Full-automatic sample treatment instrument

Abstract

The invention relates to a full-automatic sample treatment instrument, and relates to the technical field of sample treatment instruments, the full-automatic sample treatment instrument comprises an instrument body, a mechanical arm mechanism, a centrifugal mechanism and a plurality of placing mechanisms for placing test tubes; the device further comprises a nitrogen blowing box, a communicating pipe, a plurality of nitrogen blowing pipes, a movable frame and a poke rod, wherein the plurality of nitrogen blowing pipes are in one-to-one correspondence with the test tubes; a sensor for detecting the nitrogen blowing amount in the test tube is arranged on the outer wall of the nitrogen blowing tube, and after the sensor detects that the nitrogen blowing amount in the test tube reaches a set standard, the nitrogen blowing tube moves upwards to be away from the test tube through the lifting assembly. The sensors are arranged on the outer walls of all the nitrogen blowing pipes, the nitrogen blowing amount in the test tubes is monitored in real time, when the sensors detect that the nitrogen blowing amount reaches the set standard, the nitrogen blowing pipes are automatically lifted through the lifting assemblies, nitrogen blowing on the test tubes is stopped, accurate control over the nitrogen blowing amount of each test tube is achieved, and the nitrogen blowing efficiency is improved. Sample loss caused by excessive purging or incomplete treatment caused by insufficient purging is avoided, and the effect of improving the accuracy and reliability of sample treatment is achieved.

Description

Technical Field

[0001] This application relates to the field of sample processing technology, and more specifically, to a fully automated sample processing instrument. Background Technology

[0002] Currently, in fields such as chemical analysis, biopharmaceuticals, and environmental monitoring, sample pretreatment is a crucial step in ensuring the accuracy and reliability of analytical results. Nitrogen blowing concentration, as an efficient and rapid sample processing method, is widely used for solvent removal and target compound concentration. Traditional fully automated sample processing instruments rely heavily on manual operation, resulting in low efficiency, uneven nitrogen usage, and a high risk of cross-contamination between samples.

[0003] With the development of automation technology, some semi-automatic or fully automatic sample processing instruments have appeared on the market. In the nitrogen blowing process, how to accurately control the amount of nitrogen blown into each test tube and avoid over-blowing or under-blowing has become the key to improving nitrogen blowing efficiency and sample processing quality.

[0004] To address the aforementioned technologies, developing a sample processing instrument that is simple in structure, easy to operate, highly automated, and capable of precisely controlling nitrogen blowing volume is of great significance for improving sample processing efficiency and quality. Summary of the Invention

[0005] The purpose of this application is to provide a fully automated sample processing instrument that solves the technical problem of difficulty in controlling the nitrogen blowing volume of each test tube in related / existing technologies.

[0006] In the first aspect, the fully automatic sample processing instrument provided in this application adopts the following technical solution: it includes an instrument body and a robotic arm mechanism that slides within the instrument body. The instrument body is provided with a centrifugation mechanism and multiple placement mechanisms for placing test tubes. The placement mechanism containing test tubes is placed onto the centrifugation mechanism by the robotic arm mechanism for centrifugation. A nitrogen blowing box, wherein multiple connecting tubes are fixedly connected inside the nitrogen blowing box, and nitrogen blowing tubes are movably sleeved inside the connecting tubes, and the multiple nitrogen blowing tubes correspond one-to-one with the test tubes on the placement mechanism that enters the nitrogen blowing box; A sensor for detecting the amount of nitrogen blown into the test tube is provided on the outer wall of the nitrogen blowing tube. A lifting component is provided between the connecting tube and the nitrogen blowing tube. When the sensor detects that the amount of nitrogen blown into the test tube has reached the set standard, the lifting component moves the nitrogen blowing tube upward away from the test tube. A horizontally movable frame, wherein the movable frame is provided with a lever that rotates in conjunction with the nitrogen blowing pipe; The test tubes are placed into the centrifugation mechanism for pretreatment by a robotic arm, and then transferred to the nitrogen blowing box. The nitrogen blowing tubes correspond one-to-one with the test tubes. The sensors monitor the nitrogen blowing volume in real time. After the standard is met, the lifting component automatically lifts the nitrogen blowing tubes. The movable frame drives the lever to reciprocate, causing the nitrogen blowing tubes to rotate and evenly blow the test tubes.

[0007] Preferably, the bottom of the nitrogen blowing tube is L-shaped, and a protective tube is fixedly connected to the connecting tube. The protective tube moves through the nitrogen blowing tube. The instrument body is also provided with a mixing mechanism and an oscillation mechanism. The protective tube protects the sensor connection wire to prevent it from getting tangled during rotation, and the mixing mechanism and the oscillation mechanism mix the sample thoroughly by rotation or vibration.

[0008] Preferably, the inner wall of the connecting pipe is fixedly connected to two limiting rings, and the outer wall of the nitrogen blowing pipe is fixedly connected to a sliding ring that moves between the two limiting rings; the sliding ring slides between the limiting rings to ensure that the nitrogen blowing pipe does not deviate when it moves vertically, and the gap between the limiting ring and the sliding ring is sealed to prevent nitrogen leakage.

[0009] Preferably, the lifting assembly includes an electric telescopic rod fixedly connected to the connecting pipe, a movable ring fixedly connected to the telescopic end of the electric telescopic rod, and a connecting plate rotatably connected to the outer surface of the nitrogen blowing pipe; the electric telescopic rod pushes the movable ring, driving the connecting plate and the nitrogen blowing pipe to rise and fall, and the connecting plate is rotatably connected to the movable ring, allowing the nitrogen blowing pipe to rotate.

[0010] Preferably, the bottom of the connecting plate is fixedly connected to a plurality of L-shaped plates arranged in a circular matrix, and the L-shaped plates are in abutting engagement with the actuating rod; when the movable frame reciprocates, the actuating rod periodically presses against the L-shaped plates, driving the nitrogen blowing pipe to reciprocate.

[0011] Preferably, the movable frame is provided with a sliding groove, and a slider is slidably engaged in the sliding groove by a spring. The actuating rod is rotatably connected to the slider. The spring buffers the impact force between the actuating rod and the L-shaped plate, and the slider adapts to the small displacement of the nitrogen blowing pipe.

[0012] Preferably, the connecting plate is located below the movable frame, and a horizontal plate that slides horizontally within the nitrogen blowing box is fixedly connected to the end of the movable frame; the horizontal plate restricts the movement trajectory of the movable frame and prevents lateral deviation.

[0013] Preferably, a motor is fixedly connected inside the nitrogen blowing box, and an L-shaped rotating rod is fixedly connected to the output shaft of the motor. A sliding groove is provided on the movable frame, and the bottom end of the L-shaped rotating rod slides in the sliding groove. The motor drives the L-shaped rotating rod to rotate, which is converted into linear motion of the movable frame through the sliding groove, thereby causing the movable frame to reciprocate.

[0014] In summary, this application includes at least one of the following beneficial technical effects: 1. In this invention, a robotic arm mechanism automatically moves a placement mechanism containing test tubes into a nitrogen blowing box, and multiple nitrogen blowing tubes are used to simultaneously blow nitrogen into multiple test tubes. The bottom of the nitrogen blowing tube is designed in an L-shape and is used in conjunction with a lever to achieve reciprocating rotation, so that nitrogen is blown into the test tubes evenly, thereby enhancing the nitrogen blowing effect.

[0015] 2. A sensor is installed on the outer wall of each nitrogen blowing tube to monitor the amount of nitrogen blowing in the tube in real time. When the sensor detects that the amount of nitrogen blowing has reached the set standard, the nitrogen blowing tube is automatically raised by the lifting component to stop blowing nitrogen into the tube. This achieves precise control of the amount of nitrogen blowing in each tube, avoids sample loss due to over-blowing or incomplete processing due to insufficient blowing, and improves the accuracy and reliability of sample processing.

[0016] 3. Each nitrogen blowing tube corresponds to a test tube, and the nitrogen blowing tube does not directly contact the inner wall of the test tube during the nitrogen blowing process, reducing the risk of cross-contamination. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the overall structure in one embodiment of the present invention; Figure 2 for Figure 1 A front view of the overall structure in the embodiment; Figure 3 This is a schematic diagram of the internal structure of the instrument body of the present invention; Figure 4 This is a schematic diagram of the nitrogen blowing box structure of the present invention; Figure 5 This is a schematic cross-sectional view of the nitrogen blowing box structure of the present invention; Figure 6 This is a schematic diagram of the combined structure of the connecting pipe and the nitrogen blowing pipe of the present invention; Figure 7 For the present invention Figure 6 Diagram of the structural breakdown; Figure 8 This is a schematic diagram of the structure of the movable frame and the nitrogen blowing pipe of the present invention. Figure 9 This is a schematic diagram showing the disassembled structure of the nitrogen blowing pipe and sensor of the present invention; Figure 10 This is a schematic diagram of the connection structure between the nitrogen blowing pipe and the connecting pipe of the present invention; Figure 11 This is a schematic diagram showing the disassembled structure of the nitrogen blowing pipe and the connecting pipe of the present invention; Figure 12 This is a schematic diagram of the mating structure of the L-shaped plate and the actuating rod of the present invention.

[0018] Explanation of reference numerals in the attached drawings: 1. Instrument body; 2. Robotic arm mechanism; 3. Centrifugation mechanism; 4. Placement mechanism; 5. Nitrogen blowing box; 6. Connecting pipe; 7. Nitrogen blowing tube; 8. Sensor; 9. Movable frame; 10. Actuating rod; 11. Protective tube; 12. Mixing mechanism; 13. Oscillation mechanism; 14. Limiting ring; 15. Sliding ring; 16. Electric telescopic rod; 17. Movable ring; 18. Connecting plate; 19. L-shaped plate; 20. Sliding groove; 21. Spring; 22. Slider; 23. Horizontal plate; 24. Motor; 25. L-shaped rotating rod; 26. Sliding groove. Detailed Implementation

[0019] The following combination Figures 1-12 This application will be described in further detail below.

[0020] This invention provides a fully automatic sample processing instrument, including an instrument body 1 and a robotic arm mechanism 2 that slides within the instrument body 1. The robotic arm mechanism 2 has a motor inside the instrument body 1, which is connected to a threaded rod, so that the robotic arm mechanism 2 always slides horizontally against the inner wall of the instrument body 1. That is, the robotic arm mechanism 2 includes a box and multiple intelligent robotic arms located inside the box. The threaded rod is threadedly connected to the box, and the top surface of the box always slides against the inner wall of the instrument body 1 (the box cannot change angle; under the action of the threaded rod, the box only moves in the horizontal direction). The instrument body 1 is equipped with a centrifugation mechanism 3 and multiple placement mechanisms 4 for placing test tubes. The placement mechanism 4 containing test tubes is placed on the centrifugation mechanism 3 by the robotic arm mechanism 2 for centrifugation. The instrument body 1 is also equipped with a mixing mechanism 12 and an oscillation mechanism 13. By placing the placement mechanism 4 containing test tubes into the mixing mechanism 12 or the oscillation mechanism 13, the mixing mechanism 12 or the oscillation mechanism 13 uses mechanical movement (such as rotation or vibration) to fully mix the samples in the test tubes, eliminating concentration gradients or precipitation. A nitrogen blowing box 5 has multiple connecting pipes 6 fixedly connected inside it. The connecting pipes 6 are fixed inside the nitrogen blowing box 5 and do not move relative to the nitrogen blowing box 5. A nitrogen blowing tube 7 is movably sleeved inside the connecting pipe 6, and nitrogen gas is delivered to the nitrogen blowing tube 7 through the connecting pipe 6. Each of the multiple nitrogen blowing tubes 7 corresponds to a test tube on the placement mechanism 4 that enters the nitrogen blowing box 5. Nitrogen gas is blown into the test tube through the nitrogen blowing tube 7. Two limiting rings 14 are fixedly connected to the inner wall of the connecting pipe 6, and a sliding ring 15 is fixedly connected to the outer wall of the nitrogen blowing tube 7 and moves between the two limiting rings 14. Under the premise of ensuring the sealing between the connecting pipe 6 and the nitrogen blowing tube 7, the movement of the nitrogen blowing tube 7 up and down along the connecting pipe 6 is not affected, and the rotation of the nitrogen blowing tube 7 relative to the connecting pipe 6 is not affected.

[0021] A sensor 8 for detecting the amount of nitrogen blown into the tube is fixedly connected to the outer wall of the nitrogen blowing tube 7. A lifting assembly is provided between the connecting tube 6 and the nitrogen blowing tube 7. The lifting assembly includes an electric telescopic rod 16 that is fixedly connected to the connecting tube 6. A movable ring 17 is fixedly connected to the telescopic end of the electric telescopic rod 16. A connecting plate 18 that is rotatably connected to the movable ring 17 is fixedly connected to the outer surface of the nitrogen blowing tube 7. When sensor 8 detects that the nitrogen blowing volume in the test tube has reached the set standard, the nitrogen blowing tube 7 is moved upward and away from the test tube by the lifting component; Furthermore, the movable frame 9 is horizontally movable, and the movable frame 9 is equipped with a lever 10 that rotates with the nitrogen blowing pipe 7. A motor 24 is fixedly connected inside the nitrogen blowing box 5, and the output shaft of the motor 24 is fixedly connected to an L-shaped rotating rod 25. The movable frame 9 has a sliding groove 26, and the bottom end of the L-shaped rotating rod 25 slides in the sliding groove 26. The connecting plate 18 is located below the movable frame 9, and a horizontal plate 23 that slides horizontally inside the nitrogen blowing box 5 is fixedly connected to the end of the movable frame 9. Multiple L-shaped plates 19 arranged in a circular matrix are fixedly connected to the bottom of the connecting plate 18, and the L-shaped plates 19 are in abutment with the lever 10. When the nitrogen blowing pipe 7 is inserted into the test tube and blows air into the test tube, the nitrogen blowing pipe 7 slowly rotates, so that the nitrogen is blown into the test tube evenly, which facilitates uniform evaporation in the test tube and enhances the nitrogen blowing efficiency. The bottom of the nitrogen blowing pipe 7 is L-shaped. A protective pipe 11 is fixedly connected to the connecting pipe 6. The protective pipe 11 moves through the nitrogen blowing pipe 7. The sensor 8 is located in the middle. The connecting wire of the sensor 8 is a flexible wire. The flexible wire is fixedly installed inside the protective pipe 11. The setting of the flexible wire does not affect the up and down movement and rotation of the sensor 8. When rotating, the flexible wire is wound up to a certain extent. The nitrogen blowing pipe 7 rotates back and forth at a certain angle and does not rotate in a clockwise direction.

[0022] The movable frame 9 is provided with a sliding groove 20. A slider 22 is slidably engaged in the sliding groove 20 through a spring 21. The actuating rod 10 is rotatably connected to the slider 22. The setting of the spring 21 ensures that the descending L-shaped plate 19 can smoothly press against the actuating rod 10, thereby ensuring that the nitrogen blowing tube 7 reciprocates after descending and uniformly blows nitrogen into the test tube.

[0023] Working principle: When the test tube is placed into the nitrogen blowing box 5, the position of the test tube opening corresponds to the position of the nitrogen blowing tube 7; First, the electric telescopic rod 16 is activated. The telescopic end of the electric telescopic rod 16 drives the movable ring 17 and the connecting plate 18 to move downward. The movable ring 17 will not detach from the connecting plate 18 and will not affect the mutual rotation between the movable ring 17 and the connecting plate 18. The connecting plate 18 moves downward, driving the nitrogen blowing tube 7 to move downward synchronously, thereby allowing the nitrogen blowing tube 7 to penetrate into the test tube. At the same time, the sliding ring 15 is driven to slide between the two limiting rings 14, which on the one hand ensures that the nitrogen blowing pipe 7 moves downward relative to the connecting pipe 6, and on the other hand ensures the airtightness between the nitrogen blowing pipe 7 and the connecting pipe 6, avoiding air leakage between the nitrogen blowing pipe 7 and the connecting pipe 6. It is worth noting that: the nitrogen blowing pipe 7 moves downward synchronously, the connecting plate 18 and the L-shaped plate 19 descend synchronously, and the vertical height of the L-shaped plate 19 after descending moves with the vertical height of the lever 10. Due to the action of the spring 21, the horizontal position of the lever 10 can be finely adjusted to prevent the descending L-shaped plate 19 from contacting the lever 10, which would prevent the L-shaped plate 19 from descending to a position that is synchronized with the vertical height of the lever 10. Then, nitrogen gas is blown into the test tube through the nitrogen blowing box 5, the connecting pipe 6 and the nitrogen blowing pipe 7, and the inside of the test tube is evaporated. Finally, start the motor 24 to rotate the L-shaped rotating rod 25. Under the restriction of the horizontal plate 23, the L-shaped rotating rod 25 slides back and forth in the slide groove 26, thereby causing the movable frame 9 to move back and forth along the direction of the horizontal plate 23. The reciprocating movable frame 9 drives the slider 22 and the actuating rod 10 to reciprocate. The reciprocating actuating rod 10 presses against the L-shaped plate 19, causing the nitrogen blowing tube 7 to reciprocate at a certain angle (not exceeding 360°), which helps to improve the nitrogen blowing efficiency. The radius of the circumferential motion of the L-shaped nitrogen blowing tube 7 is smaller than the inner diameter of the test tube. When sensor 8 detects that evaporation has been completed in the test tube, sensor 8 sends a signal to stop the delivery of nitrogen gas in the corresponding connecting tube 6 to save nitrogen gas. At the same time, the electric telescopic rod 16 extends and retracts, thereby causing the nitrogen blowing tube 7 to detach from the test tube. In this application, sensor 8 is a humidity sensor 8, which determines the drying status by detecting the humidity in the test tube.

[0024] The embodiments described in this specific implementation are preferred embodiments of this application and are not intended to limit the scope of protection of this application. Identical components are represented by the same reference numerals. Therefore, all equivalent changes made to the structure, shape, and principle of this application should be covered within the scope of protection of this application.

Claims

1. A fully automated sample processing instrument, comprising: The instrument body (1) also includes a robotic arm mechanism (2) that slides within the instrument body (1). The instrument body (1) is characterized by having a centrifugation mechanism (3) and multiple placement mechanisms (4) for placing test tubes. The placement mechanism (4) containing test tubes is placed onto the centrifugation mechanism (3) by the robotic arm mechanism (2) for centrifugation. Nitrogen blowing box (5), a plurality of connecting tubes (6) are fixedly connected inside the nitrogen blowing box (5), and nitrogen blowing tubes (7) are movably sleeved inside the connecting tubes (6). The plurality of nitrogen blowing tubes (7) correspond one-to-one with the test tubes on the placement mechanism (4) that enters the nitrogen blowing box (5). The nitrogen blowing tube (7) is provided with a sensor (8) on the outer wall to detect the amount of nitrogen blowing in the test tube. A lifting component is provided between the connecting tube (6) and the nitrogen blowing tube (7). When the sensor (8) detects that the amount of nitrogen blowing in the test tube has reached the set standard, the nitrogen blowing tube (7) is moved up away from the test tube by the lifting component. A horizontally movable frame (9) is provided with a lever (10) that rotates with the nitrogen blowing pipe (7).

2. The fully automated sample processing instrument according to claim 1, characterized in that: The bottom of the nitrogen blowing tube (7) is L-shaped, and a protective tube (11) is fixedly connected to the connecting tube (6). The protective tube (11) moves through the nitrogen blowing tube (7). The instrument body (1) is also equipped with a mixing mechanism (12) and an oscillation mechanism (13).

3. The fully automated sample processing instrument according to claim 1, characterized in that: The inner wall of the connecting pipe (6) is fixedly connected to two limiting rings (14), and the outer wall of the nitrogen blowing pipe (7) is fixedly connected to a sliding ring (15) that moves between the two limiting rings (14).

4. The fully automated sample processing instrument according to claim 1, characterized in that: The lifting assembly includes an electric telescopic rod (16) that is fixedly connected to the connecting pipe (6). The telescopic end of the electric telescopic rod (16) is fixedly connected to a movable ring (17). The outer surface of the nitrogen blowing pipe (7) is fixedly connected to a connecting plate (18) that is rotatably connected to the movable ring (17).

5. The fully automated sample processing instrument according to claim 4, characterized in that: The bottom of the connecting plate (18) is fixedly connected to a plurality of L-shaped plates (19) arranged in a circular matrix, and the L-shaped plates (19) are in abutting fit with the actuating rod (10).

6. The fully automated sample processing instrument according to claim 1, characterized in that: The movable frame (9) is provided with a sliding groove (20), and a slider (22) is slidably engaged in the sliding groove (20) by a spring (21). The actuating rod (10) is rotatably connected to the slider (22).

7. The fully automated sample processing instrument according to claim 1, characterized in that: The connecting plate (18) is located below the movable frame (9), and the end of the movable frame (9) is fixedly connected to a horizontal plate (23) that slides horizontally inside the nitrogen blowing box (5).

8. The fully automated sample processing instrument according to claim 1, characterized in that: A motor (24) is fixedly connected inside the nitrogen blowing box (5). An L-shaped rotating rod (25) is fixedly connected to the output shaft of the motor (24). A sliding groove (26) is provided on the movable frame (9). The bottom end of the L-shaped rotating rod (25) slides in the sliding groove (26).

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