Targeted antiperspirant

Abstract

The invention provides a targeted antiperspirant, and relates to the technical field of targeted antiperspirants. The preparation method of the targeted antiperspirant specifically comprises the following steps: (1) preparing a chelating protective agent; (2) preparing an aluminum chlorohydrate activating solution; (3) preparing blank micelles; (4) micelle loading; (5) cooling and curing; and (6) emulsification preparation. According to the technology, the self-assembly characteristic of poloxamer 407 is utilized, micelles with the particle size of about 20nm are formed through self-assembly, the micelles are disintegrated at the skin temperature and release aluminum chlorohydrate nanogel clusters through nucleation and efficient entrapment of aluminum chlorohydrate hydrolysis intermediates, the micelles are crosslinked into a porous physical membrane after encountering sweat, sweat gland ducts are reversibly blocked, and the effect of inhibiting the sweat gland ducts is achieved. According to the present invention, with the application of the bisabolol, the sweat can be prevented from being smoothly discharged to the skin surface so as to achieve the efficient sweat stopping effect, the inulin and the antibacterial component are added to maintain the balance of the armpit flora, the sweat stopping and the deodorization are combined, and the bisabolol can be efficiently fused so as to relieve the skin and strengthen the skin barrier during the nursing.

Description

Technical Field

[0001] This invention relates to the field of targeted antiperspirant technology, specifically to a targeted antiperspirant. Background Technology

[0002] Antiperspirants are personal care products used to reduce sweating. Their main active ingredient is usually an aluminum salt compound (such as aluminum hydroxychloride). Their core function is not to completely stop sweating—which is crucial for heat dissipation and health—but rather to temporarily "block" sweat gland ducts by mixing with sweat on the skin's surface, forming a gel-like substance. This significantly reduces sweat production in specific areas, such as the armpits. Reduced sweating has multiple benefits: firstly, it controls the discomfort and embarrassment caused by hyperhidrosis or excessive daily sweating, keeping the skin dry; secondly, it effectively prevents body odor caused by bacteria growing in a sweaty environment, as most antiperspirants also have deodorizing properties, with antibacterial ingredients in their formula breaking down or masking odors. Therefore, it not only improves personal comfort and confidence but also prevents sweat stains from damaging clothing.

[0003] Current antiperspirant technologies rely on active ingredients such as aluminum hydroxychloride and aluminum zirconium glycinate to hydrolyze and cross-link in sweat, forming a physical gel that blocks sweat ducts and thus achieves an antiperspirant effect. Generally, the active ingredients are dispersed or dissolved in matrices such as alcohol, water, silicone oil, and esters, and then prepared into emulsions or emulsions through conventional processes such as emulsification and thickening. Traditional antiperspirant processes are relatively "passive" and "direct." Aluminum salt particles diffuse randomly to the skin and sweat glands based on concentration gradients, with a large number of aluminum ions directly contacting the skin surface, causing skin irritation. Furthermore, the active ingredients easily react with substances on the skin surface, resulting in rapid loss and a lack of precise spatiotemporal control, thus leading to a short duration of action. This new technology utilizes the self-assembly of poloxamer and active ingredients to form nanomicelles. Under specific conditions (skin temperature, sweat pH), these micelles undergo structural transformation, activating and releasing the antiperspirant ingredients. This achieves better antiperspirant effects with lower concentrations, while the self-assembled nanocomposite gel has stronger adhesion to sweat ducts, resulting in a longer-lasting effect and significantly reduced skin irritation. Summary of the Invention

[0004] In view of the shortcomings of the prior art, the present invention provides a targeted antiperspirant that solves the problems of poor efficacy, short duration of action and strong skin irritation of traditional antiperspirants.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a method for preparing a targeted antiperspirant, specifically comprising the following steps: (1) Preparation of chelating protectant: Dissolve 0.1 parts of disodium EDTA, 0.8 parts of triethyl citrate and 5 parts of dipropylene glycol in 10 parts of water by mass, and stir at 60°C to form a transparent solution; (2) Preparation of activated aluminum hydroxychloride solution: Add 8 parts of aluminum hydroxychloride to the solution obtained in step (1), and add saturated sodium bicarbonate solution under high speed to adjust the pH to 6.0; (3) Preparation of blank micelles: Dissolve 3 parts of poloxamer 407 in 57 parts of deionized water and refrigerate at 4°C while stirring until a transparent blank micelle solution is formed; (4) Micelle loading: The blank micelle solution obtained in step (3) is heated to 15°C, and the activation solution obtained in step (2) is added. The temperature is increased to 37°C at a rate of 1°C / min under stirring at 300 rpm, and kept warm and stirred for 30 minutes so that Al³⁺ is loaded into the hydrophobic core of the micelles. (5) Cooling and solidification: Cool the system obtained in step (4) to 25°C, add 1.5 parts of trehalose and 10 parts of dipropylene glycol, stir to dissolve, and obtain a micelle dispersion; (6) Emulsion preparation: Dissolve 2 parts of inulin in 88.595 parts of deionized water and mix well; separately, mix 0.2 parts of bisabolol, 0.3 parts of peppermint oil, 0.005 parts of rose fragrance, 1.2 parts of phenoxyethanol, 0.7 parts of hexylhexylglycerin and 2 parts of emulsifier WR-H07 by hot melting, add to the inulin aqueous solution, homogenize at high speed and cool to room temperature, and finally add 8 parts of the micelle dispersion obtained in step (5) and mix well to obtain the targeted antiperspirant.

[0006] Preferably, the targeted antiperspirant prepared by the method has a pH value of 6.0-6.5.

[0007] Preferably, the average particle size of the nanomicelles of the active ingredient in the targeted antiperspirant prepared by the method is 20 nm to 150 nm.

[0008] Preferably, in the targeted antiperspirant prepared by the method, at skin temperature, the nanomicelles dissociate and release aluminum hydroxychloride nanogel clusters, which crosslink to form a porous physical membrane under sweat pH>6.5 conditions to reversibly block the sweat gland ducts.

[0009] Preferably, the inulin is used to regulate the skin's microbiome balance, and the bisabolol is used to soothe the skin and repair the skin barrier.

[0010] A method for evaluating the antiperspirant effect of a targeted antiperspirant, comprising the following steps: (a) The antiperspirant is evenly coated onto filter paper and dried to form a film; (b) Artificial simulated sweat was dropped onto the film-forming area, and the time it took for the sweat to penetrate the filter paper and the lateral diffusion diameter were recorded. (c) The antiperspirant effect was evaluated by penetration time and diffusion diameter.

[0011] This invention provides a targeted antiperspirant. It has the following beneficial effects: This invention provides a targeted antiperspirant. Compared to traditional antiperspirant preparation processes, this invention utilizes the self-assembly of poloxamer 407 and an aluminum chloride hydrolysis intermediate to form nanomicelles. These nanomicelles release antiperspirant components at specific sweat pH and body temperature, delivering them more efficiently to the openings of hair follicles and sweat glands. Because poloxamer 407 undergoes a sol-to-gel transition at 33°C, the emulsion viscosity increases at skin temperature, enhancing drug retention on the skin. This reduces the frequency of application for patients with bromhidrosis or excessive sweating, resulting in highly effective antiperspirant action. Simultaneously, it reduces skin irritation caused by high doses of aluminum salts. To make the product gentler on the skin, the pH value of the lotion is adjusted to within the optimal range for the skin. The addition of bisabolol also provides anti-inflammatory, soothing, and skin-repairing effects, making it suitable for people with fragile or sensitive skin who experience excessive sweating or body odor. Furthermore, in addition to its outstanding antiperspirant effect, the addition of a certain amount of inulin in the formula helps regulate the skin's flora, significantly inhibiting harmful bacteria, promoting the growth of beneficial bacteria, and improving the overall health of the skin. Therefore, compared to traditional processes, this invention offers a more efficient and longer-lasting antiperspirant effect, while also possessing antibacterial and skin-soothing properties, providing a more efficient, safer, and more comfortable experience for people with excessive sweating or body odor. Attached Figure Description

[0012] Figure 1 This is a schematic diagram of the final emulsion of the present invention; Figure 2 This is a schematic diagram of the light blue opalescent dispersion of the present invention; Figure 3 This is a schematic diagram of the sample and control group after drying at 40°C according to the present invention; Figure 4 A schematic diagram showing the diffusion results of the artificial sweat of the present invention after being dropped onto filter paper for 30 seconds; Figure 5 A schematic diagram showing the diffusion results of the artificial sweat of the present invention after being dropped onto filter paper for 150 seconds; Figure 6 This is a schematic diagram showing the final diffusion result of the artificial sweat of the present invention after it is dripped onto filter paper; Figure 7 This is a schematic diagram of the undiluted particle size of the present invention; Figure 8 This is a schematic diagram of the undiluted Zeta potential of the present invention; Figure 9 This is a schematic diagram of the antiperspirant product of the present invention; Figure 10 This is a schematic diagram of the aluminum chloride solution of the same pH and concentration according to the present invention; Figure 11 This is a schematic diagram of the sterile PBS and bacterial suspension of the present invention; Figure 12This is a schematic diagram of the product and bacterial suspension of the present invention. Detailed Implementation

[0013] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0014] like Figure 1-12 As shown, this embodiment of the invention provides a targeted antiperspirant, which specifically includes the following steps: 1. Experimental Procedure 1. Preparation of chelating protectants Dissolve 0.1g of disodium EDTA in 10ml of water by stirring. Then dissolve 0.8g of triethyl citrate. Finally, add 5g of dipropylene glycol and stir at 60℃ for 10 minutes until transparent to form a chelating protective agent. 2. Preparation of Activated Solution for Aluminum Hydroxide Chloride Add 8g of aluminum hydroxychloride to the first step chelation protection solution and stir at 5000rpm. Add 4 ml of saturated sodium bicarbonate solution to adjust the pH to 6. 3. Formation of blank micelles 3g poloxamer 407 + 57g deionized emulsion → refrigerate at 4℃ and stir for 2 hours until the emulsion becomes transparent → form blank micelles (particle size 20nm). 4. Micelles loaded with aluminum hydroxychloride Heat the blank micelle solution to 15°C, then slowly add the ACH activation solution and stir at 300 rpm. Heating to 37℃ at a rate of 1℃ / min → poloxamer hydrophobic chain shrinkage encapsulation of Al³⁺ Keep warm and stir for 30 minutes → Al³⁺ is locked into the micelle core. 5. Cooling, curing, and post-treatment Cool down to 25℃ → micelle structure solidifies Add 1.5g trehalose and 10g dipropylene glycol → stir to dissolve → obtain a pale blue opalescent dispersion. Adding to the formula Mix 2g of inulin with 88.595ml of deionized water at 75℃ until homogeneous. Separately, heat and melt 0.2g of bisabolol, 0.3g of peppermint oil, 0.005g of rose essence, 1.2g of phenoxyethanol, 0.7g of hexylhexylglycerin, and 2g of emulsifier WR-H07 (glyceryl stearate / cetearyl oleate / cetyl phosphate potassium). Add this mixture to the inulin-water mixture, maintain the temperature, stir at 300rpm for 3 minutes, then at 12000rpm → homogenize for 5 minutes and let stand at room temperature. Add 8ml of pale blue opalescent dispersion, and finally mix at 200rpm until homogeneous. Figure 1 Final emulsion and Figure 2 The light blue opalescent dispersion is shown.

[0015] Part Two: Antiperspirant Efficacy Test 2.1 Materials and Reagents 2.1.1 Materials: Qualitative filter paper with a diameter of 9cm; petri dishes; 10-100uL pipettes; electronic balance; electric drying oven; 30cm ruler 2.1.2 Reagents: Urea; lactic acid; sodium chloride; sodium hydroxide; methylene blue. Water was Wahaha purified water. 2.2 Filter paper diffusion experiment To simulate the antiperspirant mechanism of aluminum chloride gelling with sweat on the skin surface and thus blocking sweat gland ducts, the antiperspirant was compared with pure water and aluminum chloride emulsion of the same concentration. The diffusion time and filter paper penetration time of artificially simulated sweat were observed under the action of pure water (negative control), aluminum chloride of the same concentration and the antiperspirant (positive control) to directly compare the antiperspirant effect.

[0016] 2.2.1 Filter paper diffusion experiment method Step 1: Sample pretreatment (film formation) Filter paper: Take three dry filter papers, and use a pipette to accurately draw the same volume of pure water, 8% aluminum chloride emulsion, and 100 μL of test sample, respectively. Add them drop by drop evenly to the center area of ​​the filter paper, allowing the liquid to spread naturally to form a moist circular spot. Then place the coated filter paper horizontally in a dust-free place and put it in a 40°C oven to accelerate drying (about 1 hour).

[0017] Principle: This step simulates the process of antiperspirant drying under the armpit, where the active ingredients dehydrate to form an insoluble gel / film.

[0018] Step 2: Prepare artificial sweat: Add 0.5% NaCl, 0.1% urea, and 0.01% lactic acid to 20ml of deionized water, adjust the pH to 5.5 with sodium hydroxide, and add a small amount of methylene blue powder to the prepared artificial sweat for staining (to facilitate observation and recording of the diffusion process).

[0019] Step 3: Place the dried filter paper from Step 1 flat in three petri dishes, and place another layer of filter paper under each film-forming filter paper. Use a pipette to draw 50 μL of artificial sweat and drop it vertically and slowly onto the center of the previously coated sample. Press the timer to observe the diffusion of the colored sweat on the filter paper.

[0020] Step 4: Data Recording and Evaluation Longitudinal diffusion: The longer the penetration time (T), the more effective the "barrier layer" formed by the antiperspirant.

[0021] Indicator: The time required from the moment sweat is added until the first drop of sweat completely penetrates the filter paper and drips off, or until a noticeable wet spot first appears at the center of the back of the filter paper.

[0022] Lateral diffusion: In the same amount of time, the smaller the diffusion diameter (D), the better the antiperspirant effect.

[0023] Indicators: After adding sweat, measure the total diffusion diameter and the diameter of the colored area formed on the filter paper with a ruler every 30 seconds.

[0024] Repeated experiments: Each sample was repeated 4 times in parallel, and the average value and standard deviation were taken to eliminate random errors.

[0025] Experimental data: 2.3. Summary of Penetration Time Data: Sample number describe Experiment 1(s) Experiment 2(s) Experiment 3(s) Experiment 4(s) Average value (s) Standard deviation (s) 1 Deionized water 8 6 5 6 6.25 1.26 2 4% aluminum chloride emulsion 38 47 52 46 45.75 5.91 3 Product Emulsion 107 128 112 117 116 9.5 2.4. Summary of diffusion diameter data: 2.4.1 Deionized water time Experiment 1 (mm) Experiment 2 (mm) Experiment 3 (mm) Experiment 4 (mm) Average value (mm) Standard deviation (mm) 30 24（15） 26（15） 25（14） 25（15） 25（14.8） 0.8（0.5） 60 27（16.5） 30（17） 27（17） 27（17） 27.8（16.9） 1.5（0.3） 90 30（17） 32（17） 28（18） 29（18.5） 29.8（17.6） 1.7（0.7） 120 31（17.5） 32（17.5） 30（18.5） 30（19） 30.8（18.1） 0.9（0.7） 150 31（17.5） 32（17.5） 30（18.5） 30（19） 30.8（18.1） 1.0（0.8） 2.4.24% aluminum hydroxychloride solution time Experiment 1 (mm) Experiment 2 (mm) Experiment 3 (mm) Experiment 4 (mm) Average value (mm) Standard deviation (mm) 30 19（8） 19（8） 20（11） 20（12） 19.5（9.8） 0.6（2.1） 60 25（11） 23（12） 23（14） 25（15） 24（13） 1.2（1.8） 90 26（13） 27（14） 26（15） 28（17.5） 26.8（14.9） 1.0（1.8） 120 27（15） 28（15） 29（16） 28.5（18） 28.1（16） 1.0（1.4） 150 29（16.5） 30（16） 31（16.5） 29（18.5） 29.8（16.9） 1.0（1.2） 180 29（16.5） 30（16） 31（16.5） 29（18.5） 29.5（17.1） 1.3（1.1） 2.4.3 Product: Antiperspirant Lotion time Experiment 1 (mm) Experiment 2 (mm) Experiment 3 (mm) Experiment 4 (mm) Average value (mm) Standard deviation (mm) 30 5（5） 6（6） 5（5） 6（6） 5.5（5.5） 0.6（0.6） 60 7（5.5） 6.5（6） 6（6） 7（7） 6.4（6.1） 0.5（0.6） 90 9.5（6） 7（7） 7.5（7） 9.5（7） 8.4（6.8） 1.3（0.5） 120 12（8） 10（8） 13（7.5） 14（7.5） 12.3（7.8） 1.5（0.3） 150 16（10） 14（8.5） 15（8） 16（8） 15.3（8.6） 0.9（0.9） 180 19（11） 19（9） 18（9） 19（9） 18.8（9.5） 0.5（1.0） 210 22.5（12） 23（10） 20.5（9.5） 20.5（10） 21.8（10.4） 1.4（1.1） 240 24（12） 25（10） 22.5（9.5） 21.5（10.5） 23.3（10.5） 1.3（1.1） 270 24（12） 25（10） 24（10） 23（11.5） 24（10.9） 0.8（0.9） 300 — 25（10） 24（10） 23（11.5） 23.7（10.5） 0.6（0.7） Note: The area outside the parentheses is the total diffusion diameter (mm), and the area outside the parentheses is the diameter of the colored area (mm).

[0026] 2.5. Data Statistical Analysis: index Deionized water 4% aluminum hydroxychloride Product Emulsion Mean Penetration Time 6.25s 45.75s 116s Penetration time growth factor Benchmark (1x) 7.32 times 18.56 times Final diffusion diameter 30.8mm 29.5mm 23.7mm diffusion completion time Approximately 150 seconds Approximately 180s Approximately 300 seconds Data stability high high high 2.5.1 Experiment Summary and Analysis Compared to deionized water and 4% aluminum chloride emulsion, the product emulsion exhibited significantly prolonged penetration time and lateral diffusion. The penetration time was twice that of the aluminum chloride solution at the same concentration, and it left almost no residue on the lower filter paper. Lateral diffusion required 300 seconds to reach a stable state, and the final diffusion diameter was the smallest, indicating that the product emulsion has the strongest diffusion resistance to sweat. Furthermore, the reaction area of ​​the product antiperspirant emulsion was consistently smaller than that of the control group, indicating a superior barrier effect. The standard deviation of the data from the four parallel experiments was less than 1.5, demonstrating good reproducibility. 2.6 Description of the attached figures like Figure 3 The samples and control group after drying at 40℃ are shown in the image. From left to right, they are deionized water, 4% aluminum chloride solution, and product emulsion. Figure 4 The diffusion results of artificial sweat after being dropped onto filter paper for 30 seconds, from left to right: deionized water, 4% aluminum chloride solution, and product emulsion; Figure 5 The diffusion results of artificial sweat after being dropped onto filter paper for 150 seconds are shown from left to right: deionized water, 4% aluminum chloride solution, and product emulsion. Figure 6 The final diffusion results of artificial sweat after it was dripped onto the filter paper are shown from left to right as follows: deionized water, 4% aluminum chloride solution, and product antiperspirant lotion. The corresponding result below is the penetration result of the second layer of filter paper (vertical diffusion result).

[0028] Three: Performance Testing 3.1 Properties: Milky white dilute emulsion. After standing for 30 days, no suspension or precipitate was observed (compared with aluminum chloride solution of the same concentration and pH value, aluminum chloride solution is a turbid dilute colloidal solution).

[0029] 3.2 pH value: The pH value of the product emulsion obtained by testing with a pH meter.

[0030] 3.3 Average particle size: The average particle size obtained by testing according to GB / T 19627-2005 standard.

[0031] 3.4 Zeta potential: The Zeta potential of the product emulsion obtained by using a Zeta potential analyzer. 3.5 Description of the attached figures Reference Figure 7 This is the undiluted particle size; reference Figure 8 It is the undiluted Zeta potential; Figure 9 It is an antiperspirant product; Figure 10 It is an aluminum chloride solution with the same pH and concentration. Figure 11 It consists of sterile PBS and bacterial suspension; Figure 12 Products and bacterial suspensions.

[0032] 3.5 Summary and Analysis Adjusting the pH to 6.28 ensures that this antiperspirant lotion is gentlest on the skin, closest to the skin's optimal pH, reducing irritation to sensitive skin. The lotion's particle size is 149.8 nm; compared to ordinary antiperspirants, this nano-sized lotion provides a larger surface area, which is beneficial for the dispersion and absorption of the active ingredient (aluminum hydroxyl chloride hydrolysate intermediate) on the skin. 4. Antibacterial ability test 4.1 Experimental Objective: In order to test the inhibitory ability of this technology product against harmful bacteria in actual use, a positive control group was set up to test the product's inhibitory ability against bacteria in sweat.

[0033] 4.2 Experimental Materials and Reagents 4.2.1 Materials: Human sweat, nutrient agar, antiperspirant product, phosphate buffer. 4.2.2 Reagents: Incubator, sterile Petri dishes, sterile test tubes, sterile pipette tips, sterile spreaders, sterile filters (0.22μm, for solution sterilization) 4.3 Experimental Design 4.3.1. Experimental group: Product + bacterial suspension → incubation for a certain period of time → viable bacteria count.

[0034] 4.3.2. Positive control group: sterile PBS + bacterial suspension → incubation time → viable cell count. (Represents the initial bacterial count N0).

[0035] 4.4 Experimental Methods 4.4.1 Take a sterile test tube, add 0.1 mL of experimental sweat (the subject's underarm sweat is collected with a cotton swab and placed in a test tube containing 5 mL of physiological saline), then add 0.9 mL of the test product (1:9 bacterial solution: product), mix well immediately and start timing at 25°C (room temperature). 4.4.2 Functions and neutralization: After 10 minutes, remove 0.1 mL of the mixture and immediately add it to 9.9 mL of PBS solution. Vortex to mix thoroughly and neutralize completely. 4.4.3 viable cell count: The neutralized solution is then serially diluted tenfold (usually diluted to...). , , ),according to , , Dilute the bacteria to three different dilutions, and use the spread plate method to inoculate 0.1 mL of each solution onto the corresponding agar plates. Prepare three replicates for each dilution. Incubate the bacteria at 36±1℃ for 48±2 hours. 4.4.4 Procedure for the positive control group: Replace the product with 0.9 mL PBS, and follow the same steps as the experimental group. The colony count in this group represents the initial bacterial load at "time 0".

[0038] 4.5 Counting and Summarizing: The number of colonies on the counting plate is calculated according to the colony counting rules to determine the number of surviving colonies in the experimental bacterial solution or product-sweat mixture. The count is shown in the table below. 4.6 Summary and Analysis The results are shown in the table above. It is clear that compared with the plate containing no antiperspirant, the bacterial count in the mixture of product and sweat at four different dilution ratios was extremely low. This indicates that the antiperspirant has a strong inhibitory effect on harmful bacteria during actual use, and the inulin in the formula has a significant effect on reducing harmful bacteria in sweat.

[0039] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A method for preparing a targeted antiperspirant, characterized in that, Specifically, the following steps are included: (1) Preparation of chelating protectant: Dissolve 0.1 parts of disodium EDTA, 0.8 parts of triethyl citrate and 5 parts of dipropylene glycol in 10 parts of water by mass, and stir at 60°C to form a transparent solution; (2) Preparation of activated aluminum hydroxychloride solution: Add 8 parts of aluminum hydroxychloride to the solution obtained in step (1), and add saturated sodium bicarbonate solution under high speed to adjust the pH to 6.0; (3) Preparation of blank micelles: Dissolve 3 parts of poloxamer 407 in 57 parts of deionized water and refrigerate at 4°C while stirring until a transparent blank micelle solution is formed; (4) Micelle loading: The blank micelle solution obtained in step (3) is heated to 15°C, and the activation solution obtained in step (2) is added. The temperature is increased to 37°C at a rate of 1°C / min under stirring at 300 rpm, and kept warm and stirred for 30 minutes so that Al³⁺ is loaded into the hydrophobic core of the micelles. (5) Cooling and solidification: Cool the system obtained in step (4) to 25°C, add 1.5 parts of trehalose and 10 parts of dipropylene glycol, stir to dissolve, and obtain a micelle dispersion; (6) Emulsion preparation: Dissolve 2 parts of inulin in 88.595 parts of deionized water and mix well; separately, mix 0.2 parts of bisabolol, 0.3 parts of peppermint oil, 0.005 parts of rose fragrance, 1.2 parts of phenoxyethanol, 0.7 parts of hexylhexylglycerin and 2 parts of emulsifier WR-H07 by hot melting, add to the inulin aqueous solution, homogenize at high speed and cool to room temperature, and finally add 8 parts of the micelle dispersion obtained in step (5) and mix well to obtain the targeted antiperspirant.

2. The method for preparing a targeted antiperspirant according to claim 1, characterized in that: The targeted antiperspirant prepared by the method has a pH value of 6.0-6.

5.

3. The method for preparing a targeted antiperspirant according to claim 1, characterized in that: The average particle size of the nanomicelles of the active ingredient in the targeted antiperspirant prepared by the method is 20 nm to 150 nm.

4. The method for preparing a targeted antiperspirant according to claim 1, characterized in that: The targeted antiperspirant prepared by the method releases aluminum hydroxychloride nanogel clusters from the nanomicelles at skin temperature. The nanogel clusters crosslink to form a porous physical membrane under sweat pH>6.5 conditions, thereby reversibly blocking the sweat gland ducts.

5. The method for preparing a targeted antiperspirant according to claim 1, characterized in that: The inulin is used to regulate the skin's microbiome balance, and the bisabolol is used to soothe the skin and repair the skin barrier.

6. A method for evaluating the antiperspirant effect of a targeted antiperspirant according to any one of claims 1-5, characterized in that, Includes the following steps: (a) The antiperspirant is evenly coated onto filter paper and dried to form a film; (b) Artificial simulated sweat was dropped onto the film-forming area, and the time it took for the sweat to penetrate the filter paper and the lateral diffusion diameter were recorded. (c) The antiperspirant effect was evaluated by penetration time and diffusion diameter.

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