Medicine sedimentation volume ratio integrated detection equipment and detection method

Abstract

The invention relates to a medicine sedimentation volume ratio integrated detection device and a detection method, and belongs to the technical field of medicine sedimentation detection. Comprising a shell, a lifting mechanism, a vortex mixing mechanism connected through an elastic connecting piece, a sample bracket, a base, a grouped temperature control mechanism and an optical detection system. The elastic connecting piece allows the sample support subjected to vortex mixing to generate position deviation, and when the lifting mechanism drives the sample support to fall down, the sample support is in pure mechanical fit with the guide part and the positioning column arranged on the positioning seat, so that the plane and angle positions of the sample support are automatically corrected. The rotatable positioning seat further serves as an index plate to drive the sample support to rotate so as to be matched with a fixed optical detection system to conduct time-sharing inspection on all samples. According to the invention, the automation, standardization and high precision of the whole process from uniform sample mixing, multi-temperature-zone temperature control to online imaging detection are realized, and the efficiency of drug stability research and the data reliability are greatly improved.

Description

Technical Field

[0001] This invention relates to an integrated detection device and method for drug sedimentation volume ratio, belonging to the field of drug sedimentation detection technology. Background Technology

[0002] The drug sedimentation volume ratio is a key indicator for evaluating the physical stability of liquid formulations such as suspensions. In the process of developing the technical solution of this application, the inventors discovered at least the following technical problems in the prior art:

[0003] Traditional testing methods heavily rely on manual operation, including manual sample shaking, visual observation and reading, and manual recording. This presents three major bottlenecks: 1. Low standardization: the intensity and method of manual mixing vary from person to person, leading to inconsistent initial conditions and poor experimental repeatability; 2. High subjectivity: visual readings are prone to parallax and judgment errors, resulting in insufficient data accuracy and reliability; 3. Low testing efficiency: unable to meet the demands of high-throughput prescription screening and multi-condition stability testing in modern drug sampling.

[0004] To address these issues, automated and integrated testing equipment has become the focus of sampling inspection. However, such equipment faces a core technical dilemma: on the one hand, to ensure thorough sample mixing, vigorous mechanical motion, such as vortex oscillation, is required, but this inevitably leads to unpredictable positional and angular deviations in the sample-supporting holder after oscillation. On the other hand, subsequent automated temperature control and optical detection require extremely precise positioning of the sample holder to ensure efficient heat transfer and accurate optical imaging. How to automatically and reliably complete the transition from a state of "disordered" vigorous oscillation to a state of "ordered" precise detection within a single device remains a challenge that current technologies have not effectively solved. Summary of the Invention

[0005] The technical problem to be solved by this invention is to overcome the shortcomings of the prior art and provide an integrated drug sedimentation volume ratio detection device. Through a unique mechanical structure design, it cleverly solves the core contradiction between the positional uncertainty caused by vigorous mixing and the high-precision positioning required for subsequent precision detection, thereby realizing full-process automation, standardization and high-precision detection.

[0006] The integrated drug sedimentation volume ratio detection device of the present invention includes: case; The lifting mechanism is located inside the housing; The vortex mixing mechanism is connected to the lifting mechanism via an elastic connector, which allows the vortex mixing mechanism to deviate from its position. A sample holder, detachably placed on the vortex mixing mechanism, is used to support the sample tube; A base is located at the lower end of the interior of the housing, and a positioning seat is provided on it for positioning the sample holder; A temperature control mechanism, located inside the base, is used to control the temperature of the sample tube sample inside the sample holder; An optical detection system, located inside the housing, is used to detect the sample tube sample; When the lifting mechanism lowers the sample holder from the mixing position for vortex mixing to the detection position on the base, the positioning seat cooperates with the sample holder to automatically correct the misalignment of the sample holder caused by the operation of the vortex mixing mechanism.

[0007] Furthermore, the positioning seat can rotate about its central axis; The positioning seat is used to rotate the sample holder after completing the position correction of the sample holder and supporting the sample holder, so as to send the different sample tubes into the detection optical path of the optical detection system in sequence.

[0008] Furthermore, the upper end of the positioning seat is provided with a guide part for correcting misalignment of the plane position, and its outer periphery is provided with a positioning post for adjusting the circumferential position; the positioning post is inserted into the structure corresponding to the sample holder so as to drive the sample holder to rotate synchronously when rotating.

[0009] Furthermore, the elastic connector is provided with multiple springs, the size of which allows the vortex mixing mechanism to generate floating displacement on the horizontal plane.

[0010] Furthermore, the vortex mixing mechanism is provided with a receiving hole, and a spring-loaded support platform is provided at the lower end of the receiving hole to support the sample holder; when the sample holder falls to the detection position, the spring-loaded support platform retracts under the obstruction of the base, so that the lower end surface of the sample holder fits against the upper end surface of the base.

[0011] Furthermore, the optical inspection system includes a parallel backlight source located at the rear of the housing, and a CMOS line scan industrial camera located inside the housing.

[0012] Furthermore, the sample holder includes at least fifteen receiving cavities, each of which has a heat-conducting plate at its bottom.

[0013] Furthermore, the temperature control mechanism includes at least fifteen temperature control components corresponding to the heat conduction plate, each of the temperature control components including a semiconductor cooling chip; the fifteen temperature control components are divided into five groups, each group sharing a cooling fan and equipped with a temperature detection sensor, so as to achieve independent temperature control for each group.

[0014] Furthermore, the lifting mechanism includes: at least two guide rods, a lead screw, a support platform connected to the lead screw and the guide rods, and a servo motor; the vortex mixing mechanism is connected to the support platform through the elastic connector.

[0015] The integrated method for detecting drug sedimentation volume ratio includes the following steps: S1: Place the sample holder on the vortex mixing mechanism in the mixing position; S2: Activate the vortex mixing mechanism to vortex mix the sample tube; S3: Activate the lifting mechanism to lower the sample holder. During the descent, the position and angle deviation of the sample holder are automatically corrected through the mechanical cooperation between the positioning seat and the sample holder, so that it is accurately placed at the detection position. S4: Activate the temperature control mechanism to adjust the temperature of the sample tubes in groups; S5: Imaging and detecting one or more sample tubes located in the detection optical path using the optical detection system; S6: Drive the positioning seat to rotate at a preset angle, causing the sample holder to rotate synchronously, sending the next set of sample tubes into the detection optical path, and repeat step S until all sample tubes have been detected.

[0016] Compared with the prior art, the beneficial effects of the present invention are: This invention cleverly solves the core technical contradiction between vigorous mixing and precise positioning through the synergistic design of "elastic floating connection" and "falling mechanical self-correction", realizing a reliable automatic conversion from disorder to order, and ensuring the stability of equipment operation and the accuracy of subsequent testing.

[0017] The function of the positioning seat has been expanded from a single "positioning" function to "positioning + rotation indexing". A simple mechanism has been used to achieve precise bearing of the sample holder and subsequent time-sharing inspection. The structure is compact and cost-effective.

[0018] It integrates functions such as standardized mixing, automatic alignment, multi-temperature zone sedimentation, and online imaging inspection, realizing unattended operation from sample placement to data output. The data is objective, the results are highly repeatable, and it meets the requirements of modern drug sampling inspection for data integrity. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the structure of Embodiment 1 of the present invention; Figure 2 This is a schematic diagram of the omitted internal structure of the shell in Embodiment 1 of the present invention; Figure 3This is a schematic diagram of the omitted shell and internal light source structure of Embodiment 1 of the present invention; Figure 4 This is one of the schematic diagrams of the sample holder detection position structure in Embodiment 1 of the present invention; Figure 5 This is the second schematic diagram of the sample holder detection position structure in Embodiment 1 of the present invention; Figure 6 This is a rear view of the sample holder detection position in Embodiment 1 of the present invention; Figure 7 This is a schematic diagram of the internal temperature control mechanism of the base in Embodiment 1 of the present invention; Figure 8 This is one of the schematic diagrams of the temperature control mechanism structure in Embodiment 1 of the present invention; Figure 9 This is the second schematic diagram of the temperature control mechanism structure in Embodiment 1 of the present invention; Figure 10 This is a schematic diagram of the vortex mixing mechanism structure of Embodiment 1 of the present invention; Figure 11 This is a schematic diagram of the internal structure of the vortex mixing mechanism in Embodiment 1 of the present invention; Figure 12 This is one of the schematic diagrams of the shell structure in Embodiment 1 of the present invention; Figure 13 This is a second schematic diagram of the shell structure of Embodiment 1 of the present invention; Figure 14 This is a schematic diagram of the positioning seat mechanism structure of Embodiment 1 of the present invention; Figure 15 This is a schematic diagram of the sample holder and positioning column cooperation structure in Embodiment 1 of the present invention; Figure 16 yes Figure 15 Enlarged view of a portion of point A in the middle; Figure 17 This is a schematic diagram of the sample holder structure of Embodiment 1 of the present invention; In the picture: 1. Housing; 11. Third transparent substrate; 12. First transparent substrate; 13. Support plate; 14. Cover plate; 2. Lifting mechanism; 21. Guide rod; 22. Lead screw; 23. Support platform; 24. Servo motor; 3. Vortex mixing mechanism; 31. Receiving hole; 32. Spring-loaded support platform; 33. Drive motor; 34. Vortex frame; 341. Support protrusion; 35. Fixing frame; 36. Pressure plate; 37. Eccentric wheel; 4. Sample holder; 41. Receiving cavity; 411. Observation slot; 42. Heat-conducting plate; 43. Outer peripheral wall; 5. Base; 51. Positioning seat; 511. Guide part; 512. Positioning post; 513. Triangular guide end; 514. Brush head; 52. Drive component; 6. Temperature control mechanism; 61. Temperature control frame; 611. Brush ring; 62. Temperature control component; 621. Semiconductor cooling chip; 622. Cooling fan; 623. Temperature sensor; 7. Optical inspection system; 71. Parallel backlight; 72. Industrial camera; 8. Flexible connectors; 9. Internal light source. Detailed Implementation

[0020] Example 1 like Figures 1 to 17 As shown, to better understand the present invention, the integrated drug sedimentation volume ratio detection device of the present invention will be described in detail below. This device includes an integral housing 1, and a lifting mechanism 2, a vortex mixing mechanism 3, a sample holder 4, a base 5, a temperature control mechanism 6, and an optical detection system 7 disposed inside the housing 1.

[0021] Housing 1 and auxiliary components: such as Figure 12 and Figure 13 As shown, the housing 1 provides a closed, clean, and easily observable working environment for the equipment. An internal light source 9 is fixed at the top of the housing to provide basic illumination inside. First transparent substrates 12, which can be made of glass or transparent acrylic, are fixed to both sides of the housing 1 to ensure lateral transparency. Second and third transparent substrates 11, which can be opened, are located at the front and top of the housing 1, serving as movable doors for easy sample loading and unloading. A removable cover 14 is located at the rear of the housing 1 for easy installation and maintenance of the internal mechanisms.

[0022] Lifting mechanism 2: such as Figure 2 , Figure 3 or Figure 4 As shown, the lifting mechanism 2 is the core component for transferring the sample holder between different functional areas. This mechanism includes at least two guide rods 21 for precision guidance and a lead screw 22 for power transmission. The support platform 23 integrates sliding bearings or sliders that mate with the guide rods 21, and a nut threadedly connected to the lead screw 22. A high-precision servo motor 24 drives the lead screw 22 to rotate, and through the lead screw and nut transmission, drives the support platform 23 to achieve smooth and precise vertical lifting motion. Its position can be controlled in a closed loop by the encoder of the servo motor.

[0023] Vortex mixing mechanism 3 and elastic connector 8: as shown Figure 2 , Figure 10 and Figure 11As shown, the vortex mixing mechanism 3 is suspended below the support platform 23 via multiple large-diameter springs as elastic connectors 8. This flexible connection allows the vortex mixing mechanism 3 to float on the horizontal plane, absorbing vibrations and providing the necessary tolerance space for subsequent self-centering. The vortex mixing mechanism 3 itself includes a fixed frame 35, on which a drive motor 33 is mounted, and an eccentric wheel 37 is connected to the output shaft of the drive motor 33. The eccentric wheel 37 drives a vortex frame 34 divided into upper and lower layers to perform high-speed horizontal circular motion. The upper vortex frame 34 has a receiving hole 31 in the middle for placing the sample holder 4. The lower vortex frame 34 has a support protrusion 341 that abuts against the pressure plate 36 connected to the lower end of the fixed frame 35, forming a stable support structure, thereby allowing the lower end of the support protrusion 341 to move on the upper surface of the pressure plate 36. The lower end of the receiving hole 31 is provided with a spring-loaded support platform 32, which is used to temporarily support the sample holder 4 when in the mixing position. The spring-loaded support platform 32 is installed to the lower end of the upper vortex frame 34 through the guide shell. The spring-loaded support platform 32 is slidably connected inside the guide shell. A spring is provided inside the guide shell to push the spring-loaded support platform 32 out. The lower end of the spring-loaded support platform 32 is provided with an arc-shaped surface, which is used to retract when it contacts the outer edge of the upper end of the base 5.

[0024] Sample holder 4: such as Figure 4 , Figure 5 , Figure 6 As shown, the sample holder 4 is a movable sample carrier with fifteen receiving cavities 41. To achieve heat isolation during independent temperature control, the receiving cavities 41 are connected by as few connecting structures as possible (mainly through the outer peripheral wall 43). To facilitate optical detection, each receiving cavity 41 has a vertical observation slot 411 on its side wall. The bottom of each receiving cavity 41 is embedded with a heat-conducting plate 42 (such as copper or aluminum) with excellent thermal conductivity for efficient heat exchange with the temperature control component below. The sample tubes are preferably made of flat-bottomed high borosilicate material.

[0025] Base 5 and positioning seat 51: as follows Figures 2-7 As shown, the base 5 is cylindrical and connected to the support plate 13 inside the housing 1 by screws. A through hole is provided at the bottom of the housing 1 corresponding to the mounting position of the base 5, mainly for heat dissipation of the temperature control mechanism 6. A drive unit 52 is mounted on the base 5, with its output end extending beyond the upper surface of the base. The output end of the drive unit 52 (preferably a closed-loop stepper motor with an encoder) extending beyond the upper surface of the base 5 is keyed to the positioning seat 51, used to drive it for precise angle division. Precise angle division is achieved through the encoder and is also used for later position correction. The upper edge of the positioning seat 51 has a tapered guide portion 511, and its outer periphery has multiple vertically arranged positioning posts 512. The upper end of each positioning post 512 has a triangular guide end 513 for guidance, facilitating quick and accurate engagement with the sample holder 4.

[0026] Temperature control mechanism 6: such as Figure 7 , Figure 8 , Figure 9 As shown, the temperature control mechanism 6 is located within the base 5 and includes a temperature control frame 61 for mounting the temperature control components 62. Fifteen temperature control components 62 correspond one-to-one with the workstations of the sample holder 4. The core of each temperature control component 62 is a semiconductor cooling chip 621 that can both cool and heat. All temperature control components are divided into five groups of three. For heat dissipation, each group shares a high-efficiency cooling fan 622. For temperature detection, each group has an independent temperature sensor 623. Through a PID closed-loop control algorithm, five independent temperature controls are achieved for the sample. Temperature control is achieved through the bidirectional operating characteristics and precise adjustment of the semiconductor cooling chip 621. The bidirectional operating characteristics are: when direct current flows through the semiconductor cooling chip 621 in one direction, one surface absorbs heat (cooling), while the other surface releases heat. When the current direction is reversed, the previously cooling surface releases heat (heating), while the previously heat-releasing surface absorbs heat. Precision adjustment basis: By precisely controlling the direction and magnitude of the direct current flowing through the semiconductor cooling chip 621, its cooling or heating power can be precisely controlled.

[0027] Optical inspection system 7: such as Figure 5 or Figure 6 As shown, the optical inspection system 7 consists of a parallel backlight 71 located inside the positioning base 51 and a CMOS line scan industrial camera 72 located at the rear of the housing 1. The optical paths of the two are precisely aligned, forming a narrow, elongated vertical inspection area. When the sample holder 4 is in the inspection position, an observation slot 411 on it is precisely located within this inspection area. The parallel light emitted by the parallel backlight 71 passes through the sample and is captured line by line by the line scan industrial camera 72, forming a high-resolution, distortion-free sample image. The parallel backlight 71 passes through the brush ring 611 on the temperature control frame 61 (e.g., ...). Figure 8 (as shown) and the brush head 514 at the lower end of the positioning seat 51 (as shown) Figure 14 (As shown) to provide electrical energy.

[0028] Working principle: Phase 1: Sample loading and standardized vortex mixing.

[0029] The operation begins at the highest functional position of the equipment—the mixing zone.

[0030] Sample placement: The operator easily inserts the sample holder 4 containing the sample tube to be tested into the receiving hole 31 of the vortex mixing mechanism 3 from above. At this time, the holder is elastically supported by the spring-loaded support platform 32 and is in a ready state.

[0031] Initiation of mixing: The drive motor 33 is started by the control system, and its output shaft drives the eccentric wheel 37 to rotate at high speed. The motion of the eccentric wheel 37 drives the connected vortex frame 34 to produce violent horizontal circular oscillations.

[0032] Energy transfer: This high-frequency oscillation is precisely transmitted to each sample tube inside the sample holder 4, causing strong eddies in the drug solution inside. This ensures that the drug particles can be fully and uniformly redispersed, eliminating the differences in technique caused by manual shaking and establishing a completely consistent initial state for the sedimentation behavior of all subsequent samples.

[0033] Flexible suspension: The entire vortex mixing mechanism 3 is suspended below the support platform 23 of the lifting mechanism 2 via elastic connectors 8 (such as springs). This flexible connection not only effectively isolates the transmission of vibration to the main body of the equipment, but more importantly, it allows the sample holder 4 to be in a "floating" state after mixing, allowing for slight positional and orientation deviations, thus reserving the necessary tolerance space for the next stage of self-alignment.

[0034] Phase Two: Automated Transfer and Passive High-Precision Self-Alignment.

[0035] This stage is crucial for achieving seamless integration between different functional areas. Its core is a purely mechanical, passive self-centering principle, which has extremely high reliability.

[0036] Vertical lowering: After mixing is completed, the servo motor 24 of the lifting mechanism 2 drives the lead screw 22 to rotate, which drives the support platform 23 and all components above it to descend vertically smoothly and at a uniform speed.

[0037] Position alignment (coarse positioning): During the descent, the outer peripheral wall 43 of the sample holder 4 will first contact the tapered guide portion 511 on the upper edge of the bottom positioning seat 51. Under the action of gravity, the sample holder 4 will slide naturally along the tapered inclined surface until its central axis is completely coincident with the central axis of the positioning seat 51, thereby automatically correcting any planar position deviation that may occur after mixing.

[0038] Angle alignment (precise positioning): As the sample holder 4 continues to descend, the preset positioning structure on the sample holder 4 will engage with multiple positioning posts 512 on the positioning seat 51. The triangular guide end 513 at the top of the positioning post 512 can guide the holder to fit in easily and accurately, ultimately achieving precise locking of the holder's angle and ensuring that each sample tube is in the preset precise angular coordinate.

[0039] The third stage: parallel temperature control and sedimentation in multiple temperature zones.

[0040] Once self-alignment is complete, sample holder 4 is precisely positioned in the temperature control and detection zone.

[0041] Efficient heat transfer: The moment the sample holder 4 is seated, the heat-conducting plate 42 at the bottom of each of its accommodating chambers comes into close contact with the corresponding temperature control components 62 in the temperature control mechanism 6 below, establishing an efficient heat transfer channel. At the same time, as the falling and rebounding support platform 32 is pushed back, the support for the sample holder 4 is released.

[0042] Independent Group Temperature Control: The system activates the temperature control mechanism 6. Fifteen temperature control components 62 are divided into five groups, each monitored in real time by an independent temperature sensor 623. Precise PID closed-loop temperature control is achieved by controlling the direction and magnitude of the current in the semiconductor cooling chip 621. This allows the equipment to simultaneously apply different ambient temperatures (e.g., 4℃, 25℃, 40℃, 50℃, 60℃) to five groups of samples for parallel comparative experiments, significantly shortening the sampling cycle.

[0043] Phase 4: Online optical scanning and rotary inspection.

[0044] The sample begins to settle at a set temperature, and the system performs periodic automated detection according to a preset program.

[0045] Step 1 Single-point imaging: At the preset detection time point, the optical detection system 7 is activated. The parallel beam emitted by the parallel backlight 71 penetrates the sample tube that is in the detection optical path (through the observation slot 411 on its side wall). The industrial camera 72 (line scan CMOS) located on the other side scans line by line to acquire a high-resolution, distortion-free vertical cross-sectional image of the sample.

[0046] Step 2 Data Processing: The image data is transmitted to the central processing unit. Through advanced image processing algorithms, the clear interface between the sediment and the supernatant is automatically identified and marked, the sediment volume or height is accurately calculated, and the data is recorded together with the current time point and sample information.

[0047] Step 3 Rotation Inspection: After the inspection of one sample is completed, the drive unit 52 (stepper motor) precisely drives the positioning seat 51 to rotate by a fixed angle (e.g., 24°). Due to the rigid connection between the positioning column 512 and the sample holder 4, the sample holder 4 also rotates synchronously and precisely by the same angle, accurately sending the next sample tube into the detection optical path.

[0048] Step 4: Cyclic Detection: The system repeats steps 1 to 3, like a radar scan, to complete the rapid detection of all fifteen samples in sequence.

[0049] Step 5: Full-time monitoring: After completing one round of inspection, the equipment enters a static waiting state until the next preset time point arrives. At that time, it will automatically wake up and repeat a new round of rotational inspection. This cycle repeats until the entire experimental period ends, ultimately obtaining a complete and accurate curve of the sedimentation volume of each sample changing over time at different temperatures.

[0050] The integrated detection method of the present invention is as follows: S1: Sample loading. The operator opens the upper door and places the sample holder 4 containing the test drug on the vortex mixing mechanism 3 at the highest mixing position. At this time, the sample holder 4 is elastically supported by the spring-loaded support platform 32.

[0051] S2: Standardized Mixing. The central controller issues a command to start the drive motor 33 inside the vortex mixing mechanism 3. The eccentric wheel 37 drives the vortex frame 34 to oscillate at high speed, thereby performing standardized vortex mixing on all sample tubes inside the sample holder 4. Due to the presence of the elastic connector 8, there will be slight positional and angular deviations in the sample holder 4 after mixing.

[0052] S3: Falling and Self-Centering. The central controller commands the lifting mechanism 2 to start, and the servo motor 24 drives the lead screw 22, causing the sample holder 4 to fall at a constant speed. During the fall, the outer peripheral wall 43 of the sample holder 4 first contacts the guide part 511 of the positioning seat 51, and slides along the inclined plane under the action of gravity, achieving automatic centering of the horizontal position. Immediately afterwards, the sample holder 4 continues to fall, and the corresponding structure (such as holes or slots) on it will fit into the triangular guide end 513 of the positioning post 512, and finally fully engage, thereby achieving automatic correction of the angular position. This process is a purely mechanical passive self-centering, with extremely high reliability. At the same time, the spring-loaded support platform 32 is pushed back by the base 5, so that the heat-conducting plate 42 of the sample holder 4 and the temperature control component 62 are in close contact and correspond one-to-one.

[0053] S4: Multi-zone parallel temperature control. After positioning, the central controller activates the temperature control mechanism 6 to group and regulate the temperature of the samples according to a preset program. For example, fifteen sample tubes can be grouped into three groups, each regulated at 4°C, 25°C, 40°C, 50°C, and 60°C, to conduct efficient parallel comparison experiments.

[0054] S5: Online Imaging Inspection. The central controller activates the optical inspection system 7, the parallel backlight 71 illuminates, and the industrial camera 72 scans and images the first sample tube located in the inspection optical path through its observation slot 411. The image data is transmitted to the central processor, where image processing algorithms automatically identify the sedimentation interface and record the data.

[0055] S6: Rotational Inspection. After imaging a single sample, the central controller instructs the drive unit 52 to rotate the positioning seat 51 by a preset angle (e.g., 24 degrees). The positioning seat 51, through the positioning column 512, drives the sample holder 4 to rotate synchronously and precisely, sending the next sample tube into the detection optical path. Then, step S5 is repeated. This inspection process is repeated cyclically until all sample tubes have been inspected at a given time point. The equipment then enters a static settling state, and at each subsequent preset time point, the inspection process of S5 and S6 will be automatically repeated until the entire experiment is completed.

[0056] The descriptions of the orientation and relative positional relationships of the structures in this invention, such as front, back, left, right, up, and down, do not constitute a limitation of this invention, but are merely for the convenience of description.

Claims

1. An integrated detection device for drug sedimentation volume ratio, characterized in that, include: Shell (1); The lifting mechanism (2) is located inside the housing (1); The vortex mixing mechanism (3) is connected to the lifting mechanism (2) via an elastic connector (8), which allows the vortex mixing mechanism (3) to deviate from its position. The sample holder (4) is detachably placed on the vortex mixing mechanism (3) to support the sample tube; The base (5) is located at the lower end of the interior of the housing (1), and a positioning seat (51) is provided on it for positioning the sample holder (4). Temperature control mechanism (6) is located inside the base (5) and is used to control the temperature of the sample tube sample inside the sample holder (4); An optical detection system (7) is located inside the housing (1) and is used to detect the sample tube sample; When the lifting mechanism (2) drives the sample holder (4) to fall from the mixing position for vortex mixing to the detection position on the base (5), the positioning seat (51) cooperates with the sample holder (4) to automatically correct the misalignment of the sample holder (4) caused by the operation of the vortex mixing mechanism (3).

2. The integrated drug sedimentation volume ratio detection device according to claim 1, characterized in that, The positioning seat (51) can rotate about its central axis; The positioning seat (51) is used to drive the positioning seat (51) to rotate and drive the sample holder (4) to rotate after the position of the sample holder (4) is corrected and the sample holder (4) is supported. This allows different sample tubes to be sent into the detection optical path of the optical detection system (7) in sequence.

3. The integrated drug sedimentation volume ratio detection device according to claim 2, characterized in that, The upper end of the positioning seat (51) is provided with a guide part (511) for correcting misalignment of the plane position, and the outer periphery is provided with a positioning post (512) for adjusting the circumferential position; the positioning post (512) is inserted into the structure corresponding to the sample holder (4) so ​​as to drive the sample holder (4) to rotate synchronously when rotating.

4. The integrated drug sedimentation volume ratio detection device according to claim 1, characterized in that, The elastic connector (8) is provided with multiple springs, the size of which allows the vortex mixing mechanism (3) to generate floating displacement on the horizontal plane.

5. The integrated drug sedimentation volume ratio detection device according to claim 1, characterized in that, The vortex mixing mechanism (3) is provided with a receiving hole (31), and the lower end of the receiving hole (31) is provided with a spring-loaded support platform (32) for supporting the sample holder (4); when the sample holder (4) falls to the detection position, the spring-loaded support platform (32) retracts under the obstruction of the base (5), so that the lower end surface of the sample holder (4) is attached to the upper end surface of the base (5).

6. The integrated drug sedimentation volume ratio detection device according to claim 1, characterized in that, The optical inspection system (7) includes a parallel backlight (71) located at the rear of the housing (1) and a CMOS line scan industrial camera (72) located inside the housing (1).

7. The integrated drug sedimentation volume ratio detection device according to claim 1, characterized in that, The sample holder (4) includes at least fifteen receiving cavities (41), and each receiving cavity (41) has a heat-conducting plate (42) at its bottom.

8. The integrated drug sedimentation volume ratio detection device according to claim 7, characterized in that, The temperature control mechanism (6) includes at least fifteen temperature control components (62) corresponding to the heat conduction plate (42), each of the temperature control components (62) including a semiconductor cooling chip (621); the fifteen temperature control components (62) are divided into five groups, each group sharing a cooling fan (622) and a temperature detection sensor (623) to achieve independent temperature control for each group.

9. The integrated drug sedimentation volume ratio detection device according to claim 1, characterized in that, The lifting mechanism (2) includes: at least two guide rods (21), a lead screw (22), a support platform (23) connected to the lead screw (22) and the guide rods (21), and a servo motor (24); the vortex mixing mechanism (3) is connected to the support platform (23) through the elastic connector (8).

10. A method for integrated detection of drug sedimentation volume ratio, based on the integrated detection device for drug sedimentation volume ratio as described in claim 1, characterized in that, Includes the following steps: S1: Place the sample holder (4) on the vortex mixing mechanism (3) in the mixing position; S2: Start the vortex mixing mechanism (3) to vortex mix the sample tube; S3: Start the lifting mechanism (2) to drive the sample holder (4) to fall. During the falling process, the position and angle deviation of the sample holder (4) are automatically corrected through the mechanical cooperation between the positioning seat (51) and the sample holder (4) so ​​that it falls precisely at the detection position. S4: Activate the temperature control mechanism (6) to adjust the temperature of the sample tubes in groups; S5: Image detection is performed on one or more sample tubes located in the detection optical path by the optical detection system (7); S6: Drive the positioning seat (51) to rotate at a preset angle, drive the sample holder (4) to rotate synchronously, send the next set of sample tubes into the detection optical path, and repeat step S5 until all sample tubes are detected.

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