Flavored turtle and deer paste and application thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and discloses flavored turtle and deer cream and application thereof. The flavored tortoise-deer paste is prepared from the following components in parts by weight: 8-12 parts of wine-processed rhizoma polygonati, 8-12 parts of fructus lycii, 4-6 parts of prepared tortoise plastron, 4-6 parts of flos carthami, 8-12 parts of radix codonopsis, 8-12 parts of semen cuscutae, 8-12 parts of radix hedysari, 8-12 parts of colla corii asini, 8-12 parts of deer-horn glue and 8-12 parts of radix cyathulae. According to the flavored tortoise-deer cream disclosed by the invention, through the synergistic effect of animal nourishing good medicines and plant qi-tonifying and blood-activating medicinal materials, the organic combination of replenishing essence and marrow, tonifying qi and nourishing blood as well as activating blood and dredging collaterals is realized, and the preparation is remarkable in efficacy, high in bioavailability and suitable for improving related clinical symptoms.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a flavored turtle and deer paste and its application. Background Technology

[0002] Osteoporosis is a systemic skeletal disease characterized by decreased bone strength and increased risk of fractures. Its main pathological features are reduced bone mass and deterioration of bone microstructure. Osteoporosis is often called a "silent disease" because it often has no obvious symptoms in its early stages. However, as the disease progresses, it can lead to back pain, decreased height, kyphosis, and the most serious consequence is fragility fractures (such as hip fractures and vertebral compression fractures), which can cause severe disability, significantly reduce the quality of life of older adults, and increase mortality. Western medicine's prevention and treatment strategies mainly include calcium and vitamin D supplementation, as well as the use of drugs that inhibit bone resorption or promote bone formation (such as bisphosphonates and selective estrogen receptor modulators), aiming to slow bone loss and reduce fracture risk.

[0003] In Traditional Chinese Medicine (TCM) theory, osteoporosis is often categorized under "bone weakness," "bone pain," or "kidney deficiency." The core pathogenesis in TCM lies in the deficiency of kidney essence. The kidney governs bones and produces marrow; insufficient kidney essence leads to malnourishment of the bones, resulting in skeletal fragility. Furthermore, spleen dysfunction (insufficient production of qi and blood) and qi stagnation and blood stasis are also important pathogenic factors. Currently, TCM plays a crucial auxiliary and regulatory role in the treatment of osteoporosis. Clinically, based on the principles of syndrome differentiation and treatment, methods such as tonifying the kidney and replenishing essence, strengthening the spleen and replenishing qi, and promoting blood circulation are employed. These methods include oral herbal medicine, acupuncture, and massage to regulate the balance of qi and blood throughout the body. Studies have shown that TCM can effectively relieve bone pain, improve back function, and increase bone density, and may have a synergistic effect and reduce toxicity when used in combination with Western medicine. Therefore, TCM provides a safe and individualized collaborative management plan for osteoporosis for patients who are unsuitable for or intolerant of Western medicine treatment, as well as those who require long-term conditioning to improve their constitution. Summary of the Invention

[0004] The purpose of this invention is to overcome the shortcomings of the aforementioned background technology, meet people's needs, and provide a flavored tortoise and deer antler paste and its applications. The flavored tortoise and deer antler paste of this invention uses a formula of "tortoise and deer antler to invigorate the Du meridian and replenish marrow as the principal ingredient, and spleen and kidney qi and blood to harmonize as the assistant ingredient," directly targeting the core pathogenesis of "kidney essence deficiency and malnourishment of bones and collaterals." The mechanism is as follows: Nourishing essence and replenishing marrow: With deer antler glue (10g to warm and unblock the Du meridian) and prepared tortoise shell (5g to subdue yang and nourish yin) as the core of "blood and flesh with affection", it works together with donkey-hide gelatin (10g) and wine-processed polygonatum to improve the efficiency of bone collagen synthesis, and repairs bone microstructure more precisely than calcium supplements alone. Spleen and Kidney Synergy: Astragalus membranaceus and Codonopsis pilosula (10g each) strengthen the Qi transformation of the middle Jiao, efficiently converting the essence of food and water into raw materials for kidney essence, thus overcoming obstacles to nutrient absorption; Invigorating blood circulation and relieving pain: Achyranthes bidentata (10g) guides the medicine into the collaterals to activate osteoblasts, while safflower (5g) slightly clears stagnation in the Du meridian, significantly improving bone pain and mobility.

[0005] Compared to bisphosphonates, its herbal paste formulation provides continuous bone nutrition delivery, avoiding the risks of reflux esophagitis and osteonecrosis of the jaw. Compared to conventional kidney-tonifying Chinese medicine, it is designed with a dual yin-yang tonifying approach using Cuscuta chinensis and Lycium barbarum (10g each), providing patients with an integrated solution of "strengthening bones, relieving pain, and preventing fractures" for both postmenopausal (estrogen deficiency) and age-related (growth hormone decline) osteoporosis.

[0006] To achieve the purpose of this invention, the flavored tortoise and deer paste of this invention contains preparation A and preparation B, as well as donkey-hide gelatin and deer antler gelatin. Preparation A contains Polygonatum sibiricum, wolfberry, prepared tortoise shell and safflower. Preparation B contains Codonopsis pilosula, Cuscuta chinensis, Achyranthes bidentata and Astragalus membranaceus.

[0007] Furthermore, in some embodiments of the present invention, the flavored tortoise and deer paste contains, by weight, 8-12 parts of Polygonatum sibiricum, 8-12 parts of Lycium barbarum, 4-6 parts of processed tortoise shell, 4-6 parts of Carthamus tinctorius, 8-12 parts of Codonopsis pilosula, 8-12 parts of Cuscuta chinensis, 8-12 parts of Astragalus membranaceus, 8-12 parts of donkey-hide gelatin, 8-12 parts of deer antler gelatin, and 8-12 parts of Achyranthes bidentata.

[0008] Furthermore, in some embodiments of the present invention, the flavored tortoise and deer paste contains, by weight, 9-11 parts of Polygonatum sibiricum, 9-11 parts of Lycium barbarum, 4.5-5.5 parts of processed tortoise shell, 4.5-5.5 parts of safflower, 9-11 parts of Codonopsis pilosula, 9-11 parts of Cuscuta chinensis, 9-11 parts of Astragalus membranaceus, 9-11 parts of donkey-hide gelatin, 9-11 parts of deer antler gelatin, and 9-11 parts of Achyranthes bidentata.

[0009] Furthermore, in some embodiments of the present invention, the flavored tortoise and deer paste contains, by weight, 9.5-10.5 parts of Polygonatum sibiricum, 9.5-10.5 parts of Lycium barbarum, 4.8-5.2 parts of processed tortoise plastron, 4.8-5.2 parts of Carthamus tinctorius, 9.5-10.5 parts of Codonopsis pilosula, 9.5-10.5 parts of Cuscuta chinensis, 9.5-10.5 parts of Astragalus membranaceus, 9.5-10.5 parts of donkey-hide gelatin, 9.5-10.5 parts of deer antler gelatin, and 9.5-10.5 parts of Achyranthes bidentata.

[0010] Furthermore, in some embodiments of the present invention, the flavored turtle and deer paste contains, by weight, 10 parts of Polygonatum sibiricum, 10 parts of Lycium barbarum, 5 parts of processed tortoise shell, 5 parts of safflower, 10 parts of Codonopsis pilosula, 10 parts of Cuscuta chinensis, 10 parts of Astragalus membranaceus, 10 parts of donkey-hide gelatin, 10 parts of deer antler gelatin, and 10 parts of Achyranthes bidentata.

[0011] In another aspect, the present invention also provides a method for preparing the aforementioned flavored turtle and deer antler paste, the method comprising the following steps: decocting preparation A and preparation B together according to the required ingredient ratio, filtering the decoction and concentrating it into a thick paste, adding donkey-hide gelatin and deer antler gelatin to melt, simmering over low heat to thicken the paste, and storing after cooling.

[0012] Furthermore, in some embodiments of the present invention, the ratio of the drug solution before and after concentration to a thick paste is 1.5-2.5:1.

[0013] Furthermore, in some embodiments of the present invention, the ratio of the drug solution before and after concentration to a thick paste is 1.8-2.2:1.

[0014] Furthermore, in some embodiments of the present invention, the ratio of the drug solution before and after concentration to a thick paste is 2:1.

[0015] Furthermore, in some embodiments of the present invention, the storage is carried out at 1-5°C.

[0016] Furthermore, in some embodiments of the present invention, the storage is carried out at 2-3°C.

[0017] On the other hand, the present invention also provides an application of the aforementioned flavored turtle and deer paste, wherein the application is the use of the flavored turtle and deer paste in the preparation of a drug for treating osteoporosis.

[0018] Compared with the prior art, the advantages of the present invention are as follows: (1) The flavored turtle and deer ointment of the present invention achieves continuous bone nutrition delivery through ointment dosage form, avoids the risk of reflux esophagitis and osteonecrosis of the jaw, and provides patients with an integrated solution of "strengthening bones-relieving pain-preventing fractures" for two types of osteoporosis pathologies: postmenopausal (estrogen deficiency) and senile (growth hormone decline).

[0019] (2) The flavored turtle and deer paste of the present invention is a compound Chinese medicine preparation that tonifies the kidney and replenishes essence, invigorates qi and promotes blood circulation. It overcomes the defects of existing prescriptions for treating diseases caused by kidney essence deficiency and qi and blood deficiency, which have weak tonifying power and insufficient circulation.

[0020] (3) This invention achieves an organic combination of replenishing essence and marrow, replenishing qi and nourishing blood, and promoting blood circulation by combining the synergistic effect of animal-based tonics and plant-based qi-invigorating and blood-activating herbs. The preparation has significant efficacy, high bioavailability, and is suitable for improving related clinical symptoms. Detailed Implementation

[0021] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to embodiments. Additional aspects and advantages of this invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. It should be understood that the following description is merely illustrative and not intended to limit the invention.

[0022] The terms “comprising,” “including,” “having,” “containing,” or any other variations thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, step, method, article, or apparatus that includes the listed elements is not necessarily limited to those elements, but may include other elements not expressly listed or elements inherent to such composition, step, method, article, or apparatus.

[0023] The indefinite articles “a” and “an” preceding an element or component of this invention do not impose any limitation on the quantity (i.e., number of times) of the element or component. Therefore, “an” or “a” should be interpreted as including one or at least one, and the singular form of an element or component also includes the plural form, unless the quantity clearly refers only to the singular form.

[0024] Furthermore, the terms "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., described below refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms are not necessarily directed at the same embodiment or example. Moreover, the technical features involved in the various embodiments of the present invention can be combined with each other as long as they do not conflict with each other.

[0025] In a specific embodiment of the present invention, each dose of the flavored turtle and deer paste contains, by weight, 10g of Polygonatum sibiricum, 10g of Lycium barbarum, 5g of processed tortoise shell, 5g of safflower, 10g of Codonopsis pilosula, 10g of Cuscuta chinensis, 10g of Astragalus membranaceus, 10g of donkey-hide gelatin, 10g of deer antler gelatin, and 10g of Achyranthes bidentata.

[0026] The preparation method includes the following steps: According to the required ingredient ratio, decoct preparation A and preparation B together, filter the decoction and concentrate it to a thick paste (the ratio of the decoction before and after is 2:1), add donkey-hide gelatin and deer antler gelatin to melt, simmer over low heat to thicken the paste, cool and seal it, and store it at 2-3℃.

[0027] Other herbal paste products on the market have a slow onset of action, generally requiring 1-3 months of continuous use to see results, and their taste is unpleasant, leading to poor compliance. This herbal paste product adjusts the dosage, increasing the content of nourishing and replenishing herbs such as tortoise shell, polygonatum, donkey-hide gelatin, and deer antler gelatin. By decocting and mixing the herbs in two groups, the utilization rate of traditional Chinese medicine is improved, enhancing the effects of nourishing and replenishing the essence and marrow, and tonifying the liver and kidneys. Furthermore, the taste has been adjusted to be slightly sweet, ensuring compliance. Generally, effects can be seen after about 10-15 days of use, and clinical feedback has been positive.

[0028] Example 1 Basic information of outpatients Name: Zhang Moumou Gender: Female Age: 62 Date of visit: August 12, 2025 Follow-up appointment date: August 26, 2025 Initial diagnosis Chief complaint: Recurrent lower back pain for more than 1 year, which has worsened and been accompanied by limb weakness for 2 weeks.

[0029] Present Illness: One year ago, the patient developed lower back pain without any obvious cause. The pain worsened with activity and was slightly relieved by rest, but no systematic treatment was sought. Over the past six months, the frequency of pain has increased, with significant lower back soreness after prolonged sitting or standing, occasionally accompanied by leg cramps. The pain intensifies when turning over at night. Two weeks ago, after bending over to lift heavy objects, the lower back pain suddenly worsened, becoming persistent and aching, making it impossible to stand or walk for extended periods. Walking required support from the lower back, accompanied by weakness in both lower limbs, difficulty climbing stairs, and occasional knee weakness. Simultaneously, sleep quality has decreased, with frequent awakenings at night, followed by lower back stiffness that requires short periods of activity to relieve. Appetite is fair, and bowel movements are normal. Seeking further treatment, the patient presented to our hospital. The patient has a 3-year history of hypertension, with stable blood pressure control (regularly taking nifedipine sustained-release tablets, maintaining blood pressure around 130 / 80 mmHg). The patient denies a history of diabetes, coronary heart disease, or other chronic diseases, and has no history of drug allergies.

[0030] Four diagnostic methods data Visual examination: The patient is alert but lacks energy and has a pale complexion; the tongue is pale with a thin white coating, slightly swollen, and has teeth marks on the sides.

[0031] Auscultation: The voice was soft and the breathing was even, with no unusual odor.

[0032] Medical history: In addition to the above symptoms, the patient reported feeling cold, having cold hands and feet, especially at night, occasional dizziness, memory loss, good appetite and sleep, and regular bowel movements.

[0033] Palpation: The pulse is deep, thready, and weak, especially at the cun position.

[0034] Auxiliary examinations: Lumbar spine X-ray (August 11, 2025): Decreased vertebral body density in the lumbar spine, with osteophyte formation at the L3-L5 vertebral body margins, consistent with osteoporosis. Bone mineral density test (August 11, 2025): T-score = -2.8, indicating moderate osteoporosis.

[0035] Traditional Chinese Medicine Diagnosis: Bone atrophy (due to deficiency of liver and kidney, and insufficiency of qi and blood) Western medicine diagnosis: Moderate osteoporosis, grade 2 hypertension (intermediate risk) Treatment: Nourish the liver and kidneys, replenish qi and blood, strengthen muscles and bones. Prescription: Modified Turtle and Deer Paste (specific drugs and dosages are as follows): 10g of Polygonatum sibiricum, 10g of Lycium barbarum, 5g of processed tortoise shell, 5g of Carthamus tinctorius, 10g of Codonopsis pilosula, 10g of Cuscuta chinensis, 10g of Astragalus membranaceus, 10g of donkey-hide gelatin, 10g of deer antler gelatin, and 10g of Achyranthes bidentata.

[0036] Usage: The above is a one-day dosage. Prepare two packets of the paste. Take one packet each time, twice daily, with warm water after breakfast and dinner. Avoid spicy foods, alcohol, and fried foods. Avoid staying up late and maintain emotional stability. Follow up after 15 days of continuous use. During this period, it is recommended to drink approximately 2000ml of water daily and engage in light exercise such as walking or Tai Chi, avoiding strenuous activity.

[0037] Follow-up visit (15 days after starting medication) Chief complaint: Lower back pain has been significantly reduced, limb weakness has improved, and the patient can walk normally.

[0038] Symptom improvement: The patient's lower back pain has been significantly relieved, with only a slight soreness after prolonged bending or exertion, which is quickly relieved by rest. There is no obvious pain when turning over at night. The weakness in both lower limbs has disappeared, and the patient can walk up and down stairs independently without supporting their lower back. The walking distance has increased (from about 200 meters to about 800 meters). The symptoms of lower limb cramps have not recurred, the quality of sleep at night has improved, and the stiffness in the lower back has lessened upon waking. Symptoms of cold intolerance and cold hands and feet have improved, and the hands and feet can be kept warm. Symptoms of dizziness and memory loss have also been relieved.

[0039] Four diagnostic methods data Visual examination: The patient is in fair spirits and has a pale red complexion; the tongue is pale red with a thin white coating, the tongue is moist, and the teeth marks have lessened.

[0040] Auscultation: The patient's voice is clear, breathing is steady, and there are no unusual abnormalities.

[0041] Medical history: No obvious complaints of discomfort, normal appetite and bowel movements, good sleep at night, and no restriction on daily activities.

[0042] Palpation: The pulse is deep and thready but stronger than before, and the cun pulse is gradually recovering.

[0043] Evaluation of efficacy: After taking the medicine, osteoporosis-related symptoms were significantly improved, liver and kidney deficiency was nourished, qi and blood deficiency was replenished, and tendons and bones were nourished, with significant therapeutic effect; blood pressure was controlled stably (128 / 78 mmHg).

[0044] Example 2 Basic information of outpatients Name: Li Moumou Gender: Male Age: 70 Date of visit: September 5, 2025 Follow-up appointment date: September 20, 2025 Initial diagnosis Chief complaint: Soreness and pain in the lower back and knees, accompanied by a decrease in height for 2 years, which has worsened in the past month.

[0045] Present Illness: Two years ago, the patient gradually developed lower back and knee pain without any obvious cause. The pain was mainly dull and worsened after exertion, but could be relieved by rest. Over the past year, the patient felt that their height had decreased by about 2 cm, and a hunchback was becoming more pronounced, but this was not taken seriously. One month ago, the patient slipped and fell on a rainy day (without fracture), after which the lower back and knee pain significantly worsened, becoming persistent aches, especially at night and upon waking. Turning and bending were difficult, and the patient felt weak in the legs when walking, making climbing stairs difficult. Increased nocturia (2-3 times / night), lethargy, and a preference for warmth and cold were also observed. The patient has a 5-year history of chronic gastritis, and has been taking omeprazole enteric-coated capsules long-term. The patient denies a history of hypertension, diabetes, or drug allergies.

[0046] Four diagnostic methods data Visual examination: The patient appears alert but listless, with a dull and lackluster complexion, a thin build, and kyphosis. The tongue is pale purple with a white and greasy coating, and is large with petechiae on the edges.

[0047] Auscultation: The voice was low and deep, with occasional sighs, but no unusual odor.

[0048] Medical history: Lower back and knee pain, aversion to cold and cold limbs, frequent urination at night, poor appetite and loose stools, 1-2 times a day.

[0049] Palpation: The pulse is deep, thready, and hesitant; the pulse at both cun positions is weak.

[0050] Auxiliary examinations: Dual-energy X-ray absorptiometry (DXA) of the lumbar spine and hip (September 4, 2025): Average T-score of L1-L4 = -3.1, femoral neck T-score = -2.9, indicating severe osteoporosis. Lateral X-ray of the thoracic and lumbar spine: Multiple vertebral bodies of the thoracic and lumbar spine show wedge-shaped changes, and compression changes (old) in the T12 and L1 vertebral bodies.

[0051] Traditional Chinese Medicine Diagnosis: Bone Atrophy (Spleen and Kidney Yang Deficiency, Blood Stasis Obstructing the Collaterals) Western medical diagnosis: Severe osteoporosis, old compression fractures of the thoracic and lumbar vertebrae, chronic gastritis Treatment principle: Warm and tonify the spleen and kidneys, remove blood stasis and unblock the meridians, strengthen muscles and bones. The prescription is as follows: 10g of Polygonatum sibiricum (processed with wine), 10g of Lycium barbarum, 5g of processed tortoise shell, 5g of Carthamus tinctorius, 10g of Codonopsis pilosula, 10g of Cuscuta chinensis, 10g of donkey-hide gelatin, 10g of deer antler gelatin, 10g of Astragalus membranaceus, and 10g of Achyranthes bidentata.

[0052] The above is a one-day dosage. Prepare two packets of the paste. Take one packet each time, twice daily, with warm water after breakfast and dinner. Continue for 15 days, then return for a follow-up appointment. Avoid spicy foods, alcohol, and fried foods after breakfast and dinner. Avoid staying up late and maintain emotional stability. Return for a follow-up appointment after 15 days. During this period, it is recommended to drink approximately 2000ml of water daily and engage in light exercise such as walking or Tai Chi, avoiding strenuous activity.

[0053] Follow-up visit (15 days after starting medication) Chief complaint: Slight relief from lower back and knee pain, but no improvement in aversion to cold and fatigue.

[0054] Symptom improvement: The patient reported slight relief from lower back and knee pain, reduced morning stiffness, and the ability to dress and bend over to pick up objects independently. Walking was more stable than before, and the weakness when climbing stairs improved. Nocturia frequency decreased to 1-2 times per night. Symptoms of cold extremities lessened, mental state improved, appetite improved, and bowel movements became more formed. Daily activities improved.

[0055] Four diagnostic methods data: Visual examination: The patient's spirits have improved, and their complexion is more lustrous than before; the tongue is pale red with a thin white coating, the petechiae have decreased, and the tongue body is still slightly swollen.

[0056] Auscultation: The voice is louder and clearer than before, and the breathing is more even.

[0057] Medical history: No obvious severe pain in the lower back and knees, occasional mild soreness, improved appetite, regular bowel movements, and improved sleep.

[0058] Palpation: The pulse is deep and thready, but smoother than before, with a slight increase in the cun pulse.

[0059] Evaluation of efficacy: After taking the medication, the symptoms of spleen and kidney yang deficiency were significantly improved, blood stasis was resolved, the tendons and bones were warmed and nourished, and pain and functional impairment were significantly relieved. The efficacy was satisfactory. Continued consolidation treatment and regular monitoring of bone density are necessary.

[0060] Example 3 Basic information of outpatients Name: Wang Moumou Gender: Female Age: 58 Date of visit: October 10, 2025 Follow-up appointment date: October 25, 2025 Initial diagnosis Chief complaint: aches and pains in multiple joints throughout the body for 1.5 years, accompanied by heel pain for 6 months.

[0061] Present Illness: One and a half years ago, after menopause, the patient developed migratory aches and pains throughout her body, most notably in the shoulders, back, lower back, and both knees. The pain fluctuated in intensity, and she attributed it to "rheumatism" without seeking proper medical treatment. Over the past six months, the symptoms have worsened, with the pain becoming localized to the lower back and knees, and she has also experienced stabbing pain in both heels, especially upon waking or standing up after prolonged sitting, which is slightly relieved by activity. She feels weak when lifting heavy objects, experiences shoulder pain when combing her hair, and her knees feel sore and crack when climbing stairs. She also experiences dry mouth, dry eyes, irritability, insomnia, and night sweats. She has a history of good health, denies any history of hypertension, diabetes, or other chronic diseases, and has no history of drug allergies.

[0062] Four diagnostic methods data Visual examination: The patient is alert but anxious, thin, and has dry skin; the tongue is red with little moisture and coating, and is small and thin with cracks.

[0063] Auscultation: The patient's speech is clear, with occasional dry cough, but no unusual odor.

[0064] Medical history: Pain in the lower back, knees, and heels; dry mouth with thirst; dry eyes; hot flashes in the palms, soles, and chest; night sweats; insomnia with vivid dreams; dry stools; and yellow urine.

[0065] Palpation: The pulse is thready and rapid, and the radial pulse is deep and weak.

[0066] Auxiliary examinations: Whole-body bone mineral density test (October 9, 2025): Average T-score of lumbar spine L2-L4 = -2.5, T-score of left femoral neck = -2.4, indicating moderate osteoporosis. Rheumatoid factor, anti-CCP antibody, erythrocyte sedimentation rate, and C-reactive protein were all negative, ruling out rheumatoid arthritis.

[0067] Traditional Chinese Medicine Diagnosis: Bone atrophy (Liver and Kidney Yin deficiency, resulting in malnourishment of tendons and bones) Western medical diagnosis: Moderate postmenopausal osteoporosis Treatment principle: Nourish the liver and kidneys, nourish yin and clear heat, strengthen muscles and bones. The prescription is as follows: 10g of wolfberry, 5g of prepared tortoise shell, 10g of donkey-hide gelatin, 10g of deer antler gelatin (Dong'e), 10g of codonopsis, 10g of dodder seed, 10g of wine-processed polygonatum, 10g of astragalus, 5g of safflower, and 10g of achyranthes bidentata.

[0068] The above is a one-day dosage. Prepare two packets of the paste. Take one packet each time, twice daily, with warm water after breakfast and dinner. Continue for 15 days, then return for a follow-up appointment. Take warm after breakfast and dinner. Avoid spicy foods, alcohol, and fried foods. Avoid staying up late and maintain emotional stability. Return for a follow-up appointment after 15 days. During this period, it is recommended to drink approximately 2000ml of water daily and engage in light exercise such as walking or Tai Chi, avoiding strenuous activity.

[0069] Follow-up visit (15 days after starting medication) Chief complaint: Significant reduction in general body pain and heel pain; improvement in dry mouth, irritability, and night sweats.

[0070] Symptom improvement: The patient reported significant relief from lower back and knee pain; the morning heel tingling sensation had largely disappeared, and mobility was restored. Dry mouth and dry eyes symptoms lessened; hot flashes in the palms, soles, and chest, and night sweats significantly decreased; sleep quality improved, with the patient sleeping 6-7 hours per night. Bowel movements became more regular, and mental and emotional well-being was more stable than before.

[0071] Four diagnostic methods data: Visual examination: The patient's mental state has improved, the anxiety has lessened, and the skin is more moisturized than before; the tongue is pale red with a thin white coating, the body fluids are gradually returning, and the cracks are becoming shallower.

[0072] Auscultation: The patient's voice is calm and gentle, with no dry cough.

[0073] Medical history: Occasionally experiences mild soreness and weakness in the lower back and knees, without a fixed location of pain; slightly dry mouth; good appetite and sleep; regular bowel movements.

[0074] Palpation: The pulse is thready and slightly rapid, more moderate than before, with the cun pulse slightly more prominent.

[0075] Evaluation of therapeutic effect: After taking the medication, the liver and kidney yin deficiency was nourished, the deficiency heat was cleared, and the tendons and bones were nourished. Therefore, the pain and accompanying yin deficiency symptoms were significantly improved, and the therapeutic effect was good. Subsequent treatment should continue to nourish yin and replenish essence to consolidate the therapeutic effect, and long-term management of osteoporosis is recommended.

[0076] Comparative Example 1 Yang Moumou's gender / age: male, 68 years old Chief complaint: Lower back pain and weakness for 5 years. After taking Jiawei Guilu Gao for 3 months, the pain was slightly reduced, but the weakness and abdominal distension worsened.

[0077] Medical history: Long-term irregular eating habits, preference for raw and cold foods. Diagnosed with osteoporosis (T-score -3.1). No other major medical history.

[0078] Immediate diagnosis: Symptoms: lower back and knee pain and coldness, heaviness in the body, significant fatigue, loss of appetite, abdominal distension after meals, and loose stools.

[0079] Tongue and pulse: The tongue is pale and swollen with teeth marks on the edges, the coating is thick and greasy, and the pulse is deep and slippery.

[0080] Treatment process: 10g of wolfberry, 5g of prepared tortoise shell, 10g of donkey-hide gelatin, 10g of deer antler gelatin (Dong'e), 10g of dodder seed, 10g of wine-processed polygonatum, 1 bag of red astragalus, 5g of safflower, 10g of Sichuan achyranthes root (the above-mentioned modified tortoise and deer paste removed 10g of codonopsis).

[0081] Usage: The above is a one-day dosage. Prepare two packets of the paste. Take one packet each time, twice daily, with warm water after breakfast and dinner. Continue for 15 days, then return for a follow-up appointment. Avoid spicy foods, alcohol, and fried foods after breakfast and dinner. Avoid staying up late and maintain emotional stability. Return for a follow-up appointment after 15 days. During this period, it is recommended to drink approximately 2000ml of water daily and engage in light exercise such as walking or Tai Chi, avoiding strenuous activity.

[0082] Initially, the lower back pain was slightly relieved, but later, significant abdominal distension, indigestion, and a worsening feeling of heaviness in the body appeared. Overall, there was no significant improvement in mental state, and follow-up bone density tests showed no significant increase.

[0083] Analysis of reasons for unsatisfactory results: The patient's spleen and stomach function was insufficient, so after taking this herbal paste, there was no significant improvement in the lower back pain, and symptoms of indigestion appeared. At this time, the correct treatment should be to strengthen the spleen and resolve phlegm. At this time, Codonopsis pilosula should be added to strengthen the spleen and replenish qi, thereby increasing the digestive function of the spleen and stomach.

[0084] Comparative Example 2: Osteoporosis with Fractures Due to Blood Stasis and Obstruction of Collaterals Patient Information: Gender / Age: Female, 72 years old Chief complaint: Six months after surgery for a compression fracture of the lumbar spine, the patient experiences persistent pain and limited mobility.

[0085] Medical history: Diagnosed with osteoporosis 2 years ago, and intermittently took calcium supplements. Six months ago, suffered a compression fracture of the L1 vertebra due to a minor sprain and underwent minimally invasive surgery.

[0086] Immediate diagnosis: Symptoms: Fixed stabbing pain at the fracture site, especially at night; stiffness in the lower back; fear of touching; sallow complexion; lower back pain; difficulty in bearing weight.

[0087] Tongue and pulse: The tongue is dark purple with ecchymosis, the sublingual veins are tortuous, and the pulse is deep and hesitant.

[0088] Imaging: X-ray shows that the fracture line is still blurred and the local callus is growing slowly.

[0089] Treatment process: 10g of wolfberry, 5g of prepared tortoise shell, 10g of donkey-hide gelatin, 10g of deer antler gelatin (Dong'e), 10g of codonopsis, 10g of dodder seed, 10g of wine-processed polygonatum, 10g of astragalus, 10g of achyranthes root (the above-mentioned modified tortoise and deer paste omits 5g of safflower).

[0090] Usage: The above is a one-day dosage. Prepare two packets of the paste. Take one packet each time, twice daily, with warm water after breakfast and dinner. Continue for 15 days, then return for a follow-up appointment. Avoid spicy foods, alcohol, and fried foods after breakfast and dinner. Avoid staying up late and maintain emotional stability. Return for a follow-up appointment after 15 days. During this period, it is recommended to drink approximately 2000ml of water daily and engage in light exercise such as walking or Tai Chi, avoiding strenuous activity.

[0091] The patient felt better, but the stinging pain at the fracture site and the soreness in the lower back had not significantly subsided. In addition to tonifying the liver and kidneys, the treatment of osteoporosis should also focus on promoting blood circulation, removing blood stasis, and relieving pain. The treatment should emphasize both promoting blood circulation and tonifying the kidneys, and even promote blood circulation first and then tonify. Safflower can be used to promote blood circulation, remove blood stasis, and relieve pain.

[0092] Comparative Example 3 Patient Information: Gender / Age: Female, 58 years old Chief complaint: Multiple bone pains, hot flashes, and insomnia for 2 years.

[0093] Medical history: Menopausal for 5 years, with significant hot flashes, night sweats, irritability, and insomnia for the past 2 years, accompanied by heel pain and dull pain in the hypochondrium. Bone mineral density test showed a T-score of -2.8.

[0094] Immediate diagnosis: Symptoms: Bone pain is worse at night, accompanied by five-center heat (heat in the palms, soles, and chest), flushed cheeks in the afternoon, dry mouth and throat, dizziness and tinnitus, insomnia and dreaminess.

[0095] Tongue and pulse: The tongue is red with little moisture, the coating is thin and yellow, and the pulse is thready and rapid.

[0096] Treatment regimen: 10g wolfberry, 5g prepared tortoise shell, 10g donkey-hide gelatin, 10g deer antler gelatin (Dong'e), 10g codonopsis, 10g dodder seed, 10g wine-processed polygonatum, 10g astragalus, 5g safflower (the above modified tortoise and deer paste removed 10g of achyranthes bidentata).

[0097] Usage: The above is a one-day dosage. Prepare two packets of the paste. Take one packet each time, twice daily, with warm water after breakfast and dinner. Continue for 15 days, then return for a follow-up appointment. Avoid spicy foods, alcohol, and fried foods after breakfast and dinner. Avoid staying up late and maintain emotional stability. Return for a follow-up appointment after 15 days. During this period, it is recommended to drink approximately 2000ml of water daily and engage in light exercise such as walking or Tai Chi, avoiding strenuous activity.

[0098] After taking the medication, the patient experienced worsening dry mouth and constipation, and nighttime bone pain and a feeling of heat became more pronounced, along with exacerbated insomnia. The patient's condition deteriorated due to the excessive use of liver and kidney tonifying drugs, potentially leading to upward flaring of deficiency fire. The addition of Achyranthes bidentata (Chuan Niu Xi) was intended to guide the fire downwards while simultaneously enhancing the liver and kidney tonifying effects.

[0099] Those skilled in the art will readily understand that the above description is merely an embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A flavored turtle and deer paste, characterized in that, The flavored tortoise and deer paste contains preparation A and preparation B, as well as donkey-hide gelatin and deer antler gelatin. Preparation A contains Polygonatum sibiricum, wolfberry, prepared tortoise shell and safflower. Preparation B contains Codonopsis pilosula, Cuscuta chinensis, Achyranthes bidentata and Astragalus membranaceus.

2. The flavored turtle and deer paste according to claim 1, characterized in that, The flavored tortoise and deer paste contains, by weight, 8-12 parts of Polygonatum sibiricum, 8-12 parts of Lycium barbarum, 4-6 parts of processed tortoise shell, 4-6 parts of Carthamus tinctorius, 8-12 parts of Codonopsis pilosula, 8-12 parts of Cuscuta chinensis, 8-12 parts of Astragalus membranaceus, 8-12 parts of donkey-hide gelatin, 8-12 parts of deer antler gelatin, and 8-12 parts of Achyranthes bidentata.

3. The flavored tortoise and deer paste according to claim 1, characterized in that, The flavored tortoise and deer paste contains, by weight, 9-11 parts of Polygonatum sibiricum, 9-11 parts of Lycium barbarum, 4.5-5.5 parts of processed tortoise shell, 4.5-5.5 parts of safflower, 9-11 parts of Codonopsis pilosula, 9-11 parts of Cuscuta chinensis, 9-11 parts of Astragalus membranaceus, 9-11 parts of donkey-hide gelatin, 9-11 parts of deer antler gelatin, and 9-11 parts of Achyranthes bidentata.

4. The flavored turtle and deer paste according to claim 1, characterized in that, The flavored turtle and deer paste contains, by weight, 9.5-10.5 parts of Polygonatum sibiricum, 9.5-10.5 parts of Lycium barbarum, 4.8-5.2 parts of processed tortoise shell, 4.8-5.2 parts of safflower, 9.5-10.5 parts of Codonopsis pilosula, 9.5-10.5 parts of Cuscuta chinensis, 9.5-10.5 parts of Astragalus membranaceus, 9.5-10.5 parts of donkey-hide gelatin, 9.5-10.5 parts of deer antler gelatin, and 9.5-10.5 parts of Achyranthes bidentata.

5. The flavored turtle and deer paste according to claim 1, characterized in that, The flavored turtle and deer paste contains, by weight, 10 parts of Polygonatum sibiricum, 10 parts of Lycium barbarum, 5 parts of processed tortoise shell, 5 parts of safflower, 10 parts of Codonopsis pilosula, 10 parts of Cuscuta chinensis, 10 parts of Astragalus membranaceus, 10 parts of donkey-hide gelatin, 10 parts of deer antler gelatin, and 10 parts of Achyranthes bidentata.

6. The method for preparing the flavored turtle and deer paste according to any one of claims 1-5, characterized in that, The method includes the following steps: decocting preparation A and preparation B together according to the required ingredient ratio, filtering the decoction and concentrating it into a thick paste, adding donkey-hide gelatin and deer antler gelatin to melt, simmering over low heat to thicken the paste, and storing after cooling.

7. The method for preparing flavored turtle and deer paste according to claim 6, characterized in that, The ratio of the drug solution before and after concentration to a thick paste is 1.5-2.5:1; preferably, the ratio is 1.8-2.2:1; more preferably, the ratio is 2:

1.

8. The method for preparing the flavored turtle and deer paste according to claim 6, characterized in that, The storage is performed at 1-5℃.

9. The method for preparing the flavored turtle and deer paste according to claim 6, characterized in that, The storage is performed at 2-3℃.

10. The application of the flavored turtle and deer paste according to any one of claims 1-9, characterized in that, The application is the use of the flavored turtle and deer paste in the preparation of a medicine for treating osteoporosis.