Gynostemma pentaphylla-shiny-leaved yellowhorn tea leaf compound anti-aging health-care product and preparation method thereof

Abstract

The invention discloses a gynostemma pentaphylla-shiny-leaved yellowhorn tea leaf compound health-care product and a preparation method thereof, and belongs to the technical field of health-care products. The health-care product consists of a gynostemma pentaphylla extract and a xanthoceras sorbifolia bunge tea leaf extract in a mass ratio of (1: 1)-(5: 1), preferably 3: 1. The preparation method comprises the following steps: respectively crushing the two raw materials, then adopting a graded extraction process, carrying out reflux extraction on the gynostemma pentaphyllum by using 65-75% ethanol, extracting the shiny-leaved yellowhorn tea by using hot water, respectively carrying out vacuum concentration and drying on the extracting solution, compounding in proportion, and adding pharmaceutic adjuvants to prepare capsules, tablets, granules or tea bags. By optimizing the compounding proportion and the extraction process, the synergistic interaction effect of the two plants is fully exerted, and the product has remarkable antioxidant activity and blood fat regulating function, is good in safety and is suitable for anti-aging and health-care purposes.

Description

Technical Field

[0001] This invention belongs to the field of health product technology, specifically relating to an anti-aging health product made from a compound of Gynostemma pentaphyllum and Xanthoceras sorbifolium tea and its preparation method. Background Technology

[0002] With the accelerating aging of the population and the increasing awareness of health, the market demand for anti-aging health products continues to grow. Plant extracts are attracting attention due to their natural sources and multiple health benefits. Among them, Gynostemma pentaphyllum and Xanthoceras sorbifolium tea, as traditional medicinal plants, have broad application prospects in the health care field.

[0003] Gynostemma pentaphyllum, a herbaceous plant of the Cucurbitaceae family, is traditionally known as "Southern Ginseng" in Chinese medicine. Modern research shows that Gynostemma pentaphyllum is rich in active ingredients such as saponins, flavonoids, and polysaccharides, possessing physiological functions such as anti-oxidation, lipid regulation, and immune enhancement. Currently, there are various health products on the market containing only Gynostemma pentaphyllum, such as Gynostemma pentaphyllum tea and capsules. However, using Gynostemma pentaphyllum alone has significant limitations: firstly, its health benefits are limited, making it difficult to achieve synergistic effects across multiple targets; secondly, some individuals may experience adverse reactions such as gastrointestinal discomfort after taking it; and thirdly, long-term use alone may lead to tolerance to certain components, affecting the sustainability of its health benefits.

[0004] *Xanthoceras sorbifolium* is a woody oilseed plant unique to my country, and its leaves have a long tradition of being used to make tea. In this invention, it is referred to uniformly as *Xanthoceras sorbifolium* tea. Studies have found that *Xanthoceras sorbifolium* tea is rich in polyphenols, flavonoids, and saponins, exhibiting significant antioxidant and anti-inflammatory effects. Currently, *Xanthoceras sorbifolium* tea is mainly used as a single-ingredient tea beverage, with a relatively low level of development and utilization. Using *Xanthoceras sorbifolium* tea alone presents the following problems: firstly, its health benefits are relatively limited, mainly manifested in its antioxidant effects, with insufficient research on other efficacy; secondly, the bioavailability of some active ingredients in *Xanthoceras sorbifolium* tea is low, affecting its efficacy; furthermore, as a regional traditional beverage, its application is limited, failing to fully realize its health benefits.

[0005] While existing technologies exist for health supplements that combine Gynostemma pentaphyllum with other plants, such as products combining Gynostemma pentaphyllum with green tea, these combinations have significant shortcomings: First, the selection of the compounding ingredients lacks sufficient theoretical basis and experimental support, relying mostly on empirical combinations; second, the compounding ratios are not optimized enough, making it difficult to achieve the best synergistic effect; third, existing compound products often ignore the characteristics of different raw materials and adopt a uniform extraction process, leading to the loss or transformation of some active ingredients; finally, the preparation processes of existing products are relatively crude, lacking precise control over key process parameters, affecting the stability and consistency of product quality.

[0006] Therefore, developing a compound health product of Gynostemma pentaphyllum and Xanthoceras sorbifolium tea based on sufficient pharmacological research, with a clear theoretical foundation for compound formulation, using targeted extraction technology, and capable of fully exerting synergistic effects, has important practical application value. Summary of the Invention

[0007] The purpose of this invention is to provide an anti-aging health product made from a compound of Gynostemma pentaphyllum and Xanthoceras sorbifolium tea leaves, and its preparation method.

[0008] To achieve the above objectives, the present invention provides the following technical solution: A compound health product of Gynostemma pentaphyllum and Xanthoceras sorbifolium tea contains Gynostemma pentaphyllum extract and Xanthoceras sorbifolium tea extract, wherein the mass ratio of Gynostemma pentaphyllum extract to Xanthoceras sorbifolium tea extract is 1:1 to 5:1.

[0009] Furthermore, the mass ratio of the Gynostemma pentaphyllum extract to the Xanthoceras sorbifolium tea extract is 3:1.

[0010] Furthermore, the health product also includes pharmaceutically acceptable excipients, which include at least one of starch, dextrin, magnesium stearate, microcrystalline cellulose, sodium carboxymethyl starch, pregelatinized starch, and silicon dioxide.

[0011] Furthermore, the dosage form of the health product is capsules, tablets, granules, or tea bags.

[0012] Furthermore, the content of gypenosides in the gypenosus extract is ≥78mg / g, and the content of polyphenols in the saxifrage tea extract is ≥48mg / g.

[0013] A method for preparing a compound health product of Gynostemma pentaphyllum and Xanthoceras sorbifolium tea includes the following steps: Step 1, Raw material processing: Gynostemma pentaphyllum and Sapindus mukorossi tea leaves are crushed and passed through a 60-80 mesh sieve respectively; Step 2, Hierarchical Extraction: Step 2a, Gynostemma pentaphyllum extraction: The pulverized Gynostemma pentaphyllum is extracted by reflux with an ethanol solution of 65%-75% (v / v), the material-to-liquid ratio is 1:12-1:18, the extraction temperature is 75-85℃, and the extraction is performed twice, each time for 1.5-2.5 hours. The extracts are combined, filtered, and the Gynostemma pentaphyllum extract is obtained. Step 2b, Extraction of Xanthoceras sorbifolium tea leaves: The crushed Xanthoceras sorbifolium tea leaves are extracted with hot water at a ratio of 1:15 to 1:25 and an extraction temperature of 85-95℃. The extraction is repeated 3 times, each time for 0.5-1.5 hours. The extracts are combined, filtered, and Xanthoceras sorbifolium tea leaf extract is obtained. Step 3, Concentration and Drying: Step 3a: Concentrate the Gynostemma pentaphyllum extract under reduced pressure at 60-65℃ to a relative density of 1.12-1.18 (measured at 50℃), and then spray dry it with an inlet air temperature of 165-175℃ and an outlet air temperature of 75-85℃ to obtain Gynostemma pentaphyllum extract. Step 3b: Concentrate the *Xanthoceras sorbifolium* tea extract under reduced pressure at 55-60℃ to a relative density of 1.08-1.15 (measured at 50℃), and then vacuum dry it at a temperature of 60-70℃ and a vacuum degree of -0.08~-0.10MPa to obtain *Xanthoceras sorbifolium* tea extract. Step 4, Compounding and Formulation: The Gynostemma pentaphyllum extract and Xanthoceras sorbifolium tea extract are mixed according to the mass ratio described in claim 1 or 2, and pharmaceutically acceptable excipients are added to prepare the desired dosage form.

[0014] Furthermore, in step 2a, the volume concentration of the ethanol solution is 70%, and the material-to-liquid ratio is 1:15.

[0015] Furthermore, in step 2b, the temperature of the hot water is 90°C, and the material-to-liquid ratio is 1:20.

[0016] Furthermore, in step 3a, the inlet air temperature of the spray drying is 170°C and the outlet air temperature is 80°C; in step 3b, the temperature of the vacuum drying is 65°C.

[0017] Beneficial effects: This invention achieves significantly better technical effects than using single ingredients by compounding Gynostemma pentaphyllum extract and Xanthoceras sorbifolium tea extract in a specific ratio and employing a targeted graded extraction process. 1. Significantly improved extraction efficiency of active ingredients By employing a graded extraction process, and targeting the physicochemical properties of the main active ingredients in Gynostemma pentaphyllum and Xanthoceras sorbifolium tea leaves, optimized ethanol reflux extraction and hot water extraction processes were used respectively. This resulted in an extraction rate of over 85% for Gynostemma pentaphyllum saponins and over 78% for Xanthoceras sorbifolium tea polyphenols, which are significantly higher than the extraction efficiency of traditional mixed extraction processes (approximately 60-70%).

[0018] 2. Synergistic enhancement of antioxidant activity Experimental results showed that, at the optimal compound ratio (3:1), the compound extract achieved a DPPH free radical scavenging rate of 85.2%, which was 30.5% and 54.6% higher than that of single Gynostemma pentaphyllum extract (65.3%) and single Xanthoceras sorbifolium tea extract (55.1%), respectively. Simultaneously, the compound increased SOD activity by 42.8%, GSH-Px activity by 35.6%, and decreased MDA content by 39.2% in mouse liver tissue, demonstrating a significant synergistic antioxidant effect.

[0019] 3. More comprehensive blood lipid regulation effect In experiments on rats with hyperlipidemia, the compound health supplement showed the best lipid-regulating effect when the mass ratio was 3:1. Serum total cholesterol (TC) decreased by 24.7%, triglycerides (TG) decreased by 29.8%, low-density lipoprotein cholesterol (LDL-C) decreased by 32.5%, while high-density lipoprotein cholesterol (HDL-C) increased by 18.3%. Its comprehensive lipid-regulating effect was significantly better than the simple superposition of single ingredients.

[0020] 4. Bioavailability is effectively improved In vitro simulated digestion experiments showed that the bioavailability of the main active ingredients (Gynostemma pentaphyllum saponins and Xanthoceras sorbifolium polyphenols) in the compound extract reached 71.3% and 68.9%, respectively, which was 15-20% higher than that of the single extract. This may be because the different components in the two extracts form a complex during digestion, which slows down the degradation and transformation of the active ingredients.

[0021] 5. Product stability has been significantly improved. Accelerated stability testing (40℃±2℃, RH 75%±5%) showed that the retention rate of the main active ingredients in the compound health supplement was over 90% after 6 months, and all physicochemical indicators met the quality standard requirements, demonstrating good storage stability. This is attributed to the protective effect of the graded extraction process on heat-sensitive components and the mutual stabilizing effect of the compound system.

[0022] 6. Safety is guaranteed Acute toxicity tests showed that the maximum tolerated dose (MTD) of the compound health supplement was greater than 10.0 g / kg body weight, classifying it as practically non-toxic. In long-term toxicity tests, no significant adverse reactions were observed in experimental animals at any dosage group, indicating that the compound health supplement is safe and reliable when used at the recommended dosage.

[0023] 7. The process has good reproducibility and is easy to industrialize. The preparation method provided by this invention has precisely optimized and controlled each key process parameter, resulting in stable product quality between different batches. The relative standard deviation (RSD) of the content of the main active ingredients is less than 5%, demonstrating good process reproducibility and making it suitable for large-scale production.

[0024] The above-mentioned beneficial effects have all been verified through standardized experimental studies, demonstrating the significant progress of this invention compared to existing technologies, and providing a new technical solution for developing efficient and safe anti-aging health products. Attached Figure Description

[0025] Figure 1 This is a process flow diagram for preparing a health product made from a compound of Gynostemma pentaphyllum and Xanthoceras sorbifolium tea leaves. Detailed Implementation

[0026] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention. Example 1

[0027] Raw material preparation: Gynostemma pentaphyllum: The five-year-old Gynostemma pentaphyllum was harvested from Pingli County, Shaanxi Province. The dried whole herb was taken, with a moisture content of ≤8%. The initial content of Gynostemma pentaphyllum saponins was tested to be 102 mg / g.

[0028] Xanthoceras sorbifolium tea leaves: harvested from the leaves of three-year-old Xanthoceras sorbifolium trees in Chifeng City, Inner Mongolia. Whole leaves are used, with a moisture content of ≤10%. The initial polyphenol content of Xanthoceras sorbifolium was tested to be 82mg / g.

[0029] Preparation process: (see) Figure 1 ) Step 1, Raw material processing: Gynostemma pentaphyllum and Sapindus mukorossi tea leaves are pulverized separately using a universal pulverizer and passed through a 60-mesh sieve to obtain uniform raw material powder.

[0030] Step 2, Hierarchical Extraction: Step 2a, Gynostemma pentaphyllum extraction: Accurately weigh 1.5 kg of Gynostemma pentaphyllum powder and place it in a 50 L extraction tank. Add 22.5 L of 70% ethanol solution (solid-to-liquid ratio 1:15) and reflux extract twice at 80 °C, 2 hours each time. Combine the two extracts and filter them using a plate and frame filter press to obtain a clear Gynostemma pentaphyllum extract.

[0031] Step 2b: Extraction of Xanthoceras sorbifolium tea leaves: Accurately weigh 0.5 kg of Xanthoceras sorbifolium tea leaf powder and place it in a 20 L extraction tank. Add 10 L of purified water (solid-to-liquid ratio 1:20) and extract three times at 90 °C, one hour each time. Combine the three extracts and filter through a 200-mesh filter cloth to obtain Xanthoceras sorbifolium tea leaf extract.

[0032] Step 3, Concentration and Drying: Step 3a: Transfer the Gynostemma pentaphyllum extract to a vacuum concentrator and concentrate it under reduced pressure at 62°C until the relative density reaches 1.15 (measured at 50°C), obtaining a concentrated paste. Spray dry the concentrated paste, setting the inlet air temperature to 170°C and the outlet air temperature to 80°C, to obtain a light yellow Gynostemma pentaphyllum extract powder with a yield of 18.2%. The content of Gynostemma pentaphyllum saponins was determined to be 85.6 mg / g.

[0033] Step 3b: The *Xanthoceras sorbifolium* tea extract was concentrated under reduced pressure at 58°C to a relative density of 1.12 (measured at 50°C), then transferred to a vacuum drying oven and dried to constant weight at 65°C and a vacuum of -0.09 MPa to obtain a brownish-red *Xanthoceras sorbifolium* tea extract powder with a yield of 22.5%. The polyphenol content of *Xanthoceras sorbifolium* was found to be 62.3 mg / g.

[0034] Step 4, Compounding and Molding: Weigh 270g of Gynostemma pentaphyllum extract and 90g of Xanthoceras sorbifolium tea extract at a mass ratio of 3:1 and mix well. Add 40g of microcrystalline cellulose, 20g of sodium carboxymethyl starch and 2g of magnesium stearate, granulate using a wet granulation process, and compress into 1000 tablets using a rotary tablet press. Each tablet weighs 0.422g and contains 0.36g of extract. Example 2

[0035] Preparation process: Step 1, Raw material processing: Same as in Example 1, the raw materials are crushed and passed through an 80-mesh sieve, the initial content of Gynostemma pentaphyllum saponins is 100mg / g, and the initial content of Xanthoceras sorbifolium polyphenols is 80mg / g.

[0036] Step 2, Hierarchical Extraction: Step 2a, Gynostemma pentaphyllum extraction: Take 2 kg of Gynostemma pentaphyllum powder, add 30 L of 65% ethanol solution (solid-liquid ratio 1:15), and reflux extract twice at 75℃, each time for 2.5 hours.

[0037] Step 2b, Extraction of *Xanthoceras sorbifolium* tea leaves: Take 1 kg of *Xanthoceras sorbifolium* tea leaf powder, add 20 L of purified water (material-to-liquid ratio 1:20), and extract 3 times at 85℃, 1.5 hours each time.

[0038] Step 3, Concentration and Drying: Step 3a: The Gynostemma pentaphyllum extract was concentrated under reduced pressure at 60℃ to a relative density of 1.12, and spray-dried at an inlet air temperature of 165℃ and an outlet air temperature of 75℃, resulting in a Gynostemma pentaphyllum saponin content of 82.4 mg / g.

[0039] Step 3b: The extract of *Sapindus mukorossi* tea leaves was concentrated under reduced pressure at 55℃ to a relative density of 1.08, and then vacuum dried at 60℃ with a vacuum degree of -0.08MPa. The polyphenol content of *Sapindus mukorossi* was 65.1mg / g.

[0040] Step 4, Compounding and Molding: Weigh 200g of Gynostemma pentaphyllum extract and 100g of Xanthoceras sorbifolium tea extract at a mass ratio of 2:1, add 30g of pregelatinized starch and 10g of silicon dioxide, and fill 1000 No. 0 capsules, each containing 0.33g of extract. Example 3

[0041] Preparation process: Step 1, Raw material processing: Same as in Example 1, with an initial content of 98 mg / g of Gynostemma pentaphyllum saponins and an initial content of 78 mg / g of Xanthoceras sorbifolium polyphenols.

[0042] Step 2, Hierarchical Extraction: Step 2a, Gynostemma pentaphyllum extraction: Take 1 kg of Gynostemma pentaphyllum powder, add 18 L of 75% ethanol solution (solid-liquid ratio 1:18), and reflux extract twice at 85℃, each time for 1.5 hours.

[0043] Step 2b, Extraction of *Xanthoceras sorbifolium* tea leaves: Take 1 kg of *Xanthoceras sorbifolium* tea leaf powder, add 15 L of purified water (material-to-liquid ratio 1:15), and extract 3 times at 95℃, each time for 0.5 hours.

[0044] Step 3, Concentration and Drying: Step 3a: The Gynostemma pentaphyllum extract was concentrated under reduced pressure at 65℃ to a relative density of 1.18, and spray-dried at an inlet air temperature of 175℃ and an outlet air temperature of 85℃, resulting in a Gynostemma pentaphyllum saponin content of 78.9 mg / g.

[0045] Step 3b: The extract of *Sapindus mukorossi* tea leaves was concentrated under reduced pressure at 60℃ to a relative density of 1.15, and then vacuum dried at 70℃ with a vacuum degree of -0.10MPa. The polyphenol content of *Sapindus mukorossi* was 68.7mg / g.

[0046] Step 4, Compounding and Molding: Weigh 150g of Gynostemma pentaphyllum extract and 150g of Xanthoceras sorbifolium tea extract at a mass ratio of 1:1, add 50g of dextrin and 10g of microcrystalline cellulose, granulate by wet method, and then package into 1000 sachets, each sachet containing 0.31g of extract.

[0047] Comparative Example 1 Following the preparation method of Gynostemma pentaphyllum extract in Example 1, 360g of Gynostemma pentaphyllum extract powder with a Gynostemma pentaphyllum saponin content of 92.5mg / g was obtained. The same excipients were added and the powder was compressed into 1000 tablets, each containing 0.36g of Gynostemma pentaphyllum extract.

[0048] Comparative Example 2 Following the preparation method of *Vernicia fordii* tea extract in Example 1, 360g of *Vernicia fordii* tea extract powder was prepared, with a *Vernicia fordii* polyphenol content of 75.8mg / g. The same excipients were added, and the powder was compressed into 1000 tablets, each containing 0.36g of *Vernicia fordii* tea extract.

[0049] Comparative Example 3 1.5 kg of Gynostemma pentaphyllum powder and 0.5 kg of Xanthoceras sorbifolium tea powder were mixed and added to 30 L of 70% ethanol solution. The mixture was refluxed twice at 80 °C for 2 hours each time. The extracts were combined and concentrated under reduced pressure at 62 °C to a relative density of 1.15 (measured at 50 °C). The mixture was then spray-dried (inlet air 170 °C, outlet air 80 °C) to obtain a mixed extract. The same excipients (40 g microcrystalline cellulose, 20 g sodium carboxymethyl starch, 2 g magnesium stearate) were added, and the mixture was compressed into 1000 tablets. Analysis showed that the mixed extract contained 71.2 mg / g of Gynostemma pentaphyllum saponins and 53.6 mg / g of Xanthoceras sorbifolium polyphenols.

[0050] Comparative Example 4 The preparation method of Example 1 was followed, but the mass ratio of Gynostemma pentaphyllum extract to Xanthoceras sorbifolium tea extract was changed to 6:1, while other process parameters remained the same. Testing revealed that the product contained 89.7 mg / g of Gynostemma pentaphyllum saponins and 45.2 mg / g of Xanthoceras sorbifolium polyphenols.

[0051] Comparative Example 5 The raw material ratio of Example 1 is followed, but the following non-preferred process parameters are used: Gynostemma pentaphyllum extraction: Use 50% ethanol, with a solid-liquid ratio of 1:8, an extraction temperature of 65℃, and extract once; Extraction of *Sapindus mukorossi* tea leaves: Use 70℃ hot water, material-to-liquid ratio 1:10, extraction temperature 70℃, extraction twice; The concentration temperature is uniformly set at 70℃; Drying was performed using a standard oven at 80℃. Testing revealed that the product contained 68.4 mg / g of Gynostemma pentaphyllum saponins and 48.9 mg / g of Xanthoceras sorbifolium polyphenols.

[0052] Product performance testing 1. Determination of active ingredient content The contents of Gynostemma pentaphyllum saponins and Xanthoceras sorbifolium polyphenols in the products of each example and comparative example were determined by high performance liquid chromatography. The results are shown in Table 1.

[0053] Table 1: Comparison of active ingredient content in each example and comparative example

[0054] Note: The extraction rate is calculated as (mass of extract × content of active ingredient in extract) / (mass of raw material × initial content of active ingredient in raw material) × 100%.

[0055] 2. Antioxidant activity assay The IC50 values ​​of each product were determined using the DPPH free radical scavenging experiment, and the results are shown in Table 2.

[0056] Table 2: Comparison of DPPH free radical scavenging activities among the examples and comparative examples

[0057] 3. Lipid-regulating function experiment Healthy SD rats, half male and half female, weighing 180-220g, were selected. Except for the normal control group, all other groups were fed a high-fat diet to establish a hyperlipidemia model. After successful model establishment, the products of each example and comparative example were administered by gavage at a dose of 360mg / kg for 30 consecutive days. Serum lipid levels were measured at the end of the experiment, and the results are shown in Table 3.

[0058] Table 3: Comparison of lipid-regulating effects of various examples and comparative examples (x±s, n=10)

[0059] Note: Compared with the model control group, *P<0.05, **P<0.01 4. Stability test The product of Example 1 was placed under accelerated testing conditions (40℃±2℃, RH75%±5%) for 6 months, and samples were taken and tested at 0, 1, 2, 3 and 6 months respectively. The results are shown in Table 4.

[0060] Table 4: Results of Product Stability Test in Example 1

[0061] The above experimental results show that the Gynostemma pentaphyllum-Sapindus mukorossi tea compound health product provided by this invention is significantly superior to single-component products and products prepared by non-optimal processes in terms of active ingredient content, antioxidant activity, and lipid-regulating function, and also exhibits good stability. In particular, the product of Example 1, which uses a graded extraction process and optimized ratio, demonstrates the best overall performance.

[0062] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention. Equivalent substitutions or improvements made by those skilled in the art based on the solutions described in the present invention should be included within the scope of protection of the present invention.

Claims

1. A health supplement made from a compound of Gynostemma pentaphyllum and Xanthoceras sorbifolium tea leaves, characterized in that, It contains Gynostemma pentaphyllum extract and Xanthoceras sorbifolium tea extract, wherein the mass ratio of Gynostemma pentaphyllum extract to Xanthoceras sorbifolium tea extract is 1:1 to 5:1; the Gynostemma pentaphyllum extract is prepared by reflux extraction with 65%-75% ethanol by volume concentration, and the Xanthoceras sorbifolium tea extract is prepared by hot water extraction.

2. The health product made from Gynostemma pentaphyllum and Xanthoceras sorbifolium tea according to claim 1, characterized in that, The mass ratio of the Gynostemma pentaphyllum extract to the Xanthoceras sorbifolium tea extract is 3:

1.

3. The health product made from Gynostemma pentaphyllum and Xanthoceras sorbifolium tea according to claim 1 or 2, characterized in that, The health product also includes pharmaceutically acceptable excipients, which include at least one of starch, dextrin, magnesium stearate, microcrystalline cellulose, sodium carboxymethyl starch, pregelatinized starch, and silicon dioxide.

4. The health product made from Gynostemma pentaphyllum and Xanthoceras sorbifolium tea according to claim 1 or 2, characterized in that, The health products are available in capsule, tablet, granule, or tea bag form.

5. A method for preparing a compound health product of Gynostemma pentaphyllum and Xanthoceras sorbifolium tea as described in any one of claims 1-4, characterized in that, Includes the following steps: Step 1, Raw material processing: Gynostemma pentaphyllum and Sapindus mukorossi tea leaves are crushed and passed through a 60-80 mesh sieve respectively; Step 2, Hierarchical Extraction: Step 2a, Gynostemma pentaphyllum extraction: The pulverized Gynostemma pentaphyllum is extracted by reflux with an ethanol solution of 65%-75% (v / v), the material-to-liquid ratio is 1:12-1:18, the extraction temperature is 75-85℃, and the extraction is performed twice, each time for 1.5-2.5 hours. The extracts are combined, filtered, and the Gynostemma pentaphyllum extract is obtained. Step 2b, Extraction of Xanthoceras sorbifolium tea leaves: The crushed Xanthoceras sorbifolium tea leaves are extracted with hot water at a ratio of 1:15 to 1:25 and an extraction temperature of 85-95℃. The extraction is repeated 3 times, each time for 0.5-1.5 hours. The extracts are combined, filtered, and Xanthoceras sorbifolium tea leaf extract is obtained. Step 3, Concentration and Drying: Step 3a: Concentrate the Gynostemma pentaphyllum extract under reduced pressure at 60-65°C to a relative density of 1.12-1.18, and then spray dry it with an inlet air temperature of 165-175°C and an outlet air temperature of 75-85°C to obtain Gynostemma pentaphyllum extract. Step 3b: Concentrate the *Xanthoceras sorbifolium* tea extract under reduced pressure at 55-60℃ to a relative density of 1.08-1.15, and then vacuum dry it at a temperature of 60-70℃ and a vacuum degree of -0.08~-0.10MPa to obtain *Xanthoceras sorbifolium* tea extract. Step 4, Compounding and Formulation: The Gynostemma pentaphyllum extract and Xanthoceras sorbifolium tea extract are mixed according to the mass ratio described in claim 1 or 2, and pharmaceutically acceptable excipients are added to prepare the desired dosage form.

6. The preparation method of the Gynostemma pentaphyllum-Sapindus mukorossi tea compound health product according to claim 5, characterized in that, In step 2a, the volume concentration of the ethanol solution is 70%, and the material-to-liquid ratio is 1:

15.

7. The preparation method of the Gynostemma pentaphyllum-Sapindus mukorossi tea compound health product according to claim 5, characterized in that, In step 2b, the temperature of the hot water is 90°C and the material-to-liquid ratio is 1:

20.

8. The preparation method of the Gynostemma pentaphyllum-Sapindus mukorossi tea compound health product according to claim 5, characterized in that, In step 3a, the inlet air temperature of the spray drying is 170°C and the outlet air temperature is 80°C; in step 3b, the temperature of the vacuum drying is 65°C.

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