Liquid taking needle structure, liquid storage module and biochemical reaction equipment

Abstract

The invention discloses a liquid taking needle structure, a liquid storage module and biochemical reaction equipment, the liquid taking needle structure comprises a liquid taking needle fixing seat, a hard outer sleeve, a sleeve guide seat and a fluid pipe, and the liquid taking needle fixing seat is provided with at least one fixing hole; the outer sleeve penetrates through the fixing hole; the sleeve guide seat is connected with the liquid taking needle fixing seat, the sleeve guide seat is arranged on the outer sides of all the outer sleeves in a sleeving mode, the ends, away from the liquid taking needle fixing seat, of the outer sleeves extend out of the sleeve guide seat, and the sleeve guide seat is used for keeping the outer sleeves vertical; the fluid tube is arranged in the outer sleeve, and the fluid tube and the outer sleeve form a liquid taking needle. According to the liquid taking needle structure, the liquid taking needle is high in perpendicularity and not prone to being bent, the overall structure is simple, the machining difficulty of all parts is low, batch machining and production are easy, and cost is low.

Description

Technical Field

[0001] This invention relates to the field of liquid transfer technology, and in particular to a liquid sampling needle structure, a liquid storage module, and a biochemical reaction device. Background Technology

[0002] With the continuous development of sequencing technology, gene sequencing has broad application prospects in fields such as early disease screening, microbiology, and genetic testing, and the market demand for sequencers is also increasing. As the core module of a gene sequencer—the reagent storage module—its core component is the retrieval needle used to extract liquids such as sequencing reagents from the kit.

[0003] Existing sampling needles are prone to damage to the needle or instrument during the sampling and dispensing process, resulting in sequencing failure. Moreover, since the length of the sampling needle is usually long, it is difficult to ensure verticality. In addition, during the sampling or dispensing process, the sampling needle is prone to scraping the needle hole, which can easily introduce contaminants into the reagent kit and affect the test quality. Cleaning the sampling needle with a complex cleaning mechanism increases the structural complexity and cost. Summary of the Invention

[0004] To address at least one of the above-mentioned defects, it is necessary to propose a liquid collection needle structure.

[0005] In addition, embodiments of this application also provide a liquid storage module and a biochemical reaction device that utilize the aforementioned liquid sampling needle structure.

[0006] In a first aspect, embodiments of this application provide a liquid-collecting needle structure, comprising: a liquid-collecting needle fixing seat, at least one rigid outer tube, a cannula guide seat, and at least one fluid tube. The liquid-collecting needle fixing seat has at least one fixing hole; the outer tube is disposed through the fixing hole; the cannula guide seat is connected to the liquid-collecting needle fixing seat, the cannula guide seat is sleeved on the outside of all the outer tubes, and one end of the outer tube away from the liquid-collecting needle fixing seat extends out of the cannula guide seat, the cannula guide seat enables the outer tube to remain vertical; the fluid tube is disposed inside the outer tube, and the fluid tube and the outer tube constitute a liquid-collecting needle.

[0007] In some possible embodiments, the liquid collection needle holder and the cannula are an integral structure.

[0008] In some possible embodiments, the outer tube is made of metal, and / or the fluid tube is made of plastic.

[0009] In some possible embodiments, the sleeve guide seat includes a guide seat body, the guide seat body includes a first end and a second end disposed opposite to each other, and a plurality of guide holes corresponding one-to-one with the fixing holes are provided through the first end and the second end, and the outer sleeve passes through the guide holes.

[0010] In some possible embodiments, the end face of the first end is recessed towards the second end to form a mounting groove, and the liquid collection needle fixing seat is detachably installed in the mounting groove; the first end is provided with at least one positioning hole corresponding to the side wall of the mounting groove, and the liquid collection needle structure also includes a connector, the connector extending into the positioning hole and abutting against the liquid collection needle fixing seat, so that the sleeve guide seat is detachably connected to the liquid collection needle fixing seat.

[0011] Secondly, embodiments of this application provide a liquid storage module, including: a liquid storage tank, a driving mechanism disposed on the liquid storage tank, and at least one liquid-taking needle structure disposed on the driving mechanism. The liquid-taking needle structure is a liquid-taking needle structure as described above. The liquid storage tank has a receiving cavity for accommodating a liquid storage box, and the driving mechanism is used to drive the liquid-taking needle structure to move up and down to extend into or out of the liquid storage box located in the receiving cavity.

[0012] In some possible embodiments, the liquid storage tank has a liquid extraction hole communicating with the receiving cavity, and the driving mechanism has an end cap that is sleeved on the liquid extraction needle structure. When the driving mechanism drives the liquid extraction needle structure to extend from the liquid extraction hole into the receiving cavity, the end cap closes at the liquid extraction hole.

[0013] In some possible embodiments, the liquid extraction hole is provided with a guide hole sleeve, the guide hole sleeve extends out of the top of the liquid storage tank, and the end cap can be closed on the guide hole sleeve.

[0014] In some possible embodiments, the liquid storage chamber includes an inner wall and an outer wall sleeved on the outside of the inner wall, the inner wall forming the receiving cavity, and an insulation cavity between the inner wall and the outer wall, wherein an insulation layer is provided in the insulation cavity; the liquid storage module further includes a limiting structure disposed on the liquid storage chamber, the limiting structure being used to limit the movement distance of the liquid-taking needle structure along the lifting direction.

[0015] Thirdly, embodiments of this application provide a biochemical reaction device, including a liquid usage module and a liquid storage module as described above, wherein the liquid extraction needle structure is connected to the liquid usage module to add liquid extracted from the storage box into the liquid usage module.

[0016] The liquid collection needle structure provided in this application embodiment is simple in structure, the processing difficulty of each part is low, it is easy to mass-produce, and the cost is low. By designing a rigid outer tube on the outside of the liquid collection needle, and cooperating with the sleeve guide seat set on the outside of the outer tube, (1) the liquid collection needle can be protected and the risk of accidental damage to the liquid collection needle can be reduced; (2) the verticality of the liquid collection needle can be guaranteed, and it is not easy to bend when the needle pierces the sealing film of the liquid storage box, which can avoid the liquid collection needle from scratching the liquid storage box and generating debris; (3) due to the high verticality of the liquid collection needle, the needle position is more accurate, and the dead volume of the liquid storage box can be made very small, saving reagents; (4) due to the high verticality of the liquid collection needle and the outer tube, during the liquid collection process, the outer wall of the outer tube carrying liquid has no risk of scraping the liquid collection hole of the liquid storage box, thereby reducing the risk of the liquid collection hole of the liquid storage box being contaminated by liquid, and thus reducing the risk of contaminants being brought into the liquid storage box during the lifting and lowering of the liquid collection needle structure; (5) there is no need to set an additional cleaning mechanism on the outer wall of the liquid collection needle, which reduces the complexity of the liquid collection needle structure.

[0017] In addition, in the liquid storage module, an end cap is set on the drive mechanism. When the liquid needle structure descends into place, the end cap can effectively cover and block the liquid extraction hole of the liquid storage tank, further preventing impurities and other contaminants in the air from entering the liquid storage tank. Furthermore, for refrigerated liquid storage tanks with a refrigeration module, adding an end cap can also effectively prevent cold air leakage and ensure the liquid storage temperature. Attached Figure Description

[0018] To more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the embodiments of the present invention will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0019] Figure 1 This is a system block diagram of a biochemical reaction apparatus provided in one embodiment of this application.

[0020] Figure 2 This is a schematic diagram of the structure of a liquid storage module provided in an embodiment of this application.

[0021] Figure 3 for Figure 2 Sectional view along III-III.

[0022] Figure 4 for Figure 3 Enlarged view of section A.

[0023] Figure 5 for Figure 2 A schematic diagram of the liquid extraction needle structure.

[0024] Figure 6 for Figure 5A schematic diagram of the liquid extraction needle structure from another perspective.

[0025] Figure 7 for Figure 5 Cross-sectional view along the middle section VII-VII.

[0026] Figure 8 for Figure 7 Enlarged view of section B.

[0027] Figure 9 for Figure 5 Cross-sectional view along the middle IX-IX.

[0028] Figure 10 for Figure 5 A schematic diagram of the structure of the liquid extraction needle holder.

[0029] Figure 11 for Figure 5 A schematic diagram of the structure of the guide seat for the middle sleeve.

[0030] Figure 12 for Figure 11 Cross-sectional view along XII-XII.

[0031] Explanation of main component symbols

[0032] Biochemical reaction equipment 1000

[0033] Liquid storage module 100

[0034] Liquid collection needle structure 10

[0035] Liquid collection needle holder 1

[0036] Fixing hole 11

[0037] Base 12

[0038] Connecting part 13

[0039] Mounting hole 14

[0040] Connector 15

[0041] Outer tube 2

[0042] Casing guide seat 3

[0043] First end 31

[0044] Second end 32

[0045] Guide hole 33

[0046] Mounting slot 34

[0047] Positioning hole 35

[0048] Fluid tube 4

[0049] Liquid collection end 41

[0050] Positioning component 5

[0051] Liquid storage tank 20

[0052] Inner wall 201

[0053] Outer wall 202

[0054] Insulation cavity 203

[0055] Liquid intake hole 204

[0056] Guide hole sleeve 205

[0057] Warehouse 206

[0058] Drive mechanism 30

[0059] Driver board 301

[0060] Guide column 302

[0061] Drive component mounting plate 303

[0062] Drive component 304

[0063] Lifting shaft 305

[0064] Reception cavity 40

[0065] 50 reservoir

[0066] 60 syringes

[0067] Insulation layer 70

[0068] End cap 80

[0069] Limiting structure 90

[0070] Pillar 901

[0071] First limiting part 902

[0072] Second limiting part 903

[0073] 904 baffle

[0074] First direction a

[0075] Second direction b

[0076] Liquid Use Module 200

[0077] The following detailed description, in conjunction with the accompanying drawings, will further illustrate the present invention. Detailed Implementation

[0078] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0079] It should be noted that when a component is described as "fixed to" or "mounted to" another component, it can be directly on the other component or may be interspersed with an intermediate component. When a component is described as "set to" another component, it can be directly set on the other component or may be interspersed with an intermediate component. The term "and / or" as used herein includes all and any combination of one or more of the associated listed items.

[0080] When using aspiration needles in existing gene sequencers to extract liquids (such as reagents required for gene sequencing), it is easy to damage the needle or the instrument, resulting in sequencing failure. In addition, the needles are relatively long and it is difficult to maintain verticality. Furthermore, contamination can easily occur during the extraction process, affecting sequencing quality.

[0081] To address the above issues, this application provides a liquid extraction needle structure. This structure can be used in the liquid storage module of a gene sequencer to extract liquid from the reservoir. Applying this liquid extraction needle structure effectively reduces the risk of damage to the needle and instrument, as well as sequencing failure. Furthermore, the high verticality of the needle structure makes it less prone to bending, reducing contamination and improving sequencing quality. It is understood that this liquid extraction needle structure can also be used in other biochemical reaction equipment to extract liquids required for biochemical reactions. Besides its application in gene sequencing, this liquid extraction needle structure can also be used in in vitro diagnostic products requiring sample loading or in other instruments and systems within clinical laboratory self-built projects.

[0082] Please see Figure 1 The present application provides a biochemical reaction device 1000, which includes a liquid storage module 100 and a liquid usage module 200. The liquid storage module 100 is used to add liquids required for biochemical reactions (such as reagents required for gene sequencing) to the liquid usage module 200, and the liquid usage module 200 is used to perform biochemical reactions, such as gene sequencing reactions.

[0083] Please refer to both together. Figure 2 and Figure 3As shown, the liquid storage module 100 includes a liquid sampling needle structure 10, a liquid storage tank 20, and a drive mechanism 30. The liquid storage tank 20 has a receiving cavity 40 for accommodating a liquid storage box 50. The drive mechanism 30 is used to drive the liquid sampling needle structure 10 to move up and down, extending into or out of the liquid storage box 50 located in the receiving cavity 40, thereby extracting liquid from the liquid storage box 50. Specifically, the liquid sampling needle structure 10 is connected to the liquid use module 200, wherein the drive mechanism 30 drives the liquid sampling needle structure 10 to extend into the liquid storage box 50 in the liquid storage tank 20 and extract the required liquid from the liquid storage box 50. The liquid extracted into the liquid sampling needle structure 10 will be further transferred into the liquid use module 200 to complete the biochemical reaction.

[0084] Please see Figures 4 to 6 As shown, please refer to the following: Figure 3 The liquid-collecting needle structure 10 provided in this embodiment includes: a liquid-collecting needle fixing seat 1, at least one rigid outer tube 2, a tube guide seat 3, and at least one fluid tube 4. The liquid-collecting needle fixing seat 1 has at least one fixing hole 11. The outer tube 2 passes through the fixing hole 11. The tube guide seat 3 is connected to the liquid-collecting needle fixing seat 1, and is sleeved on the outside of all the outer tubes 2, with one end of the outer tube 2 away from the liquid-collecting needle fixing seat 1 extending out of the tube guide seat 3. The tube guide seat 3 is used to keep the outer tube 2 vertical. The fluid tube 4 is disposed inside the outer tube 2. The fluid tube 4 and the outer tube 2 constitute a liquid-collecting needle 60, used to extend into the liquid storage box 50 to extract liquid.

[0085] like Figure 7 As shown, please combine them together. Figure 4 and Figure 5 The liquid collection needle holder 1 includes a base body 12 and a connecting portion 13 disposed on the base body 12. Multiple fixing holes 11 are formed through the base body 12 and the connecting portion 13. Each fixing hole 11 contains an outer sleeve 2, and each outer sleeve 2 contains a fluid tube 4, thereby forming multiple liquid collection needles 60 fixed on the liquid collection needle holder 1. The liquid collection needles 60 extend along a first direction a and along a second direction b perpendicular to the first direction a. The size of the connecting portion 13 is smaller than the size of the base body 12, thus forming a stepped structure. A sleeve guide seat 3, fitted over the outside of all the liquid collection needles 60, is mounted on the connecting portion 13.

[0086] In some embodiments, a mounting hole 14 is provided along the edge of the seat 12 through the first direction a, so that the seat 12 can be detachably mounted on the drive mechanism 30 by means of a connector 15, thereby realizing the fixation of the liquid-collecting needle structure 10 on the drive mechanism 30 (see reference). Figure 2 ).

[0087] In some embodiments, the material of the liquid collection needle holder 1 may be metal. The material of the liquid collection needle holder 1 may also be a high-strength rigid plastic, etc.

[0088] like Figures 4 to 6 As shown, the rigid outer sleeve 2 has high strength, which can protect the internal fluid tube 4 and guide its straightness. The resulting sampling needle 60 has high perpendicularity and strength, effectively reducing the bending of the sampling needle 60. In addition, adding a rigid outer sleeve 2 to the outside of the fluid tube 4 makes it easier to pierce the sealing film of the liquid storage box 50, which can reduce the requirements for the hardness and wall thickness of the fluid tube 4, and reduce the forming requirements of the fluid tube 4.

[0089] In some embodiments, the fluid tube 4 is detachably installed inside the outer tube 2.

[0090] In some embodiments, the outer tube 2 and the liquid collection needle holder 1 can be an integral structure. For example, the outer tube 2 and the liquid collection needle holder 1 can be fixed together by processes such as cold assembly or laser welding. By forming the outer tube 2 and the liquid collection needle holder 1 into an integral structure, it is convenient to detachably install the fluid tube 4 inside the outer tube 2, and to facilitate the replacement of the fluid tube 4. In addition, forming the outer tube 2 and the liquid collection needle holder 1 into an integral structure can ensure the perpendicularity of the outer tube 2, thereby improving the perpendicularity of the liquid collection needle 60.

[0091] In some embodiments, the outer tube 2 may be made of metal, which can further improve the rigidity and hardness of the fluid tube 4. It is understood that the outer tube 2 may also be made of rigid plastic.

[0092] In some embodiments, when the outer tube 2 is made of metal, it can be connected to the fixing hole 11 of the liquid collection needle fixing seat 1 by cold assembly or welding, which is a simple connection method. It is understood that when the outer tube 2 is made of rigid plastic, it can also be integrally connected to the liquid collection needle fixing seat 1 by welding or bonding.

[0093] The fluid tube 4 can be made of plastic (e.g., polytetrafluoroethylene, PTFE). Understandably, the material of the fluid tube 4 should be chosen to be resistant to corrosion by the extracted liquid. Specifically, in conjunction with... Figure 1 As shown, the fluid tube 4 is connected to the liquid use module 200. When the fluid tube 4 is made of plastic, the plastic fluid tube 4 can be bent at will, which facilitates the connection with the liquid use module 200 and makes reasonable use of space.

[0094] In some embodiments, the fluid tube 4 and the outer tube 2 are connected by a rolling compression connection, so that the outer tube 2 and the fluid tube 4 are tightly connected, and there are almost no gaps between the outer wall of the fluid tube 4 and the inner wall of the outer tube 2, so as to prevent liquid from entering the gaps during the liquid collection process and affecting the accuracy of liquid collection.

[0095] like Figure 7and Figure 8 As shown, combined Figures 4 to 6 The fluid tube 4 is roughly a hollow columnar structure, and the inner wall of the outer sleeve 2 and the outer wall of the fluid tube 4 have a contoured structure, which is also columnar.

[0096] In some embodiments, the liquid-collecting end 41 of the fluid tube 4 is flush with or extends beyond the end of the outer tube 2 away from the liquid-collecting needle holder 1. This prevents contamination of the inside of the outer tube 2 during liquid collection.

[0097] In some embodiments, the liquid extraction end 41 of the fluid tube 4 has an inclined surface to form an oblique opening with a pointed tip, which facilitates piercing the sealing membrane of the liquid storage box 50 to extract the reagent.

[0098] like Figures 9 to 12 As shown, combined Figures 4 to 6 The cannula guide seat 3 includes a first end 31 and a second end 32 arranged opposite to each other. Multiple guide holes 33, corresponding one-to-one with the fixing holes 11, are provided through the first end 31 and the second end 32. The outer sleeve 2 passes through and extends out of the guide holes 33. Specifically, the cannula guide seat 3 can be a solid structure, with the guide holes 33 formed on the solid cannula guide seat 3. Inserting the liquid-collecting needle 60 into the guide holes 33 can further improve the verticality of the liquid-collecting needle 60 and prevent accidental bending of the liquid-collecting needle 60 during liquid collection.

[0099] In some embodiments, the cannula guide seat 3 and the liquid collection needle fixing seat 1 are detachably connected. Specifically, the cannula guide seat 3 is detachably connected to the liquid collection needle fixing seat 1 via a first end 31. The end face of the first end 31 is recessed towards the second end 32 to form a mounting groove 34, and the liquid collection needle fixing seat 1 is detachably installed in the mounting groove 34.

[0100] In some embodiments, the first end 31 has at least one positioning hole 35 on the side wall corresponding to the mounting groove 34. The liquid-taking needle structure 10 also includes a positioning member 5, which extends into the positioning hole 35 and abuts against the side wall of the liquid-taking needle fixing seat 1, so that the sleeve guide seat 3 can be detachably connected to the liquid-taking needle fixing seat 1. Specifically, the positioning member 5 can be a screw, and the positioning hole 35 has an internal thread.

[0101] In some embodiments, along the first direction a, the length of the cannula guide seat 3 can be 1 / 3 to 3 / 4 of the length of the outer cannula 2. By limiting the length of the cannula guide seat 3 covering the liquid retrieval needle 60, the verticality of the liquid retrieval needle 60 can be ensured without affecting the insertion of the liquid retrieval needle 60 into the liquid storage box 50 for liquid retrieval.

[0102] In some embodiments, the sleeve guide seat 3 may be made of plastic and obtained by injection molding.

[0103] Please refer to it again. Figures 2 to 4The drive mechanism 30 includes a drive plate 301, a guide post 302 disposed on the drive plate 301, a drive component mounting plate 303 disposed on the guide post 302, a drive component 304 disposed on the drive component mounting plate 303, and a lifting shaft 305 disposed on the output shaft of the drive component 304. The lifting shaft 305 is connected to the drive plate 301, and the drive plate 301 is provided with at least one liquid-collecting needle structure 10. Driven by the drive component 304, the drive plate 301 can be driven, thereby driving the liquid-collecting needle structure 10 to move up and down.

[0104] In some embodiments, the connector 15 passes through the mounting hole 14 on the liquid needle holder 1 and is fixed to the drive plate 301.

[0105] The liquid storage tank 20 includes an inner wall 201 and an outer wall 202 sleeved on the outside of the inner wall 201. The inner wall 201 forms a receiving cavity 40, and an insulation cavity 203 is provided between the inner wall 201 and the outer wall 202. An insulation layer 70 is provided inside the insulation cavity 203. The liquid storage tank 20 is configured with an insulation layer 70, which can achieve heat preservation of the liquid in the liquid storage box 50 and improve the heat preservation effect. It is especially suitable for refrigerated liquid storage tanks with a refrigeration module.

[0106] In some embodiments, the liquid storage tank 20 is provided with a liquid extraction hole 204 communicating with the receiving cavity 40. The driving mechanism 30 drives the liquid extraction needle structure 10 to extend into the liquid extraction hole 204 and further into the liquid storage box 50 located in the receiving cavity 40 to extract liquid. Specifically, the liquid extraction hole 204 penetrates the inner wall 201 and the outer wall 202, and each liquid extraction needle structure 10 installed on the corresponding driving plate 301 is provided with a liquid extraction hole 204.

[0107] In some embodiments, the liquid storage module 100 further includes an end cap 80 disposed on the drive mechanism 30. When the drive mechanism 30 drives the liquid-taking needle structure 10 to extend into the receiving cavity 40 through the liquid-taking hole 204, the end cap 80 can close the liquid-taking hole 204, thereby sealing the liquid storage tank 20 and reducing the entry of impurities and other pollutants in the air into the liquid storage tank 20, thus reducing the risk of liquid contamination. In addition, for refrigerated liquid storage tanks equipped with a refrigeration module, sealing the liquid-taking hole 204 by the end cap 80 can effectively reduce the leakage of cold air in the liquid storage tank 20, ensure the liquid storage temperature, and also prevent condensate from falling into the receiving cavity 40.

[0108] In some embodiments, a guide sleeve 205 is provided inside the liquid inlet 204, and the guide sleeve 205 extends out of the top of the liquid storage tank 20, so that the end cap 80 can be closed on the guide sleeve 205 to improve the sealing effect.

[0109] The liquid storage module 100 also includes a limiting structure 90 disposed on the liquid storage tank 20, which limits the movement distance of the liquid-taking needle structure 10 along the lifting direction (i.e., the first direction a).

[0110] In some embodiments, the limiting structure 90 includes a support post 901 disposed on the liquid storage tank 20, a first limiting portion 902 disposed on the support post 901 near the liquid storage tank 20, a second limiting portion 903 disposed on the support post 901 away from the liquid storage tank 20, and a baffle 904 disposed on the drive plate 301. When the drive mechanism 30 drives the liquid-taking needle structure 10 to extend into the liquid storage tank 20, during the descent process, when the baffle 904 moves to the first limiting portion 902, the liquid-taking needle structure 10 descends to its final position. When the drive mechanism 30 drives the liquid-taking needle structure 10 to rise and exit the liquid storage tank 20, during the rising process, when the baffle 904 moves to the second limiting portion 903, the liquid-taking needle structure 10 rises to its final position. By setting the limiting structure 90, the accuracy of the moving distance of the liquid-taking needle structure 10 can be improved, and collisions between the liquid-taking needle 60 and the bottom of the liquid storage box 50 can be avoided, preventing damage.

[0111] Please refer to it again. Figure 2 and Figure 3 The liquid storage chamber 20 can be provided with multiple receiving cavities 40, which can then accommodate multiple liquid storage boxes 50. Each receiving cavity 40 is equipped with a corresponding drive mechanism 30 and a liquid extraction needle structure 10. By integrating multiple sets of liquid extraction needle structures 10 and drive mechanisms 30 onto a single liquid storage chamber 20, the extraction of various liquids can be achieved, improving the efficiency of liquid extraction. In some embodiments, the liquid storage chamber 20 is provided with a door 206 corresponding to each receiving cavity 40. During liquid extraction, the door 206 can be closed to isolate external contamination; after opening the door 206, the liquid storage box 50 can be replaced.

[0112] In use: The drive mechanism 30 raises the liquid-collecting needle structure 10 to the second limiting part 903, placing the sealed liquid storage box 50 into the receiving cavity 40 of the liquid storage chamber 20; then, the drive mechanism 30 lowers the liquid-collecting needle structure 10, passing through the guide hole sleeve 205 into the receiving cavity 40. The tip of the liquid-collecting needle 60 pierces the sealing film of the liquid storage box 50 and continues to descend until it stops at the first limiting part 902. At this time, the end cap 80 completely covers the guide hole sleeve 205 to seal the liquid storage chamber 20, and the liquid-collecting needle structure 10 begins to draw liquid as needed. Since the fluid tube 4 in the liquid-collecting needle 60 is connected to the liquid use module 200, after the liquid is extracted into the fluid tube 4, it can further enter the liquid use module 200 to complete the subsequent biochemical reaction. After the liquid collection is completed, the drive mechanism 30 raises the liquid-collecting needle structure 10 to exit the liquid storage chamber 20.

[0113] The liquid-collecting needle structure 10 provided in this embodiment has a simple structure, low processing difficulty of each part, is easy to mass-produce, and has low cost. By designing a rigid outer sleeve 2 on the outside of the fluid tube 4, and cooperating with the sleeve guide seat 3 set on the outside of the outer sleeve 2, (1) the liquid-collecting needle can be protected and the risk of accidental damage to the liquid-collecting needle 60 can be reduced; (2) the verticality of the liquid-collecting needle 60 can be guaranteed, and it is not easy to bend when the needle pierces the sealing film of the liquid storage box 50, which can prevent the liquid-collecting needle 60 from scratching the liquid storage chamber 20 and generating debris; (3) because the verticality of the liquid-collecting needle 60 is high, the needle position is more accurate, and the dead volume of the liquid storage box 50 can be reduced. (4) Because the fluid tube 4 and the outer tube 2 are highly perpendicular, during the liquid collection process, the outer wall of the outer tube 2 carries liquid and there is no risk of scratching the liquid collection hole 204 of the liquid storage tank 20, thereby reducing the risk of the liquid collection hole 204 of the liquid storage tank 20 being contaminated by liquid, and reducing the risk of contaminants being brought into the liquid storage box 50 during the lifting and lowering of the liquid collection needle structure 10; (5) There is no need to set an additional cleaning mechanism on the outer wall of the liquid collection needle 60, which reduces the complexity of the liquid collection needle structure 10.

[0114] In addition, in the liquid storage module 100, an end cap 80 is provided on the drive mechanism 30. When the liquid needle structure 10 descends into position, the end cap 80 can effectively cover and block the liquid outlet 204 of the liquid storage tank 20, further preventing impurities and other contaminants in the air from entering the liquid storage tank 20. Furthermore, for refrigerated liquid storage tanks with a refrigeration module, adding the end cap 80 can also effectively prevent cold air leakage and ensure the liquid storage temperature.

[0115] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. A liquid collection needle structure, characterized in that, include: The liquid collection needle holder has at least one fixing hole; At least one rigid outer tube is provided, which extends through the fixing hole; A cannula guide seat is connected to the liquid-collecting needle fixing seat. The cannula guide seat is sleeved on the outside of all the outer cannulas, and one end of the outer cannula away from the liquid-collecting needle fixing seat extends out of the cannula guide seat. The cannula guide seat enables the outer cannula to remain vertical. At least one fluid tube is disposed inside the outer sleeve, and the fluid tube and the outer sleeve together form a liquid collection needle.

2. The liquid-collecting needle structure as described in claim 1, characterized in that, The liquid collection needle holder and the cannula are an integral structure.

3. The liquid collection needle structure as described in claim 1, characterized in that, The outer tube is made of metal, and / or the fluid tube is made of plastic.

4. The liquid collection needle structure as described in claim 1, characterized in that, The sleeve guide seat includes a guide seat body, which includes a first end and a second end that are disposed opposite to each other. A plurality of guide holes corresponding one-to-one with the fixing holes are provided through the first end and the second end, and the outer sleeve passes through the guide holes.

5. The liquid collection needle structure as described in claim 4, characterized in that, The end face of the first end is recessed towards the second end to form a mounting groove, and the liquid collection needle fixing seat can be detachably installed in the mounting groove; The first end is provided with at least one positioning hole corresponding to the side wall of the mounting groove. The liquid-taking needle structure also includes a connector. The connector extends into the positioning hole and abuts against the liquid-taking needle fixing seat, so that the sleeve guide seat can be detachably connected to the liquid-taking needle fixing seat.

6. A liquid storage module, characterized in that, It includes: a liquid storage tank, a drive mechanism disposed on the liquid storage tank, and at least one liquid-collecting needle structure disposed on the drive mechanism, wherein the liquid-collecting needle structure is the liquid-collecting needle structure as described in any one of claims 1 to 5. The liquid storage chamber has a receiving cavity for accommodating the liquid storage box, and the driving mechanism is used to drive the liquid-taking needle structure to move up and down to extend into or out of the liquid storage box located in the receiving cavity.

7. The liquid storage module as described in claim 6, characterized in that, The liquid storage tank has a liquid extraction hole that communicates with the receiving cavity. The driving mechanism has an end cap that is fitted onto the liquid extraction needle structure. When the driving mechanism drives the liquid extraction needle structure to extend into the receiving cavity through the liquid extraction hole, the end cap closes onto the liquid extraction hole.

8. The liquid storage module as described in claim 7, characterized in that, The liquid extraction hole is provided with a guide hole sleeve, which extends out of the top of the liquid storage tank, and the end cap can be closed on the guide hole sleeve.

9. The liquid storage module as described in claim 6, characterized in that, The liquid storage tank includes an inner wall and an outer wall sleeved on the outside of the inner wall. The inner wall forms the receiving cavity, and there is a heat-insulating cavity between the inner wall and the outer wall. A heat-insulating layer is provided inside the heat-insulating cavity. The liquid storage module also includes a limiting structure disposed on the liquid storage tank, the limiting structure being used to limit the movement distance of the liquid-taking needle structure along the lifting direction.

10. A biochemical reaction apparatus, characterized in that, The system includes a liquid use module and a liquid storage module as described in any one of claims 6 to 9, wherein the liquid dispensing needle structure is connected to the liquid use module to add liquid extracted from the storage box to the liquid use module.

Images