into the hollow structure at the bottom of the test tube; when the test tube is placed in the mixing cavity, the insertion rod is located in the hollow structure at the bottom of the test tube, and the elliptical reciprocating motion of the insertion rod collides with the inner wall of the test tube.
[0049] The application inserts the mixing element (insertion rod) into the hollow structure at the bottom of the test tube, and drives it to make an elliptical reciprocating motion, so that the vibration source directly acts on the inner wall of the test tube, greatly shortens the vibration transmission path, and significantly improves the mixing efficiency of the long conical test tube with the middle and upper cavity bottom. The elliptical reciprocating motion of the mixing element cooperates with the shape of the mixing cavity opening, so that the test tube is subjected to the synergistic effect of internal mixing rod collision and external cavity opening collision during the mixing process, which promotes the blood to form up and down rolling, and solves the problem that the upper blood cannot be effectively disturbed by simply relying on the bottom drive. The positioning bearing and inclined conical surface structure designed on the mixing element realize the integration function of "positioning-mixing-reset". In the initial state, the bearing supports the test tube to stand upright, which is convenient for mechanical grabbing; after the mixing is completed, the test tube can automatically slide and reset through the inclined conical surface, which cooperates with the zero positioning mechanism to ensure the smoothness of the automatic process.
[0050] The above only describes the preferred embodiments of the application and is not intended to limit the application. Any modifications, equivalent replacements and improvements made within the spirit and principles of the application shall be included in the protection scope of the application.
Claims
1. A blood sample mixing device, characterized in that, include: A base and a substrate fixed on the base; the substrate is provided with a power mechanism, an eccentric rotation mechanism and a mixing chamber with a hollow cavity structure. The eccentric rotation mechanism includes an eccentric shaft and a mixing component. The lower end of the eccentric shaft is fixed to the base plate by a bearing, and the upper end is rotatably connected to the connecting component by a bearing. The other end of the connecting component is fixed to the adapter shaft. The substrate is also provided with a U-shaped groove, and the end bearing of the adapter shaft is slidably connected to the U-shaped groove; The eccentric shaft is driven to rotate by the power mechanism, and the sliding of the adapter shaft in the U-shaped groove drives the mixing component to perform elliptical reciprocating motion. The mixing component is fixed to the connector, and the upper part of the mixing component is provided with an insertion rod for inserting into the hollow structure at the bottom of the test tube; when the test tube is placed in the mixing chamber, the insertion rod is located in the hollow structure at the bottom of the test tube, and the elliptical reciprocating motion of the insertion rod collides with the inner wall of the test tube.
2. The blood sample mixing device as described in claim 1, characterized in that, The mixing component includes a base on which a positioning support is provided for supporting the bottom of the test tube, and the insertion rod is disposed on the positioning support; in the initial state, the bottom of the test tube is on the support.
3. The blood sample mixing device as described in claim 2, characterized in that, The sidewall of the positioning platform is an oblique conical surface that gradually increases in size from the outer radial direction upwards.
4. The blood sample mixing device as described in claim 2, characterized in that, The opening of the mixing chamber is elliptical, and the shape of the elliptical opening matches the elliptical motion trajectory of the mixing component, so as to collide with the outer wall of the test tube during the mixing process.
5. The blood sample mixing device as described in claim 2, characterized in that, In the initial state, the center of the positioning platform coincides with the center of the opening of the mixing chamber; the insertion rod is located at the center of the positioning platform.
6. The blood sample mixing apparatus as described in claim 1, characterized in that, The mixing chamber has a closed curved opening, and the edge of the opening is used to limit the movement range of the test tube.
7. The blood sample mixing apparatus as described in claim 1, characterized in that, The blood sample mixing device further includes a zero-point positioning mechanism, which is disposed on the side of the substrate away from the mixing chamber and corresponds to the position of the eccentric shaft.
8. The blood sample mixing apparatus as described in claim 7, characterized in that, The zero-point positioning mechanism includes: a zero-position optocoupler and an optocoupler baffle mounted on an eccentric shaft that is adapted to the zero-position optocoupler.
9. A blood analyzer, characterized in that, include: The transfer loading gripper and the blood sample mixing device described in any one of 1-8.
10. A method for mixing blood samples using a blood analyzer according to claim 9, characterized in that, include: Reset the sample mixing device; Test tubes are acquired using transfer loading grippers, and the type of test tube is identified. If it is determined to be a terminal tube, then the terminal tube is placed in the mixing chamber; Alternate between forward and reverse rotation operations. After each complete cycle of forward and reverse rotation operations, determine whether the current number of cycles has reached the preset number of cycles. The process ends when the preset number of iterations has been reached. Otherwise, return to the previous round of forward and reverse rotations until the preset number of cycles is reached.