Fluid filtration system and method of conditioning fluid filtration system

Abstract

The invention relates to a fluid filtration system and a method of conditioning a fluid filtration system. Embodiments of a fluid filtration system constructed according to the principles of the present disclosure may be used to automatically adjust a single use filter for efficient use thereof. For example, in an embodiment, a fluid filtration system may include a filter conditioning procedure including at least one of a filter perfusion module, a filter flush module, and a filter pressurization module.

Description

[0001] This application is a divisional application of Chinese Invention Patent Application No. 202211721077.9, filed on December 30, 2022, entitled "Fluid Filtration System and Method for Regulating Fluid Filtration System". Cross-references to related applications

[0002] This patent application claims priority to U.S. Nonprovisional Patent Application No. 18 / 062,337, filed December 6, 2022, entitled “Volume-filling system with tandem fluid filter assembly and method thereof for automatic air transfer”, and U.S. Nonprovisional Patent Application No. 63 / 295,833, filed December 31, 2021, entitled “Fluid filtration system with disposable filter and method thereof for automatic filter conditioning”, both of which are incorporated herein by reference in their entirety. Technical Field

[0003] This application relates to a fluid filtration system and a method for regulating a fluid filtration system. Background Technology

[0004] In biopharmaceutical applications, the use of single-use systems (SUS) is becoming increasingly widespread. SUS can be used in systems such as bioreactors and mixing systems. Exemplary upstream SUS applications include media preparation processes, such as mixing and filtration, including tangential flow filtration (TFF). Examples of downstream SUS applications include, for example, chromatographic concentration and double filtration, as well as buffer preparation.

[0005] One aspect of biopharmaceutical processing involves managing the movement of liquids through a vast number of components, including tubing, valves, filters, and sensors. Compared to conventional reusable stainless steel systems, SUS (Stainless Steel) offers several advantages. Single-use technology increases process flexibility, reduces the risk of cross-contamination, reduces or even eliminates the need for cleaning, reduces the requirement for internal sterilization (e.g., autoclaving) and cleaning chemical inventories, and minimizes process downtime.

[0006] Adequate filter priming and wetting can be part of various filtration processes to help ensure reliable and adequate filter performance during filtration. During these operations, human interaction and improper component setup can lead to malfunctions and / or reduced filter performance.

[0007] There is a persistent need in the art for single-use applications related to fluid filtration. For example, there is a continued need for additional solutions to filter liquids aseptically under improved filter conditioning conditions for use in their intended applications.

[0008] It should be understood that this background description has been created to assist the reader and should not be considered as an indication that any problem indicated is itself understood in the art. While the principles described may mitigate problems inherent in other systems in some respects and embodiments, it should be understood that the scope of the protected innovation is defined by the appended claims, and not by the ability of any disclosed feature to solve any of the problems described herein. Summary of the Invention

[0009] In one aspect, this disclosure relates to embodiments of a fluid filtration system. In one embodiment, the fluid filtration system includes a workstation, a pump, a first disposable filter, a second disposable filter, a fluid supply line, a series filter line, a first ventilation duct, a second ventilation duct, and a control unit.

[0010] The workstation includes a cabinet. The pump is supported by the cabinet and is adapted to selectively generate fluid flow.

[0011] The first disposable filter is removably installed to the workstation. The first disposable filter has an upstream end and a downstream end. The second disposable filter is also removably installed to the workstation. The second disposable filter has an upstream end and a downstream end.

[0012] The upstream end of the first disposable filter is in fluid communication with the pump via a fluid supply conduit. The fluid supply conduit includes a first vent joint and a fluid supply valve. The fluid supply valve is located between the first vent joint and the pump.

[0013] The downstream end of the first disposable filter is in fluid communication with the upstream end of the second disposable filter via a series filter conduit. The series filter conduit includes a second vent joint and a series filter valve. The series filter valve is located between the downstream end of the first disposable filter and the second vent joint.

[0014] The first ventilation duct is in fluid communication with a first ventilation node of the fluid supply duct, such that the upstream end of the first disposable filter is in fluid communication with the first ventilation duct via the first ventilation node. The first ventilation duct includes a first outlet, a first liquid sensor, and a first ventilation valve. The first liquid sensor is disposed between the first ventilation node and the first outlet. The first ventilation valve is disposed between the first liquid sensor and the first outlet. The first liquid sensor is configured to generate a first liquid detection signal in response to detecting liquid in the first ventilation duct.

[0015] The second ventilation duct is in fluid communication with the second ventilation node of the series filter duct, such that the upstream end of the second disposable filter is in fluid communication with the second ventilation duct via the second ventilation node. The second ventilation duct includes a second outlet, a second liquid sensor, and a second ventilation valve. The second liquid sensor is disposed between the second ventilation node and the second outlet. The second ventilation valve is disposed between the second liquid sensor and the second outlet. The second liquid sensor is configured to generate a second liquid detection signal in response to detecting liquid in the second ventilation duct.

[0016] The control unit is electrically in communication with a first liquid sensor and a second liquid sensor to receive a first liquid detection signal and a second liquid detection signal from them, respectively. The control unit includes a processor and a non-transitory computer-readable medium carrying a filter conditioning program, the filter conditioning program including a filter filling module. The processor is arranged together with the computer-readable medium to execute the filter conditioning program. The processor is configured to perform a filling operation on a first disposable filter and a second disposable filter based on instructions from the filter filling module.

[0017] In another embodiment, the fluid filtration system includes a first disposable filter and a second disposable filter, a fluid supply conduit, a series filter conduit, a first ventilation duct, a second ventilation duct, and a control unit. The first and second disposable filters each have an upstream end and a downstream end.

[0018] The upstream end of the first disposable filter is in fluid communication with a fluid supply conduit. The fluid supply conduit includes a first vent joint and a fluid supply valve. The first vent joint is located between the fluid supply valve and the upstream end of the first disposable filter.

[0019] The downstream end of the first disposable filter is in fluid communication with the upstream end of the second disposable filter via a series filter conduit. The series filter conduit includes a second vent joint and a series filter valve. The series filter valve is located between the downstream end of the first disposable filter and the second vent joint. The second vent joint is located between the series filter valve and the upstream end of the second disposable filter.

[0020] A first ventilation duct is in fluid communication with a first ventilation node of a fluid supply duct, such that the upstream end of a first disposable filter is in fluid communication with the first ventilation duct via the first ventilation node. A second ventilation duct is in fluid communication with a second ventilation node of a series filter duct, such that the upstream end of a second disposable filter is in fluid communication with the second ventilation duct via the second ventilation node. The second ventilation duct includes a second ventilation liquid sensor. The second ventilation liquid sensor is configured to generate a second liquid detection signal in response to detecting liquid in the second ventilation duct.

[0021] The control unit is in electrical communication with a second ventilated liquid sensor to receive a second liquid detection signal from it. The control unit includes a processor and a non-transitory computer-readable medium carrying a filter conditioning program, the filter conditioning program including a filter filling module. The processor is arranged together with the computer-readable medium to execute the filter conditioning program. The processor is configured to perform filling operations on a first disposable filter and a second disposable filter based on instructions from the filter filling module.

[0022] In another aspect, this disclosure relates to embodiments of a technique for regulating a single-use filter in a fluid filtration system. In one embodiment, the method of regulating the fluid filtration system includes removably mounting a first and a second single-use filter to a workstation. The workstation includes a cabinet.

[0023] The upstream end of the first disposable filter is fluidly connected to the pump via a fluid supply conduit. The pump is supported by a cabinet. The fluid supply conduit includes a first vent joint and a fluid supply valve. The fluid supply valve is located between the first vent joint and the pump.

[0024] The downstream end of the first disposable filter is fluidly connected to the upstream end of the second disposable filter via a series filter conduit. The series filter conduit includes a second vent junction and a series filter valve. The series filter valve is located between the downstream end of the first disposable filter and the second vent junction.

[0025] Open the fluid supply valve to open the fluid supply line. Open the series filter valve to open the series filter line. Operate the pump to deliver fluid flow towards the upstream end of the second disposable filter, causing gas in the series filter line to shift via the second ventilation node to the second ventilation duct. Stop pump operation in response to the cessation of receiving a second liquid detection signal, which occurs in response to the detection of no liquid at a predetermined location in the second ventilation duct.

[0026] According to one aspect of this application, a fluid filtration system is provided, comprising: Integrity testing equipment; First disposable filter; A second disposable filter; and The system includes a fluid supply pipe, a first ventilation pipe, a second ventilation pipe, a first test pipe, and a second test pipe. The fluid supply pipe and the first test pipe are both in fluid communication with a first upstream end of the first disposable filter. The first ventilation pipe and the first test pipe are both in fluid communication with the integrity testing device. The fluid filtration system further includes: The series filter conduit connects the first downstream end of the first disposable filter to the second upstream end of the second disposable filter via the series filter conduit. The second test conduit is also in fluid communication with the second upstream end of the second disposable filter. Both the second ventilation conduit and the second test conduit are in fluid communication with the integrity testing device. A first liquid sensor is installed in the first test pipe; and A second liquid sensor is installed in the second test pipe.

[0027] In one embodiment, a first test pipeline valve is disposed in the first test pipeline between the first liquid sensor and the integrity testing device; and / or, a second test pipeline valve is disposed in the second test pipeline between the second liquid sensor and the integrity testing device.

[0028] In one embodiment, a first air filter is disposed in the first test pipeline between the first test pipeline valve and the integrity testing device; and / or, a second air filter is disposed in the second test pipeline between the second test pipeline valve and the integrity testing device.

[0029] In one embodiment, the fluid supply conduit is configured to selectively supply fluid to the first disposable filter; and the series filter conduit is configured to selectively open and close.

[0030] In one embodiment, the integrity testing apparatus is configured to selectively supply pressurized gas to the first disposable filter via the first test conduit; and / or, the integrity testing apparatus is configured to selectively supply pressurized gas to the second disposable filter via the second test conduit.

[0031] In one embodiment, a fluid supply valve is disposed in the fluid supply pipeline upstream of the first disposable filter; and / or, a series filter valve is disposed in the series filter pipeline upstream of the second disposable filter.

[0032] In one embodiment, the first ventilation duct includes a first ventilation valve; and / or, the second ventilation duct includes a second ventilation valve.

[0033] In one embodiment, the fluid filtration system further includes a discharge conduit that is in fluid communication with a second downstream end of the second disposable filter.

[0034] In one embodiment, the integrity testing device has an upstream end and a downstream end. The upstream end of the integrity testing device is in fluid communication with a pressurized gas source, and the downstream end of the integrity testing device is in fluid communication with the first ventilation duct, the second ventilation duct, the first test duct, and the second test duct.

[0035] In one embodiment, the discharge conduit includes a first outlet and a second outlet, as well as a first outlet valve and a second outlet valve respectively associated with the first outlet and the second outlet.

[0036] In one embodiment, at least one of the fluid supply conduit and the series filter conduit includes a pressure sensor.

[0037] In one embodiment, the first ventilation duct further includes a first outlet, and the first ventilation valve is disposed between the first liquid sensor and the first outlet; and / or, the second ventilation duct further includes a second outlet, and the second ventilation valve is disposed between the second liquid sensor and the second outlet.

[0038] In one embodiment, a pump is disposed upstream of the fluid supply valve in the fluid supply conduit to selectively generate fluid flow in the fluid supply conduit.

[0039] In one embodiment, the series filter conduit includes a tailpipe section and a riser section.

[0040] In one embodiment, the tailpipe portion descends from a first downstream end of the first disposable filter to a point below a second upstream end of the second disposable filter, and the riser portion ascends from the tailpipe portion to a second upstream end of the second disposable filter.

[0041] In one embodiment, the first disposable filter has a first size, an additional first disposable filter having a second size can be installed in place of the first disposable filter, and the second size is larger than the first size; and / or, the second disposable filter has a first size, an additional second disposable filter having a second size can be installed in place of the second disposable filter, and the second size is larger than the first size.

[0042] According to another aspect of this application, a fluid filtration system is provided, comprising: a first pressurized gas supply conduit, a second pressurized gas supply conduit, a first disposable filter, a second disposable filter, a fluid supply conduit, a first ventilation duct, and a second ventilation duct. The fluid supply pipe and the first pressurized gas supply pipe are both in fluid communication with the first upstream end of the first disposable filter, and the first ventilation pipe is in fluid communication with the first pressurized gas supply pipe. The fluid filtration system further includes: The series filter conduit connects the first downstream end of the first disposable filter to the second upstream end of the second disposable filter via the series filter conduit. The second pressurized gas supply conduit is also in fluid communication with the second upstream end of the second disposable filter. The second ventilation conduit is in fluid communication with the second pressurized gas supply conduit. A first liquid sensor is installed in the first pressurized gas supply pipeline; and A second liquid sensor is installed in the second pressurized gas supply pipeline.

[0043] In one embodiment, the first pressurized gas supply pipe is fluidly connected to the first disposable filter via a first ventilation node, such that the first pressurized gas supply pipe and the first ventilation pipe share a first common branch; and the second pressurized gas supply pipe is fluidly connected to the second disposable filter via a second ventilation node, such that the second pressurized gas supply pipe and the second ventilation pipe (200) share a second common branch, the second common branch being different from the first common branch.

[0044] In one embodiment, the first pressurized gas supply pipeline is a first test pipeline, the second pressurized gas supply pipeline is a second test pipeline, and the fluid filtration system further includes: An integrity testing device has an upstream end and a downstream end. The upstream end of the integrity testing device is in fluid communication with a pressurized gas source, and the downstream end of the integrity testing device is in fluid communication with both the first test pipeline and the second test pipeline.

[0045] In one embodiment, a first test pipeline valve is disposed in the first test pipeline between the first liquid sensor and the integrity testing device; and / or, a second test pipeline valve is disposed in the second test pipeline between the second liquid sensor and the integrity testing device.

[0046] In one embodiment, a first air filter is disposed in the first test pipeline between the first test pipeline valve and the integrity testing device; and / or, a second air filter is disposed in the second test pipeline between the second test pipeline valve and the integrity testing device.

[0047] In one embodiment, the fluid supply conduit is configured to selectively supply fluid to the first disposable filter; and the series filter conduit is configured to selectively open and close.

[0048] In one embodiment, the integrity testing apparatus is configured to selectively supply pressurized gas to the first disposable filter via the first test conduit; and / or, the integrity testing apparatus is configured to selectively supply pressurized gas to the second disposable filter via the second test conduit.

[0049] In one embodiment, a fluid supply valve is disposed in the fluid supply pipeline upstream of the first disposable filter; and / or, a series filter valve is disposed in the series filter pipeline upstream of the second disposable filter.

[0050] In one embodiment, the first ventilation duct includes a first ventilation valve; and / or, the second ventilation duct includes a second ventilation valve.

[0051] In one embodiment, the fluid filtration system further includes a discharge conduit that is in fluid communication with a second downstream end of the second disposable filter.

[0052] In one embodiment, the discharge conduit includes a first outlet and a second outlet, as well as a first outlet valve and a second outlet valve respectively associated with the first outlet and the second outlet.

[0053] In one embodiment, at least one of the fluid supply conduit and the series filter conduit includes a pressure sensor.

[0054] In one embodiment, the first ventilation duct further includes a first outlet, and the first ventilation valve is disposed between the first liquid sensor and the first outlet; and / or, the second ventilation duct further includes a second outlet, and the second ventilation valve is disposed between the second liquid sensor and the second outlet.

[0055] In one embodiment, a pump is disposed upstream of the fluid supply valve in the fluid supply conduit to selectively generate fluid flow in the fluid supply conduit.

[0056] In one embodiment, the series filter conduit includes a tailpipe section and a riser section.

[0057] In one embodiment, the tailpipe portion descends from a first downstream end of the first disposable filter to a point below a second upstream end of the second disposable filter, and the riser portion ascends from the tailpipe portion to a second upstream end of the second disposable filter.

[0058] In one embodiment, the first disposable filter has a first size, an additional first disposable filter having a second size can be installed in place of the first disposable filter, and the second size is larger than the first size; and / or, the second disposable filter has a first size, an additional second disposable filter having a second size can be installed in place of the second disposable filter, and the second size is larger than the first size.

[0059] According to another aspect of this application, a filter skid is also provided, comprising: Cabinet; and A trolley, the cabinet mounted on top of the trolley, and the cabinet configured to house the hydraulic and automated equipment of a fluid filtration system, the cabinet defining an internal cavity, and the internal cavity housing an integrity testing device and a pair of disposable filters, the integrity testing device being selectively fluidly connected to the pair of disposable filters to perform at least one integrity test each.

[0060] Further and alternative aspects and features of the disclosed principles will be understood from the following detailed description and accompanying drawings. It should be understood that the fluid filtration system and method for regulating the fluid filtration system disclosed herein can be implemented in other and different embodiments and can be modified in various aspects. Therefore, it should be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and do not limit the scope of the appended claims. Attached Figure Description

[0061] Figure 1 This is a perspective view of one embodiment of a filter skid constructed according to the principles of this disclosure, which includes an embodiment of a fluid filtration system constructed according to the principles of this disclosure.

[0062] Figure 2 yes Figure 1 Another perspective view of the filter skid, with its cabinet indicated by dashed lines for illustration.

[0063] Figure 3 yes Figure 1 Side front view of the filter skid.

[0064] Figure 4 yes Figure 1 A schematic front view of the three sides of the filter skid.

[0065] Figure 5 This is a schematic diagram of an embodiment of a fluid filtration system constructed according to the principles of this disclosure, illustrating a filter integrity test operation.

[0066] Figure 6 yes Figure 5The schematic diagram of the fluid filtration system shown illustrates the fluid recovery operation.

[0067] Figure 7 This is a view of an embodiment of a graphical user interface suitable for use with an integrity testing procedure, constructed in accordance with the principles of this disclosure.

[0068] Figure 8 and Figure 9 yes Figure 5 The schematic diagram of the fluid filtration system shown illustrates the upstream filter filling operation.

[0069] Figure 10 yes Figure 5 The schematic diagram of the fluid filtration system shown illustrates the downstream filter filling operation.

[0070] Figure 11 yes Figure 5 The schematic diagram of the fluid filtration system shown illustrates the filter flushing operation.

[0071] Figure 12 yes Figure 5 The schematic diagram of the fluid filtration system shown illustrates the upstream filter pressurization operation used to enhance filter membrane wetting.

[0072] Figure 13 This is a perspective view of an embodiment of a filling skid constructed in accordance with the principles of this disclosure, including an embodiment of a fluid filtration system constructed in accordance with the principles of this disclosure.

[0073] Figure 14 yes Figure 13 The side front view of the filling skid shows a fluid filtration system with a pair of disposable filters arranged in series.

[0074] Figure 15 This is a schematic diagram of an embodiment of a fluid filtration system constructed according to the principles of this disclosure, showing a pair of disposable filters arranged in series and adapted to... Figure 13 Use it with a filling skid.

[0075] Figure 16 Is it like this? Figure 15 The schematic diagram of the fluid filtration system in the image illustrates the air transfer operation.

[0076] Figure 17 Is it like this? Figure 15 The schematic diagram of the fluid filtration system further illustrates the air transfer operation.

[0077] It should be understood that the accompanying drawings are not necessarily drawn to scale, and the disclosed embodiments are shown in an illustrative manner and in partial views. In some cases, details that are not necessary for understanding this disclosure or that make other details difficult to understand may have been omitted. It should be understood that this disclosure is not limited to the specific embodiments shown herein. Detailed Implementation

[0078] Embodiments of the fluid filtration system constructed according to the principles of this disclosure are suitable for use with embodiments of methods for regulating a single-use filter in a fluid filtration system according to the principles of this disclosure. In embodiments, the fluid filtration system is incorporated into a filter skid or filling skid, which includes at least one single-use filter mounted thereon and a device incorporated into the skid, the device being configured to perform at least one regulation operation on the single-use filter, for example, a filling operation controlled by a control unit based on computer-executable instructions stored on a computer-readable medium.

[0079] Embodiments of fluid filtration systems constructed according to the principles of this disclosure can be used in biopharmaceutical environments, but also in other industrial applications involving the filtration of various fluids, solutions, reagents, and / or chemicals. For example, embodiments of fluid filtration systems constructed according to the principles of this disclosure are suitable for use in biological processing systems, where supplied fluids are separated and filtered (e.g., chromatographic / tangential flow filtration (TFF) applications) in biological processing applications. Embodiments of fluid filtration systems constructed according to the principles of this disclosure can be used to perform applications related to formulation and filling, as well as other applications related to the aseptic filtration of liquids.

[0080] Embodiments of the fluid filtration system constructed according to the principles of this disclosure are equipped with a filter integrity testing ("FIT") device, which is integrated into the control unit of the filter skid to achieve repeatable, reliable, and fully automated filter integrity testing, seamlessly handling in-situ, pre-use, and post-use filter integrity testing. Embodiments of the fluid filtration system constructed according to the principles of this disclosure are configured to perform field tests together with the integrated FIT device according to a predetermined test protocol, without requiring additional human interaction to perform the FIT.

[0081] Embodiments of fluid filtration systems constructed according to the principles of this disclosure include a FIT device incorporated into a filter skid and configured to aid in the recovery of filtered product from an exhaust duct by directionally applying a pressurized gas flow (e.g., pressurized air or nitrogen) through the filter via the FIT device. The product recovered as fluid can be forced through the filter and into the product outlet of the exhaust duct via the operation of the FIT device, following a predetermined operating procedure.

[0082] Embodiments of the fluid filtration system constructed according to the principles of this disclosure can be used to automatically adjust a disposable filter for efficient use. For example, in an embodiment, the fluid filtration system may include a filter conditioning procedure comprising at least one of a filter filling module, a filter flushing module, and a filter pressurization module.

[0083] In one embodiment, the fluid filtration system may include a filter conditioning procedure configured to facilitate the filling and wetting of a filter, including a single-use filter. In another embodiment, the fluid filtration system includes a conduit configured to deliver a pressurized gas flow upstream of the filter to enhance wetting. In yet another embodiment, an integrity testing device may be used to provide a pressurized gas source to enhance wetting via a FIT test operation. The results of this FIT test operation may be ignored in some applications. In other embodiments, other devices configured to provide an appropriate pressurized gas flow upstream of the filter may be used, as will be readily understood by those skilled in the art.

[0084] Now turn to the attached diagram. Figure 1-4 An embodiment of a fluid filtration system 20 constructed according to the principles of this disclosure is shown, which is incorporated into a workstation in the form of a filter skid 22 constructed according to the principles of this disclosure. In the embodiment, the filter skid 22 includes at least one disposable filter 25 and an integrity testing device 30 (e.g., see...). Figure 2 The integrity testing device is selectively fluidly connected to a disposable filter 25 to perform at least one FIT.

[0085] refer to Figure 1-3 The illustrated filter skid 22 includes a cabinet 32, a pump 34, multiple pre-filters 35, a pair of disposable filters 25, a fluid supply line 37, a discharge line 38, an integrity testing device 30, a test line 40, a control unit 45, and a display device 50. Those skilled in the art will understand upon review of this disclosure that the system may have different configurations in other embodiments. For example, in embodiments, the pre-filters 35 may be omitted, and / or only one disposable filter 25 may be provided.

[0086] In an embodiment of the fluid filtration system 20 constructed according to the principles of this disclosure, the upstream end 52 of each disposable filter 25 is fluidly connected to a pump 34 via a fluid supply conduit 37 and to an integrity testing device 30 via a test conduit 40. The pump 34 and the integrity testing device 30 are supported by a cabinet 32. The integrity testing device 30 is adapted to be fluidly connected to a pressurized gas source. The integrity testing device 30 is operable to guide a pressurized gas flow through the test conduit 40 to perform a test operation on each disposable filter 25. In embodiments, the test operation includes one of a forward flow test, a water intrusion test, a bubble point test, a leak test, and a pressure decay test. In embodiments, the fluid filtration system 20 can be used with any suitable fluid, which can be stored in a suitable container (e.g., a tank) in fluid communication with the pump 34.

[0087] refer to Figure 1 The filter skid 22 includes a trolley 55. A cabinet 32 ​​is mounted on top of the trolley 55 and configured to house the hydraulic and automated equipment of the fluid filtration system 20. The trolley 55 includes a base 57 and a plurality of wheels 58 rotatably attached to the base 57. In the illustrated embodiment, the base 57 is rectangular, and wheels 58 are rotatably attached to each corner of the base 57. In another embodiment, the base 57 may be generally square.

[0088] The cabinet 32 ​​is mounted to the base 57 of the trolley 55. In an embodiment, the cabinet 32 ​​includes storage units for automated and hydraulic equipment and is made of a suitable metal such as stainless steel. The cabinet 32 ​​defines an internal cavity that can be suitably configured to store and support components of a liquid filtration system, including an integrity testing device 30. (Reference) Figure 2 In one embodiment, the cabinet 32 ​​houses at least one pump body 34, an integrity testing device 30, and a control unit 45.

[0089] Pump 34 is supported by housing 32 and is adapted to selectively generate a fluid flow. Pump 34 is configured to draw fluid from a fluid supply device (not shown) and deliver that fluid to a filter. Pump 34 is operatively coupled to control unit 45, allowing control unit 45 to selectively operate pump 34. Pump 34 is adapted to selectively generate a fluid flow to supply fluid to the filter. In embodiments, pump 34 can be any suitable pump capable of generating a liquid flow through the filter that meets the specifications of the intended application. In embodiments, pump 34 includes a variable displacement pump. In embodiments, fluid filtration system 20 includes a plurality of pumps 34 that can be used to deliver one or more types of fluid to filters 35, 25.

[0090] refer to Figure 1 and Figure 2The pre-filter 35 is fluidly connected to the pump 34 in parallel via a fluid supply line 37. (Reference) Figure 1 The disposable filter 25 is fluidly connected in parallel to the pre-filter group 35 via a fluid supply conduit 37. The parallel pre-filter group 35 is connected in series with the parallel pair of disposable filters 25.

[0091] refer to Figure 1 In the illustrated embodiment, each conduit 37, 38, 40 includes a pipe arrangement that fluidly interconnects the various components of the fluid filtration system 20. In this embodiment, the pipe arrangement includes multiple flexible conduits adapted to be selectively shut off by externally mounted pinch valves. In this embodiment, the flexible conduits can be made of any suitable material, such as silicone, thermoplastic elastomers (TPE), etc. In this embodiment, the conduits include flexible, plastic-based hoses (e.g., PVC, PP, PE). In this embodiment, the conduits include any of a range of suitable materials and components readily known to those skilled in the art, such as silicone tubing, plastic injection-molded adapters, and commercially available connectors and disconnectors (e.g., Kleenpack® Presto sterile connectors and Kleenpack® sterile disconnectors from Parr Corporation, Port Washington, NY), as well as those disclosed in U.S. Patent Application Publication US2017 / 0284584.

[0092] In one embodiment, the filter skid 22 may have several valve arrangements associated with piping. In another embodiment, each piping 37, 38, 40 may be associated with a control valve that is electrically in communication with a control unit 45, which is then configured to control the operating conditions of the valve between open and closed conditions to direct fluid flow through the valve. These valves may include any suitable valves adapted to selectively close the associated piping.

[0093] In the illustrated embodiment, the valves include pinch valves adapted to control fluid flow within the system by blocking the pipe of the pipe, thereby effectively blocking the associated pipe. The valves are secured to skid 22, and means for removably mounting pipes 37, 38, 40 to skid 22 can be provided. These valves are supported by a housing 32 such that a clamping portion of each valve extends from the outer surface of the housing 32 to be associated with a pipe, respectively. In other embodiments, different types of valves, readily familiar to those skilled in the art, such as solenoid valves, can be used. In embodiments, the valves can be operated by a suitable source, such as a pneumatic or electric source. In embodiments, the operation of the valves on the filter skid 22 can be coordinated via a control unit 45, which is appropriately programmed to operate one or more desired fluid distribution sequences.

[0094] refer to Figure 1The pre-filter 35 and the single-use filter 25 are removably mounted to the cabinet 32. In the illustrated embodiment, the filter skid 22 includes four pre-filters 35 and two single-use filters 25. In other embodiments, the filter skid 22 may include different numbers of pre-filters 35 and / or single-use filters 25, including one pre-filter 35 and / or one single-use filter 25. In some embodiments, the pre-filters 35 may be omitted.

[0095] refer to Figure 1 Each disposable filter 25 is removably mounted to workstation 22. Each disposable filter 25 has an upstream end 52 and a downstream end 54. The upstream end 52 of each disposable filter 25 is in fluid communication with pump 34 via fluid supply conduit 37 (see also...). Figure 2 Each disposable filter 25 is in fluid communication with the downstream end 54 of the discharge pipe 38.

[0096] In the illustrated embodiment, each disposable filter 25 includes a replaceable portion that is installed once in the filter skid 22 for use in a biological treatment application and then removed for further processing. After its intended use in the biological treatment application is complete, the corresponding disposable filter 25 can be detached from the filter skid 22 and replaced with another disposable filter 25 having a similar structure. In the embodiment, the filter 25 comprises any of a range of suitable materials and components, which will be readily apparent to those skilled in the art.

[0097] Various commercially available filters, filter media (e.g., fiber media, membranes, and / or composites), filter elements, filter modules, and filter sizes are suitable for use as pre-filter 35 and disposable filter 25 in embodiments of fluid filtration systems constructed according to the principles of this disclosure. Suitable filters include, for example, Pegasus Prime filters available from Parr Corporation in Port Washington, New York. Exemplary filters and filter elements include pleated filters and “LOP” filter configurations.

[0098] In embodiments, the pre-filter 35 and the single-use filter 25 comprise filters and filter elements having any suitable pore structure, such as pore size (e.g., as demonstrated by bubbling point, or by KL as described, for example, in U.S. Patent 4,340,479, or by capillary condensation flow method), pore grade, pore diameter (e.g., when characterized using, for example, the modified OSU F2 test described in U.S. Patent 4,925,572), or removal rate that reduces or allows one or more target substances to pass through as fluid flows through the element. The pore structure used depends on the composition of the fluid to be treated and the desired effluent level of the fluid being treated.

[0099] In embodiments, the pre-filter 35 and the single-use filter 25 comprise filters and filter elements having any desired critical wetting surface tension (CWST, such as that defined in, for example, U.S. Patent 4,925,572). The porous membrane may have any desired critical wetting surface tension (CWST, such as that defined in, for example, U.S. Patent 4,925,572). The CWST can be selected as is known in the art, for example, as otherwise disclosed in U.S. Patents 5,152,905, 5,443,743, 5,472,621, and 6,074,869. The surface properties of the element (e.g., influencing the CWST, including surface charge (e.g., positive or negative charge), and / or altering the polarity or hydrophilicity of the surface) can be modified by wet or dry oxidation, by coating or depositing a polymer on the surface, or by grafting reactions. Modifications include, for example, radiation, polar or charged monomers, coating and / or curing the surface with a charged polymer, and chemical modification to attach functional groups to the surface.

[0100] In embodiments, the pre-filter 35 and the disposable filter 25 may include additional elements, layers, or components that may have different structures and / or functions, such as at least one of the following: pre-filtration, support, discharge, spacing, and buffering. Illustratively, in embodiments, the pre-filter 35 and the disposable filter 25 may also include at least one additional element, such as a mesh and / or screen.

[0101] In an embodiment, the pre-filter 35 and the disposable filter 25 include multiple filter elements (typically, filters are arranged between the outer cage and the inner core to provide a filter module) disposed within a housing that includes an inlet and an outlet and defines a fluid flow path between the inlet and the outlet, wherein the filter spans the fluid flow path. Preferably, as is known in the art, the pre-filter 35 and the disposable filter 25 are sterilizable (e.g., autoclaved, irradiated with gamma rays, etc.). Any housing with a suitable shape and providing an inlet and an outlet can be used.

[0102] refer to Figure 1 The discharge conduit 38 is in fluid communication with the downstream end 54 of each disposable filter 25. The discharge conduit 38 includes a first outlet 61 and a second outlet 62, and a first outlet valve 63 and a second outlet valve 64 associated with the first outlet 61 and the second outlet 62, respectively. The first outlet 61 is adapted to be in fluid connection with a product container, and the second outlet 62 is adapted to be in fluid connection with a waste storage area.

[0103] refer to Figure 2 The integrity testing device 30 is supported by a cabinet 32 ​​and is in fluid communication with the upstream end 52 of each disposable filter 25 via a test pipe 40 (see also...). Figure 1 The integrity testing device 30 is adapted to connect to a pressurized gas source (e.g., pressurized air or nitrogen) and selectively direct the pressurized gas flow through a corresponding test conduit 40 to each disposable filter 25. The test conduit 40 may include a high-pressure manifold section located upstream of the disposable filter 25, configured to selectively deliver pressurized gas to one or both disposable filters 25. The test conduit 40 may include a stainless steel gas line from the integrity testing device 30 to the manifold section.

[0104] In this embodiment, any integrity testing apparatus 30 suitable for performing the desired integrity tests can be used. In this embodiment, a commercially available integrity testing apparatus configured to perform pre-use and post-use integrity tests can be used. In this embodiment, various integrity testing instruments are suitable for use, such as the PALLTRONIC Flowstar IV filter integrity tester, PALLTRONIC Flowstar IV filter integrity tester MUX Extension, PALLTRONIC Flowstar LGR tester, or PALLTRONIC AquaWIT IV filter integrity test system, all commercially available from PALLTRONIC Corporation, Port Washington, New York.

[0105] In this embodiment, the integrity testing device 30 is configured to perform various filter integrity tests (FITs), which are familiar to those skilled in the art, including pre-use sterilization and post-use tests. In this embodiment, the integrity testing device 30 is configured to perform FITs designed to ensure consistent filtration performance according to regulatory agencies (e.g., the FDA). In this embodiment, the integrity testing device 30 is configured to perform at least one FIT according to a regulatory protocol to ensure that the filter performance meets regulatory performance specifications. In this embodiment, the integrity testing device 30 is configured to perform each of the following tests according to at least one predetermined protocol: forward flow test, water ingress test, bubble point test, leak test, and pressure decay test.

[0106] refer to Figure 2 In this embodiment, the control unit 45 may include any suitable device configured to control the operation of at least one component of the liquid filtration system 20 during the execution of a filtration operation. In this embodiment, the control unit 45 includes a processor 71, a non-transitory computer-readable medium 72 carrying a fluid filtration program, a data storage device 73, and a display device 50. The processor 71 is arranged together with the computer-readable medium 72 to execute the fluid filtration program. The processor 71 and the display device 50 are operatively arranged to selectively display output information from the fluid filtration program and / or receive input information from a graphical user interface displayed on the display device 50.

[0107] In one embodiment, the processor 71 of the control unit 45 includes both a separate processor and a processor included in the integrity testing apparatus 30. In another embodiment, the fluid filtration process includes an integrity testing program. In yet another embodiment, the integrity testing apparatus 30 includes a non-transitory computer-readable medium carrying the integrity testing program. The processor 71, together with the computer-readable medium 72, is arranged to execute the integrity testing program. The processor 71 is in electrical communication with the integrity testing apparatus 30 to selectively operate the integrity testing apparatus 30 based on instructions from the integrity testing program to perform a test operation on each disposable filter 25 using a pressurized gas flow.

[0108] In one embodiment, the fluid filtration process includes a filter conditioning process, which comprises at least one of a filter filling module, a filter flushing module, and a filter pressurization module.

[0109] The processor 71 can be configured as a controller to selectively operate at least one component of the fluid filtration system 20, such as the pump 34 and the valve arrangement. In an embodiment, the processor 71 is in electrical communication with the pump and valve arrangement to selectively operate the valves based on instructions from the fluid filtration program.

[0110] In embodiments, the controller and processor 71 may comprise separate devices, and the controller may be operatively communicatively arranged with the processor 71. In embodiments, the controller may include a user input and / or interface device having one or more user-actuated mechanisms (e.g., one or more buttons, sliders, rotatable knobs, keyboards, and mice) adapted to generate one or more user-actuated input control signals. In embodiments, the controller may be configured to include one or more other user-activated mechanisms to provide various other control functions for the fluid filtration system, as will be understood by those skilled in the art. The controller may be associated with a display device 50 adapted to display a graphical user interface. In embodiments, the graphical user interface may be configured to function as both a user input device and a display device. In embodiments, the display device 50 may include a touchscreen device adapted to receive input signals from a user touching different portions of the display screen. In embodiments, the controller may be in the form of a smartphone, tablet computer, personal digital assistant (e.g., a wireless mobile device), laptop computer, desktop computer, or other types of device.

[0111] In embodiments, processor 71 may include any suitable computing device, such as a microprocessor, mainframe computer, digital signal processor, portable computing device, personal electronic memo pad, device controller, logic device (e.g., a programmable logic device configured to perform processing functions), digital signal processing (DSP) device, or computing engine within a home appliance. In embodiments, processor 71 may also include one or more additional input devices (e.g., a keyboard and mouse).

[0112] The processor 71 may have one or more associated storage devices for storing data and information. The one or more storage devices may include any suitable type, including volatile and non-volatile storage devices, such as RAM (Random Access Memory), ROM (Read-Only Memory), EEPROM (Electrically Erasable Programmable Read-Only Memory), flash memory, etc.

[0113] In one embodiment, the control unit 45 is in electrical communication with each pump 34 for supplying fluid to filters 35, 25 and with each valve in the valve arrangement. The control unit 45 is configured to selectively operate the pumps 34 and valves according to logic and operating parameters included in the fluid filtration procedure. In another embodiment, the control unit 45 is configured to control at least one of the pump speed and the volumetric displacement of the pump 34 to control the amount of fluid delivered to the disposable filter 25. In the illustrated embodiment, the control unit 45 is configured to independently operate each valve of the different valve arrangement.

[0114] In one embodiment, processor 71 includes a specially programmed processor that facilitates the control and operation of the fluid filtration system 20. In another embodiment, processor 71 may be configured to receive input signals from a controller, send input control signals to the controller, and / or send output information to the controller. In the illustrated embodiment, the controller and processor 71 include the same device, and the integrity testing device 30 includes its own processor that can be controlled by processor 71.

[0115] In one embodiment, processor 71 is adapted to execute a program stored on a non-transitory computer-readable medium 72 to perform various methods, processes, and modes of operation in accordance with the principles of this disclosure. In an embodiment, the non-transitory computer-readable medium 72 may include a fluid filtration program configured to implement embodiments of a method for filtering fluids according to the principles of this disclosure. In an embodiment, the fluid filtration program is configured to perform at least one fluid filtration operation. In an embodiment, the fluid filtration program is configured to perform at least one fluid recovery operation.

[0116] In one embodiment, the fluid filtration program includes a graphical user interface that can be displayed by the display device 50. The graphical user interface can be used to facilitate the user inputting commands and data into the fluid filtration program and to display the output generated by the fluid filtration program.

[0117] The fluid filtration program can be stored on any suitable computer-readable storage medium. For example, in embodiments, a fluid filtration program following the principles of this disclosure can be stored on a hard disk drive, floppy disk drive, CD-ROM drive, magnetic tape drive, zip drive, flash memory drive, optical storage device, magnetic storage device, and similar devices.

[0118] In one embodiment, processor 71 is operatively in communication with data storage device 73, which includes at least one database containing fluid filtration data. In another embodiment, the fluid filtration program can be configured to store fluid filtration data generated during system operation in data storage device 73. In yet another embodiment, the fluid filtration data can be logically associated with time data in the data storage device, such that various data can be retrieved within a given time period.

[0119] The display device 50 and the processor 71 are operatively arranged. In an embodiment, the integrity test procedure is configured to perform the following steps as part of a test operation when executed by the processor 71: determining whether each disposable filter 25 satisfies the test operation; generating a graphical display containing a graphical indication of whether the disposable filter 25 satisfies the test operation; and displaying the graphical display on the display device 50 (e.g., see...). Figure 7 ).

[0120] In one embodiment, the processor 71 is configured to display fluid filtration data received from the integrity testing device 30 and from at least one sensor electrically communicating with the control unit 71 on the display device 50. The fluid filtration data may also be stored in a data storage device 73 operatively arranged with the processor 71.

[0121] Figure 5 This is a schematic diagram of one embodiment of a fluid filtration system 20 constructed according to the principles of this disclosure, illustrating a filter integrity test operation. The illustrated arrangement includes a single-use filter 25. It should be understood that this arrangement (and...) Figure 6 and Figure 8-12 The description of those shown applies to each disposable filter 25 included in a particular embodiment of a fluid filtration system constructed in accordance with the principles of this disclosure.

[0122] The fluid supply line 37 includes a fluid supply valve 81 and a test junction 82. The test line 40 is fluidly connected to the disposable filter 25 via the test junction 82 of the fluid supply line 37.

[0123] Test line 40 includes an air filter 85, a test line valve 86, and a liquid sensor 87. The air filter 85 is configured to filter particles from the fluid passing through it. The air filter 85 is positioned between the integrity testing device 30 and the disposable filter 25, such that pressurized gas supplied from the integrity testing device 30 to the disposable filter 25 is filtered through the air filter 85. Test line 40 includes the liquid sensor 87 and the test line valve 86 to protect the air filter 85 from exposure to liquid.

[0124] Liquid sensor 87 is configured to generate a liquid detection signal in response to detecting liquid in test pipe 40. Control unit 45 is in electrical communication with liquid sensor 87 to receive the liquid detection signal from the liquid sensor. Test pipe valve 86 is arranged together with test pipe 40 to selectively close test pipe 40.

[0125] Liquid sensor 87 is disposed between integrity testing device 30 and test node 82, particularly between air filter 85 and test node 82. Test pipeline valve 86 is disposed between air filter 85 and liquid sensor 87.

[0126] The test line valve 86 is operatively arranged with the control unit 45 such that the control unit 45 can operate the test line valve 86 in response to receiving a liquid detection signal. In an embodiment, the control unit 45 is configured to stop the operation of the pump 34 and / or close the test line valve 86 in response to receiving a liquid detection signal to prevent the air filter 85 from being wetted by liquid.

[0127] In one embodiment, the fluid filtration system 20 may include means for removing trapped gas within the ductwork to enhance the accuracy and consistency of the fluid filtration process. In the illustrated embodiment, the test duct 40 also includes a ventilation junction 88 for fluid communication with a ventilation duct 90. The ventilation duct 90 is in fluid communication with the test duct 40 via the ventilation junction 88.

[0128] Ventilation duct 90 includes ventilation valve 91. Ventilation valve 91 is operatively arranged with control unit 45 such that control unit 45 can selectively operate ventilation valve 91.

[0129] In an embodiment, the integrity test procedure may be configured to perform the following steps as part of a test operation when executed by the processor 71: closing the fluid supply valve 81 to block the fluid supply pipe 37; opening the test pipe valve 86 to open the test pipe 40; opening the second outlet valve 64 to allow airflow through the disposable filter 25; and operating the integrity test device 30 to guide pressurized gas flow through the test pipe 40 and through the disposable filter 25. In an embodiment, the test operation includes one of a forward flow test, a water intrusion test, a bubble point test, a leak test, and a pressure decay test. In an embodiment, the integrity test procedure is configured to perform the following steps as part of a test operation when executed by the processor: closing the vent valve 91 to block the vent pipe 90.

[0130] In one embodiment, the integrity test procedure may be configured to perform the following steps as part of a test operation when executed by the processor: closing the first outlet valve 63 to block the first outlet 61; and opening the second outlet valve 64 to open the second outlet 62. In another embodiment, the integrity test procedure may omit the execution of these steps, but they help to avoid unwanted fluid at the product outlet (which could cause unnecessary / undesirable dilution). In other embodiments, the integrity test procedure may be configured to perform the reverse steps as part of a test operation when executed by the processor, i.e., opening the first outlet valve 63 to open the first outlet 61, and closing the second outlet valve 64 to close the second outlet 62.

[0131] The discharge pipe 38 includes a pressure sensor 93. The pressure sensor 93 is configured to generate a pressure signal indicating the pressure measured in the discharge pipe 38. The control unit 45 is in electrical communication with the pressure sensor 93 to receive the pressure signal from the pressure sensor. In an embodiment, the pressure sensor 93 can be used to confirm that the discharge pipe 38 is unpressurized.

[0132] In one embodiment, the FIT device 30 includes an internal pressure sensor that can operate independently to sense pressure in the test conduit 40. In another embodiment, the integrity test procedure is configured to determine whether test conditions for the test operation are met based on pressure measured by the pressure sensor of the FIT device 30 in the upstream portion of the disposable filter 25 within the area of ​​test node 82.

[0133] In an embodiment, the fluid filtration system 20 may include means for recovering fluid from a single-use filter that would otherwise be retained in the single-use filter or not discharged during the filtration operation. Figure 6 This is a schematic diagram of the fluid filtration system 20, illustrating fluid recovery operation. After use, the fluid filtration system 20 can be operated to recover fluid from the single-use filter 25 by guiding pressurized gas through the filter 25. The fluid supply valve 81 can be closed to prevent fluid from flowing from the fluid supply line 37 to the upstream end 52 of the single-use filter 25. The fluid supply valve 81 can be closed to ensure that the pressure (air) provided by the FIT device 30 is used to recover product from the single-use filter 25 (rather than flowing / flowing through the fluid supply line 37). The integrity testing device 30 can supply pressurized gas through the single-use filter 25. The product outlet of the discharge line 38 can be opened to allow fluid driven from the single-use filter 25 to exit from the downstream end 54 of the filter 25 through the discharge line 38 from the product outlet 61. In other embodiments, a separate pressurized gas source can be provided for the fluid recovery operation.

[0134] Figure 7 This is a view of one embodiment of a graphical user interface 95 constructed according to the principles of this disclosure and suitable for use with an integrity testing procedure. In this embodiment, the integrity testing procedure is configured to determine whether a single-use filter 25 satisfies a test operation, generate a graphical display containing a graphical indication of whether the single-use filter 25 satisfies the test operation, and display this graphical display on a display device 50. The graphical user interface 95 is an example of such a graphical display.

[0135] refer to Figure 8-12 This shows a series of filter adjustment sequences. Figure 8 and Figure 9 yes Figure 5 The schematic diagram of the fluid filtration system shown illustrates the upstream filter priming operation. (Reference) Figure 8The upstream end 52 of the disposable filter 25 is in fluid communication with the pump 34 via a fluid supply conduit 37. The ventilation duct 90 is in fluid communication with the junction 82 of the fluid supply conduit 37, such that the upstream end 52 of the disposable filter 25 is in fluid communication with the ventilation duct 90 via the junction 82 and a common branch 97 extending between the junction 82 and the upstream end 52 of the disposable filter 25. The ventilation duct 90 includes an outlet 98, a liquid sensor 87, and a ventilation valve 91. The liquid sensor 87 is disposed between the junction 82 and the outlet 98. The ventilation valve 91 is disposed between the liquid sensor 87 and the outlet 98. The liquid sensor 87 is configured to generate a liquid detection signal in response to the detection of liquid in the ventilation duct 90.

[0136] Control unit 45 is electrically connected to liquid sensor 87 to receive liquid detection signals from the liquid sensor. In an embodiment, control unit 45 is programmed to have a filter conditioning program that includes a filter filling module. Processor 71 is electrically connected to pump 34, fluid supply valve 81, vent valve 91, and liquid sensor 87 to perform filling operations on disposable filter 25 based on instructions from the filter filling module.

[0137] In an embodiment, the filter filling module is configured to perform the following steps when executed by the processor 71: opening the fluid supply valve 81 to open the fluid supply conduit 37; opening the vent valve 91 to open the vent 90; closing the first outlet valve 63 to block the first outlet 61 of the discharge conduit 38; opening the second outlet valve 64 to open the second outlet 62 of the discharge conduit 38; operating the pump 34 to deliver a fluid flow to the upstream end 52 of the disposable filter 25, such that gas in the fluid supply conduit 37 is discharged into the vent 90; and stopping the operation of the pump 34 and / or closing the vent valve 91 in response to receiving a liquid detection signal from the liquid sensor 87.

[0138] refer to Figure 9 The liquid has risen above node 82 and extends toward liquid sensor 87, indicating that the gas upstream of disposable filter 25 has been removed through ventilation duct 90.

[0139] Figure 10 yes Figure 5 The schematic diagram of the fluid filtration system shown illustrates the downstream filter filling operation. In response to the liquid sensor 87 detecting the presence of liquid, the control unit 45 has closed the test pipeline valve 86 and the vent valve 91.

[0140] In an embodiment, the filter filling module is configured to perform a downstream filter filling operation including the following steps when executed by the processor 71: closing vent valves 86, 91; opening fluid supply valve 81 to open fluid supply conduit 37; closing first outlet valve 63 to block first outlet 61 of discharge conduit 38; opening second outlet valve 64 to open second outlet 62 of discharge conduit 38; operating pump 34 to deliver fluid flow through disposable filter 25 to upstream end 52 of disposable filter 25 and out from second outlet 62 of discharge conduit 38; and stopping operation of pump 34 after a predetermined amount of time or in response to pressure in discharge conduit 38 reaching a predetermined value based on pressure signal from pressure sensor 93.

[0141] Figure 11 yes Figure 5 The schematic diagram of the fluid filtration system illustrates the filter flushing operation. In this embodiment, the control unit 45 is programmed to have a filter conditioning program that includes a filter flushing module.

[0142] In this embodiment, the filter flushing module is configured to perform the following steps as part of a flushing operation when executed by the processor 71: The test line valve 86 and the vent valve 91 are closed in response to receiving a liquid detection signal from the liquid sensor 87. The first outlet valve 63 is closed to block the first outlet 61 of the discharge line 38. The second outlet valve 64 is partially opened to partially open the second outlet 62 of the discharge line 38. The fluid supply valve 81 is opened to open the fluid supply line 37. The pump 34 is operated to deliver a fluid flow to the disposable filter 25, such that the fluid flow passes through the disposable filter 25 and the discharge line 38 and exits from the second outlet 62, thereby creating back pressure in the discharge line 38. The pressure sensor 93 can be used as a feedback loop for the control unit 45 to monitor and adjust the position / orifice of the outlet valve 64 to create a defined back pressure in the discharge line 38, thereby improving the wetting of the filter membrane.

[0143] In one embodiment, the filter flushing module is configured to sequentially open and close the second outlet valve 64 to sequentially open and close the second outlet 62, thereby generating a pulse effect in the discharge duct 38. This pulse effect can be modulated to help improve the wetting of the filter membrane.

[0144] Figure 12 yes Figure 5 The schematic diagram of the fluid filtration system illustrates the upstream filter pressurization operation. In an embodiment, test conduit 40 includes a pressurized gas supply conduit for supplying pressurized gas to the upstream end 52 of the disposable filter 25 to pressurize the upstream of the disposable filter 25.

[0145] The upstream end 52 of the disposable filter is in fluid communication with a pressurized gas supply line 40. The pressurized gas supply line 40 is adapted to selectively direct a flow of pressurized gas through it to the upstream end 52 of the disposable filter 25. In the illustrated embodiment, an integrity testing device 30 is used to pressurize the upstream end 52 of the disposable filter 25. In other embodiments, any suitable pressurized gas source can be used, and other suitable devices can be used to pressurize the gas, as will be readily understood by those skilled in the art. Examples of other techniques for providing a pressurized gas source include a suitable pump with a pressure gauge configured to deliver the pressurized gas source to a predetermined pressure setpoint. In this embodiment, the pressurized gas supply line 40 is adapted to connect to an external pressurized gas source (e.g., a pressure tank) and selectively direct a flow of pressurized gas through it to the upstream end 52 of the disposable filter 25.

[0146] In the illustrated embodiment, the pressurized gas supply line 40 includes an integrity testing device 30 adapted to connect to a gas source to pressurize the gas and selectively direct the pressurized gas flow through the pressurized gas supply line 40 to an upstream end 52 of the disposable filter 25. The processor 71 is in electrical communication with the integrity testing device 30 to selectively operate it. In other embodiments, the integrity testing device 30 may be omitted, and the pressurized gas supply line 40 may be in fluid communication with another device delivering pressurized gas (e.g., a pressure vessel and / or compressor).

[0147] The fluid supply conduit 37 includes a first node at its junction 82, and the pressurized gas supply conduit 40 includes a second node (ventilation node 88). The ventilation conduit 90 is in fluid communication with the second node 88, such that the upstream end 52 of the disposable filter 25 is in fluid communication with the ventilation conduit 40 via the first node 82 and the second node 88, and such that a common branch 99 extends between the second node 88 and the upstream end 52 of the disposable filter 25.

[0148] The pressurized gas supply pipeline 40 includes a gas supply valve 86 and an air filter 85. A liquid sensor 87, the gas supply valve 86, and the air filter 85 are disposed in a common branch 99. The liquid sensor is disposed between the first node 82 and the gas supply valve 86. The gas supply valve 86 is disposed between the liquid sensor 87 and the air filter 85.

[0149] In one embodiment, the filter conditioning procedure includes a filter pressurization module configured to perform the following steps as part of a pressurization operation when executed by the processor 71: Closing the fluid supply valve 81 to block the fluid supply conduit 37; closing the vent valve 91 to block the vent conduit 90; closing the first and second outlet valves 63, 64 to block the first and second outlets 61, 62 of the discharge conduit 38, respectively; and directing a pressurized gas flow through the pressurized gas supply conduit 40 to the upstream end 52 of the disposable filter 25. In another embodiment, the filter pressurization module may be configured to, when executed by the processor 71, sequentially open and close the gas supply valve 86 to sequentially open and close the pressurized gas supply conduit 40, thereby generating a pulse effect in the pressurized gas supply conduit 40.

[0150] refer to Figure 13 and 14 This illustrates another embodiment of a filter skid 122 constructed according to the principles of the present disclosure, which includes an embodiment of a fluid filtration system 120 constructed according to the principles of the present disclosure, having a pair of disposable filters 125, 126 fluidly connected in series (see [link to document]). Figure 14 besides Figure 15 ). refer to Figure 15 This illustrates a schematic diagram of an embodiment of a fluid filtration system 120 constructed according to the principles of this disclosure, which is suitable for use with... Figure 13 and 14 Used in conjunction with skid 122. As will be readily understood by those skilled in the art, skid 122 is in the form of a volume-filling system and is configured to accommodate disposable filters 125, 126 up to twenty-inch capsule sizes, such as Figure 15 As shown by the dashed line.

[0151] refer to Figure 13 and 14The illustrated dispenser skid 122 includes a cabinet 132, a pump 134, a pair of disposable filters 125 and 126 connected via a series filter conduit 128, a fluid supply conduit 137, an exhaust conduit 138, an integrity testing device (not shown), first and second test conduits 140 and 141, a first ventilation duct 190, a second ventilation duct 200, a control unit 145, and a display device 150. The pump 134 is supported by the cabinet 132 and is adapted to selectively generate a fluid flow. In embodiments, the fluid filtration system 120 can be used with any suitable fluid, which can be stored in a suitable container, such as a box, in fluid communication with the pump 134. The first and second disposable filters 125 and 126 are removably mounted to the cabinet 132. The upstream end 152 of each disposable filter 125 and 126 is fluidly connected to the pump 134 via the fluid supply conduit 137 (and, in the case of the second disposable filter 126, the series filter conduit 128), and connected to the integrity testing device via the test conduits 140 and 141. Integrity testing device 130 is supported by cabinet 132. In embodiments, the construction and operation of skid 122 may otherwise be similar to the dispenser skid shown and described in U.S. Patent Application No. 17 / 934,486 entitled “Fluid Dispensing System with Disposable Manifold Fluid Recovery Assembly,” the entire contents of which are incorporated herein by reference.

[0152] Those skilled in the art will understand, upon review of this disclosure, that the system may have different configurations in other embodiments. For example, in an embodiment, one or more pre-filters 135 may be disposed upstream of a pair of disposable filters 125, 126, and / or more than two disposable filters 125, 126 may be fluidly connected in series.

[0153] refer to Figure 15 The fluid filtration system 120 is configured for use with a range of disposable filters 125, 126 of different sizes, for example, sizes ranging from KA1 to NP7. Figure 15As shown. Gas retention in the series filter conduit 128 below the first disposable filter 125 can be left behind after a filter with a fill size smaller than NP7 (twenty inches) in a space otherwise occupied by a larger filter. If left in place, this gas will be flushed to the second disposable filter 126, causing air retention at the upstream end 152 of the second disposable filter 126, potentially reducing wetting of the second disposable filter 126 during flushing, and possibly allowing air to enter the filter itself. The problem of residual gas retained between the series disposable filters 125, 126 can be exacerbated by downstream components being positioned to accommodate the largest size filter within a filter size range (e.g., KA1 to NP7) to allow standard systems to be used for any filter within that size range. In an embodiment, the processor of the control unit 145 is configured to perform a fill operation on the first and second disposable filters 125, 126 based on instructions from a filter fill module carried on a non-transitory computer-readable medium, which can divert residual gas in the series filter conduit 128 to a location in the second ventilation conduit 200 just upstream of the upstream end 152 of the second disposable filter 126. The residual gas can be discharged into the atmosphere via the second ventilation duct 200 through the filling operation of the second disposable filter 126.

[0154] Figure 16 and 17 An air transfer operation performed by a fluid filtration system 120 is illustrated. The illustrated arrangement includes two disposable filters 125, 126. It should be understood that this description of the arrangement applies to embodiments of fluid filtration systems constructed according to the principles of this disclosure, which include more than two disposable filters fluidly connected in series. Reference Figure 16 The illustrated fluid filtration system 120 includes a pair of disposable filters 125 and 126 connected in series by filter conduits 128, a fluid supply conduit 137, an exhaust conduit 138, an integrity testing device 130, a pair of test conduits 140 and 141, a first ventilation conduit 190, and a second ventilation conduit 200. A pump 134 is in fluid communication with the fluid supply conduit 137 and is adapted to selectively generate fluid flow through the first and second disposable filters 125 and 126.

[0155] refer to Figure 16The upstream end 152 of the first disposable filter 125 is in fluid communication with the fluid supply conduit 137, and is also in fluid communication with the pump 134 via the fluid supply conduit 137. The fluid supply conduit 137 includes a fluid supply valve 181 and a first ventilation joint 182. The fluid supply valve 181 is disposed between the first ventilation joint 182 and the pump 134. The first ventilation joint 182 is disposed between the fluid supply valve 181 and the upstream end 152 of the first disposable filter 125.

[0156] Fluid supply conduit 137 includes a pressure sensor 183. The pressure sensor 183 is disposed between the pump 134 and the first vent junction 182, upstream of the first disposable filter 125. The pressure sensor 183 is configured to generate a pressure signal indicating the pressure measured in the fluid supply conduit 137. A control unit 145 is in electrical communication with the pressure sensor 183 to receive the pressure signal from it. In an embodiment, the pressure sensor 183 can be used to confirm that the pump 134 is supplying the required fluid flow to the first disposable filter 125.

[0157] The downstream end 154 of the first disposable filter 125 is in fluid communication with the upstream end 152 of the second disposable filter 126 via a series filter conduit 128. The series filter conduit 128 includes a series filter valve 201 and a second ventilation joint 202. The series filter valve 201 is disposed between the downstream end 154 of the first disposable filter 125 and the second ventilation joint 202. The second ventilation joint 202 is disposed between the series filter valve 201 and the upstream end 152 of the second disposable filter 126.

[0158] The series filter conduit 128 includes a tailpipe section 203 and a riser section 204. The tailpipe section 203 descends from the downstream end 154 of the first disposable filter 125 to a point 205 below the upstream end 152 of the second disposable filter 126. The riser section 204 ascends from the tailpipe section 203 to the upstream end 152 of the second disposable filter 126.

[0159] refer to Figure 15In an embodiment, the fluid filtration system 120 is configured for use with a size range of first and second disposable filters 125, 126. In the illustrated embodiment, the first and second disposable filters 125, 126 have a first size, and the first and second disposable filters 125', 126', shown in dashed lines, have a second size that is taller than the first size. The first and second disposable filters 125', 126' are adapted to be removably mounted to a workstation in place of the first and second disposable filters 125, 126. In this case, a second tailpipe 203' is used, which is shorter than, for example, the larger first and second disposable filters 125', 126' by an amount sufficient to accommodate the larger first and second disposable filters 125', 126'. Figure 16 The tailpipe 203 is shown.

[0160] Return to reference Figure 16 The series filter conduit 128 includes a pressure sensor 184. The pressure sensor 184 is located between the low point 205 and the second ventilation junction 202 of the riser section 203, downstream of the first disposable filter 125. The pressure sensor 184 is configured to generate a pressure signal indicating the pressure measured in the series filter conduit 128. The control unit 145 is in electrical communication with the pressure sensor 184 to receive the pressure signal from it. In an embodiment, the pressure sensor 184 can be used to detect whether residual gas is present in the tailpipe 203.

[0161] In one embodiment, at least one of the fluid supply line 137 and the series filter line 128 includes a pressure sensor. In the illustrated embodiment, both the fluid supply line 137 and the series filter line 128 include pressure sensors 183 and 184. Pressure sensors 183 and 184 are both electrically in communication with the control unit 145 to transmit their pressure signals to the control unit, respectively.

[0162] In an embodiment, the fluid filtration system 120 may include means for removing gas trapped within the ductwork to enhance the accuracy and consistency of the fluid filtration process. In the illustrated embodiment, the means includes first and second ventilation ducts 190, 200 and devices therein. The first ventilation duct 190 is in fluid communication with a first ventilation joint 182 of the fluid supply duct 137, such that the upstream end 152 of the first disposable filter 125 is in fluid communication with the first ventilation duct 190 via the first ventilation joint 182.

[0163] The first ventilation duct 190 includes a first outlet 198, a first ventilation liquid sensor 187, and a first ventilation valve 191. The first liquid sensor 187 is disposed between a first ventilation node 182 and the first outlet 198. The first ventilation valve 191 is disposed between the first liquid sensor 187 and the first outlet 198. The first ventilation liquid sensor 187 is configured to generate a first liquid detection signal in response to detecting liquid in the first ventilation duct 190.

[0164] Control unit 145 is in electrical communication with first ventilation liquid sensor 187 to receive a first liquid detection signal from it. First ventilation valve 191 is operably arranged with control unit 145 such that control unit 145 can selectively operate first ventilation valve 191 to open and close first ventilation duct 190.

[0165] The second ventilation duct 200 is in fluid communication with the second ventilation node 202 of the series filter duct 128, such that the upstream end 152 of the second disposable filter 126 is in fluid communication with the second ventilation duct 200 via the second ventilation node 202. The second ventilation duct 200 includes a second outlet 208, a second ventilation liquid sensor 207, and a second ventilation valve 211. The second ventilation liquid sensor 207 is disposed between the second ventilation node 202 and the second outlet 208. The second ventilation valve 211 is disposed between the second ventilation liquid sensor 207 and the second outlet 208. The second ventilation liquid sensor 207 is configured to generate a second liquid detection signal in response to detecting liquid in the second ventilation duct.

[0166] Control unit 145 is in electrical communication with second ventilation liquid sensor 207 to receive a second liquid detection signal from it. Second ventilation valve 211 is operably arranged with control unit 145 such that control unit 145 can selectively operate second ventilation valve 211 to open and close second ventilation duct 200.

[0167] The discharge conduit 138 is in fluid communication with the downstream end 154 of the second disposable filter 126. The discharge conduit 138 includes a first outlet 161 and a second outlet 162, and a first outlet valve 163 and a second outlet valve 164 associated with the first outlet 161 and the second outlet 162, respectively. The first outlet 161 is adapted to be in fluid connection with a product container, and the second outlet 162 is adapted to be in fluid connection with a waste storage area.

[0168] The discharge pipe 138 includes a pressure sensor 193. The pressure sensor 193 is configured to generate a pressure signal indicating the pressure measured in the discharge pipe 138. The control unit 145 is in electrical communication with the pressure sensor 193 to receive the pressure signal from it. In an embodiment, the pressure sensor 193 can be used to confirm that the discharge pipe 138 is not pressurized.

[0169] In the illustrated embodiment, pressurized gas supply lines 140, 141 include an integrity testing device 130 adapted to connect to a gas source to pressurize the gas and selectively direct the pressurized gas flow through one or both of the pressurized gas supply lines 140, 141 leading to an upstream end 52 of the first and second disposable filters 125, 126. The integrity testing device 130 is operable to direct the pressurized gas flow through the testing lines 140, 141 to perform testing operations on each disposable filter 125, 126, respectively. In this embodiment, the testing operations include one of a forward flow test, a water intrusion test, a bubble point test, a leak test, and a pressure decay test. A processor of a control unit 145 is electrically in communication with the integrity testing device 130 to selectively operate the integrity testing device 130. In other embodiments, the integrity testing device 130 may be omitted, and the pressurized gas supply lines 140, 141 may be in fluid communication with another device for delivering pressurized gas (e.g., a pressure tank and / or compressor).

[0170] Test conduits 140 and 141 are fluidly connected to disposable filters 125 and 126 via corresponding first and second ventilation joints 188 and 189, respectively, such that the first and second test conduits 140 and 141, as well as the first and second ventilation conduits 190 and 200, share corresponding first and second common branches 212 and 213. The first test conduit 140 includes a first air filter 185, a first test conduit valve 186, and a first ventilation liquid sensor 187. The second test conduit 141 includes a second air filter 214, a second test conduit valve 215, and a second ventilation liquid sensor 207.

[0171] The first and second air filters 185 and 214 are each configured to filter particulate matter from fluid passing through them. The first and second air filters 185 and 214 are respectively disposed between the integrity testing device 30 and the first and second disposable filters 125 and 126, such that pressurized gas delivered to the first and second disposable filters 125 and 126 via the integrity testing device 30 is filtered by the first and second air filters 185 and 214, respectively.

[0172] The first and second test conduits 140 and 141 respectively include first and second ventilation liquid sensors 187 and 207 and first and second test conduit valves 186 and 215 to protect the first and second air filters 185 and 214 from exposure to liquid. It should be understood that the discussion of the first ventilation liquid sensor 187 and the first test conduit valve 186 also applies to the second ventilation liquid sensor 207 and the second test conduit valve 215.

[0173] A first test line valve 186 is arranged together with a first test line 140 to selectively close the first test line 140. A first liquid sensor 187 is disposed between the integrity testing device 130 and the first ventilation node 182, particularly between the first air filter 185 and the first ventilation node 182. The first test line valve 186 is disposed between the first air filter 185 and the first liquid sensor 187.

[0174] The first test line valve 186 is operatively arranged with the control unit 145 such that the control unit 145 can operate the test line valve 186 in response to receiving a first liquid detection signal from the first vent liquid sensor 187. In an embodiment, the control unit 145 is configured to stop the operation of the pump 134 and / or close the first test line valve 186 in response to receiving the first liquid detection signal from the first vent liquid sensor 187 to prevent the air filter 185 from being wetted by liquid.

[0175] Control unit 145 is electrically in communication with first and second ventilation liquid sensors 187, 207 to receive first and second liquid detection signals from them, respectively. The control unit includes a processor and a non-transitory computer-readable medium carrying a filter conditioning program, which includes a filter filling module. The processor is arranged together with the computer-readable medium to execute the filter conditioning program. The processor is configured to perform filling operations on the first and second single-use filters based on instructions from the filter filling module.

[0176] In one embodiment, the control unit 145 is programmed with a filter conditioning program that includes a filter filling module. In embodiments following the principles of this disclosure, the filter filling module, when executed by the processor, is configured to release residual air (such as...) trapped in the series filter conduit 128. Figure 16 (As shown) The system 120 is used to transfer out the first and second disposable filters 125, 126 in series to facilitate the use of disposable filters of different sizes on a particular skid. In at least some of these embodiments, the filter filling module, when executed by a processor, is configured to fill the second disposable filter 126 after transferring residual air in the series filter conduit 128 to the second ventilation duct 200, such as... Figure 17As shown. In at least some of these embodiments, the filter filling module, when executed by the processor, is configured to fill the first disposable filter 125 after transferring residual air in the series filter conduit 128 to the second ventilation conduit 200. In at least some of these embodiments, the filter filling module, when executed by the processor, is configured to fill the first disposable filter 125 after transferring residual air in the series filter conduit 128 to the second ventilation conduit 200 and after filling the second disposable filter 126.

[0177] refer to Figure 16 In an embodiment, the filter filling module, when executed by the processor, is configured to perform the following steps to remove residual air trapped in the series filter conduit 128: opening the fluid supply valve 181 to open the fluid supply conduit 137, opening the series filter valve 201 to open the series filter conduit 128, and operating the pump 134 to deliver a fluid flow to the upstream end 152 of the second disposable filter 126, so that the gas (e.g., Figure 16 The pump 134 (as shown in tailpipe section 203) is shifted to the second ventilation duct 200, and operation of the pump 134 is stopped in response to the cessation of receiving the second liquid detection signal, which occurs in response to the detection of no liquid at the location of the second ventilation liquid sensor 207 in the second ventilation duct 200. In at least some of these embodiments, the filter filling module, when executed by the processor, is configured to fill the second disposable filter 126 after the operation of the pump 134 is stopped in response to the detection of no liquid at the second ventilation liquid sensor 207.

[0178] refer to Figure 17 In one embodiment, the filter filling module, when executed by the processor, is configured to fill the second disposable filter 126 after stopping the pump 134 in response to the detection of no liquid at the second ventilated liquid sensor 207, as... Figure 17As shown. In at least some of these embodiments, the filter filling module, when executed by the processor, is configured to perform the following steps as part of filling the second disposable filter 126 after stopping the pump 134 in response to the detection of no liquid at the second ventilation liquid sensor 207: opening the fluid supply valve 181 to open the fluid supply line 137, opening the series filter valve 201 to open the series filter line 128, opening the second ventilation valve 211 (and the second test line valve 215) to open the second ventilation line 200, operating the pump 134 to deliver a fluid flow to the upstream end 152 of the second disposable filter 126 such that gas upstream of the upstream end 152 of the second disposable filter 126 is displaced into the second ventilation line 200, stopping the operation of the pump 134 and / or closing the second ventilation valve 211 (and the second test line valve 215) in response to receiving a second liquid detection signal from the second ventilation liquid sensor 207.

[0179] In at least some of these embodiments, the filter filling module, when executed by the processor, is configured to perform the following steps as part of filling the second disposable filter 126: closing the second vent valve 211 in response to receiving a second liquid detection signal from the second vent liquid sensor 207, operating the pump 134 to deliver a fluid flow to the second disposable filter 126, such that the fluid flow passes through the second disposable filter 126 and the discharge pipe 138 and flows out of the second outlet 162.

[0180] In one embodiment, the filter filling module, when executed by the processor, is configured to fill the first disposable filter 125 after stopping the pump 134 in response to the detection of no liquid at the second vent liquid sensor 207. In at least some such embodiments, the filter filling module, when executed by the processor, is configured to perform the following steps as part of the filling operation: opening the fluid supply valve 181 to open the fluid supply conduit 137, opening the first vent valve 191 (and the first test conduit valve 186) to open the first vent 190, operating the pump 134 to deliver a fluid flow to the upstream end 152 of the first disposable filter 125, causing gas in the fluid supply conduit 137 to shift to the first vent 190, stopping the operation of the pump 134 and / or closing the first vent valve 191 (and the first test conduit valve 186) in response to receiving a first liquid detection signal from the first vent liquid sensor 187.

[0181] In at least some of these embodiments, the filter filling module, when executed by the processor, is configured to perform the following steps as part of the filling operation: closing the first outlet valve 163 to block the first outlet 161, opening the second outlet valve 164 to open the second outlet 162, closing the first vent valve 191 (and the first test pipe valve 186) in response to receiving a liquid detection signal from the first vent liquid sensor 187, operating the pump 134 to deliver a fluid flow to the first disposable filter 125, such that the fluid flows through the first disposable filter 125 and the discharge pipe 138 and out of the second outlet 162.

[0182] In other embodiments, the fluid filtration system may include different and additional devices configured to maintain a supply of fluid for delivery to a single-use filter. For example, in other embodiments, a fluid filtration system constructed according to the principles of this disclosure may include at least one tower configured to hold one or more tanks filled with fluid for use with the fluid filtration system. In other embodiments, a fluid filtration system constructed according to the principles of this disclosure may include at least one tank filled with fluid used in the system.

[0183] In other embodiments of the fluid filtration system constructed according to the principles of this disclosure, the fluid filtration system may be constructed in alternative forms. For example, in other embodiments, the fluid filtration system may be scaled up for larger volumes or reduced in size for laboratory use. In embodiments, the fluid filtration system constructed according to the principles of this disclosure can be used to process a variety of liquids to meet the requirements of a desired application.

[0184] In embodiments of the method of using a fluid filtration system in accordance with the principles of this disclosure, any suitable embodiment of the fluid filtration system based on the principles discussed herein may be used. In embodiments, the method of using a fluid filtration system in accordance with the principles of this disclosure includes using a filter skid having a FIT device integrated into the fluid filtration system in accordance with the principles of this disclosure. In specific implementations, the method of using a fluid filtration system in accordance with the principles of this disclosure includes performing an in-situ integrity test on a single-use filter.

[0185] In one embodiment, a method for performing in-situ integrity testing on a single-use filter includes removably mounting the single-use filter to a workstation. The workstation includes a cabinet. The upstream end of the single-use filter is fluidly connected to a pump via a fluid supply line and to an integrity testing device via a test line. The pump and the integrity testing device are supported by the cabinet. The integrity testing device is fluidly connected to a source of pressurized gas (e.g., pressurized air or nitrogen). The integrity testing device is operated to guide a flow of pressurized gas through the test line to perform a test operation on the single-use filter. In an embodiment, the test operation includes one of a forward flow test, a water intrusion test, a bubble point test, a leak test, and a pressure decay test. In an embodiment, operating the integrity testing device to perform the test operation includes determining whether test conditions for the test operation are met based on pressure measured within the discharge line. In an embodiment, the FIT device is configured to determine whether the test passes or fails based on a selected test method (forward flow, bubble point, pressure decay, etc.) and associated test parameters (e.g., pressure, flow rate, etc.).

[0186] In one embodiment, the integrity testing apparatus performs a test operation by using a processor to execute an integrity test program stored on a non-transitory computer-readable medium. In this embodiment, the processor executes the integrity test program to determine whether a single-use filter satisfies the test operation. A graphical display containing a graphical indication of whether the single-use filter satisfies the test operation is generated. The graphical display is displayed on a display device.

[0187] In one embodiment, the fluid supply conduit includes a fluid supply valve and a test junction. The test conduit includes a test conduit valve and is fluidly connected to a disposable filter via the test junction of the fluid supply conduit. In another embodiment, the method further includes closing the fluid supply valve to block the fluid supply conduit during a test operation. The test conduit valve is then opened to open the test conduit during the test operation.

[0188] In one embodiment, the test conduit includes a ventilation junction. In another embodiment, the method further includes closing a ventilation valve to block the ventilation conduit during a test operation. The ventilation conduit is in fluid communication with the test conduit via the ventilation junction. In yet another embodiment, the method further includes opening the ventilation valve to open the ventilation conduit after the test operation is completed, thereby allowing pressurized gas upstream of the disposable filter to escape from the test conduit and enter the ventilation conduit.

[0189] In one embodiment, the discharge conduit is in fluid communication with the downstream end of a disposable filter. The discharge conduit includes first and second outlets and first and second outlet valves associated with the first and second outlets, respectively. In another embodiment, the method further includes closing the first outlet valve to block the first outlet, which is in fluid communication with a product container. The second outlet valve is then opened to open the second outlet. The second outlet is in fluid communication with a waste storage area.

[0190] In one embodiment, the method further includes measuring the pressure within the discharge conduit. In another embodiment, the operational integrity testing apparatus for performing a test operation includes determining whether test conditions for the test operation are met based on the pressure measured within the discharge conduit. In yet another embodiment, the operational FIT apparatus does not include measuring the pressure within the discharge conduit (downstream of the disposable filter). Discharge conduit 38 is understood to be unpressurized because the waste outlet is unpressurized.

[0191] In one embodiment, the FIT device has an internal flow sensor and internal pressure, which can be operated to determine the pressure in the region of the test node of the test pipeline and the upstream portion of the disposable filter. In another embodiment, the method includes measuring the pressure within the test pipeline upstream of the disposable filter. In yet another embodiment, the operational integrity testing device, to perform a test operation, includes determining whether test conditions for the test operation are met based on the pressure measured within the test pipeline.

[0192] In one embodiment, the discharge conduit is in fluid communication with the downstream end of a disposable filter. The discharge conduit includes a first outlet and a second outlet, and a first outlet valve and a second outlet valve associated with the first outlet and the second outlet, respectively. In another embodiment, the method further includes closing the first outlet valve to block the first outlet. The first outlet is in fluid connection to a product container for receiving filtered fluid for final use. The second outlet valve is opened to open the second outlet. The second outlet is in fluid connection to a waste storage area. In other embodiments, the method further includes opening the first outlet valve to open the first outlet. The first outlet is in fluid connection to the product container. The second outlet valve is closed to block the second outlet. The second outlet is in fluid connection to a waste storage area.

[0193] In another aspect, this disclosure relates to embodiments of techniques for regulating a single-use filter in a fluid filtration system. In embodiments, any suitable embodiment of a fluid filtration system based on the principles discussed herein can be used for a method of regulating a single-use filter in a fluid filtration system following the principles of this disclosure. In one embodiment, a method of regulating a single-use filter in a fluid filtration system includes removably mounting the single-use filter to a workstation. The workstation includes a cabinet. The upstream end of the single-use filter is fluidly connected to a pump via a fluid supply conduit. The pump is supported by the cabinet. The fluid supply conduit includes a junction and a fluid supply valve. The fluid supply valve is disposed between the junction and the pump. The fluid supply valve is opened to open the fluid supply conduit.

[0194] In one embodiment, the method further includes closing a test pipeline valve and a vent valve in response to receiving a liquid detection signal. A first outlet valve is closed to block the first outlet of the discharge pipeline. The discharge pipeline is in fluid communication with the downstream end of a disposable filter. A second outlet valve is at least partially opened to at least partially open the second outlet of the discharge pipeline. A pump is operated to deliver a fluid flow to the disposable filter, such that the fluid flow passes through the disposable filter, enters the discharge pipeline, and exits from the second outlet of the discharge pipeline.

[0195] In one embodiment, the method further includes closing a fluid supply valve to block the fluid supply conduit; closing a vent valve to block the vent conduit; closing a first outlet valve to block the first outlet; closing a second outlet valve to block the second outlet; and directing a pressurized gas flow through a pressurized gas supply conduit to the upstream end of a disposable filter.

[0196] In other embodiments following the principles of this disclosure, the method of regulating the fluid filtration system includes removably mounting a first disposable filter and a second disposable filter to a workstation. The workstation includes a cabinet.

[0197] In embodiments following the principles of this disclosure, residual air trapped in the series filter conduit can be removed from the system to allow the use of disposable filters of different sizes on a specific skid, the series filter conduit fluidly connecting the first and second disposable filters in series. In one embodiment, the upstream end of the first disposable filter is fluidly connected to a pump via a fluid supply conduit. The pump is supported by a cabinet. The fluid supply conduit includes a first vent junction and a fluid supply valve. The fluid supply valve is disposed between the first vent junction and the pump.

[0198] The downstream end of the first disposable filter is fluidly connected to the upstream end of the second disposable filter via a series filter conduit. The series filter conduit includes a second vent junction and a series filter valve. The series filter valve is located between the downstream end of the first disposable filter and the second vent junction.

[0199] Open the fluid supply valve to open the fluid supply line. Open the series filter valve to open the series filter line. Operate the pump to deliver fluid flow towards the upstream end of the second disposable filter, causing gas in the series filter line to shift through the second ventilation node into the second ventilation duct. Stop pump operation in response to the cessation of receiving a second liquid detection signal, which occurs in response to the detection of no liquid at a predetermined location in the second ventilation duct.

[0200] In embodiments following the principles of this disclosure, the second disposable filter may be pre-filled after residual air in the series filter conduit has been transferred to the second ventilation conduit. In an embodiment, a fluid supply valve is opened to open the fluid supply conduit. A series filter valve is opened to open the series filter conduit. A second ventilation valve is opened to open the second ventilation conduit. A pump is operated to deliver a fluid flow to the upstream end of the second disposable filter, causing gas upstream of the upstream end of the second disposable filter to shift into the second ventilation conduit.

[0201] The operation of the pump is stopped and / or the second ventilation valve is closed in response to the detection of liquid at a predetermined location in the second ventilation duct, the detection being performed, for example, by using a second liquid sensor.

[0202] In at least some of these embodiments, the second ventilation valve is closed in response to the detection of liquid at a predetermined location in the second ventilation duct. A pump is operated to deliver a fluid flow to a second disposable filter, such that the fluid flow passes through the second disposable filter into a discharge duct and exits from its outlet.

[0203] In embodiments following the principles of this disclosure, the first disposable filter can be pre-filled after residual air in the series filter conduit has been transferred to the second ventilation conduit. In embodiments, the first and second disposable filters can be pre-filled as discussed above. The fluid supply valve, the series filter valve, and the outlet valve of the discharge conduit are opened. A pump draws liquid from the liquid inlet toward the downstream end of the second disposable filter. The pump stops when "no liquid" is detected at the second liquid sensor in the second ventilation conduit, which in embodiments is a result of gas trapped in the series filter conduit shifting to the middle section between the first and second disposable filters, exactly upstream of the second disposable filter. The second disposable filter can be re-filled as discussed above. In embodiments, the first disposable filter can be re-filled if the liquid level in the first ventilation conduit has dropped below the liquid level sensor in the first ventilation conduit.

[0204] In one embodiment, a fluid supply valve is opened to open a fluid supply conduit. A first vent valve is opened to open a first vent conduit in fluid communication with a first vent node. A pump is operated to deliver a fluid flow to the upstream end of a first disposable filter, causing gas in the fluid supply conduit to shift via the first vent node into the first vent conduit. Pump operation is stopped and / or the first vent valve is closed in response to detection of liquid at a predetermined location in the first vent conduit.

[0205] All references cited in this article, including publications, patent applications and patents, are incorporated herein by reference as if each reference were individually and specifically indicated as incorporated herein by reference and described in its entirety.

[0206] In the context of describing the invention (particularly in the context of the appended claims), the terms “a,” “the,” and “the,” and similar designations, should be interpreted as encompassing both singular and plural aspects, unless otherwise stated herein or obviously contradicted by the context. Unless otherwise stated, the terms “comprising,” “having,” “including,” and “with” should be interpreted as open-ended terms (i.e., meaning “including but not limited to”). Unless otherwise indicated herein, the enumeration of numerical ranges herein is intended only as a way of abbreviating each individual value falling within that range, and each individual value is incorporated into the specification as if it were separately described herein. Unless otherwise indicated herein or obviously contradicted by the context, all methods described herein may be performed in any suitable order. Unless otherwise required, the use of any and all examples or exemplary language (e.g., “such as”) provided herein is intended only to better illustrate the invention and does not constitute a limitation on the scope of the invention. No language in the specification should be construed as indicating that any unclaimed element is essential for carrying out the invention.

[0207] This document describes preferred embodiments of the invention, including the best modes known to the inventors for carrying out the invention. Variations of those preferred embodiments will become apparent to those skilled in the art upon reading the foregoing description. The inventors expect those skilled in the art to appropriately employ such variations, and the inventors wish to practice the invention in ways other than those specifically described herein. Therefore, the invention includes all modifications and equivalents of the subject matter set forth in the appended claims as permitted by applicable law. Moreover, unless otherwise indicated herein or clearly contradicted by the context, the invention covers any combination of the foregoing elements in all possible variations.

Claims

1. A fluid filtration system, comprising: Integrity testing device (130); First disposable filter (125); Second disposable filter (126); and The system includes a fluid supply pipe (137), a first ventilation pipe (190), a second ventilation pipe (200), a first test pipe (140), and a second test pipe (141), wherein the fluid supply pipe (137) and the first test pipe (140) are both in fluid communication with the first upstream end (152) of the first disposable filter (125), and the first ventilation pipe (190) and the first test pipe (140) are both in fluid communication with the integrity testing device (130). The fluid filtration system further includes: The series filter conduit (128) is connected in fluid communication with the second upstream end (152) of the second disposable filter (126) via the series filter conduit (128). The second test conduit (141) is also connected in fluid communication with the second upstream end (152) of the second disposable filter (126). The second ventilation conduit (200) and the second test conduit (141) are both connected in fluid communication with the integrity testing device (130). A first liquid sensor (187) is disposed in the first test pipe (140); and A second liquid sensor (207) is installed in the second test pipe (141).

2. The fluid filtration system according to claim 1, wherein, A first test pipeline valve (186) is disposed in the first test pipeline (140) between the first liquid sensor (187) and the integrity test device (130); and / or, a second test pipeline valve (215) is disposed in the second test pipeline (141) between the second liquid sensor (207) and the integrity test device (130).

3. The fluid filtration system according to claim 2, wherein, A first air filter (185) is disposed in the first test pipe (140) between the first test pipe valve (186) and the integrity test device (130); and / or, a second air filter (214) is disposed in the second test pipe (141) between the second test pipe valve (215) and the integrity test device (130).

4. The fluid filtration system according to any one of claims 1 to 3, wherein, The fluid supply conduit (137) is configured to selectively supply fluid to the first disposable filter (125); and the series filter conduit (128) is configured to selectively open and close.

5. The fluid filtration system according to any one of claims 1 to 4, wherein, The integrity testing device (130) is configured to selectively supply pressurized gas to the first disposable filter (125) via the first test conduit (140); and / or, the integrity testing device (130) is configured to selectively supply pressurized gas to the second disposable filter (126) via the second test conduit (141).

6. The fluid filtration system according to claim 5, wherein, A fluid supply valve (181) is disposed in the fluid supply pipe (137) upstream of the first disposable filter (125); and / or, a series filter valve (201) is disposed in the series filter pipe (128) upstream of the second disposable filter (126).

7. The fluid filtration system according to claim 6, wherein, The first ventilation duct (190) includes a first ventilation valve (191); and / or, the second ventilation duct (200) includes a second ventilation valve (211).

8. The fluid filtration system according to claim 7 further includes an outlet conduit (138) in fluid communication with a second downstream end (154) of the second disposable filter (126).

9. The fluid filtration system according to claim 8, wherein, The integrity testing device (130) has an upstream end and a downstream end. The upstream end of the integrity testing device is in fluid communication with a pressurized gas source, and the downstream end of the integrity testing device is in fluid communication with the first ventilation duct (190), the second ventilation duct (200), the first test duct (140), and the second test duct (141).

10. The fluid filtration system according to claim 9, wherein, The discharge pipe (138) includes a first outlet (161) and a second outlet (162), as well as a first outlet valve (163) and a second outlet valve (164) respectively associated with the first outlet (161) and the second outlet (162).

11. The fluid filtration system according to claim 10, wherein, At least one of the fluid supply pipe (137) and the series filter pipe (128) includes a pressure sensor.

12. The fluid filtration system according to claim 11, wherein, The first ventilation duct (190) further includes a first outlet (198), and the first ventilation valve (191) is disposed between the first liquid sensor (187) and the first outlet; and / or, the second ventilation duct (200) further includes a second outlet (208), and the second ventilation valve (211) is disposed between the second liquid sensor (207) and the second outlet (208).

13. The fluid filtration system according to claim 12, wherein, A pump (134) is disposed in the fluid supply pipe (137) upstream of the fluid supply valve (181) to selectively generate fluid flow in the fluid supply pipe (137).

14. The fluid filtration system according to claim 13, wherein, The series filter pipe (128) includes a tail pipe section (203) and a riser section (204).

15. The fluid filtration system according to claim 14, wherein, The tailpipe section (203) descends from the first downstream end (154) of the first disposable filter (125) to a point (205) below the second upstream end (152) of the second disposable filter (126), and the riser section (204) rises from the tailpipe section (203) to the second upstream end (152) of the second disposable filter (126).

16. The fluid filtration system according to claim 15, wherein, The first disposable filter (125) has a first size, and an additional first disposable filter (125') with a second size can be installed in place of the first disposable filter (125), and the second size is larger than the first size; and / or, the second disposable filter (126) has a first size, and an additional second disposable filter (126') with a second size can be installed in place of the second disposable filter (126), and the second size is larger than the first size.

17. A fluid filtration system, comprising: First pressurized gas supply pipe (140), second pressurized gas supply pipe (141), first disposable filter (125), second disposable filter (126), fluid supply pipe (137), first ventilation pipe (190), and second ventilation pipe (200). The fluid supply pipe (137) and the first pressurized gas supply pipe (140) are both in fluid communication with the first upstream end (152) of the first disposable filter (125), and the first ventilation pipe (190) is in fluid communication with the first pressurized gas supply pipe (140). The fluid filtration system further includes: A series filter conduit (128) is connected in fluid communication between the first downstream end (154) of the first disposable filter (125) and the second upstream end (152) of the second disposable filter (126) via the series filter conduit (128), and the second pressurized gas supply conduit (141) is also connected in fluid communication with the second upstream end (152) of the second disposable filter (126), and the second ventilation conduit (200) is connected in fluid communication with the second pressurized gas supply conduit (141); A first liquid sensor (187) is installed in the first pressurized gas supply pipe (140); and A second liquid sensor (207) is installed in the second pressurized gas supply pipe (141).

18. The fluid filtration system according to claim 17, wherein, The first pressurized gas supply pipe (140) is fluidly connected to the first disposable filter (125) via a first ventilation node (188) such that the first pressurized gas supply pipe (140) and the first ventilation pipe (190) share a first common branch (212); and the second pressurized gas supply pipe (141) is fluidly connected to the second disposable filter (126) via a second ventilation node (189) such that the second pressurized gas supply pipe (141) and the second ventilation pipe (200) share a second common branch (213), which is different from the first common branch (212).

19. The fluid filtration system according to claim 18, wherein, The first pressurized gas supply pipe (140) is a first test pipe, and the second pressurized gas supply pipe (141) is a second test pipe. The fluid filtration system further includes: The integrity testing device (130) has an upstream end and a downstream end. The upstream end of the integrity testing device is in fluid communication with a pressurized gas source, and the downstream end of the integrity testing device is in fluid communication with both the first test pipe and the second test pipe.

20. The fluid filtration system according to claim 19, wherein, A first test pipeline valve (186) is disposed in the first test pipeline between the first liquid sensor (187) and the integrity testing device (130); and / or, a second test pipeline valve (215) is disposed in the second test pipeline between the second liquid sensor (207) and the integrity testing device (130).

21. The fluid filtration system according to claim 20, wherein, A first air filter (185) is disposed in the first test pipeline between the first test pipeline valve (186) and the integrity testing device (130); and / or, a second air filter (214) is disposed in the second test pipeline between the second test pipeline valve (215) and the integrity testing device (130).

22. The fluid filtration system according to any one of claims 19 to 21, wherein, The fluid supply conduit (137) is configured to selectively supply fluid to the first disposable filter (125); and the series filter conduit (128) is configured to selectively open and close.

23. The fluid filtration system according to any one of claims 19 to 22, wherein, The integrity testing device (130) is configured to selectively supply pressurized gas to the first disposable filter (125) via the first test conduit; and / or, the integrity testing device (130) is configured to selectively supply pressurized gas to the second disposable filter (126) via the second test conduit.

24. The fluid filtration system according to claim 23, wherein, A fluid supply valve (181) is disposed in the fluid supply pipe (137) upstream of the first disposable filter (125); and / or, a series filter valve (201) is disposed in the series filter pipe (128) upstream of the second disposable filter (126).

25. The fluid filtration system according to claim 24, wherein, The first ventilation duct (190) includes a first ventilation valve (191); and / or, the second ventilation duct (200) includes a second ventilation valve (211).

26. The fluid filtration system of claim 25 further includes an outlet conduit (138) in fluid communication with a second downstream end (154) of the second disposable filter (126).

27. The fluid filtration system according to claim 26, wherein, The discharge pipe (138) includes a first outlet (161) and a second outlet (162), as well as a first outlet valve (163) and a second outlet valve (164) respectively associated with the first outlet (161) and the second outlet (162).

28. The fluid filtration system according to claim 27, wherein, At least one of the fluid supply pipe (137) and the series filter pipe (128) includes a pressure sensor.

29. The fluid filtration system according to claim 28, wherein, The first ventilation duct (190) further includes a first outlet (198), and the first ventilation valve (191) is disposed between the first liquid sensor (187) and the first outlet; and / or, the second ventilation duct (200) further includes a second outlet (208), and the second ventilation valve (211) is disposed between the second liquid sensor (207) and the second outlet (208).

30. The fluid filtration system according to claim 29, wherein, A pump (134) is disposed in the fluid supply pipe (137) upstream of the fluid supply valve (181) to selectively generate fluid flow in the fluid supply pipe (137).

31. The fluid filtration system according to claim 30, wherein, The series filter pipe (128) includes a tail pipe section (203) and a riser section (204).

32. The fluid filtration system according to claim 31, wherein, The tailpipe section (203) descends from the first downstream end (154) of the first disposable filter (125) to a point (205) below the second upstream end (152) of the second disposable filter (126), and the riser section (204) rises from the tailpipe section (203) to the second upstream end (152) of the second disposable filter (126).

33. The fluid filtration system according to claim 32, wherein, The first disposable filter (125) has a first size, and an additional first disposable filter (125') with a second size can be installed in place of the first disposable filter (125), and the second size is larger than the first size; and / or, the second disposable filter (126) has a first size, and an additional second disposable filter (126') with a second size can be installed in place of the second disposable filter (126), and the second size is larger than the first size.

34. A filter skid (122), comprising: Cabinet (132); as well as A trolley, the cabinet (132) is mounted on top of the trolley and the cabinet (132) is configured to house the hydraulic and automated equipment of the fluid filtration system, the cabinet (132) defining an internal cavity and housing an integrity testing device (130) and a pair of disposable filters (125, 126), the integrity testing device (130) being selectively fluidly connected to the pair of disposable filters (125, 126) to perform at least one integrity test each.

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