Quinoxaline compound and application thereof

By synthesizing quinoxaline compounds, the problem of insufficient inhibition of LSD1 enzyme activity in existing technologies has been solved, providing a highly efficient inhibitor of LSD1 for the development of drugs that target and inhibit LSD1 and anti-gastric cancer drugs.

CN121895296APending Publication Date: 2026-04-21ZHENGZHOU UNIV
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Patent Information

Application Number
CN202610049260.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-01-15
Publication Date
2026-04-21

AI Technical Summary

Technical Problem

Existing technologies are insufficient to effectively inhibit LSD1 enzyme activity, leading to the proliferation and metastasis of gastric cancer cells. There is a lack of drugs with high specificity that target and inhibit LSD1.

Method used

A class of quinoxaline compounds was designed and synthesized. By introducing aromatic rings, aromatic heterocycles, and electron-donating/withdrawing groups at different sites of the quinoxaline parent ring, compounds with good inhibitory activity against LSD1 were formed.

Benefits of technology

Quinoxaline compounds exhibit highly efficient inhibitory activity against LSD1, effectively inhibiting gastric cancer cells and providing a novel structural framework for the development of drugs that target and inhibit LSD1 or anti-gastric cancer drugs.

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Abstract

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a quinoxaline compound and application thereof. The quinoxaline compound provided by the invention is a compound as shown in a formula I or a pharmaceutically acceptable salt thereof. The quinoxaline compound disclosed by the invention is novel in skeleton, and tests prove that the compound has good inhibitory activity on LSD1 and also has relatively good inhibitory activity on gastric cancer cells. Therefore, the quinoxaline compound shows good drug development potential, can provide molecular basis and data support for research and development of drugs for targeted inhibition of LSD1 or anti-gastric cancer drugs, and can also provide potential lead compounds for development of drugs for targeted inhibition of LSD1 and anti-gastric cancer drugs.
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