Transparent medical dressing with hydration effect as well as preparation method and application of transparent medical dressing

Abstract

The invention discloses a transparent medical dressing with hydration, which comprises polyamide 6 and ethyl laurate, and the mass ratio of the polyamide 6 to the ethyl laurate is (1-3): 20. The invention further discloses a preparation method and application of the transparent medical dressing with the hydration effect, ethyl laurate and polyamide 6 are blended, and due to the addition of ethyl laurate, a moist environment can be provided, pain can be reduced, wound healing can be promoted, and infection can be effectively prevented; the medical nanofiber dressing is prepared through an electrostatic spinning technology, so that the air permeability and the antibacterial property of the dressing are improved. The prepared medical dressing has good air permeability, transparency and antibacterial property, and is suitable for dressing treatment of wounds such as wounds, burns, ulcers, surgical incisions and the like.

Description

Technical Field

[0001] This invention relates to the field of medical dressings, and in particular to a transparent medical dressing with hydration properties, its preparation method, and its application. Background Technology

[0002] While there are many types of medical dressings available, wound care still faces challenges such as slow wound healing, inconvenient dressing changes, and wound infection. Traditional dressings, such as gauze and tape, often have poor breathability and lack sufficient moisture to promote wound healing.

[0003] Existing transparent dressings are often made of synthetic materials such as polyurethane or polyethylene. Although they have good breathability and transparency, they may not be able to effectively provide the wound with the necessary hydration during the wound healing process, thus affecting the healing effect.

[0004] Therefore, there is an urgent need for a new type of medical dressing that is both transparent and can effectively promote wound healing. Summary of the Invention

[0005] In order to overcome the shortcomings of the existing technology, the purpose of this invention is to provide a transparent medical dressing with hydration function, which provides the hydration required for the wound.

[0006] Another object of the present invention is to provide a method for preparing a transparent medical dressing with hydration function.

[0007] Another object of the present invention is to provide an application of a transparent medical dressing with hydration properties.

[0008] The objective of this invention is achieved through the following technical solution:

[0009] A transparent medical dressing with hydration properties comprises polyamide 6 and ethyl laurate, wherein the mass ratio of polyamide 6 to ethyl laurate is 1 to 3:20.

[0010] A method for preparing a transparent medical dressing with hydration properties, the specific steps of which are as follows:

[0011] (1) Weigh out polyamide 6 and dissolve it in the mixed solvent, stir for 6-8 hours until a uniform and transparent solution is formed;

[0012] (2) Add ethyl laurate and stir continuously to ensure uniform dispersion to obtain the spinning solution;

[0013] (3) The spinning solution is loaded into a syringe and electrospinned by a high voltage electric field. The nanofibers are deposited on the collecting plate to form a nanofiber nonwoven film.

[0014] (4) The obtained nanofiber nonwoven membrane is vacuum dried to obtain a transparent medical dressing with hydration function.

[0015] Preferably, the mixed solvent in step (1) is a mixture of formic acid and acetic acid.

[0016] More preferably, the mass ratio of the formic acid to the acetic acid is 70:30-50:50.

[0017] Preferably, the voltage for electrospinning in step (3) is 15-25 kV, and the flow rate of the injection pump in the syringe is 0.5-1.0 mL / h.

[0018] Preferably, the distance between the electrospinning head and the collecting plate in step (3) is 12-15 cm.

[0019] Preferably, the ambient temperature for electrospinning in step (3) is 22°C-26°C and the humidity is 40%-60%.

[0020] Preferably, the specific steps of vacuum drying in step (4) are as follows: vacuum drying at 30-80°C for 10-20 hours.

[0021] An application of a hydrating transparent medical dressing for wound healing, burn care, ulcer treatment, and postoperative wound care.

[0022] The present invention has the following advantages and beneficial effects compared with the prior art:

[0023] (1) The present invention uses ethyl laurate (EL) and polyamide 6 (PA6) to blend. The addition of ethyl laurate can provide a moist environment, reduce pain, promote wound healing and effectively prevent infection. Medical nanofiber dressings are prepared by electrospinning technology to improve the breathability and antibacterial properties of the dressings.

[0024] (2) The medical dressing prepared in this application has good breathability, transparency, and antibacterial properties, and is suitable for dressing treatment of wounds such as trauma, burns, ulcers, and surgical incisions. Its transparency allows for direct observation of the wound surface, facilitating timely assessment of wound healing, determining the need for further treatment, and reducing the frequency of dressing changes. For ulcers such as diabetic foot ulcers and pressure ulcers, the transparent dressing effectively covers the wound, reduces external contamination, and keeps the wound moist, promoting new tissue growth and ulcer healing. During the healing process of surgical incisions, the hydrating transparent medical dressing provides necessary protection and ensures the wound is in a suitable moist environment, reducing the risk of postoperative complications. Attached Figure Description

[0025] Figure 1 This is a scanning electron microscope image of the transparent medical dressing material with hydration properties prepared in Example 1.

[0026] Figure 2 Mechanical property testing of the hydration-responsive transparent medical dressing prepared in Example 1.

[0027] Figure 3 The image shows the antibacterial activity of the transparent medical dressing with hydration prepared in Example 1 before and after the addition of silver ions.

[0028] Figure 4 Figure 1 shows the water retention rate of dressings with different amounts of ethyl laurate added. Detailed Implementation

[0029] The invention's objective will be further described in detail below with reference to the accompanying drawings and specific embodiments. The embodiments cannot be repeated one by one here, but the implementation of the invention is not limited to the following embodiments.

[0030] Example 1

[0031] This embodiment discloses a method for preparing a transparent medical dressing with hydration properties;

[0032] (1) Preparation of PA6 solution: Weigh 50mg PA6 and dissolve it in a formic acid / acetic acid mixed solvent with a volume ratio of 70:30. Stir for 6 hours until a uniform and transparent solution is formed.

[0033] (2) Add 5 wt% ethyl laurate and stir continuously for 2 hours to ensure uniform dispersion;

[0034] (3) The prepared spinning solution is loaded into a syringe and spun through a high voltage electric field. The parameters of the electrospinning process are set as follows: voltage: 15 kV, injection pump flow rate: 0.5 mL / h, distance between spinning head and collection plate: 15 cm, ambient temperature: 25°C, humidity: 40%. Nanofibers are deposited on the collection plate to form a nanofiber nonwoven film.

[0035] (4) The obtained nanofiber nonwoven membrane was vacuum dried at 50°C for 12 hours to remove residual solvent and prepare a transparent medical dressing.

[0036] After soaking the material obtained above in a 30-40 ppm silver ion solution, apply the silver ion-soaked dressing to the second-degree burn wound and fix it with 3-M tape. Change the dressing after 3-5 days depending on the wound healing.

[0037] Example 2

[0038] The difference between this embodiment and Embodiment 1 is that 0 wt% ethyl laurate is added.

[0039] Example 3

[0040] The difference between this embodiment and Example 1 is that 10 wt% ethyl laurate is added.

[0041] Example 4

[0042] The difference between this embodiment and Example 1 is that 15 wt% ethyl laurate is added.

[0043] Figure 1 This is a scanning electron microscope image of the transparent medical dressing material with hydration properties prepared in Example 1. Figure 1 It is known that transparent medical dressings with hydration properties have multiple pores of 10-100um, which are fully breathable.

[0044] Figure 2 The mechanical property test diagram shows the transparent medical dressing with hydration prepared in Example 1. Figure 2 It is known that transparent medical dressings with hydration properties have a certain strain range, and the stress continues to rise as the strain increases. When applied to wounds (such as skin folds and active areas), they can stretch to a certain extent with the deformation of the skin, and are not easily broken or ineffective due to slight pulling. They have good conformability, can maintain contact with the wound during the application process, which is conducive to their function. They can withstand stress within a large strain range and have excellent ductility and toughness.

[0045] Figure 3 The graphs show the antibacterial activity of the transparent medical dressing with hydration prepared in Example 1 before and after the addition of silver ions. graph a shows the antibacterial activity before the use of silver ions, and graph b shows the antibacterial activity after the use of silver ions. Figure 3 It is known that after the dressing is soaked in silver ions, its ability to resist Staphylococcus aureus is enhanced, and it has good antibacterial properties, which can be better applied to clinical infected wounds.

[0046] Figure 4 To illustrate the water retention rate test results of dressings with different amounts of ethyl laurate, [the following is a separate, unrelated sentence:] , by Figure 4 It is known that ethyl laurate forms a hydrophobic film on the surface of the material, which can reduce the adhesion between the dressing and the wound, and at the same time, it can reduce the loss of moisture from the wound to a certain extent, creating a stable environment for wound healing.

[0047] The above-described specific embodiments are preferred embodiments of the present invention and are not intended to limit the present invention. Any other changes or equivalent substitutions made without departing from the technical solution of the present invention are included within the protection scope of the present invention.

Claims

1. A transparent medical dressing with water activity, characterized in that, It includes polyamide 6 and ethyl laurate, wherein the mass ratio of polyamide 6 to ethyl laurate is 1~3:

20.

2. Process for the production of a transparent medical dressing with water-binding properties according to claim 1, characterized in that, The specific steps are as follows: (1) Weigh out polyamide 6 and dissolve it in the mixed solvent, stir for 6-8 hours until a uniform and transparent solution is formed; (2) Add ethyl laurate and stir continuously to ensure uniform dispersion to obtain the spinning solution; (3) The spinning solution is loaded into a syringe and electrospinned by a high voltage electric field. The nanofibers are deposited on the collecting plate to form a nanofiber nonwoven film. (4) The obtained nanofiber nonwoven membrane is vacuum dried to obtain a transparent medical dressing with hydration function.

3. The method of producing a transparent medical dressing with hydration according to claim 2, characterized in that, The mixed solvent in step (1) is a mixture of formic acid and acetic acid.

4. The method of producing a transparent medical dressing with hydration according to claim 3, characterized in that, The mass ratio of formic acid to acetic acid is 70:30-50:

50.

5. The method for preparing a transparent medical dressing with hydration effect according to claim 2, characterized in that, In step (3), the voltage for electrospinning is 15-25 kV, and the flow rate of the injection pump in the syringe is 0.5-1.0 mL / h.

6. The method of making a transparent medical dressing with hydration according to claim 2, wherein, In step (3), the distance between the spinning head of the electrospinning process and the collecting plate is 12-15 cm.

7. The method of making a transparent medical dressing with hydration according to claim 2, wherein, In step (3), the ambient temperature for electrospinning is 22°C-26°C and the humidity is 40%-60%.

8. The method of making a transparent medical dressing with hydration according to claim 2, wherein, The specific steps of vacuum drying in step (4) are as follows: vacuum drying at 30-80°C for 10-20 hours.

9. Use of the transparent medical dressing with water-binding properties according to claim 1, characterized in that, It is used in wound healing, burn care, ulcer treatment, and postoperative wound care.

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