Medical pressure belt based on nylon-spandex elastic flannelette and preparation method of medical pressure belt

Abstract

The invention discloses a medical pressure belt based on nylon spandex elastic flannelette and a preparation method of the medical pressure belt, and relates to the technical field of medical pressure belts. The preparation method comprises the following steps: pretreating brocade spandex elastic flannelette through alkali washing and acid washing, immersing the brocade spandex elastic flannelette into an epsilon-polylysine solution to form a bottom coating, dispersing composite phthalocyanine powder consisting of water-soluble phthalocyanine dye, monosubstituted beta-carboxyl zinc phthalocyanine and iron phthalocyanine derivatives, adjusting the pH value, adding an auxiliary agent to prepare slurry, dip-dyeing a base material with the bottom coating, pre-drying, and curing to obtain a finished product. The pressure belt integrates the functions of efficient antibiosis, deodorization and dyeing, the coating is high in adhesive force, washable and durable, the base material is elastically attached, the biological safety is high, and the pressure belt is suitable for the scenes of clinical infection prevention, postoperative care and the like.

Description

A medical pressure band based on nylon-spandex elastic fleece and its preparation method Technical Field

[0001] This invention relates to the field of medical pressure belt technology, specifically a medical pressure belt based on nylon-spandex elastic fleece and its preparation method. Background Technology

[0002] Medical pressure bands, as commonly used clinical medical consumables, are widely used in postoperative hemostasis, edema prevention, and wound care. Their functionality and practicality directly affect treatment outcomes and patient experience. Currently, existing medical pressure bands generally suffer from several technical bottlenecks: First, their antibacterial mechanisms are limited, often relying on a single antibacterial component, which has limited inhibitory effects on drug-resistant bacteria (such as MRSA), and long-term use can easily lead to bacterial resistance, making it difficult to meet clinical infection prevention needs; second, the coating adhesion is insufficient, and antibacterial or functional components are easily detached, with significant performance degradation after repeated washing and poor durability; third, the functional integration is low, with most products only possessing basic compression functions and lacking deodorizing properties, leading to odors from sweat and bacterial metabolism during patient use, affecting the user experience; fourth, some products have poor substrate elasticity and insufficient fit, or the biosafety of the raw materials needs improvement, which may cause irritation with prolonged skin contact; fifth, some manufacturing process parameters are unreasonable, resulting in uneven dispersion of functional components and affecting product performance stability.

[0003] These issues collectively limit the clinical application effectiveness of medical pressure bands, necessitating the development of a multifunctional, highly stable, and well-adaptable medical pressure band. Summary of the Invention

[0004] The purpose of this invention is to provide a medical pressure band based on nylon-spandex elastic fleece and its preparation method, so as to solve the problems raised in the prior art.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a method for preparing a medical pressure band based on nylon-ammonia elastic fleece, comprising the following steps: S1: Quinoline-5-sulfonic acid, phthalonitrile, and metal salt are added to N,N-dimethylethanolamine and stirred evenly. 1,8-diazabicyclo[5.4.0]undec-7-ene is added, and the mixture is heated to 40-50℃ and reacted for 10-12 hours. Insoluble impurities are removed by filtration. The filtrate is distilled under reduced pressure, recrystallized by adding methanol, and dried under vacuum to obtain a water-soluble... Phthalocyanine dye; further, in the preparation process of the water-soluble phthalocyanine dye, the molar ratio of quinoline-5-sulfonic acid: phthalonitrile: metal salt is (4-6):(4-5):1; the amount of 1,8-diazabicyclo[5.4.0]undec-7-ene added is 8-12% of the mass of phthalonitrile; further, the metal salt includes any one of copper chloride or cobalt chloride; S2: Phthalic anhydride, monocarboxyl-substituted phthalic anhydride, and zinc chloride are added to nitrobenzene and heated to 17°C. React at 0-180℃ for 3-4 hours, cool to room temperature, filter and collect the product, wash the product sequentially with nitrobenzene and methanol until the washing solution is colorless, and vacuum dry to obtain monosubstituted β-carboxylated phthalocyanine zinc; furthermore, in the preparation process of the monosubstituted β-carboxylated phthalocyanine zinc, the molar ratio of phthalic anhydride to monocarboxylated phthalic anhydride is (3-4):1; the amount of zinc chloride added is 15-20% of the total mass of phthalic anhydride and monocarboxylated phthalic anhydride; S3: trimellitic anhydride, urea, ferric chloride are added. Add nitrobenzene and ammonium molybdate, heat to 160-170℃ and react for 3-4 hours, cool to room temperature, filter and collect the product, wash the product with methanol, then add the product to 50% potassium hydroxide solution, heat to 100-105℃ and hydrolyze for 24 hours, acidify the pH to 2-3, filter, wash and dry to obtain the iron phthalocyanine derivative; furthermore, in the preparation of the iron phthalocyanine derivative, the molar ratio of trimellitic anhydride, urea and ferric chloride is 1:(4-6):(0.25-0).3); The amount of ammonium molybdate added is 3-5% of the mass of trimellitic anhydride; S4: Immerse the nylon-ammonia elastic fleece in a sodium hydroxide solution with a concentration of 8-12wt% at 45-55℃ for 25-35 minutes, then immerse it in a hydrochloric acid solution with a concentration of 12-18wt% at room temperature for 15-25 minutes, wash with deionized water until the washing solution is neutral, and dry at 60-70℃ to obtain the pretreated nylon-ammonia elastic fleece; Further, the nylon-ammonia elastic fleece is made of 30D / 12F Nylon DTY and 30D / 1F Nylon FDY and 30D spandex are woven on a 32-needle single-needle bed warp knitting machine; specifications: weight 180-190 g / m2; S5: ε-polylysine is added to deionized water and stirred evenly to obtain an ε-polylysine solution; the pretreated nylon-spandex elastic fleece is immersed in the ε-polylysine solution, heated to 35-40℃ and stirred for 25-35 min to adsorption, then removed, washed with deionized water, and dried at 60-65℃ to obtain a nylon-spandex elastic fleece with an undercoat; furthermore, in the preparation process of the nylon-spandex elastic fleece with an undercoat, the concentration of the ε-polylysine solution is 500-1500. ppm; the bath ratio of pretreated nylon-amyl elastic fleece to ε-polylysine solution is 1:(15-25); S6: water-soluble phthalocyanine dye, monosubstituted β-carboxylated zinc phthalocyanine, and iron phthalocyanine derivative are mixed evenly to obtain composite phthalocyanine powder; the composite phthalocyanine powder is added to deionized water, and Pingping O is added, and ultrasonically dispersed to obtain a phthalocyanine dispersion with a concentration of 8-12 g / L; the pH of the phthalocyanine dispersion is adjusted to 4-5 using acetic acid, and then 2-3 wt% fatty alcohol polyoxyethylene ether is added and stirred evenly to obtain phthalocyanine composite slurry; furthermore, in the preparation process of the composite phthalocyanine powder, water-soluble phthalocyanine dye... Material: The mass ratio of monosubstituted β-carboxylated phthalocyanine zinc to iron phthalocyanine derivative is (4-6):(2-3):(1-2); the amount of Pingpingjia O added is 5-8% of the mass of the composite phthalocyanine powder; S7: Immerse the nylon-ammonia elastic fleece with the bottom coating into the phthalocyanine composite slurry, the bath ratio is 1:(20-30), heat to 95-105℃ for dyeing for 25-35min, take it out, rinse with deionized water, pre-dry at 60-70℃ for 10-15min, and cure at 100-110℃ for 1.5-2.5h to obtain the functional nylon-ammonia elastic fleece; flame melt the surface of the medical polyester foam and press the functional A nylon-spandex elastic fleece is used to obtain a medical pressure band; further, in the medical pressure band, the thickness of the ε-polylysine bottom coating is 10-20 μm and the thickness of the phthalocyanine composite functional layer is 20-30 μm; further, the thickness of the medical polyester foam is 2.3 mm and the density is 110 kg / m3; further, the thickness of the medical polyester foam melted on both sides during the flame melting process is 0.6-0.65 mm; further, the preparation method of the ε-polylysine includes the following steps: using glucose as a carbon source and ammonium sulfate as a nitrogen source, heating to 28-30℃ and pH=6 by Streptomyces.Fermentation was carried out for 72-96 hours (5-7 days). The fermentation broth was centrifuged to remove the bacterial cells. The supernatant was adsorbed and eluted through a cation exchange resin. The eluent was concentrated under reduced pressure and then freeze-dried to obtain ε-polylysine powder. Further, in the preparation of ε-polylysine, the glucose concentration was 20-30 g / L, and the ammonium sulfate concentration was 5-8 g / L.

[0006] Compared with the prior art, the beneficial effects of the present invention are as follows: 1. The present invention uses nylon-amylene elastic fleece pre-treatment with alkali washing and acid washing to remove surface impurities and increase active sites, providing a stable bonding basis for subsequent coatings, ensuring that the elasticity of the pressure band substrate is not damaged and the coating adhesion is significantly improved; using ε-polylysine as the bottom coating, it forms an electrostatic interaction with the bacterial cell membrane by means of cationic properties to destroy the membrane integrity, and at the same time forms covalent bonds with the upper phthalocyanine substances through amine groups, which not only achieves basic antibacterial effect against Gram-positive and Gram-negative bacteria, but also enhances the wash resistance and stability of the composite coating, and its biosafety ensures that there is no skin irritation in medical scenarios.

[0007] 2. In the composite phthalocyanine powder prepared by this invention, the water-soluble phthalocyanine dye forms ionic bonds with the substrate through substituents such as quinoline-5-sulfonic acid, thereby disrupting the bacterial metabolic enzyme system, achieving uniform staining and broad-spectrum antibacterial properties, while also exhibiting excellent wet fastness and light fastness; the monosubstituted β-carboxylated zinc phthalocyanine generates reactive oxygen species through photodynamic mechanisms under visible light irradiation, oxidizing and destroying bacterial biomolecules, effectively killing drug-resistant bacteria without easily inducing drug resistance; the iron phthalocyanine derivative, with its oxidase-like catalytic activity, decomposes odor substances through cyclic redox reactions, while synergistically enhancing the efficiency of reactive oxygen species generation, thus endowing the pressure belt with deodorizing function and antibacterial synergistic effect.

[0008] 3. This invention further improves the dispersibility of phthalocyanine components through the synergistic effect of additive Pingpingjia O and fatty alcohol polyoxyethylene ether, adjusts pH to promote the bonding between phthalocyanine and the substrate, and avoids damage to the substrate performance through gentle impregnation and curing processes. The three together ensure the uniformity of coating function. The chemical bonding between the substrate and the composite layer and the functional complementarity of the triphthalocyanine components form a synergistic effect, ultimately enabling the medical pressure band to integrate multiple functions such as antibacterial, deodorizing, dyeing, and elastic adhesion, and has good durability, stability and biocompatibility, making it suitable for clinical infection prevention, postoperative care and other scenarios. Attached Figure Description

[0009] Figure 1 is a schematic diagram of the structure of the medical pressure belt of the present invention; Figure 2 is a schematic diagram of the actual medical pressure belt of the present invention; Figure 3 is a schematic diagram of the structure of the nylon-spandex elastic fleece of the present invention. Detailed Implementation

[0010] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0011] In the following examples, the preparation method of water-soluble phthalocyanine dye includes the following steps: quinoline-5-sulfonic acid, phthalonitrile, and copper chloride are added to N,N-dimethylethanolamine and stirred evenly. Then, 1,8-diazabicyclo[5.4.0]undec-7-ene is added, and the mixture is heated to 45°C and reacted for 11 hours. Insoluble impurities are removed by filtration. The filtrate is then distilled under reduced pressure, recrystallized with methanol, and dried under vacuum to obtain water-soluble phthalocyanine dye. During the preparation of the water-soluble phthalocyanine dye, the molar ratio of quinoline-5-sulfonic acid:phthalonitrile:metal salt is 4:4:1; 1,8-diazabicyclo[5.4.0]undec-7-ene... The amount of C-7-ene added is 8% of the mass of phthalonitrile; the preparation method of monosubstituted β-carboxylated phthalocyanine zinc includes the following steps: phthalic anhydride, monocarboxylated phthalic anhydride, and zinc chloride are added to nitrobenzene, heated to 175℃ and reacted for 3.5 h, cooled to room temperature, the product is collected by filtration, and the product is washed successively with nitrobenzene and methanol until the washing liquid is colorless, and dried under vacuum to obtain monosubstituted β-carboxylated phthalocyanine zinc; in the preparation of monosubstituted β-carboxylated phthalocyanine zinc, the molar ratio of phthalic anhydride to monocarboxylated phthalic anhydride is 3:1; the amount of zinc chloride added is 15% of the total mass of phthalic anhydride and monocarboxylated phthalic anhydride.

[0012] The preparation method of iron phthalocyanine derivative includes the following steps: adding trimellitic anhydride, urea, and ferric chloride to nitrobenzene, adding ammonium molybdate, heating to 165℃ and reacting for 3.5 h, cooling to room temperature, filtering and collecting the product, washing the product with methanol, then adding the product to 50% potassium hydroxide solution, heating to 100℃ and hydrolyzing for 24 h, acidifying the pH to 2, filtering, washing, and drying to obtain the iron phthalocyanine derivative; in the preparation of the iron phthalocyanine derivative, the molar ratio of trimellitic anhydride, urea, and ferric chloride is 1:4:0.25; the amount of ammonium molybdate added is 3% of the mass of trimellitic anhydride.

[0013] The preparation method of ε-polylysine includes the following steps: using glucose as a carbon source and ammonium sulfate as a nitrogen source, Streptomyces is heated to 28℃ and pH=6.5 and fermented for 72h. The fermentation broth is centrifuged to remove the bacterial cells. The supernatant is adsorbed and eluted through a cation exchange resin. The eluent is concentrated under reduced pressure and then freeze-dried to obtain ε-polylysine powder. In the preparation of ε-polylysine, the glucose concentration is 20g / L and the ammonium sulfate concentration is 5g / L.

[0014] Example 1: A method for preparing a medical pressure band based on nylon-amylene elastic fleece, comprising the following steps: S1: Immersing the nylon-amylene elastic fleece in a 50°C, 8wt% sodium hydroxide solution for 25 min, then immersing it in a 12wt% hydrochloric acid solution at room temperature for 15 min, washing with deionized water until the washing solution is neutral, and drying at 60°C to obtain a pretreated nylon-amylene elastic fleece; S2: Adding ε-polylysine to deionized water and stirring evenly to obtain a 1000ppm ε-polylysine solution; immersing the pretreated nylon-amylene elastic fleece in the ε-polylysine solution, heating to 35°C and stirring for adsorption, removing it, washing with deionized water, and drying to obtain a nylon-amylene elastic fleece with an undercoat; S3: Mixing water-soluble phthalocyanine dye, monosubstituted β-carboxylated zinc phthalocyanine, and iron phthalocyanine derivative evenly. The composite phthalocyanine powder was obtained by uniform mixing. The composite phthalocyanine powder was added to deionized water, and 6 wt% of a certain amount ...

[0015] In the medical pressure band, the thickness of the ε-polylysine bottom coating is 15μm and the thickness of the phthalocyanine composite functional layer is 25μm.

[0016] Example 2: A method for preparing a medical pressure band based on nylon-amylene elastic fleece, comprising the following steps: S1: Immersing the nylon-amylene elastic fleece in a 50°C, 8wt% sodium hydroxide solution for 25 min, then immersing it in a 12wt% hydrochloric acid solution at room temperature for 15 min, washing with deionized water until the washing solution is neutral, and drying at 60°C to obtain a pretreated nylon-amylene elastic fleece; S2: Adding ε-polylysine to deionized water and stirring evenly to obtain a 1500ppm ε-polylysine solution; immersing the pretreated nylon-amylene elastic fleece in the ε-polylysine solution, heating to 35°C and stirring for adsorption, removing it, washing with deionized water, and drying to obtain a nylon-amylene elastic fleece with an undercoat; S3: Adding water-soluble phthalocyanine dye, monosubstituted β-carboxylated zinc phthalocyanine, and iron phthalocyanine derivatives... The mixture was thoroughly mixed to obtain a composite phthalocyanine powder. The composite phthalocyanine powder was added to deionized water, and 8wt% of Pingpingjia O was added. The mixture was ultrasonically dispersed to obtain a 12g / L phthalocyanine dispersion. The pH of the phthalocyanine dispersion was adjusted to 4, and then 3wt% of fatty alcohol polyoxyethylene ether was added. The mixture was stirred thoroughly to obtain a phthalocyanine composite slurry. In the composite phthalocyanine powder, the mass ratio of water-soluble phthalocyanine dye: monosubstituted β-carboxylated phthalocyanine zinc: iron phthalocyanine derivative was 6:3:2. S4: The nylon-ammonia elastic fleece with a bottom coating was immersed in the phthalocyanine composite slurry at a bath ratio of 1:25 and dyed at 105℃. The fleece was removed, rinsed with deionized water, pre-dried at 70℃ for 12min, and cured at 110℃ for 2h to obtain a functional nylon-ammonia elastic fleece. The surface of the medical polyester foam was flame-melted and pressed onto the functional nylon-ammonia elastic fleece to obtain a medical pressure band.

[0017] In the medical pressure band, the thickness of the ε-polylysine bottom coating is 20μm and the thickness of the phthalocyanine composite functional layer is 30μm.

[0018] Example 3: A method for preparing a medical pressure band based on nylon-amylene elastic fleece, comprising the following steps: S1: Immersing the nylon-amylene elastic fleece in a 50°C, 8wt% sodium hydroxide solution for 25 min, then immersing it in a 12wt% hydrochloric acid solution at room temperature for 15 min, washing with deionized water until the washing solution is neutral, and drying at 60°C to obtain a pretreated nylon-amylene elastic fleece; S2: Adding ε-polylysine to deionized water and stirring evenly to obtain a 500ppm ε-polylysine solution; immersing the pretreated nylon-amylene elastic fleece in the ε-polylysine solution, heating to 35°C and stirring for adsorption, removing it, washing with deionized water, and drying to obtain a nylon-amylene elastic fleece with an undercoat; S3: Adding water-soluble phthalocyanine dye, monosubstituted β-carboxyphthalocyanine zinc, and iron phthalocyanine derivatives... The materials were mixed evenly to obtain composite phthalocyanine powder; the composite phthalocyanine powder was added to deionized water, 5wt% of phthalocyanine oxide was added, and ultrasonic dispersion was performed to obtain an 8g / L phthalocyanine dispersion; the pH of the phthalocyanine dispersion was adjusted to 4, and then 2wt% of fatty alcohol polyoxyethylene ether was added and stirred evenly to obtain phthalocyanine composite slurry; in the composite phthalocyanine powder, the mass ratio of water-soluble phthalocyanine dye: monosubstituted β-carboxylated phthalocyanine zinc: iron phthalocyanine derivative was 4:2:1; S4: The nylon-ammonia elastic fleece with a bottom coating was immersed in the phthalocyanine composite slurry at a bath ratio of 1:20 and dyed at 95℃. After immersion, it was taken out, rinsed with deionized water, pre-dried at 60℃ for 12min, and cured at 100℃ for 2h to obtain functional nylon-ammonia elastic fleece; the surface of medical polyester foam was flame-melted and pressed with functional nylon-ammonia elastic fleece to obtain a medical pressure band.

[0019] In the medical pressure band, the thickness of the ε-polylysine bottom coating is 10μm and the thickness of the phthalocyanine composite functional layer is 20μm.

[0020] Comparative Example 1: A method for preparing a medical pressure band based on nylon-amylene elastic fleece, comprising the following steps: S1: Immersing the nylon-amylene elastic fleece in a 50°C, 8wt% sodium hydroxide solution for 25 min, then immersing it in a 12wt% hydrochloric acid solution at room temperature for 15 min, washing with deionized water until the washing solution is neutral, and drying at 60°C to obtain a pretreated nylon-amylene elastic fleece; S2: Adding ε-polylysine to deionized water and stirring evenly to obtain a 1000ppm ε-polylysine solution; immersing the pretreated nylon-amylene elastic fleece in the ε-polylysine solution, heating to 35°C and stirring for adsorption, removing it, washing with deionized water, and drying to obtain a nylon-amylene elastic fleece with an undercoat; S3: Mixing water-soluble phthalocyanine dye and monosubstituted β-carboxylated zinc phthalocyanine... The composite phthalocyanine powder was obtained by mixing the powder evenly with water. The powder was then added to deionized water, and 6 wt% of a certain amount ...

[0021] In the medical pressure band, the thickness of the ε-polylysine bottom coating is 15μm and the thickness of the phthalocyanine composite functional layer is 25μm.

[0022] Comparative Example 2: A method for preparing a medical pressure band based on nylon-amylene elastic fleece, comprising the following steps: S1: Immersing the nylon-amylene elastic fleece in a 50°C, 8wt% sodium hydroxide solution for 25 min, then immersing it in a 12wt% hydrochloric acid solution at room temperature for 15 min, washing with deionized water until the washing solution is neutral, and drying at 60°C to obtain a pretreated nylon-amylene elastic fleece; S2: Adding ε-polylysine to deionized water and stirring evenly to obtain a 1000ppm ε-polylysine solution; immersing the pretreated nylon-amylene elastic fleece in the ε-polylysine solution, heating to 35°C and stirring for adsorption, removing it, washing with deionized water, and drying to obtain a nylon-amylene elastic fleece with an undercoat; S3: Mixing water-soluble phthalocyanine dye and iron phthalocyanine derivative... The composite phthalocyanine powder was obtained by uniform mixing. The composite phthalocyanine powder was added to deionized water, and 6wt% of phthalocyanine oxide was added. The mixture was ultrasonically dispersed to obtain a 10g / L phthalocyanine dispersion. The pH of the phthalocyanine dispersion was adjusted to 4, and 2.5wt% of fatty alcohol polyoxyethylene ether was added. The mixture was stirred evenly to obtain a phthalocyanine composite slurry. The mass ratio of water-soluble phthalocyanine dye to iron phthalocyanine derivative in the composite phthalocyanine powder was 5:1.5. S4: The nylon-spandex elastic fleece with a bottom coating was immersed in the phthalocyanine composite slurry at a bath ratio of 1:25 and dyed at 100℃. The fleece was removed, rinsed with deionized water, pre-dried at 65℃ for 12min, and cured at 105℃ for 2h to obtain a functional nylon-spandex elastic fleece. The surface of the medical polyester foam was flame-melted and pressed with the functional nylon-spandex elastic fleece to obtain a medical pressure band.

[0023] In the medical pressure band, the thickness of the ε-polylysine bottom coating is 15μm and the thickness of the phthalocyanine composite functional layer is 25μm.

[0024] Comparative Example 3: A method for preparing a medical pressure band based on nylon-amylene elastic fleece, comprising the following steps: S1: Immersing the nylon-amylene elastic fleece in a 50°C, 8wt% sodium hydroxide solution for 25 min, then immersing it in a 12wt% hydrochloric acid solution at room temperature for 15 min, washing with deionized water until the washing solution is neutral, and drying at 60°C to obtain pretreated nylon-amylene elastic fleece; S2: Adding ε-polylysine to deionized water and stirring evenly to obtain a 1000ppm ε-polylysine solution; immersing the pretreated nylon-amylene elastic fleece in the ε-polylysine solution, heating to 35°C with stirring for adsorption, removing it, washing with deionized water, and drying to obtain... S3: Add water-soluble phthalocyanine dye to deionized water, add 6wt% phthalocyanine oxide, and ultrasonically disperse to obtain a 10g / L phthalocyanine dispersion; adjust the pH of the phthalocyanine dispersion to 4, then add 2.5wt% fatty alcohol polyoxyethylene ether, stir evenly to obtain a phthalocyanine composite slurry; S4: Immerse the phthalocyanine-spandex elastic fleece with the undercoat into the phthalocyanine composite slurry at a bath ratio of 1:25, dye at 100℃, remove, rinse with deionized water, pre-dry at 65℃ for 12min, and cure at 105℃ for 2h to obtain a functional phthalocyanine-spandex elastic fleece; flame melt the surface of medical polyester foam and press the functional phthalocyanine-spandex elastic fleece to obtain a medical pressure band.

[0025] In the medical pressure band, the thickness of the ε-polylysine bottom coating is 15μm and the thickness of the phthalocyanine composite functional layer is 25μm.

[0026] Comparative Example 4: A method for preparing a medical pressure band based on nylon-amylene elastic fleece, comprising the following steps: S1: Immersing the nylon-amylene elastic fleece in a 50°C, 8wt% sodium hydroxide solution for 25 min, then immersing it in a 12wt% hydrochloric acid solution at room temperature for 15 min, washing with deionized water until the washing solution is neutral, and drying at 60°C to obtain pretreated nylon-amylene elastic fleece; S2: Mixing water-soluble phthalocyanine dye, monosubstituted β-carboxylated zinc phthalocyanine, and iron phthalocyanine derivative uniformly to obtain composite phthalocyanine powder; adding the composite phthalocyanine powder to deionized water, adding 6wt% phthalocyanine oxide, and ultrasonically dispersing to obtain 10 g / L phthalocyanine. Dispersion; Adjust the pH of the phthalocyanine dispersion to 4, then add 2.5 wt% fatty alcohol polyoxyethylene ether, stir evenly to obtain phthalocyanine composite slurry; In the composite phthalocyanine powder, the mass ratio of water-soluble phthalocyanine dye: monosubstituted β-carboxylated phthalocyanine zinc: iron phthalocyanine derivative is 5:2.5:1.5; S3: Immerse the pretreated nylon-amylene elastic fleece in the phthalocyanine composite slurry at a bath ratio of 1:25, dye at 100℃, take it out, rinse with deionized water, pre-dry at 65℃ for 12 min, and cure at 105℃ for 2 h to obtain functional nylon-amylene elastic fleece; Flame melt the surface of medical polyester foam and press the functional nylon-amylene elastic fleece to obtain a medical pressure band.

[0027] In the medical pressure band, the thickness of the ε-polylysine bottom coating is 15μm and the thickness of the phthalocyanine composite functional layer is 25μm.

[0028] Comparative Example 5: A method for preparing a medical pressure band based on nylon-amylene elastic fleece, comprising the following steps: S1: Immersing the nylon-amylene elastic fleece in a 50°C, 8wt% sodium hydroxide solution for 25 min, then immersing it in a 12wt% hydrochloric acid solution at room temperature for 15 min, washing with deionized water until the washing solution is neutral, and drying at 60°C to obtain a pretreated nylon-amylene elastic fleece; S2: Adding ε-polylysine to deionized water and stirring evenly to obtain a 300ppm ε-polylysine solution; immersing the pretreated nylon-amylene elastic fleece in the ε-polylysine solution, heating to 35°C and stirring for adsorption, removing it, washing with deionized water, and drying to obtain a nylon-amylene elastic fleece with an undercoat; S3: Mixing water-soluble phthalocyanine dye, monosubstituted β-carboxylated zinc phthalocyanine, and iron phthalocyanine derivative evenly. The composite phthalocyanine powder was obtained by uniform mixing. The composite phthalocyanine powder was added to deionized water, and 6 wt% of a certain amount ...

[0029] In the medical pressure band, the thickness of the ε-polylysine bottom coating is 15μm and the thickness of the phthalocyanine composite functional layer is 25μm.

[0030] The medical pressure band prepared in Example 1 was used as the final sample; the functional nylon-spandex elastic fleece and the medical pressure band were sent for testing separately, and the elasticity test was carried out according to British Standard BS7505; the test data are shown in Table 1 below.

[0031] Table 1 Test Data of Medical Compression Bands Performance testing: Antibacterial performance: The SpreadPlate method was used, with an inoculum concentration of 107-108 CFU / mL and light conditions of 700nm and 150mW / cm2, to calculate the bactericidal rate.

[0032] Deodorization performance: The medical pressure belt was soaked in 0.1% 2-mercaptoethanol solution for 2 hours, the residual concentration was detected by HPLC, and the oxidation decomposition rate was calculated.

[0033] Coating adhesion and durability: 50 ultrasonic washes at 60℃ (30 min each time) were performed to test the retention rate of antibacterial / deodorizing properties after washing.

[0034] Elasticity retention rate: The elongation at break was tested using a universal testing machine, and the elasticity retention rate compared with the untreated substrate was calculated.

[0035] Biocompatibility: Skin irritation test was conducted in accordance with GB / T16886.10-2017.

[0036] The test results are shown in Table 2 below.

[0037] Table 2 Performance Test Data of Medical Pressure Bands Conclusion: The medical pressure band prepared by this invention is significantly superior to the comparative method that lacks core components or changes key parameters in terms of antibacterial properties, deodorization, coating adhesion, elasticity retention, and biosafety. It effectively solves the problems of existing medical pressure bands, such as limited antibacterial properties, poor durability, and insufficient functionality, and is suitable for clinical infection prevention, postoperative care, and other scenarios.

[0038] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within the present invention.

Claims

1. A method for preparing a medical pressure band based on nylon-spandex elastic fleece, characterized in that: Includes the following steps: S1: Pre-treat the nylon-spandex elastic fleece fabric and set aside; Add ε-polylysine to deionized water and stir until homogeneous to obtain an ε-polylysine solution; The pretreated nylon-polyurethane elastic fleece was immersed in an ε-polylysine solution, heated to 35-40℃ and stirred for adsorption, then removed, washed with deionized water, and dried to obtain a nylon-polyurethane elastic fleece with an undercoat. S2: Water-soluble phthalocyanine dye, monosubstituted β-carboxylated zinc phthalocyanine, and iron phthalocyanine derivative are mixed evenly to obtain composite phthalocyanine powder; the composite phthalocyanine powder is added to deionized water, and Pingping O is added, followed by ultrasonic dispersion to obtain phthalocyanine dispersion; the pH of the phthalocyanine dispersion is adjusted to 4-5, and then fatty alcohol polyoxyethylene ether is added and stirred evenly to obtain phthalocyanine composite slurry; S3: A nylon-spandex elastic fleece with a bottom coating is immersed in the phthalocyanine composite slurry, dyed, removed, rinsed with deionized water, pre-dried, and cured to obtain functional nylon-spandex elastic fleece; the surface of medical polyester foam is flame-melted and pressed onto the functional nylon-spandex elastic fleece to obtain a medical pressure band.

2. The method for preparing a medical pressure band based on nylon-spandex elastic fleece according to claim 1, characterized in that: The pretreatment process of the nylon-spandex elastic fleece includes the following steps: immersing the nylon-spandex elastic fleece in a sodium hydroxide solution with a concentration of 8-12 wt% at 45-55℃ for 25-35 minutes, then immersing it in a hydrochloric acid solution with a concentration of 12-18 wt% at room temperature for 15-25 minutes, washing it with deionized water until the washing solution is neutral, and drying it at 60-70℃ to obtain the pretreated nylon-spandex elastic fleece.

3. The method for preparing a medical pressure band based on nylon-spandex elastic fleece according to claim 1, characterized in that: In the preparation of nylon-spandex elastic fleece with a base coating, the concentration of ε-polylysine solution is 500-1500 ppm; the bath ratio of pretreated nylon-spandex elastic fleece to ε-polylysine solution is 1:(15-25).

4. The method for preparing a medical pressure band based on nylon-spandex elastic fleece according to claim 1, characterized in that: In the preparation of composite phthalocyanine powder, the mass ratio of water-soluble phthalocyanine dye: monosubstituted β-carboxylated phthalocyanine zinc: iron phthalocyanine derivative is (4-6):(2-3):(1-2); the amount of Pingpingjia O added is 5-8% of the mass of composite phthalocyanine powder; the concentration of the phthalocyanine dispersion is 8-12 g / L; and the amount of fatty alcohol polyoxyethylene ether added is 2-3% of the mass of composite phthalocyanine powder.

5. The method for preparing a medical pressure band based on nylon-spandex elastic fleece according to claim 1, characterized in that: During the dyeing process, the liquor ratio is 1:(20-30), the temperature is 95-105℃, the pre-drying temperature is 60-70℃, and the curing temperature is 100-110℃.

6. The method for preparing a medical pressure band based on nylon-spandex elastic fleece according to claim 1, characterized in that: The method for preparing the water-soluble phthalocyanine dye includes the following steps: adding quinoline-5-sulfonic acid, phthalonitrile, and a metal salt to N,N-dimethylethanolamine, stirring until homogeneous, adding 1,8-diazabicyclo[5.4.0]undec-7-ene, heating to 40-50℃ and reacting for 10-12 hours, filtering to remove insoluble impurities, distilling the filtrate under reduced pressure, adding methanol for recrystallization, and drying under vacuum to obtain the water-soluble phthalocyanine dye; in the preparation of the water-soluble phthalocyanine dye, the molar ratio of quinoline-5-sulfonic acid: phthalonitrile: metal salt is (4-6):(4-5):1; the amount of 1,8-diazabicyclo[5.4.0]undec-7-ene added is 8-12% of the mass of phthalonitrile; the metal salt includes any one of copper chloride or cobalt chloride.

7. The method for preparing a medical pressure band based on nylon-spandex elastic fleece according to claim 1, characterized in that: The preparation method of the monosubstituted β-carboxylated phthalocyanine zinc includes the following steps: adding phthalic anhydride, monocarboxylated phthalic anhydride, and zinc chloride to nitrobenzene, heating to 170-180℃ for 3-4 hours, cooling to room temperature, filtering and collecting the product, washing the product sequentially with nitrobenzene and methanol until the washing solution is colorless, and vacuum drying to obtain monosubstituted β-carboxylated phthalocyanine zinc; in the preparation process of monosubstituted β-carboxylated phthalocyanine zinc, the molar ratio of phthalic anhydride to monocarboxylated phthalic anhydride is (3-4):1; the amount of zinc chloride added is 15-20% of the total mass of phthalic anhydride and monocarboxylated phthalic anhydride.

8. The method for preparing a medical pressure band based on nylon-spandex elastic fleece according to claim 1, characterized in that: The preparation method of the iron phthalocyanine derivative includes the following steps: adding trimellitic anhydride, urea, and ferric chloride to nitrobenzene, adding ammonium molybdate, heating to 160-170℃ for 3-4 hours, cooling to room temperature, filtering to collect the product, washing the product with methanol, adding the product to 50% potassium hydroxide solution, heating to 100-105℃ for 24 hours for hydrolysis, acidifying the pH to 2-3, filtering, washing, and drying to obtain the iron phthalocyanine derivative; in the preparation of the iron phthalocyanine derivative, the molar ratio of trimellitic anhydride, urea, and ferric chloride is 1:(4-6):(0.25-0.3); the amount of ammonium molybdate added is 3-5% of the mass of trimellitic anhydride.

9. A medical pressure band prepared by the method of preparing a medical pressure band based on nylon-ammonia elastic fleece according to any one of claims 1-8.

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