Raw material pretreatment stirring and mixing device for compound dibazol hydrochlorothiazide capsules

Abstract

The invention relates to the technical field of particle raw material stirring and mixing, in particular to a compound dibazol hydrochlorothiazide capsule raw material pretreatment stirring and mixing device which comprises a plurality of treatment frames which are evenly distributed from top to bottom and provided with upward openings, discharging openings are formed in the bottoms of the treatment frames, and stirring mechanisms are installed in the treatment frames; the device adopts a manner of matching layered laying and alternate stacking, active ingredients are independently stirred and flattened, then the active ingredients and auxiliary materials are stacked layer by layer, the active ingredients are uniformly attached to the surfaces of the auxiliary materials through throwing, and multi-stage gradual dilution is carried out, so that the problem that the active ingredients are easy to disperse and non-uniform when being directly mixed can be solved, the medicine content accuracy is improved, and the medicine quality is improved. And the components of each capsule are uniform and reach the standard.

Description

Technical Field

[0001] This invention relates to the technical field of mixing granular raw materials, and in particular to a mixing apparatus for the pretreatment of raw materials for compound dibazol hydrochlorothiazide capsules. Background Technology

[0002] In the pharmaceutical industry, compound dibazol hydrochlorothiazide capsules are a commonly used drug for treating hypertension. It is composed of the main active ingredient dibazol (a granular vasodilator used to lower blood pressure and improve cerebral blood circulation) and hydrochlorothiazide (a granular diuretic used to promote the excretion of excess salt and water from the body, thereby lowering blood pressure). During the pharmaceutical process, excipients are often added during the mixing of the raw materials to facilitate the formation of stable capsules.

[0003] Traditional mixing methods involve using existing equipment to uniformly stir and mix all the raw materials used to make compound dibazol hydrochlorothiazide capsules. For example, patent application CN205760725U discloses a particle mixing and stirring device. A first guide plate is fixedly installed at the upper end of the material cylinder, and a first stirring roller group containing two parallel stirring rollers is rotatably installed below it. A second guide plate is fixedly installed below the first stirring roller group, and a second stirring roller group with the same structure as the first stirring roller group is rotatably installed below it. A third stirring roller group containing two coaxial stirring rollers is rotatably installed below the second stirring roller group. When the material flows from the feed port at the upper end of the material cylinder to the discharge port at the bottom, it is mixed five times, resulting in uniform and thorough mixing, saving labor and improving work efficiency.

[0004] In the production process of compound dibazol hydrochlorothiazide capsules, the actual proportion of active ingredients is usually low, while the main body is composed of various excipients to ensure capsule formation and stability. The above-mentioned uniform mixing process requires all raw materials to be put into the mixing cylinder at one time for stirring, which will have the following problems: First, since the two active ingredients have a limited proportion in the total material, when they are directly mixed with a large number of excipients, it is very easy to have uneven dispersion of components. Although the device performs multiple mixing through a five-stage series stirring structure, the mixing method at each stage is basically the same, making it difficult to finely disperse according to the characteristics of different materials and failing to ensure the accuracy of drug content in each capsule.

[0005] Secondly, the active ingredients and excipients have significant differences in physical properties, such as particle size distribution, density, and surface properties. During uniform mixing, these differences can cause the materials to separate due to vibration and flow, resulting in quality fluctuations between different capsules in the same production batch, which directly affects the uniformity of the product and the safety of treatment.

[0006] Based on this, as stated above, there is still room for improvement in the existing technology for the pretreatment and mixing of raw materials for compound dibazol hydrochlorothiazide capsules. Summary of the Invention

[0007] In order to solve the technical problems existing in the prior art, the present invention provides a mixing and stirring device for pretreatment of raw materials of compound dibazol hydrochlorothiazide capsules.

[0008] To achieve the above objectives, the present invention provides the following technical solution: a pretreatment stirring and mixing device for compound dibazol hydrochlorothiazide capsule raw materials, comprising multiple processing frames evenly distributed from top to bottom with upward openings, a discharge port at the bottom of the processing frame, and a stirring mechanism installed inside the processing frame.

[0009] It also includes multiple ring frames that mate with the processing frame, with the processing frame rotatably mounted inside the ring frame.

[0010] Support frames are arranged symmetrically along the radial direction of the processing frame, and the ring frame is installed on the support frame on the corresponding side through a connecting plate.

[0011] The stirring mechanism includes a rotating shaft that is rotatably mounted at the bottom center of the processing frame via a bearing. A stirring frame is mounted on the rotating shaft, and multiple stirring rods are evenly installed along the length of the bottom of the stirring frame.

[0012] A lifting frame that can move up and down is slidably mounted on the rotating shaft. The stirring rod passes through the lifting frame, and a scraper is installed at the bottom of the lifting frame between two adjacent stirring rods.

[0013] A linkage rod is installed on the top of the lifting frame. The top of the linkage rod passes through the corresponding mixing frame and is equipped with a bending structure. A continuous spiral rod is installed on the inner wall of the processing frame, and the bending structure is attached to the spiral rod.

[0014] Preferably, an extension frame is mounted on the annular frame, and a drive shaft is rotatably mounted on the extension frame via bearings, with gears mounted on the drive shaft.

[0015] The processing frame is equipped with an annular rack plate that meshes with the corresponding gear. The drive shaft can drive the processing frame to rotate through the meshing of the gear and the annular rack plate, and the rotation direction of the processing frame is opposite to the rotation direction of the rotating shaft.

[0016] Preferably, a lifting rod is slidably provided through the connecting plate corresponding to any of the support frames, a linkage rod is installed on the top of the lifting rod, a lifting cylinder is installed on the connecting plate, and the extension end of the lifting cylinder is connected to the corresponding linkage rod.

[0017] The lifting rod is equipped with a fixing plate that corresponds to each processing frame. The fixing plate is equipped with an annular plate that is coaxial with the corresponding processing frame. The inner side wall of the annular plate is provided with an annular groove.

[0018] Preferably, the bottom of the discharge port is provided with a sealing plate for opening and closing. The sealing plate is connected to the bottom of the corresponding processing frame through a telescopic spring rod, and the sealing plate is limited and slidably disposed inside the annular groove.

[0019] The lifting cylinder can drive the sealing plate to move up and down to open and close the discharge port.

[0020] Preferably, the top of the sealing plate is configured as a horizontally placed triangular prism structure, and multiple insertion rods are evenly arranged thereon.

[0021] The lifting cylinder can drive the connecting plate to move up and down repeatedly through the lifting rod and the linkage rod, thereby driving the sealing plate to move up and down repeatedly. The insertion rod can loosen the raw material near the discharge port.

[0022] Preferably, the bending structure can slide along the helical rod when it rotates with the rotating shaft, and under the limiting action of the helical rod, it drives the lifting frame to move upward synchronously.

[0023] When the bent structure moves to the extreme position at the top of the auger, it can slide naturally down the guide slope of the auger to the second to last section of the auger, and continue to rotate with the rotating shaft to repeat the lifting and lowering action.

[0024] Preferably, another support frame is provided with a transmission mechanism between two adjacent processing frames. The transmission mechanism includes fixed frames symmetrically arranged along the length of the support frame. A transmission shaft is rotatably mounted between the fixed frames via bearings. The transmission shaft is connected to the corresponding rotating shafts of the two adjacent processing frames via belt drive.

[0025] Preferably, the pulley near the upper part of the circumferential surface of the drive shaft is designated as pulley one, the pulleys that are sleeved on one end of all rotating shafts facing each other are designated as pulley two, and the pulley sleeved on the bottom of the drive shaft is designated as pulley three. The diameter of pulley one is larger than the diameter of pulley two, and the diameter of pulley two is equal to the diameter of pulley three, so that the rotational speed of the rotating shafts distributed from top to bottom gradually decreases.

[0026] Preferably, during material feeding, the rotation of the processing frame can drive the lifting frame to move downward through the cooperation of the spiral rod and the bending structure. The stirring rod remains in a rotating state relative to the processing frame, and the downward movement of the lifting frame can scrape the raw material towards the recessed area of ​​the discharge port.

[0027] Preferably, the bending structure can scrape off the raw material adhering to the screw rod during its movement on the screw rod.

[0028] The raw materials poured into the processing frame should always be located below the mixing rack and kept at a distance from the mixing rack to avoid obstructing the normal circumferential rotation of the mixing rod.

[0029] Compared with the prior art, the present invention provides a mixing and stirring device for pretreatment of raw materials for compound dibazol hydrochlorothiazide capsules, which has the following beneficial effects: (1) The device adopts a combination of layered laying and alternating stacking. First, the active ingredient is stirred and leveled separately, and then it is stacked with the excipients layer by layer. By sprinkling, the active ingredient is evenly attached to the surface of the excipients. Through multi-stage gradual dilution, the problem of uneven dispersion caused by direct mixing of active ingredients can be solved, the accuracy of drug content can be improved, and the uniformity of the ingredients in each capsule can be ensured.

[0030] (2) During the stirring process, the scraper adapts to level the active ingredients, ensuring that the material is evenly distributed. When feeding, the processing frame and the stirring rod rotate in opposite directions, and the scraper keeps the material flowing. This can effectively reduce the mixing and stratification caused by differences in the particle size of active ingredients and excipients, reduce the quality fluctuation of capsules within batches, and ensure product uniformity and therapeutic safety.

[0031] (3) The rotation speed of the rotating shaft decreases gradually from top to bottom to adapt to the scenario where the amount of raw materials in the lower processing frame increases, reduce the stirring resistance of the stirring rod, and avoid the stirring rod from getting stuck or seizing. Attached Figure Description

[0032] The accompanying drawings are provided to further illustrate the invention and form part of the specification. They are used together with the embodiments of the invention to explain the invention, but do not constitute a limitation thereof. In the drawings: Figure 1 This is a three-dimensional structural schematic diagram of the present invention.

[0033] Figure 2 This is a three-dimensional installation structure diagram of the stirring rack, stirring rod, and processing frame of the present invention.

[0034] Figure 3 This is a schematic diagram of the internal three-dimensional structure of the processing frame of the present invention.

[0035] Figure 4 This is the present invention. Figure 3 A magnified view of part A.

[0036] Figure 5 This is a three-dimensional installation structure diagram of the support frame, connecting plate, lifting rod, and annular plate of the present invention.

[0037] Figure 6 This is the present invention. Figure 5 A magnified view of section B.

[0038] Figure 7 This is a schematic diagram of the discharge port of the present invention changing from closed to open.

[0039] Figure 8 This is a schematic diagram of the three-dimensional installation structure between the spiral rod, bending structure, and processing frame of the present invention.

[0040] Figure 9 This is a three-dimensional structural diagram of the transmission mechanism of the present invention.

[0041] Explanation of reference numerals in the attached drawings: 1. Processing frame; 11. Discharge port; 2. Stirring mechanism; 21. Rotating shaft; 211. Pulley 2; 22. Stirring frame; 23. Stirring rod; 24. Lifting frame; 241. Linkage rod; 242. Spiral rod; 25. Scraper; 3. Annular frame; 31. Extending frame; 32. Drive shaft; 33. Gear; 34. Annular rack plate; 4. Support frame; 41. Connecting plate; 42. Lifting rod; 43. Linkage rod; 44. Lifting cylinder; 45. Fixing plate; 46. Annular plate; 47. Sealing plate; 471. Insertion rod; 5. Transmission mechanism; 51. Fixed frame; 52. Transmission shaft; 521. Pulley 1; 522. Pulley 3. Detailed Implementation

[0042] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The components of the embodiments of the present invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations. Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0043] This embodiment proposes a pretreatment stirring and mixing device for compound dibazol hydrochlorothiazide capsule raw materials, such as... Figure 1-9 As shown, it includes multiple processing frames 1 evenly distributed from top to bottom with upward openings. The bottom of the processing frame 1 has a discharge port 11. A stirring mechanism 2 is installed inside the processing frame 1. Multiple ring frames 3 are also provided to cooperate with the processing frame 1 one by one. The processing frame 1 is rotatably installed inside the ring frame 3. Support frames 4 are symmetrically arranged radially along the processing frame 1. The ring frames 3 are installed on the support frames 4 on the corresponding side through connecting plates 41.

[0044] The stirring mechanism 2 includes a rotating shaft 21 that is rotatably mounted in the middle of the bottom of the processing frame 1 via a bearing. A stirring frame 22 is mounted on the rotating shaft 21. Multiple stirring rods 23 are evenly mounted on the bottom of the stirring frame 22 along its length. A lifting frame 24 that moves up and down is slidably mounted on the rotating shaft 21. The stirring rods 23 pass through the lifting frame 24. A scraper 25 is installed at the bottom of the lifting frame 24 and between two adjacent stirring rods 23.

[0045] In actual operation, an external motor (not shown in the figure) drives the uppermost rotating shaft 21 to rotate via belt drive. The active ingredients that make up the compound dibazol hydrochlorothiazide capsules are slowly poured into the uppermost processing frame 1, which drives the corresponding rotating shaft 21 to rotate. During the rotation of the rotating shaft 21, the stirring rod 23 is driven to rotate around the rotating shaft 21 axially via the stirring frame 22. The stirring rod 23 mixes and stirs the active ingredients.

[0046] A linkage rod 241 is installed on the top of the lifting frame 24. The top of the linkage rod 241 passes through the corresponding stirring frame 22 and is provided with a bending structure. A continuous spiral rod 242 is provided on the inner wall of the processing frame 1, and the bending structure is attached to the spiral rod 242.

[0047] During the above stirring process, the rotating shaft 21 rotates synchronously, driving the lifting frame 24 and the linkage 241 to rotate synchronously. The bent structure at the top of the linkage 241 slides on the screw rod 242. Under the limiting action of the screw rod 242, the lifting frame 24 moves upward, which allows the rotating scraper 25 to level the active ingredients that have been poured into the processing frame 1. As the thickness of the active ingredients at the bottom of the processing frame 1 increases, the scraper 25 moves upward adaptively through the cooperation of the screw rod 242, the lifting frame 24, and the linkage 241, so that the scraper 25 can always level the active ingredients. The active ingredients are evenly distributed at the bottom of the processing frame 1, ensuring the uniformity of the mixing of the active ingredients.

[0048] It should be noted that the raw materials poured into the processing frame 1 are always located below the mixing rack 22 and at a certain distance from the mixing rack 22. It is necessary to ensure that the amount of raw materials does not obstruct the normal circumferential rotation of the mixing rod 23 during the mixing process.

[0049] Furthermore, the bending structure can continuously scrape off the raw materials adhering to the screw rod 242 as it moves along the screw rod 242.

[0050] An extension frame 31 is mounted on the ring frame 3. A drive shaft 32 is rotatably mounted on the extension frame 31 via bearings. A gear 33 is mounted on the drive shaft 32. An annular rack plate 34 that meshes with the corresponding gear 33 is mounted on the processing frame 1. A lifting rod 42 is slidably disposed through the connecting plate 41 corresponding to any support frame 4. A linkage rod 43 is mounted on the top of the lifting rod 42. A lifting cylinder 44 is mounted on the connecting plate 41. The telescopic end of the lifting cylinder 44 is connected to the corresponding linkage rod 43.

[0051] The lifting rod 42 is equipped with a fixing plate 45 corresponding to the processing frame 1. The fixing plate 45 is equipped with an annular plate 46 coaxial with the corresponding processing frame 1. The inner side wall of the annular plate 46 is provided with an annular groove. The bottom of the discharge port 11 is provided with a sealing plate 47 for opening and closing. The sealing plate 47 is connected to the bottom of the corresponding processing frame 1 through a telescopic spring rod, and the sealing plate 47 is limited and slidably disposed inside the annular groove.

[0052] The top of the sealing plate 47 is set as a horizontally placed triangular prism structure, and multiple insertion rods 471 are evenly arranged thereon.

[0053] After the active ingredients are mixed, the lifting cylinder 44 is activated, causing the extension end of the lifting cylinder 44 to move the sealing plate 47 downward a certain distance, thus opening the discharge port 11. The mixed active ingredients inside the processing frame 1 fall from the discharge port 11. At this time, the existing drive motor drives the corresponding drive shaft 32 to rotate. During the rotation of the drive shaft 32, the gear 33 rotates. During the rotation of the gear 33, it meshes with the annular rack plate 34, causing the corresponding processing frame 1 to rotate synchronously. The active ingredients are evenly spread into the next processing frame 1. It should be noted that the rotation direction of the processing frame 1 is opposite to the rotation direction of the rotating shaft 21.

[0054] To prevent the active ingredient from clogging the outlet 11, the extension end of the lifting cylinder 44, through the cooperation of the lifting rod 42 and the linkage rod 43, drives the fixed plate 45 to swing up and down repeatedly. During the swinging up and down movement of the fixed plate 45, the sealing plate 47, which has moved down a certain distance, moves up and down repeatedly through the annular plate 46. During this process, the processing frame 1 can drive the sealing plate 47 to rotate circumferentially inside the annular groove through the telescopic spring rod. During the reciprocating movement of the sealing plate 47, the insertion rod 471 can loosen the active ingredient near the outlet 11, preventing the active ingredient from accumulating at the outlet 11 and being unable to fall. The inclined surface of the triangular prism structure prevents the active ingredient from accumulating on its surface, thus preventing the active ingredient from accumulating on the sealing plate 47.

[0055] The telescopic spring rod acts as a connection after the sealing plate 47 moves down a certain distance, which means that the sealing plate 47 is simultaneously rotated circumferentially under the action of the processing frame 1 during the up-and-down reciprocating movement.

[0056] See Figure 7The rotation of the rotating shaft 21 drives the stirring frame 22 and the linkage 241 to rotate synchronously. The bent structure of the linkage 241 moves on the screw rod 242, thereby driving the lifting frame 24 and the scraper 25 to move upward synchronously. When the bent structure moves to the extreme position at the top of the screw rod 242 with the transmission mechanism 5, the rotating shaft 21 continues to rotate. Since there is no limit constraint at the top of the screw rod 242 and the bent structure itself has gravitational potential energy, the bent structure will naturally slide down to point B of the screw rod 242 due to gravity the instant it passes point A at the top of the screw rod 242. After that, the bent structure will move back to point A along the upward trajectory of the screw rod 242 with the continuous rotation of the rotating shaft 21, and repeat the above sliding action after reaching point A.

[0057] When it is necessary to feed the active material inside the corresponding processing frame 1, the processing frame 1 can be driven by the screw rod 242 and the bending structure during rotation. At this time, the bending structure moves synchronously along the screw rod 242 and drives the lifting frame 24 to move down. During this process, the stirring rod 23 is also rotating relative to the processing frame 1. Thus, the processing frame 1 and the stirring rod 23 cooperate with each other to ensure that the active ingredients are always in a flowing state, ensuring that the active ingredients can flow out from the discharge port 11. As the active ingredients fall down from the discharge port 11, a concave area will appear where the active ingredients are located at the discharge port 11. In addition, during the downward movement of the lifting frame 24, the active ingredients can be scraped down to the concave area of ​​the discharge port, accelerating the falling of the active ingredients.

[0058] During the process of spreading the mixed active ingredients to the next processing frame 1, excipients are poured into the corresponding processing frame 1. During this process, the scraper 25, which moves upward and rotates circumferentially, can spread the excipients in the corresponding processing frame 1, while the active ingredients falling from above can be sprinkled on the excipients. Then, another layer of excipients is spread, and another layer of active ingredients is sprinkled on top. By repeating the above steps, the active ingredients can be evenly distributed in the excipients through the layered and alternating mixing process, and the active ingredients can be evenly adhered to the surface of the excipients by the sprinkling method.

[0059] At this point, a mixture of active ingredients and excipients is obtained. However, the concentration of active ingredients in this mixture is relatively high. By repeating the above steps, the active ingredients can be diluted until the desired concentration of active ingredients in the compound dibazol hydrochlorothiazide capsule raw material is obtained.

[0060] Finally, the raw material of compound dibazol hydrochlorothiazide capsules obtained by stirring and mixing falls from the outlet 11 of the corresponding processing box 1 and is collected through the existing collection box (not shown in the figure).

[0061] As the mixture continues to fall downwards, its volume gradually increases. To reduce the resistance of the mixture to the stirring rod 23 during stirring and to prevent the stirring rod 23 from getting stuck due to excessive resistance, the rotation speed of the stirring rod 23 is gradually reduced from top to bottom. Specifically, except for the bottommost rotating shaft 21, the remaining rotating shafts 21 all pass through the bottom of the corresponding processing frame 1. Another support frame 4 is provided with a transmission mechanism 5 between two adjacent processing frames 1, including a fixed frame 51 symmetrically arranged along the length of the support frame 4. A transmission shaft 52 is rotatably mounted between the fixed frames 51 through bearings. The transmission shaft 52 is connected to the rotating shaft 21 of the two adjacent processing frames 1 by belt drive.

[0062] The pulley above the circumference of the drive shaft 52 is designated as pulley one 521, the pulleys that are sleeved on the ends of all rotating shafts 21 facing each other are designated as pulley two 211, and the pulley sleeved on the bottom of the drive shaft 52 is designated as pulley three 522. The diameter of pulley one 521 is larger than the diameter of pulley two 211, and the diameter of pulley two 211 is equal to the diameter of pulley three 522.

[0063] In specific operation, during the rotation of the rotating shaft 21 corresponding to the upper processing frame 1, the corresponding transmission shaft 52 is driven to rotate through the interaction of pulley 1 521, pulley 211 and belt. Since the diameter of pulley 1 521 is larger than that of pulley 211, the speed of transmission shaft 52 is less than that of the rotating shaft 21 corresponding to the upper processing frame 1. During the rotation of transmission shaft 52, the rotating shaft 21 corresponding to the lower processing frame 1 is driven to rotate through the interaction of pulley 3 522 and belt. Thus, through the above steps, the speed of rotating shaft 21 distributed from top to bottom gradually decreases to adapt to the scenario where the mass of raw materials inside the processing frames 1 gradually increases from top to bottom. This avoids the risk of the stirring rod 23 getting stuck inside the raw materials due to the excessive speed of rotating shaft 21 as the mass of raw materials inside the processing frame 1 increases. It effectively avoids the risk of jamming and seizing when the stirring rod 23 is running under high load raw materials if the rotating shaft 21 still maintains a high speed after the mass of raw materials inside the lower processing frame 1 increases.

[0064] The working principle of this invention is as follows: When the device is working, the active ingredients are first poured into the uppermost processing frame 1. An external driving force drives the rotating shaft 21 to rotate. The rotating shaft 21 drives the stirring rod 23 to rotate axially through the stirring frame 22, thus mixing and stirring the active ingredients. At the same time, the rotating shaft 21 drives the lifting frame 24 and the linkage rod 241 to rotate synchronously. The bent structure of the linkage rod 241 slides on the spiral rod 242 on the inner wall of the processing frame 1. Under the limiting action of the spiral rod 242, the lifting frame 24 is driven to move upward. The scraper 25 at the bottom of the lifting frame 24 flattens the accumulated active ingredients. As the thickness of the active ingredients at the bottom of the processing frame 1 increases, the scraper 25 moves upward adaptively, always keeping the active ingredients evenly distributed, ensuring uniform mixing. The bent structure can also scrape off the raw materials attached to the spiral rod 242.

[0065] After the active ingredients are mixed, the lifting cylinder 44 is activated, which moves the sealing plate 47 down to open the discharge port 11. The mixed active ingredients in the processing frame 1 fall out. At this time, the drive motor drives the drive shaft 32 to rotate. The drive shaft 32 meshes with the annular rack plate 34 on the processing frame 1 through the gear 33, which drives the processing frame 1 to rotate, so that the active ingredients are evenly spread to the next processing frame 1. The rotation direction of the processing frame 1 is opposite to that of the rotating shaft 21. In order to avoid the discharge port 11 from being blocked, the lifting cylinder 44 drives the fixed plate 45 to swing up and down through the lifting rod 42 and the linkage rod 43, which in turn drives the sealing plate 47 to move back and forth. The insertion rod 471 on the sealing plate 47 loosens the raw materials near the discharge port 11, and the triangular prism structure on its top prevents the active ingredients from accumulating on the surface.

[0066] When the rotating shaft 21 drives the stirring frame 22 to rotate, it simultaneously drives the linkage rod 241 to rotate, causing the bent structure to move along the spiral rod 242 and drive the lifting frame 24 to move upward. When the bent structure moves to point A at the top of the spiral rod 242, it will naturally slide down to point B of the spiral rod 242 due to gravity. Then, as the rotating shaft 21 continues to rotate, the bent structure moves back to point A along the upward trajectory of the spiral rod 242. After reaching point A, it repeats the sliding action, realizing the reciprocating lifting and leveling operation of the lifting frame 24 and the scraper 25. During material discharge, the rotation of the processing frame 1 can drive the lifting frame 24 to move downward through the cooperation of the spiral rod 242 and the bent structure. The continuous rotation of the stirring rod 23 keeps the active ingredients flowing. The downward movement of the lifting frame 24 can also scrape the active ingredients towards the recessed area of ​​the discharge port 11, accelerating the falling.

[0067] To adapt to the scenario where the raw material mass gradually increases within the processing frame 1 from top to bottom, the device uses a transmission mechanism 5 to gradually reduce the rotational speed of the rotating shaft 21. The rotating shaft 21 of the previous processing frame 1 drives the transmission shaft 52 to rotate via pulley 1 521, pulley 211, and a belt. Because the diameter of pulley 1 521 is larger than that of pulley 211, the rotational speed of the transmission shaft 52 is lower than that of the previous rotating shaft 21. The transmission shaft 52 then drives the rotating shaft 21 of the next processing frame 1 to rotate via pulley 3 522 and a belt, and so on, so that the rotational speed of the rotating shaft 21 gradually decreases from top to bottom. This reduces the resistance of the mixture to the stirring rod 23 during the stirring process, avoids malfunctions such as jamming or seizing of the stirring rod 23 due to the increased raw material mass in the lower processing frame 1 and the excessively high rotational speed of the rotating shaft 21, and ensures continuous stirring and stable operation of the device.

[0068] In the description of this invention, the terms "first," "second," "another," and "yet another" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, features defined as "first" or "second" may explicitly or implicitly include one or more features. In the description of embodiments of this invention, "a plurality of" means two or more, unless otherwise explicitly specified.

[0069] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "connected" and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances. Furthermore, in the description of this invention, unless otherwise stated, "a plurality of" means two or more.

[0070] Although embodiments of the invention have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.

Claims

1. A mixing and stirring apparatus for pretreatment of raw materials for compound dibazol hydrochlorothiazide capsules, characterized in that: It includes multiple processing frames (1) evenly distributed from top to bottom with upward openings. The processing frame (1) has a discharge port (11) at the bottom and a stirring mechanism (2) installed inside the processing frame (1). It also includes multiple ring frames (3) that cooperate one-to-one with the processing frame (1), and the processing frame (1) is rotatably installed inside the ring frame (3); Support frames (4) are arranged radially symmetrically along the processing frame (1), and the ring frame (3) is installed on the support frame (4) on the corresponding side through the connecting plate (41); The stirring mechanism (2) includes a rotating shaft (21) that is rotatably mounted in the middle of the bottom of the processing frame (1) via a bearing. A stirring frame (22) is mounted on the rotating shaft (21). Multiple stirring rods (23) are evenly mounted on the bottom of the stirring frame (22) along its length. A lifting frame (24) that can move up and down is slidably mounted on the rotating shaft (21). The stirring rod (23) passes through the lifting frame (24). A scraper (25) is installed at the bottom of the lifting frame (24) and between two adjacent stirring rods (23). The top of the lifting frame (24) is equipped with a linkage rod (241), the top of the linkage rod (241) passes through the corresponding stirring frame (22) and is provided with a bending structure. The inner wall of the processing frame (1) is provided with a continuous spiral rod (242), and the bending structure is attached to the spiral rod (242).

2. The compound dibazol hydrochlorothiazide capsule raw material pretreatment stirring and mixing device according to claim 1, characterized in that: An extension frame (31) is installed on the ring frame (3), and a drive shaft (32) is rotatably installed on the extension frame (31) via a bearing. A gear (33) is installed on the drive shaft (32). The processing frame (1) is equipped with an annular rack plate (34) that meshes with the corresponding gear (33). The drive shaft (32) can drive the processing frame (1) to rotate through the meshing of the gear (33) and the annular rack plate (34), and the rotation direction of the processing frame (1) is opposite to the rotation direction of the rotating shaft (21).

3. The compound dibazol hydrochlorothiazide capsule raw material pretreatment stirring and mixing device according to claim 1, characterized in that: Each of the support frames (4) has a connecting plate (41) with a lifting rod (42) slidably mounted on it. A linkage rod (43) is installed on the top of the lifting rod (42). A lifting cylinder (44) is installed on the connecting plate (41). The extension end of the lifting cylinder (44) is connected to the corresponding linkage rod (43). The lifting rod (42) is equipped with a fixing plate (45) that corresponds one-to-one with the processing frame (1). The fixing plate (45) is equipped with an annular plate (46) that is coaxial with the corresponding processing frame (1). The inner side wall of the annular plate (46) is provided with an annular groove.

4. The compound dibazol hydrochlorothiazide capsule raw material pretreatment stirring and mixing device according to claim 3, characterized in that: The bottom of the discharge port (11) is provided with a sealing plate (47) for opening and closing. The sealing plate (47) is connected to the bottom of the corresponding processing frame (1) by a telescopic spring rod, and the sealing plate (47) is limited and slidably disposed inside the annular groove. The lifting cylinder (44) can drive the sealing plate (47) to move up and down to open and close the discharge port (11).

5. The compound dibazol hydrochlorothiazide capsule raw material pretreatment stirring and mixing device according to claim 4, characterized in that: The top of the sealing plate (47) is set as a horizontally placed triangular prism structure, and multiple insertion rods (471) are evenly arranged thereon; The lifting cylinder (44) can drive the connecting plate (41) to move up and down repeatedly through the lifting rod (42) and the linkage rod (43), thereby driving the sealing plate (47) to move up and down repeatedly. The insertion rod (471) can loosen the raw material near the discharge port (11).

6. The compound dibazol hydrochlorothiazide capsule raw material pretreatment stirring and mixing device according to claim 1, characterized in that: The bent structure can slide along the screw rod (242) when it rotates with the rotating shaft (21), and under the limiting action of the screw rod (242), it drives the lifting frame (24) to move upward synchronously; When the bent structure moves to the extreme position at the top of the screw rod (242), it can slide naturally down the guide slope of the screw rod (242) to the second to last section of the screw rod (242), and continue to rotate with the rotating shaft (21) to repeat the lifting and lowering action.

7. The compound dibazol hydrochlorothiazide capsule raw material pretreatment stirring and mixing device according to claim 1, characterized in that: Another support frame (4) is provided with a transmission mechanism (5) between two adjacent processing frames (1). The transmission mechanism (5) includes fixed frames (51) symmetrically arranged along the length of the support frame (4). A transmission shaft (52) is rotatably mounted between the fixed frames (51) via bearings. The transmission shaft (52) is connected to the corresponding rotating shaft (21) of the two adjacent processing frames (1) via belt drive.

8. The compound dibazol hydrochlorothiazide capsule raw material pretreatment stirring and mixing device according to claim 7, characterized in that: The pulley above the circumference of the drive shaft (52) is designated as pulley one (521), the pulleys that are connected to the ends of all rotating shafts (21) facing each other are designated as pulley two (211), and the pulley connected to the bottom of the drive shaft (52) is designated as pulley three (522). The diameter of pulley one (521) is larger than the diameter of pulley two (211), and the diameter of pulley two (211) is equal to the diameter of pulley three (522), which can make the rotation speed of the rotating shafts (21) distributed from top to bottom gradually decrease.

9. The compound dibazol hydrochlorothiazide capsule raw material pretreatment stirring and mixing device according to claim 1, characterized in that: The processing frame (1) rotates during material feeding and drives the lifting frame (24) to move down through the cooperation of the spiral rod (242) and the bending structure. The stirring rod (23) remains in a rotating state relative to the processing frame (1). The downward movement of the lifting frame (24) can scrape the raw material towards the recessed area of ​​the discharge port (11).

10. The compound dibazol hydrochlorothiazide capsule raw material pretreatment stirring and mixing device according to claim 1, characterized in that: The bending structure scrapes off the raw material adhering to the screw rod (242) during its movement on the screw rod (242); The raw material poured into the processing frame (1) is always located below the mixing rack (22) and kept at a distance from the mixing rack (22) to avoid obstructing the normal circumferential rotation of the mixing rod (23).

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