Hair growth essence composition and application thereof

Abstract

The invention relates to the field of hair growth and care, and provides a hair growth essence composition which comprises the following components in percentage by weight: 10%-36% of plant extract, 0.7%-8% of penetrant, 0.9%-2.3% of amino acid substances, 0.5%-5% of biotin, 5.0%-10% of water-soluble polysaccharide, 0.8%-2.5% of stabilizer and the balance of vegetable oil, totaling 100%. By means of the synergistic effect of all the components, the composition can enable scalp and hair follicle cells to rapidly induce and stimulate stem cell generation and differentiation, hair growth is accelerated, and hair is nourished.

Description

Technical Field

[0001] This application relates to the field of hair growth and care, A61K127 / 00, and specifically to a hair growth essence composition and its application. Background Technology

[0002] Modern daily life reveals a growing trend of hair loss, particularly among younger women, due to increased work and life stress, excessive mental exertion, changes in diet and social environment. Research on the causes of hair loss in this population suggests several factors: poor scalp blood circulation, excessive sebum secretion, excessive androgen secretion, scalp dysfunction caused by peroxidation and bacteria, aging, genetic factors, and stress. Given the complex nature of hair loss, addressing the root causes—including inhibiting hair loss, nourishing hair follicles, stimulating scalp cell regeneration, and promoting healthy hair growth—is a crucial issue that needs to be addressed.

[0003] Chinese patent CN106511615A discloses a traditional Chinese medicine liquid for hair growth and anti-hair loss, and its preparation method. The raw materials of the liquid include: Polygonum multiflorum, Platycladus orientalis leaves, mulberry leaves, ginseng, Salvia miltiorrhiza, wolfberry, black beans, and black sesame seeds. Although these traditional Chinese medicine preparations are beneficial for hair growth and nourishment, they require long-term nourishment, and these preparations are difficult to penetrate the scalp and stratum corneum, thus limiting their effectiveness. Chinese patent CN103720752A discloses a topical preparation for hair growth and nourishment, and its preparation method. The technology uses minoxidil to treat alopecia areata, androgenetic alopecia, and other types of hair loss. While minoxidil has a good short-term effect on improving the scalp environment, poor compatibility with other substances can easily lead to reduced efficacy and product instability. In addition, long-term use of Western medicine may have adverse effects on the human body. Summary of the Invention

[0004] To address the aforementioned technical problems, this application provides a hair growth essence composition, the composition comprising: plant extracts, penetrants, amino acids, biotin, water-soluble polysaccharides, stabilizers, and plant oils.

[0005] Furthermore, the composition comprises: 10%-36% plant extracts, 0.7%-8% penetrant, 0.9%-2.3% amino acids, 0.5%-5% biotin, 5.0%-10% water-soluble polysaccharides, 0.8%-2.5% stabilizer, and vegetable oil to make up the balance to a total of 100%.

[0006] Plant extracts and oils contain a complex and diverse range of components, including polyphenols, sugars, amino acids, terpenes, flavonoids, and alkaloids. Their natural active ingredients possess bioactivity that scavenges free radicals, combats pathogenic skin fungi and bacteria, and provides nourishment to the scalp. Controlling their content is crucial to maximizing their efficacy. Since the number of target substances stimulating keratin synthesis and hair growth on the scalp is limited, excessive amounts can lead to underutilization of some of the active ingredients, resulting in waste and potentially affecting their stability. Penetrants act as a medium carrying plant extracts, allowing them to bind to target sites on the scalp and hair shaft, accelerating the delivery of active ingredients to the scalp and hair surface and promoting absorption. Amino acids, biotin, and water-soluble polysaccharides provide a nutrient-rich environment for hair growth.

[0007] Furthermore, the plant extracts are derived from sesame seeds (Sesamumindicum), olives (Canaviumalbum Raeuseh), Polygonum multiflorum (Thunb.), Gleditsia sinensis (Spina Gleditsiae), Firmiana simplex (Firmiana simplex), ginseng (Ginseng Radix et Rhizoma), flax seeds (Flax Lignans), Japonica, Artemisia annuae, Curcuma longae (Curcumae Longae Rhizoma), red clover (Trifolium pratense), mulberry (Fructus Mori), aloe vera, lavender, rose (Rosa rugosa), Pinus massoniana Lamb, Citrus medica var. sarcodactylis, eucalyptus, Imperata cylindrica, and jojoba seeds (Simmondsia). One or more of the following: chinensis, grape seed (Vitis vinifera), and tea (Camellia sinensis).

[0008] Further, the plant extract is one or more of the following: olive fruit extract (CAS# 84012-27-1), Oriental Ficus leaf extract (CAS# 77-52-1), ginseng extract (CAS# 90045-38-8), flaxseed extract (CAS# 148244-82-0), japonica scutellaria extract, artemisia annua extract (CAS# 63968-94-9), turmeric extract (CAS# 458-37-7), red clover extract (CAS# 85085-25-2), bergamot extract (CAS# 7380-40-7), and aloe vera extract (CAS# 8001-97-6).

[0009] In a preferred embodiment, the plant extract is a combination of Oriental Philodendron leaf extract, red clover extract, turmeric extract, artemisia annua extract, flaxseed extract, and japonica glutinosa extract.

[0010] Red clover extract's main active ingredient is isoflavones, which have antioxidant, anti-inflammatory, antibacterial, and bidirectional regulatory effects on human hormone balance, as well as the ability to scavenge free radicals. Turmeric extract's main component is curcumin, which has anti-inflammatory, antibacterial, and antioxidant effects. Artemisia annua extract has excellent inhibitory effects on Staphylococcus epidermidis, Moraxella catarrhalis, Staphylococcus aureus, Pseudomonas aeruginosa, and dermatophytes, exhibiting broad-spectrum antibacterial properties. Flaxseed extract is rich in linolenic acid, linolenic acid, and other unsaturated fatty acids, which have good antioxidant effects, can scavenge free radicals in the body, reduce fine lines on the skin, and regulate sebum secretion in oily skin.

[0011] Furthermore, the mass ratio of the plant extracts, including the leaf extract of *Firmiana simplex*, the extract of *Clerodendrum trichotomum*, the extract of turmeric, the extract of *Artemisia annua*, the extract of flaxseed, and the extract of *Japonica glutinosa*, is (0.2-2.2): (2-9): (2-8): (6-9): (2.5-6): (1.8-5.8).

[0012] Furthermore, the mass ratio of the plant extracts, including the leaf extract of *Firmiana simplex*, the extract of *Clerodendrum trichotomum*, the extract of turmeric, the extract of *Artemisia annua*, the extract of flaxseed, and the extract of *Japonica glutinosa*, is (0.2-1.8):(2-8):(2-8):(6-8):(2.5-6):(1.8-4.2).

[0013] In a preferred embodiment, the mass ratio of the plant extracts—including the leaf extract of *Firmiana simplex*, the extract of *Clerodendrum trichotomum*, the extract of turmeric, the extract of *Artemisia annua*, the extract of flaxseed, and the extract of *Japonica glutinosa*—is 1.2:5:5:7:4.5:3.1.

[0014] Furthermore, the penetrant is one or more of alkylamides, active peptides, azone, and isosorbide dimethyl ether.

[0015] Furthermore, the alkylamide is one of N,N-bishydroxyethylalkylamide, fatty amide betaine, or alkylamide phosphate betaine.

[0016] In a preferred embodiment, the penetrant is an active peptide.

[0017] Furthermore, the molecular weight of the active peptide is 500-1500 Daltons. At this molecular weight, the active peptide has higher biological activity and can carry the macromolecules present in plant extracts and plant oils to reach and penetrate the skin surface as quickly as possible, stimulating the activation and differentiation of scalp stem cells into new dermal and hair follicle cells, thereby initiating the growth of new hair in the scalp hair follicles and improving scalp health.

[0018] Furthermore, the molecular weight of the active peptide is 500-1000 Daltons.

[0019] Furthermore, the active peptide is one or a combination of several of the following: pea peptide, silk fibroin peptide, cell-stimulating peptide, wool keratin nanopeptide, germination peptide, oligopeptide, and aspartic acid hexapeptide.

[0020] Furthermore, the active peptide is a combination of pea peptide, cell-stimulating peptide, and germination peptide. Pea peptide contains pea protein and eight essential amino acids, which can rapidly revitalize cells and have high antioxidant activity; cell-stimulating peptide has the characteristics of inverse concentration-strength absorption and multi-target biological regulation, which can stimulate rapid cell growth and differentiation, and has the effects of delaying skin aging and repairing diseased tissues; germination peptide contains a variety of amino acids and has the effect of stimulating growth hormone secretion; the synergistic effect of the three can rapidly promote hair growth.

[0021] Further, the mass ratio of the pea peptide, cell-stimulating peptide, and germination peptide is (0.2-3):(0.1-4.0):(0.1-2.5).

[0022] Further, the mass ratio of the pea peptide, cell-stimulating peptide, and germination peptide is (0.5-2.5):(0.1-3):(0.18-2.3).

[0023] Furthermore, the amino acid is one of histidine, arginine, and proline.

[0024] Preferably, the amino acid is arginine.

[0025] Furthermore, the water-soluble polysaccharides include, but are not limited to, carboxymethyl chitosan, water-soluble soybean polysaccharides, dextran, and hydroxyethyl cellulose.

[0026] Furthermore, the stabilizer is a compound containing at least one nitrogen atom and a conjugated ring. By adding the stabilizer, intermolecular forces are generated between the stabilizer and the polar bonds such as OH, NH, CO, CN, etc., and conjugated structures (such as double bonds, triple bonds, or cyclic structures) contained in the plant extracts, plant oils, and amino acids in the system, thereby better stabilizing the system and promoting the synergistic effect of each substance.

[0027] Furthermore, the stabilizer is one of zinc pyridinethione, bromoaniline maleate, and tetrahydropiperidine.

[0028] In a preferred embodiment, the stabilizer is tetrahydropiperidine; tetrahydropiperidine not only stabilizes plant extracts, amino acids and plant oils, but also enhances the absorption of the composition in the scalp, effectively delivering functional ingredients and providing nourishing and protective effects.

[0029] Furthermore, the vegetable oil is one or a combination of several of the following: pear oil (CAS# 8024-32-6), jojoba oil (CAS# 61789-91-1), palm oil (CAS# 8002-75-3), coconut oil (CAS# 8001-31-8), pine nut oil (CAS# 91771-47-0), and sea buckthorn seed oil (CAS# 90106-68-6).

[0030] Furthermore, the vegetable oil is a combination of pear oil and sea buckthorn seed oil.

[0031] Furthermore, the mass ratio of camphor pear oil and sea buckthorn seed oil in the vegetable oil is (0.5-4):1.

[0032] Beneficial effects: 1. The hair growth essence composition of this application is mostly derived from natural plants, and its components are mild, safe and non-irritating to the scalp, thus expanding the scope of the applicable population of this invention.

[0033] 2. The plant extracts and plant oils in this application include substances such as polyphenols, sugars, amino acids, terpenes, flavonoids, and alkaloids. By utilizing the synergistic effect of each component in the composition, the composition of this application has a strong free radical scavenging effect, biological activity against pathogenic skin fungi and bacteria, and can directly stimulate the production of hair growth factors. It can be used in products with hair growth, hair nourishment, and hair care effects.

[0034] 3. This application specifies that the molecular weight of the active peptide is 500-1500 Daltons, and that the active peptide is a combination of pea peptide, cell-stimulating peptide, and germination peptide in a mass ratio of (0.2-3):(0.1-4.0):(0.1-2.5), which enables the effective substances in plant extracts and plant oils to reach and penetrate the scalp surface more quickly and fully, so that the scalp and hair follicle cells can be rapidly induced to stimulate the production and differentiation of stem cells, thereby accelerating and improving hair growth.

[0035] 4. The content of each component is limited in this application to ensure that its effective function is fully exerted, while improving the compatibility of each component and making the composition of this application have strong stability. Detailed Implementation

[0036] Example Example 1 A hair growth essence composition, wherein the composition comprises, by weight percentage, 23% plant extracts, 4.5% penetrant, 1.6% amino acids, 3.2% biotin, 8% water-soluble polysaccharides, 1.5% stabilizer, and plant oil to make up the balance to 100%.

[0037] The plant extract is a combination of Oriental Philodendron leaf extract, red clover extract, turmeric extract, artemisia annua extract, flaxseed extract, and japonica glutinosa extract, with a mass ratio of 1.2:5:5:7:4.5:3.1.

[0038] The penetrant is an active peptide with a molecular weight of 850 Daltons. The active peptide is a combination of pea peptide, cell-stimulating peptide, and germination peptide in a mass ratio of 1:1:1.

[0039] The amino acid in question is L-arginine.

[0040] The water-soluble polysaccharide is carboxymethyl chitosan.

[0041] The stabilizer is tetrahydropiperidine.

[0042] The vegetable oil is a combination of pear oil and sea buckthorn seed oil in a mass ratio of 2.2:1.

[0043] Example 2 A hair growth essence composition, wherein the composition comprises, by weight percentage, 10% plant extract, 1.0% penetrant, 2.3% amino acids, 5% biotin, 10% water-soluble polysaccharide, 0.8% stabilizer, and plant oil to make up the balance to 100%.

[0044] The plant extract is a combination of Oriental Philodendron leaf extract, red clover extract, turmeric extract, artemisia annua extract, flaxseed extract, and japonica glutinosa extract, in a mass ratio of 1.8:8:2:8:6:4.2.

[0045] The penetrant is an active peptide with a molecular weight of 500 Daltons. The active peptide is a combination of pea peptide, cell-stimulating peptide, and germination peptide in a mass ratio of 0.5:3:0.2.

[0046] The amino acid in question is L-arginine.

[0047] The water-soluble polysaccharide is carboxymethyl chitosan.

[0048] The stabilizer is tetrahydropiperidine.

[0049] The vegetable oil is a combination of pear oil and sea buckthorn seed oil in a mass ratio of 0.5:1.

[0050] Example 3 A hair growth essence composition, wherein the composition comprises, by weight percentage, 36% plant extracts, 8% penetrant, 0.9% amino acids, 0.5% biotin, 5% water-soluble polysaccharides, 2.5% stabilizer, and plant oil to make up the balance to 100%.

[0051] The plant extract is a combination of Oriental Philodendron leaf extract, red clover extract, turmeric extract, artemisia annua extract, flaxseed extract, and japonica glutinosa extract, in a mass ratio of 0.2:2:8:6:2.5:1.8.

[0052] The penetrant is an active peptide with a molecular weight of 1000 Daltons. The active peptide is a combination of pea peptide, cell-stimulating peptide, and germination peptide in a mass ratio of 2.5:0.1:2.3.

[0053] The amino acid in question is L-arginine.

[0054] The water-soluble polysaccharide is carboxymethyl chitosan.

[0055] The stabilizer is tetrahydropiperidine.

[0056] The vegetable oil is a combination of pear oil and sea buckthorn seed oil in a mass ratio of 4:1.

[0057] Comparative Example 1 Same as Example 1, except that: plant extract 50%, penetrant 4.5%, amino acid substances 1.6%, biotin 3.2%, water-soluble polysaccharide 8%, stabilizer 2.5%, and plant oil to make up the balance to 100%.

[0058] Comparative Example 2 Same as Example 1, except that the active peptide is a combination of pea peptide, cell-stimulating peptide and germination peptide in a mass ratio of 5:3:0.2.

[0059] Comparative Example 3 Same as Example 1, except that: the plant extract is a combination of Oriental Philodendron leaf extract, red clover extract, turmeric extract, Artemisia annua (Chinese Artemisia) extract, flaxseed extract, and japonica rice extract, in a mass ratio of 3:2:10:6:2.5:1.

[0060] In the above embodiments, the pea peptide was purchased from Shaanxi Xinyanghe Biotechnology Co., Ltd.; the germination peptide was purchased from Xihai Biotechnology Co., Ltd.; the carboxymethyl chitosan was purchased from Virgin Biotechnology Co., Ltd.; and the biotin was purchased from Yanquan Biotechnology Co., Ltd.

[0061] Performance testing methods: 1. Effects of Clinical Trial on Hair Plucking Gene Expression: Twelve subjects used an undiluted hair growth serum composition, applied twice daily for two weeks. Twenty follicle pools were collected before and after treatment to extract sufficient RNA for quantitative gene expression profiling. Thirty genes important for hair physiology were subsequently tracked. In Example 1, the average expression growth rates of fibroblast growth factor 7 (FGF7) and noggin in the 12 subjects were 62% and 86%, respectively.

[0062] 2. Stability test: The hair growth essence composition in the example was stored at 45℃, 25℃ and -18℃ for 30 days. The product was observed for any adverse phenomena such as layering, precipitation, color change, decrease in viscosity or thickening. If no adverse phenomena were observed after storage at each temperature, the stability test of the composition was deemed to have passed. The test results of the example are shown in Table 1.

[0063] Performance test results: Table 1

Claims

1. A hair growth essence composition, characterized in that, The composition comprises: plant extracts, plant oils, penetrants, amino acids, biotin, water-soluble polysaccharides, and stabilizers.

2. The hair growth essence composition according to claim 1, characterized in that, The composition comprises, by weight percentage, 10%-36% plant extracts, 0.7%-8% penetrant, 0.9%-2.3% amino acids, 0.5%-5% biotin, 5.0%-10% water-soluble polysaccharides, 0.8%-2.5% stabilizer, and vegetable oil to make up the balance to 100%.

3. The hair growth essence composition according to claim 1, characterized in that, The plant extracts are derived from one or more of the following: sesame seeds, olives, Polygonum multiflorum, Gleditsia sinensis, Pterocarya stenoptera leaves, ginseng, flax seeds, japonica safflower, Artemisia annua, turmeric, red clover, mulberry, aloe vera, lavender, rose, Pinus massoniana wood, bergamot, eucalyptus fruit, Imperata cylindrica flowers, jojoba seeds, grape seeds, and tea.

4. The hair growth essence composition according to claim 1, characterized in that, The penetrant is one or more of alkylamides, active peptides, azone, and isosorbide dimethyl ether.

5. The hair growth essence composition according to claim 4, characterized in that, The alkylamide is one of N,N-bishydroxyethylalkylamide, fatty amide betaine, and alkylamide phosphate betaine.

6. The hair growth essence composition according to claim 4, characterized in that, The molecular weight of the active peptide is 500-1500 Daltons.

7. The hair growth essence composition according to claim 6, characterized in that, The active peptide is one or a combination of several of the following: pea peptide, silk fibroin peptide, cell-stimulating peptide, wool keratin nanopeptide, germination peptide, oligopeptide, and aspartic acid hexapeptide.

8. The hair growth essence composition according to claim 1, characterized in that, The stabilizer is a compound containing at least one nitrogen atom and a conjugated ring.

9. The hair growth essence composition according to claim 8, characterized in that, The stabilizer is one of zinc pyridinethione, bromoaniline maleate, or tetrahydropiperidine.

10. The application of the hair growth essence composition according to claims 1-9 in products with hair growth, hair nourishment and hair care effects.

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