Noninvasive self-suction blood detection device

Abstract

The invention discloses a non-invasive self-suction blood detection device, and relates to the technical field of medical instruments. The device comprises a bionic needle layer, a saliva bionic coating, a self-absorption blood core layer, a detection reaction layer and a result observation window. Micro-needles with nano sawtooth structures and internal micro-channels are densely distributed on the surface of the bionic needle layer; the saliva bionic coating contains anticoagulation and anesthesia components; the self-absorption blood core layer guides blood through capillary action; and the detection reaction layer is integrated with a biochemical reagent and is used for detecting indexes such as blood glucose, blood fat and blood uric acid. When in use, the device is attached to the skin and is slightly pressed, blood is automatically inhaled and flows to the detection layer after the micro needle is punctured, and a user can read a result through the observation window. Bionic design is fused, integration of minimally invasive, painless, self-blood-sucking and rapid detection is achieved, operation is easy and convenient, and the device is suitable for families and basic medical scenes.

Description

Technical Field

[0001] This invention relates to the field of medical devices and biomedical testing technology, specifically to a non-invasive self-absorption blood detection device. Background Technology

[0002] Traditional blood tests require venipuncture or finger-prick blood collection, which presents problems such as significant trauma, intense pain, increased risk of infection, large amounts of medical waste, and the need for professional operation. While existing minimally invasive blood glucose meters and other devices on the market are less invasive, they typically only measure a single indicator, and their blood collection mechanisms still cause significant pain nerve stimulation, with limited blood volume. Furthermore, current technologies often separate blood collection and testing into two separate steps, making the process cumbersome.

[0003] Mosquitoes, as highly efficient miniature blood-collecting devices, possess mouthparts with characteristics such as minimal invasiveness, analgesia, and anticoagulation. Their mechanisms of graded insertion, serrated cutting structure, saliva lubrication, and anesthesia provide an excellent biomimetic blueprint for designing next-generation minimally invasive blood collection devices. However, transforming this complex biological mechanism into a stable, controllable, and mass-producible engineered device, and achieving seamless integration with a detection module, remains a pressing technical challenge. Summary of the Invention

[0004] The purpose of this invention is to provide a non-invasive self-sucking test strip based on the biomimetic principle of mosquito blood-sucking, which simulates the cutting, spreading, anticoagulation and blood-sucking process of mosquito mouthparts, and realizes the integrated functions of minimally invasive, self-sucking and rapid detection.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a non-invasive self-absorption blood detection device, comprising: a biomimetic needle layer, the top of which is densely covered with microneedles, each of the microneedles having a nano-serrated structure on its outer wall and a microchannel inside; a saliva biomimetic coating, coated on the surface of the biomimetic needle layer, containing anticoagulant components; a self-absorption blood core layer, disposed at the bottom of the biomimetic needle layer, and having capillary action; a detection reaction layer, disposed at the bottom of the self-absorption blood core layer, and containing biochemical reagents for blood indicators; and a result observation window, opened at the bottom of the detection reaction layer.

[0006] Preferably, the material of the biomimetic needle layer is a medical polymer or a biodegradable material.

[0007] Preferably, the saliva-inspired coating also contains a mild local anesthetic component.

[0008] Preferably, the self-absorbing core layer is made of hydrophilic fiber or porous material.

[0009] Preferably, the detection reaction layer is used to detect at least one of blood glucose, blood lipids, and blood uric acid.

[0010] Preferably, it also includes a backing layer and a peelable protective film.

[0011] Preferably, a method using a non-invasive self-sucking blood detection device is characterized by comprising:

[0012] Apply the test strip to the skin and press gently to allow the bionic microneedles to penetrate.

[0013] Blood enters the self-absorbing core layer through microchannels and flows to the detection reaction layer under capillary action;

[0014] Read the test results through the results viewing window.

[0015] The beneficial effects of this invention are as follows:

[0016] Painless and minimally invasive: Through the biomimetic microneedle structure and the biomimetic saliva coating containing anesthetic ingredients, the pain of puncture is significantly reduced, achieving near-painless minimally invasive blood collection.

[0017] Integrated self-aspirating blood detection: It integrates biomimetic puncture, anticoagulation, self-aspirating blood and detection functions into one, eliminating the need for additional blood collection steps, simplifying the operation process and making it convenient for users to self-test.

[0018] Multi-index detection: The detection reaction layer can integrate a variety of biochemical reagents, supporting the simultaneous or selective detection of multiple blood indicators such as blood glucose, blood lipids, and blood uric acid.

[0019] Safety and hygiene: Made of medical or biodegradable materials, it is easy to dispose of after use, reducing medical waste; the protective membrane design ensures the device is sterile and reduces the risk of infection.

[0020] Biomimetic efficiency: The nano-serrated structure and microchannel design, which mimic the mouthparts of mosquitoes, improve penetration efficiency and blood collection volume, thereby enhancing detection reliability.

[0021] Widely applicable: Suitable for home self-testing, primary healthcare and remote health monitoring scenarios, no professional operators are required, improving the accessibility and convenience of testing.

[0022] In addition, it can measure local blood drug concentration, such as the local blood drug concentration after transdermal administration. Attached Figure Description

[0023] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0024] Figure 1 This is a schematic diagram of the overall structure of the present invention;

[0025] Figure 2 This is an enlarged view of a partial structure of the present invention.

[0026] In the figure: 1. Bionic needle layer; 2. Microneedle; 3. Serrated structure; 4. Microchannel; 5. Saliva bionic coating; 6. Self-absorbing blood core layer; 7. Detection reaction layer; 8. Result observation window; 9. Backing layer; 10. Protective film. Detailed Implementation

[0027] The technical solution of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0028] Example 1: Device Structure

[0029] like Figure 1 , Figure 2 As shown, the non-invasive self-absorption blood detection device of the present invention includes the following hierarchical structure:

[0030] Bionic needle layer 1: Made of medical-grade polymer materials, such as biodegradable materials like polylactic acid and polycaprolactone, or biocompatible polymers, with its surface densely covered with microneedles 2. These microneedles 2 are machined with nanoscale serrated structures 3 to mimic the cutting action of a mosquito's mouthparts. Microchannels 4, with a diameter of 5-50 micrometers, are located inside the microneedles 2 to guide blood flow. The length of the microneedles 2 is 0.5-2.0 millimeters, ensuring that they only penetrate the superficial layer of the skin.

[0031] Saliva-inspired coating 5: Uniformly coated on the surface of microneedles 2, with a coating thickness of 1-10 micrometers. The coating contains anticoagulant components, such as heparin and citrate, as well as mild local anesthetic components, such as lidocaine and benzocaine, to reduce pain and prevent blood clotting.

[0032] Self-absorbing core layer 6: Located below the bionic needle layer 1, it is made of hydrophilic fibers or porous materials and has strong capillary action, which can automatically draw in and guide blood flow.

[0033] Detection reaction layer 7: Connected to the self-absorbing blood core layer 6, it contains biochemical reagents targeting specific blood indicators, such as glucose oxidase, cholesterol esterase, and uricase, which can detect one or more indicators among blood glucose, blood lipids, and blood uric acid. The reagents are fixed on the porous substrate in a dry chemical form.

[0034] Results observation window 8: Located on the surface of the device, it is a transparent or semi-transparent area, which allows users to directly read the color changes or optical signals generated by the detection reaction layer 7.

[0035] Backing layer 9 and protective film 10: Backing layer 9 is made of flexible waterproof material, such as medical PE or PU film, to provide structural support; protective film 10 covers the surface of bionic needle layer 1 and can be peeled off before use to ensure sterility and prevent contamination.

[0036] Example 2: Preparation method

[0037] Fabrication of biomimetic needle layer 1: Microneedles 2 array are fabricated using medical polymer materials through micro-injection molding or 3D printing, and nano-serrated structures 3 are formed on the surface by plasma etching or laser processing. Microchannels 4 are achieved through molding or post-processing drilling.

[0038] Saliva-inspired coating 5: A hydrogel or polymer solution containing anticoagulant and local anesthetic components is sprayed or dipped onto the surface of the microneedle 2 and then dried under vacuum to form a uniform coating.

[0039] The self-absorbing core layer 6 is integrated with the detection reaction layer 7: hydrophilic fibers or porous materials are cut into a predetermined shape and aligned with the biomimetic needle layer 1; the detection reaction layer 7 deposits biochemical reagents on the porous material by screen printing or inkjet printing, and then fixes them after drying.

[0040] Device assembly: The bionic needle layer 1, the self-absorbing blood core layer 6, the detection reaction layer 7 and the backing layer 9 are pressed together in sequence, and a protective film 10 is covered on the surface. The whole device is packaged into a test strip with a size of 10mm×30mm×1mm.

[0041] Example 3: Usage Method

[0042] The method of using this device includes the following steps:

[0043] Preparation: Remove the test strip from the packaging, peel off the protective film 10, and expose the bionic needle layer 1.

[0044] Adhesion and Insertion: Apply the test strip to the skin and gently press the backing layer 9 to allow the microneedles 2 to penetrate the superficial layer of the skin. The nano-serrated structure 3 helps reduce insertion resistance, and the saliva-inspired coating 5 provides local anesthesia and anticoagulation.

[0045] Blood aspiration and detection: Blood is automatically drawn into the self-absorption core layer 6 through microchannels 4 and capillary action, and flows to the detection reaction layer 7. The blood undergoes reactions with biochemical reagents, such as enzymatic color development, which are usually completed within 1-3 minutes.

[0046] Result reading: Color changes can be read directly through the result observation window 8, for example, by comparing with a colorimetric card or by using a portable optical reader to obtain quantitative results.

[0047] Treatment: After use, the device can be disposed of as medical waste; if biodegradable materials are used, it can be environmentally degraded.

[0048] Example 4: Detection Example

[0049] Taking blood glucose testing as an example: the detection reaction layer 7 contains glucose oxidase, peroxidase, and a chromogenic agent. Glucose in the blood produces hydrogen peroxide under the action of the enzymes, which in turn oxidizes the chromogenic agent, producing a color change. Users can obtain the blood glucose concentration value by comparing it with the colorimetric card through the result observation window 8. The device can simultaneously integrate multiple reagent areas to achieve multi-index detection.

[0050] This device achieves minimally invasive insertion through a biomimetic needle layer 1, a saliva biomimetic coating layer 5 to reduce pain and prevent coagulation, a self-absorbing blood core layer 6 for automatic blood collection, and a detection reaction layer 7 for rapid analysis. Its integrated design simplifies operation, requires no professional personnel, reduces infection risks and medical waste, and is suitable for home self-testing or primary healthcare settings.

[0051] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in the present invention should be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. A non-invasive self-absorption blood detection device, characterized in that, include: The biomimetic needle layer (1) has microneedles (2) densely distributed on its top. Each microneedle (2) has a nano-serrated structure (3) on its outer wall and a microchannel (4) inside. A saliva-inspired coating (5) is applied to the surface of the bionic needle layer (1) and contains anticoagulant components; The self-absorbing core layer (6) is disposed at the bottom of the bionic needle layer (1) and has a capillary effect; The detection reaction layer (7) is located at the bottom of the self-absorbing core layer (6) and contains biochemical reagents for blood indicators; The result observation window (8) is located at the bottom of the detection reaction layer (7).

2. The non-invasive self-absorption blood detection device according to claim 1, characterized in that, The material of the biomimetic needle layer (1) is a medical polymer or a biodegradable material.

3. The non-invasive self-absorption blood detection device according to claim 1, characterized in that, The saliva-inspired coating (5) also contains a mild local anesthetic component.

4. The non-invasive self-absorption blood detection device according to claim 1, characterized in that, The self-absorbing core layer (6) is made of hydrophilic fiber or porous material.

5. The non-invasive self-absorption blood detection device according to claim 1, characterized in that, The detection reaction layer (7) is used to detect at least one of blood glucose, blood lipids, and blood uric acid.

6. The non-invasive self-absorption blood detection device according to claim 1, characterized in that, It also includes a backing layer (9) and a peelable protective film (10).

7. A method for using the non-invasive autologous blood aspiration detection device as described in any one of claims 1-6, characterized in that, include: Apply the test strip to the skin and press it gently so that the bionic microneedle (2) can penetrate it; Blood enters the self-absorbing core layer (6) through the microchannel (4) and flows to the detection reaction layer (7) under capillary action; Read the test results through the results observation window (8).

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