Bimodal nanoprobe for detecting uric acid and preparation method and application thereof

By designing a core-shell structure for a dual-modal nanoprobe, integrating fluorescence and photothermal signals and combining it with molecularly imprinted polymers, specific recognition and high-sensitivity detection of uric acid are achieved. This solves the problems of poor selectivity and high cost in existing technologies and is suitable for rapid and convenient detection of uric acid.

CN121895950BActive Publication Date: 2026-06-16JILIN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JILIN UNIVERSITY
Filing Date
2026-03-23
Publication Date
2026-06-16

AI Technical Summary

⚠Technical Problem

Existing uric acid detection methods suffer from poor selectivity, cumbersome operation, and high cost, making accurate quantification particularly difficult in complex biological samples.

⚗Method used

Employing a dual-modal nanoprobe, a core-shell structure design integrates a fluorescent core, a photothermal intermediate layer, and a specific recognition layer. By utilizing a combination of carbon dots, molecularly imprinted polymers, and manganese dioxide, dual-modal sensing is achieved, enabling specific recognition of uric acid, fluorescence recovery, and photothermal attenuation.

🎯Benefits of technology

It achieves highly selective and sensitive detection of uric acid, is simple and rapid, suitable for clinical point-of-care testing, low in cost and highly stable, and applicable to the detection of uric acid concentration in serum, urine and synovial fluid.

✦ Generated by Eureka AI based on patent content.

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Abstract

The application relates to the technical field of nanobiosensors, and discloses a bimodal nanoprobe for uric acid detection and a preparation method and application thereof. The bimodal nanoprobe is a fluorescence-photothermal bimodal nanoprobe, and is a core-shell structure nanoparticle, which comprises, from the inner layer to the outer layer, a) a fluorescent inner core composed of carbon dots and a silica layer coated outside the carbon dots; b) a manganese dioxide layer coated outside the fluorescent inner core; and c) a molecularly imprinted polymer layer coated outside the manganese dioxide layer. The bimodal nanoprobe in the application integrates a fluorescence signal source (carbon dots), a signal modulation and photothermal unit and a specific recognition layer (a uric acid molecularly imprinted polymer) through ingenious structure design, realizes bimodal sensing of "specific recognition -> MnO2 etching -> fluorescence recovery / photothermal weakening" on UA, and effectively solves the problems of poor selectivity, complicated operation and high cost of traditional methods.
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