Whitening and anti-light damage skin repair composition and preparation method thereof

Abstract

The invention relates to the technical field of cosmetics, in particular to a skin repairing composition for whitening and resisting light damage and a preparation method. The composition comprises polypeptides such as acetyl tetrapeptide-11, glutathione, decarboxylated carnosine, tripeptide-1 and the like, the effects of whitening and brightening the skin, resisting light aging and repairing the skin are achieved through multi-way, multi-azimuth and multi-target combined action and mutual cooperation, and the effects of improving the skin quality and repairing the skin can be better achieved. The composition disclosed by the invention can be widely applied to various cosmetics.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, specifically to a skin repair composition for whitening and resisting photodamage, and its preparation method. Background Technology

[0002] Skin is an organ that protects, excretes waste, and senses external stimuli. It can be divided into two layers: the epidermis and the dermis. Nowadays, people are increasingly focused on skin care and repair, hoping to maintain a youthful appearance while keeping their mindset young. However, in reality, skin undergoes irreversible aging due to factors such as irregular sleep patterns, UV exposure, computer radiation, and aging, causing the skin to lose its suppleness, radiance, and elasticity.

[0003] Melanin has the greatest impact on skin color, and its formation pathway in the skin is as follows: Ultraviolet radiation induces keratinocytes in the epidermis to produce melanocyte-stimulating hormone precursor (POMC) / melanocyte-stimulating hormone (α-MSH) and interleukins. α-MSH is an endogenous neuropeptide that, after binding to melanocortin receptor-1 (MC1-R) on the surface of melanocytes, regulates melanin production. The process is as follows: after α-MSH binds to MC1-R, it activates adenylate cyclase, which in turn increases intracellular cAMP. The increased cAMP further activates protein kinase C (PKC), which ultimately activates tyrosine kinases in melanocytes. Under the action of tyrosine kinases, dopa and dopaquinone are produced, ultimately forming melanin. Melanin reaches the skin surface with the metabolism of keratinocytes, resulting in darker skin color or the appearance of spots.

[0004] Currently, there is a wide variety of whitening and anti-aging products on the market. However, the comprehensive issues of UV protection, whitening, anti-aging, and minimal skin irritation are not always well resolved, leading to a proliferation of products on the market.

[0005] Most skin-whitening products on the market are tyrosinase inhibitors, but the melanin production pathway is very complex, and the effect of lightening spots and whitening is not ideal. Many products are under development. For example, existing technology CN101631532A provides a skin-whitening combination, which includes at least: an MC1-R receptor inhibitor; a vitamin C-derived tyrosinase inhibitor; and an inhibitor of melanosome transfer to keratinocytes. This invention also relates to its application in cosmetics and dermatology for preparing a depigmenting composition that whitens and / or brightens the skin. CN101917961A provides a topical cosmetic composition, characterized in that it includes, in a cosmetic carrier: at least one agent that restricts the binding of α-MSH to the MC-1 receptor, at least one agent that restricts ET-1 synthesis, at least one agent that inhibits SCF synthesis, and at least one agent that inhibits tyrosine activity.

[0006] Bioactive peptides, as functional materials for anti-aging, have potential application value. They can promote and accelerate cell growth, proliferation, and the synthesis of proteins or polypeptides, playing an important role in alleviating skin aging and repairing skin damage. For example, palmitoyl peptides, acetyl peptides, and carnosine are recognized as highly effective and safe active ingredients for preventing and combating skin aging, widely used in the beauty and skincare field for purposes such as anti-aging, skin repair, and brightening skin tone. Because each active peptide has a unique structure and function, its mechanism of action and target points on the skin are relatively clear, resulting in significant efficacy. Therefore, it is necessary to combine peptides with different functions to achieve multifaceted and comprehensive anti-aging effects. However, there are also many shortcomings.

[0007] However, for peptide raw materials, the efficacy of a single ingredient is limited. Due to factors such as cost and economic efficiency, there are few peptide-based compositions in the skincare industry. Peptides are proteins, and their stability is affected by various factors. The presence of high temperatures, surfactants, microorganisms, preservatives, and oxygen can easily alter their protein structure and cause them to lose activity. This makes it difficult for them to penetrate deep into the skin, resulting in significantly reduced effectiveness. To meet market demand, there is an urgent need to develop a skin repair composition that whitens and protects against photodamage, enabling it to achieve anti-UV, whitening, and anti-aging effects in cosmetics. Summary of the Invention

[0008] The purpose of this invention is to overcome the shortcomings of the prior art and provide a skin repair composition for whitening and resisting photodamage. This composition can effectively reduce melanin production, thereby brightening skin tone, and has good firming, anti-wrinkle, whitening, and anti-photodamage effects.

[0009] Specifically, the present invention adopts the following technical solution: In a first aspect, the present invention provides a composition comprising the following components in weight percentages: 0.015-0.03% tripeptide-1, 0.03-0.05% acetyl tetrapeptide-11, 0.02-0.04% glutathione, 0.03-0.06% decarboxylated carnosine, 0.05-1.5% vitamin E polyethylene glycol succinate, 60-70% polyol, 1-5% solubilizer, and the balance being water.

[0010] Preferably, in one embodiment, the composition comprises the following components in weight percentages: 0.020-0.025% tripeptide-1, 0.03-0.04% acetyl tetrapeptide-11, 0.025-0.03% glutathione, 0.04-0.05% decarboxylated carnosine, 0.5-1.5% vitamin E polyethylene glycol succinate, 60-70% polyol, 3-5% solubilizer, and the balance being water.

[0011] Preferably, in one embodiment, the composition comprises the following components in weight percentages: 0.025% tripeptide-1, 0.04% acetyl tetrapeptide-11, 0.025% glutathione, 0.04% decarboxylated carnosine, 1.0% vitamin E polyethylene glycol succinate, 70% polyol, 4% solubilizer, and the balance being water.

[0012] Preferably, the polyol is selected from one or more of glycerol, butylene glycol, propylene glycol, and hexanediol. Glycerol is further preferred.

[0013] Preferably, the solubilizer is one or more of polysorbate-20, polysorbate-60, and polysorbate-80; more preferably, polysorbate-20.

[0014] The compositions of the present invention can be used directly as cosmetics, or as a base for preparing skin care products or medical products for external use.

[0015] The present invention relates to the application of the composition in the preparation of cosmetics. The main dosage forms developed for cosmetic products include serums, powders (capsules, lyophilized powders), emulsions, creams, gels, masks, dressings, etc.

[0016] The cosmetic essence of the above-mentioned composition is preferably applied directly.

[0017] In another aspect, the present invention provides a method for preparing a skin repair composition for whitening and resisting photodamage, specifically comprising the following steps: Step 1: Weigh out the prescribed amounts of polyol, solubilizer, tripeptide-1, and decarboxylated carnosine, dissolve them in an appropriate amount of water, and homogenize them; Step 2: Dissolve the prescribed amounts of acetyl tetrapeptide-11, glutathione, and vitamin E polyethylene glycol succinate in an appropriate amount of water to prepare a mixed solution; Step 3: Pour the solution from Step 1 into the mixture from Step 2, mix well, add water to the full volume, stir evenly, homogenize, and obtain the composition.

[0018] Specifically, the structural formulas of acetyl tetrapeptide-11, glutathione, decarboxycarnosine, and tripeptide-1 are well-known and clearly defined. Each peptide has broad application prospects and market potential in the cosmetics field. However, the stability, solubility, and permeability of each peptide compound vary greatly. Tripeptide-1 cannot be used with acidic substances (fruit acids, retinoic acid, high-concentration water-soluble L-ascorbic acid, salicylic acid, etc.); it cannot be combined with excessively acidic or alkaline finished products, and excessively low or high pH can lead to decomposition, inactivation, discoloration, and loss of function. In this invention, the addition of vitamin E polyethylene glycol succinate can effectively maintain the stability and activity of acetyl tetrapeptide-11, decarboxycarnosine, and tripeptide-1 in the same system. It also promotes the skin permeability of peptide substances and enhances their absorption. The addition of glutathione not only keeps the composition stable under photothermal conditions, but glutathione itself also has antioxidant, detoxifying, whitening, and spot-fading effects, and is widely used in cosmetics.

[0019] The beneficial effects of this invention are: The four peptides in the composition provided by this invention have clearly defined sources and targets, and their mechanisms are well-defined. They can function individually or work synergistically at multiple targets, protecting the skin at different levels and along the entire pathway to reduce the formation of fine lines, dynamic wrinkles, and static wrinkles, maximizing moisturizing, firming, and whitening effects. Simultaneously, the specific selection of polyols and solubilizers in the matrix composition further contributes to achieving excellent permeability, stability, and gentleness. Furthermore, no preservatives or pH adjustments are required in the matrix composition, making it non-irritating to human skin. Additionally, acetyl tetrapeptide-11 and decarboxylated carnosine counteract photodamage, enhance the production of photosensitive proteins (such as photolyases), neutralize UV-induced DNA damage (such as thymine dimers), and reduce the risk of photoaging. Together, they systematically protect DNA, increase cell metabolism, and restore cell vitality. Detailed Implementation

[0020] The present invention will be further illustrated by the following embodiments. It should be understood that the embodiments of the present invention are merely for illustrating the present invention and are not intended to limit the present invention. Therefore, any simple improvements to the present invention under the premise of the method of the present invention are within the scope of protection of the present invention.

[0021] Unless otherwise specified, the experimental methods used in the following examples are conventional methods; the materials and reagents used are commercially available unless otherwise specified.

[0022] Example 1, Formulation of the composition Component Name Content percentage Tripeptide-1 0.025％ Acetyl tetrapeptide-11 0.04％ Glutathione 0.025％ Decarboxylated carnosine 0.04％ Vitamin E polyethylene glycol succinate 1.0％ glycerin 70％ Polysorbate-20 4.0％ Deionized water margin The specific preparation method is as follows: Step 1: Weigh the prescribed amounts of glycerin, polysorbate-20, tripeptide-1, and decarboxylated carnosine, dissolve them in an appropriate amount of deionized water, and homogenize them; Step 2: Dissolve the prescribed amounts of acetyl tetrapeptide-11, glutathione, and vitamin E polyethylene glycol succinate in an appropriate amount of water to prepare a mixed solution; Step 3: Pour the solution from Step 1 into the mixture from Step 2, mix well, add water to the full volume, stir evenly, homogenize, and obtain the composition.

[0023] Example 2, Formulation of the composition Component Name Content percentage Tripeptide-1 0.015％ Acetyl tetrapeptide-11 0.03％ Glutathione 0.02％ Decarboxylated carnosine 0.03％ Vitamin E polyethylene glycol succinate 0.05％ glycerin 70％ Polysorbate-20 4.0％ Deionized water margin Specific preparation method: Same as in Example 1.

[0024] Example 3, Formulation of the composition Component Name Content percentage Tripeptide-1 0.03％ Acetyl tetrapeptide-11 0.05％ Glutathione 0.04％ Decarboxylated carnosine 0.06％ Vitamin E polyethylene glycol succinate 1.5％ glycerin 70％ Polysorbate-20 4.0％ Deionized water margin Specific preparation method: Same as in Example 1.

[0025] Example 4, Formulation of the composition Component Name Content percentage Tripeptide-1 0.025％ Acetyl tetrapeptide-11 0.04％ Glutathione 0.025％ Decarboxylated carnosine 0.04％ Vitamin E polyethylene glycol succinate 0.5％ Propylene glycol 70％ Polysorbate-20 4.0％ Deionized water margin Specific preparation method: Same as in Example 1.

[0026] Example 5, Formulation of the composition Component Name Content percentage Tripeptide-1 0.025％ Acetyl tetrapeptide-11 0.04％ Glutathione 0.025％ Decarboxylated carnosine 0.04％ Vitamin E polyethylene glycol succinate 0.04％ glycerin 70％ Polysorbate-20 4.0％ Deionized water margin Specific preparation method: Same as in Example 1.

[0027] Example 6, Formulation of the composition Component Name Content percentage Tripeptide-1 0.025％ Acetyl tetrapeptide-11 0.04％ Glutathione 0.03％ Decarboxylated carnosine 0.05％ Vitamin E polyethylene glycol succinate 0.5％ Butylene glycol 60％ Polysorbate-60 4.0％ Deionized water margin Specific preparation method: Same as in Example 1.

[0028] Comparative Example 1, Formulation of the composition Component Name Content percentage Acetyl tetrapeptide-11 0.04％ Glutathione 0.025％ Decarboxylated carnosine 0.04％ Vitamin E polyethylene glycol succinate 1.0％ glycerin 70％ Polysorbate-20 4.0％ Deionized water margin Specific preparation method: Same as in Example 1. Comparative Example 2, Formulation of the composition Component Name Content percentage Tripeptide-1 0.025％ Glutathione 0.025％ Decarboxylated carnosine 0.04％ Vitamin E polyethylene glycol succinate 1.0％ glycerin 70％ Polysorbate-20 4.0％ Deionized water margin Specific preparation method: Same as in Example 1.

[0029] Comparative Example 3, Formulation of the composition Component Name Content percentage Tripeptide-1 0.025％ Acetyl tetrapeptide-11 0.04％ Decarboxylated carnosine 0.04％ Vitamin E polyethylene glycol succinate 1.0％ glycerin 70％ Polysorbate-20 4.0％ Deionized water margin Specific preparation method: Same as in Example 1.

[0030] Comparative Example 4, Formulation of the composition Component Name Content percentage Tripeptide-1 0.025％ Acetyl tetrapeptide-11 0.04％ Glutathione 0.025％ Vitamin E polyethylene glycol succinate 1.0％ glycerin 70％ Polysorbate-20 4.0％ Deionized water margin Specific preparation method: Same as in Example 1.

[0031] Comparative Example 5, Formulation of the composition Component Name Content percentage Tripeptide-1 0.025％ Acetyl tetrapeptide-11 0.04％ Glutathione 0.025％ Decarboxylated carnosine 0.04％ glycerin 70％ Polysorbate-20 4.0％ Deionized water margin Specific preparation method: Same as in Example 1.

[0032] Verification Example 1: Experiment 1: Stability Performance Test 1.1 Experimental objective: To test the accelerated stability of the compositions obtained in Examples 1-6 and Comparative Examples 1-5.

[0033] 1.2 Experimental conditions: The stability of the prepared composition samples was tested under the following conditions for one month: room temperature, light (natural light), low temperature (-15℃), high temperature (45℃), high and low temperature cycling (45℃ / -15℃ for 24 hours each), and refrigeration (5℃). The data after one month are recorded in Table 1.

[0034] Table 1. Results of accelerated stability test of the composition after one month sample normal temperature illumination low temperature high temperature High and low temperature cycling refrigeration Example 1 No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities Example 2 No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities Example 3 No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities Example 4 No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities Example 5 No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities Example 6 No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities Comparative Example 1 No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities Comparative Example 2 No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities Comparative Example 3 No abnormalities precipitate layering No abnormalities No abnormalities No abnormalities No abnormalities Comparative Example 4 No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities No abnormalities Comparative Example 5 precipitate layering Color-changing layering precipitate layering Color change Color-changing layering precipitate layering As shown in Table 1, the compound samples of the present invention (Examples 1-6) showed no abnormal changes after one month of stability testing, indicating that the compound solutions were of stable quality. Comparative Example 3, which did not contain glutathione, exhibited precipitation under light conditions. Comparative Example 5, which did not contain vitamin E polyethylene glycol succinate, showed poor stability under the same conditions. It is evident that the addition of vitamin E polyethylene glycol succinate can effectively solve the problem of poor stability in the above-mentioned peptide compositions, especially in the application of tripeptide-1, a peptide with extremely poor stability.

[0035] Experimental Example 2: Whitening Efficacy Test Tyrosinase inhibition rate whitening efficacy test 2.1 Experimental Objectives and Principles This experiment references the laboratory method (HMC-WI-032 tyrosinase inhibition rate) and compares the experimental samples with the negative control to determine the tyrosinase inhibition rate.

[0036] Melanin is synthesized by melanocytes. First, tyrosinase in melanocytes is activated, converting tyrosine into dopa. Then, dopa is further oxidized to form dopaquinone. Dopaquinone undergoes a series of chemical reactions, gradually polymerizing to form melanin precursors. These precursors then undergo further modification and maturation, ultimately forming mature melanin. Finally, melanin is transported and stored in specific sites within melanocytes, or transported to surrounding keratinocytes, thus affecting the color of skin, hair, and other pigments.

[0037] Tyrosinase is a key enzyme that catalyzes the conversion of dopa to dopaquinone in a phosphoric acid solution at pH 6.8. The absorbance can be measured at 475 nm using a spectrophotometer. Cosmetics that inhibit tyrosinase activity can reduce the conversion of dopa to dopaquinone, thereby lowering the absorbance. The inhibitory effect of cosmetics on tyrosinase activity can be evaluated based on changes in absorbance.

[0038] 2.2 Experimental Indicators Criteria for judging the tyrosinase inhibition rate of the test index: If the tyrosinase inhibition rate of the sample of this invention is higher than that of the negative control and the difference is significant (P<0.05), then the test sample can be considered to have a certain whitening effect.

[0039] 2.3 Experimental Materials and Methods Instruments and equipment: BSA224S analytical balance; RT-6100 enzyme-linked immunosorbent assay (ELISA) analyzer.

[0040] Reagents: Polyphenol oxidase (mushrooms), BR; Levodopa, BR.

[0041] 2.4 Experimental Methods (1) Processing of control materials and experimental samples The composition samples in Examples 1-6 and Comparative Examples 1-5 were diluted with pure water to a sample mass concentration of 2%. Positive control group (kojic acid, purity > 96%): diluted with pure water to a positive control concentration of 0.1%; Negative control group: pure water.

[0042] (2) Experimental procedure Set up sample tubes, sample background tubes, enzyme reaction tubes, and solvent background tubes. Each group should have 3 parallel tubes. Add different reagent solutions to each of the four groups, shake gently, and let stand at room temperature for 5 minutes. Transfer each group's reaction solution into a 1 cm cuvette and measure the absorbance at 475 nm.

[0043] (3) Calculation formula Tyrosinase inhibition rate (%) = (%) = (1 - (T - T0) / (C - CO)) * 100% Where: T - absorbance of the sample tube, i.e. absorbance of the solution after the sample reacts with tyrosinase; T0 - background absorbance of the sample; C - average of three absorbance values ​​of the enzyme reaction tube, i.e. absorbance of the reaction between tyrosinase and dopa without the addition of sample; C0 - background absorbance of the solvent.

[0044] (4) Data Analysis Statistical analysis was performed using SPSS software. Independent samples t-tests were used to compare the tyrosinase inhibition rates of the test samples, positive controls, and negative controls. All statistical analyses were two-tailed tests, with a significance level of α = 0.05. P > 0.05 indicated no significant difference between the two groups; P < 0.05 indicated a significant difference between the two groups.

[0045] 2.5 Experimental results: See Table 2.

[0046] Table 2. Results of Tyrosinase Inhibition Rate Test for Composition Samples sample Tyrosinase inhibition rate (%) p-value negative control 0.28±0.26 / Positive control 94.42±2.66 ＜0.05 Example 1 92.68±2.86 ＜0.05 Example 2 90.16±2.25 ＜0.05 Example 3 91.45±1.86 ＜0.05 Example 4 89.78±1.98 ＜0.05 Example 5 90.06±2.16 ＜0.05 Example 6 91.78±2.81 ＜0.05 Comparative Example 1 65.42±1.75 ＜0.05 Comparative Example 2 64.86±2.21 ＜0.05 Comparative Example 3 70.46±1.82 ＜0.05 Comparative Example 4 62.54±1.87 ＜0.05 Comparative Example 5 81.10±1.65 ＜0.05 The test results in Table 2 show that the tyrosinase inhibition rate of the positive control group was 94.42±2.66%, which is >50%, indicating that the reaction system was effective. The average tyrosinase inhibition rate was significantly different from that of the negative control (P<0.05), indicating that the product has a certain whitening effect. The tyrosinase inhibition rates of the compositions in Examples 1-6 were all above 85%, while the tyrosinase inhibition rates of the compositions in Comparative Examples 1-6 were all below 70%. It can be seen that acetyl tetrapeptide-11, glutathione, decarboxycarnosine, and tripeptide-1 of the present invention, while acting on different targets, have a good synergistic effect on whitening. In addition, the addition of vitamin E polyethylene glycol succinate promotes the mutual solubility of various peptide compounds, enhances the skin absorption of each peptide compound, and allows them to fully exert their whitening effect. Vitamin E polyethylene glycol succinate and various peptide compounds exert a good synergistic whitening effect.

[0047] Experimental Example 3: Cell proliferation after photodamage 3.1 Experimental Principle: The CCK-8 assay kit is used for rapid and sensitive detection of cell proliferation. Its working principle is as follows: In the presence of an electron coupling agent, WST-8 (2-(2-methoxy-4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfonylbenzene)-2H-tetrazole monosodium salt) can be reduced by mitochondrial dehydrogenases to generate a highly water-soluble orange-yellow formazan product. The intensity of its color is directly proportional to cell proliferation, reflecting the number of viable cells. After photodamage, the CCK-8 kit is used to test the effect of the test sample on cell proliferation, thus reflecting the antioxidant level of the test sample.

[0048] 3.2 Test Samples: The compositions of Examples 1-6 and Comparative Examples 1-5, each representing 2% by mass, were prepared using DMEM medium containing 10% fetal bovine serum as a solvent.

[0049] 3.3 Experimental Procedure: HaCaT human keratinocytes were seeded into 96-well plates (10,000 cells / well) and cultured at 37°C for 24 h. After culture, the original culture medium in the wells was discarded. DMEM culture medium containing 10% serum was added to the control and modeling groups, while test samples were added to each well of the sample groups. Each group had 5 replicates, and the cells were cultured for 24 h. After culture, the supernatant was discarded, and the cells were analyzed using 30 mJ / cm² water. 2 HaCaT human keratinocytes in the modeling group and the sample group were irradiated with UVB for 30 min. The control group was cultured normally without UV irradiation. After incubation for 24 h, the culture medium was discarded, and DMEM culture medium containing 10% CCK-8 was added and cultured in the dark for 2 h. The absorbance of each well was measured at 450 nm using a microplate reader.

[0050] The results show that the greater the absorbance, the more obvious the cell proliferation, the better the antioxidant effect of the sample, and the better the effect against photodamage.

[0051] 3.4 Experimental Results: See Table 3 below: Table 3 Absorbance results of each composition sample sample Absorbance (450nm) control group 2.168 Modeling Group 1.043 Example 1 2.083 Example 2 1.869 Example 3 1.985 Example 4 1.835 Example 5 1.826 Example 6 1.978 Comparative Example 1 1.552 Comparative Example 2 1.585 Comparative Example 3 1.468 Comparative Example 4 1.385 Comparative Example 5 1.686 Table 3 shows that the control group, cultured normally without UV irradiation, exhibited high absorbance values. In the modeling group, cells irradiated with UV after the addition of culture medium, without any added sample, showed slow cell proliferation and the lowest absorbance values ​​after UV damage. After adding samples from Examples 1-6 and Comparative Examples 1-5, cell growth was faster than in the modeling group without samples, with absorbance values ​​falling between the two, indicating that the samples from Examples 1-6 and Comparative Examples 1-5 have antioxidant and anti-photodamage effects. However, the samples from Comparative Examples 1-4 lacked tripeptide-1, acetyl tetrapeptide-11, glutathione, and decarboxylated carnosine, respectively, resulting in a correspondingly weakened proliferation effect. Comparative Example 5 lacked vitamin E polyethylene glycol succinate, although vitamin E polyethylene glycol succinate was not reported to be directly effective in cell proliferation. However, experimental data shows that vitamin E polyethylene glycol succinate promotes cell absorption and has a synergistic effect in polypeptide compositions of tripeptide-1, acetyl tetrapeptide-11, glutathione, and decarboxylated carnosine.

Claims

1. A skin repair composition for whitening and resisting photodamage, characterized in that, The composition comprises the following components in weight percentages: 0.015-0.03% tripeptide-1, 0.03-0.05% acetyl tetrapeptide-11, 0.02-0.04% glutathione, 0.03-0.06% decarboxylated carnosine, 0.05-1.5% vitamin E polyethylene glycol succinate, 60-70% polyol, 1-5% solubilizer, and the balance being water.

2. The composition according to claim 1, characterized in that, The composition comprises the following components in weight percentages: 0.020-0.025% tripeptide-1, 0.03-0.04% acetyl tetrapeptide-11, 0.025-0.03% glutathione, 0.04-0.05% decarboxylated carnosine, 0.5-1.5% vitamin E polyethylene glycol succinate, 60-70% polyol, 3-5% solubilizer, and the balance being water.

3. The composition according to claim 1, characterized in that, The composition comprises the following components in weight percentages: 0.025% tripeptide-1, 0.04% acetyl tetrapeptide-11, 0.025% glutathione, 0.04% decarboxylated carnosine, 1.0% vitamin E polyethylene glycol succinate, 70% polyol, 4% solubilizer, and the balance being water.

4. The composition according to claim 1, characterized in that, The polyol is selected from one or more of glycerol, butylene glycol, propylene glycol, and hexanediol; preferably glycerol.

5. The composition according to claim 1, characterized in that, The solubilizer is one or more of polysorbate-20, polysorbate-60, and polysorbate-80; preferably polysorbate-20.

6. The use of the composition according to any one of claims 1-5 in the preparation of cosmetics.

7. An essence, characterized in that, The serum comprises the composition as described in any one of claims 1-5.

8. A method for preparing a skin repair composition for whitening and resisting photodamage as described in any one of claims 1-5, characterized in that, Specifically, it includes the following steps: Step 1: Weigh out the prescribed amounts of polyol, solubilizer, tripeptide-1, and decarboxylated carnosine, dissolve them in an appropriate amount of water, and homogenize them; Step 2: Dissolve the prescribed amounts of acetyl tetrapeptide-11, glutathione, and vitamin E polyethylene glycol succinate in an appropriate amount of water to prepare a mixed solution; Step 3: Pour the solution from Step 1 into the mixture from Step 2, mix well, add water to the full volume, stir evenly, homogenize, and obtain the composition.