Blood pretreatment assembly and LCMS all-in-one machine

Abstract

The invention discloses a blood pretreatment assembly and an LCMS all-in-one machine, and relates to the technical field of sample testing, the blood pretreatment assembly comprises a carrying mechanism, a blood collection tube feeding position, a reagent bottle storage position, a centrifugal tube feeding position, a centrifugal position and a cooling module, and the cooling module comprises a refrigeration assembly and a heat dissipation assembly; in the first direction, the refrigeration assembly is located below the blood collection tube feeding position and / or the reagent bottle storage position; the heat dissipation assembly is located at the heat dissipation end of the refrigeration assembly and comprises a sealing cavity, a first air inlet is formed in the first side of the sealing cavity, a second air inlet is formed in the second side of the sealing cavity, an air outlet is formed in the third side of the sealing cavity, and the direction of the first air inlet intersects with the direction of the second air inlet. And air from the first air inlet to the corresponding corner of the air outlet is circulated and replaced. Therefore, the mechanism can achieve heat exchange without space replacement and dead angles, the heat dissipation efficiency of the heat dissipation assembly is improved, and therefore the refrigeration effect and efficiency of the refrigeration assembly are improved.

Description

Technical Field

[0001] This application relates to the field of sample testing technology, and more specifically, to a blood pretreatment component and an integrated LCMS system. Background Technology

[0002] Liquid chromatography-mass spectrometry (LCMS) systems, as core tools of modern analytical science, are widely used in drug development, clinical diagnosis, environmental monitoring, food safety, and life science research due to their high sensitivity, high selectivity, and powerful qualitative and quantitative capabilities.

[0003] To meet the temperature requirements of the LCMS all-in-one machine, the sample loading mechanism needs to be equipped with a cooling component. The cooling performance of the cooling component is greatly affected by the environment at the heat dissipation end. The higher the ambient temperature at the heat dissipation end, the more difficult the heat dissipation becomes, and the worse the cooling effect and efficiency of the cooling component will be. In particular, when the heat dissipation environment is in a corner, heat dissipation becomes even more difficult.

[0004] Therefore, it is necessary to provide a blood pretreatment component and an integrated LCMS machine that can improve the cooling effect and efficiency of the cooling component by increasing the heat dissipation efficiency of the cooling component's heat dissipation end. Summary of the Invention

[0005] In view of this, the purpose of this application is to provide a blood pretreatment component and an integrated LCMS machine, so as to improve the cooling effect and efficiency of the cooling component by improving the heat dissipation efficiency of the heat dissipation end of the cooling component.

[0006] To achieve the above objectives, this application provides the following technical solution:

[0007] In a first aspect, this application provides a blood pretreatment assembly, including a transport mechanism, a blood collection tube loading station, a reagent bottle storage station, a centrifuge tube loading station, a centrifugation station, and a cooling module, wherein:

[0008] The blood collection tube loading position is used to store blood collection tubes, which are used to hold blood.

[0009] The reagent bottle storage compartment is used to store reagent bottles, which are used to hold reagents.

[0010] The centrifuge tube loading level is used to store centrifuge tubes, which are used to hold mixtures of reagents and blood.

[0011] The transport mechanism is used for transporting and / or pipetting liquids between the blood collection tube loading point, the centrifuge tube loading point, and the centrifugation point;

[0012] The cooling module includes a refrigeration component and a heat dissipation component. In a first direction, the refrigeration component is located below the blood collection tube loading position and / or the reagent bottle storage position. The heat dissipation component is located at the heat dissipation end of the refrigeration component and includes a sealed cavity. A first air inlet is provided on the first side of the sealed cavity, a second air inlet is provided on the second side of the sealed cavity, and an air outlet is provided on the third side of the sealed cavity. The direction of the first air inlet intersects with that of the second air inlet, so as to allow air to circulate and replace the air at the corresponding corner from the first air inlet to the air outlet.

[0013] In some embodiments, the cooling assembly includes a cooling plate and a cooling block. The lower surface of the cooling plate serves as the heat dissipation end of the cooling assembly and is in contact with the heat dissipation assembly. The upper surface of the cooling plate is in direct or indirect contact with the cooling block. The cooling block is in direct or indirect contact with the blood collection tube loading position and the reagent bottle storage position.

[0014] In some embodiments, the blood pretreatment assembly further includes a switch cap position for opening and closing the caps on blood collection tubes and / or centrifuge tubes.

[0015] In some embodiments, the switch cover position includes a first switch cover module and a second switch cover module. The first switch cover module is used to perform an opening action on the blood collection tubes transported by the transport mechanism from the blood collection tube loading position; the second switch cover module is used to perform an opening and closing action on the centrifuge tubes transported by the transport mechanism from the centrifuge tube loading position.

[0016] In some embodiments, the switch cap position also includes a reagent adding module, which is used to add reagents to the centrifuge tube located at the second switch cap module after the cap has been opened.

[0017] In some embodiments, the switch cover position further includes a third switch cover module, which is used to open the cover of the mixed centrifuge tube that has been transported from the centrifuge tube loading position by the conveying mechanism.

[0018] In some embodiments, the blood pretreatment assembly further includes an injection station for delivering the target fluid to a designated location.

[0019] In some embodiments, the injection station includes a sampling module and an injection module, wherein the sampling module is capable of drawing up the target liquid and dispensing the target liquid into the injection module, and the injection module is capable of delivering the target liquid to a designated location.

[0020] In some embodiments, the injection station further includes a fourth switch cap module and a dilution module. The fourth switch cap module is used to open the injection tube, and the dilution module is used to inject diluent into the opened injection tube to form the target liquid.

[0021] In some embodiments, the injection station also includes a transfer module, which is located on the first side of the fourth switch cap module and can drive the injection tube to switch between the initial station, the cap opening station, the dilution station and the sampling station.

[0022] The fourth switch cover module is located above the cover opening station and can open the sample tube located at the cover opening station.

[0023] The dilution module is located above the dilution station and can add diluent to the injection tube located at the dilution station, which is situated between the initial station and the capping station.

[0024] The sampling module is located on the second side of the fourth switch cover module and above the sampling station. The sampling module can perform an aspiration action on the sample inlet tube located at the sampling station to aspirate the target liquid; and the sampling module can move above the sample inlet module and eject the target liquid into the sample inlet module.

[0025] The injection module can deliver the target liquid to a designated location.

[0026] In some embodiments, the fourth cap opening module includes a first moving component, a second moving component, a cap opening gripper, a bottle body gripper, and a tube seat. The first moving component extends along a third direction, and the moving end of the first moving component is connected to the tube seat so that the tube seat moves along a third direction between the initial station and the cap opening station. The tube seat is used to install sample bottles.

[0027] The second moving component extends along the first direction, and the moving end of the second moving component is connected to the opening gripper to drive the opening gripper to move in the first direction.

[0028] In some embodiments, the transplanting module includes a first guide rail module, a second guide rail module, and a pipe clamp.

[0029] The first guide rail module extends along the second direction;

[0030] The second guide rail module extends along the third direction. The fixed end of the second guide rail module is set at the sliding end of the first guide rail module. The sliding end of the second guide rail module is connected to the tube clamp to drive the tube clamp to move between the dilution station and the sampling station along the third direction. The tube clamp is used to install the injection tube clamp. The first direction and the second direction are perpendicular to the third direction.

[0031] In some embodiments, the second guide rail module includes a first bracket, a first motor, a first transmission assembly, a first guide assembly, and a push rod. The first bracket extends along a third direction and is arranged at the sliding end of the first guide rail module. The first motor is mounted on the first bracket and is connected to the first transmission assembly. The push rod is connected to the first transmission assembly. A pipe clamp is mounted on the push rod. The first guide assembly connects the first bracket and the first transmission assembly to allow the push rod to move in a third direction.

[0032] In some embodiments, the dilution station is located on the first moving component, and the dilution module includes an injection head through which diluent is injected into the injection tube located at the dilution station.

[0033] In some embodiments, the sampling module includes a third moving component, a sampling needle, and a sampling tube. The third moving component extends along a first direction, and the moving end of the third moving component is connected to the sampling needle to drive the sampling needle to move in the first direction. The sampling tube is connected to the sampling needle to perform sampling and dispensing actions. The sampling station is located below the sampling needle.

[0034] In some embodiments, the injection module further includes a fourth moving component that extends along a third direction. The moving end of the fourth moving component is connected to the third moving component to drive the third moving component to move along the third direction. The injection needle seat is disposed at the fixed end of the fourth moving component to form an injection station.

[0035] In some embodiments, the conveying mechanism includes a motion spindle, a first conveying mechanism, and a second conveying mechanism. Both the first and second conveying mechanisms are mounted on the motion spindle to drive the first and second conveying mechanisms to move in a second direction and a third direction. The first and second conveying mechanisms are capable of moving in the first direction.

[0036] In some embodiments, the second transport mechanism includes a base, a drive assembly, at least two stages of motion assemblies, transport grippers, and a pipette. The at least two stages of motion assemblies are movably disposed on the base along a first direction. The first-stage motion assembly is drivenly connected to the drive assembly to generate a first-stage displacement. Adjacent motion assemblies are coupled together via belts to generate a last-stage displacement. The last-stage motion assembly is connected to the transport grippers and / or the pipette. The transport grippers are used to hold centrifuge tubes or sample tubes, and the pipette is used to mount pipette tips.

[0037] In some embodiments, the motion component includes two levels of motion components, namely a first motion component and a second motion component; the first motion component is located at the first level, and the second motion component is located at the last level;

[0038] The first motion component includes a first slide rail module, a first pulley, a first belt, and a first slider. The slider of the first slide rail module is mounted on a base, and the slide rail of the first slide rail module is movable relative to the slider. The first pulley is mounted on the base and is connected to the drive component for transmission. The first belt is wound around the first pulley. The first slider is mounted on the slide rail of the first slide rail module and fixed to the first belt to drive the slide rail of the first slide rail module to move a first distance.

[0039] The second motion component includes a second slide rail module, a second pulley, a second belt, a fixing block, a second slider, and a third slider. The slider of the second slide rail module is fixed on the slide rail of the first slide rail module, and the slide rail of the second slide rail module can move relative to the slider of the second slide rail module. The second pulley is set on the slide rail of the first slide rail module through the second slider. The second belt is wound around the second pulley. The fixing block fixes the second belt to the base. The third slider is fixed on the slide rail of the second slide rail module and fixed on the second belt to drive the slide rail of the second slide rail module to move a second distance.

[0040] In some embodiments, the centrifugation unit includes a centrifuge and a storage box. The centrifuge is used to perform a mixing action on the centrifuge tubes with the caps closed, which are transported from the second cap switching module by the second transport mechanism. The storage box is used to store pipette tips that are compatible with the first and second transport mechanisms.

[0041] Secondly, this application provides an integrated LCMS system, including the blood pretreatment component and the chromatography-mass spectrometry analysis component as described above.

[0042] In the blood pretreatment assembly of this application, a cooling module is provided below the blood collection tube loading position and / or reagent bottle storage position. The cooling module includes a refrigeration component and a heat dissipation component. The heat dissipation component is arranged at the heat dissipation end of the refrigeration component. Since the direction of the first air inlet of the heat dissipation component intersects with the second air inlet, the airflow direction from the first air inlet to the corner of the air outlet can be changed to achieve airflow displacement. Therefore, the above mechanism can achieve heat exchange without dead zones, improving the heat dissipation efficiency of the heat dissipation component, thereby improving the cooling effect and efficiency of the refrigeration component.

[0043] The technical features mentioned above, those to be mentioned below, and those shown individually in the accompanying drawings can be combined arbitrarily, provided that the combined technical features are not contradictory. All feasible combinations of features are the technical content explicitly described herein. Any one of the multiple sub-features contained in the same statement can be applied independently, without necessarily being applied together with other sub-features. Attached Figure Description

[0044] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of this application. For those skilled in the art, other drawings can be obtained based on the provided drawings without creative effort.

[0045] Figure 1 A top view of a blood pretreatment assembly provided in an embodiment of this application;

[0046] Figure 2 A top perspective view of the cooling module arranged at the material position on the blood collection tube and the reagent bottle storage position, provided in an embodiment of this application;

[0047] Figure 3 A bottom perspective view of the cooling module arranged at the material position on the blood collection tube and the reagent bottle storage position, as provided in an embodiment of this application;

[0048] Figure 4 A top view of the cooling module arranged at the material feeding position on the blood collection tube and the reagent bottle storage position, as provided in the embodiments of this application;

[0049] Figure 5 A cross-sectional view of the cooling module arranged at the blood collection tube feeding position and the reagent bottle storage position according to an embodiment of this application;

[0050] Figure 6 A perspective view of the second conveying mechanism provided in the embodiments of this application;

[0051] Figure 7 A perspective view of the second handling mechanism provided in the embodiments of this application, omitting the pipette and handling gripper;

[0052] Figure 8 A three-dimensional schematic diagram of the injection site provided in the embodiments of this application;

[0053] Figure 9 A perspective view of the transplanting module and the fourth switch cover module provided in the embodiment of the application;

[0054] Figure 10 A three-dimensional schematic diagram of the sampling module and the injection module provided in the embodiments of the application;

[0055] Among them, 100-blood collection tubes; 200-reagent bottles; 300-centrifuge tubes; 400-sample inlet tubes;

[0056] 1-Transportation mechanism; 2-Blood collection tube loading position; 3-Reagent bottle storage position; 4-Center tube loading position; 5-Centering position; 6-Post-centrifugation temporary storage position; 7-Sample tube loading position; 8-Cap opening / closing position; 9-Sample injection position;

[0057] 10-Refrigeration module; 11-Refrigeration component; 12-Heat dissipation component; 13-Condensate drainage component;

[0058] 111-Refrigeration plate; 112-Cooling block; 113-Temperature sensor; 1121-First cooling block; 11211-Guide groove; 1122-Second cooling block; 1123-Third cooling block; 11231-Containing cavity; 11232-Cooling channel;

[0059] 120 - Sealed cavity; 121 - First air inlet; 122 - Second air inlet; 123 - Air outlet; 124 - First housing; 125 - Second housing; 126 - First fan; 127 - Second fan; 128 - Heat dissipation fins;

[0060] 131-Drain tray; 132-Manifold; 133-Drain outlet;

[0061] 101-Base; 102-Drive assembly; 103-First motion assembly; 104-Second motion assembly; 105-Transfer gripper; 106-Pipette;

[0062] 1031-First slide rail module; 1032-First pulley; 1033-First belt; 1034-First slider; 1035-Idler pulley; 10311-Slide rail; 10312-Slider;

[0063] 1041 - Second slide rail module; 1042 - Second pulley; 1043 - Second belt; 1044 - Fixing block; 1045 - Second slider; 1046 - Third slider; 10411 - Slide rail; 10412 - Slider;

[0064] 51-Centrifuge; 52-Storage box;

[0065] 81-First switch cover module; 82-Second switch cover module; 83-Third switch cover module; 84-Reagent addition module;

[0066] 91-Transplanting module; 92-Fourth opening module; 93-Sampling module; 94-Sample injection module; 95-Dilution module;

[0067] 911 - First guide rail module; 912 - Second guide rail module; 913 - Pipe clamp;

[0068] 9121-First bracket; 9122-First motor; 9123-First transmission assembly; 91231-Third belt; 91232-Third pulley; 9124-First guide assembly; 91241-Fourth slider; 91242-Fourth slide rail; 9125-Push rod;

[0069] 921-First moving component; 922-Second moving component; 923-Opening gripper; 924-Bottle gripper; 925-Tube holder;

[0070] 9211-Second bracket; 9212-Second motor; 9213-Second transmission assembly; 92131-Fourth belt; 92132-Fourth pulley; 9214-Second guide assembly; 92141-Fifth slider; 92142-Fifth slide rail;

[0071] 9221 - Third support; 9222 - Third motor; 9223 - Third transmission assembly; 92231 - First lead screw; 92232 - First nut; 9224 - Third guide assembly; 92241 - Sixth slider; 92242 - Sixth slide rail;

[0072] 931 - Third moving component; 932 - Sampling needle; 933 - Sampling tubing;

[0073] 9311-Fourth bracket; 9312-Fourth motor; 9313-Fourth transmission assembly; 93131-Second lead screw; 93132-Second nut; 9314-Fourth guide assembly; 93141-Seventh slider; 93142-Seventh slide rail;

[0074] 941 - Injection needle holder; 942 - Fourth moving assembly;

[0075] 9421-Fifth bracket; 9422-Fifth motor; 9423-Sixth transmission assembly; 94231-Fifth pulley; 94232-Fifth belt; 9424-Fifth transmission assembly; 94241-Third lead screw; 94242-Third nut; 9425-Fifth guide assembly; 94251-Eighth slider; 94252-Eighth slide rail. Detailed Implementation

[0076] The core of this application is to provide a blood pretreatment component, and to provide a blood pretreatment component optimization method and blood pretreatment component with high optimization accuracy and low optimization cost.

[0077] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0078] See Figures 1 to 5 This application discloses a blood pretreatment assembly including a transportable mechanism 1, a blood collection tube loading position 2, a reagent bottle storage position 3, a centrifuge tube loading position 4, a centrifugation position 5, and a cooling module 10. The blood collection tube loading position 2 stores blood collection tubes 100, which are used to hold blood. The reagent bottle storage position 3 stores reagent bottles 200, which are used to hold reagents. The centrifuge tube loading position 4 stores centrifuge tubes 300, which are used to hold a mixture of reagents and blood. The centrifugation position 5 is used to mix the mixture within the centrifuge tubes. The transportable mechanism 1 is used for transporting and / or transferring liquids between the blood collection tube loading position 2, the centrifuge tube loading position 4, and the centrifugation position 5.

[0079] The cooling module 10 includes a cooling component 11 and a heat dissipation component 12; in the first direction z, the cooling component 11 is located below the blood collection tube loading position 2 and / or the reagent bottle storage position 3;

[0080] The heat dissipation component 12 is located at the heat dissipation end of the cooling component 11, and the heat dissipation component 12 includes a sealed cavity 120. A first air inlet 121 is provided on the first side of the sealed cavity 120, a second air inlet 122 is provided on the second side of the sealed cavity 120, and an air outlet 123 is provided on the third side of the sealed cavity 120. The direction of the first air inlet 121 intersects with that of the second air inlet 122, so as to allow air to circulate and replace the air at the corresponding corners from the first air inlet 121 to the air outlet 123.

[0081] In the blood pretreatment component of this application, a cooling module is provided below the blood collection tube loading position 2 and / or the reagent bottle storage position 3. The cooling module includes a refrigeration component 11 and a heat dissipation component 12. The heat dissipation component 12 is arranged at the heat dissipation end of the refrigeration component 11. Since the direction of the first air inlet 121 of the heat dissipation component 12 intersects with the second air inlet 122, the airflow direction from the first air inlet 121 to the corner of the air outlet 123 can be changed to achieve airflow displacement. Therefore, the above mechanism can achieve heat exchange without dead zones, improving the heat dissipation efficiency of the heat dissipation component 12, thereby improving the cooling effect and efficiency of the refrigeration component 11.

[0082] The aforementioned cooling assembly 11 includes a cooling plate 111 and a cooling block 112. The lower surface of the cooling plate 111 serves as the heat dissipation end of the cooling assembly 11 and contacts the heat dissipation assembly 12. The upper surface of the cooling plate 111 is in direct or indirect contact with the cooling block 112. The cooling block 112 is in direct or indirect contact with the blood collection tube loading position 2 and / or the reagent bottle storage position 3. The aforementioned cooling module 10 can be disposed below the blood collection tube loading position 2 and / or the reagent bottle storage position 3. The following description uses the example of the cooling module 10 being disposed below the blood collection tube loading position 2 and the reagent bottle storage position 3.

[0083] The blood collection tube loading position 2 is used to hold the blood collection tubes 100, and the reagent bottle storage position 3 is used to hold the reagents; in the first direction z, the cooling component 11 is located below the placement position; the heat dissipation component 12 is located at the heat dissipation end of the cooling component 11, and the heat dissipation component 12 includes a sealed cavity 120. A first air inlet 121 is provided on the first side of the sealed cavity 120, a second air inlet 122 is provided on the second side of the sealed cavity 120, and an air outlet 123 is provided on the third side of the sealed cavity 120. The direction of the first air inlet 121 intersects with that of the second air inlet 122, so as to allow the air at the corresponding corner from the first air inlet 121 to the air outlet 123 to be circulated and replaced.

[0084] In the cooling module described above, the heat dissipation component 12 is arranged at the heat dissipation end of the cooling component 11. Since the direction of the first air inlet 121 of the heat dissipation component 12 intersects with the second air inlet 122, the airflow direction from the first air inlet 121 to the corner of the air outlet 123 can be changed to achieve airflow displacement. Therefore, the above mechanism can achieve heat exchange without dead zones, improving the heat dissipation efficiency of the heat dissipation component 12, thereby improving the cooling effect and efficiency of the cooling component 11.

[0085] It should be noted that the first direction z corresponds to the height direction of the cooling module, and the second direction x and the third direction y correspond to the width and length directions of the cooling module, respectively. The aforementioned sealing cavity 120 has multiple sides: a top side, a bottom side, a left side, a right side, a front side, and a rear side. The top and bottom sides are arranged opposite each other in the first direction z, with the top side on top; the left and right sides are arranged opposite each other in the second direction y; and the front and rear sides are arranged opposite each other in the second direction x. The first side can be any side other than the top side, and the second side is the side adjacent to the first side, allowing the first air inlet 121 and the second air inlet 122 to intersect. The third side is any side other than the first, second, and top sides. In the figure, the first side is the front side, the second side is the bottom side, and the third side is the rear side. The first side and the third side of the sealing cavity 120 are arranged opposite each other along the second direction x.

[0086] The aforementioned sealed cavity 120 can be formed by one shell or by two shells. In the figure, it is formed by two shells, namely a first shell 124 and a second shell 125. The first shell 124 and the second shell 125 are connected to form the sealed cavity 120, wherein there is a corner in the area where the first shell 124 and the second shell 125 meet.

[0087] Furthermore, the aforementioned cooling block 112 is used to conduct the cooling energy of the cooling plate 111 to the blood collection tube loading position 2 and the reagent bottle storage position 3. Taking the cooling block 112 transmitting the cooling energy to the blood collection tube loading position 2 as an example, the cooling block 112 may include a first cooling block 1121. The upper surface of the first cooling block 1121 is provided with a guide groove 11211 for holding the sample bottle rack. The bottom of the guide groove 11211 contacts the sample bottle on the sample bottle rack to cool the inside of the sample bottle. By setting the guide groove 11211, the sample bottle rack can be installed in a preset direction. The preset direction can be a second direction x or a third direction y. In the figure, the preset direction is the second direction x.

[0088] The number of guide slots 11211 is at least two, and the at least two guide slots 11211 are arranged side by side along the second direction y. Each guide slot 11211 can be used to install one sample bottle rack. The number of guide slots 11211 is at least two, which can increase the number of sample bottle racks, and thus increase the number of sample bottles.

[0089] Taking the transfer of cooling block 112 to reagent bottle storage position 3 as an example, the cooling block 112 includes a second cooling block 1122 and a third cooling block 1123. The second cooling block 1122 is provided with a holding cavity 11231 for holding the reagent bottle 200. The third cooling block 1123 and / or the second cooling block 1122 include a cooling channel 11232 for arranging an output pipeline, which is connected to the reagent bottle 200. It should be explained that the cooling channel 11232 may be arranged only in the second cooling block 1122, or it may also be arranged in the third cooling block 1123, or it may be arranged simultaneously in both the second cooling block 1122 and the third cooling block 1123.

[0090] When the cooling channel 11232 is arranged in both the second cooling block 1122 and the third cooling block 1123, a part of the cooling channel 11232 is formed on the second cooling block 1122, and another part of the cooling channel 11232 is formed on the third cooling block 1123. The two are combined to form the cooling channel 11232.

[0091] Therefore, the second cooling block 1122 comprises two parts, one part of which is provided with a holding cavity 11231, and the other part is fixedly connected to the third cooling block 1123 to form a cooling channel 11232. For ease of observation, the third cooling block 1123 is made of transparent material.

[0092] To optimize volume, the holding cavity 11231 and the cooling channel 11232 are arranged along the second direction x, and the second direction x, the third direction y, and the first direction z are perpendicular to each other. The second cooling block 1122 has an L-shaped structure, and the second cooling block 1122 and the third cooling block 1123 together have a cuboid structure.

[0093] The aforementioned third cooling block 1123 has multiple sides, namely a top side, a bottom side, a left side, a right side, a front side, and a rear side. The top and bottom sides are arranged opposite each other in the first direction z, with the top side at the top. The left and right sides are arranged opposite each other in the third direction y. The front and rear sides are arranged opposite each other in the second direction x. A cooling channel 11232 penetrates the third cooling block 1123. The first end of the cooling channel 11232 is located on the first side of the third cooling block 1123, and the second end of the cooling channel 11232 is located on the second side of the third cooling block 1123. The first and second sides of the third cooling block 1123 are adjacent to or opposite to each other. In the figure, the first side of the third cooling block 1123 is the top side of the third cooling block 1123, and the second side of the third cooling block 1123 is the rear side of the third cooling block 1123.

[0094] The cooling channel 11232 comprises an interconnected first section and a second section. The first end of the first section serves as the first end of the cooling channel 11232, and the second end of the second section serves as the second end of the cooling channel 11232. In some examples, both the first section and the second end can be straight. In some examples, the first section is an arc shape, and the second section is a straight line. The smooth transition between the first and second sections reduces eddies and turbulence. If the direction of the cooling channel 11232 needs to be changed, directly using a sharp right angle or a small-radius bend would cause the reagent to suddenly impact the tube wall, resulting in huge energy loss, eddies, and flow separation. Using an arc (ideally a large-radius arc) first allows the reagent to smoothly and gradually change direction, using most of the kinetic energy to maintain the main flow velocity, significantly reducing head loss. After passing through the first section, the velocity distribution of the reagent becomes turbulent (e.g., high velocity on the outside, low velocity on the inside). The subsequent second section provides a "stabilization zone" for the reagent, allowing the turbulent flow field sufficient time and distance to redevelop into a stable, uniform, and fully developed flow. This is crucial for equipment (such as flow meters and heat exchangers) or processes (such as injection molding) that require a stable flow field.

[0095] It should be explained that the aforementioned placement positions, namely the blood collection tube loading position 2 for holding blood collection tubes 100 and the reagent bottle storage position 3 for holding reagent bottles 200, are arranged side by side along the second direction x or the third direction y. In the figure, the blood collection tube loading position 2 and the reagent bottle storage position 3 are arranged along the third direction y. In order to hold more blood collection tubes 100, the sample bottle rack is relatively long, and the delivery pipeline is also relatively long. By arranging the blood collection tube loading position 2 and the reagent bottle storage position 3 along the third direction y, it is possible to avoid the blood collection tube loading position 2 and the reagent bottle storage position 3 overlapping in the length direction. Instead, the blood collection tube loading position 2 and the reagent bottle storage position 3 are overlapped in the width direction. Therefore, the resulting placement area is not too narrow and long.

[0096] Since the sample bottles and reagent bottles 200 require low-temperature refrigeration, condensation is inevitable during the refrigeration process. To reduce the possibility of condensation leaking into electronic components and causing accidents, in some embodiments of this application, the cooling module 10 further includes a condensate drainage component 13 located below the placement position to collect condensate. The condensate is then discharged once a certain level is reached, or the condensate is directly discharged to a designated component during the collection process.

[0097] See Figure 4 and Figure 5The condensate discharge assembly 13 includes a receiving tray 131, which includes a manifold 132 and a drain outlet 133. The manifold 132 is connected to the drain outlet 133. An outlet is provided at the placement position, which is connected to the manifold 132. It should be explained that the manifold 132 collects the condensate discharged from the outlet, which flows to the drain outlet 133 and is discharged from the receiving tray 131. For example, an external drain pipe can be connected to discharge the condensate to a waste liquid collection tank.

[0098] It should be noted that the aforementioned drip tray 131 can be integrated with the first cooling block 1121, the second cooling block 1122, and the third cooling block 1123, forming a single unit. A manifold 132 and a drain outlet 133 are provided on the overall structure to collect condensate. This integrated design increases the overall integration of the condensate discharge assembly 13 and its placement, reducing the overall size of the equipment. Alternatively, in some examples, the first cooling block 1121, the second cooling block 1122, and the third cooling block 1123 are separate units from the drip tray 131.

[0099] The number of the above-mentioned manifolds 132 is at least two, and the at least two manifolds 132 surround the placement position. In the figure, there are two manifolds 132. One manifold 132 is arranged at the blood collection tube loading position 2, and the other manifold 132 is arranged at the reagent bottle storage position 3, and finally converges at the drain port 133.

[0100] Along the second direction x, the outlet is located in front of or behind the placement position. In the figure, the outlet is located behind the placement position. The sample bottle rack is installed into the guide groove 11211 from front to back along the second direction x. Thus, the outlet is arranged at the rear, which is consistent with the insertion direction of the sample bottle to facilitate drainage.

[0101] The cross-section of the liquid outlet can be square, circular, or semi-circular. In the example disclosed herein, the cross-section of the liquid outlet is semi-circular, with the straight part at the bottom and the arc part at the top.

[0102] The cooling component 11 in this example is a semiconductor refrigeration system. The cooling component 11 includes a cooling plate 111 located below the condensate drain assembly 13 along a first direction z. The upper surface of the cooling plate 111 serves as the cooling end of the cooling component 11 and contacts the condensate drain assembly 13. The lower surface of the cooling plate 111 serves as the heat dissipation end of the cooling component 11 and contacts the heat dissipation assembly 12. The cooling end is used to cool the sample bottles and / or reagent bottles 200 at their placement positions, and the heat dissipation assembly 12 dissipates heat from the heat dissipation end to form a continuous cycle, thereby improving the heat dissipation effect of the cooling component 11.

[0103] To achieve precise temperature control, the refrigeration assembly 11 also includes a temperature control sensor 113, which adjusts the cooling capacity of the refrigeration assembly 11 based on the detection results of the temperature control sensor 113. There are at least two temperature control sensors 113, arranged side-by-side along a third direction y, located between the refrigeration plate 111 and the condensate drain assembly 13.

[0104] To further improve the heat dissipation effect of the cooling assembly 11, the heat dissipation assembly 12 also includes heat dissipation fins 128. The heat dissipation fins 128 are located on the top side inside the sealed cavity 120, and the extending direction of the heat dissipation fins 128 is consistent with the extending direction of the first air inlet 121. By setting the heat dissipation fins 128, the effective heat exchange area of ​​the cooling plate 111 can be increased, thereby improving the heat dissipation effect of the cooling assembly 11.

[0105] The heat dissipation assembly 12 can be either passive or active. In an active heat dissipation scheme, the heat dissipation assembly 12 further includes a first fan 126 and a second fan 127. The first fan 126 is arranged at the first air inlet 121, and the second fan 127 is arranged at the second air inlet 122. When the first fan 126 and the second fan 127 are running, they can force external air into the sealed cavity 120. Since the first air inlet 121 and the second air inlet 122 intersect, they can drive the air in the heat exchange dead zone for forced cooling.

[0106] Combination Figure 1 See Figure 6 and Figure 7The aforementioned transport mechanism is used for transporting and / or pipetting. To improve the transport capacity of the transport mechanism 1, the transport mechanism 1 may include a motion spindle 1a, a first transport mechanism 1b, and a second transport mechanism 1c. Both the first transport mechanism 1b and the second transport mechanism 1c are mounted on the motion spindle 1a to drive the first and second transport mechanisms to move in the second direction x and the third direction y. The first transport mechanism 1b and the second transport mechanism 1c can move in the first direction z to achieve movement towards or away from a target location. The structures of the first transport mechanism 1b and the second transport mechanism 1c may be the same or different. To optimize the volume of the blood pretreatment component of this application, some embodiments of this application employ different structures for the first transport mechanism 1b and the second transport mechanism 1c. The first transport mechanism 1b adopts a single-stage telescopic structure, while the second transport mechanism 1c adopts a multi-stage telescopic structure. Since the area corresponding to the first transport mechanism 1b does not require a large telescopic range, it is not necessary to arrange a multi-stage telescopic structure. However, the area corresponding to the second transport mechanism 1c requires a large telescopic range, so a multi-stage telescopic structure can be arranged for the second transport mechanism 1c. By increasing the transport stroke of the second transport mechanism 1c, its applicability is increased, thereby reducing the height of the entire blood pretreatment assembly in the first direction z, thus improving the compactness of the blood pretreatment assembly.

[0107] See Figure 6 and Figure 7 The second transport mechanism 1c includes a base 101, a drive assembly 102, at least two stages of motion assemblies (not shown), a transport gripper 105, and a pipette 106. The at least two stages of motion assemblies are movably disposed on the base 101 along a first direction. The first-stage motion assembly is drivenly connected to the drive assembly 102 to generate a first-stage displacement. Adjacent motion assemblies are coupled together via belts to generate a last-stage displacement relative to the base 101. The last-stage motion assembly is connected to the transport gripper 105 and / or the pipette 106. The transport gripper 105 is used to hold a centrifuge tube 300 or a sample injection tube 400, and the pipette 106 is used to mount a pipette tip.

[0108] In the second transport mechanism 1c of this application, the drive component 102 drives the motion component located at the first stage to operate and generate a first-stage displacement relative to the base 101. Simultaneously, because adjacent motion components are coupled together by belts, the transmission component located at the last stage generates a last-stage displacement, resulting in at least two stages of extension and retraction of the transport gripper 105 and / or the pipette 106. This increases the transport stroke of the second transport mechanism 1c within a limited space. With the increased transport stroke of the second transport mechanism 1c, the height of the LCMS integrated machine can be reduced.

[0109] The first direction z mentioned above is the extension and retraction direction of the second conveying mechanism 1c. The motion components of this application are at least two-stage. Taking a two-stage motion component as an example, the first-stage motion component can form a first-stage displacement, and the second-stage motion component can form a second-stage displacement. The first-stage motion component corresponds to the initial displacement, and the second-stage motion component corresponds to the final displacement, thus forming two-stage extension and retraction. Taking a three-stage motion component as an example, the first-stage motion component can form a first-stage displacement, the second-stage motion component can form a second-stage displacement, and the third-stage motion component can form a third-stage displacement. The first-stage motion component corresponds to the initial displacement, and the third-stage motion component corresponds to the final displacement, thus forming three-stage extension and retraction.

[0110] The connection relationships between different motion components can be referenced from each other. This application takes the motion components as a two-level example for introduction.

[0111] See Figure 6 and Figure 7 The motion component in this application example includes two levels of motion components, namely a first motion component 103 and a second motion component 104; the first motion component 103 is located at the first level and the second motion component 104 is located at the last level.

[0112] The first motion component 103 includes a first slide rail module 1031, a first pulley 1032, a first belt 1033, and a first slider 1034. The slider 10312 of the first slide rail module 1031 is mounted on the base 101, and the slide rail 10311 of the first slide rail module 1031 is movable relative to the slider 10312 of the first slide rail module 1031. The first pulley 1032 is mounted on the base 101 and is connected to the drive component 102 for transmission. The first belt 1033 is wound around the first pulley 1032. The first slider 1034 is mounted on the slide rail 10311 of the first slide rail module 1031 and fixed on the first belt 1033 to drive the slide rail 10311 of the first slide rail module 1031 to move a first distance.

[0113] When the drive assembly 102 operates in the forward direction, it can drive the first pulley 1032 to rotate along the first rotation direction. During the rotation of the first pulley 1032, it drives the first belt 1033 to rotate, thereby driving the first slider 1034 to move along the first direction. Since the first slider 1034 is connected to the guide rail of the first slide rail module 1031, the guide rail of the first slide rail module 1031 can extend along the first direction. When the drive assembly 102 operates in the reverse direction, it can drive the first pulley 1032 to rotate along the second rotation direction. During the rotation of the first pulley 1032, it drives the first belt 1033 to rotate, thereby driving the first slider 1034 to move along the first direction. Since the first slider 1034 is connected to the guide rail of the first slide rail module 1031, the guide rail of the first slide rail module 1031 can retract along the first direction.

[0114] The number of the aforementioned first pulleys 1032 can be two, with the two first pulleys 1032 arranged along a first direction, one of which serves as the driving pulley and the other as the driven pulley. Thus, the output shaft of the drive assembly 102 can be coaxially arranged with one of the first pulleys 1032.

[0115] In another example of this application, the number of first pulleys 1032 is three, with two first pulleys 1032 arranged as driven pulleys along the first direction, and the remaining first pulley 1032 acting as the driving pulley and connected to the drive assembly 102. This arrangement allows the drive assembly 102, the first pulleys 1032, and the first belt 1033 to be staggered in the second direction, thereby reducing interference from the drive assembly 102 to the first belt 1033. The second direction is perpendicular to the first direction.

[0116] In the diagram, the first motion component 103 also includes two idler pulleys 1035, located on either side of the first pulley 1032, which serves as the drive pulley. By setting the two idler pulleys 1035, the winding direction of the first belt 1033 can be changed, reducing interference to other components caused by the arrangement of the first belt 1033, thus making the entire conveying mechanism more compact. Since the drive component 102 is separated from the load, the mass and inertia of the motion component are effectively reduced, resulting in advantages such as improved system dynamic response speed, reduced load on the drive component 102, and higher positioning accuracy.

[0117] The aforementioned drive assembly 102 may include a motor, which can be arranged on the outside of the base 101. This has the advantages of greatly simplifying the internal structure of the telescopic arm, saving valuable space, and facilitating motor heat dissipation and maintenance.

[0118] Two first pulleys 1032 arranged along a first direction are mounted on a base 101 via pulley brackets. The base 101 has mounting holes that mate with the pulley brackets. The cross-section of the mounting holes can be circular, elongated, or similar. Preferably, the mounting holes are elongated to facilitate adjustment of the positions of the two first pulleys 1032 relative to the base 101, thereby indirectly adjusting the extension and retraction stroke of the conveying mechanism.

[0119] In the diagram, the second motion component 104 includes a second slide rail module 1041, a second pulley 1042, a second belt 1043, a fixing block 1044, a second slider 1045, and a third slider 1046. The slider 10412 of the second slide rail module 1041 is fixed to the slide rail 10311 of the first slide rail module 1031, and the slide rail 10411 of the second slide rail module 1041 is movable relative to the slider 10412 of the second slide rail module 1041; the second belt 1044... Wheel 1042 is mounted on slide rail 10311 of first slide rail module 1031 via second slider 1045; second belt 1043 is wound around second pulley 1042; fixing block 1044 fixes second belt 1043 to base 101; third slider 1046 is fixed on slide rail 10411 of second slide rail module 1041 and fixed on second belt 1043 to drive slide rail 10411 of second slide rail module 1041 to move a second distance.

[0120] As described above, when the drive assembly 102 is running in the forward direction, the guide rail of the first slide rail module 1031 can extend along the first direction. Since the slider 10412 of the second slide rail module 1041 is fixed on the slide rail 10311 of the first slide rail module 1031, the second slide rail module 1041 extends along the slide rail 10311 of the first slide rail module 1031 in the first direction. At the same time, since the second belt 1043 is fixed to the base 101 by the fixing block 1044, the second belt 1043 will generate an inertial force to continue rotating along the first rotation direction, driving the slide rail 10411 of the second slide rail module 1041 to continue extending along the first direction, thereby forming a conveying mechanism. Secondary extension of the arm and / or pipetting arm 10; when the drive assembly 102 is running in reverse, the guide rail of the first slide rail module 1031 can retract along the first direction. Since the slider 10412 of the second slide rail module 1041 is fixed on the slide rail 10311 of the first slide rail module 1031, the second slide rail module 1041 as a whole follows the slide rail 10311 of the first slide rail module 1031 to retract in the first direction. At the same time, since the second belt 1043 is fixed on the base 101 by the fixing block 1044, the second belt 1043 will generate an inertial force to continue rotating along the first rotation direction, driving the slide rail 10411 of the second slide rail module 1041 to continue to retract along the first direction.

[0121] The first motion component 103 and the second motion component 104 described above in this application are coupled together by a belt. This connection is a non-contact power transmission, which has the advantages of buffering and vibration reduction, low operating noise, and low maintenance cost.

[0122] In the diagram, there are two second sliders 1045. One second slider 1045 is arranged close to the first slider 1034, and the other slider is arranged close to the slider 10312 of the first slide rail module 1031. Each of the two second sliders 1045 is equipped with a second pulley 1042.

[0123] In addition, to improve stability during operation, the first slide rail module 1031 and / or the second slide rail module 1041 are double-layer slide rail structures.

[0124] In order to reduce interference during the operation of the first belt 1033 and the second belt 1043, the first belt 1033 and the second belt 1043 are arranged in a staggered manner.

[0125] See Figure 1 In order to facilitate opening and closing the caps of the blood collection tube 100 and / or centrifuge tube 300, the blood pretreatment assembly also includes a cap opening / closing position 8, which is used to open and close the caps of the blood collection tube 100 and / or centrifuge tube.

[0126] In some embodiments, the cover switch 8 includes a first cover switch module 81 and a second cover switch module 82. The first cover switch module 81 is used to open the cover of the blood collection tube 100 transported by the transport mechanism 1 from the blood collection tube loading position 2; the second cover switch module 82 is used to open and close the cover of the centrifuge tube 300 transported by the transport mechanism 1 from the centrifuge tube loading position 4. By setting the first cover switch module 81 and the second cover switch module 82, the cover switch actions of the blood collection tube 100 and the centrifuge tube 300 can be performed independently, thereby reducing the impact of the cover switch actions on subsequent processes and improving the efficiency of pretreatment.

[0127] In addition, the cover switch position 8 also includes a reagent adding module 84, which is used to add reagents to the centrifuge tube 300 located at the second cover switch module 82 after the cover is opened. The reagent adding module 84 can be connected to the reagent bottle 200 of the reagent bottle storage position 3 to add the reagents stored in the reagent bottle 200 to the centrifuge tube.

[0128] The first transport mechanism 1b transports the blood collection tube 100 located at the blood collection tube loading position 2 to the first switch cover module 81 and opens the cover; the first transport mechanism 1b transports the centrifuge tube 300 located at the centrifuge tube loading position 4 to the second switch cover module 82 and opens the cover; the first transport mechanism 1b transfers the blood in the blood collection tube 100 at the first switch cover module 81 to the centrifuge tube 300 at the second switch cover module 82 to perform subsequent processes, such as transporting it to the centrifuge position 5 for mixing.

[0129] Since the centrifuged sample requires further processing, the switch cap position 8 also includes a third switch cap module 83, which is used to open the cap of the mixed centrifuge tube 300 transported by the transport mechanism 1. The mixed centrifuge tube 300 is then transferred to the sample injection tube 400 by the second transport mechanism 1c to form the target solution.

[0130] Combination Figure 1 See Figures 8 to 10 In order to facilitate the formation of the target liquid, this blood pretreatment component also includes a sample injection station 9, which is used to deliver the target liquid to a designated location.

[0131] The injection station 9 includes a sampling module 93 and an injection module 94. The sampling module 93 can draw up the target liquid and discharge the target liquid into the injection module 94. The injection module 94 can deliver the target liquid to a designated location.

[0132] The target liquid sampled by the sampling module 93 can be formed by dilution. In this case, the injection station also includes a fourth cap switch module 92 and a dilution module 95. The fourth cap switch module 92 is used to open the injection tube 400, and the dilution module 95 is used to inject diluent into the opened injection tube 400 to form the target liquid. By setting a separate fourth cap switch module 92, the cap opening and closing time can be shortened.

[0133] To further improve efficiency, the injection station 9 also includes a transfer module 91, which is located on the first side of the fourth switch cap module 92. This module can drive the injection tube 400, transported from the injection tube loading station 7 by the second transport mechanism, to switch between the initial station, the cap opening station, the dilution station, and the sampling station. The fourth switch cap module 92 is located above the cap opening station and can open the cap of the injection tube 400 located at the cap opening station. The dilution module 95 is located above the dilution station and can add diluent to the injection tube 400 located at the dilution station, which is located between the initial station and the cap opening station. The sampling module 93 is located on the second side of the fourth switch cap module 92 and above the sampling station. The sampling module 93 can perform an aspiration action on the injection tube 400 located at the sampling station to aspirate the sample. The sampling module 93 can also move above the injection module 94 and eject the target liquid into the injection module 94. The injection module 94 can transport the sample to a designated location.

[0134] During sample injection, the injection tube 400 moves from the initial station to the cap-opening station and is capped by the fourth cap-opening module 92. After opening, the injection tube 400 moves to the dilution station, where the dilution module 95 adds diluent to the injection tube 400 to dilute the sample. Then, the transfer module 91 delivers the injection tube 400 to the sampling station, where the sampling module 93 takes a sample. The sampling module 93 moves above the injection module 94 and dispenses the sample into the injection module 94, which then transports the sample to the designated location. Because the injection station 9 in this embodiment includes an independent cap-opening module to open the injection tube 400 and the dilution module 95 to dilute the sample before injection, the sample concentration before injection can be reduced, thereby reducing the risk of cross-contamination.

[0135] It should be noted that the sample contained in the injection tube varies at different stations. Taking blood testing as an example, the injection tube at the initial station contains the separated supernatant; the injection tube at the dilution station contains only the separated supernatant before adding diluent, and a mixture of supernatant and diluent after adding diluent; the injection tube at the sampling station contains a mixture of supernatant and diluent. Therefore, the sampling module 93 samples a mixture of supernatant and diluent (target solution), and the sample it ejects is a mixture of supernatant and diluent. The above example only uses blood testing. This injection mechanism can also be used for the injection of biological and non-biological samples. Biological samples may include, for example, urine, saliva, cerebrospinal fluid, tissue samples, hair, dried blood spots, etc.; non-biological samples may include, for example, environmental samples (water samples, soil / sediment), food and agricultural products (pesticide residues, veterinary drug residues, etc.), pharmaceuticals and preparations. In addition, it can also be used for the injection of microorganisms, single-cell analysis, etc.

[0136] Furthermore, in this embodiment, the parallel operation of the transfer module 91, the fourth switch cover module 92, the dilution module 95, the sampling module 93, and the injection module 94 in the injection position 9 can save time. When the fourth switch cover module 92 performs the opening action, it will not affect the operation of the dilution module 95. The transfer module 91 is located on the first side of the fourth switch cover module 92, and the sampling module 93 and the injection module 94 are located on the second side of the fourth switch cover module 92. They are arranged alternately during operation, which can save 400 injection tubes and reduce pressure loss.

[0137] It should be explained that the injection station 9 of this application has a second direction x, a third direction y, and a first direction z, wherein the first direction z corresponds to the height direction. The initial station is the initial position where the injection tube 400 is placed in the sampling mechanism; the capping station is the position where the capping action of the injection tube 400 is performed; the dilution station is the station where the dilution action of the injection tube 400 is performed; the sampling station is the station where the sampling action of the injection tube 400 is performed; and the injection station is the station where the sample is transported to the designated position. The above-mentioned sampling station and injection station are located on the second side of the capping station, so the execution of the sampling action and the injection action will not be affected when the capping action is performed.

[0138] Combination Figure 7 See Figure 8 The transfer module 91 in this application is located on the first side of the fourth switch cap module 92, and can drive the sample vial to switch between the initial station, the cap opening station, the dilution station, and the sampling station. The transfer module 91 may include a first guide rail module 911, a second guide rail module 912, and a tube clamp 913. The first guide rail module 911 extends along a third direction y; the second guide rail module 912 extends along a second direction y. The fixed end of the second guide rail module 912 is disposed at the sliding end of the first guide rail module 911. The sliding end of the second guide rail module 912 is connected to the tube clamp 913 to drive the tube clamp 913 to move along the third direction y between the dilution station and the sampling station. The tube clamp 913 is used to install the injection tube 400 clamp; the second direction x is perpendicular to the third direction y.

[0139] The aforementioned first guide rail module 911 and / or second guide rail module 912 can be a lead screw and nut mechanism, a linear motor guide rail module, etc. The sliding end of the first guide rail module 911 can move along the second direction x. Since the fixed end of the second guide rail module 912 is located at the sliding end of the first guide rail module 911, the second guide rail module 912 as a whole can move along the third direction y. The sliding end of the second guide rail module 912 can move along the third direction y. The pipe clamp 913 is installed at the sliding end of the second guide rail module 912, so the pipe clamp 913 can move along the third direction y.

[0140] See Figure 8The second guide rail module 912 includes a first bracket 9121, a first motor 9122, a first transmission assembly 9123, a first guide assembly 9124, and a push rod 9125. The first bracket 9121 extends along the third direction y and is arranged at the sliding end of the first guide rail module 911. The first motor 9122 is mounted on the first bracket 9121 and is connected to the first transmission assembly 9123. The push rod 9125 is connected to the first transmission assembly 9123. A pipe clamp 913 is mounted on the push rod 9125. The first guide assembly 9124 connects the first bracket 9121 and the first transmission assembly 9123 respectively, so that the push rod 9125 moves in the third direction y. The push rod 9125 has a first position and a second position. When the push rod 9125 is in the first position, the second guide rail module 912 moves along the third direction y, which can drive the tube clamp 913 to switch between the initial station, the opening station, and the dilution station. When the push rod 9125 is in the second position, the tube clamp 913 moves along the third direction y, which can push the tube clamp 913 to the sampling station.

[0141] The function of the first transmission component 123 is to convert the rotational motion of the first motor 122 into the linear motion of the push rod 9125. For example, it can be a belt drive structure, a screw and nut drive structure, etc. When the first transmission component 9123 is a belt drive structure, it includes a third belt 91231 and a third pulley 91232. The third pulley 91232 is mounted on the first bracket 9121, and the third belt 91231 is wound around the third pulley 91232. There are at least two third pulleys 91232, arranged along a third direction y, so that a portion of the third belt 1231 is arranged along the third direction y. The push rod 9215, located in this area, can then reciprocate along the third direction y. The first transmission component 123 in this application example, using a belt drive structure, has the following advantages: the belt is typically made of lightweight, high-strength materials (such as polyurethane, rubber, and steel wire rope), the pulley has low inertia, and the overall system movement mass is light. Therefore, very high linear motion speeds (up to 10 m / s and above) and extremely high start-stop acceleration can be achieved, far exceeding ball screws of the same cost level. The belt is a continuous flexible body, and its theoretical achievable stroke length mainly depends on the belt manufacturing length and support structure, easily achieving strokes of several meters or even tens of meters. In long-stroke applications, the cost is far lower than that of precision ball screws or linear motors of the same stroke, the structure is simple, and installation requirements are relatively low. The belt-pulley meshing is flexible, resulting in smooth operation and significantly less noise and vibration than gears and racks. It requires no lubrication (or only minimal maintenance), is pollution-free, and is ideal for clean environments (such as food, pharmaceutical, and electronic assembly) and quiet environments. Its simple structure and flexible installation and layout allow the belt to bend and twist (requiring special design) to achieve non-linear or complex path transmission, something difficult to achieve with rigid transmission components. Unlike ball screws, which have a "critical speed" limitation, it will not become unstable due to resonance at ultra-high speeds. Backlash can be largely eliminated by pre-tensioning or using a synchronizing belt, achieving precise synchronous motion.

[0142] The first guide assembly 9124 restricts the pipe clamp 913 to reciprocate only along a third direction y. In some examples, the first guide assembly 9124 may include a fourth slider 91241 and a fourth slide rail 91242. The fourth slider 91241 is fixed on the third belt 91231 to move along the third direction y. A push rod 9125 is fixed on the fourth slider 91241, and the pipe clamp 913 is disposed on the push rod 9127. The fourth slide rail 91242 extends along a second direction y and is disposed on the first bracket 9121, and slides in cooperation with the fourth slider 91241. When the first motor 9122 operates, it drives the third pulley 91232 and the third belt 91231 to operate. The fourth slider 91241 located on the third belt 91231 can move along the third direction y, thereby enabling the pipe clamp 913 to move in the third direction y.

[0143] The push rod 9125 has a first position and a second position. When the push rod 9125 is in the first position, the second guide rail module 912 moves along the third direction y, which can drive the tube clamp 913 to switch between the initial station, the opening station, and the dilution station. When the push rod 9125 is in the second position, the tube clamp 913 moves in the second direction y, which can push the tube clamp 913 to the sampling station.

[0144] To enhance safety, both the first guide rail module 911 and the second guide rail module 912 may be provided with a housing to protect the internal structure of the first guide rail module 911 and the second guide rail module 912. The housing is provided with corresponding guide grooves to accommodate the movement of the pipe clamp 913 or the pipe seat 925.

[0145] By setting the transfer module 91, the diluted sample tube 400 can be pushed to the sampling station, realizing the separation of the cap opening action and the sampling action. This can save the situation where the cap opening station is occupied due to the sampling action, thereby improving efficiency.

[0146] Figure 1 In the middle, the first switch cover module 81, the second switch cover module 82, the third switch cover module 83 and the fourth switch cover module 92 are arranged side by side along the third direction y.

[0147] The first switch cover module 81, the second switch cover module 82, the third switch cover module 83, and the fourth switch cover module 92 have the same structure. Taking the fourth switch cover module 92 located at the sample inlet 9 as an example, combined with... Figure 8 See Figure 9 The function of the fourth cap-opening module 92 in this embodiment is to perform the cap-opening action to open the cap of the sample inlet tube 400. As shown in the figure, the fourth cap-opening module 92 includes a first moving component 921, a second moving component 922, a cap-opening gripper 923, a bottle body gripper 924, and a tube seat 925. The first moving component 921 extends along the second direction x, and the moving end of the first moving component 921 is connected to the tube seat 925 so that the tube seat 925 moves between the initial station and the cap-opening station along the second direction x. The tube seat 925 is used to install the sample inlet tube 400. The second moving component 922 extends along the first direction z, and the moving end of the second moving component 922 is connected to the cap-opening gripper 923 so as to drive the cap-opening gripper 923 to move in the first direction z. The first direction z, the second direction x, and the third direction y are perpendicular to each other.

[0148] The injection tube 400 located at the tube seat 925 can be moved from the initial position to the capping station under the drive of the first moving component 921 and is held by the bottle body gripper 924; the second moving component 922 drives the capping gripper 923 to move downward and perform the capping action. After the cap is opened, the second moving component 922 drives the capping gripper 923 to move upward; the injection tube 400 with the cap opened moves to the dilution station under the drive of the first moving component 921 and the dilution module 95 injects diluent into the injection tube 400.

[0149] The aforementioned first moving component 921 and / or second moving component 922 include a lead screw and nut mechanism, a linear motor guide rail module, etc.

[0150] In the figure, the first moving component 921 includes a second support 9211, a second motor 9212, a second transmission component 9213, and a second guide component 9214. The second support 9211 extends along the second direction x. The second motor 9212 is mounted on the second support 9211 and is connected to the second transmission component 9213. The tube seat 925 is mounted on the second transmission component 9213. The second guide component 9214 connects the second support 9211 and the second transmission component 9213 respectively, so that the tube seat 925 can move in the second direction x.

[0151] The function of the aforementioned second transmission assembly 9213 is to convert the rotational motion of the second motor 9212 into the linear motion of the tube seat 925 along the second direction x. For example, it can be a belt drive structure, a lead screw and nut drive structure, etc. When the second transmission assembly 9213 is a belt drive structure,

[0152] The second transmission assembly 9213 may include a fourth belt 92131 and a fourth pulley 92132. The second motor 9212 is connected to the fourth pulley 92132. The fourth pulley 92132 is mounted on the second bracket 9211, and the fourth belt 92131 is wound around the fourth pulley 92132. There are at least two fourth pulleys 92132, arranged along the second direction x, such that a portion of the fourth belt 92131 is arranged along the second direction x. The tube seat 925 located in this portion can then reciprocate along the second direction x. As described above regarding the first transmission assembly 9123, the second transmission assembly 9213 in this example, employing a belt drive structure, has similar advantages. Furthermore, because the second transmission assembly 9213 in this example is a belt drive structure, it has the advantage of high mechanical precision in transmission, meaning there is no "step loss" during transmission. The second motor 9212 can be a stepper motor. Combining the high mechanical precision of the second transmission component 9213, the transmission distance of the second transmission component 9213 can be precisely controlled by adjusting the step number of the second motor 9212. In this process, no additional displacement sensor is required to achieve accurate transmission. Of course, when even more precise transmission is needed, a displacement sensor can be used for auxiliary control, but this will not be described in detail here.

[0153] The second guide assembly 9214 restricts the tube seat 925 to reciprocate only along the second direction x. The second guide assembly 9214 includes a fifth slider 92141 and a fifth slide rail 92142. The fifth slider 92141 is fixed to the fourth belt 92131 to move along the second direction x. The tube seat 925 is disposed on the fifth slider 92141. The fifth slide rail 92142 extends along the second direction x and is arranged on the second bracket 9211, slidingly engaging with the fifth slider 92141. When the second motor 9212 operates, it drives the fourth pulley 92132 and the fourth belt 92131. The fifth slider 92141, located on the fourth belt 92131, can move along the second direction x, thereby enabling the tube seat 925 to move in the second direction x.

[0154] The capping gripper 923 and / or the bottle body gripper 924 are electric grippers. When the injection tube 400 moves to the capping station, the bottle body gripper 924 holds the injection tube 400; the capping gripper 923 performs the capping action.

[0155] The aforementioned initial station, lid-opening station, and dilution station are located on the first moving component 921, or in some examples, the aforementioned initial station, lid-opening station, and dilution station are located on the second guide rail module 912. In the example of this application, the initial station, lid-opening station, and dilution station are located on the first moving component 921.

[0156] The aforementioned second moving component 922 includes a third support 9221, a third motor 9222, a third transmission component 9223, and a third guide component 9224. The third support 9221 extends along a third direction z. The third motor 9222 is mounted on the third support 9221 and is connected to the third transmission component 9223. The opening gripper 923 is mounted on the third transmission component 9223 to drive the opening gripper 923 to move along the third direction z. The third guide component 9224 is positioned between the third support 9221 and the third transmission component 9223. When the third motor 9222 operates, it drives the third transmission component 9223 to move, allowing the opening gripper 923 located on the third transmission component 9223 to move along the third direction z.

[0157] The function of the aforementioned third transmission component 9223 is to convert the rotational motion of the third motor 9222 into the linear motion of the opening gripper 923. For example, it can be a belt drive structure, a lead screw and nut drive structure, etc. When the third transmission component 9223 is a lead screw and nut drive structure, it includes a first lead screw 92231 and a first nut 92232. The third support 9221 extends along the first direction z. The third motor 9222 is mounted on the third support 9221 and is drive-connected to the first lead screw 92231. The first nut 92232 is drive-connected to the first lead screw 92231.

[0158] The third guide assembly 9224 may include a sixth slider 92241 and a sixth slide rail 92242. The sixth slide rail 92241 extends along the first direction z and is arranged on the third bracket 9221, and slides in cooperation with the sixth slider 92241. When the third motor 9222 operates, it drives the first lead screw 92231 and the first nut 92232 to move. The sixth slider 92241 located on the first nut 92232 can move along the first direction z, thereby enabling the cover-opening gripper 923 to move in the first direction z.

[0159] The dilution module 95 is located on the first side of the fourth switch cover module 92. The dilution module 95 includes an injection head, through which diluent is injected into the sample inlet tube 400 located at the dilution station.

[0160] See the diagram for reference. Figure 9The sampling module 93 is located on the second side of the fourth switch cover module 92 and is used for sampling. The sampling module 93 includes a third moving component 931, a sampling needle 932, and a sampling tube 933. The third moving component 931 extends along the first direction z, and the moving end of the third moving component 931 is connected to the sampling needle 932 to drive the sampling needle 932 to move in the first direction z. The sampling tube 933 is connected to the sampling needle 932 to perform sampling and dispensing actions. The sampling station is located below the sampling needle 932. The transfer module 91 pushes the diluted injection tube 400 to the sampling station. The third moving component 931 operates, and the sampling needle 932 moves towards the injection tube 400. When the sampling needle 932 is inserted into the injection tube 400, the sampling action is performed. After sampling is completed, the third moving component 931 drives the sampling needle 932 upward.

[0161] The injection module 94 is located on one side of the sampling module 93, and the injection module 94 includes an injection needle holder 941. After sampling is completed, the sampling needle 932 moves above the injection module 94 and moves closer to the injection module 94. When the sampling needle 932 is inserted into the injection needle holder 941, the sampling module 93 performs a sample ejection action.

[0162] To facilitate sample injection, the sample injection module 94 of this application further includes a fourth moving component 942, which extends along the second direction y. The moving end of the fourth moving component 942 is disposed on the fourth support 9311 to drive the fourth support 9311 to move along the second direction y. The sample injection needle seat 941 is disposed on the fifth support 9421 to form a sample injection station.

[0163] The aforementioned third moving component 931 and / or fourth moving component 942 are lead screw and nut mechanisms.

[0164] The aforementioned third moving component 931 includes a fourth support 9311, a fourth motor 9312, a fourth transmission component 9313, and a fourth guide component 9314. The fourth support 9311 extends along a first direction z. The fourth motor 9312 is mounted on the fourth support 9311 and is connected to the fourth transmission component 9313. The sampling needle 932 is mounted on the fourth transmission component 9313. The fourth guide component 9314 is positioned between the fourth support 9311 and the fourth transmission component 9313. When the fourth motor 9312 operates, it drives the fourth transmission component 9313 to move along the first direction z, thereby enabling the sampling needle 932 to move along the first direction z.

[0165] The function of the aforementioned fourth transmission component 9313 is to convert the rotational motion of the fourth motor 9312 into the linear motion of the sampling needle 932 in the first direction z. For example, it can be a belt drive structure, a lead screw and nut drive structure, etc. When the fourth transmission component 9313 is a lead screw and nut drive structure...

[0166] The aforementioned fourth transmission assembly 9313 may include a second lead screw 93131 and a second nut 93132. A fourth bracket 9311 extends along a first direction z. A fourth motor 9312 is mounted on the fourth bracket 9311 and is driven by the second lead screw 93131. The second nut 93132 is driven by the second lead screw 93113. The fourth guide assembly 9314 may include a seventh slider 93141 and a seventh slide rail 93142. The seventh slide rail 93142 extends along the first direction z and is mounted on the fourth bracket 9311, and slides in cooperation with the seventh slider 93141. When the fourth motor 9312 operates, it drives the second lead screw 93131 and the second nut 93132. The seventh slider 93141, located on the second nut 93132, can move along the first direction z, thereby enabling the sampling needle 932 to move in the first direction z. The fourth motor 9312 can directly or indirectly drive the second lead screw 93131.

[0167] The aforementioned fourth moving component 942 includes a fifth support 9421, a fifth motor 9422, a fifth transmission component 9424, and a fifth guide component 9425. The fifth support 9421 extends along the first direction z. The fifth motor 9422 is mounted on the fifth support 9421 and is connected to the fifth transmission component 9424. The fifth guide component 9425 is positioned between the fifth support 9421 and the fourth support 9311. When the fifth motor 9422 operates, it drives the fifth transmission component 9424 to move along the first direction z, thereby enabling the sampling needle 932 to move along the first direction z.

[0168] The function of the aforementioned fifth transmission component 9424 is to convert the rotational motion of the fifth motor 9422 into the linear motion of the sampling needle 932 in the first direction z. For example, it can be a belt drive structure, a lead screw and nut drive structure, etc. When the fifth transmission component 9424 is a lead screw and nut drive structure...

[0169] The aforementioned fifth transmission assembly 9424 may include a third lead screw 94241 and a third nut 94242. The fifth bracket 9421 extends along the first direction z. The fifth motor 9422 is driven by the third lead screw 94241. The third nut 94242 is driven by the third lead screw 94241. The fifth guide assembly 9425 may include an eighth slider 94251 and an eighth slide rail 94252. The eighth slide rail 94252 extends along the second direction y and is arranged on the fifth bracket 9421, and slides in cooperation with the eighth slider 94251. When the fifth motor 9422 operates, it drives the third lead screw 94241 and the third nut 94242 to operate. The eighth slider 94251 located on the third nut 94242 can move along the first direction z, thereby enabling the sampling needle 932 to move in the first direction z. The fifth motor 9422 is directly or indirectly driven by the third lead screw 94241. In the case of indirect drive, the fourth moving component 942 also includes a sixth transmission component 9423, which can be a gear transmission structure, a belt transmission structure or a chain transmission structure.

[0170] When the sixth transmission assembly 9423 is a belt drive structure, it may include a fifth pulley 94231 and a fifth belt 94232. The power of the fourth motor 9312 is transmitted to the third lead screw 94241 via the fifth pulley 94231 and the fifth belt 94232. By setting the sixth transmission assembly 9423, the arrangement position of the fifth motor 9422 can be adjusted, resulting in a smaller overall footprint.

[0171] In addition, the injection station 9 in the above example of this application also includes a transport arm, which is used to transport the injection tube 400 to the initial station and to transport the injection tube 400 from the initial station to the dilution station.

[0172] See Figure 1 The centrifuge position 5 in the figure includes a centrifuge 51 and a storage box 52. The centrifuge 51 is used to perform a mixing action on the centrifuge tubes after they are closed, which are transported from the second cover module 82 by the second transport mechanism. The storage box is used to store pipette tips that are compatible with the first transport mechanism and the second transport mechanism.

[0173] The following is an overview of the specific steps involved in the blood pretreatment process:

[0174] 1) The first transport mechanism transports the blood collection tube 100 on the blood collection tube loading position 2 to the first switch cover module 81 and opens the cover;

[0175] 2) The first conveying mechanism moves the centrifuge tube 300 on the centrifuge tube loading position 4 to the second switch cover module 82 and opens the cover;

[0176] 3) The first transport mechanism transfers the sample from the blood collection tube 100 at the first switch cover module 81 into the centrifuge tube 300 at the second switch cover module 82, and the reagent addition module 84 adds reagent to the centrifuge tube 300 at the second switch cover module 82.

[0177] 4) The second transport mechanism places the eight centrifuge tubes 300 containing the samples from the second switch cover module 82 to the centrifuge position 5 for mixing.

[0178] 5) After being mixed, the centrifuge tube 300 is transported and centrifuged by the second transport mechanism and then temporarily stored at position 6 to stand.

[0179] 6) The centrifuge tubes 300, after being left to stand, are moved by the second conveying mechanism to the third switch cover module 83 and the cover is opened;

[0180] 7) The sample inlet tube 400 located at the material loading position 7 of the sample inlet tube is transported by the second conveying mechanism to the fourth switch cover module 92;

[0181] 8) The second transport mechanism extracts the supernatant from the centrifuge tube 300 located at the third switch cover module 83 and transfers it to the sample inlet tube 400 located at the fourth switch cover module 92; the dilution module 95 injects diluent into the sample inlet tube 400 containing the supernatant.

[0182] 9) The transfer module 91 pushes the injection tube 400 containing the diluent to the sampling module 93;

[0183] 10) The sampling module 93 extracts the liquid in the transplanting module 91 and spits it into the injection module 94, and then transports it for testing.

[0184] This application also discloses an integrated LCMS system, including a blood pretreatment component and a chromatography-mass spectrometry analysis module, as described above. Since the blood pretreatment component has the aforementioned effects, the integrated LCMS system including the blood pretreatment component has corresponding effects, which will not be elaborated further here.

[0185] The terms "first" and "second," etc., in the specification, claims, and accompanying drawings of this application are used to distinguish different objects, not to describe a specific order. Furthermore, the terms "comprising" and "having," and any variations thereof, are intended to cover non-exclusive inclusion. For example, a process, method, system, product, or apparatus that includes a series of steps or units may include steps or units not listed, but rather not listed.

[0186] The above description of the disclosed embodiments enables those skilled in the art to make or use this application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of this application. Therefore, this application is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A blood pretreatment component, characterized in that, This includes a handling mechanism, a blood collection tube loading station, a reagent bottle storage station, a centrifuge tube loading station, a centrifugation station, and a cooling module, among which: The material loading position of the blood collection tube is used to store the blood collection tubes, and the blood collection tubes are used to hold blood. The reagent bottle storage compartment is used to store reagent bottles, and the reagent bottles are used to hold reagents; The material level on the centrifuge tube is used to store the centrifuge tube, and the centrifuge tube is used to hold the mixture of the reagent and blood; The transport mechanism is used for transporting and / or transferring liquid between the material loading point on the blood collection tube, the material loading point on the centrifuge tube, and the centrifuge position; The cooling module includes a refrigeration component and a heat dissipation component; in a first direction, the refrigeration component is located below the blood collection tube loading position and / or the reagent bottle storage position; the heat dissipation component is located at the heat dissipation end of the refrigeration component, and the heat dissipation component includes a sealed cavity, a first air inlet is provided on a first side of the sealed cavity, a second air inlet is provided on a second side of the sealed cavity, and an air outlet is provided on a third side of the sealed cavity. The direction of the first air inlet intersects with that of the second air inlet, so as to allow air to circulate and replace at the corresponding corner from the first air inlet to the air outlet.

2. The blood pretreatment component as described in claim 1, characterized in that, The refrigeration assembly includes a refrigeration plate and a cooling block. The lower surface of the refrigeration plate serves as the heat dissipation end of the refrigeration assembly and is in contact with the heat dissipation assembly. The upper surface of the refrigeration plate is in direct or indirect contact with the cooling block. The cooling block is in direct or indirect contact with the blood collection tube loading position and the reagent bottle storage position.

3. The blood pretreatment component as described in claim 1, characterized in that, The blood pretreatment assembly also includes a switch cover position for opening and closing the caps on the blood collection tubes and / or the centrifuge tubes.

4. The blood pretreatment component as described in claim 3, characterized in that, The switch cover position includes a first switch cover module and a second switch cover module. The first switch cover module is used to perform an opening action on the blood collection tubes transported by the transport mechanism from the blood collection tube loading position. The second switch cover module is used to perform an opening and closing action on the centrifuge tubes transported by the transport mechanism from the centrifuge tube loading position.

5. The blood pretreatment component as described in claim 4, characterized in that, The switch cover position also includes a reagent adding module, which is used to add reagents to the centrifuge tube located at the second switch cover module after the cover is opened.

6. The blood pretreatment component as described in claim 5, characterized in that, in, The switch cover position also includes a third switch cover module, which is used to open the cover of the mixed centrifuge tube that is transported from the material position of the centrifuge tube by the conveying mechanism.

7. The blood pretreatment component as claimed in claim 1, characterized in that, The blood pretreatment component also includes a sample inlet for delivering the target fluid to a designated location.

8. The blood pretreatment component as described in claim 7, characterized in that, The injection station includes a sampling module and an injection module. The sampling module can draw up the target liquid and discharge the target liquid into the injection module. The injection module can deliver the target liquid to a designated location.

9. The blood pretreatment component as described in claim 8, characterized in that, The injection station also includes a fourth switch cap module and a dilution module. The fourth switch cap module is used to open the injection tube, and the dilution module is used to inject diluent into the opened injection tube to form the target solution.

10. The blood pretreatment assembly as claimed in claim 9, characterized in that, The injection station also includes a transfer module, which is located on the first side of the fourth switch cap module and can drive the injection tube to switch between the initial station, the cap opening station, the dilution station and the sampling station. The fourth switch cover module is located above the cover opening station and is capable of opening the sample tube located at the cover opening station. The dilution module is located above the dilution station and can add diluent to the injection tube located at the dilution station, wherein the dilution station is located between the initial station and the capping station; The sampling module is located on the second side of the fourth switch cover module and above the sampling station. The sampling module can perform an aspiration action on the sample inlet tube located at the sampling station to aspirate the target liquid; and the sampling module can move above the sample inlet module and eject the target liquid into the sample inlet module. The injection module can deliver the target liquid to a designated location.

11. The blood pretreatment assembly as claimed in claim 9, characterized in that, The fourth cap opening module includes a first moving component, a second moving component, a cap opening gripper, a bottle body gripper, and a tube seat. The first moving component extends along a third direction, and the moving end of the first moving component is connected to the tube seat so that the tube seat moves between the initial station and the cap opening station along a third direction. The tube seat is used to install sample bottles. The second moving component extends along the first direction, and the moving end of the second moving component is connected to the opening gripper to drive the opening gripper to move in the first direction.

12. The blood pretreatment assembly as claimed in claim 11, characterized in that, The transplanting module includes a first guide rail module, a second guide rail module, and a pipe clamp. The first guide rail module extends along the second direction; The second guide rail module extends along a third direction, and the fixed end of the second guide rail module is disposed at the sliding end of the first guide rail module. The sliding end of the second guide rail module is connected to the tube clamp to drive the tube clamp to move between the dilution station and the sampling station along a third direction. The tube clamp is used to install the injection tube clamp. The first direction and the second direction are perpendicular to the third direction.

13. The blood pretreatment assembly as claimed in claim 12, characterized in that, The second guide rail module includes a first bracket, a first motor, a first transmission assembly, a first guide assembly, and a push rod. The first bracket extends along a third direction and is located at the sliding end of the first guide rail module. The first motor is mounted on the first bracket and is connected to the first transmission assembly. The push rod is connected to the first transmission assembly. The tube clamp is mounted on the push rod. The first guide assembly connects the first bracket and the first transmission assembly to allow the push rod to move in a third direction.

14. The blood pretreatment assembly as claimed in claim 13, characterized in that, The dilution station is located on the first moving component, and the dilution module includes an injection head, through which diluent is injected into the sample inlet tube located at the dilution station.

15. The blood pretreatment assembly as claimed in claim 14, characterized in that, The sampling module includes a third moving component, a sampling needle, and a sampling tube. The third moving component extends along a first direction, and the moving end of the third moving component is connected to the sampling needle to drive the sampling needle to move in the first direction. The sampling tube is connected to the sampling needle to perform sampling and dispensing actions. The sampling station is located below the sampling needle.

16. The blood pretreatment assembly as claimed in claim 15, characterized in that, The injection module further includes a fourth moving component, which extends along a third direction. The moving end of the fourth moving component is connected to the third moving component to drive the third moving component to move along the third direction. The injection needle holder is disposed at the fixed end of the fourth moving component to form an injection station.

17. The blood pretreatment assembly as claimed in claim 1, characterized in that, The conveying mechanism includes a motion spindle, a first conveying mechanism, and a second conveying mechanism. Both the first and second conveying mechanisms are mounted on the motion spindle to drive the first and second conveying mechanisms to move in a second and a third direction. The first and second conveying mechanisms are capable of moving in the first direction.

18. The blood pretreatment assembly as claimed in claim 17, characterized in that, The second transport mechanism includes a base, a drive assembly, at least two stages of motion assemblies, transport grippers, and a pipette. The at least two stages of motion assemblies are movably mounted on the base along a first direction. The first-stage motion assembly is drivenly connected to the drive assembly to generate a first-stage displacement. Adjacent motion assemblies are coupled together via belts to generate a last-stage displacement. The last-stage motion assembly is connected to the transport grippers and / or the pipette. The transport grippers are used to hold centrifuge tubes or sample tubes, and the pipette is used to mount pipette tips.

19. The blood pretreatment assembly as claimed in claim 18, characterized in that, The motion component includes two levels of motion components, namely a first motion component and a second motion component; the first motion component is located in the first level, and the second motion component is located in the last level; The first motion component includes a first slide rail module, a first pulley, a first belt, and a first slider. The slider of the first slide rail module is disposed on the base, and the slide rail of the first slide rail module is movable relative to the slider of the first slide rail module. The first pulley is disposed on the base and is connected to the drive component for transmission. The first belt is wound around the first pulley. The first slider is disposed on the slide rail of the first slide rail module and fixed to the first belt to drive the slide rail of the first slide rail module to move a first distance. The second motion component includes a second slide rail module, a second pulley, a second belt, a fixing block, a second slider, and a third slider. The slider of the second slide rail module is fixed on the slide rail of the first slide rail module, and the slide rail of the second slide rail module is movable relative to the slider of the second slide rail module. The second pulley is mounted on the slide rail of the first slide rail module via the second slider. The second belt is wound around the second pulley. The fixing block fixes the second belt to the base. The third slider is fixed on the slide rail of the second slide rail module and on the second belt to drive the slide rail of the second slide rail module to move a second distance.

20. The blood pretreatment assembly as claimed in claim 19, characterized in that, The centrifugation station includes a centrifuge and a storage box. The centrifuge is used to perform a mixing action on the centrifuge tubes after they have been closed, which are transported from the second cover module by the second transport mechanism. The storage box is used to store pipette tips that are compatible with the first transport mechanism and the second transport mechanism.

21. An LCMS all-in-one machine, characterized in that, It includes the blood pretreatment component and the chromatography-mass spectrometry analysis component as described in any one of claims 1-20.

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