Traditional Chinese medicine cigarette holder for treating pulmonary nodule and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine cigarette holder for treating pulmonary nodules and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine instruments.The traditional Chinese medicine cigarette holder comprises a cigarette holder body, a filter layer, a heating unit and a traditional Chinese medicine containing cavity are sequentially arranged in the cigarette holder body from right to left, the filter layer is connected with the heating unit, and the heating unit is connected with the traditional Chinese medicine containing cavity; a traditional Chinese medicine composition is arranged in the traditional Chinese medicine containing cavity, the heating unit atomizes the traditional Chinese medicine composition through heating power, and a connector is arranged at one end of the cigarette holder body. According to the traditional Chinese medicine cigarette holder for treating pulmonary nodules and the preparation method of the traditional Chinese medicine cigarette holder, the traditional Chinese medicine atomization technology and the cigarette holder structure are fused, and the'suction-treatment 'integrated design is achieved; the composition is screened by modern pharmacology, is precisely compatible aiming at the pulmonary nodule pathological mechanism, and has the support of traditional Chinese medicine theory and the verification of modern science.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine medical device technology, and in particular to a traditional Chinese medicine cigarette holder for treating pulmonary nodules and its preparation method. Background Technology

[0002] Oral administration of traditional Chinese medicine is a traditional method of administration. After the drug is absorbed through the gastrointestinal tract, it needs to pass through the first-pass effect of the liver. For Chinese medicine components that target the lungs, this method of administration has problems such as low delivery efficiency of effective components, poor lung targeting, and large loss of effective components.

[0003] Cigarette mouthpieces are widely used smoking aids in daily life. Most existing cigarette mouthpieces only have the single function of filtering harmful substances such as tar and nicotine in cigarette smoke. They do not integrate the functions of constant temperature atomization and directional delivery of traditional Chinese medicine ingredients. Therefore, they cannot achieve the integrated application of cigarette smoke filtration and lung delivery of traditional Chinese medicine ingredients, and have the defects of single function and limited application scenarios. Summary of the Invention

[0004] The purpose of this invention is to provide a traditional Chinese medicine cigarette holder for treating pulmonary nodules and its preparation method. It integrates traditional Chinese medicine atomization technology with the cigarette holder structure to achieve an integrated "inhalation-treatment" design. By setting a temperature control component, it ensures that the traditional Chinese medicine is atomized within the optimal temperature range, avoiding high temperature damage to the effective components. The formula is screened by modern pharmacology and is precisely matched to the pathological mechanism of pulmonary nodules, combining the support of traditional Chinese medicine theory with modern scientific verification.

[0005] To achieve the above objectives, the present invention provides a traditional Chinese medicine cigarette holder for treating pulmonary nodules, comprising a cigarette holder body, wherein a filter layer, a heating unit and a traditional Chinese medicine containing cavity are arranged sequentially from right to left inside the cigarette holder body, the filter layer is connected to the heating unit and the heating unit is connected to the traditional Chinese medicine containing cavity, a traditional Chinese medicine composition is disposed inside the traditional Chinese medicine containing cavity, the heating unit atomizes the traditional Chinese medicine composition by heat, and an interface is provided at one end of the cigarette holder body.

[0006] Preferably, the traditional Chinese medicine composition includes Prunella vulgaris, Uncaria rhynchophylla, Fritillaria thunbergii, Ostrea gigas, Scrophularia ningpoensis, Salvia miltiorrhiza, and Panax notoginseng, in a mass ratio of 3:2:2:2:1:1:1.

[0007] Preferably, the traditional Chinese medicine composition is ultra-finely pulverized, and the traditional Chinese medicine composition is treated with cyclodextrin inclusion technology.

[0008] Preferably, the heating unit is equipped with a temperature control component, the temperature control component has a temperature control range of 80-120℃, and the control accuracy of the temperature control component is ±2℃.

[0009] Preferably, the heating unit uses a flexible thin-film heating element with a rated power of 2-5W.

[0010] Preferably, the herbal medicine container has a two-layer structure, with the upper layer being a herbal medicine powder container and the lower layer being an atomizer, and the herbal medicine composition is placed inside the herbal medicine powder container.

[0011] Preferably, the filter layer is an activated carbon filter layer, and the activated carbon filter layer is replaceable.

[0012] Preferably, the mouthpiece body is made of medical-grade silicone and high-temperature resistant ceramic composite material.

[0013] A method for preparing a traditional Chinese medicine cigarette holder for treating pulmonary nodules includes the following steps: S1: Mix the ingredients in a mass ratio of 3:2:2:2:1:1:1 and accurately weigh out 300g of Prunella vulgaris, 200g of Uncaria rhynchophylla, 200g of Fritillaria thunbergii, 200g of Ostrea gigas, 100g of Scrophularia ningpoensis, 100g of Salvia miltiorrhiza, and 100g of Panax notoginseng. S2: Process the raw materials in S1 according to the specifications of the Chinese Pharmacopoeia, remove impurities, and then dry them at low temperature under vacuum until the moisture content is ≤8%; S3: The dried raw materials are put into an ultra-micro pulverizer for pulverization. After pulverization, they are passed through a 300-mesh standard sieve to obtain ultra-micro powder of traditional Chinese medicine. S4: Mix the ultrafine powder of traditional Chinese medicine with β-cyclodextrin at a mass ratio of 1:5, add 60% ethanol aqueous solution, stir and encapsulate in a constant temperature water bath at 50℃ for 1.5h, refrigerate and stand for 24h, then filter, and vacuum dry the filter cake at 45℃ until the moisture content is ≤6% to obtain the encapsulated powder, which is sealed and protected from light for later use. S5: The mouthpiece body is made of medical-grade silicone and high-temperature resistant ceramic composite material through 3D printing. The mouthpiece body is reserved with filter layer installation position, Chinese medicine cavity installation position, heating unit installation position and interface. The formed mouthpiece body is deburred and sterilized for later use. S6: A flexible thin-film heating element with a rated power of 3W is selected as the heating unit, and a temperature control component is used for calibration. After calibration, the temperature control range is stable at 80-120℃, and the temperature control accuracy is ±2℃. S7: The calibrated heating unit is attached to the outer wall of the upper and lower layered Chinese medicine containing cavity. The upper layer of the Chinese medicine containing cavity is the Chinese medicine powder chamber, and the lower layer is the atomizer. A breathable isolation layer is set between the two. S8: Fill the inclusion powder prepared by S1-S4 into the Chinese medicine powder hopper, seal it, and then assemble it into the corresponding mounting position of the mouthpiece body; S9: Install a replaceable activated carbon filter layer at the inhalation end of the mouthpiece body, assemble the interface at the end, and after the overall assembly is completed, conduct air tightness testing, temperature control performance testing, and atomization performance testing. After all indicators are qualified, the finished Chinese medicine atomizing mouthpiece is obtained.

[0014] Therefore, this invention adopts the above-mentioned Chinese medicine cigarette holder for treating pulmonary nodules and its preparation method, integrating Chinese medicine atomization technology with the cigarette holder structure to achieve an integrated "inhalation-treatment" design; by setting a temperature control component, it ensures that the Chinese medicine is atomized in the optimal temperature range, avoiding high temperature damage to the effective components; the formula is screened by modern pharmacology and is precisely matched to the pathological mechanism of pulmonary nodules, combining the support of traditional Chinese medicine theory with modern scientific verification.

[0015] The technical solution of the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall structure of the traditional Chinese medicine cigarette holder for treating pulmonary nodules in this invention. Figure 2 This is an electron microscope image of the ultrafine powder of the traditional Chinese medicine composition in this invention.

[0017] Figure Labels 1. Medicine container; 2. Heating unit; 3. Filter layer. Detailed Implementation

[0018] The technical solution of the present invention will be further described below with reference to the accompanying drawings and embodiments.

[0019] Unless otherwise defined, the technical or scientific terms used in this invention shall have the ordinary meaning understood by one of ordinary skill in the art to which this invention pertains. The terms "first," "second," and similar terms used in this invention do not indicate any order, quantity, or importance, but are merely used to distinguish different components. Terms such as "comprising" or "including" mean that the element or object preceding the word encompasses the elements or objects listed following the word and their equivalents, without excluding other elements or objects. Terms such as "connected" or "linked" are not limited to physical or mechanical connections, but can include electrical connections, whether direct or indirect. Terms such as "upper," "lower," "left," and "right" are used only to indicate relative positional relationships; when the absolute position of the described object changes, the relative positional relationship may also change accordingly.

[0020] like Figure 1As shown, a traditional Chinese medicine cigarette holder for treating pulmonary nodules includes a cigarette holder body. The cigarette holder body is made of medical-grade silicone and high-temperature resistant ceramic composite material, and is integrally formed by 3D printing. The inside of the cigarette holder body has reserved mounting positions for a filter layer 3, a heating unit 2, and a traditional Chinese medicine containing cavity 1. The filter layer 3, the heating unit 2, and the traditional Chinese medicine containing cavity 1 are installed sequentially from right to left inside the cigarette holder body. One end of the filter layer 3 is connected to the heating unit 2, and the end of the heating unit 2 away from the filter layer 3 is thermally coupled to the traditional Chinese medicine containing cavity 1. The traditional Chinese medicine containing cavity 1 is filled with a traditional Chinese medicine composition for treating pulmonary nodules. The heating unit 2 atomizes the traditional Chinese medicine composition through heat. Under the action of constant temperature heat, the traditional Chinese medicine composition is atomized to form 0.5-5μm medicinal mist particles, which enter the respiratory tract through the breathing airflow. An interface is installed at the end of the cigarette holder body near the filter layer 3.

[0021] like Figure 2 As shown, the traditional Chinese medicine composition includes Prunella vulgaris, Uncaria rhynchophylla, Fritillaria thunbergii, Ostrea gigas, Scrophularia ningpoensis, Salvia miltiorrhiza, and Panax notoginseng, in a mass ratio of 3:2:2:2:1:1:1, that is, accurately weigh 300g of Prunella vulgaris, 200g of Uncaria rhynchophylla, 200g of Fritillaria thunbergii, 200g of Ostrea gigas, 100g of Scrophularia ningpoensis, 100g of Salvia miltiorrhiza, and 100g of Panax notoginseng; process the above raw materials according to the specifications of the Chinese Pharmacopoeia, remove impurities, and then dry at low temperature under vacuum until the moisture content is ≤8%; the dried... The raw materials were then fed into an ultra-fine pulverizer for pulverization. After pulverization, the powder was passed through a 300-mesh standard sieve to obtain ultra-fine powder of traditional Chinese medicine. The particle size D90 was tested to be ≤45μm. The ultra-fine powder of traditional Chinese medicine was mixed with β-cyclodextrin at a mass ratio of 1:5, and 60% ethanol aqueous solution was added. The mixture was stirred and encapsulated in a constant temperature water bath at 50℃ for 1.5h. After being refrigerated and allowed to stand for 24h, the mixture was filtered. The filter cake was vacuum dried at 45℃ until the moisture content was ≤6% to obtain encapsulated powder, which was then sealed and stored in the dark for later use.

[0022] The heating unit 2 is equipped with a temperature control component. The temperature control component has a temperature control range of 80-120℃ and a control accuracy of ±2℃. The preferred temperature control component is a temperature sensor. The heating unit 2 uses a flexible thin film heating element, and the power of the flexible thin film heating element is controlled between 2-5W.

[0023] The Chinese medicine container 1 has a two-layer structure. The upper layer is a Chinese medicine powder chamber, in which the Chinese medicine composition is filled. The lower layer is an atomizer, which is used to achieve uniform atomization of the Chinese medicine composition at a set temperature through heat conduction.

[0024] The preferred filter layer 3 is a replaceable activated carbon filter layer, which is installed inside the mouthpiece body at the air intake end.

[0025] A method for preparing a traditional Chinese medicine cigarette holder for treating pulmonary nodules includes the following steps: S1: Mix the ingredients in a mass ratio of 3:2:2:2:1:1:1 and accurately weigh out 300g of Prunella vulgaris, 200g of Uncaria rhynchophylla, 200g of Fritillaria thunbergii, 200g of Ostrea gigas, 100g of Scrophularia ningpoensis, 100g of Salvia miltiorrhiza, and 100g of Panax notoginseng. S2: Process the above raw materials according to the specifications of the Chinese Pharmacopoeia, remove impurities, and then dry them at low temperature under vacuum until the moisture content is ≤8%; S3: The dried raw materials are put into an ultra-micro pulverizer for pulverization. After pulverization, they are passed through a 300-mesh standard sieve to obtain ultra-micro powder of traditional Chinese medicine. S4: Mix the ultrafine powder of traditional Chinese medicine with β-cyclodextrin at a mass ratio of 1:5, add 60% ethanol aqueous solution, stir and encapsulate in a constant temperature water bath at 50℃ for 1.5h, refrigerate and stand for 24h, then filter, and vacuum dry the filter cake at 45℃ until the moisture content is ≤6% to obtain the encapsulated powder, which is sealed and protected from light for later use. S5: The mouthpiece body is made of medical-grade silicone and high-temperature resistant ceramic composite material through 3D printing. The mouthpiece body is reserved with 3 mounting positions for filter layer, 1 mounting position for Chinese medicine cavity, 2 mounting position for heating unit and interface. The formed mouthpiece body is deburred and sterilized for later use. S6: A flexible thin-film heating element with a rated power of 3W is selected as heating unit 2, and a temperature control component is used for calibration. After calibration, the temperature control range is stable at 80-120℃, and the temperature control accuracy is ±2℃. S7: The calibrated heating unit 2 is attached to the outer wall of the upper and lower layered Chinese medicine container 1. The upper layer of the Chinese medicine container 1 is the Chinese medicine powder chamber, and the lower layer is the atomizer. A breathable isolation layer is set between the two. S8: Fill the inclusion powder prepared by S1-S4 into the Chinese medicine powder hopper, seal it, and then assemble it into the corresponding mounting position of the mouthpiece body; S9: Install a replaceable activated carbon filter layer at the inhalation end of the mouthpiece body, assemble the interface at the end, and after the overall assembly is completed, conduct air tightness testing, temperature control performance testing, and atomization performance testing. After all indicators are qualified, the finished Chinese medicine atomizing mouthpiece is obtained.

[0026] This invention provides a traditional Chinese medicine cigarette holder for treating pulmonary nodules and its preparation method. It integrates traditional Chinese medicine atomization technology with the cigarette holder structure to achieve an integrated "inhalation-treatment" design. By setting a temperature control component, it ensures that the traditional Chinese medicine is atomized within the optimal temperature range, avoiding high temperature damage to the effective components. The formula is screened by modern pharmacology and is precisely matched to the pathological mechanism of pulmonary nodules, combining the support of traditional Chinese medicine theory with modern scientific verification.

[0027] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can still be made to the technical solutions of the present invention, and these modifications or equivalent substitutions cannot cause the modified technical solutions to deviate from the spirit and scope of the technical solutions of the present invention.

Claims

1. A traditional Chinese medicine cigarette holder for treating pulmonary nodules, characterized in that: The device includes a mouthpiece body, inside which, from right to left, are arranged a filter layer, a heating unit, and a traditional Chinese medicine containing cavity. The filter layer is connected to the heating unit, and the heating unit is connected to the traditional Chinese medicine containing cavity. The traditional Chinese medicine containing cavity contains a traditional Chinese medicine composition. The heating unit atomizes the traditional Chinese medicine composition by heat. One end of the mouthpiece body is provided with an interface.

2. The traditional Chinese medicine cigarette holder for treating pulmonary nodules according to claim 1, characterized in that: The traditional Chinese medicine composition includes Prunella vulgaris, Uncaria rhynchophylla, Fritillaria thunbergii, Ostrea gigas, Scrophularia ningpoensis, Salvia miltiorrhiza, and Panax notoginseng, in a mass ratio of 3:2:2:2:1:1:

1.

3. The traditional Chinese medicine cigarette holder for treating pulmonary nodules according to claim 2, characterized in that: The traditional Chinese medicine composition is subjected to ultra-fine pulverization and is treated with cyclodextrin inclusion technology.

4. The traditional Chinese medicine cigarette holder for treating pulmonary nodules according to claim 1, characterized in that: The heating unit is equipped with a temperature control component, the temperature control range of which is 80-120℃, and the control accuracy of which is ±2℃.

5. A traditional Chinese medicine cigarette holder for treating pulmonary nodules according to claim 4, characterized in that: The heating unit uses a flexible thin-film heating element with a rated power of 2-5W.

6. The traditional Chinese medicine cigarette holder for treating pulmonary nodules according to claim 1, characterized in that: The herbal medicine container has a two-layer structure, with the upper layer being a herbal medicine powder container and the lower layer being an atomizer. The herbal medicine composition is disposed inside the herbal medicine powder container.

7. A traditional Chinese medicine cigarette holder for treating pulmonary nodules according to claim 1, characterized in that: The filter layer is an activated carbon filter layer, and the activated carbon filter layer is replaceable.

8. A traditional Chinese medicine cigarette holder for treating pulmonary nodules according to claim 1, characterized in that: The mouthpiece body is made of medical-grade silicone and high-temperature resistant ceramic composite material.

9. A method for preparing a traditional Chinese medicine cigarette holder for treating pulmonary nodules, based on the traditional Chinese medicine cigarette holder according to any one of claims 1-8, characterized in that, Includes the following steps: S1: Mix the ingredients in a mass ratio of 3:2:2:2:1:1:1 and accurately weigh out 300g of Prunella vulgaris, 200g of Uncaria rhynchophylla, 200g of Fritillaria thunbergii, 200g of Ostrea gigas, 100g of Scrophularia ningpoensis, 100g of Salvia miltiorrhiza, and 100g of Panax notoginseng. S2: Process the raw materials in S1 according to the specifications of the Chinese Pharmacopoeia, remove impurities, and then dry them at low temperature under vacuum until the moisture content is ≤8%; S3: The dried raw materials are put into an ultra-micro pulverizer for pulverization. After pulverization, they are passed through a 300-mesh standard sieve to obtain ultra-micro powder of traditional Chinese medicine. S4: Mix the ultrafine powder of traditional Chinese medicine with β-cyclodextrin at a mass ratio of 1:5, add 60% ethanol aqueous solution, stir and encapsulate in a constant temperature water bath at 50℃ for 1.5h, refrigerate and stand for 24h, then filter, and vacuum dry the filter cake at 45℃ until the moisture content is ≤6% to obtain the encapsulated powder, which is sealed and protected from light for later use. S5: The mouthpiece body is made of medical-grade silicone and high-temperature resistant ceramic composite material through 3D printing. The mouthpiece body is reserved with filter layer installation position, Chinese medicine cavity installation position, heating unit installation position and interface. The formed mouthpiece body is deburred and sterilized for later use. S6: A flexible thin-film heating element with a rated power of 3W is selected as the heating unit, and a temperature control component is used for calibration. After calibration, the temperature control range is stable at 80-120℃, and the temperature control accuracy is ±2℃. S7: The calibrated heating unit is attached to the outer wall of the upper and lower layered Chinese medicine containing cavity. The upper layer of the Chinese medicine containing cavity is the Chinese medicine powder chamber, and the lower layer is the atomizer. A breathable isolation layer is set between the two. S8: Fill the inclusion powder prepared by S1-S4 into the Chinese medicine powder hopper, seal it, and then assemble it into the corresponding mounting position of the mouthpiece body; S9: Install a replaceable activated carbon filter layer at the inhalation end of the mouthpiece body, assemble the interface at the end, and after the overall assembly is completed, conduct air tightness testing, temperature control performance testing, and atomization performance testing. After all indicators are qualified, the finished Chinese medicine atomizing mouthpiece is obtained.

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