A biological membrane dressing and its use in the treatment of multiple types of wounds

Abstract

The application discloses a kind of biological membrane dressings and its application in the treatment of multiple types of injuries, the dressing with egg white, fibrinolysin, soybean small molecule peptide as main film-forming matrix, can be selectively added to one or more active ingredients of Chinese herbal medicine, such as radix cirsii japonici, bletilla striata, portulaca oleracea, radix pteroxygoni, sophora flavescens, panax notoginseng, menthol powder, according to different wound types, can be made into ready-to-use gel or freeze-dried powder.The biological membrane dressing provided by the application can quickly form a dense protective film on the wound surface, physically seal the wound, effectively prevent fluid loss and bacterial infection, so as to skip the shock period and inflammation period.The dressing has the effects of rapid analgesia, detumescence, scabbing and promoting healing, and can significantly inhibit scar formation, and is suitable for the treatment of burns and scalds, surgical incisions, abrasions, chronic ulcers, diabetic foot, urticaria, herpes zoster, frostbite, penetrating wounds, lacerations, sprains, strains, contusions, arthritis, bone repair, animal bites, fungal infections and skin inflammation and the treatment of various injuries.

Description

Technical Field

[0001] This invention relates to the field of biomedical technology, specifically to a biofilm dressing and its application in the treatment of various types of injuries and diseases. It is particularly suitable for the rapid, scarless repair of new and old burns, knife (surgical) wounds, abrasions, ulcerated wounds (including diabetic foot), urticaria, herpes zoster, chilblains, frostbite, unidentified swellings, penetrating wounds, lacerations, animal bites, scar repair, fungal infections, skin inflammation, acute sprains, fracture healing, etc., as well as for the external treatment of internal diseases. Background Technology

[0002] In the field of clinical surgical trauma treatment, existing treatment methods still face a series of serious challenges. For common traumas such as burns and diabetic foot, the treatment process is often complex and the efficacy is limited. Conventional therapies generally cannot overcome the long inflammatory phase, requiring large amounts of intravenous fluids to maintain vital signs, antibiotics to control infection, and frequent debridement and dressing changes. This not only leads to a long treatment course, often lasting for several months, but also easily induces complications such as shock and secondary infections. According to statistics, the in-hospital mortality rate for patients with deep second-degree burns and above is still as high as 6%-20% (the results vary depending on the source of the data), and the treatment risks can never be ignored. In addition, for many internal organ diseases, oral administration methods result in low blood drug concentrations at the affected area, or surgical treatments are highly invasive and have poor efficacy.

[0003] Meanwhile, exorbitant medical costs pose another heavy burden. For example, the average treatment cost (including skin grafting) for third-degree burns is as high as 200,000 to 500,000 yuan; the annual treatment cost for chronic diabetic wounds is also between 50,000 and 100,000 yuan, placing a huge pressure on patients' families. In my country, there are over 10 million burn patients annually, of whom about 10% require hospitalization. If a highly efficient and cost-effective treatment technology could be promoted clinically, it would save patients' families a huge amount of money.

[0004] Furthermore, the issue of post-treatment sequelae is also prominent. Current technologies struggle to effectively inhibit scar tissue formation, and some patients may suffer from sequelae such as postherpetic neuralgia, with some even requiring amputation, severely impacting their quality of life and mental health. Simultaneously, the repeated debridement and dressing changes can cause secondary and multiple injuries to the wound due to mechanical tearing, thus delaying the healing process and worsening the condition.

[0005] The application scenarios of existing therapies are also significantly limited. They are highly dependent on medical equipment, sterile environments, and professional operation, making them difficult to adapt to the needs of special occasions such as home emergencies, battlefield first aid, and disaster relief. Currently, the incidence of various types of trauma is increasing year by year, and patients' requirements for the timeliness, safety, effectiveness, and cosmetic recovery of treatment technologies are also rising.

[0006] When faced with deep burns, large-area wounds, old injuries, and other complex traumas, conventional methods commonly used by medical institutions, such as shock prevention intravenous infusions, antibiotic treatment, silver sulfadiazine dressings, and moist therapy, while effective to some extent, cannot simultaneously achieve the biological functions of astringency, natural pressure application, anti-inflammation, sterilization, blood cooling, hemostasis, analgesia, thrombolysis, and blood circulation promotion. Therefore, they cannot achieve the goal of rapidly repairing local symptoms. While traditional Chinese medicine's external treatment techniques for internal diseases have some effect, their complexity, high skill requirements for operators, and limited penetration techniques and sustained therapeutic effects leave room for improvement. Therefore, developing an external treatment product that is broadly applicable, effective, easy to operate, and cost-effective has become an urgent need in both clinical practice and the market. Summary of the Invention

[0007] To address the shortcomings of existing technologies, this invention provides a biofilm dressing and its application in the treatment of various types of injuries and diseases. Utilizing film-forming technology with egg white, soybean small molecule peptides, and QK fibrinolytic enzyme, and adding different traditional Chinese medicines according to different injury types, a biofilm dressing is prepared. This dressing is repeatedly applied to the affected area, reapplied after drying, until a stable scab forms. This achieves rapid wound closure, prevents shock due to infiltration, and isolates the wound from air to prevent secondary infection. It achieves rapid pain relief, improves microcirculation, reduces swelling, promotes scab formation, rapidly repairs wounds, and prevents scar tissue formation. For diseases of internal organs, cupping and the permeation-promoting effect of borneol can similarly achieve the effects of improving microcirculation, cooling the blood and stopping bleeding, reducing inflammation and pain, and nourishing tissues and organs, thereby rapidly improving local symptoms and influencing the systemic neuroimmune regulatory mechanism.

[0008] The technical solution provided by this invention is as follows: This invention provides a biofilm dressing comprising the following raw materials in weight percentages: 20-100% egg white, 0-5% fibrinolytic enzyme, 0-5% soybean small molecule peptides, 0-10% Bletilla striata powder, 0-1.5% carboxymethyl cellulose and one of the following traditional Chinese medicines; Traditional Chinese Medicine I: 0-3% Polygonum multiflorum juice, 0-3% Sophora flavescens juice, 0-2% Borneol powder; Traditional Chinese Medicine II: 0-1% Cirsium japonicum juice, 0-1% Polygonum aviculare juice, 0-2% Portulaca oleracea, 0-2% Borneol powder; Traditional Chinese Medicine III: 0-1% thistle juice, 0-2% purslane, 0-2% borneol powder; Traditional Chinese Medicine IV: 1-3% Panax notoginseng powder, 1-2% Carthamus tinctorius, 0-2% Borneol powder; Traditional Chinese medicine V: 0-3% Sophora flavescens juice, 0-3% Phellodendron chinense juice, 0-2% Borneol powder; Traditional Chinese Medicine VI: 0-30% Paulownia root, 0-30% Rose leaf, 0-30% Gardenia root, 0-30% Crab, 0-2% Borneol powder; Traditional Chinese medicine VII: 0-2% thistle juice, 0-40% honey, or 0-40% aloe vera gel; Traditional Chinese medicine VIII: 10-40% radish peel, 10-40% rose flowers and leaves, 0-2% borneol powder; Traditional Chinese medicine IX: 0-3% Cirsium japonicum juice, 0-3% Polygonum aviculare juice, 0-3% Sophora flavescens juice.

[0009] Chinese herbal medicine X: 0-10% curcumin, 0-10% dragon's blood, 0-10% astragalus, 0-2% thistle juice, 0-2% purslane, 0-2% borneol powder.

[0010] Furthermore, a biofilm dressing comprises the following raw materials in weight percentages: 20-100% egg white, 0-5% fibrinolytic enzyme, 0-5% soybean small molecule peptides, 0-3% thistle juice, 0-3% angelica juice, 0-3% sophora root juice, 0-10% bletilla powder, 0-1.5% carboxymethyl cellulose, 0-2% borneol powder.

[0011] Furthermore, a biofilm dressing comprises the following raw materials in weight percentages: 20-100% egg white, 0-5% fibrinolytic enzyme, 0-5% soybean small molecule peptides, 0-3% thistle juice, 0-3% angelica juice, 0-3% sophora root juice, 0-40% honey or 0-40% aloe vera gel, 0-10% bletilla striata powder, 0-1.5% carboxymethyl cellulose.

[0012] Furthermore, a biofilm dressing comprises the following raw materials in weight percentages: 20-100% egg white, 0-5% fibrinolytic enzyme, 0-5% soybean small molecule peptides, 0-3% Angelica sinensis juice, 0-3% Sophora flavescens juice, 0-1% borneol powder.

[0013] Furthermore, a biofilm dressing comprises the following raw materials in weight percentages: 20-100% egg white, 0-5% fibrinolytic enzyme, 0-5% soybean small molecule peptides, 0-1% thistle juice, 0-2% purslane, 0-2% borneol powder.

[0014] Furthermore, a biofilm dressing comprises the following raw materials in weight percentages: 20-100% egg white, 0-5% fibrinolytic enzyme, 0-5% soybean small molecule peptides, 0-1% thistle juice, 0-2% purslane, 0-1% angelica juice, 0-2% borneol powder.

[0015] Furthermore, a biofilm dressing comprises the following raw materials in weight percentages: 20-100% egg white, 0-5% fibrinolytic enzyme, 0-5% soybean small molecule peptides, 0-3% thistle juice, 0-4% angelica juice, 0-4% sophora root juice, 0-1% borneol powder.

[0016] Furthermore, a biofilm dressing comprises the following raw materials in weight percentages: 20-100% egg white, 0-5% soybean small molecule peptides, 0-3% thistle juice, 0-3% angelica juice, 0-2% sophora root juice, 0-10% bletilla rhizome, 0-60% honey or 0-60% aloe vera gel.

[0017] Furthermore, a biofilm dressing comprises the following raw materials in weight percentages: 20-100% egg white, 0-5% soybean small molecule peptides, 0-3% thistle juice, 0-3% angelica juice, 0-2% sophora root juice, 0-30% honey, 0-30% aloe vera gel.

[0018] Based on the same inventive concept, the present invention provides a method for preparing a biofilm dressing as described above, comprising the following steps: S1. Preparation of Chinese herbal medicines: Fresh Chinese herbal medicine raw materials are processed; or the Chinese herbal medicines are further processed into freeze-dried powder; S2. Processing egg whites: Take fresh eggs, sterilize the eggshells, and then extract the egg whites. Sterilize the egg whites; or further process the egg whites into freeze-dried powder. S3. Mixing: Mix the Chinese herbal medicine obtained in step S1, the egg white obtained in step S2, and the soybean small molecule peptides in a certain proportion to prepare a biofilm dressing.

[0019] Furthermore, it also includes step S4: preparing the biofilm dressing obtained in step S3 into a lyophilized powder, which is then mixed with purified water to form a gel before use. Furthermore, in step S1, the processing of the Chinese herbal medicine raw materials involves juicing the Chinese herbal medicine and then centrifuging or pulverizing it into fine powder; in step S2, pasteurization is used to sterilize the egg white.

[0020] Based on the same inventive concept, the present invention provides a biofilm dressing as described in any of the above claims. Application in the preparation of drugs or medical dressings for the treatment of skin or subcutaneous tissue injuries; Alternatively, its use in the preparation of drugs or medical dressings for inhibiting scar hyperplasia; Or, its application in the preparation of skin repair cosmetic products; Or, its use in the treatment of sprains, contusions, strains and arthritis; Or, its application in the treatment of fracture healing; Or, its application in traditional Chinese medicine's treatment of internal diseases externally, external diseases externally, and simultaneous internal and external treatment.

[0021] Furthermore, the skin or subcutaneous tissue trauma includes burns, surgical incisions, abrasions, chronic skin ulcers, diabetic foot, urticaria lesions, herpes zoster lesions, frostbite, penetrating injuries, lacerations, animal bites, fungal infections, and other lesions of internal organs.

[0022] Furthermore, when the biofilm dressing is used to inhibit scar hyperplasia, a biofilm dressing containing carboxymethyl cellulose or Bletilla striata powder is used.

[0023] Furthermore, when the biofilm dressing is used in skin repair cosmetic products, a biofilm dressing containing honey or aloe vera juice is used.

[0024] Furthermore, the application method involves applying the biofilm dressing to the wound surface after cleaning and disinfection, allowing it to dry and form a film, and then repeatedly applying it until a stable protective scab is formed on the wound surface.

[0025] The beneficial effects of this invention are: This invention uses egg white, fibrinolytic enzyme, soybean small molecule peptides, Bletilla striata powder, and sodium carboxymethyl cellulose as basic components, and adds different Chinese herbal medicines and excipients according to different types of injuries and diseases to make a biofilm dressing. This biofilm dressing uses the film-forming properties of egg white, fibrinolytic enzyme, and soybean small molecule peptides to form a physical structure on the body surface that has the functions of isolation barrier, active astringency and pressure, and can controllably release the bioactive factors therein. It can form a dense biofilm on the wound (or sensitive points / areas of the body), quickly sealing the wound, effectively preventing fluid loss and bacterial invasion, enhancing the effectiveness of external drug administration, thus physically skipping the shock and inflammation phases, and greatly shortening the healing time. For first or second-degree burns, pain relief and initial scab formation can usually be achieved within 2 hours. Even for large-area burns or third or fourth-degree burns, after proper debridement, pain relief can be achieved within a few hours, and healing can be achieved in a few days to a week, shortening the treatment course by more than 80%. Moreover, the biofilm has a natural astringent and continuous pressure effect, which can automatically promote the extension of the skin at the wound edge towards the center of the wound, thereby reducing the wound area. At the same time, this physical barrier can inhibit the disordered proliferation of fibroblasts and granulation tissue and promote the orderly regeneration of the epidermis, thus significantly reducing scar formation and avoiding or reducing the need for skin grafts. Ultimately, it can improve local symptoms and have a synergistic regulatory effect on the neuroimmune microenvironment.

[0026] The biofilm dressing prepared by this invention is non-irritating to the skin and adopts an open treatment method of "no bandaging, no dressing change" for open wounds. It only needs to be repeatedly applied to the existing membrane, which greatly reduces the irritation to the wound, avoids multiple damage to the wound, and avoids the risk of infection and aggravation of the injury caused by repeated tearing of the wound.

[0027] This invention, through the flexible combination of different Chinese herbal medicines, has good effects on burns, scalds, surgical wounds, abrasions, scratches, ulcers, wounds of diabetic patients, urticaria, herpes zoster, unidentified swellings, fungal infections, frostbite, sprains, fractures, penetrating wounds, lacerations, bite wounds, and scar repair. It can minimize the occurrence of scar tissue for facial wounds and cesarean sections in pregnant women. It can also be developed into cosmetic products and to assist in scar repair. By incorporating different Chinese herbal ingredients and using physical penetration-enhancing methods such as cupping, ultrasound, and chemical penetration-enhancing methods such as borneol, Bletilla striata, and azone, it can be applied to the external treatment of internal diseases in traditional Chinese medicine.

[0028] The main components of the biofilm dressing of this invention are egg white, fibrinolytic enzyme, soybean small molecule peptides, Bletilla striata powder, and sodium carboxymethyl cellulose. These components are widely available, inexpensive, and have low treatment costs. Furthermore, the dressing is simple to use and requires no complex equipment, significantly reducing treatment expenses. Egg white and soybean small molecule peptides directly provide protein for wound repair. Fibrinolytic enzyme, through its permeation-enhancing technology, can dissolve microthrombi formed at the affected area. Bletilla striata powder possesses unique bioactivity and strengthens the membrane. Sodium carboxymethyl cellulose enhances film-forming properties. The traditional Chinese medicine ingredients have cooling, hemostatic, anti-inflammatory, blood-activating, stasis-removing, and antibacterial effects, targeting different types of injuries, thus accelerating local symptom repair and providing good therapeutic effects for various types of injuries. Attached Figure Description

[0029] Figure 1 This is a comparison chart showing the effects of the biofilm dressing prepared in Example 2 of this invention before and after treatment in Case 1.

[0030] Figure 2 This is a comparison of the effects of the biofilm dressing prepared in Example 2 of this invention before and after treatment in Case 2.

[0031] Figure 3 The image shows a comparison of the effects of the biofilm dressing prepared in Example 2 of this invention before and after treatment in Case 3.

[0032] Figure 4 This is a comparison of the effects of the biofilm dressing prepared in Example 1 of this invention before and after treatment in Case 4.

[0033] Figure 5 This is a comparison of the effects of the biofilm dressing prepared in Example 2 of this invention before and after treatment in Case 5.

[0034] Figure 6 This is a comparison of the effects of the biofilm dressing prepared in Example 13 of this invention before and after treatment in Case 8.

[0035] Figure 7 The image shows a comparison of the effects of the biofilm dressing prepared in Example 2 of this invention before and after treatment in Case 10.

[0036] Figure 8The image shows a comparison of the effects of the biofilm dressing prepared in Example 2 of this invention before and after treatment in Case 11.

[0037] Figure 9 The image shows a comparison of the effects of the biofilm dressing prepared in Example 1 of this invention before and after treatment in Case 12. Detailed Implementation

[0038] The features mentioned above, or the features mentioned in the embodiments, of this invention can be combined arbitrarily. All features explained in this specification can be used with any methodological form, and each feature disclosed in the specification can be replaced by any alternative feature that provides the same, equivalent, or similar purpose. Therefore, unless otherwise specified, the disclosed features are merely general examples of equivalent or similar features.

[0039] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions of this invention will be clearly and completely described below in conjunction with the embodiments of this invention. Obviously, the described embodiments are only some embodiments of this invention, not all embodiments. Based on the embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this invention. It should be noted that, unless otherwise specified, all chemical reagents involved in this invention are purchased through commercial channels.

[0040] The present invention will be further illustrated below with reference to specific embodiments. These embodiments are for illustrative purposes only and are not intended to limit the scope of the invention. Example

[0041] This embodiment provides a biofilm dressing comprising the following raw materials by weight percentage: 86% egg white, 2% fibrinolytic enzyme, 5% soybean small molecule peptides, 1% Angelica sinensis juice, 5% Bletilla striata powder, 1% borneol powder; This embodiment provides a method for preparing a biofilm dressing, including the following steps: S1. Preparation of Chinese herbal medicine: Take fresh Polygonum cuspidatum, extract the juice and centrifuge to obtain the clear liquid of Chinese herbal medicine. Take fresh Bletilla striata, crush it, and mix the clear liquid of Chinese herbal medicine, Bletilla striata powder and borneol powder evenly to obtain Chinese herbal medicine. Preferably, the traditional Chinese medicine can be further processed into freeze-dried powder for easy storage and transportation; S2. Processing egg whites: Take fresh eggs, disinfect the egg surface with 75% alcohol, then remove the egg whites and sterilize them using pasteurization. S3. Mixing: Mix the Chinese herbal medicine obtained in step S1, the egg white obtained in step S2, the soybean small molecule peptides, and the fibrinolytic enzyme in a certain proportion to prepare a biofilm dressing.

[0042] The biofilm dressing provided in this embodiment can be used for newly occurring burns, scalds, abrasions, cuts, bite wounds, penetrating wounds, and lacerations. The specific method of use is as follows: First, rinse the wound with cool water for 1-30 minutes to lower the wound temperature and avoid deep burns. For burns of second degree or less, no disinfection is required. Apply the biofilm dressing described in this example directly. After the dressing dries, continue applying until the pain subsides. Generally, pain relief can be achieved within 2 hours. Afterward, apply the dressing every 4 hours until a scab forms. Once the scab forms, apply the dressing as needed depending on the integrity of the dressing. If there is no inflammatory reaction (i.e., redness, swelling, or fluctuation) in the dermis after the scab hardens, simply protect the scab and allow it to fall off naturally. Do not allow it to fall off due to external force, otherwise, the scar may enlarge or the biofilm dressing may need to be reapplied. Mild burns generally heal within 2 hours, while relatively severe burns take 3-6 hours to stop pain and form a scab. For large-area burns, the treatment method is the same, but the pain relief time will be extended to 3-8 hours. The subsequent treatment method is the same as before. For newly developed third- or fourth-degree burns, after rinsing with cold water, thorough debridement is necessary, mainly to remove dust, impurities, and other foreign objects. Then disinfect with povidone-iodine or iodine tincture, rinse with saline solution, and apply this biofilm dressing. Reapply after it dries until a scab forms. This process takes 2-8 hours. Post-scab treatment is the same as before. However, if redness, swelling, or fluctuation occurs after scab formation, it indicates a bacterial infection, requiring antibiotics. Soak the scab in saline solution to remove it, clean away pus and debris, disinfect again, and then apply the biofilm dressing again. It will quickly scab over and enter the repair phase. Note that contact with tap water is prohibited during treatment. Protect the scab to allow it to fall off naturally. For abrasions, scratches, cuts, bite wounds, penetrating wounds, and lacerations, thorough debridement and disinfection are required before applying the dressing. Reapply after it dries until a scab forms. Subsequent treatment is the same as for other types of wounds.

[0043] The biofilm dressing provided in this embodiment can also be used for shingles and urticaria. The specific method of use is as follows: After disinfecting with povidone-iodine, repeatedly apply the biofilm dressing of this embodiment, reapplying it as it dries, until recovery is achieved; it is important to protect the scab during the treatment process. Example

[0044] This embodiment provides a biofilm dressing comprising the following raw materials by weight percentage: 94% egg white, 5% soybean small molecule peptides, 1% thistle juice.

[0045] This embodiment provides a method for preparing a biofilm dressing, including the following steps: S1. Preparation of Chinese herbal medicine: Take fresh thistle, extract its juice and centrifuge to obtain a clear liquid of Chinese herbal medicine juice; Preferably, the herbal juice can be further processed into freeze-dried powder for easy storage and transportation; S2. Processing egg whites: Take fresh eggs, disinfect the egg surface with 75% alcohol, then remove the egg whites and sterilize them using pasteurization. Preferably, the egg whites can be further processed into freeze-dried powder for easy storage and transportation; S3. Mixing: Mix the Chinese herbal medicine obtained in step S1, the egg white obtained in step S2, and the soybean small molecule peptides in a certain proportion to prepare a biofilm dressing.

[0046] The biofilm dressing provided in this embodiment can be used for chronic non-healing wounds caused by old burns or other skin injuries. The specific method of use is as follows: If there is no inflammation, first thoroughly clean the wound with hydrogen peroxide or saline solution, disinfect with iodine, rinse with saline solution, and then apply the biofilm dressing of this embodiment until a scab forms. After the scab forms, apply the dressing as needed depending on the integrity of the membrane. If there is no inflammatory reaction (i.e., redness or fluctuation) in the dermis inside the scab after it hardens, simply protect the scab and let it fall off naturally without external force. Otherwise, the biofilm dressing needs to be reapplied. If there is inflammation or redness, antibiotics are needed to reduce the inflammation, and the scab should be soaked and washed away with saline solution. Clean the pus or debris again, disinfect, and then apply the biofilm dressing again. It should be noted that contact with tap water is prohibited during the treatment process.

[0047] The biofilm dressing provided in this embodiment is for chilblains. The specific method of use is as follows: For chilblains, which can be treated as other types of injuries, if there is no inflammation, first thoroughly clean the wound with hydrogen peroxide or saline solution, disinfect with iodine, rinse with saline solution, and then apply the biofilm dressing of this embodiment until a scab forms. After the scab forms, apply the dressing as needed depending on the integrity of the membrane. If there is no inflammatory reaction (i.e., redness or fluctuation) in the dermis inside the scab after it hardens, simply protect the scab and let it fall off naturally, preventing it from falling off due to external force. Otherwise, the biofilm dressing needs to be reapplied. If there is inflammation or redness and swelling, antibiotics are needed to reduce inflammation, and the scab needs to be soaked and washed away with saline solution. Clean the pus or debris again, disinfect, and then apply the biofilm dressing again. It should be noted that contact with tap water is prohibited during the treatment process.

[0048] The biofilm dressing provided in this embodiment can also be used on surgical wounds. The specific method of use is as follows: After disinfecting the wound with povidone-iodine, rinse off the povidone-iodine with saline solution. Then apply the biofilm dressing of this embodiment until a scab forms. After the scab forms, apply the dressing as needed depending on the integrity of the membrane. If there is no inflammatory reaction (i.e., redness or fluctuation) in the dermis inside the scab after it hardens, simply protect the scab and let it fall off naturally without external force. Otherwise, the biofilm dressing needs to be reapplied. If there is inflammation or redness, antibiotics should be used to reduce inflammation, and the scab should be soaked and washed off with saline solution. After disinfection, the biofilm dressing should be reapplied. It should be noted that contact with tap water is prohibited during the treatment process.

[0049] The biofilm dressing provided in this embodiment can also be used for diabetic foot. The specific method of use is as follows: After thorough cleaning and disinfection, apply the biofilm dressing of this embodiment until a scab forms. Pay close attention to the condition inside the scab. If infection is found, antibiotics should be used to reduce inflammation, and the wound should be thoroughly cleaned and disinfected immediately before applying the biofilm dressing. Note that contact with tap water is prohibited during treatment. Example

[0050] This embodiment provides a biofilm dressing comprising the following raw materials by weight percentage: 87% egg white, 2% fibrinolytic enzyme, 5% soybean small molecule peptides, 2% Panax notoginseng powder, 2% safflower, 2% borneol powder.

[0051] This embodiment provides a method for preparing a biofilm dressing, including the following steps: S1. Preparation of Chinese herbal medicine: Take fresh Panax notoginseng, crush it and sieve it to obtain Panax notoginseng powder. Safflower can be left unprocessed. Mix Panax notoginseng powder and safflower evenly. S2. Processing egg whites: Take fresh eggs, disinfect the egg surface with 75% alcohol, then remove the egg whites and sterilize them using pasteurization. S3. Mixing: Mix the Chinese herbal medicine obtained in step S1, the egg white obtained in step S2, and soybean small molecule peptides, fibrinolytic enzymes, and borneol powder in a certain proportion to prepare a biofilm dressing.

[0052] The biofilm dressing provided in this embodiment can be used for frostbite. The specific method of use is as follows: For frostbite, the biofilm dressing prepared in this embodiment should be applied externally, and KQ fibrinolytic enzyme natto red yeast rice capsules, Panax notoginseng or Jin Gu Tong and other traditional Chinese medicines that promote blood circulation and remove blood stasis should also be taken orally. It should be noted that the temperature should not be raised rapidly during the treatment. Example

[0053] This embodiment provides a biofilm dressing comprising the following raw materials by weight percentage: 20% egg white, 2% fibrinolytic enzyme, 5% soybean small molecule peptides, 46% radish peel, 15% rose petals, 10% rose leaves, 2% borneol powder.

[0054] This embodiment provides a method for preparing a biofilm dressing, including the following steps: S1. Preparation of Chinese herbal medicine: Take fresh radish peel, rose flowers, and rose leaves, and crush them; S2. Processing egg whites: Take fresh eggs, disinfect the egg surface with 75% alcohol, then remove the egg whites and sterilize them using pasteurization. S3. Mixing: Mix the Chinese herbal medicine obtained in step S1, the egg white obtained in step S2, and soybean small molecule peptides, fibrinolytic enzymes, and borneol powder in a certain proportion to prepare a biofilm dressing.

[0055] The biofilm dressing provided in this embodiment can be used for sprains, contusions, strains, and arthritis. The specific method of use is as follows: apply the biofilm dressing of this embodiment to the affected area and bandage it with gauze, and change the dressing once a day. Example

[0056] This embodiment provides a biofilm dressing comprising the following raw materials by weight percentage: 91% egg white, 5% soybean small molecule peptides, 2% Sophora flavescens juice, 2% Phellodendron amurense juice.

[0057] This embodiment provides a method for preparing a biofilm dressing, including the following steps: S1. Preparation of Chinese herbal medicine: Take fresh Sophora flavescens and Phellodendron chinense, mix them and juice them, then centrifuge to obtain a clear liquid of Chinese herbal medicine juice; Preferably, the herbal juice can be further processed into freeze-dried powder for easy storage and transportation; S2. Processing egg whites: Take fresh eggs, disinfect the egg surface with 75% alcohol, then remove the egg whites and sterilize them using pasteurization. S3. Mixing: Mix the Chinese herbal medicine obtained in step S1, the egg white obtained in step S2, and the soybean small molecule peptides in a certain proportion to prepare a biofilm dressing.

[0058] The biofilm dressing provided in this embodiment can be used for fungal infections. The specific method of use is as follows: after cleaning and disinfecting the affected area, apply the biofilm dressing of this embodiment repeatedly until a stable scab is formed.

[0059] However, for onychomycosis (fungal nail infection), it is necessary to thoroughly remove the necrotic nail and apply the biofilm dressing of this embodiment repeatedly to form a hard scab; it should be noted that a layer of nail polish should be applied on the hard scab. Example

[0060] This embodiment provides a biofilm dressing comprising the following raw materials by weight percentage: 23% egg white, 5% soybean small molecule peptides, 20% paulownia root, 15% rose leaf, 20% gardenia root, 15% crab, 2% borneol powder.

[0061] This embodiment provides a method for preparing a biofilm dressing, including the following steps: S1. Preparation of Chinese herbal medicine: Take fresh paulownia root, rose leaf, gardenia root, and crab, and crush them. S2. Processing egg whites: Take fresh eggs, disinfect the egg surface with 75% alcohol, then remove the egg whites and sterilize them using pasteurization. S3. Mixing: Mix the Chinese herbal medicine obtained in step S1, the egg white obtained in step S2, the soybean small molecule peptides, and the borneol powder in a certain proportion to prepare a biofilm dressing.

[0062] The biofilm dressing provided in this embodiment is for fracture healing, and the specific method of use is as follows: The biofilm dressing of this embodiment is applied to the fracture site after reduction. It needs to be bandaged and the dressing changed every two days until recovery. Example

[0063] This embodiment provides a biofilm dressing comprising the following raw materials by weight percentage: 73% egg white, 5% soybean small molecule peptides, 2% thistle juice, 20% honey; Honey can be replaced with aloe vera gel.

[0064] This embodiment provides a method for preparing a biofilm dressing, including the following steps: S1. Preparation of Chinese herbal medicine: Take fresh thistle, extract its juice and centrifuge to obtain a clear liquid of Chinese herbal medicine juice; Preferably, the herbal juice can be further processed into freeze-dried powder for easy storage and transportation; S2. Processing egg whites: Take fresh eggs, disinfect the egg surface with 75% alcohol, then remove the egg whites and sterilize them using pasteurization. S3. Mixing: Mix the Chinese herbal medicine obtained in step S1, the egg white obtained in step S2, the soybean small molecule peptides, and the honey in a certain proportion to prepare a biofilm dressing.

[0065] The biofilm dressing provided in this embodiment is for cosmetic purposes, and the specific method of use is as follows: Apply the biofilm dressing of this embodiment to the face or hands every night, leave it on for half an hour, and then wash it off with water. Use it 2-3 times a week. Example

[0066] This embodiment provides a biofilm dressing comprising the following raw materials by weight percentage: 70% egg white, 5% soybean small molecule peptides, 2% thistle juice, 2% angelica juice, 1% sophora root juice, 20% honey; Honey can be replaced with aloe vera gel.

[0067] This embodiment provides a method for preparing a biofilm dressing, including the following steps: S1. Preparation of Chinese herbal medicine: Take fresh Cirsium japonicum, Angelica sinensis and Sophora flavescens, mix them and juice them, and centrifuge to obtain clear Chinese herbal medicine juice; Preferably, the herbal juice can be further processed into freeze-dried powder for easy storage and transportation; S2. Processing egg whites: Take fresh eggs, disinfect the egg surface with 75% alcohol, then remove the egg whites and sterilize them using pasteurization. S3. Mixing: Mix the Chinese herbal medicine obtained in step S1, the egg white obtained in step S2, the soybean small molecule peptides, and honey (or aloe vera gel) in a certain proportion to prepare a biofilm dressing.

[0068] The biofilm dressing provided in this embodiment is for cosmetic purposes, and the specific method of use is as follows: Apply the biofilm dressing of this embodiment to the face or hands every night, leave it on for half an hour, and then wash it off with water. Use it 2-3 times a week. Example

[0069] This embodiment provides a biofilm dressing comprising the following raw materials by weight percentage: 90% egg white, 5% soybean small molecule peptides, 2% thistle juice, 2% angelica juice, 1% sophora root juice.

[0070] This embodiment provides a method for preparing a biofilm dressing, including the following steps: S1. Preparation of Chinese herbal medicine: Take fresh Cirsium japonicum, Angelica sinensis and Sophora flavescens, mix them and juice them, and centrifuge to obtain clear Chinese herbal medicine juice; Preferably, the herbal juice can be further processed into freeze-dried powder for easy storage and transportation; S2. Processing egg whites: Take fresh eggs, disinfect the egg surface with 75% alcohol, then remove the egg whites and sterilize them using pasteurization. S3. Mixing: Mix the Chinese herbal medicine obtained in step S1, the egg white obtained in step S2, and the soybean small molecule peptides in a certain proportion to prepare a biofilm dressing.

[0071] The biofilm dressing provided in this embodiment can be used for all the above-mentioned traumas, such as new and old burns, knife (surgical) wounds, abrasions, ulcers (including diabetic foot), urticaria, herpes zoster, chilblains, frostbite, unidentified swellings, penetrating wounds, lacerations, animal bites, fungal infections, and skin inflammation. It should be noted that for lesions of internal organs, cupping should be performed for 5-10 minutes before applying or dispensing the dressing to acupoints or projection areas to facilitate drug absorption and utilization. During the treatment, areas with skin lesions should not come into contact with untreated water. Example

[0072] This embodiment provides a biofilm dressing comprising the following raw materials by weight percentage: 87% egg white, 3% soybean small molecule peptides, 2% thistle juice, 2% angelica juice, 1% sophora root juice, 5% bletilla powder.

[0073] This embodiment provides a method for preparing a biofilm dressing, including the following steps: S1. Preparation of Chinese herbal medicine: Take fresh Cirsium japonicum, Angelica sinensis and Sophora flavescens, mix them and juice them, centrifuge to obtain clear Chinese herbal medicine juice, then prepare Bletilla striata into ultrafine powder, and mix the clear Chinese herbal medicine juice with Bletilla striata powder evenly. Preferably, the traditional Chinese medicine can be further processed into freeze-dried powder for easy storage and transportation; S2. Processing egg whites: Take fresh eggs, disinfect the egg surface with 75% alcohol, then remove the egg whites and sterilize them using pasteurization. S3. Mixing: Mix the Chinese herbal medicine obtained in step S1, the egg white obtained in step S2, and the soybean small molecule peptides in a certain proportion to prepare a biofilm dressing.

[0074] The biofilm dressing provided in this embodiment can be used to repair old scars. The specific method of use is as follows: simply apply the biofilm dressing of this embodiment to the old scars after surgery. It can significantly reduce the recurrence rate and greatly shorten the healing time. It should be noted that contact with tap water is prohibited during the treatment process. Example

[0075] This embodiment provides a biofilm dressing comprising the following raw materials by weight percentage: 88% egg white, 5% soybean small molecule peptides, 1% thistle juice, 1% angelica juice, 5% sophora root juice, 1% bletilla powder, 1% sodium carboxymethyl cellulose.

[0076] This embodiment provides a method for preparing a biofilm dressing, including the following steps: S1. Preparation of Chinese herbal medicine: Take fresh Cirsium japonicum, Angelica sinensis and Sophora flavescens, mix them and juice them. After centrifugation, obtain the clear liquid of Chinese herbal medicine. Then prepare Bletilla striata into ultrafine powder. Mix the clear liquid of Chinese herbal medicine with Bletilla striata powder evenly. Preferably, the traditional Chinese medicine can be further processed into freeze-dried powder for easy storage and transportation; S2. Processing egg whites: Take fresh eggs, disinfect the egg surface with 75% alcohol, then remove the egg whites and sterilize them using pasteurization. S3. Mixing: Mix the Chinese herbal medicine obtained in step S1, the egg white obtained in step S2, the soybean small molecule peptides and carboxymethyl cellulose in a certain proportion to prepare a biofilm dressing.

[0077] The biofilm dressing provided in this embodiment can be used for fungal infections, etc. The specific method of use is as follows: apply the biofilm dressing of this embodiment to the disinfected affected area, apply it again after it dries, and apply it repeatedly. It can come into contact with tap water. If it is onychomycosis (fungal nail infection), the nail needs to be soaked in hot water to soften it and the infected part needs to be scraped off with a knife before applying the dressing. After the hard film forms, cover it with nail polish. Example

[0078] This embodiment provides a biofilm dressing comprising the following raw materials by weight percentage: 89% egg white, 2% fibrinolytic enzyme, 5% soybean small molecule peptides, 3% angelica juice, 1% borneol powder.

[0079] This embodiment provides a method for preparing a biofilm dressing, including the following steps: S1. Preparation of Chinese herbal medicine: Take fresh Polygonum cuspidatum and Sophora flavescens, mix them and juice them, centrifuge to obtain the clear liquid of Chinese herbal medicine, then prepare Bletilla striata into ultrafine powder, and mix the clear liquid of Chinese herbal medicine, Bletilla striata powder and borneol powder evenly. Preferably, the traditional Chinese medicine can be further processed into freeze-dried powder for easy storage and transportation; S2. Processing egg whites: Take fresh eggs, disinfect the egg surface with 75% alcohol, then remove the egg whites and sterilize them using pasteurization. S3. Mixing: Mix the Chinese herbal medicine obtained in step S1, the egg white obtained in step S2, the soybean small molecule peptides, and QK fibrinolytic enzyme in a certain proportion to prepare a biofilm dressing.

[0080] The biofilm dressing provided in this embodiment can be used for viral infections such as herpes zoster. The specific method of use is as follows: apply the biofilm dressing of this embodiment to the disinfected affected area, apply it again after it dries, until the pain disappears and the herpes subsides. During this period, you can also take the decoction of Polygonum multiflorum and Angelica sinensis orally. By improving the local symptoms, it can affect the changes in the systemic neuroimmune regulation mechanism to regulate the body's health. Example

[0081] This embodiment provides a biofilm dressing comprising the following raw materials by weight percentage: 92% egg white, 5% soybean small molecule peptides, 1% thistle juice, 2% purslane.

[0082] This embodiment provides a method for preparing a biofilm dressing, including the following steps: S1. Preparation of Chinese herbal medicine: Take fresh thistle, extract its juice and centrifuge it to obtain thistle juice, then crush purslane and mix the thistle juice and purslane evenly. Preferably, the traditional Chinese medicine can be further processed into freeze-dried powder for easy storage and transportation; S2. Processing egg whites: Take fresh eggs, disinfect the egg surface with 75% alcohol, then remove the egg whites and sterilize them using pasteurization. S3. Mixing: Mix the Chinese herbal medicine obtained in step S1, the egg white obtained in step S2, and the soybean small molecule peptides in a certain proportion to prepare a biofilm dressing.

[0083] The biofilm dressing provided in this embodiment can be used for new and old burns, knife (surgical) wounds, abrasions, ulcers (including diabetic foot), urticaria, frostbite, penetrating wounds, lacerations, animal bites, and skin inflammation. The specific method of use is as follows: apply the biofilm dressing of this embodiment to the wound after cleaning and disinfection, apply repeatedly, and apply again after it dries, until a hard scab forms. After the hard scab forms, it can be applied only two to three times a day. Example

[0084] This embodiment provides a biofilm dressing comprising the following raw materials by weight percentage: 70% egg white, 5% soybean small molecule peptides, 1% thistle juice, 2% purslane, 5% fibrinolytic enzyme, 5% curcumin, 2% borneol powder, 5% dragon's blood, 5% astragalus. This embodiment provides a method for preparing a biofilm dressing, including the following steps: S1. Preparation of Chinese herbal medicine: Take fresh thistle and purslane, extract their juice and centrifuge to obtain the clear liquid. Extract the effective components (or pulverize) curcumin, dragon's blood and astragalus. Mix the clear liquid of Chinese herbal medicine with the powder evenly. Preferably, the traditional Chinese medicine can be further processed into freeze-dried powder for easy storage and transportation; S2. Processing egg whites: Take fresh eggs, disinfect the egg surface with 75% alcohol, then remove the egg whites and sterilize them using pasteurization. S3. Mixing: Mix the Chinese herbal medicine obtained in step S1, the egg white obtained in step S2, and soybean small molecule peptides, fibrinolytic enzymes, and borneol powder in a certain proportion to prepare a biofilm dressing.

[0085] The biofilm dressing provided in this embodiment can be used for lesions of internal organs, new and old burns, knife (surgical) wounds, abrasions, ulcers (including diabetic foot), urticaria, frostbite, unidentified swellings, penetrating wounds, lacerations, animal bites, and skin inflammation. The specific method of use is as follows: apply the biofilm dressing of this embodiment to the wound surface after cleaning and disinfection (or after cupping), apply repeatedly, and apply again after it dries, until a hard scab forms. After the hard scab forms, it can be applied only two to three times a day. Example

[0086] This embodiment provides a biofilm dressing comprising the following raw materials by weight percentage: 20% egg white, 5% soybean small molecule peptides, 40% radish peel, 33% rose flowers and leaves, 2% borneol powder.

[0087] This embodiment provides a method for preparing a biofilm dressing, including the following steps: S1. Preparation of Chinese herbal medicine: Take fresh radish peel and mash it, mash the flowers and leaves of rose, mix them together and then mix them evenly with borneol powder. Preferably, the traditional Chinese medicine can be further processed into freeze-dried powder for easy storage and transportation; S2. Processing egg whites: Take fresh eggs, disinfect the egg surface with 75% alcohol, then remove the egg whites and sterilize them using pasteurization. S3. Mixing: Mix the Chinese herbal medicine obtained in step S1, the egg white obtained in step S2, the soybean small molecule peptides, and the borneol powder in a certain proportion to prepare a biological dressing.

[0088] The biological dressing provided in this embodiment can be used for new and old sprains, strains, contusions, and arthritis. The specific method of use is as follows: apply the biological dressing of this embodiment to the injured area and bandage it with gauze. Change the dressing once a day. Example

[0089] This embodiment provides a biofilm dressing comprising the following raw materials by weight percentage: 27% egg white, 5% soybean small molecule peptides, 3% thistle juice, 5% Bletilla striata powder, 60% honey; Honey can be replaced with an equal amount of aloe vera gel, or a mixture of 30% honey and 30% aloe vera juice.

[0090] This embodiment provides a method for preparing a biofilm dressing, including the following steps: S1. Preparation of Chinese herbal medicine: Take fresh thistle and aloe vera, extract juice from them separately, centrifuge to obtain clear Chinese herbal medicine juice, then prepare Bletilla striata into ultrafine powder, and mix the clear Chinese herbal medicine juice with Bletilla striata powder evenly. Preferably, the traditional Chinese medicine can be further processed into freeze-dried powder for easy storage and transportation; S2. Processing egg whites: Take fresh eggs, disinfect the egg surface with 75% alcohol, then remove the egg whites and sterilize them using pasteurization. S3. Mixing: Mix the Chinese herbal medicine obtained in step S1, the egg white obtained in step S2, the soybean small molecule peptides, and honey (or aloe vera gel) in a certain proportion to prepare a biofilm dressing.

[0091] The biofilm dressing provided in this embodiment can be used for daily skin management. The specific method of use is as follows: apply the biofilm dressing of this embodiment to the face or hands for half an hour each time, and then wash it off with water, 2-3 times a week. Example

[0092] This embodiment provides a biofilm dressing comprising the following raw materials by weight percentage: 84% egg white, 2% fibrinolytic enzyme, 5% soybean small molecule peptides, 2% thistle juice, 5% angelica juice, 2% borneol powder.

[0093] This embodiment provides a method for preparing a biofilm dressing, including the following steps: S1. Preparation of Chinese herbal medicine: Take fresh Cirsium japonicum and Angelica sinensis, mix them evenly and then squeeze out the juice. After centrifugation, obtain the clear liquid of Chinese herbal medicine juice, and then mix it evenly with borneol powder to obtain Chinese herbal medicine. Preferably, the herbal juice can be further processed into freeze-dried powder for easy storage and transportation; S2. Processing egg whites: Take fresh eggs, disinfect the egg surface with 75% alcohol, then remove the egg whites and sterilize them using pasteurization. S3. Mixing: Mix the Chinese herbal medicine obtained in step S1, the egg white obtained in step S2, the soybean small molecule peptides, and the fibrinolytic enzyme in a certain proportion to prepare a biofilm dressing.

[0094] The biofilm dressing provided in this embodiment can be used as an adjunct treatment for snake venom and insect venom. The specific method of use is as follows: apply the biofilm dressing of this embodiment to the wound after it has been cleaned with alkaline water, and reapply it when it dries. For snake venom, it is best to go to the hospital in time to receive antivenom to ensure that nothing goes wrong.

[0095] Typical Case Case 1 (Old Deep Burns) The patient suffered chronic deep burns, classified as fourth-degree burns, due to moxibustion. They had been treated at various medical institutions and burn specialists for over seventy days. The wound contained pus, posing a risk of secondary infection. Treatment began on the evening of July 18, 2025, using the biofilm dressing prepared according to Example 2 of this invention. A scab formed three hours after application, and no infection occurred. Only six applications were required throughout the entire treatment.

[0096] After treatment, a scab will form naturally, awaiting the repair of new tissue. (See reference...) Figure 1 .

[0097] Case 2 (Old fourth-degree burns) The patient suffered low-temperature burns, classified as fourth-degree burns, due to exposure to electric heat. After nearly four months of treatment in the hospital, the burns had not healed. However, after using the biofilm dressing prepared in Example 2 of this invention, the burns formed a scab within a few hours, and the wounds were basically healed after ten days.

[0098] The wound healed well after treatment, and the treatment course was significantly shortened. (Refer to...) Figure 2 .

[0099] Case 3 (Old Burns) The patient, a catering worker, scalded his forearm with boiling water while pouring tea for a customer. Other treatments were ineffective after four days. On November 30, 2025, he began using the biofilm dressing prepared in Example 2 of this invention. The dressing scabbed over in three hours and he was basically healed after four days.

[0100] The wound healed well after treatment, leaving no scars. (See reference) Figure 3 .

[0101] Case 4 (Deep Second-Degree Burns) The patient suffered a deep second-degree burn to the head from the exhaust pipe of a wood-fired stove, with the epidermis detached. After rinsing with cold water for ten minutes, the biofilm dressing prepared in Example 1 of this invention was applied. Pain relief occurred within two hours, scab formation occurred within three hours, and new tissue grew back after twelve days without any scarring.

[0102] The wound healed rapidly after treatment, with no scar formation. (See reference) Figure 4 .

[0103] Case 5 (Third-degree burns) The patient suffered third-degree burns with deep wounds. The wounds were already in the inflammatory stage when treatment began. The first treatment failed due to incomplete debridement and sterilization, resulting in pseudo-healing and suppuration. After thorough debridement and disinfection with iodine, the biofilm dressing prepared in Example 2 of this invention was applied. The dressing formed a scab within a few hours and was basically healed after ten days.

[0104] The wound healed well after treatment, with only a small scar remaining due to insufficient protection of the scab. (See reference) Figure 5 .

[0105] Case 6 (New Burns) The patient, a diabetic, developed blisters 2 cm in diameter after burning his thigh. Instead of rinsing with cold water, the patient directly applied the biofilm dressing prepared in Example 2 of this invention. Pain relief occurred within 20 minutes, and the wound healed completely after seven days, leaving only a faint scar. The patient experienced no adverse reactions during medication use, and the wound healing speed far exceeded expectations. Typically, diabetic patients have longer wound healing periods and are more prone to infection, but in this case, the patient had a large burn area, the treatment process was simple, and the therapeutic effect was significant.

[0106] Case 7 (Motorcycle exhaust pipe burns) The patient overturned his motorcycle, burning his arm on the exhaust pipe. He immediately soaked the arm in cold water for 15 minutes and then applied the biofilm dressing prepared in Example 1 of this invention. The pain was relieved within two hours. After disinfection with iodine, the dressing was reused. Three days later, the necrotic skin fell off without any scarring.

[0107] The wound heals quickly and without scarring after treatment, which is superior to traditional treatment methods.

[0108] Case 8 (Penetrating Wound) The patient's finger was accidentally pierced by a No. 12 fishhook, 0.8 cm deep. At the hospital, the fishhook was removed with a scalpel. No stitches or tetanus shot were needed. Due to significant bleeding and the presence of penetrating, laceration, and surgical wounds, the biofilm dressing prepared in Example 4 of this invention was applied. It scabbed over within six hours, showed no inflammation, and healed completely within ten days without scarring. (Refer to...) Figure 6 .

[0109] Case 9 (New Burns) On April 2, 2024, the patient's foot was scalded by boiling water, causing significant pain. After using the biofilm dressing prepared in Example 1 of this invention, the symptoms were significantly relieved the next day, and the patient recovered after a few days.

[0110] Case 10 (Scalding of an old motorcycle exhaust pipe) On July 18, 2025, the patient suffered burns to his lower leg while riding a motorcycle. The burns persisted for a month. On August 23, 2025, after disinfection with iodine, the patient applied the biofilm dressing prepared in Example 2 of this invention. A scab formed within three hours, and the scab fell off and the patient recovered completely after seven days. (Refer to...) Figure 7 .

[0111] Case 11 (Urticaria) The patient experienced multiple episodes of urticaria in 2025, which were unresponsive to conventional treatments. After using the biofilm dressing prepared in Example 9 of this invention, the symptoms significantly subsided within one day, directly entering the repair phase. This improvement in local symptoms influenced changes in the systemic immune regulatory response. (Refer to...) Figure 8 .

[0112] Case Twelve (Biting) The patient, a 2-year-old boy, was bitten on the face by a dog on November 4, 2025. After wound cleaning, suturing, and vaccination at the hospital, the biological membrane dressing prepared according to Example 1 of this invention was applied externally that afternoon. The wound was deep and accompanied by swelling. The swelling significantly decreased after two days of application, and the wound healed in ten days. A photograph taken 19 days later showed complete healing, with only a small mark remaining due to the scab not falling off naturally. (Refer to...) Figure 9 .

[0113] Case Thirteen (Old Abrasions) The patient sustained abrasions while fishing in a river on August 13, 2025. After anti-inflammatory treatment and disinfection with iodine, the patient used the biofilm dressing prepared in Example 4 of this invention and recovered after five days.

[0114] The present invention and its embodiments have been described above. This description is not restrictive, and the embodiments shown are merely one example of the present invention. The actual structure is not limited to these examples. In particular, the herbal ingredients and proportions can be flexibly adjusted according to the type of injury or illness to achieve the best effect. In conclusion, if those skilled in the art are inspired by this description and, without departing from the spirit of the invention, design similar structures and embodiments without creative intent, all such designs should fall within the protection scope of the present invention.

Claims

1. A biofilm dressing, characterized in that, It contains the following raw materials by weight percentage: 20-100% egg white, 0-5% fibrinolytic enzyme, 0-5% soybean small molecule peptides, 0-10% Bletilla striata powder, 0-1.5% carboxymethyl cellulose and one of the following traditional Chinese medicines; Traditional Chinese Medicine I: 0-3% Polygonum multiflorum juice, 0-3% Sophora flavescens juice, 0-2% Borneol powder; Traditional Chinese Medicine II: 0-1% Cirsium japonicum juice, 0-1% Polygonum aviculare juice, 0-2% Portulaca oleracea, 0-2% Borneol powder; Traditional Chinese Medicine III: 0-1% thistle juice, 0-2% purslane, 0-2% borneol powder; Traditional Chinese Medicine IV: 1-3% Panax notoginseng powder, 1-2% Carthamus tinctorius, 0-2% Borneol powder; Traditional Chinese medicine V: 0-3% Sophora flavescens juice, 0-3% Phellodendron chinense juice, 0-2% Borneol powder; Traditional Chinese Medicine VI: 0-30% Paulownia root, 0-30% Rose leaf, 0-30% Gardenia root, 0-30% Crab, 0-2% Borneol powder; Traditional Chinese medicine VII: 0-2% thistle juice, 0-40% honey, or 0-40% aloe vera gel; Traditional Chinese medicine VIII: 10-40% radish peel, 10-40% rose flowers and leaves, 0-2% borneol powder; Traditional Chinese medicine IX: 0-3% Cirsium japonicum juice, 0-3% Polygonum aviculare juice, 0-3% Sophora flavescens juice; Chinese herbal medicine X: 0-10% curcumin, 0-10% dragon's blood, 0-10% astragalus, 0-2% thistle juice, 0-2% purslane, 0-2% borneol powder.

2. The biofilm dressing according to claim 1, characterized in that, It contains the following raw materials by weight percentage: 20-100% egg white, 0-5% fibrinolytic enzyme, 0-5% soybean small molecule peptides, 0-3% thistle juice, 0-3% angelica juice, 0-3% sophora root juice, 0-10% bletilla powder, 0-1.5% sodium carboxymethyl cellulose.

3. The biofilm dressing according to claim 1, characterized in that, It contains the following raw materials by weight percentage: 20-80% egg white, 0-10% Bletilla striata, 0-5% soybean small molecule peptides, 0-3% Cirsium japonicum juice, 0-3% Polygonum aviculare juice, 0-2% Sophora flavescens juice, 20-60% honey or 20-60% aloe vera gel.

4. A method for preparing a biofilm dressing as described in claims 1-3, characterized in that, Includes the following steps: S1. Preparation of Chinese herbal medicines: Take fresh Chinese herbal medicine raw materials, extract the juice and centrifuge to obtain a clear liquid of Chinese herbal medicine juice; or further process the clear liquid of Chinese herbal medicine juice into freeze-dried powder; S2. Processing egg whites: Take fresh eggs, sterilize the eggshells, and then extract the egg whites. Sterilize the egg whites or further process them into freeze-dried powder. S3. Mixing: Mix the Chinese herbal medicine obtained in step S1, the egg white obtained in step S2, and the soybean small molecule peptides in a certain proportion to prepare a biofilm dressing.

5. The method for preparing a biofilm dressing according to claim 4, characterized in that, It also includes step S4: the biofilm dressing obtained in step S3 is made into a freeze-dried powder, which is then mixed with purified water to form a gel before use.

6. The method for preparing a biofilm dressing according to claim 4, characterized in that, In step S2, pasteurization is used to sterilize the egg whites.

7. The use of a biofilm dressing as described in claims 1-3 in the preparation of a medicament or medical dressing for treating skin or subcutaneous tissue trauma; Or its use in the preparation of drugs or medical dressings for inhibiting scar hyperplasia; Or its application in the preparation of skin-repairing cosmetic products; Or its application in the treatment of sprains; Or its application in the treatment of fracture healing; Or its application in traditional Chinese medicine's treatment of internal diseases externally, external diseases externally, and simultaneous internal and external treatment.

8. The application according to claim 7, characterized in that, The skin or subcutaneous tissue traumas include burns, surgical incisions, abrasions, chronic skin ulcers, diabetic foot, urticaria lesions, herpes zoster lesions, frostbite, penetrating injuries, lacerations, animal bites, and fungal infections.

9. The application according to claim 7, characterized in that, When the biofilm dressing is used to inhibit scar hyperplasia, a biofilm dressing containing carboxymethyl cellulose or Bletilla striata powder is used.

10. The application according to claim 7, characterized in that, When the biofilm dressing is used in skin repair cosmetic products, a biofilm dressing containing honey or aloe vera juice is used.

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