Formula milk powder capable of being used for improving individual living quality and application of formula milk powder

Abstract

The invention provides formula milk powder capable of being used for improving individual life quality and application of the formula milk powder, the formula milk powder contains breast milk oligosaccharide, alpha-lactalbumin, beta-casein, lactoferrin and a composition of 1, 3-dioleic acid-2-palmitic acid triglyceride, and the breast milk oligosaccharide, the alpha-lactalbumin, the beta-casein, the lactoferrin and the 1, 3-dioleic acid-2-palmitic acid triglyceride are combined to form the formula milk powder. The weight ratio of the 1, 3-dioleic acid-2-palmitic acid triglyceride to the 1, 3-dioleic acid-2-palmitic acid triglyceride is (2.5-18): (10-55): (10-40): (1-8.5): (10- Wherein the breast milk oligosaccharide comprises 2 '-fucosyllactose and lactose-N-neotetraose, and the breast milk oligosaccharide, alpha-lactalbumin, beta-casein, lactoferrin and 1, 3-dioleic acid-2-palmitic acid triglyceride are added into the milk powder, so that the living quality of babies can be improved.

Description

Technical Field

[0001] This invention relates to the field of dairy technology, specifically to a formula milk powder that can be used to improve an individual's quality of life and its application. Background Technology

[0002] During the critical period of infant and toddler development (especially 0-1 years), the core of quality of life is reflected in three dimensions: "less discomfort, better absorption, and stable condition." At this stage, infants' digestive systems are immature, and their immune systems are not yet fully developed, making them prone to digestive problems (such as constipation and bloating), low nutrient absorption efficiency, and sensitivity to external stimuli (such as frequent crying and restless sleep). These issues not only directly affect the infant's physical comfort but may also indirectly affect their growth and development rhythm and emotional state, thereby reducing their overall quality of life. Breast milk, as the ideal food for infants, contains not only basic nutrients but also a variety of active ingredients that can precisely address these developmental challenges. Therefore, when exclusive breastfeeding is not possible or breast milk is insufficient, adding key active ingredients from breast milk to formula becomes an important way to help infants obtain nutritional support close to that of breast milk and improve their quality of life. Summary of the Invention

[0003] One object of the present invention is to provide a formula milk powder that can be used to improve an individual's quality of life.

[0004] Another object of the present invention is to provide the application of the above-mentioned formula milk powder in the preparation of products that improve individual quality of life.

[0005] Specifically, on the one hand, the present invention provides a formula milk powder that can be used to improve the quality of life of an individual, which contains a composition of human milk oligosaccharides, α-lactalbumin, β-casein, lactoferrin and 1,3-dioleoyl-2-palmitoylglycerol, wherein the weight ratio of the human milk oligosaccharides, α-lactalbumin, β-casein, lactoferrin and 1,3-dioleoyl-2-palmitoylglycerol is (2.5-18):(10-55):(10-40):(1-8.5):(10-96); wherein the human milk oligosaccharides include 2'-fucosylated lactose and lactose-N-neotetrasaccharide.

[0006] According to a specific embodiment of the present invention, the weight ratio of 2'-fucosylated lactose to lactose-N-neotetrasaccharide is (2-13):(0.5-5).

[0007] According to a specific embodiment of the present invention, the formula milk powder includes infant formula milk powder, toddler formula milk powder, or children's formula milk powder, preferably infant formula milk powder.

[0008] According to a specific embodiment of the present invention, the α-lactalbumin is derived from raw milk, skim milk powder, demineralized whey powder, whey protein powder, or other raw materials that can provide α-lactalbumin.

[0009] According to a specific embodiment of the present invention, the 1,3-dioleoyl-2-palmitoylglycerol is derived from coconut oil, anhydrous butter, or other raw materials that provide 1,3-dioleoyl-2-palmitoylglycerol.

[0010] According to a specific embodiment of the present invention, the β-casein is derived from raw milk, skim milk powder, demineralized whey powder, whey protein powder, or other raw materials that can provide β-casein.

[0011] According to a specific embodiment of the present invention, the lactoferrin is derived from raw milk, skim milk powder, whey protein powder, or other raw materials that provide lactoferrin.

[0012] According to a specific embodiment of the present invention, each 100g of formula milk powder contains: 200-1300mg of 2'-fucosylated lactose, 50-500mg of lactose-N-neotetrasaccharide, 1000-5500mg of α-lactalbumin, 1000-4000mg of β-casein, 100-850mg of lactoferrin, and 1000-9600mg of 1,3-dioleoyl-2-palmitoylglycerol.

[0013] According to a specific embodiment of the present invention, the raw material composition of every 1000 servings of formula milk powder includes: 800-2000 parts by weight of raw milk; Lactose 10-350 parts by weight; Skim milk powder 0-325 parts by weight; Demineralized whey powder 0-450 parts by weight; Whey protein powder 0-170 parts by weight; Sunflower seed oil 1-80 parts by weight; Corn oil 0-40 parts by weight; Soybean oil 0-80 parts by weight; Coconut oil 0-30 parts by weight; Low-erucic acid rapeseed oil, 0-85 parts by weight; 0-20 parts by weight of flaxseed oil; 0-96 parts by weight of 1,3-dioleoyl-2-palmitoylglycerol triglyceride; Soybean lecithin 0.5-5 parts by weight; 0-2 parts by weight of anhydrous butter; 0-40 parts by weight of fructooligosaccharide powder; 0-100 parts by weight of galactooligosaccharide syrup; A complex of nutrients containing calcium powder, vitamins and minerals, 7-25 servings by weight; DHA 0-20 parts by weight; ARA 0-25 parts by weight; Bifidobacterium 0-2.5 parts by weight; 0-1 parts by weight of nucleotides; Lactoferrin powder 0-8.5 parts by weight; α-lactalbumin powder 0-55 parts by weight; 0-40 parts by weight of β-casein powder; Lactose-N-neotetrasaccharide raw material: 0.5-5 parts by weight; 2-13 parts by weight of 2'-fucosylated lactose raw material.

[0014] In the formula milk powder of this invention, all raw materials are commercially available, and the selection of each raw material should meet the relevant standard requirements. The specific amount of each raw material should be appropriately adjusted under the premise of meeting the product index requirements, so as to meet the content requirements of human milk oligosaccharides, α-lactalbumin, β-casein, lactoferrin and 1,3-dioleoyl-2-palmitoylglycerol in the product.

[0015] In the formula milk powder of this invention, product performance indicators not detailed or listed shall be implemented in accordance with the relevant national standards (such as national standards for infant or children's formula food) and related standards and regulations.

[0016] On the other hand, the present invention also provides the application of the above-mentioned formula milk powder in the preparation of products that improve individual quality of life.

[0017] According to a specific embodiment of the present invention, the product for improving the quality of life of an individual is food; preferably, the individual is an infant; preferably, the food includes nutritional supplements, liquid milk, non-infant milk powder, infant formula powder or infant complementary food.

[0018] According to a specific embodiment of the present invention, the improvement of individual quality of life includes one or more of the following: improved sleep, improved feeding, improved breathing, improved bowel movements, improved mood, improved skin condition, and improved interaction.

[0019] In this invention, the non-infant can be a child or an adult.

[0020] The present invention has the following beneficial technical effects: This invention provides an infant formula milk powder with added human milk oligosaccharides (HMOs), α-lactalbumin, β-casein, lactoferrin, and OPO, which can improve the quality of life of infants. Human milk oligosaccharides (HMOs), α-lactalbumin, β-casein, lactoferrin, and OPO structured lipids have been proven to be key components in breast milk that play a crucial role in infants' digestive comfort, immune protection, and nutrient utilization. They do not act alone, but rather work synergistically to create a comfortable growth environment for infants from multiple dimensions, ultimately improving their quality of life. Attached Figure Description

[0021] Figure 1 This is for IQI total score statistics.

[0022] Figures 2-4 This represents the percentage of infants with normal IQI scores. Detailed Implementation

[0023] In order to provide a clearer understanding of the technical features, objectives and beneficial effects of the present invention, the technical solution of the present invention will now be described in detail below, but it should not be construed as limiting the scope of implementation of the present invention.

[0024] Example: This study investigated the effects of infant formula containing human milk oligosaccharides (HMOs), OPO, lactoferrin, α-lactalbumin, and β-casein on the quality of life of infants. The study included an experimental group, a control group, and a breast milk group. A total of 300 infants aged 14 days or younger were recruited, of whom 255 completed the intervention. Infants were divided into three groups based on the formula they were fed: the experimental group (NTotal=84) containing HMOs, OPO, lactoferrin, α-lactalbumin, and β-casein; the control group (NTotal=90) not containing HMOs, α-lactalbumin, β-casein, lactoferrin, and OPO; and the breast milk group (NTotal=81). Quality of life questionnaires were collected from parents at baseline, 6 weeks of age, 3 months of age, 4 months of age, and 6 months of age. The specific ingredients of the formulas for the experimental and control groups are shown in Tables 1-2 (Table 2 is a continuation of Table 1). Table 1

[0025] Table 2

[0026] Data Results: The quality of life of infants in each group was assessed using the Infant Quality of Life Questionnaire (IQI) reported by parents.

[0027] The Infant Quality of Life Questionnaire (IQI) is a universal tool for assessing the overall health and quality of life of infants under one year old. It includes seven aspects: sleep, feeding, breathing, bowel movements / defecation, mood, skin, and interaction, and is completed by the infant's parents. Each question has four options, numbered 0, 1, 2, and 3 from top to bottom. The lower the total score, the higher the quality of life. The total IQI score is shown in Table 3. The IQI total score is calculated as follows: Figure 1 As shown.

[0028] Table 3 This indicates a significant difference compared to the experimental group (p < 0.05).

[0029] At baseline, the total IQI scores reported by parents were 1.86±1.43 in the experimental group, 1.70±1.30 in the control group, and 2.11±1.54 in the breastfed group, showing comparability among the three groups. Significant differences in total IQI scores were observed between the experimental and control groups at 6 weeks, 3 months, 4 months, and 6 months of age, with the control group showing significantly higher scores. There were no significant differences in total IQI scores between the experimental and breastfed groups at these ages. The IQI scores indicate that infants in the experimental group had a better quality of life compared to the control group, suggesting that feeding infants with added human milk oligosaccharides, α-lactalbumin, β-casein, lactoferrin, and OPO can significantly improve their quality of life.

[0030] The specific circumstances of the infants were analyzed based on the details of each score in the IQI questionnaire, categorized into normal and affected groups. The results of the Infant Quality of Life Questionnaire (IQI questionnaire) are summarized in Tables 4-7 (Tables 5-7 are continuations of Table 4). The proportion of normal infants in each IQI score is as follows: Figures 2-4 As shown.

[0031] Table 4

[0032] Table 5

[0033] Table 6

[0034] Table 7 This indicates a significant difference compared to the experimental group (p < 0.05).

[0035] The IQI scores for each item showed no significant differences at baseline among the three groups of infants, indicating they were comparable. The number of normal-behaved infants in the experimental group was higher than that in the control group during visits, but there was no significant difference compared to the breastfed group. The experimental group showed particularly better performance in areas such as sleep, bowel movements, and feeding, with significantly higher numbers of normal-behaved babies at 6 weeks, 3 months, 4 months, and 6 months of age compared to the control group.

[0036] Clinical trials have shown that infant formula milk powder with added human milk oligosaccharides, α-lactalbumin, β-casein, lactoferrin, and OPO can improve the quality of life of infants.

Claims

1. A formula milk powder that can be used to improve an individual's quality of life, comprising a composition of human milk oligosaccharides, α-lactalbumin, β-casein, lactoferrin, and 1,3-dioleoyl-2-palmitoylglycerol triglyceride, wherein, The weight ratio of the human milk oligosaccharide, α-lactalbumin, β-casein, lactoferrin and 1,3-dioleoyl-2-palmitoylglycerol triglyceride is (2.5-18):(10-55):(10-40):(1-8.5):(10-96); wherein the human milk oligosaccharide includes 2'-fucosylated lactose and lactose-N-neotetrasaccharide.

2. The formula milk powder according to claim 1, wherein, The weight ratio of 2'-fucosylated lactose to lactose-N-neotetrasaccharide is (2-13):(0.5-5).

3. The formula milk powder according to claim 1 or 2, wherein, The formula milk powder includes infant formula milk powder, toddler formula milk powder, or children's formula milk powder, preferably infant formula milk powder.

4. The formula milk powder according to claim 1, wherein, The α-lactalbumin is derived from raw milk, skim milk powder, demineralized whey powder, whey protein powder, or other raw materials that can provide α-lactalbumin.

5. The formula milk powder according to claim 1, wherein, The β-casein is derived from raw milk, skim milk powder, demineralized whey powder, whey protein powder, or other raw materials that provide β-casein.

6. The formula milk powder according to claim 1, wherein, The lactoferrin is derived from raw milk, skim milk powder, whey protein powder, or other raw materials that provide lactoferrin.

7. The formula milk powder according to any one of claims 1-6, wherein each 100g of formula milk powder contains: 200-1300mg of 2'-fucosylated lactose, 50-500mg of lactose-N-neotetrasaccharide, 1000-5500mg of α-lactalbumin, 1000-4000mg of β-casein, 100-850mg of lactoferrin, and 1000-9600mg of 1,3-dioleoyl-2-palmitoylglycerol.

8. The use of the formula milk powder according to any one of claims 1-7 in the preparation of products that improve individual quality of life.

9. The application according to claim 8, wherein, The product that improves the quality of life of an individual is food; preferably, the individual is an infant or young child; preferably, the food includes nutritional supplements, liquid milk, non-infant milk powder, infant formula, or complementary food for infants and young children.

10. The application according to claim 9, wherein, The improvement of an individual's quality of life includes one or more of the following: improved sleep, improved feeding, improved breathing, improved bowel movements, improved mood, improved skin condition, and improved interaction.

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