Striking device of spinal cord injury animal model and operation method

Abstract

The invention provides a beating device for a spinal cord injury animal model, and belongs to the technical field of medical science. A one-way mechanism is additionally arranged on a firing pin positioner connected with a firing pin, and an automatic restorer is arranged on the firing pin; during use, the first positioning assembly in the firing pin positioner is connected with a firing pin, after the firing pin falls down to strike an experimental animal, the automatic restorer drives the firing pin to move upwards, meanwhile, the first positioning assembly connected with the firing pin bears upward force, the first positioning assembly rotates upwards along with the one-way mechanism, and then the one-way mechanism locks the first positioning assembly; the positioning assembly I is prevented from falling secondarily, so that the striker is prevented from striking the spinal cord of the experimental animal secondarily.

Description

Technical Field

[0001] This invention belongs to the field of medical technology, specifically relating to a striking device and operating method for an animal model of spinal cord injury. Background Technology

[0002] Spinal cord injury is caused by vertebral displacement or bone fragments protruding into the spinal canal after a vertebral fracture, resulting in varying degrees of damage to the spinal cord or spinal nerves. It commonly occurs in the middle and lower cervical vertebrae and the thoracolumbar junction, often presenting with sensory and motor dysfunction. In severe cases, quadriplegia may occur. Treatment options include medication, surgery, and rehabilitation. Animal models are frequently used to study spinal cord injury. However, in commonly used animal models of spinal cord injury, the impact of a falling heavy object with acceleration onto the relatively elastic spinal cord can easily cause secondary impacts and accidental blows.

[0003] Patent CN107837124A discloses a striking device for an animal model of spinal cord injury and its operating method, including: a base, an XY slide, a first handle, a second handle, a striking rod, a guide hole, a first striking rod clamping device, a second striking rod clamping device, a magnetostrictive displacement sensor, a suspension block, a lead screw slide, a connecting rod, an arc-shaped support, and a control box. In use, after the experimental subject is positioned directly below the striking rod, the control box first controls the lead screw slide to raise the striking rod to a set height; the control box then controls the first striking rod clamping device to release the striking rod, allowing it to fall freely; finally, after the striking rod falls, the control box controls the second striking rod clamping device to hold the rebounding striking rod. The magnetostrictive displacement sensor measures the falling trajectory of the striking rod in real time, and based on the falling trajectory, the control box controls the striking rod clamping device to hold the striking rod before the second strike.

[0004] However, the aforementioned technical solution includes a suspension block at the upper end of the striking rod to acquire its movement trajectory. However, this suspension block increases the weight of the striking rod, leading to inaccurate results when striking the test subject. Furthermore, the aforementioned technical solution involves controlling a second striking rod clamping device to hold the rebounding striking rod after the control box obtains the displacement information of the suspension block. This structure is complex and cumbersome to operate. If the information feedback from the suspension block is not timely enough, it will affect the striking rod's ability to withstand secondary impacts.

[0005] In the above technical solution, if the secondary impact trajectory of the striking rod is small, the sensor cannot accurately measure whether the animal model will be hit a second time, which will cause errors in judging whether the striking rod will hit a second time, and cannot accurately prevent the animal model from being hit a second time. Summary of the Invention

[0006] The purpose of this invention is to overcome the problem that existing impact devices for spinal cord injury animal models cannot accurately prevent experimental animals from being hit a second time. This invention provides an impact device for spinal cord injury animal models by adding a one-way mechanism to the impact pin positioner connected to the impact pin, and by setting an automatic reset device on the impact pin. In use, the positioning component 1 in the impact pin positioner is connected to the impact pin. After the impact pin falls and hits the experimental animal, the automatic reset device drives the impact pin to move upward. The positioning component 1, connected to the impact pin, is also subjected to an upward force. The positioning component 1 rotates upward with the one-way mechanism, which then locks the positioning component 1, preventing it from falling a second time and thus preventing the impact pin connected to the positioning component 1 from hitting the spinal cord of the experimental animal a second time.

[0007] Based on the above technical concept, the technical solution adopted by this invention is as follows: A striking device for an animal model of spinal cord injury includes: a striking pin and an animal model fixation platform; and further includes: The firing pin positioner includes a support frame, and positioning component one and positioning component two are disposed on the support frame. The first positioning component is located at the upper end of the firing pin and is used to control the free fall of the firing pin; The second positioning component is located at the lower end of the firing pin and is vertically positioned above the animal model fixing platform to adjust the direction in which the firing pin strikes the spinal cord of the experimental animal. An automatic reset device is located at the lower end of the firing pin and connected to the second positioning component. It is used to drive the firing pin to move upward after the firing pin falls and strikes the animal's spinal cord. A one-way mechanism is disposed between the positioning component one and the support frame, and is used to fix the positioning component one when the firing pin drives the positioning component one to move upward.

[0008] In the above technical solution, as a preferred embodiment, the one-way mechanism includes: a one-way rotating rod and a one-way locking component; One end of the unidirectional rotating rod is connected to the positioning component, and the other end is connected to the support frame through the unidirectional clamp.

[0009] Furthermore, the firing pin in the above technical solution further includes: a firing pin body, a rotating connector, and a connecting rod; One end of the connecting rod is connected to the positioning component, and the other end is connected to the firing pin body through the rotating connector.

[0010] Further specifying the above technical solution, the second positioning component includes a double-layer cross slide bar, a transmission belt, and a lower limit block: One end of the double-layer cross slide bar is connected to the lower limit block, and the other end is connected to the support frame; The transmission belt is mounted on the double-layer cross slide bar and is used to adjust the position of the lower limit block.

[0011] Furthermore, the double-layer cross slide bar in the above technical solution includes a movable rod, a control rod, and two drive units; the movable rod and the control rod are perpendicular to each other and arranged vertically via sliders; The movable rod is connected to the lower limit block; The two drive components are respectively located at both ends of the control lever and connected to the transmission belt. The position of the lower limit block is adjusted by controlling the transmission direction of the transmission belt.

[0012] Further specifying the above technical solution, the positioning component includes a square slide rail, and a transverse sliding rod and a longitudinal sliding rod disposed within the square slide rail; the transverse sliding rod and the longitudinal sliding rod are connected by an upper limit block; The upper end of the firing pin is positioned within the upper limit block.

[0013] To further define the above technical solution, the lower side of the animal model fixing platform is also provided with an animal model limb fixing mechanism; The animal model limb fixation mechanism includes straps, blocks, and an automatic tightening component; The strap is connected to the automatic tightening component; One end of the automatic tightening component is connected to the stop block, and the other end is fixedly installed at the lower end of the animal model fixing platform.

[0014] A further limitation on the above technical solution includes an automatic release mechanism, comprising: a spring and a release lever; The release lever is located on the side of the animal model fixing platform near the support frame; The spring is disposed on the bottom surface of the animal model fixing platform and is arranged along the same center line as the spring.

[0015] A further limitation on the above technical solution also includes a release lever; The release rod is located on one side of the support frame and is fixedly connected to the firing pin.

[0016] A method for operating a striking device in an animal model of spinal cord injury. Step 1: Secure the limbs of the experimental animal to the animal model mounting platform using straps; Step 2: Push the animal model fixing stage under the firing pin. After the stop block touches the side wall of the animal model fixing stage, it will squeeze the automatic tightening component. The automatic tightening component will further tighten the straps and fix the experimental animal. Step 3: Set the rotation direction and number of rotations of the drive units at both ends of the control lever to locate the position of the impact pin on the spinal cord of the experimental animal; Step 4: Release positioning component one, and the firing pin connected to positioning component one will fall freely to strike the spinal cord of the experimental animal; Step 5: After the firing pin strikes the spinal cord of the experimental animal once, the automatic reset device moves the firing pin and the positioning component connected to the firing pin upwards. Step Six: The unidirectional rotating rod connected to the positioning component one rotates after being subjected to an upward force. The unidirectional rotating rod and the unidirectional locking piece are locked together, and the positioning component one and the firing pin connected to the positioning component one are fixed to prevent the secondary firing pin from falling and hitting the spinal cord of the experimental animal. At this point, the animal model is successfully established.

[0017] The beneficial effects of this invention are: The present invention fixes the upper end of the firing pin by setting a positioning component one, and the lower end of the firing pin passes through the lower limit block in the positioning component two and is located above the position to strike the spinal cord of the experimental animal. In use, the locking nut set on the positioning component one can be unscrewed to allow the firing pin to fall freely and strike the spinal cord of the experimental animal.

[0018] The positioning component 2 provided by the present invention can adjust and position the location of the impact pin striking the spinal cord of the experimental animal by adjusting the position of the lower limit block.

[0019] The positioning component provided by the present invention includes an upper limit block; the upper limit block fixes the upper end of the firing pin, and the position of the upper limit block can be adjusted as the position of the lower limit block is adjusted, so that the firing pin always remains in a vertical state.

[0020] The present invention provides an automatic reset device on the firing pin. After the firing pin strikes, the automatic reset device drives the firing pin to move upward, and the positioning component connected to the firing pin is also subjected to an upward force. In this way, after the positioning component is subjected to the upward force, it rotates upward with the one-way locking member as the center. During the rotation of the one-way rotating member, the limiting ball in the one-way rotating member is locked into the sliding groove of the one-way locking member, and the one-way rotating member is locked by the one-way locking member. In turn, the positioning component connected to the one-way rotating member is locked, thereby preventing the positioning component from falling and avoiding the firing pin from striking the spinal cord of the experimental animal a second time.

[0021] The impact pin provided by this invention includes an impact pin body, a rotating connector, and a connecting rod. When the impact pin body moves upward under the drive of the automatic reset device, the connecting rod is locked and fixed after rotating with the positioning component around the one-way clamp. The upper end of the rotating connector rotates with the one-way rotating rod. At this time, the impact pin body will not rotate with the connecting rod, and thus the impact pin body will not be stuck in the lower limit block, so that the impact pin remains vertical and moves upward in the lower limit block.

[0022] The rotation direction of the unidirectional rotating rod provided by the present invention is limited to upward movement, which ensures that the unidirectional rotating rod remains horizontal when it falls freely downward along with the positioning component.

[0023] The present invention also provides an animal model limb fixation mechanism. When the bottom plate of the animal model fixation platform is pushed toward the firing pin, after the stop block contacts the side wall of the animal model fixation platform, it squeezes the threaded fixing rod in the automatic tightening component into the rotating cylinder, causing the rotating cylinder to rotate. The rotating cylinder then wraps the strap around itself, thereby further fixing the limbs of the animal model.

[0024] The present invention also provides an automatic release mechanism. A gear located below the base plate of the animal model fixing platform rotates, causing the base plate to move towards the firing pin. At this time, the spring is wound up. When the firing pin falls freely and strikes the spinal cord of the experimental animal, the release rod connected to the firing pin strikes the release lever. The end of the release lever near the fixing plate is lifted upward, causing the fixing plate to be released. At this time, the spring unfolds, driving the gear to rotate in the opposite direction, thereby causing the fixing plate of the animal model fixing platform to move away from the firing pin, further ensuring that the animal's spinal cord is not struck a second time. Attached Figure Description

[0025] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0026] Figure 1 This is a schematic diagram of the striking device for an animal model of spinal cord injury provided in Example 1; Figure 2 for Figure 1 A magnified view of the release lever shown; Figure 3 for Figure 1 The front view of the device shown; Figure 4 for Figure 1 A schematic diagram of the device from another perspective; Figure 5 for Figure 1 A schematic diagram of the device from another perspective; Figure 6 for Figure 5 A schematic diagram of the connecting holes shown; Figure 7 for Figure 1 The diagram shown is a structural schematic of the firing pin positioner; Figure 8 for Figure 7 A partial enlarged view of positioning component one shown; Figure 9 for Figure 8 The diagram shows the connection relationship between the horizontal sliding rod and the vertical sliding rod. Figure 10 This is a schematic diagram of the upper limit block; Figure 11 for Figure 7 A schematic diagram of the positioning component one from another perspective; Figure 12 for Figure 11 A partially enlarged view of the unidirectional mechanism shown; Figure 13 This is a structural diagram of a one-way card. Figure 14 for Figure 12 The front view of the unidirectional mechanism shown; Figure 15 This is a schematic diagram showing the connection between positioning component two and the firing pin; Figure 16 for Figure 15 The diagram shows the structure of the movable connecting rod. Figure 17 for Figure 16 A magnified view of the lower limit block shown; Figure 18 for Figure 17 The diagram shows a cross-sectional view of the automatic reset device. Figure 19 This is a structural schematic diagram of positioning component two; Figure 20 for Figure 19 The top view of positioning component two is shown; Figure 21 for Figure 20 A partially enlarged view of the drive unit shown; Figure 22 This is a schematic diagram of the slider's structure; Figure 23 for Figure 22 The diagram shows the connection between the lower layer of the slider and the transmission belt. Figure 24 A schematic diagram of the limb fixation mechanism for an animal model; Figure 25 This is a schematic diagram showing the connection between the mainspring and the gear; Figure 26 This is a schematic diagram of the automatic tightening component.

[0027] Among them, 1. Positioning component one; 11. Square slide rail; 12. Horizontal sliding rod; 13. Vertical sliding rod; 14. Upper limit block; 15. Locking nut; 16. Upper connecting block; 2. Positioning Component Two; 21. Double-layer cross slide bar; 21a. Movable rod; 21b. Control rod; 21c. Drive unit; 22. Transmission belt; 23. Lower limit block; 24. C-shaped connecting frame; 25. Lower connecting block; 26. Double C-shaped connecting rod; 27. Limiting ring; 28. L-shaped connector; 29. ​​Transmission rod; 3. Support frame; 4. Strike pin; 41. Strike pin body; 41a. Slide groove; 42. Rotating connector; 43. Connecting rod; 44. Weight; 5. Automatic resetter; 51. Sliding ring; 52. Protrusion; 6. One-way mechanism; 61. One-way rotating rod; 62. One-way clamp; 62a. Limiting cavity; 63. One-way limiting block; 63a. Limiting spring; 63b. Limiting ball; 7. Animal model fixing platform; 71. Gear; 72. Linear rack; 73. Fixing block; 74. Connecting hole; 8. Slider; 9. Animal model limb fixation mechanism; 91. Straps; 92. Stops; 93. Automatic tightening assembly; 93a. Threaded fixing rod; 93b. Rotating cylinder; 10. Automatic release mechanism; 101. Spring; 102. Release lever; 103. Release rod; 104. Movable connecting rod. Detailed Implementation

[0028] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings.

[0029] In the description of this invention, it should be understood that the terms "length direction," "upper," "lower," "front," "rear," "left," "right," "top," "bottom," "inner," "outer," "axial," "radial," and "circumferential," etc., indicating orientation or positional relationships, are based on the orientation or positional relationships shown in the accompanying drawings and are only for the convenience of describing the invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the invention. Furthermore, features limited to "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this invention, unless otherwise stated, "a plurality of" means two or more.

[0030] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances. Example 1

[0031] This embodiment provides a striking device for an animal model of spinal cord injury, such as... Figure 1-23 As shown, it includes an animal model fixing platform 7, and a firing pin positioner, a firing pin 4, an automatic resetter 5, and a one-way mechanism 6 disposed on the animal model fixing platform 7.

[0032] The animal model fixing platform 7 has a square structure with a fixing plate at the top for fixing the animal model's limbs. In actual use, the animal model's limbs can be fixed to the fixing plate using straps 91.

[0033] Among them, a straight toothed rack 72 is provided below the fixing plate.

[0034] A gear 71 is provided on the inner bottom surface of the animal model fixing platform 7; the gear 71 is located directly below the linear rack 72 and is meshed with the linear rack 72. In use, the operator can push the fixing plate, which is fixed with the animal model, to the side where the support frame 3 is located, so that the firing pin 4 can strike the spinal cord of the experimental animal.

[0035] The firing pin positioner includes a support frame 3, and positioning components 1 and 2 mounted on the support frame 3. The support frame 3 is located on one side of the animal model fixing platform 7.

[0036] The positioning component 1 includes a square sliding track 11, a horizontal sliding rod 12, a vertical sliding rod 13, an upper limit block 14, and a locking nut 15.

[0037] The structures of the transverse sliding rod 12 and the longitudinal sliding rod 13 are as follows: Figure 7 and 8 As shown, the transverse sliding rod 12 and the longitudinal sliding rod 13 are arranged in a cross shape. Specifically, the transverse sliding rod 12 and the longitudinal sliding rod 13 have the same structure, each including two parallel sliding rods, and sliding pieces are provided at both ends of the sliding rods. An upper limit block 14 is provided at the cross position of the transverse sliding rod 12 and the longitudinal sliding rod 13 to fix the upper end of the firing pin 4.

[0038] Correspondingly, the inner side of the square slide 11 is provided with a groove so that the sliding pieces of the transverse sliding rod 12 and the longitudinal sliding rod 13 can slide in the groove. When adjusting the position of the striker 4, the upper limit block 14 can be adjusted as the position of the striker 4 changes.

[0039] The structure of upper limit block 14 is as follows Figure 9 and 10 As shown, it has a double-layer structure; the upper layer is provided with a through ring for the horizontal sliding rod 12, and the lower end is provided with a through ring for the vertical sliding rod 13. In this way, the horizontal sliding rod 12 and the vertical sliding rod 13 are perpendicular to each other and are arranged in parallel vertically through the upper limit block 14.

[0040] Furthermore, in order to adjust the striking force of the firing pin 4, a weight 44 is provided at the upper end of the firing pin 4. In this way, the appropriate amount of weight 44 can be selected to adjust the striking force of the firing pin 4 according to the experimental requirements.

[0041] Positioning component 1 is connected to one-way mechanism 6.

[0042] The one-way mechanism 6 includes a one-way rotating rod 61 and a one-way locking element 62.

[0043] In practical applications, one end of the one-way rotating rod 61 is connected to the square slide rail 11 in the positioning assembly 1, and the other end is connected to the upper connecting block 16 via the one-way locking piece 62. During use, the height of the firing pin 4 can be adjusted by adjusting the height of the upper connecting block 16.

[0044] The upper connecting block 16 is threadedly connected to the support frame 3 via a locking nut 15. During use, the locking nut 5 rotates to fix the upper connecting block 16 to the support frame 3. When it is necessary to strike the spinal cord of an experimental animal, the locking nut 5 can be rotated in the opposite direction to separate the upper connecting block 16 from the support frame 3, allowing the upper connecting block 16 to fall freely with the impact pin 4 via the positioning component 1. In practical applications, only the frame 3 has a threaded hole that matches the locking nut 15.

[0045] A one-way limiting block 63 is also provided between the one-way rotating rod 61 and the one-way clamp 62, and the one-way limiting block 63 is fixedly connected to the one-way rotating rod 61; specifically, the one-way limiting block 63 includes a "6"-shaped limiting block, a limiting spring 63a, and a limiting ball 63b. The "6"-shaped limiting block is integrally connected to the one-way rotating rod 61. Specifically, the "6"-shaped limiting block has a cylindrical limiting cavity for fixing the spring 63a and the limiting ball 63b; the spring 63a is located between the limiting ball 63b and the "6"-shaped limiting block, and the spring 63a is in a compressed state.

[0046] Specifically, the one-way card 62 is provided with an arc-shaped groove and a hemispherical limiting cavity 62a at the upper end of the arc-shaped groove.

[0047] When in use, as the one-way rotating rod 61 rotates upward under the upward force of the automatic reset device 5, the spring 63a and the limiting ball 63b move upward in the arc-shaped groove on the one-way locking piece 62 until the limiting ball 63b is horizontal with the limiting cavity 62a. At this time, the limiting spring 63a returns to its initial state, squeezing the limiting ball 63b into the hemispherical limiting cavity 62a, so that the one-way rotating rod 61 and the one-way locking piece 62 are locked and fixed, thereby fixing the positioning component 1 connected to the one-way rotating rod 61 and the firing pin 4 connected to the positioning component 1.

[0048] Positioning component 2 is used to adjust the position of the firing pin 4, such as Figure 19 and 20 As shown, positioning component 2 includes a double-layer cross slide bar 21, a transmission belt 22, a lower limit block 23, a C-shaped connecting frame 24, and a lower connecting block 25. The two ends of the transmission belt 22 are fixedly connected to the lower limit block 23.

[0049] The double-layer cross slide bar 21 includes a movable rod 21a, a control rod 21b, and two drive units 21c. Specifically, the two drive units 21c are respectively located at both ends of the control rod 21b.

[0050] In practical applications, the two drive units 21c are respectively fixedly installed at both ends of the control rod 21b, and the control rod 21b is fixedly installed inside the C-shaped connecting frame 24 through the L-shaped connector; thus, in use, the control rod 21b controls the movable rod 21b to move in four directions such as front, back, left and right through the transmission belt 22, and then the movable rod drives the striker 4 to move through the lower limit block 23.

[0051] It should be noted that in this embodiment of the invention, the direction is defined as follows: the side with the support frame 3 is the left, the side with the striker 4 is the right, the side closer to the one-way mechanism 6 is the rear, and the side farther from the one-way mechanism 6 is the front.

[0052] The C-shaped connecting bracket 24 is also connected to the lower connecting block 25, which is fixedly connected to the support frame 3. Specifically, the drive unit 21c is used to control the transmission direction of the transmission belt 22. In actual use, the position of the lower limit block 23 can be adjusted by setting the rotation direction and number of rotations of the drive unit 21c.

[0053] One end of the movable rod 21a is connected to the L-shaped connector 28, and the other end is connected to the lower limit block 23.

[0054] The movable lever 21a and the control lever 21b are perpendicular to each other and are set up and down by the slider 8.

[0055] like Figure 22 and 23The diagram shows the structure of slider 8. Slider 8 has a three-layer structure. The upper layer has a through loop for movable rod 21a; the middle layer has a transmission rod 29, which limits the transmission direction of transmission belt 22, making transmission belt 22 arranged in a cross shape to control the movement position of transverse rotating rod 21a and slider 8, and is arranged parallel to transmission belt 22 and double-layer cross slide bar 21; the lower layer has a through loop for control rod 21b. Specifically, the connection between slider 8 and double-layer cross slide bar 21 is as follows: movable rod 21a passes through the through loop of the upper layer of slider 8, and longitudinal adjustment rod 21b passes through the through loop of the lower layer of slider 8. In practical applications, drive unit 21c can control transmission belt 22 to drive movable rod 21a back and forth, and thus control the movement of lower limit block 23 by the movement of movable rod 21a.

[0056] The lower limit block 23 is connected to the firing pin 4.

[0057] like Figures 15 to 18 As shown, a limiting ring is provided on the lower half of the firing pin 4 to fix the automatic resetter 5. Specifically, the limiting ring is located above the automatic resetter 5 and is connected to the automatic resetter 5.

[0058] The automatic reset device 5 includes a reset spring, the upper end of which is connected to a limit ring, and the lower end of which is provided with a sliding ring 51, which is sleeved on the firing pin 4.

[0059] Specifically, the sliding ring 51 is also provided with a protrusion 52.

[0060] Correspondingly, the side of the striker 4 near the slider of the sliding ring 51 is also provided with a groove 41a so that the protrusion 52 can slide in the groove 41a.

[0061] In practical use, when the firing pin 4 strikes the spinal cord of the experimental animal, the sliding ring 51 on the automatic reset device 5 is compressed under the limiting action of the lower limit block 23. At this time, the protrusion 52 of the sliding ring 51 is located at the highest point of the groove 41a. After the firing pin 4 strikes the spinal cord of the experimental animal, the automatic reset device 5 returns to its natural state and drives the firing pin 4 to move upward. At this time, the protrusion 52 moves towards the lower end of the groove 41a until the protrusion 52 is located at the lowest point of the groove 41a. In this way, during the upward movement of the firing pin 4 under the action of the automatic reset device 5, the protrusion 52 can prevent the firing pin 4 from falling out of the lower limit block 23.

[0062] To prevent the automatic resetter 5 from falling off the striker 4, the lower end of the striker 4 is further provided with a double C-shaped connecting rod 26 and a limiting ring 27 located below the double C-shaped connecting rod 26.

[0063] Specifically, the lower end of the outer C-shaped connecting rod 26 is connected to the limiting ring 27, and the upper end of the ring 26 holds the sliding ring 51 in place; the lower end of the inner C-shaped connecting rod is fixedly connected to the lower limiting block 23.

[0064] Application examples:

[0065] The embodiments of the present invention are illustrated using experimental rats as an example.

[0066] Animals and requirements: SD rats aged 77±5 days were selected and weighed, with a weight of 200~250g. They were acclimatized for one week and housed in individual cages.

[0067] Before establishing the model, the experimental rats were pretreated by performing a posterior laminectomy on the anesthetized animals to expose but not damage the dura mater of the mice; this included the following steps: Step 1: Anesthesia: Intraperitoneal injection anesthesia was used. The experimental rats were injected with 0.1g of 20% urethane per 100g of body weight. The rats entered anesthesia within approximately 10 minutes and remained anesthetized for 2 hours. Method for determining the degree of anesthesia: Clamp the middle of the rat's tail with hemostatic forceps. If the reflexive body movements or withdrawal response disappear, it indicates that the rat is in a state of deep anesthesia. Step Two: Laminectomy: The experimental rats were fixed in a prone position, and routine skin preparation and disinfection with 75% ethanol were performed. A midline incision of approximately 4 cm was made along the spine, centered on the T10 spinous process (the highest point of the rat's spinous process). The skin was cut open, and the subcutaneous tissue was dissected layer by layer. The paravertebral muscles were bluntly dissected and hemostasis was achieved. An ophthalmic retractor was used to open the paravertebral muscles, exposing the T10 spinous process and lamina. The ligamentum flavum was cut along the intervertebral space, and the spinous process and lamina were removed with bone forceps, completely exposing the spinal cord. Step 3: Use the spinal clamps of the striking device to clamp the T8 and T11 spinous processes respectively, suspending part of the rat's body in the air. Place gauze under the body to prevent the rat from tilting but to prevent it from tilting, but to ensure it does not support the rat's weight. The striking device should be vertically downward and aligned with the center of impact. The establishment of an animal model includes the following steps: Step 4: Fix the limbs of the treated experimental rats to the fixation plate of the animal model fixation platform 7 using straps 92; Step 5: Slide the fixing plate on the animal model fixing platform 7 toward the side where the firing pin 4 is located, so that the animal model is located below the firing pin 4, and the spinous process of the T10 spine of the experimental rat is directly below the firing pin 4. Step 6: Adjust the movable rod 21a and control rod 21b in positioning component 2 so that the striking pin 4 is located directly above the striking position of the experimental rat's spinal cord; This step involves four scenarios: Case 1: If the drive unit 21c located in front of the slider 8 rotates clockwise and the other drive unit 21c rotates counterclockwise, the length of the transmission belt 22 located on the right side of the slider 8 will become shorter and the length of the transmission belt 22 on its left side will become longer. That is, the transmission belt 22 drives the movable rod 21a to move to the left side of the slider 8, and the movable rod 21a drives the impact pin 4 to move to the left through the lower limit block 23. Case 2: If the drive unit in front of the slider 8 rotates counterclockwise and the other drive unit rotates clockwise, the length of the transmission belt 22 on the right side of the slider 8 will increase and the length of the transmission belt 22 on its left side will decrease. In this way, the transmission belt 22 will drive the movable rod 21a to move to the right side of the slider 8, and the movable rod 21a will drive the impact pin 4 to move to the right through the lower limit block 23. Case 3: If the drive unit in front of the slider 8 rotates clockwise and the other drive unit rotates clockwise, the length of the transmission belt 22 behind the slider 8 will increase and the length of the transmission belt 22 in front of the slider 8 will decrease. In this way, the transmission belt 22 will drive the movable rod 21a to move forward of the slider 8, and then the movable rod 21a will drive the impact pin 4 to move forward through the lower limit block 23. Case 4: If the drive unit in front of the slider 8 rotates counterclockwise and the other drive unit rotates counterclockwise, the length of the transmission belt 22 in front of the slider 8 will increase, and the length of the transmission belt 22 behind it will decrease. In this way, the transmission belt 22 will drive the movable rod 21a to move backward, and then the movable rod 21a will drive the impact pin 4 to move backward through the lower limit block 23. Step 7: Wipe the clubhead with 75% alcohol before hitting and let it air dry. Step 8: Loosen the locking nut 12 and adjust the height of the positioning component 1 so that the firing pin 4 is at a height of 25 mm from the impact point; Step 9: Release the locking nut 15, allowing the upper connecting block 16 to fall freely. Then, the upper connecting block 16 drives the firing pin 4 to fall freely through the upper positioning component 1. At this time, the lower end of the firing pin 4 passes through the lower limit block 23 and impacts the spinal cord of the experimental rat.

[0068] Step Nine: During the process of the impact pin 4 striking the spinal cord of the experimental rat, the automatic reset device 5 is compressed under the limiting action of the lower limit block 23. Then, after the impact pin 4 strikes the spinal cord of the experimental rat once, the automatic reset device 5 returns to its initial state, driving the impact pin 4 to move upward. At the same time, the impact pin 4 gives the positioning component 1 an upward force, causing the positioning component 1 to rotate with the one-way rotating rod 61 around the one-way clamp 62. Step 10: Under the upward force of the positioning component 1, the one-way rotating rod 61 rotates upward around the one-way clamp 62 until the limiting ball 63b is at the same horizontal level as the limiting cavity 62a of the one-way clamp 62. Then, under the action of the limiting spring 63a, the limiting ball 63b is squeezed into the limiting cavity 62a, so that the one-way rotating rod 61 and the one-way clamp 62 are fixedly connected. At this time, the one-way rotating rod 61 fixes the firing pin 4 through the positioning component 1 to prevent the firing pin 4 from hitting the spinal cord of the experimental rat a second time. After the impact, the dural veins of the experimental rat will be locally congested and thickened, and turn purplish-red. At the time of the impact, the rat's tail will spasm and its lower limbs and body will retract and flap. After the operation, the rat's lower limbs will be flaccid paralyzed. At this time, the animal model is successfully established.

[0069] After the spinal cord impact experiment on the rats was completed, the rats were quickly removed and reinserted into the surgical area, and the muscles and skin were sutured layer by layer. Example 2

[0070] Based on Example 1, the difference from Example 1 is as follows: Figure 15 As shown, the firing pin 4 provided in this embodiment of the invention includes a firing pin body 41, a rotating connector 42, and a connecting rod 43.

[0071] Specifically, the firing pin body 41 is connected to the connecting rod 43 via a rotating connector 42. The automatic reset device 5 is sleeved on the outside of the firing pin body 41.

[0072] When in use, after the firing pin body 41 strikes the experimental animal, the firing pin body 41 moves vertically upward under the action of the automatic reset device 5.

[0073] The connecting rod 43 is fixedly connected to the positioning component 1. After the connecting rod 43 is subjected to an upward force by rotating the connecting piece 42, it rotates upward with the unidirectional rotating rod 61.

[0074] Therefore, during the upward movement of the firing pin 4, the firing pin body 41 and the connecting rod 43 form a V-shaped structure, so that the firing pin body 41 will not get stuck in the lower limit block 23, ensuring that the firing pin 4 moves vertically upward. Example 3

[0075] Based on Embodiment 1, unlike Embodiments 1 and 2, the striking device for the spinal cord injury animal model provided in this embodiment of the invention further includes a limb fixation mechanism 9 for the animal model.

[0076] The animal model limb fixation mechanism 9 includes two sets of fixation components, each set of fixation components including: straps 91, stops 92 and automatic tightening components 93.

[0077] The automatic tightening assembly 93 includes a threaded fixing rod 93a and a rotating cylinder 93b. The strap 91 passes through the fixing plate in the animal model fixing platform 7 used to fix the animal model and is then fixedly mounted on the rotating cylinder 93b. In practical applications, each rotating cylinder 93b is equipped with one strap 91.

[0078] The threaded fixing rod 93a has threads on its surface.

[0079] The rotating cylinder 93b has a cylindrical structure, and its inner surface is provided with a threaded slide that matches the threaded fixing rod 93a.

[0080] Specifically, one end of the threaded fixing rod 93a is connected to the stop block 92 via a push rod, and the other end is inserted into the interior of the rotating cylinder 93b and matched with the threaded slide of the rotating cylinder 93b; thus, during use, under the action of the threads on the surface of the threaded fixing rod 93a, the rotating cylinder 93b now rotates around itself.

[0081] Thus, when the fixing plate in the animal model fixing platform 7 moves toward the side with the support frame 3, after the stop block 92 contacts the side wall of the animal model fixing platform 7, it drives each threaded fixing rod 93a to move toward the inside of the rotating cylinder 93b through the push rod. In this way, after the stop block 92 contacts the side wall of the animal model fixing platform 7, the four straps 91 set on the fixing plate are all tightened at the same time.

[0082] Based on this, a fixing block 73 is provided at the lower end of the fixing plate for fixing the rotating cylinder 93b.

[0083] In use, the operator pushes the fixing plate toward the end with the support frame 3. The stop block 92 first touches the side wall of the animal model fixing platform 7, and then the stop block 92 moves toward the side with the automatic tightening component 93. In this way, the stop block 92 pushes each threaded fixing rod 93a into the rotating cylinder 93b through the push rod, so that the rotating cylinder 93b rotates through the threaded slide on its inner side, and then wraps the strap 91 around the rotating cylinder 93b to further tighten the straps binding the limbs of the animal model.

[0084] Application examples:

[0085] Based on the application case of Embodiment 1, the steps in this embodiment differ from those in the application case of Embodiment 1. In step four, the following is also included: when the operator pushes the animal model fixing platform 7 below the firing pin 4, the stop block 92 touches the side wall of the animal model fixing platform 7 and squeezes the automatic tightening component 93. The stop block 92 pushes the threaded fixing rod 93a into the rotating cylinder 93b through the push rod, causing the rotating cylinder 93b to rotate, thereby wrapping the strap 91 around the side of the rotating cylinder 93b, so that the strap 91 binding the limbs of the experimental rat is further tightened. Example 4

[0086] Based on Example 1, the difference from Examples 1, 2, and 3 is that, Figure 2 and 25 As shown, the striking device for the spinal cord injury animal model provided in this embodiment of the invention also includes an automatic release mechanism 10.

[0087] The automatic release mechanism 10 includes a spring 101, a release lever 102, and a release rod 103.

[0088] Specifically, such as Figure 25 As shown, the spring 101 and the gear 71 are coaxially arranged; thus, while the gear 71 rotates to push the fixing plate into the animal model fixing platform 7, the spring 101 winds up.

[0089] Release lever 102 is set as follows Figure 2 The release lever 102 is located on the side wall of the animal model fixing platform 7 at the position shown.

[0090] Correspondingly, such as Figure 6 As shown, the side of the fixing plate is provided with a connecting hole 74 that mates with the release lever 102. The connecting hole 74 and the release lever 102 are located on the same center line.

[0091] In actual use, when the operator pushes the fixing plate under the firing pin 4, the lever 102 is released to connect with the connecting hole 74, so that the fixing plate is fixed under the firing pin 4.

[0092] like Figure 5 As shown, the release lever 103 is positioned directly above the release paddle 102, and its upper end passes through the lower connecting block 23.

[0093] like Figure 16 As shown, during the free fall of the firing pin 4, the firing pin 4 drives the release rod 103 to fall freely simultaneously via the movable connecting rod 104. Until the release rod 103 descends to the lowest point, it presses down the outer edge of the release lever 102. At this time, the end of the release lever 102 located inside the animal model fixing platform 7 tilts upward, causing the release lever 102 to disengage from the connecting hole 74, thereby releasing the spring 101 from its wound state. In this way, the spring 101 drives the gear 71 to rotate in the opposite direction, thereby causing the linear rack 72, which is meshed with the gear 71, to move in the opposite direction, causing the fixing plate to be pushed out. This achieves the following: after the firing pin 4 strikes the spinal cord of the experimental animal, the automatic reset device 5 and the one-way mechanism 6 move the firing pin 4 upward and fix it. Then, the automatic release mechanism 10 pushes the fixing plate outward, further preventing the firing pin 4 from striking the spinal cord of the experimental animal a second time.

[0094] Application examples:

[0095] Based on the application case of Embodiment 1, the difference between this embodiment and the application case of Embodiment 1 is that step nine in the application case of Embodiment 1 includes: Release the locking nut 15 to allow the upper connecting block 16 to fall freely. Then, the upper connecting block 16 drives the firing pin 4 to fall freely through the upper positioning component 1. At this time, the lower end of the firing pin 4 passes through the lower limit block 23 and impacts the spinal cord of the experimental rat. During the process of the impact pin 4 striking the spinal cord of the experimental rat, the automatic reset device 5 is compressed under the action of the lower limit block 23. Then, after the impact pin 4 strikes the spinal cord of the experimental rat once, the automatic reset device 5 returns to its initial state, driving the impact pin 4 to move upward. In this way, the impact pin 4 gives the positioning component 1 an upward force, causing the positioning component 1 to rotate upward with the one-way rotating rod 61 around the one-way clamp 62. During the process of the impact pin 4 striking the spinal cord of the experimental rat, the release rod 103 falls freely with the impact pin 4 via the movable connecting rod 104. After the impact pin 4 strikes the spinal cord of the experimental animal, the release rod 103 strikes the release lever 102 downwards, and the release lever 102 disengages from the connecting hole 74. That is, the release lever 102 releases the spring 101 from the wound state through the fixed plate. In this way, the spring 101 drives the fixed plate to rotate in the opposite direction of the driving gear 71, and then the linear rack 72, which is meshed with the gear 71, moves in the opposite direction, so that the fixed plate is pushed out. This achieves the goal of pushing out the fixed plate after the automatic reset device 5 and the one-way mechanism 6 have moved the impact pin 4 upwards and fixed it, further preventing the impact pin 4 from striking the spinal cord of the experimental animal a second time.

[0096] The contents not described in detail in this specification are existing technologies known to those skilled in the art.

Claims

1. A striking device for an animal model of spinal cord injury, comprising: The firing pin (4) and the animal model fixing platform (7) are characterized in that they further include: The firing pin positioner includes a support frame (3) and a positioning component one (1) and a positioning component two (2) disposed on the support frame (3) respectively. The positioning component 1 is located at the upper end of the striker (4) and is used to control the striker (4) to fall freely. The second positioning component (2) is located at the lower end of the firing pin (4) and is vertically positioned above the animal model fixing platform (7) to adjust the direction of the firing pin striking the spinal cord of the experimental animal; An automatic resetter (5) is located at the lower end of the striker (4) and connected to the second positioning component (2). It is used to drive the striker (4) to move upward after the striker (4) falls and hits the spinal cord of the animal. A one-way mechanism (6) is disposed between the positioning component (1) and the support frame (3) for fixing the positioning component (1) when the firing pin (4) drives the positioning component (1) to move upward.

2. The striking device for a spinal cord injury animal model according to claim 1, characterized in that, The one-way mechanism (6) includes: a one-way rotating rod (61) and a one-way locking element (62); One end of the unidirectional rotating rod (61) is connected to the positioning component (1), and the other end is connected to the support frame (3) through the unidirectional clamp (62).

3. The striking device for a spinal cord injury animal model according to claim 2, characterized in that, The firing pin (4) includes: firing pin body (41), rotating connector (42) and connecting rod (43). One end of the connecting rod (43) is connected to the positioning component (1), and the other end is connected to the firing pin body (41) through the rotating connector (42).

4. The striking device for a spinal cord injury animal model according to claim 2, characterized in that, The positioning component two (2) includes a double-layer cross slide bar (21), a transmission belt (22), and a lower limit block (23): One end of the double-layer cross slide bar (21) is connected to the lower limit block (23), and the other end is connected to the support frame (3); The transmission belt (22) is mounted on the double-layer cross slide bar (21) and is used to adjust the position of the lower limit block (23).

5. The striking device for a spinal cord injury animal model according to claim 4, characterized in that, The double-layer cross slide bar (21) includes: a movable rod (21a), a control rod (21b), and two drive units (21c); the movable rod (21a) and the control rod (21b) are perpendicular to each other and arranged vertically by a slider (8); The movable rod (21a) is connected to the lower limit block (23); The two drive units (21c) are respectively disposed at both ends of the control rod (21b) and connected to the transmission belt (22). The position of the lower limit block (23) is adjusted by controlling the transmission direction of the transmission belt (22).

6. The striking device for a spinal cord injury animal model according to claim 5, characterized in that, The positioning component (1) includes a square slide rail (11), and a transverse sliding rod (12) and a longitudinal sliding rod (13) disposed in the square slide rail (11); the transverse sliding rod (12) and the longitudinal sliding rod (13) are connected by an upper limit block (14); The upper end of the firing pin (4) is located inside the upper limit block (14).

7. The striking device for a spinal cord injury animal model according to claim 6, characterized in that, The animal model fixing platform (7) is also provided with an animal model limb fixing mechanism (9) on its lower side. The animal model limb fixation mechanism (9) includes straps (91), stops (92) and automatic tightening components (93). The strap (91) is connected to the automatic tightening assembly (93); One end of the automatic tightening component (93) is connected to the stop block (92), and the other end is fixedly installed at the lower end of the animal model fixing platform (7).

8. The striking device for a spinal cord injury animal model according to claim 7, characterized in that, It also includes an automatic release mechanism (10), comprising: a spring (101) and a release lever (102); The release lever (102) is located on the side of the animal model fixing platform (7) near the support frame (3); The spring (101) is disposed on the bottom surface of the animal model fixing platform (7) and is arranged along the same center line as the spring (101).

9. The striking device for a spinal cord injury animal model according to claim 7, characterized in that, It also includes a release lever (103); The release rod (103) is located on one side of the support frame (3) and is fixedly connected to the firing pin (4).

10. The method of operating the striking device for a spinal cord injury animal model as described in any one of claims 1-9, characterized in that, Step 1: Fix the limbs of the experimental animal to the animal model fixing platform (7) with straps (91); Step 2: Push the animal model fixing platform (7) to the bottom of the firing pin (4). After the stop block (92) touches the side wall of the animal model fixing platform (7), it squeezes the automatic tightening component (93). The automatic tightening component (93) further tightens the strap (91) and fixes the experimental animal. Step 3: Set the rotation direction and number of rotations of the drive units (21c) at both ends of the control lever (21b) to locate the position of the impact pin (4) on the spinal cord of the experimental animal; Step 4: Release positioning component 1 (1), and the firing pin (4) connected to positioning component 1 (1) falls freely to strike the spinal cord of the experimental animal; Step 5: After the impact pin (4) strikes the spinal cord of the experimental animal once, the automatic reset device (5) drives the impact pin (4) and the positioning component 1 (1) connected to the impact pin (4) to move upward; Step 6: The one-way rotating rod (61) connected to the positioning component (1) rotates after being subjected to an upward force. The one-way rotating rod (61) and the one-way locking piece (62) are locked together. The positioning component (1) and the firing pin (4) connected to the positioning component (1) are fixed to prevent the secondary firing pin from falling and hitting the spinal cord of the experimental animal. At this time, the animal model is successfully established.

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