Behavior analysis device and monitoring device

Abstract

The invention discloses a behavior analysis device and a monitoring device. The behavior analysis device comprises a constant-voltage power supply module; a conductive platform; the first conductive piece is connected with the high-potential end; the second conductive part is connected with the low-potential end and the conductive platform; a conductive layer is arranged at a first position of the insulating part, and the conductive layer is connected with the first conductive part; the conducting layer can be in contact with an animal at the first position, and when the animal is in contact with the conducting layer, a loop is formed between the high-potential end and the low-potential end, and an electric signal is generated and used for representing behaviors of the animal; the sampling module is used for collecting an electric signal of a first duration and generating a monitoring result based on the collected electric signal; the electric signal comprises a current signal and / or a voltage signal of the loop; and the analysis module is used for acquiring the monitoring result and analyzing the electric signal in the monitoring result to determine a behavioral index. According to the behavior analysis device, manual participation is not needed when the monitoring result is determined, and the obtained monitoring result is relatively objective, high in accuracy and high in efficiency.

Description

Technical Field

[0001] This invention relates to the field of oral pain model analysis technology, specifically to a behavioral analysis device and a monitoring device. Background Technology

[0002] Oral and facial pain is one of the most common types of pain worldwide. In order to study the pain mechanism and screen analgesic drugs, it is necessary to establish an animal-based oral pain model, determine the animal's behavioral indicators through the oral pain model, and study the pain mechanism and screen analgesic drugs based on the animal's behavioral indicators.

[0003] Currently, the determination of animal behavioral indicators involves monitoring animal behavior and analyzing the monitoring results. In this method, the monitoring results are determined by combining video recording and manual counting. The behavioral indicators are then analyzed. However, this method is highly subjective, inefficient, and prone to errors. Summary of the Invention

[0004] The main technical problem solved by this invention is that the method of determining monitoring results by combining video recording with manual counting and then analyzing the monitoring results to obtain animal behavioral indicators is highly subjective, inefficient, and prone to errors.

[0005] One embodiment of this application provides a behavior analysis device for determining behavioral indicators of animals, the behavior analysis device comprising:

[0006] A constant voltage power supply module includes a high potential terminal and a low potential terminal, and the constant voltage power supply module is used to form a constant supply voltage between the high potential terminal and the low potential terminal;

[0007] A conductive platform for supporting the animal and for grounding;

[0008] A first conductive element is connected to the high-potential terminal;

[0009] The second conductive element connects the low-potential terminal and the conductive platform;

[0010] An insulating component is provided for wearing on the body of the animal. A conductive layer is provided at a first position of the insulating component, and the conductive layer is connected to the first conductive component. The conductive layer can contact the animal at the first position, and when the animal contacts the conductive layer, a circuit is formed between the high potential end and the low potential end, and an electrical signal is generated. The electrical signal is used to characterize the behavior of the animal.

[0011] A sampling module is used to acquire electrical signals for a first duration and generate monitoring results based on the acquired electrical signals; the electrical signals include current signals and / or voltage signals of the circuit;

[0012] An analysis module is used to acquire the monitoring results and analyze the electrical signals in the monitoring results to determine the behavioral indicators.

[0013] In one embodiment, the insulating element includes an insulating collar for wearing on the neck of the animal, the first position being disposed on the insulating collar.

[0014] In one embodiment, the insulating collar is a frustum-shaped collar.

[0015] In one embodiment, the insulating collar is made of resin or a glass fiber reinforced epoxy resin composite substrate.

[0016] In one embodiment, the first position is located on the outer ring of the insulating collar.

[0017] In one embodiment, the behavior analysis device further includes: a voltage divider module and a third conductive element;

[0018] The third conductive component connects the high-potential terminal and the voltage divider module;

[0019] The first conductive element connects the voltage divider module and the conductive layer.

[0020] In one embodiment, the animal is a mouse; the mouse is able to come into contact with the conductive layer when it rubs or scratches its face with its limbs.

[0021] In one embodiment, the filtering and analysis of the data in the monitoring results to obtain the behavioral indicators includes:

[0022] Remove signals from the monitoring results whose peak electrical signal value is less than a first preset threshold;

[0023] The retained signals are grouped. Two adjacent electrical signals with a time interval less than or equal to a second preset threshold belong to the same signal group. For two adjacent electrical signals with a time interval greater than the second preset threshold, the first electrical signal is taken as the end point of the current signal group, and the second electrical signal is taken as the start point of the new signal group.

[0024] Remove signal groups whose duration between the start and end points is less than a third preset threshold, and signal groups whose peak value is greater than a fourth preset threshold;

[0025] Determine the total number of signal groups to be retained, the duration between the start point signal of the first signal group and the end point signal of the last signal group in the retained signal groups, and the integral area of ​​each signal group in the retained signal groups relative to the baseline;

[0026] The animal's behavioral indicators are determined based at least on the total number, the total duration, and the area of ​​each integral, in order to analyze the animal's oral pain model.

[0027] In one embodiment, determining the animal's behavioral indicators based at least on the total number, the total duration, and each integral area includes:

[0028] Determine the number of signal groups in the retained signal groups per unit time;

[0029] Determine the ratio of the total duration to the total number;

[0030] The behavioral index is determined based on the total number, the total duration, the area of ​​each integral, the number of signal groups in the retained signal group per unit time, and the ratio.

[0031] According to a second aspect, one embodiment of this application provides a behavior monitoring device for determining behavioral indicators of an animal, the behavior monitoring device comprising:

[0032] A constant voltage power supply module includes a high potential terminal and a low potential terminal, and the constant voltage power supply module is used to form a constant supply voltage between the high potential terminal and the low potential terminal;

[0033] A conductive platform for supporting animals and for grounding;

[0034] A first conductive element is connected to the high-potential terminal;

[0035] The second conductive element connects the low-potential terminal and the conductive platform;

[0036] An insulating component is used to be worn on the body of the animal. A conductive layer is provided at a first position of the insulating component, and the conductive layer is connected to the first conductive component. The conductive layer can contact the animal at the first position, and when the animal contacts the conductive layer, a circuit is formed between the high potential end and the low potential end, and an electrical signal is generated.

[0037] A sampling module is used to acquire electrical signals for a first duration and generate monitoring results based on the acquired electrical signals; the electrical signals include current signals and / or voltage signals of the circuit; the monitoring results are used to analyze the behavioral indicators of the animal.

[0038] According to the behavior analysis device and monitoring device of the above embodiments, since the animal can contact the conductive layer at the first position to form a circuit between the high-potential end and the low-potential end, when determining animal behavioral indicators, the first position can be set at a position where the animal can contact the conductive layer when performing the behavior to be monitored, and separate from the conductive layer when not performing the behavior to be monitored. Thus, animal behavior can be monitored by collecting electrical signals in the circuit. When determining the monitoring results, electrical signals of a first duration can be collected to form monitoring results, and behavioral indicators can be determined based on these monitoring results. Compared to the method of combining video recording and manual counting, this behavior analysis device does not require human intervention when determining monitoring results, and the obtained monitoring results are more objective, accurate, and efficient. Attached Figure Description

[0039] Figure 1 This is a schematic diagram of the connection of the behavior monitoring device in one embodiment;

[0040] Figure 2 This is a waveform diagram of the monitoring results in one embodiment.

[0041] Reference numerals: 100, animal; 201, insulating component; 202, conductive platform; 203, first conductive component; 204, second conductive component; 205, third conductive component; 206, power consumption analyzer; 207, voltage divider module. Detailed Implementation

[0042] The present invention will now be described in further detail with reference to specific embodiments and accompanying drawings. Similar elements in different embodiments are referred to by associated similar element reference numerals. In the following embodiments, many details are described to facilitate a better understanding of this application. However, those skilled in the art will readily recognize that some features may be omitted in different situations, or may be replaced by other elements, materials, or methods. In some cases, certain operations related to this application are not shown or described in the specification. This is to avoid obscuring the core parts of this application with excessive description. For those skilled in the art, detailed description of these related operations is not necessary; they can fully understand the related operations based on the description in the specification and general technical knowledge in the art.

[0043] Furthermore, the features, operations, or characteristics described in the specification can be combined in any suitable manner to form various embodiments. At the same time, the steps or actions in the method description can be rearranged or adjusted in a manner obvious to those skilled in the art. Therefore, the various orders in the specification and drawings are only for the clear description of a particular embodiment and do not imply a necessary order, unless otherwise stated that a particular order must be followed.

[0044] The serial numbers assigned to components in this document, such as "first" and "second," are used only to distinguish the described objects and have no sequential or technical meaning. Unless otherwise specified, the terms "connection" and "linkage" used in this application include both direct and indirect connections (linkages).

[0045] Orofacial pain is a complex pain condition involving the oral cavity, face, and mandibular region, including toothache, temporomandibular joint disorder (TMD), and trigeminal neuralgia. It is one of the most common pain complaints in clinical practice, significantly impacting patients' quality of life. Epidemiological studies indicate that orofacial pain is one of the most prevalent types of pain globally, with an actual prevalence of approximately 25%, of which about 10% is chronic orofacial pain (COFP). Chronic orofacial pain is associated with significant morbidity, psychological burden, and high utilization of medical resources. In basic medical and pharmacological research, due to the highly complex neural mechanisms of orofacial pain (primarily involving the trigeminal nerve system), establishing stable and quantifiable animal models is crucial for studying pain mechanisms and screening analgesic drugs.

[0046] To study pain mechanisms and screen analgesics, it is necessary to establish animal-based oral pain models. These models determine behavioral indicators in the animals, which are then used to investigate pain mechanisms and screen analgesics. In oral pain models, pain assessment is highly dependent on observable and recordable animal behavior. In mice, the most typical and specific pain-related behaviors for oral and facial pain involve repeated scratching or rubbing of the stimulated facial area with the forepaws or hind paws. Therefore, objectively and accurately quantifying this subtle facial contact behavior is a core technical challenge in the field of pain research.

[0047] To induce and study this behavior, injecting formalin solution into the face of mice is a classic method for inducing inflammatory oral-facial pain. After injection into the oral region, mice exhibit significant pain-related behavioral responses, such as repeatedly scratching and touching their face with their forepaws. Current assessments of this facial pain response primarily rely on video recordings and manual counting, but these methods suffer from high subjectivity, low efficiency, and susceptibility to errors. Some studies have attempted to use computer vision for automated analysis, but this method is costly, complex, and struggles to define detection thresholds for such subtle facial behaviors. Furthermore, none of these methods can determine the intensity of the animal's face-touching.

[0048] Based on this, this application provides a behavioral analysis device for determining behavioral indicators of animal 100. For example... Figure 1As shown, the behavior analysis device may include a constant voltage power supply module, a conductive platform 202, a first conductive element 203, a second conductive element 204, an insulating element 201, a sampling module, and an analysis module. The constant voltage power supply module includes a high potential terminal and a low potential terminal (the high potential terminal is...). Figure 1 The "+" terminal in the diagram has a low potential. Figure 1 The "-" terminal (the low potential terminal can also be understood as the grounding terminal of the constant voltage power supply module) is used to form a constant supply voltage between the high potential terminal and the low potential terminal; the conductive platform 202 is used to support the animal 100 and ground; the first conductive element 203 is connected to the high potential terminal; the second conductive element 204 is connected to the low potential terminal and the conductive platform 202; the insulating element 201 is used to be worn on the body of the animal 100, and a conductive layer is provided at the first position of the insulating element 201, which is connected to the first conductive element 203; the conductive layer can contact the animal 100 at the first position, and when the animal 100 contacts the conductive layer, a circuit is formed between the high potential terminal and the low potential terminal, and an electrical signal is generated, which is used to characterize the behavior of the animal 100; the sampling module is used to collect electrical signals for a first duration and generate monitoring results based on the collected electrical signals; the electrical signals include the current signal and / or voltage signal of the circuit; the analysis module is used to obtain the monitoring results and filter and analyze the electrical signals in the monitoring results to determine behavioral indicators.

[0049] In some embodiments, the animal 100 may be a mouse. After the mouse is injected with formalin solution into its face, it exhibits a significant pain-related behavioral response, which is scratching or rubbing the stimulated facial area with its forepaws. The first position is set at a location where the mouse can contact the conductive layer when scratching or rubbing the stimulated facial area, but does not contact the conductive layer when not scratching or rubbing.

[0050] The first conductive element 203 can be a wire, one end of which is connected to a high-potential end and the other end of which is connected to a conductive layer on the insulating element 201. The second conductive element 204 can also be a wire, one end of which is connected to a low-potential end and the other end of which is connected to the conductive platform 202. The conductive platform 202 can be a metal plate, a metal mesh, a conductive plastic plate, or the bottom surface of a cage covered with a conductive mat, etc. In one specific embodiment, the conductive platform 202 is a square metal mesh, and the mouse is placed on the square metal mesh.

[0051] When setting the conductive layer, a metal foil or conductive cloth can be attached to the first position; conductive ink or conductive paint can be brushed onto the first position; or the conductive layer can be formed by nano sponges; those skilled in the art can determine the specific implementation method of the conductive layer according to the actual situation.

[0052] In practical applications, a constant voltage is output through a constant voltage power supply module, and formalin solution is injected into the face of a mouse. An electrical signal is collected for a first duration using a sampling module; specifically, the electrical signal is the current in the circuit, such as... Figure 2 The image shows the waveform of the current signal collected for the first duration. In this embodiment, when the mouse scratches or rubs its face, a circuit is formed between the high-potential and low-potential terminals, generating a current signal. When the mouse does not scratch or rub its face, the high-potential and low-potential terminals are disconnected, i.e., the circuit is open, and there is no current signal in the circuit. The current signal in the circuit can be collected by the sampling module, and the current signal sampled each time is recorded. After collecting the current signal for the first duration, the current signal for the first duration is used to form a monitoring result. This monitoring result is an exportable data file. This data file can be manually exported and copied to the analysis module. The analysis module analyzes this data file and finally determines the behavioral indicators of the mouse. The first duration can be determined by those skilled in the art based on the actual situation of the required data, and is not limited here.

[0053] In other words, the principle of this behavior analysis device is that when the mouse's paw (which has been grounded through the conductive platform 202) touches the conductive layer on the insulating component 201, the circuit is instantly closed, and the high potential end and the low potential end form a loop, thereby instantly and with high fidelity converting the physical behavior of the animal 100 into a recordable electrical signal. Compared with the method of combining video recording and manual counting, this behavior analysis device does not require human intervention when determining the monitoring results, and the monitoring results obtained are more objective, accurate and efficient.

[0054] Of course, the electrical signal can also be a voltage signal. After acquiring the voltage signal for the first duration, a monitoring result is formed. Alternatively, the acquired voltage signal can be converted into a current signal. The electrical signal can also be a combination of voltage and current signals. After acquiring both voltage and current signals for the first duration, a monitoring result is formed.

[0055] In some embodiments, the analysis module can be a terminal device such as a desktop computer or laptop. The following explanation uses a desktop computer as an example to illustrate the analysis of monitoring results. Analyzing the data in the monitoring results to obtain behavioral indicators includes the following steps:

[0056] S100: Remove signals whose peak electrical signal value is less than the first preset threshold from the monitoring results;

[0057] S200. The retained signals are grouped. Two adjacent electrical signals with a time interval less than or equal to the second preset threshold belong to the same signal group. The first electrical signal among two adjacent electrical signals with a time interval greater than the second preset threshold is taken as the end point of the current signal group, and the second electrical signal is taken as the start point of the new signal group.

[0058] S300: Remove signal groups whose duration between the start point signal and the end point signal is less than a third preset threshold, and signal groups whose peak value is greater than a fourth preset threshold.

[0059] S400, Determine the total number of signal groups to be retained, the duration between the start signal of the first signal group and the end signal of the last signal group in the retained signal groups, and the integral area of ​​each signal group in the retained signal groups relative to the baseline.

[0060] S500, determine at least 100 behavioral indicators for the animals based on the total number, total duration, and area of ​​each integral.

[0061] Specifically, the monitoring results are copied to a desktop computer, where they can be converted into a .csv data file. The results can then be analyzed using MATLAB software. Figure 2 The image shows the waveform of the current signal acquired for the first duration. During analysis, threshold denoising is performed first, that is, signals with current values ​​less than a first preset threshold are removed from the monitoring results. The first preset threshold can be 0.5 μA; of course, the first preset threshold can also be 0.6 μA, 0.7 μA, etc., and the specific value of the first preset threshold can be determined based on the specific noise signal. Alternatively, programs written in other software or programming languages ​​(such as C, Python, etc.) that implement the same algorithm logic (i.e., "threshold denoising," "time interval merging," and "shortest duration filtering") can also be used, without further limitations here.

[0062] After denoising, the retained signals are grouped. During grouping, a second preset threshold is set, which can be understood as a time threshold. Those skilled in the art can determine the specific value of the second preset threshold based on the actual situation. For example, the second preset threshold could be 0.5s; or it could be 0.6s, 0.75s, 0.8s, etc. Starting from the initial signal, the signals are divided sequentially. Two adjacent electrical signals with a time interval less than or equal to the second preset threshold are grouped into the same signal group. For two adjacent electrical signals with a time interval greater than the second preset threshold, the preceding electrical signal is taken as the end point of the current signal group, and the following electrical signal is taken as the start point of a new signal group. In other words, starting from the initial signal (referring to the initial signal in the entire monitoring result), each time a time interval greater than the second preset threshold occurs, it can be understood that a dividing point is set between the two adjacent electrical signals corresponding to that time interval. The electrical signals before the first dividing point belong to the same signal group, and then the electrical signals between every two adjacent dividing points are grouped into the same signal group. This method divides the retained electrical signals into multiple signal groups.

[0063] Among all signal groups, some may be spurious signals. To improve the accuracy of the behavioral indicators obtained from the analysis, these spurious signals are further processed. A spurious signal refers to a signal group whose duration is less than a third preset threshold or whose peak value is greater than a fourth preset threshold. In other words, among the retained signal groups, a signal group will be removed if the total duration from the start signal to the end signal is less than the third preset threshold, and if the peak value of the signal group is greater than the fourth preset threshold. The third preset threshold can be 0.1s; however, it can also be 0.15s, 0.2s, etc., and the specific value of the third preset threshold can be determined according to the specific grouping situation.

[0064] The fourth preset threshold can be 2μA, 2.5μA, 3.1μA, 3.5μA, etc., and the specific value of the fourth preset threshold can be determined by the art according to the specific grouping situation.

[0065] After spur signal removal, determine the number of signal groups that are ultimately retained, the duration between the start point signal of the first signal group and the end point signal of the last signal group, and the integral area of ​​each signal group in the retained signal groups relative to the baseline; determine at least 100 behavioral indicators of the animal based on the total number, total duration, and each integral area.

[0066] In some embodiments, the number of signal groups in a signal group retained per unit time is determined by a desktop computer; the ratio between the total duration and the total number is further calculated; and finally, behavioral indicators are determined based on the total number, total duration, area of ​​each integral, number of signal groups in a signal group retained per unit time, and the ratio.

[0067] The unit of time can be 1 second or 5 seconds, and those skilled in the art can define the unit of time according to the actual situation.

[0068] In some embodiments, each integral area represents the intensity of a face-touching action. The integral area can be calculated using the trapezoidal integral method, or other integration methods such as Simpson's method or rectangular summation. Compared to traditional methods (such as video recording and manual counting, automatic analysis using computer vision recognition, etc.), this behavioral analysis device can reflect the intensity of a mouse's face-touching action during pain based on the integral area of ​​each signal group, enabling more accurate analysis of oral pain models.

[0069] In some embodiments, the insulating element 201 may be, but is not limited to, an insulating collar, which is worn around the neck of the animal 100, with the first position located on the outer ring of the insulating collar. The insulating collar may be made of resin or a glass fiber reinforced epoxy resin composite substrate. Those skilled in the art can determine the specific material of the insulating collar according to actual needs, and no further limitations are imposed here.

[0070] In some embodiments, the first position is located on the outer ring of the insulating collar, facing the mouse's head. It is necessary to ensure that the area where the insulating collar contacts the conductive platform 202 when the mouse lowers its head is an insulating region to avoid accidental short circuits. Furthermore, when a conductive layer is provided on the insulating collar, the conductive layer does not cover the entire outer ring of the insulating collar, but rather adopts a regional coverage design to improve the specificity of detection and prevent false triggering. Specifically, the conductive layer can be located in the distal region of the outer ring of the insulating collar (i.e., the end away from the animal's neck). Assuming the radial width of the insulating collar is W, the width of the conductive layer can extend from the outer edge inwards to 0.5W~0.7W. A ring-shaped insulating buffer zone is retained near the mouse's neck to avoid false alarm signals caused by accidental contact between the first conductive element 203 and the second conductive element 204 due to neck skin folds when the mouse is not rubbing its limbs or scratching its face (such as when turning its head or eating).

[0071] In some embodiments, the insulating collar is a frustum-shaped collar, similar to an Elizabethan collar worn by pets. When worn on the insulating collar, the larger end of the frustum-shaped collar extends away from the neck. This frustum-shaped collar can be formed by bending a flat ring, and a lightweight, insulating, and flexible sheet material can be used to ensure that the total weight of the finished product is controlled below 2 grams, avoiding the negative effects of excessive weight.

[0072] In some embodiments, the outer diameter of the frustum-shaped collar (the end furthest from the mouse's neck when worn) is 40 mm, and the inner diameter of the collar (the end closer to the mouse's neck when worn) is 20 mm, resulting in a 40% circular ring after cutting.

[0073] In some embodiments, to further improve accuracy, the inner ring of the insulating collar may be polished, and an anti-abrasion pad may be adhered to the inner ring as a lining. For ease of wear, the insulating collar may be cut open, and Velcro may be attached to the opening to ensure a secure and tight fit when worn, forming a conical ring.

[0074] In some embodiments, to improve accuracy when determining the behavioral indicators of mice, an insulating collar can be worn on the neck of the mouse in advance to allow it to adapt to the insulating collar. During adaptation, it can be worn continuously for up to 3 days, and for up to 2 hours each day, so that it gets used to the presence of the insulating collar and reduces the stress behavior caused by the novelty and discomfort of the insulating collar.

[0075] In some embodiments, the behavior analysis device further includes a voltage divider module 207 and a third conductive element 205; the third conductive element 205 is connected to the high potential end and the voltage divider module 207; and the first conductive element 203 is connected to the voltage divider module 207 and the conductive layer.

[0076] Specifically, the voltage divider module 207 can be a voltage divider resistor. The third conductive element 205 can be a wire, one end of which is connected to the high-potential end, and the other end is connected to one end of the voltage divider resistor. The other end of the voltage divider resistor is connected to the conductive layer through the first conductive element 203. That is, the high-potential end is connected to the voltage divider resistor through the third conductive element 205, and the voltage divider resistor is connected to the conductive layer through the first conductive element 203. The voltage divider module 207 can prevent the constant supply voltage from being too high and harming the mice. In other words, the voltage divider module 207 can also be understood as a current-limiting protection module, which limits the current flowing through the mice to the microampere (μA) level to protect the mice and prevent stress responses caused by current stimulation.

[0077] In some embodiments, the voltage divider resistor is in the kΩ range, which limits the current in the circuit to a level of microamps (μA) that is absolutely safe and will not be perceived by the mouse. For example, the voltage divider resistor can be 47 kΩ, 50 kΩ, 55 kΩ, 60 kΩ, etc.

[0078] In some embodiments, the constant voltage power supply module and the sampling module can be an integrated power analyzer 206, which can provide a constant supply voltage and also collect current in the circuit. Of course, the constant voltage power supply module and the sampling module can also be two separate devices, as those skilled in the art can determine based on the actual situation; no further limitations are made here. For example, the sampling module can be any device capable of detecting instantaneous current changes with high sensitivity (microamp level), such as a high-precision data acquisition card, an oscilloscope, or a custom amplifier circuit.

[0079] In some embodiments, this application provides a behavior monitoring device for determining behavioral indicators of an animal 100. For example... Figure 1As shown, the behavior monitoring device may include a constant voltage power supply module, a conductive platform 202, a first conductive element 203, a second conductive element 204, an insulating element 201, and a sampling module. The constant voltage power supply module includes a high-potential end and a low-potential end, which are used to form a constant supply voltage between the high-potential end and the low-potential end. The conductive platform 202 is used to support the animal 100 and ground it. The first conductive element 203 is connected to the high-potential end. The second conductive element 204 is connected to the low-potential end and the conductive platform 202. The insulating element 201 is worn on the body of the animal 100. A conductive layer is provided at a first position of the insulating element 201, and the conductive layer is connected to the first conductive element 203. The conductive layer can contact the animal 100 at the first position, and when the animal 100 contacts the conductive layer, a circuit is formed between the high-potential end and the low-potential end, generating an electrical signal. The electrical signal is used to characterize the behavior of the animal 100. The sampling module is used to collect the electrical signal for a first duration and generate monitoring results based on the collected electrical signal. The electrical signal includes the current signal and / or voltage signal of the circuit. The monitoring results are used to analyze the behavioral indicators of the animal 100. Specific embodiments of the behavior analysis device described above are not further limited here.

[0080] The above examples illustrate the present invention only to aid in understanding it and are not intended to limit the scope of the invention. Those skilled in the art can make various simple deductions, modifications, or substitutions based on the principles of this invention.

Claims

1. A behavior analysis device, characterized in that, The behavioral analysis device, used to determine behavioral indicators of animals, includes: A constant voltage power supply module includes a high potential terminal and a low potential terminal, and the constant voltage power supply module is used to form a constant supply voltage between the high potential terminal and the low potential terminal; A conductive platform for supporting the animal and for grounding; A first conductive element is connected to the high-potential terminal; The second conductive element connects the low-potential terminal and the conductive platform; An insulating component is provided for wearing on the body of the animal. A conductive layer is provided at a first position of the insulating component, and the conductive layer is connected to the first conductive component. The conductive layer can contact the animal at the first position, and when the animal contacts the conductive layer, a circuit is formed between the high potential end and the low potential end, and an electrical signal is generated. The electrical signal is used to characterize the behavior of the animal. A sampling module is used to acquire electrical signals for a first duration and generate monitoring results based on the acquired electrical signals; the electrical signals include current signals and / or voltage signals of the circuit; An analysis module is used to acquire the monitoring results and analyze the electrical signals in the monitoring results to determine the behavioral indicators.

2. The behavior analysis device as described in claim 1, characterized in that, The insulating component includes an insulating collar for wearing around the neck of the animal, with the first position located on the insulating collar.

3. The behavior analysis device as described in claim 2, characterized in that, The insulating collar is a frustum-shaped collar.

4. The behavior analysis device as described in claim 2, characterized in that, The insulating collar is made of resin or glass fiber reinforced epoxy resin composite substrate.

5. The behavior analysis device as described in any one of claims 2-4, characterized in that, The first position is located on the outer ring of the insulating collar.

6. The behavior analysis device as described in claim 1, characterized in that, The behavior analysis device further includes: a voltage divider module and a third conductive element; The third conductive component connects the high-potential terminal and the voltage divider module; The first conductive element connects the voltage divider module and the conductive layer.

7. The behavior analysis device as described in claim 1, characterized in that, The animal is a mouse; the mouse can come into contact with the conductive layer when it rubs its limbs or scratches its face.

8. The behavior analysis device as described in claim 1, characterized in that, The analysis of the data in the monitoring results to obtain the behavioral indicators includes: Remove signals from the monitoring results whose peak electrical signal value is less than a first preset threshold; The retained signals are grouped. Two adjacent electrical signals with a time interval less than or equal to a second preset threshold belong to the same signal group. For two adjacent electrical signals with a time interval greater than the second preset threshold, the first electrical signal is taken as the end point of the current signal group, and the second electrical signal is taken as the start point of the new signal group. Remove signal groups whose duration between the start and end points is less than a third preset threshold, and signal groups whose peak value is greater than a fourth preset threshold; Determine the total number of signal groups to be retained, the duration between the start point signal of the first signal group and the end point signal of the last signal group in the retained signal groups, and the integral area of ​​each signal group in the retained signal groups relative to the baseline; The animal's behavioral indicators are determined based at least on the total number, the total duration, and the area of ​​each integral, in order to analyze the animal's oral pain model.

9. The behavior analysis device as described in claim 8, characterized in that, The determination of the animal's behavioral indicators based at least on the total number, the total duration, and each integral area includes: Determine the number of signal groups in the retained signal groups per unit time; Determine the ratio of the total duration to the total number; The behavioral index is determined based on the total number, the total duration, the area of ​​each integral, the number of signal groups in the retained signal group per unit time, and the ratio.

10. A behavior monitoring device, characterized in that, The behavioral monitoring device, used to determine behavioral indicators of animals, includes: A constant voltage power supply module includes a high potential terminal and a low potential terminal, and the constant voltage power supply module is used to form a constant supply voltage between the high potential terminal and the low potential terminal; A conductive platform for supporting animals and for grounding; A first conductive element is connected to the high-potential terminal; The second conductive element connects the low-potential terminal and the conductive platform; An insulating component is used to be worn on the body of the animal. A conductive layer is provided at a first position of the insulating component, and the conductive layer is connected to the first conductive component. The conductive layer can contact the animal at the first position, and when the animal contacts the conductive layer, a circuit is formed between the high potential end and the low potential end, and an electrical signal is generated. A sampling module is used to acquire electrical signals for a first duration and generate monitoring results based on the acquired electrical signals; the electrical signals include current signals and / or voltage signals of the circuit; the monitoring results are used to analyze the behavioral indicators.

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