Liquid composition and electronic cigarette

Abstract

The purpose of the present invention is to provide a liquid composition and the like having an excellent pressure-reducing effect. The present invention relates to a liquid composition containing an organic solvent and beta-caryophyllene, the content of the beta-caryophyllene being 0.5-10.0 mass% with respect to the total amount of the liquid composition.

Description

Technical Field

[0001] This invention relates to a liquid composition and an electronic cigarette. Background Technology

[0002] As alternatives to traditional combustible cigarettes, the research and development and practical application of electronic cigarettes such as heated cigarettes and vaporizers (VAPE) are progressing. For example, Patent Document 1 discloses an aerosol-generating article comprising an aerosol-generating matrix, wherein the aerosol-generating matrix contains homogenized plant material including clove particles, and the aerosol-generating matrix contains specific amounts of eugenol, eugenol acetate, and β-caryophyllene.

[0003] Existing technical documents

[0004] Patent documents

[0005] Patent Document 1: Japanese Patent Publication No. 2022-502013 Summary of the Invention

[0006] Technical issues

[0007] However, even if a user inhales the aerosol generated by the aerosol described in Patent Document 1, there is no pressure relief effect or the pressure relief effect is insufficient.

[0008] The present invention was made in view of the above-mentioned problems, and its object is to provide a liquid composition with excellent pressure relief effect.

[0009] Solution to the problem

[0010] To address the aforementioned issues, the inventors conducted repeated and in-depth research, and as a result discovered, a liquid composition can solve these issues. This liquid composition comprises an organic solvent and β-caryophyllene, wherein the content of β-caryophyllene is adjusted to a specific amount relative to the total amount of the liquid composition, thus completing the present invention. That is, the present invention is as follows. [1]

[0012] A liquid composition comprising an organic solvent and β-caryophyllene,

[0013] The content of β-caryophyllene is 0.5 to 10.0% by mass relative to the total amount of the liquid composition. [2]

[0015] The liquid composition according to [1] further comprises a fragrance.

[0016] The content of the fragrance is 0.5 to 10.0% by mass relative to the total amount of the liquid composition. [3]

[0018] According to the liquid composition described in [1] or [2], wherein,

[0019] The content of β-caryophyllene is 1.0 to 5.0% by mass relative to the total amount of the liquid composition. [4]

[0021] The liquid composition according to any one of [1] to [3], wherein,

[0022] The organic solvent comprises glycerol and propylene glycol.

[0023] The content of glycerol W relative to the total amount of the liquid composition. g It ranges from 40.0% to 70.0% by mass.

[0024] The content of propylene glycol W relative to the total amount of the liquid composition p It ranges from 25.0% to 55.0% by mass.

[0025] The glycerol content W g The content of propylene glycol W p The ratio (W) g / W p The value ranges from 0.7 to 3.0. [5]

[0027] The liquid composition according to any one of [1] to [4], wherein,

[0028] The boiling point of the liquid composition is 90–210 °C. [6]

[0030] The liquid composition according to any one of [1] to [5], wherein,

[0031] The liquid composition is substantially nicotine-free. [7]

[0033] The liquid composition according to any one of [1] to [6], wherein,

[0034] The liquid composition does not contain cannabidiol. [8]

[0036] According to the liquid composition described in [1] to [7], wherein,

[0037] The liquid composition is used in electronic cigarettes. [9]

[0039] A liquid e-cigarette cartridge, wherein the cartridge is filled with any one of the liquid compositions described in [1] to [8].

[10]

[0041] An electronic cigarette having the liquid cartridge described in [9].

[0042] Invention Effects

[0043] According to the present invention, liquid compositions and the like with excellent pressure relief effects can be provided. Attached Figure Description

[0044] Figure 1 This is a diagram showing an example of the cross-sectional structure of an electronic cigarette. Detailed Implementation

[0045] Hereinafter, embodiments of the present invention (hereinafter referred to as "this embodiment") will be described in detail with reference to the accompanying drawings, as needed. However, the present invention is not limited thereto, and various modifications can be made without departing from its spirit. Furthermore, in the accompanying drawings, the same elements are labeled with the same reference numerals, and repeated descriptions are omitted. In addition, unless otherwise specified, the positional relationships such as up, down, left, and right are based on the positional relationships shown in the accompanying drawings. Moreover, the scale of the accompanying drawings is not limited to the scale shown in the drawings.

[0046] 1. Liquid composition

[0047] The liquid composition of this embodiment (hereinafter also simply referred to as the "liquid composition") contains an organic solvent and β-caryophyllene, and the content of the β-caryophyllene is 0.5 to 10.0% by mass relative to the total amount of the liquid composition.

[0048] The liquid composition of this embodiment exerts a pressure-reducing effect by comprising an organic solvent and β-caryophyllene, wherein the content of β-caryophyllene is 0.5 to 10.0% by mass relative to the total amount of the liquid composition. When the content of β-caryophyllene exceeds 10.0% by mass relative to the total amount of the liquid composition, not only does it exert a pressure-reducing effect, but it can also produce other negative side effects such as stimulating effects. Furthermore, when the content of β-caryophyllene is less than 0.5% by mass relative to the total amount of the liquid composition, no pressure-reducing effect is produced, or the degree of this effect is very low. On the other hand, it is believed that by maintaining β-caryophyllene within an appropriate concentration range, the pressure-reducing effect of β-caryophyllene is appropriately exerted.

[0049] The boiling point of the liquid composition in this embodiment is preferably 90–210°C, more preferably 100–200°C, and even more preferably 110–190°C. Because the boiling point of the liquid composition is within the above range, when the liquid composition is applied to an electronic cigarette, a suitable amount of vapor can be generated at an appropriate temperature, tending to further improve the pressure relief effect while reducing power consumption.

[0050] The liquid composition of this embodiment is preferably used in electronic cigarettes. In this embodiment, "electronic cigarette" refers to any cigarette other than conventional combustible cigarettes, and is not particularly limited, including, for example, heated cigarettes, vapor cigarettes, electronic hookahs, electronic pipes, etc. In this embodiment, a combustible cigarette refers to a cigarette that produces smoke by burning tobacco leaves or the like. Furthermore, in this embodiment, a heated cigarette refers to a cigarette that produces vapor by heating tobacco leaves or the like with electricity. Additionally, vapor cigarettes refer to cigarettes that produce vapor by heating a liquid substance with electricity at room temperature (25°C) and one atmosphere of pressure.

[0051] Hereinafter, each component of the liquid composition of this embodiment will be described in detail.

[0052] 1.1 Organic solvents

[0053] The liquid composition of this embodiment contains an organic solvent. Preferably, the organic solvent is one with low toxicity to humans, and more preferably, glycerol or propylene glycol.

[0054] When the liquid composition of this embodiment contains glycerol as an organic solvent, the content of glycerol is preferably 40.0 to 70.0% by mass, more preferably 42.5 to 67.5% by mass, and even more preferably 45.0 to 65.0% by mass, relative to the total amount of the liquid composition.

[0055] When the liquid composition of this embodiment contains propylene glycol as an organic solvent, the content of propylene glycol relative to the total amount of the liquid composition is preferably 25.0 to 55.0% by mass, more preferably 27.5 to 52.5% by mass, and even more preferably 30.0 to 50.0% by mass.

[0056] In this embodiment, when the liquid composition contains glycerol and propylene glycol as organic solvents, the glycerol content W g With propylene glycol content W p The ratio (W) g / W p The preferred value is 0.7–3.0, more preferably 0.8–2.5, further preferably 0.9–2.0, even more preferably 1.0–1.9, and particularly preferably 1.1–1.7. (Through W) g / W p Within the aforementioned range, the viscosity of the liquid composition becomes suitable, and when the liquid composition is applied to an electronic cigarette, the rate at which the liquid is supplied to the atomizer (spray device) tends to become appropriate.

[0057] 1.2, β-Caryophyllene

[0058] The liquid composition of this embodiment contains β-caryophyllene. The content of β-caryophyllene is 0.5 to 10.0% by mass relative to the total amount of the liquid composition. Furthermore, the content of β-caryophyllene is preferably 0.7 to 7.5% by mass, more preferably 1.0 to 5.0% by mass, and even more preferably 1.5 to 4.5% by mass relative to the total amount of the liquid composition. By having the content of β-caryophyllene within the above range, the pressure-reducing effect of β-caryophyllene tends to be appropriately exerted.

[0059] 1.3 Spices

[0060] The liquid composition of this embodiment may also contain fragrance. Furthermore, in this embodiment, β-caryophyllene is not included in the fragrance. As a fragrance, suitable substances can be used to impart the desired aroma, and commercially available fragrances can be used. More specifically, examples include: fruit fragrances such as apple flavoring and lemon flavoring, or peppermint flavoring, but there are no particular limitations. Examples of such fragrances include: acetates such as isoamyl acetate, ethyl acetate, cis-3-hexenyl acetate, and geraniol acetate; butyrates such as ethyl 2-methylbutyrate and isoamyl butyrate; monoterpenes such as linalool, cis-linalool oxide, and nerol; vanillin and ethyl vanillin; lactones such as γ-octyl lactone; maltol and ethyl maltol; methyl dihydrojasmonate; cycloene; cis-3-hexenol; (R)-(-)-carboxylic acid, but there are no particular limitations.

[0061] There is no particular limitation on the content of the fragrance. For example, the content of the fragrance is 0.5 to 10.0% by mass, 1.0 to 8.0% by mass, 1.5 to 8.0% by mass, and 2.5 to 7.5% by mass relative to the total amount of the liquid composition.

[0062] 1.4 Water

[0063] The liquid composition of this embodiment may or may not contain water. When the liquid composition contains water, there is no particular limitation on the water content. For example, the water content relative to the total amount of the liquid composition is 5.0 to 50.0% by mass, 10.0 to 45.0% by mass, and 15.0 to 40.0% by mass.

[0064] 1.5 Other additives

[0065] The liquid composition of this embodiment may also contain other additives besides the components described above. There are no particular limitations on other additives, but examples include: sweeteners, natural flavorings, artificial flavorings, colorings, antioxidants, preservatives, chelating agents, viscosity modifiers, isotonic agents, odorants, emulsifiers, suspending agents, binders, thickeners, carriers, and mixtures thereof.

[0066] The liquid composition of this embodiment may also contain nicotine as other additives, but preferably is substantially nicotine-free, more preferably completely nicotine-free. "Substantially nicotine-free" means, for example, that the nicotine content relative to the total amount of the liquid composition is 0–2.0% by mass, 0–1.5% by mass, 0–1.0% by mass, 0–0.5% by mass, or 0–0.1% by mass, but is not particularly limited.

[0067] The liquid composition of this embodiment preferably does not contain cannabidiol as other additives.

[0068] The liquid composition of this embodiment may also contain l-menthol as another additive. When l-menthol is included, the content of l-menthol is preferably 1.0 to 15.0% by mass and 2.5 to 10.0% by mass relative to the total amount of the liquid composition. With the content of l-menthol within the above range, there is a tendency to increase the stimulating sensation (also known as the impact sensation) felt when inhaling conventional burning cigarettes containing nicotine.

[0069] This invention also provides the following:

[0070] A method for relieving pressure includes: administering the liquid composition of the present invention;

[0071] The liquid composition of the present invention is used to relieve pressure;

[0072] The β-caryophyllene of the present invention is used to relieve pressure.

[0073] The use of β-caryophyllene of the present invention in the preparation of the liquid composition of the present invention.

[0074] Here, the liquid composition of the present invention can be any of the above-described embodiments.

[0075] 2. Preparation method of liquid composition

[0076] There are no particular limitations on the preparation method of the liquid composition of this embodiment. For example, the above-mentioned components can be mixed. More specifically, the above-mentioned components can be added to the above-mentioned organic solvent in sequence and then mixed. Alternatively, fragrances and other additives can be mixed in the above-mentioned organic solvent to form a mixture, and then the mixture can be mixed with β-caryophyllene.

[0077] 3. Instructions for use of the liquid composition

[0078] As a method of using the liquid composition in this embodiment, it is preferable to inhale the liquid composition after heating it to vaporize it. More specifically, examples include: inhaling the liquid composition after vaporizing it by bathing it in hot water, or applying it to electronic cigarettes, but there are no particular limitations. Among these, the method of applying it to electronic cigarettes is preferred.

[0079] 3.1 Electronic cigarettes

[0080] The liquid composition of this embodiment is suitable for use in electronic cigarettes. The liquid composition of this embodiment is preferably filled in a liquid cartridge, and the electronic cigarette preferably includes a liquid cartridge filled with the liquid composition of this embodiment. Figure 1 This is a diagram showing an example of the cross-sectional structure of an electronic cigarette.

[0081] The electronic cigarette 200 of this embodiment includes an insertion portion 210 for inserting a liquid cartridge 100 filled with a liquid composition into the electronic cigarette 200. The liquid cartridge 100 includes: a mouthpiece 110 for inhaling vapor generated by heating the liquid composition within the liquid cartridge 100; a support portion 120 for supporting the mouthpiece 110 and the atomizer 130; and an atomizer 130 for heating the liquid composition within the liquid cartridge 100 to vaporize it. Furthermore, the area around the insertion portion 210 of the electronic cigarette 200 can be filled with a suitable material such as resin, or it can be at least partially hollow.

[0082] The electronic cigarette 200 includes a battery for powering the atomizer 130. Power is supplied to the atomizer 130 from the battery via the contact portion between the insertion part 210 and the atomizer 130, but this is not particularly limited. The atomizer 130 heats up using the supplied electricity, vaporizing the liquid composition drawn into the liquid cartridge 100, and then delivering the vapor to the mouthpiece 110. The vaporized liquid composition can then be inhaled through the mouthpiece 110. The temperature at which the atomizer 130 heats the liquid composition is not particularly limited, but is, for example, 80–110°C.

[0083] Example

[0084] The present invention will now be described in more detail using examples and comparative examples. The present invention is not limited to any of the examples described below. Furthermore, unless otherwise specified, all experiments were conducted at room temperature (25°C) and one atmosphere.

[0085] 1. Preparation of liquid compositions

[0086] 53 parts by weight of glycerin, 39 parts by weight of propylene glycol, and 5 parts by weight of apple flavoring were mixed to prepare mixture 1. Then, 3 parts by weight of β-caryophyllene were mixed into 97 parts by weight of mixture 1 to prepare liquid composition 1.

[0087] Furthermore, liquid compositions 2 to 10 were obtained by mixing the components in the amounts shown in Table 1 below. The values ​​listed in Table 1 represent the content, expressed as a percentage of mass relative to the total amount of each liquid composition. Table 2 shows the types of fragrances perceived when inhaling liquid compositions 2 to 10.

[0088] [Table 1]

[0089]

[0090] The CAS numbers of the compounds contained in liquid compositions 2 to 10 are as follows.

[0091] L-Menthol: 2216-51-5

[0092] Vanillin: 121-33-5

[0093] Ethyl vanillin: 121-32-4

[0094] Linalool: 78-70-6

[0095] Nerol: 106-25-2

[0096] 2-Methylbutyrate: 7452-79-1

[0097] Methyl dihydrojasmonic acid (cis-trans-mixture): 24851-98-7

[0098] Maltol: 118-71-8

[0099] Ethyl maltol: 4940-11-8

[0100] Cycloenes: 80-71-7

[0101] γ-Octinolone: ​​104-50-7

[0102] Ethyl acetate: 141-78-6

[0103] Isoamyl butyrate: 106-27-4

[0104] Isoamyl acetate: 123-92-2

[0105] cis-Linol oxide: 5989-33-3

[0106] cis-3-hexenyl acetate: 3681-71-8

[0107] Geranyl acetate: 105-87-3

[0108] cis-3-hexenol: 928-96-1

[0109] (R)-(-)-carboxylic acid: 6485-40-1

[0110] β-Caryophyllene: 87-44-5

[0111] Glycerin: 56-81-5

[0112] Propylene glycol: 57-55-6

[0113] [Table 2]

[0114]

[0115] 2. Evaluation

[0116] Three female or male subjects, A to C, aged 20 to 49, were evaluated for their experience before and after inhaling the liquid composition 1 prepared as described above. Specifically, the inhalation of liquid composition 1 was performed as follows.

[0117] First, liquid composition 1 was filled into a liquid cartridge. Then, the cartridge was inserted into a Rockwell DR.VAPE electronic cigarette, vaporizing the liquid composition 1 and inhaling it. Each subject inhaled five times consecutively as one unit, administering at least four units per day. Each inhalation lasted 1–5 seconds, with intervals within one unit of at least 15 seconds. Furthermore, the interval between units was at least 2 hours.

[0118] In Table 3, for questions 1-4, participants answered from five options: "very common," "frequently," "occasionally," "rarely," and "never at all." For questions 5-7, participants answered from five options: "significantly improved," "slightly improved," "minimal change," and "no change." For question 8, participants answered from five options: "able to quit smoking completely," "satisfied even without smoking," "reduced number of cigarettes or smoking frequency," "would like to reduce or quit smoking if continuing," and "no significant change." For question 9, participants answered freely.

[0119] 3. Evaluation Results

[0120] The evaluation results are shown in Table 3 below.

[0121] [Table 3]

[0122]

[0123] As shown in Table 3, inhaling the vapor of the liquid composition of this embodiment using an electronic cigarette can eliminate stress, irritability, and anxiety, and also improve sleep quality. Furthermore, inhaling the vapor of the aforementioned liquid composition also brings various positive effects such as a refreshing sensation and mental clarity.

[0124] Next, the experiences of 93 female or male subjects aged 20–59 before and after inhaling the prepared liquid compositions 2–10 were evaluated. Inhalation of liquid compositions 2–10 was performed in the same manner as inhalation of liquid composition 1. The subjects' evaluation results are shown in Tables 4–11. Furthermore, the numbers in the upper row of each table cell represent the number of participants. The numbers in the lower row represent the percentage of that number relative to the total number of participants for each item.

[0125] [Table 4]

[0126]

[0127] [Table 5]

[0128]

[0129] [Table 6]

[0130]

[0131] [Table 7]

[0132]

[0133] [Table 8]

[0134]

[0135] [Table 9]

[0136]

[0137] [Table 10]

[0138]

[0139] [Table 11]

[0140]

[0141] Industrial practicality

[0142] The liquid composition of the present invention has excellent pressure-reducing properties, and is therefore of industrial applicability as a liquid composition for use in pressure reduction.

[0143] Explanation of reference numerals in the attached figures

[0144] 100… Liquid cartridge; 110… Mouthpiece; 120… Support; 130… Atomizer; 200… Electronic cigarette; 210… Insertion.

Claims

1. A liquid composition comprising an organic solvent and β-caryophyllene, wherein, The content of β-caryophyllene is 0.5 to 10.0% by mass relative to the total amount of the liquid composition.

2. The liquid composition according to claim 1, wherein, The liquid composition also contains a fragrance. The content of the fragrance is 0.5 to 10.0% by mass relative to the total amount of the liquid composition.

3. The liquid composition according to claim 1, wherein, The content of β-caryophyllene is 1.0 to 5.0% by mass relative to the total amount of the liquid composition.

4. The liquid composition according to claim 1, wherein, The organic solvent comprises glycerol and propylene glycol. The content of glycerol W relative to the total amount of the liquid composition. g It ranges from 40.0% to 70.0% by mass. The content of propylene glycol W relative to the total amount of the liquid composition p It ranges from 25.0% to 55.0% by mass. The content of glycerol W g The content of propylene glycol W p The ratio (W) g / W p The value ranges from 0.7 to 3.

0.

5. The liquid composition according to claim 1, wherein, The boiling point of the liquid composition is 90–210 °C.

6. The liquid composition according to claim 1, wherein, The liquid composition is substantially nicotine-free.

7. The liquid composition according to claim 1, wherein, The liquid composition does not contain cannabidiol.

8. The liquid composition according to claim 1, wherein, The liquid composition is used in electronic cigarettes.

9. A liquid e-cigarette cartridge, wherein, The liquid composition is filled with any one of claims 1 to 8.

10. An electronic cigarette comprising the liquid cartridge of claim 9.

Images