Biological information acquisition and analysis device

Abstract

The invention relates to the technical field of bioinformatics, in particular to a biological information acquisition and analysis device which comprises an automatic glue filling module and a capillary electrophoresis module, and a laser detection module is arranged at the tail end of the capillary electrophoresis module. An automatic sample injection module for receiving a to-be-detected sample solution and loading the to-be-detected sample solution into the capillary electrophoresis module is arranged at one end, far away from the laser detection module, of the capillary electrophoresis module; a viscosity detection and regulation module is arranged at one end, far away from the capillary electrophoresis module, of the automatic sample injection module; the viscosity detection and regulation and control module comprises a detection unit for detecting the viscosity of a to-be-detected sample solution and a regulation and control unit for adding a viscosity regulator to regulate and control the viscosity of the to-be-detected sample solution; through cooperation of the viscosity detection unit and the regulation and control unit, viscosity data of a to-be-detected sample solution is collected and analyzed in real time, and the viscosity is precisely regulated and controlled to a proper interval, so that gene analysis result deviation caused by viscosity difference of the sample solution is eliminated.

Description

Technical Field

[0001] This invention relates to the field of bioinformatics technology, specifically to a bioinformatics acquisition and analysis device. Background Technology

[0002] A bioinformatics acquisition and analysis device is typically a detection system that integrates sensor technology, signal processing algorithms, and data analysis modules. It is primarily designed to extract specific physiological or pathological indicators from biological samples such as blood, tissue, sweat, or electrical signals.

[0003] Existing gene analyzers, such as the ABI Gene Analyzer 3130, mainly consist of core components including an automated gel dispensing device, an automated microplate sample loading system, a four-channel electrophoresis capillary, a photoelectric detection unit, a computer workstation, and supporting bioinformatics analysis software. First, the automated gel dispensing device precisely fills the separating gel into the capillary. Then, the automated microplate sample loading system loads the pre-treated sample solution containing fluorescently labeled nucleic acid molecules into the electrophoresis capillary. Under the electric field driven by the capillary electrophoresis module, DNA fragments are efficiently separated according to their molecular weight and charge differences. During separation, the photoelectric detection unit excites the fluorescently labeled nucleic acid fragments in the sample and captures the fluorescence signal. The captured fluorescence signal is transmitted to the computer workstation, where it is processed by the accompanying software for bioinformatics analysis, ultimately outputting the gene information analysis results of the sample.

[0004] Compared to conventional electrophoresis, capillary electrophoresis offers advantages such as higher separation efficiency, faster analysis speed, minimal sample volume, and higher automation. However, during capillary electrophoresis, the physical properties of the sample solution directly affect the sample injection volume and separation stability within the capillary. The viscosity of the sample solution can influence the separation of adjacent base pairs (SNPs) or small DNA fragments, thus affecting the final genetic information analysis results. Therefore, it is necessary to propose a bioinformatics acquisition and analysis device to address these shortcomings. Summary of the Invention

[0005] To address the aforementioned issues, this invention provides a bioinformatics acquisition and analysis device. Through the collaboration of a viscosity detection unit and a control unit, it acquires and analyzes the viscosity data of the sample solution in real time, precisely controlling its viscosity to a suitable range, thereby eliminating deviations in gene analysis results caused by differences in sample solution viscosity.

[0006] To achieve the above objectives, the technical solution of the present invention is as follows: a bioinformatics acquisition and analysis device, comprising an automatic gel dispensing module and a capillary electrophoresis module, wherein a laser detection module is provided at the end of the capillary electrophoresis module, an automatic sample injection module is provided at the end of the capillary electrophoresis module away from the laser detection module for receiving the sample solution to be tested and loading it into the capillary electrophoresis module, and a viscosity detection and control module is provided at the end of the automatic sample injection module away from the capillary electrophoresis module. The viscosity detection and control module includes a detection unit for detecting the viscosity of the sample solution to be tested and a control unit for adding viscosity modifiers to control the viscosity of the sample solution to be tested; The control unit is connected to the detection unit. The detection unit collects and analyzes the viscosity data of the sample solution in real time. When the viscosity data is higher than the preset target viscosity threshold range, a viscosity-increasing control signal is generated. When the viscosity data is lower than the preset target viscosity threshold range, a viscosity-decreasing control signal is generated. When the viscosity data is within the target viscosity threshold range, a stop signal is generated.

[0007] The technical principle of the above scheme is as follows: This scheme is based on a conventional gene analyzer, and a viscosity detection and control module is added before the automatic sample introduction module to realize real-time viscosity data acquisition during sample solution transportation. The viscosity data is compared with the preset target viscosity threshold range. Based on the comparison results, the viscosity-increasing or viscosity-decreasing regulator is automatically added through the design control unit to adjust the viscosity of the sample solution to the target threshold range. Subsequently, the sample solution with the qualified viscosity is loaded into the capillary electrophoresis module through the automatic sample introduction module. After electrophoretic separation, the laser detection module completes the detection and analysis.

[0008] The above approach has the following beneficial effects: 1. This solution addresses the impact of excessively high or low sample solution viscosity on capillary electrophoresis separation technology by coordinating the detection and control units, thereby improving experimental repeatability and the accuracy of separation results.

[0009] 2. This solution ensures the stability of the capillary electrophoresis separation process, provides a reliable sample basis for gene information analysis, and improves the accuracy of the final analysis results.

[0010] Furthermore, the autosampler module includes a microplate and a sealing gasket. The sealing gasket is attached to the bottom of the microplate, and the capillary electrophoresis module can puncture the sealing gasket to allow the sample solution to be tested to enter the capillary electrophoresis module.

[0011] Beneficial effects: The combination design of microplate and sealing gasket prevents sample leakage or contamination by sealing gasket, while ensuring effective contact between capillary and sample, thus improving the accuracy and reliability of sample injection.

[0012] Furthermore, the detection unit includes a first transport tube, a rotational viscometer, and a processor. The rotational viscometer is installed inside the first transport tube and is signal-connected to the processor.

[0013] Beneficial effects: The sample is transported through the first transport tube, and the rotational viscometer detects the sample viscosity in real time and transmits the data to the processor for analysis; this enables online real-time detection of sample viscosity, providing accurate data support for subsequent viscosity control and ensuring the timeliness and accuracy of the detection.

[0014] Furthermore, the control unit includes a liquid filling connector, which includes a liquid receiving inlet and a mixed liquid outlet. The liquid receiving inlet is connected to the first transport pipe. The liquid receiving inlet is also equipped with a liquid filling component, which is used to receive signals from the processor to control the timing of the filling of viscosity modifier into the liquid receiving inlet. The outlet of the mixed liquid is connected to a second transport pipe, which is connected to a microporous plate.

[0015] Beneficial effects: The sample and the regulator added by the liquid addition component are received from the first transport tube through the liquid inlet. The mixed sample is transported to the microplate through the mixing outlet and the second transport tube. The liquid addition component adjusts the timing of regulator filling according to the processor signal to achieve precise addition of regulator and uniform mixing of sample, ensuring effective viscosity control and smooth delivery of sample to the automatic sample injection module.

[0016] Furthermore, viscosity modifiers include thickening modifiers and thinning modifiers.

[0017] Beneficial effects: Viscosity modifiers include two types: viscosity increasers and viscosity decreasers, which can be adjusted bidirectionally according to the sample viscosity; this enables flexible processing of samples with different viscosities, expands the applicability of the device, and ensures comprehensive viscosity control.

[0018] Furthermore, the liquid filling assembly includes a viscosity-enhancing liquid filling tube, one end of which is connected to a liquid inlet, and the other end of which is connected to a first electrically controlled liquid valve. The first electrically controlled liquid valve is signal-connected to a controller, which is signal-connected to a processor. The other end of the first electrically controlled liquid valve is connected to a first storage tank, and the viscosity-enhancing agent is filled into the first storage tank. The liquid filling assembly also includes a viscosity-reducing liquid filling tube. One end of the viscosity-reducing liquid filling tube is connected to the liquid inlet, and the end of the viscosity-reducing liquid filling tube away from the liquid inlet is connected to a second electrically controlled liquid valve. The second electrically controlled liquid valve is connected to the controller signal. The end of the first electrically controlled liquid valve away from the viscosity-increasing liquid filling tube is connected to a second storage tank, and the viscosity-reducing regulator is filled into the second storage tank.

[0019] Beneficial effects: The addition of both viscosity modifiers and viscosity reducers is controlled by signals from the first and second electro-hydraulic valves. The controller receives signals from the processor to control the opening and closing of any electro-hydraulic valve, achieving automatic and precise addition of viscosity modifiers / viscosity reducers. The amount of viscosity modifier added is adjusted according to the real-time viscosity of the sample, improving the efficiency and accuracy of viscosity control.

[0020] Furthermore, the viscosity-increasing agent is a polyethylene glycol solution, and the viscosity-reducing agent is a TE buffer solution.

[0021] Beneficial effects: By using polyethylene glycol solution as a viscosity modifier and TE buffer as a viscosity depressant, the properties of both can be utilized to adjust the sample viscosity; this not only ensures the viscosity control effect but also has little impact on the sample's biological activity, thus guaranteeing the accuracy of subsequent gene analysis results.

[0022] Furthermore, the second transport pipe is a spiral-shaped pipe.

[0023] Beneficial effects: The spiral structure of the second delivery tube extends the mixing path of the sample and the regulator and enhances shear force and turbulent disturbance; it improves the mixing uniformity of the sample and the regulator, breaks down the aggregation of macromolecules in high-viscosity solutions, and optimizes the viscosity control effect.

[0024] Furthermore, several diversion plates are fixedly connected inside the second transport pipe.

[0025] Beneficial effects: The design of the diversion plate divides the liquid flow to enhance local turbulence and shearing, improves the mixing effect of the sample and the regulator, increases the probability of breaking up large molecular aggregates, and improves the mixing uniformity.

[0026] Furthermore, the diameter of the first transport pipe is smaller than the diameter of the second transport pipe.

[0027] Beneficial effects: This design creates localized turbulence due to the change in flow rate when the sample solution and viscosity modifier enter the second transport tube, promoting uniform mixing and improving the effectiveness of viscosity control.

[0028] Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0029] Figure 1 This is a schematic diagram of the overall structure of an embodiment of the bioinformatics acquisition and analysis device of the present invention; Figure 2 This is an isometric sectional view of the supporting shell in an embodiment of the bioinformation acquisition and analysis device of the present invention; Figure 3This is a schematic diagram showing the connection between the first transport tube and the second delivery tube in an embodiment of the bioinformation acquisition and analysis device of the present invention, as well as a cross-sectional view of the second transport tube. Figure 4 This is an isometric view of the microplate in an embodiment of the bioinformatics acquisition and analysis device of the present invention.

[0030] The reference numerals in the accompanying drawings of the instruction manual include: 1. Support housing; 2. Capillary electrophoresis module; 3. Automatic sample injection module; 301. Microplate; 302. Sealing gasket; 4. First transport tube; 5. Rotational viscometer; 6. Sample inlet; 7. Liquid filling connector; 701. Liquid receiving inlet; 702. Mixing outlet; 8. Second transport tube; 9. Viscosity-enhancing liquid filling tube; 10. First electro-hydraulic valve; 11. First storage tank; 12. Viscosity-reducing liquid filling tube; 13. Second electro-hydraulic valve; 14. Second storage tank; 15. Drainage plate. Detailed Implementation

[0031] The technical solution of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0032] In the description of this invention, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing the invention and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0033] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0034] The following detailed description illustrates the specific implementation method: Example 1:

[0035] This embodiment provides a bioinformatics acquisition and analysis device, which is integrated into an existing analyzer for description (for ease of description, the housing used to support the internal components of the analyzer referenced in this embodiment is referred to as the housing 1), specifically as follows: Figure 1 and Figure 2 As shown, the analytical device includes an automatic gel dispensing module and a capillary electrophoresis module 2. The end of the capillary electrophoresis module 2 is equipped with a laser detection module. Both the automatic gel dispensing module and the capillary electrophoresis module 2 are designed with reference to the automatic gel dispensing device and the four electrophoresis capillary components and supporting equipment in the existing ABI gene analyzer 3130.

[0036] In this embodiment, an automatic sample loading module 3 is provided at the end of the capillary electrophoresis module 2 furthest from the laser detection module. This module receives the sample solution to be tested and loads it into the capillary electrophoresis module 2. Specifically, in conjunction with... Figure 2 and Figure 4 As shown, the automatic sample introduction module 3 includes a microplate 301 (the microplate 301 is designed with reference to a 96-well microplate) and a sealing gasket 302. The sealing gasket 302 is attached to the bottom of the microplate 301. The capillary electrophoresis module 2 can puncture the sealing gasket 302 to guide the sample solution to be tested into the capillary electrophoresis module 2. The position of each capillary in the capillary electrophoresis module 2 needs to be strictly aligned with each well on the microplate 301.

[0037] When existing capillary electrophoresis (CE) separation technology is applied to gene detection and analysis, the separation relies on electroosmotic flow (EOF) within the capillary. When the viscosity of the sample solution is too low, it cannot effectively suppress the Joule heating generated during electrophoresis, leading to an increase in buffer temperature and subsequent drastic fluctuations in EOF. This results in significant fluctuations in the electrophoretic migration rate of DNA fragments, significant peak shifts, and reduced experimental repeatability. Conversely, when the sample solution viscosity is too high, the EOF rate significantly decreases, the separation time is greatly prolonged, and excessively high viscosity easily leads to uneven distribution of fluid flow resistance, causing disordered EOF distribution and further deteriorating the stability of the separation results. Therefore, to ensure the stability of the CE separation process, the viscosity of the sample solution loaded into the capillary needs to be precisely controlled. The special feature of this embodiment is that it specifically combines... Figure 2 and Figure 3 As shown: The automatic sample introduction module 3, located away from the capillary electrophoresis module 2, has a viscosity detection and control module at one end. This module includes a detection unit for detecting the viscosity of the sample solution and a control unit for adding viscosity modifiers to adjust the viscosity of the sample solution. The viscosity modifiers include thickening and thinning agents. Specifically: First, the detection unit includes a first transport tube 4, a rotational viscometer 5, and a processor. A sample inlet 6 is located at the top of the housing 1. One end of the first transport tube 4 is connected to the sample inlet 6. The first transport tube 4 is embedded within the housing 1. The rotational viscometer 5 (preferably a HYND-50 series online rotational viscometer 5) is installed inside the first transport tube 4. The rotational viscometer 5 is signal-connected to the processor. The processor receives the torque signal corresponding to the fluid resistance experienced by the rotational viscometer 5 at its sampling end (the rotor detection point of the rotational viscometer 5) during rotation. Based on a preset calibration model (designed with reference to the power-law model based on the core principle of Couette fluid dynamics of the rotational viscometer 5 in the prior art, combined with a calibration curve interpolation algorithm), the processor converts this torque signal into viscosity data of the sample solution flowing in real-time within the first transport tube 4. Then, the real-time viscosity data is compared with a preset target viscosity threshold. The specific data processing procedure is as follows: After the processor calculates the real-time viscosity data, it compares the real-time viscosity data with a preset target viscosity threshold range (the target viscosity threshold range is based on capillary electrophoresis (CE) systems such as PA800Plus / QIAxcel as a standard reference, preferably the generally accepted viscosity range of 0.2-5 cP). If the real-time viscosity data is lower than 0.2 cP, a viscosity-increasing control signal is generated; if the real-time viscosity data is higher than 5 cP, a viscosity-decreasing control signal is generated; if the real-time viscosity data is between 0.2 cP and 5 cP, a stop signal is generated.

[0038] Secondly, the control unit includes a liquid filling connector 7, which includes a liquid inlet 701 and a mixed liquid outlet 702. The liquid inlet 701 is connected to the first transport pipe 4 and is also equipped with a liquid filling component. The mixed liquid outlet 702 is connected to a second transport pipe 8, which is connected to the microporous plate 301. Specifically: Regarding the operation of increasing the viscosity of the sample solution: The liquid addition assembly includes a viscosity-enhancing liquid addition tube 9, one end of which is connected to the liquid inlet 701. The end of the viscosity-enhancing liquid addition tube 9 away from the liquid inlet 701 is connected to a first electrically controlled liquid valve 10. The first electrically controlled liquid valve 10 is signal-connected to a controller, which is signal-connected to a processor. The end of the first electrically controlled liquid valve 10 away from the viscosity-enhancing liquid addition tube 9 is connected to a first storage tank 11. The viscosity-enhancing agent (polyethylene glycol solution) is filled into the first storage tank 11. After receiving the viscosity-enhancing control signal sent by the processor, the controller generates a control electrical signal to drive the first electrically controlled liquid valve 10 to open and connect the first storage tank 11 with the liquid inlet 701. During the process, the processor continuously compares the real-time viscosity with the target viscosity threshold range. When the real-time viscosity data drops to the target viscosity threshold range, the processor generates a stop signal. The stop signal is received by the controller and drives the first electrically controlled liquid valve 10 to block the connection between the storage tank and the liquid inlet 701.

[0039] Regarding the operation of reducing the viscosity of the sample solution: The liquid addition assembly also includes a viscosity-reducing liquid addition tube 12. One end of the viscosity-reducing liquid addition tube 12 is connected to the liquid inlet 701, and the end of the viscosity-reducing liquid addition tube 12 away from the liquid inlet 701 is connected to a second electrically controlled liquid valve 13. The second electrically controlled liquid valve 13 is connected to the controller signal. The end of the first electrically controlled liquid valve 10 away from the viscosity-increasing liquid addition tube 9 is connected to a second storage tank 14. The viscosity-reducing regulator is filled in the second storage tank 14 (the viscosity-reducing regulator is TE buffer). After the controller receives the viscosity-reducing control signal sent by the processor, it generates a control electrical signal to drive the second electrically controlled liquid valve 13 to open to connect the second storage tank 14 and the liquid inlet 701. During the process, the processor continuously compares the real-time viscosity with the target viscosity threshold range. When the real-time viscosity data rises to the target viscosity threshold range, the processor generates a stop signal. The stop signal is received by the controller and drives the second electrically controlled liquid valve 13 to block the connection between the storage tank and the liquid inlet 701.

[0040] In addition, this embodiment precisely controls the viscosity of the sample solution loaded into the capillary tube. The design is as follows: (1) A suitable viscosity can effectively inhibit the longitudinal diffusion of DNA fragments, improve the resolution of electrophoretic separation, and enable nucleic acid fragments of similar length (such as short tandem repeat sequences or point mutation-related fragments) to form clear and distinguishable independent peaks, providing more reliable technical support for high-precision gene analysis scenarios such as gene typing and mutation detection; (2) A stable viscosity environment ensures the accuracy and consistency of pressure injection volume, avoiding problems such as insufficient injection (weak signal) due to excessively high viscosity or peak overload and tailing due to excessively low viscosity. This not only improves the accuracy of peak area and peak height quantitative data, but also reduces repeated experiments caused by injection errors, and reduces reagent consumption and experimental cycle.

[0041] Example 2:

[0042] The difference between this embodiment and Embodiment 1 lies in the specific combination... Figure 2 and Figure 3 As shown, in order to improve the mixing rate of the viscosity reducer and the test sample solution (to break down large molecular aggregates in high-viscosity solutions), this embodiment designs the second transport tube 8 as a spiral-shaped pipe. The spiral structure of the second transport tube 8, through an extended and continuously curved flow path of the mixed liquid (viscosity reducer and test sample solution), generates stronger shear forces and turbulent disturbances during transport, effectively breaking down large molecular aggregates in the high-viscosity solution. Furthermore, several guide plates 15 are integrally formed inside the second transport tube 8; the design of the guide plates 15 further divides the mixed liquid flow, enhances local turbulence and shearing effects, improves the mixing uniformity of the viscosity reducer and the test sample solution, and more thoroughly breaks down large molecular aggregates in the high-viscosity solution.

[0043] The diameter of the first transport tube 4 is smaller than that of the second transport tube 8, which allows the sample solution to obtain a higher flow rate before entering the spiral second transport tube 8. After entering, the sudden change in tube diameter creates local turbulence, which further enhances the mixing effect between the sample solution and the viscosity reducer, and more effectively disperses the large molecular aggregates in the high viscosity solution.

[0044] Obviously, the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the scope of protection of this invention.

Claims

1. A bioinformatics acquisition and analysis device, comprising an automatic gel dispensing module and a capillary electrophoresis module (2), wherein a laser detection module is provided at the end of the capillary electrophoresis module (2), characterized in that, The capillary electrophoresis module (2) is provided with an automatic sample injection module (3) at one end away from the laser detection module for receiving the sample solution to be tested and loading it into the capillary electrophoresis module (2). The automatic sample injection module (3) is provided with a viscosity detection and control module at one end away from the capillary electrophoresis module (2). The viscosity detection and control module includes a detection unit for detecting the viscosity of the sample solution to be tested and a control unit for adding viscosity modifiers to control the viscosity of the sample solution to be tested; The control unit is connected to the detection unit. The detection unit collects and analyzes the viscosity data of the sample solution in real time. When the viscosity data is higher than the preset target viscosity threshold range, a viscosity-increasing control signal is generated. When the viscosity data is lower than the preset target viscosity threshold range, a viscosity-decreasing control signal is generated. When the viscosity data is within the target viscosity threshold range, a stop signal is generated.

2. The bioinformation acquisition and analysis device according to claim 1, characterized in that, The automatic sample introduction module (3) includes a microplate (301) and a sealing gasket (302). The sealing gasket (302) is attached to the bottom of the microplate (301). The capillary electrophoresis module (2) can puncture the sealing gasket (302) to drain the sample solution to be tested into the capillary electrophoresis module (2).

3. The bioinformation acquisition and analysis device according to claim 2, characterized in that, The detection unit includes a first transport tube (4), a rotational viscometer (5), and a processor. The rotational viscometer (5) is installed inside the first transport tube (4) and is connected to the processor via signal.

4. The bioinformation acquisition and analysis device according to claim 3, characterized in that, The control unit includes a liquid filling connector (7), which includes a liquid inlet (701) and a mixed liquid outlet (702). The liquid inlet (701) is connected to the first transport pipe (4). The liquid inlet (701) is also provided with a liquid filling component, which is used to receive signals from the processor to control the timing of the filling of viscosity modifier into the liquid inlet (701). The mixed liquid outlet (702) is connected to a second transport pipe (8), which is connected to a microporous plate (301).

5. The bioinformation acquisition and analysis device according to claim 4, characterized in that, Viscosity modifiers include thickening modifiers and thinning modifiers.

6. The bioinformation acquisition and analysis device according to claim 5, characterized in that, The liquid filling assembly includes a viscosity-enhancing liquid filling tube (9), one end of which is connected to a liquid inlet (701), and the other end of the viscosity-enhancing liquid filling tube (9) away from the liquid inlet (701) is connected to a first electrically controlled liquid valve (10). The first electrically controlled liquid valve (10) is signal-connected to a controller, which is signal-connected to a processor. The other end of the first electrically controlled liquid valve (10) away from the viscosity-enhancing liquid filling tube (9) is connected to a first storage tank (11), and the viscosity-enhancing agent is filled into the first storage tank (11). The liquid filling assembly also includes a viscosity-reducing liquid filling pipe (12), one end of which is connected to the liquid inlet (701), and the other end of which is connected to a second electrically controlled liquid valve (13) away from the liquid inlet (701). The second electrically controlled liquid valve (13) is connected to the controller signal, and the other end of the first electrically controlled liquid valve (10) away from the viscosity-enhancing liquid filling pipe (9) is connected to a second storage tank (14). The viscosity-reducing regulator is filled into the second storage tank (14).

7. The bioinformation acquisition and analysis device according to claim 6, characterized in that, The viscosity modifier is a polyethylene glycol solution, and the viscosity reducing modifier is a TE buffer solution.

8. The bioinformation acquisition and analysis device according to claim 7, characterized in that, The second transport pipe (8) is a spiral-shaped pipe.

9. The bioinformation acquisition and analysis device according to claim 8, characterized in that, Several diversion plates (15) are fixedly connected inside the second transport pipe (8).

10. The bioinformation acquisition and analysis device according to claim 9, characterized in that, The diameter of the first transport pipe (4) is smaller than the diameter of the second transport pipe (8).

Images