Repair gel containing PDRN and preparation method thereof
By using a simple PDRN repair gel formulation and preparation method, the problems of high cost and limited use on sensitive skin have been solved, achieving low-cost and easily accessible skin repair effects.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- 碧研生物科技(江苏)有限公司
- Filing Date
- 2024-11-12
- Publication Date
- 2026-05-12
AI Technical Summary
Existing repair gels have complex ingredients, resulting in high costs, making them unsuitable for sensitive skin, limiting their applicability, and their processing is cumbersome, making them difficult to popularize.
The PDRN repair gel formula uses simple ingredients, including PDRN, recombinant humanized collagen, trehalose, glycerin, carbomer, hexanediol, capryloyl hydroxamic acid, and water. It is prepared through steps such as stirring, fine filtration, and pH adjustment to ensure product safety and ease of distribution.
It achieves low-cost, skin-friendly repair effects, expands the scope of application, simplifies the processing technology, reduces production difficulty, and increases product popularity.
Abstract
Description
Technical Field
[0001] This invention relates to the field of medical device manufacturing technology, specifically to a repair gel containing PDRN and its preparation method. Background Technology
[0002] Regenerative medicine is the science that studies the characteristics and functions of normal tissues, mechanisms of wound repair and regeneration, and cell differentiation mechanisms to find effective biological therapies and engineering methods to promote the body's self-repair and regeneration, or to construct new tissues and organs to improve or restore the function of damaged tissues and organs. Using the advanced knowledge and achievements of regenerative medicine to improve the medical level and quality of cosmetic medicine; exploring and discovering new biomedical technologies and methods in cosmetic medicine; and establishing transformation methods, organizational models, and market mechanisms for cosmetic medical biomedical technologies will be one of the important missions, goals, and tasks of the beauty industry.
[0003] Polydeoxyribonucleotides (PDRN), as essential genetic material for organisms, are the nucleic acids most similar to human DNA known to date. PDRN activates the DNA activity of aging cells, improves skin microcirculation, shortens the skin cell metabolism cycle, promotes collagen secretion deep within the skin, and builds youthful, healthy skin. However, obtaining safe and reliable repair and regeneration skincare products with good transdermal absorption, enhanced efficacy, and reduced side effects remains an urgent problem to be solved.
[0004] The ingredients in repair gels are too complex and diverse, resulting in high costs and prices. At the same time, due to the complexity of the ingredients, people with sensitive skin cannot use them, thus limiting their widespread availability. Summary of the Invention
[0005] The purpose of this invention is to address the shortcomings and deficiencies of existing technologies by providing a reasonably designed PDRN-containing repair gel and its preparation method. The gel has simple ingredients, low cost, is not resistant to sensitive skin, increases its applicability, and has a simple, uncomplicated processing technology that is easy to popularize.
[0006] To achieve the above objectives, the PDRN repair gel of the present invention comprises the following components by weight percentage: PDRN 0.05-1.0 parts, recombinant humanized collagen 0.01-0.3 parts, trehalose 5.0-8.0 parts, glycerol 1.0-8.0 parts, carbomer 0.05-0.8 parts, ethylene glycol 0.1-0.2 parts, capryloyl hydroxamic acid 0.02-0.12 parts, triethanolamine 0.05-0.8 parts, and water 80.78-93.72 parts.
[0007] Furthermore, the repair gel comprises the following components by weight percentage: PDRN 0.05–1.0 parts, recombinant humanized collagen 0.01–0.3 parts, trehalose 5.0–8.0 parts, glycerin 1.0–8.0 parts, carbomer 0.05–0.8 parts, hexanediol 0.1–0.2 parts, capryloyl hydroxamic acid 0.02–0.12 parts, triethanolamine 0.05–0.8 parts, and water 80.78–93.72 parts.
[0008] Furthermore, the repair gel is characterized in that: the PDRN is a salmon testis extract with a molecular weight of 50KD to 350KD.
[0009] The preparation method of the repair gel of the present invention is as follows: Step (1): Add 0.05-1.0 parts of PDRN, 0.01-0.3 parts of recombinant humanized collagen, 5.0-8.0 parts of trehalose, 1.0-8.0 parts of glycerol, 0.1-0.2 parts of ethylene glycol, and 0.02-0.12 parts of capryloyl hydroxamic acid to a stirred tank, and add 80.78-93.72 parts of water and stir to dissolve. Step (II): Add 0.05 to 0.8 parts of carbomer to the mixture formed in step (I), stir to dissolve, and obtain a swollen carbomer mother liquor.
[0010] Step (3): Filter the mixed solution from step (2) in a fine filtration device.
[0011] Step (iv): Add 0.05 to 0.8 parts of triethanolamine to the solution from step (iii) and adjust the pH to obtain the PDRN repair gel. Step (5): Fill the PDRN repair gel that meets the testing standards using filling equipment, then package it in a box using packaging equipment, and finally code and put it into the warehouse.
[0012] Furthermore, before use, the fine filtration equipment in step three is disinfected and sterilized internally using an ultraviolet disinfection lamp.
[0013] With the above structure, the beneficial effects of the present invention are: the present invention provides a repair gel containing PDRN and its preparation method, which has simple ingredients, low cost, does not reject sensitive skin, increases the scope of application, and the processing technology is simple, not complicated, and easy to popularize. Detailed Implementation
[0014] The repair gel in this specific embodiment (Example 1) comprises the following components by weight percentage: PDRN 1.0 part, recombinant humanized collagen 0.3 part, trehalose 8.0 part, glycerin 8.0 part, carbomer 0.8 part, ethylene glycol 0.2 part, capryloyl hydroxamic acid 0.12 part, triethanolamine 0.8 part, and water 80.78 parts.
[0015] The preparation method of the repair gel in this specific embodiment is as follows: Step (1): Add 1.0 part of PDRN, 0.3 part of recombinant humanized collagen, 8.0 part of trehalose, 8.0 part of glycerol, 0.2 part of ethylene glycol, and 0.12 part of capryloyl hydroxamic acid to a mixing vessel, add 80.78 parts of water and stir to dissolve; Step (II): Add 0.8 parts of carbomer to the mixture formed in step (I), stir to dissolve, and obtain a swollen carbomer mother liquor.
[0016] Step (3): Filter the mixed solution from step (2) in a fine filtration device.
[0017] Step (IV): Add 0.8 parts of triethanolamine to the solution from step (III), adjust the pH, and take a sample for testing; this yields the PDRN repair gel. Step 3: First, use an ultraviolet disinfection lamp to disinfect and sterilize the inside. Then, send the crude product liquid obtained in Step 2 into a fine filtration device for fine filtration twice to remove impurities and residue. Step 4: Fill the filtrate that meets the testing standards using filling equipment, then package it in boxes using packaging equipment, and finally code and put it into storage.
[0018] The working principle of this specific embodiment is as follows: The main component of the repair gel is water. It utilizes the anti-inflammatory and repairing properties of PDRN to achieve an anti-inflammatory and repairing effect; it utilizes the water-locking properties of trehalose to lock in and retain the water of the main component on the skin, resulting in a high moisturizing effect; it utilizes recombinant humanized collagen to achieve the purpose of water retention and anti-aging; the entire repair gel has a simple composition, is friendly to sensitive skin, has low cost, and is easy to process.
[0019] The beneficial effects of this specific embodiment after adopting the above process are as follows: This specific embodiment provides a repair gel containing PDRN and its preparation method. Its ingredients are simple, the cost is low, it is not rejected by sensitive skin, the scope of application is increased, and the processing technology is simple, not complicated, and easy to popularize. Example
[0020] The repair gel in this embodiment comprises the following components by weight percentage: 0.05 parts PDRN, 0.01 parts recombinant humanized collagen, 5.0 parts trehalose, 1.0 part glycerol, 0.05 parts carbomer, 0.1 parts hexanediol, 0.02 parts capryloyl hydroxamic acid, 0.05 parts triethanolamine, and 93.72 parts water.
[0021] The preparation method of the repair gel in this embodiment is as follows: Step (1): Add 0.05 parts of PDRN, 0.01 parts of recombinant humanized collagen, 5.0 parts of trehalose, 5.0 parts of glycerol, 0.1 parts of ethylene glycol, and 0.02 parts of capryloyl hydroxamic acid to a mixing vessel, add 93.72 parts of water and stir to dissolve; Step (II): Add 0.05 parts of carbomer to the mixture formed in step (I), stir to dissolve, and obtain a swollen carbomer mother liquor.
[0022] Step (3): Filter the mixed solution from step (2) in a fine filtration device.
[0023] Step (iv): Add 0.05 parts of triethanolamine to the solution from step (iii), adjust the pH, and take a sample for testing; this yields the PDRN repair gel. Step 3: First, use an ultraviolet disinfection lamp to disinfect and sterilize the inside. Then, send the crude product liquid obtained in Step 2 into a fine filtration device for fine filtration twice to remove impurities and residue. Step 4: Fill the filtrate that meets the testing standards using filling equipment, then package it in boxes using packaging equipment, and finally code and put it into storage.
[0024] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.
Claims
1. A repair gel containing PDRN and its preparation method, characterized in that: It comprises the following components by weight percentage: PDRN 0.05–1.0 parts, recombinant humanized collagen 0.01–0.3 parts, trehalose 5.0–8.0 parts, glycerol 1.0–8.0 parts, carbomer 0.05–0.8 parts, hexanediol 0.1–0.2 parts, capryloyl hydroxamic acid 0.02–0.12 parts, triethanolamine 0.05–0.8 parts, and water 80.78–93.72 parts.
2. The PDRN-containing repair gel and its preparation method according to claim 1, characterized in that: The repair gel comprises the following components by weight percentage: PDRN 0.05-1.0 parts, recombinant humanized collagen 0.01-0.3 parts, trehalose 5.0-8.0 parts, glycerol 1.0-8.0 parts, carbomer 0.05-0.8 parts, ethylene glycol 0.1-0.2 parts, capryloyl hydroxamic acid 0.02-0.12 parts, triethanolamine 0.05-0.8 parts, and water 80.78-93.72 parts.
3. The PDRN-containing repair gel according to claim 1, characterized in that: The PDRN is a salmon testis extract with a molecular weight of 50KD to 350KD.
4. A method for preparing a repair gel containing PDRN, characterized in that: Step (1): Add 0.05-1.0 parts of PDRN, 0.01-0.3 parts of recombinant humanized collagen, 5.0-8.0 parts of trehalose, 1.0-8.0 parts of glycerol, 0.1-0.2 parts of ethylene glycol, and 0.02-0.12 parts of capryloyl hydroxamic acid to a stirred tank, and add 80.78-93.72 parts of water and stir to dissolve. Step (II): Add 0.05 to 0.8 parts of carbomer to the mixture formed in step (I), stir to dissolve, and obtain a swollen carbomer mother liquor.
5. Step (III): Filter the mixed solution from step (II) in a fine filtration device.
6. Step (IV): Add 0.05-0.8 parts of triethanolamine to the solution from step (III) and adjust the pH to obtain the PDRN repair gel. Step (5): Fill the PDRN repair gel that meets the testing standards using filling equipment, then package it in a box using packaging equipment, and finally code and put it into the warehouse.
7. The method for preparing a PDRN-containing repair gel according to claim 5, characterized in that: Before use, the fine filtration equipment in step (iii) is disinfected and sterilized using an ultraviolet disinfection lamp.