Anti-nasal obstruction essential oil composition and preparation method thereof

Abstract

The invention provides an anti-nasal obstruction essential oil composition and a preparation method thereof, and belongs to the technical field of compound essential oil. The essential oil composition comprises compound essential oil and an amphiphilic lactobacillus fermentation lysate composition, the compound essential oil is prepared from 1 to 15 parts of flos magnoliae essential oil, 1 to 10 parts of bay leaf essential oil, 1 to 8 parts of linalool thyme essential oil, 1 to 8 parts of holy bay essential oil and 1 to 5 parts of herba asari essential oil; the amphiphilic lactobacillus fermentation lysate composition is prepared from the following components in parts by weight: 50 to 80 parts of rosemary hydrolat, 1 to 7 parts of Montanov L and 1 to 10 parts of lactobacillus fermentation lysate; the mass ratio of the amphiphilic lactobacillus fermentation lysate composition is 92%-98%. The five essential oils are compounded in proportion to prepare the compound essential oil, and the amphiphilic lactobacillus fermentation lysate composition is added; wherein the compound essential oil is based on the compatibility theory of monarch, minister, assistant and guide, and has obvious effects of warming channels, resolving dampness, opening orifices and conditioning root causes, and the amphiphilic lactobacillus fermentation lysate composition is added, so that the compound essential oil is safer, milder and more comfortable, has the functions of quickly opening orifices and maintaining for a long time, is safe, mild and non-irritant, is scientific in compatibility, and is suitable for sensitive people such as children and old people to use.

Description

Technical Field

[0001] This invention belongs to the field of compound essential oil technology, and specifically relates to an anti-nasal congestion essential oil composition and its preparation method. Background Technology

[0002] Traditional Chinese medicine aromatherapy has a long history, with records of fumigation, moxibustion, and the brewing of fragrant wines dating back to the Shang Dynasty. It was an important adjunct therapy for respiratory diseases in ancient times, and herbal essential oils are widely used in this field. Besides being natural, safe, highly active, and effective, herbal essential oils are composed of small molecules, typically ranging from tens to hundreds of Daltons—approximately 1000 times smaller than human cells, belonging to the nanoscale. Their lipid-soluble and dual-mode properties allow them to pass through cell membranes, making them highly permeable. After transdermal application, they enter the bloodstream within seconds to minutes. Furthermore, herbal essential oils are metabolized extremely quickly, being eliminated from the body in just a few hours.

[0003] Nasal congestion is a common symptom that makes breathing difficult, especially in children, where it can disrupt sleep and, in severe cases, even affect intellectual development and overall physical health. Currently, products on the market for relieving nasal congestion mainly fall into the following categories: chemical drugs (such as ephedrine-containing nasal drops), which are fast-acting but long-term use can easily lead to drug-induced rhinitis; physical therapy products (such as saline nasal irrigation), which are safe but slow-acting; and common essential oil products, which are mostly single-ingredient (such as eucalyptus or peppermint) or simply compounded, lacking comprehensive efficacy and multiple synergistic effects such as anti-infection, mucosal repair, and immune regulation. Some products overuse ingredients like peppermint, camphor, or high concentrations of thymol, irritating the nasal mucosa of children and sensitive individuals. Furthermore, they lack a holistic view from Traditional Chinese Medicine, failing to consider the pathogenesis of nasal congestion as "Yang deficiency and cold stagnation, turbid evil obstructing the nasal passages," and lacking the compatibility design of warming Yang, resolving dampness, and guiding the medicine along the meridians.

[0004] Some existing technologies attempt to use traditional Chinese medicine essential oils for nasal congestion relief. For example, common Asarum essential oil, without safrole removal treatment, poses potential risks of hepatotoxicity and mucosal irritation. Furthermore, it lacks systematic guidance based on the principles of traditional Chinese medicine principles of compatibility, resulting in weak synergistic effects among its components. Moreover, these are mostly pure oils, with a greasy texture and slow absorption, making it difficult to simultaneously carry water-soluble active ingredients and achieve the synergistic delivery of both oil and water effects. Therefore, developing a nasal congestion relief product specifically for sensitive populations such as children and the elderly, offering both rapid nasal clearing and long-lasting nourishment, while being safe, gentle, and scientifically formulated, has become a pressing technical challenge in this field. Summary of the Invention

[0005] The purpose of this invention is to provide an anti-nasal congestion essential oil composition and its preparation method, aiming to solve at least one technical problem in the background art.

[0006] The object of this invention is achieved in the following manner: To better implement this research project, the present invention provides an anti-nasal congestion essential oil composition, the essential oil composition comprising a compound essential oil and an amphiphilic lactobacillus fermentation lysate composition; The compound essential oil contains the following essential oil components in parts by weight: Magnolia flower essential oil 1-15 parts; Bay leaf essential oil 1-10 parts; 1-8 parts of linalool thyme essential oil; Tonka essential oil 1-8 parts; Asarum essential oil 1-5 parts; The amphiphilic lactobacillus fermentation lysate composition comprises the following raw materials in parts by weight: 50-80 parts rosemary hydrosol; Montanov L 1-7 copies; 1-10 parts of Lactobacillus fermentation lysate; Among them, the Magnolia biondii essential oil was obtained from the dried flower buds of Magnolia biondii using supercritical CO2 extraction. Bay leaf essential oil is obtained from bay leaf leaves using a steam distillation extraction method. The linalool thyme essential oil was obtained by steam distillation extraction from the above-ground parts (stems, leaves, and flowers) of the entire thyme plant harvested at the early flowering stage. The essential oil of *Linglingxiang* was obtained from the whole herb, including roots, of *Linglingxiang* using critical CO2 extraction. Asarum essential oil was obtained from the rhizome of Asarum heterotropoides using supercritical CO2 extraction, followed by stepwise decompression removal of safrole to obtain the Asarum essential oil. The compound essential oil and the amphiphilic lactobacillus fermentation lysate composition are mixed evenly to obtain the essential oil composition.

[0007] Preferably, the compound essential oil comprises the following essential oil components in parts by weight: Magnolia flower essential oil, 10-15 parts; 5-10 parts bay leaf essential oil; 3-8 parts of tonka bean essential oil; 3-8 parts of linalool thyme essential oil; Asarum essential oil 2-4 parts; The amphiphilic lactobacillus fermentation lysate composition comprises the following raw materials in parts by weight: 70-80 parts rosemary hydrosol; Montanov L 5-6 portions; 2-5 portions of Lactobacillus fermentation lysate.

[0008] Preferably, in the compound essential oil, the weight ratio is: Magnolia biondii essential oil: Laurel leaf essential oil: Linalool thyme essential oil: Agastache rugosa essential oil: Asarum essential oil = (4~5):(3~4):(2~3):(2~3):(1~2); In the amphiphilic lactobacillus fermentation lysate composition, the weight ratio is: rosemary hydrosol: Montanov L: lactobacillus fermentation lysate = (35~40):(2~3):(1~3).

[0009] Preferably, the mass ratio of the amphiphilic lactobacillus fermentation lysate composition in the essential oil composition is 92% to 98%.

[0010] Preferably, in the compound essential oil, the ratio by weight is: Magnolia biondii essential oil: Laurel leaf essential oil: Linalool thyme essential oil: Tonka bean essential oil: Asarum essential oil = 5:4:3:3:1; In the amphiphilic lactobacillus fermentation lysate composition, the weight ratio of rosemary hydrosol: Montanov L: lactobacillus fermentation lysate is 37.5:2.5:2.

[0011] A second aspect of the present invention provides a method for preparing the above-mentioned anti-nasal congestion essential oil composition, comprising the following steps: The dried flower buds of the cleaned magnolia, the leaves of the laurel, the whole above-ground parts (stems, leaves and flowers) of the thyme plant picked at the beginning of flowering, the whole herb of the fragrant grass with roots, and the dried rhizomes of the asarum were crushed. Magnolia flower buds were processed and dried, then subjected to supercritical CO2 extraction to obtain Magnolia biondii essential oil. Bay leaf essential oil was obtained by steam distillation of the processed bay leaves. The above-ground parts (stems, leaves, and flowers) of the entire thyme plant, harvested at the early flowering stage after processing, were steam distilled to obtain linalool thyme essential oil. The processed whole herb of *Lingxiang* (with roots) was subjected to supercritical CO2 extraction to obtain Linglingxiang essential oil. The processed rhizomes of Asarum were subjected to supercritical CO2 extraction to obtain Asarum essential oil, followed by stepwise decompression to remove safrole to obtain Asarum essential oil. A compound essential oil is prepared by mixing magnolia flower essential oil, bay leaf essential oil, linalool thyme essential oil, tonka bean essential oil and asarum essential oil in a certain proportion; The compound essential oil is mixed evenly with the melted amphiphilic lactobacillus fermentation lysate composition to obtain the essential oil composition.

[0012] Preferably, the step of uniformly mixing the compound essential oil with the melted amphiphilic lactobacillus fermentation lysate composition to obtain the essential oil composition is as follows: Mix rosemary hydrosol and Montanov L in a container, heat to 70-75°C until completely melted, and stir with an electric stirrer for 2-3 minutes until Montanov L is completely dissolved and the liquid becomes clear; When the temperature drops to below 40°C, add the Lactobacillus fermentation lysate and stir until homogeneous to obtain the amphiphilic Lactobacillus fermentation lysate composition; Magnolia biondii oil, bay leaf oil, linalool thyme oil, tonka bean oil, and asarum oil were added to the amphiphilic lactobacillus fermentation lysate composition and stirred until well mixed.

[0013] Preferably, in preparing the Magnolia biondii essential oil, the supercritical CO2 extraction temperature is 35-50℃, the pressure is 15-25MPa, and the time is 60min~90min; In preparing the laurel leaf essential oil, the heating temperature in the steam distillation apparatus is 100℃~150℃, the pressure is 100mbar~300mbar, and the heating time is 2h~4h. In preparing the linalool thyme essential oil, the heating temperature in the steam distillation apparatus is 100℃~120℃, the pressure is 300mbar~500mbar, and the heating time is 2h~3h. In preparing the Linglingxiang essential oil, the supercritical extraction temperature was 35-45℃, the pressure was 20-30MPa, and the time was 90min-150min. In preparing the Asarum essential oil, the supercritical CO2 extraction temperature is 40-50℃, the pressure is 25-35MPa, and the time is 2-3h. Then, safrole is removed stepwise under reduced pressure. The pressure is adjusted to 12-15MPa and the temperature is 40-50°C. Some safrole is first precipitated and separated as waste. Then, the pressure is adjusted to 4-8MPa and the temperature is 30-40°C to remove the residual trace amount of safrole. The goal is to reduce its content to below 0.01%.

[0014] Magnolia biondii essential oil is a traditional Chinese herbal plant essential oil extracted from the dried flower buds of Magnolia biondii, Magnolia denudata, or Magnolia wudangensis using supercritical CO2 extraction. Its core active ingredients include 1,8-cineole, camphor, and α-terpineol. Its core effects are clearing nasal passages and constricting blood vessels in the nasal mucosa, making it an essential remedy for relieving nasal congestion. It also has anti-inflammatory and anti-allergic properties, reducing nasal discharge and improving nasal ventilation.

[0015] Bay leaf essential oil is a plant essential oil extracted from the leaves of the bay tree through steam distillation. Its main active ingredients are 1,8-cineole, eugenol, and eugenol acetate. Its core effects include strong anti-infection and nasal decongestion relief. It can effectively inhibit respiratory pathogens, relieve nasal congestion, and warm and unblock the meridians.

[0016] Linalool thyme essential oil is a plant essential oil extracted from the entire above-ground parts (stems, leaves, and flowers) of thyme harvested at the early flowering stage through steam distillation. Its main active ingredients are linalool and terpineol. Its core benefits include mild anti-infective properties, immune regulation, and mucus dissolving. It significantly relieves respiratory infections and nasal congestion, while also calming the mind and relieving fatigue. With a sweet and warm scent, it is suitable for children and those with sensitive skin.

[0017] Fuchsia essential oil (also known as lavender essential oil) is a traditional Chinese herbal plant essential oil extracted from the whole herb of *Lysimachia christinae*, a plant in the Primulaceae family, using supercritical CO2 extraction. Its main active ingredients are coumarins and flavonoids. Its core effects include dispelling foulness and turbidity, clearing the orifices and refreshing the mind. It can resolve dampness and turbidity, improve nasal congestion and headaches, and also has the functions of fixing fragrance and harmonizing various medicines.

[0018] Asarum essential oil is a traditional Chinese herbal essential oil obtained by extracting the rhizome of Asarum heterotropoides (a plant in the Aristolochiaceae family) using supercritical CO2 extraction followed by stepwise vacuum distillation to remove safrole. Its main active ingredients are methyl eugenol and elemol, which dilate blood vessels, increase blood flow, enhance oxygen and nutrient supply, and improve microcirculation. Due to its unique aroma and antibacterial properties, it is often used to improve respiratory problems, relieve symptoms such as nasal congestion, sore throat, and cough, reduce mucus secretion, and promote respiratory relaxation. It is worth noting that ordinary Asarum essential oil contains safrole, making it contraindicated for pregnant women and infants. Therefore, we fractionally distill to remove safrole, making it safer.

[0019] Compared with the prior art, the present invention has the following superior effects:

[0020] The aforementioned anti-nasal congestion essential oil composition uses compound essential oils based on the "principal, assistant, adjuvant, and guide" formulation theory. Magnolia flower essential oil is the principal ingredient for clearing nasal passages; bay leaf essential oil and linalool thyme essential oil are the assistant ingredients to warm the meridians and clear the passages; tonka bean essential oil is the adjuvant ingredient to dispel foulness and turbidity and harmonize the other ingredients; and asarum essential oil is the guiding ingredient to penetrate deeper into the body. Specifically, magnolia flower and bay leaf essential oils quickly clear the passages and treat the symptoms; asarum and tonka bean essential oils warm and dispel cold and dampness, dispel foulness and turbidity, and treat the root cause; and linalool thyme essential oil regulates immunity. The five ingredients work synergistically to have a significant effect of warming the meridians, dispelling dampness, clearing the passages, and addressing the root cause to reduce recurrence. It is an anti-nasal congestion product that combines rapid nasal clearing with long-lasting maintenance, is safe and gentle, and has a scientifically formulated composition, making it particularly suitable for sensitive groups such as children and the elderly.

[0021] The dosage of each single essential oil in the compound essential oil is precisely controlled. In particular, the dosage of Asarum essential oil is not only precisely controlled, but safrole is also fractionated out, and mild linalool thyme is selected to replace the strong peppermint or thymol-type thyme, which greatly reduces the irritation to the nasal mucosa, making it safer, milder, and less irritating, suitable for a wider range of people.

[0022] The addition of tonka bean in compound essential oils not only has the effect of dispelling foulness and turbidity, but also acts as a binder for aroma. Its unique hay-like aroma blends the mild herbal scent of magnolia essential oil with the spicy aroma of bay leaf essential oil, forming an overall warm and pleasant fragrance that significantly improves user acceptance.

[0023] The layered transparent system constructed from the amphiphilic lactobacillus fermentation lysate composition can stably carry both the oil phase compound essential oil and the aqueous phase active ingredients. While clearing the nasal passages, it repairs the damaged skin microecological barrier around the nose. Blending the compound essential oil with the amphiphilic lactobacillus fermentation lysate composition can delay the release rate of the active ingredients in the essential oil, making the dosage form advanced and improving its comfort and compliance.

[0024] The aforementioned anti-nasal congestion essential oil combination employs an optimal preparation method to improve the quality of individual essential oils and increase the yield of essential oils. Furthermore, a low-temperature stepwise addition method is used during the preparation of the essential oil combination to ensure that heat-sensitive active ingredients (Lactobacillus fermentation lysate and tonka bean essential oil) are not destroyed, thus preserving their biological activity to the greatest extent possible. Detailed Implementation

[0025] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention.

[0026] This invention provides an anti-nasal congestion essential oil composition comprising a compound essential oil and an amphiphilic lactobacillus fermentation lysate composition.

[0027] Specifically, the compound essential oil contains the following essential oil components in parts by weight: 1-15 parts Magnolia biondii essential oil; 1-10 parts Bay laurel leaf essential oil; 1-8 parts Linalool thyme essential oil; 1-8 parts Tonka balsam essential oil; 1-5 parts Asarum essential oil; Preferably, the following ingredients are used: 10-15 parts Magnolia biondii essential oil; 5-10 parts Bay laurel leaf essential oil; 3-8 parts Tonka bean essential oil; 3-8 parts Linalool thyme essential oil; and 2-4 parts Asarum essential oil. In the compound essential oil, the weight ratio of Magnolia biondii essential oil: Laurel leaf essential oil: Linalool thyme essential oil: Tonka bean essential oil: Asarum essential oil = (4~5):(3~4):(2~3):(2~3):(1~2), preferably 5:4:3:3:1.

[0028] Specifically, the amphiphilic lactobacillus fermentation lysate composition comprises the following raw materials in parts by weight: 70-80 parts rosemary hydrosol; 5-6 parts Montanov L; and 2-5 parts lactobacillus fermentation lysate. Preferably, the ingredients are: 70-80 parts rosemary hydrosol; 5-6 parts Montanov L; and 2-5 parts Lactobacillus fermentation lysate. According to the weight ratio, the ratio of rosemary hydrosol: Montanov L: Lactobacillus fermentation lysate is (35~40):(2~3):(1~3), preferably 37.5:2.5:2.

[0029] Specifically, the mass ratio of the amphiphilic lactobacillus fermentation lysate composition in the essential oil composition is 92% to 98%.

[0030] The dried flower buds of Magnolia were extracted using supercritical CO2 extraction, the essential oil of Laurel leaf was extracted using steam distillation, the entire above-ground parts (stems, leaves, and flowers) of Thyme harvested at the early flowering stage were extracted using steam distillation, the whole herb of Agrimonia pilosa with roots was extracted using supercritical CO2 extraction, and the rhizome of Asarum heterotropoides was extracted using supercritical CO2 extraction followed by stepwise depressurization to remove safrole, thereby obtaining the essential oils of Magnolia biondii, Laurel leaf, Linalool, Thyme, and Asarum heterotropoides.

[0031] Mix rosemary hydrosol and Montanov L in a container, heat to 70-75°C until completely melted, and stir with an electric stirrer for 2-3 minutes until Montanov L is completely dissolved and the liquid becomes clear; When the temperature drops below 40°C, add the Lactobacillus fermentation lysate and stir until homogeneous to obtain an amphiphilic Lactobacillus fermentation lysate composition.

[0032] Magnolia biondii oil, bay leaf oil, linalool thyme oil, tonka bean oil, and asarum oil were added to the amphiphilic lactobacillus fermentation lysate composition at low temperature and stirred until well mixed. Example 1

[0033] An anti-nasal congestion essential oil composition comprising a compound essential oil and an amphiphilic lactobacillus fermentation lysate composition.

[0034] By weight, the compound essential oils include: 10 parts Magnolia biondii essential oil; 5 parts Laurel leaf essential oil; 3 parts Tonka balsamina essential oil; 3 parts Linalool thyme essential oil; and 1 part Asarum essential oil.

[0035] The amphiphilic lactobacillus fermentation lysate composition, by weight, comprises: 70 parts rosemary hydrosol; 5 parts Montanov L; and 2 parts lactobacillus fermentation lysate.

[0036] Specifically, the mass ratio of the amphiphilic lactobacillus fermentation lysate composition in the essential oil composition is 92%.

[0037] The preparation method is as follows: (1) The dried flower buds of cleaned magnolia, the leaves of laurel, the whole plant of thyme (stems, leaves and flowers) harvested at the beginning of flowering, the whole plant of thyme with roots and the dried rhizomes of Asarum were crushed. The dried flower buds of the magnolia were extracted by supercritical CO2 to obtain magnolia essential oil. The leaves of laurel were steam distilled to obtain laurel leaf essential oil. The whole plant of thyme (stems, leaves and flowers) harvested at the beginning of flowering was steam distilled to obtain linalool thyme essential oil. The whole plant of thyme with roots was extracted by supercritical CO2 to obtain tonka bean essential oil. The rhizomes of Asarum were extracted by supercritical CO2 to obtain Asarum essential oil and then the safrole was removed by step-by-step decompression to obtain Asarum essential oil. Then, the magnolia essential oil, laurel leaf essential oil, linalool thyme essential oil, tonka bean essential oil and Asarum essential oil were mixed in proportion to obtain compound essential oil. (2) Mix rosemary hydrosol and Montanov L in a container, heat to 70-75℃ to completely melt them, stir with an electric stirrer for 2-3 minutes until Montanov L is completely dissolved and the liquid becomes transparent. When the temperature drops to below 40℃, add the Lactobacillus fermentation lysate and stir evenly to obtain the amphiphilic Lactobacillus fermentation lysate composition; (3) Add compound essential oil to the mixture of fermentation lysate of amphiphilic lactobacillus at low temperature and stir to mix evenly. Example 2

[0038] An anti-nasal congestion essential oil composition comprising a compound essential oil and an amphiphilic lactobacillus fermentation lysate composition.

[0039] By weight, the compound essential oils include: 11 parts Magnolia biondii essential oil; 6 parts Laurel leaf essential oil; 5 parts Tonka balsamina essential oil; 4 parts Linalool thyme essential oil; and 2 parts Asarum essential oil.

[0040] The amphiphilic lactobacillus fermentation lysate composition, by weight, comprises: 72 parts rosemary hydrosol; 5 parts Montanov L; and 3 parts lactobacillus fermentation lysate.

[0041] Specifically, the mass ratio of the amphiphilic lactobacillus fermentation lysate composition in the essential oil composition is 93%.

[0042] The preparation method is the same as in Example 1. Example 3

[0043] An anti-nasal congestion essential oil composition comprising a compound essential oil and an amphiphilic lactobacillus fermentation lysate composition.

[0044] By weight, the compound essential oils include: 12 parts Magnolia biondii essential oil; 8 parts Laurel leaf essential oil; 6 parts Tonka bean essential oil; 6 parts Linalool thyme essential oil; and 1 part Asarum essential oil.

[0045] The amphiphilic lactobacillus fermentation lysate composition, by weight, comprises: 74 parts rosemary hydrosol; 5.5 parts Montanov L; and 4 parts lactobacillus fermentation lysate.

[0046] Specifically, the mass ratio of the amphiphilic lactobacillus fermentation lysate composition in the essential oil composition is 94%.

[0047] The preparation method is the same as in Example 1. Example 4

[0048] An anti-nasal congestion essential oil composition comprising a compound essential oil and an amphiphilic lactobacillus fermentation lysate composition.

[0049] By weight, the compound essential oils include: 13 parts Magnolia biondii essential oil; 10 parts Laurel leaf essential oil; 7 parts Tonka bean essential oil; 8 parts Linalool thyme essential oil; and 2 parts Asarum essential oil.

[0050] The amphiphilic lactobacillus fermentation lysate composition, by weight, comprises: 76 parts rosemary hydrosol; 6 parts Montanov L; and 5 parts lactobacillus fermentation lysate.

[0051] Specifically, the mass ratio of the amphiphilic lactobacillus fermentation lysate composition in the essential oil composition is 95%.

[0052] The preparation method is the same as in Example 1. Example 5

[0053] An anti-nasal congestion essential oil composition comprising a compound essential oil and an amphiphilic lactobacillus fermentation lysate composition.

[0054] By weight, the compound essential oils include: 14 parts Magnolia biondii essential oil; 11 parts Laurel leaf essential oil; 8 parts Tonka balsamina essential oil; 8 parts Linalool thyme essential oil; and 3 parts Asarum essential oil.

[0055] The amphiphilic lactobacillus fermentation lysate composition, by weight, comprises: 75 parts rosemary hydrosol; 5.5 parts Montanov L; and 4 parts lactobacillus fermentation lysate.

[0056] Specifically, the mass ratio of the amphiphilic lactobacillus fermentation lysate composition in the essential oil composition is 95.5%.

[0057] The preparation method is the same as in Example 1. Example 6

[0058] An anti-nasal congestion essential oil composition comprising a compound essential oil and an amphiphilic lactobacillus fermentation lysate composition.

[0059] By weight, the compound essential oils include: 15 parts Magnolia biondii essential oil; 12 parts Laurel leaf essential oil; 9 parts Tonka balsamina essential oil; 9 parts Linalool thyme essential oil; and 3 parts Asarum essential oil.

[0060] The amphiphilic lactobacillus fermentation lysate composition, by weight, comprises: 75 parts rosemary hydrosol; 5 parts Montanov L; and 4 parts lactobacillus fermentation lysate.

[0061] Specifically, the mass ratio of the amphiphilic lactobacillus fermentation lysate composition in the essential oil composition is 95.5%.

[0062] The preparation method is the same as in Example 1.

[0063] Experimental Methods: Sixty patients with nasal congestion due to various causes (mainly manifested as nasal congestion and difficulty breathing) were randomly divided into three groups. The experimental group used the compound essential oil composition prepared in Example 6 of this invention, applied to both sides of the nose twice daily; control group 1 used a single essential oil diluted with jojoba oil (Magnolia biondii essential oil concentration was the same as the experimental group), and control group 2 used a single blank amphiphilic lactobacillus fermentation lysate composition. All treatments were conducted continuously for 7 days, and the time for nasal congestion relief and symptom improvement were recorded.

[0064] Results: In the experimental group, nasal congestion was significantly relieved within 5-10 minutes after use. After 3 days of continuous use, symptoms such as nasal congestion and difficulty breathing were significantly improved, with an effectiveness rate of 90%. In control group 1, nasal congestion improved within 10-20 minutes after use, but redness and itching occurred in the nasal ala area. After 3 days of continuous use, symptoms such as nasal congestion and difficulty breathing improved, with an effectiveness rate of 30%. In control group 3, nasal congestion was not relieved after use. After 3 days of continuous use, symptoms such as nasal congestion and difficulty breathing did not improve, with an effectiveness rate of 0%. No skin irritation or allergic reactions occurred in the experimental group.

[0065] In summary, this research project has produced actual samples and undergone multiple usage tests, demonstrating good efficacy and strong practicality. The raw materials are readily available, the preparation process is simple, and it is suitable for industrial production. The product is designed for sensitive groups such as children and the elderly, featuring ease of use, rapid nasal clearing and long-lasting care, safety, gentleness, and scientific formulation. It can be widely used in the daily care and adjunctive treatment of nasal congestion and has high market promotion value. The above-described embodiments only illustrate several implementation methods of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these all fall within the protection scope of the present invention. Therefore, the protection scope of this patent should be determined by the appended claims.

Claims

1. An anti-nasal congestion essential oil composition, characterized in that, The essential oil composition comprises a compound essential oil and a composition of amphiphilic lactobacillus fermentation lysate; The compound essential oil contains the following essential oil components in parts by weight: Magnolia flower essential oil 1-15 parts; Bay leaf essential oil 1-10 parts; 1-8 parts of linalool thyme essential oil; Tonka essential oil 1-8 parts; Asarum essential oil 1-5 parts; The amphiphilic lactobacillus fermentation lysate composition comprises the following raw materials in parts by weight: 50-80 parts rosemary hydrosol; Montanov L 1-7 copies; 1-10 parts of Lactobacillus fermentation lysate; The compound essential oil and the amphiphilic lactobacillus fermentation lysate composition are mixed evenly to obtain the essential oil composition.

2. The anti-nasal congestion essential oil composition according to claim 1, characterized in that, The compound essential oil contains the following essential oil components in parts by weight: Magnolia flower essential oil, 10-15 parts; 5-10 parts bay leaf essential oil; 3-8 parts of tonka bean essential oil; 3-8 parts of linalool thyme essential oil; Asarum essential oil 2-4 parts; The amphiphilic lactobacillus fermentation lysate composition comprises the following raw materials in parts by weight: 70-80 parts rosemary hydrosol; Montanov L 5-6 portions; 2-5 portions of Lactobacillus fermentation lysate.

3. The anti-nasal congestion essential oil composition according to claim 1, characterized in that, In the compound essential oil, the weight ratio is as follows: Magnolia biondii essential oil: Laurel leaf essential oil: Linalool thyme essential oil: Agastache rugosa essential oil: Asarum essential oil = (4~5):(3~4):(2~3):(2~3):(1~5); In the amphiphilic lactobacillus fermentation lysate composition, the weight ratio is: rosemary hydrosol: Montanov L: lactobacillus fermentation lysate = (35~40):(2~3):(1~3).

4. The anti-nasal congestion essential oil composition according to claim 3, characterized in that, In the compound essential oil, the weight ratio is as follows: Magnolia biondii essential oil: Laurel leaf essential oil: Linalool thyme essential oil: Agastache rugosa essential oil: Asarum essential oil = 5:4:3:3:1; In the amphiphilic lactobacillus fermentation lysate composition, the weight ratio of rosemary hydrosol: Montanov L: lactobacillus fermentation lysate is 37.5:2.5:

2.

5. The anti-nasal congestion essential oil composition according to claim 1, characterized in that, In the essential oil composition, the mass ratio of the amphiphilic lactobacillus fermentation lysate composition is 92%~98%.

6. The anti-nasal congestion essential oil composition and its preparation method according to claims 1 to 4, characterized in that, The preparation method includes the following steps: (1) The cleaned dried magnolia buds, laurel leaves, the whole above-ground parts (stems, leaves, and flowers) of thyme harvested at the early flowering stage, the whole herb of angelica with roots, and the dried rhizomes of asarum were crushed. Magnolia flower buds were processed and dried buds were extracted using supercritical CO2 extraction to obtain Magnolia biondii essential oil. Bay leaf essential oil was obtained by steam distillation of the processed bay leaves. The above-ground parts (stems, leaves, and flowers) of the entire thyme plant, harvested at the early flowering stage after processing, were steam distilled to obtain linalool thyme essential oil. The processed whole herb of *Lingxiang* (with roots) was subjected to supercritical CO2 extraction to obtain *Lingxiang* essential oil. The processed rhizome of Asarum heterotropoides was subjected to supercritical CO2 extraction to extract Asarum essential oil, followed by stepwise decompression to remove safrole, thus obtaining Asarum essential oil. Then, magnolia flower essential oil, bay leaf essential oil, linalool thyme essential oil, tonka bean essential oil and asarum essential oil are mixed in a certain proportion to obtain a compound essential oil; (2) The compound essential oil is mixed evenly with the melted amphiphilic lactobacillus fermentation lysate composition to obtain the essential oil composition.

7. The anti-nasal congestion essential oil composition and its preparation method according to claim 6, characterized in that, The steps for obtaining the essential oil composition by uniformly mixing the compound essential oil with the melted amphiphilic lactobacillus fermentation lysate composition are as follows: (1) Mix rosemary hydrosol and Montanov L in a container, heat to 70-75°C to completely melt it, stir with an electric stirrer for 2-3 minutes until Montanov L is completely dissolved and the liquid becomes transparent. When the temperature drops to below 40°C, add lactobacillus fermentation lysate and stir evenly to obtain an amphiphilic lactobacillus fermentation lysate composition. (2) Add magnolia oil, bay leaf oil, linalool thyme oil, tonka bean oil and asarum oil to the amphiphilic lactobacillus fermentation lysate composition and stir to mix evenly.

8. The anti-nasal congestion essential oil composition and its preparation method according to claim 6, characterized in that, In preparing the Asarum essential oil, the supercritical CO2 extraction temperature is 40-50°C, the pressure is 30-35 MPa, and the time is 2-3 hours. Then, safrole is removed stepwise under reduced pressure. The pressure is adjusted to 12-15 MPa and the temperature is 40-50°C. Some safrole is first precipitated and separated as waste. The pressure is adjusted to 4-8 MPa and the temperature is 30-40°C to remove the residual trace amount of safrole. The goal is to reduce its content to below 0.01%.

9. The anti-nasal congestion essential oil composition according to claim 1, characterized in that, The compound essential oil is based on the theory of "principal, assistant, adjuvant and guide". Magnolia flower essential oil is the principal medicine to open the nasal passages, laurel leaf essential oil and linalool thyme essential oil are the assistant medicines to help warm the meridians and open the nasal passages, tonka bean essential oil is the adjuvant medicine to dispel foulness and turbidity and harmonize the medicines, and asarum essential oil is the guide medicine to enter the interior through the meridians. Specifically, magnolia flower essential oil and bay leaf essential oil can quickly clear the orifices and treat the symptoms; asarum essential oil and tonka bean essential oil can warm and dispel cold and dampness, dispel foulness and turbidity and treat the root cause; linalool thyme essential oil regulates immunity. The five work together to have a significant effect of warming the meridians, dispelling dampness and clearing the orifices, conditioning the root cause and reducing recurrence.