Freeze-dried brewing grain for assisting long-term administration of chronic diseases of pets as well as preparation method and application of freeze-dried brewing grain

Abstract

The invention provides freeze-dried brewing grain for assisting long-term administration of chronic diseases of pets as well as a preparation method and application thereof, and relates to the field of pet food. The freeze-dried brewing grain for assisting long-term administration of the chronic diseases of the pets comprises a disease-adaptive freeze-dried staple food grain and administration auxiliary nutrition powder which are mutually independent. The administration auxiliary nutrition powder is prepared from the following components: a yeast extract, pork liver hydrolyzed powder, silicon dioxide micro powder, xanthan gum, guar gum, alpha-casein hydrolysate, L-theanine, a milk thistle extract, S-adenosylmethionine and microencapsulated krill oil. According to the freeze-dried brewing grain for assisting long-term administration of the chronic diseases of the pets, on the premise of seamlessly integrating the pet administration process, the medicine smell is effectively and efficiently masked, long-term administration is facilitated, and the nutritional requirements of the pets suffering from the chronic diseases are further met; therefore, the problem that long-term oral administration of pets is difficult is solved, stress and anxiety of the pets and owners are relieved, and targeted nutrition support is synchronously provided for the pets.

Description

Technical Field

[0001] This invention relates to the field of pet food, and in particular to a freeze-dried instant food for long-term administration of medication to pets with chronic diseases, its preparation method, and its application. Background Technology

[0002] The current trend of keeping cats and dogs as pets has evolved from its past functional purpose of guarding the house or catching mice to a profound emotional bond and a way of expressing lifestyle. Pets play a vital role as emotional companions and are considered family members by many owners. Cats and dogs suffering from chronic diseases (such as kidney disease, heart disease, thyroid dysfunction, arthritis, diabetes, etc.) require long-term or even lifelong medication. However, current medication methods have the following drawbacks: 1. Forced feeding stress: Directly administering or force-feeding medication can easily trigger strong resistance, vomiting, and excessive salivation in pets, leading to inaccurate drug dosage and severely damaging the trust relationship between humans and pets, which can easily cause stress and psychological trauma in pets.

[0003] 2. Drug-sensory rejection: Crushing tablets or opening capsules and mixing them into food often causes pets to refuse to eat due to their strong bitter taste or special smell. Clever pets may even be able to pick out the medication or refuse that type of food altogether.

[0004] 3. The burden of medication administration on pet owners: The task of administering medication to pets every day brings enormous mental stress and wastes time for pet owners. Some owners even consider abandoning their pets or discontinuing treatment because of the difficulty in administering medication.

[0005] To assist in administering medication to cats and dogs, existing technologies include "pill pockets," which are moldable pet treats specifically designed to encapsulate pills / capsules. Their core function is to conceal the medication, allowing pets to ingest the medication along with the treat without their knowledge, thus replacing forced administration. However, existing pill pockets are mostly high-fat, high-calorie treats, unsuitable for long-term, daily use by pets with chronic diseases. Furthermore, they are only effective for solid medications, with limited effectiveness for liquid medications, concurrent administration of multiple medications, and extremely picky eaters.

[0006] Based on this, a freeze-dried instant food is provided as a daily drug delivery carrier to assist in long-term administration of medication for pets with chronic diseases. Under the premise of seamless integration with the pet drug delivery process, it effectively and efficiently masks the drug odor, facilitates long-term administration, and further meets the nutritional needs of pets suffering from chronic diseases. This solves the problem of difficulty in long-term oral administration of pets, reduces stress and anxiety for pets and owners, and provides targeted nutritional support for pets at the same time. It has important technical significance and research value. Summary of the Invention

[0007] To address the technical problems existing in the prior art, this invention provides a freeze-dried instant food, its preparation method, and its application for assisting long-term administration of medication to pets with chronic diseases. Under the premise of seamlessly integrating the pet medication process, it effectively and efficiently masks the odor of the drug, facilitates long-term administration, and further meets the nutritional needs of pets suffering from chronic diseases. This solves the problem of difficulty in long-term oral administration to pets, reduces stress and anxiety for pets and their owners, and simultaneously provides targeted nutritional support for pets.

[0008] To solve the above technical problems, the technical solution adopted by the present invention is as follows: A freeze-dried instant food for pets to assist in long-term administration of medication for chronic diseases, comprising independent disease-adapted freeze-dried staple food and medication supplementary nutritional powder. The disease-adapted freeze-dried staple food is one of the following: freeze-dried staple food for kidney disease support, freeze-dried staple food for heart disease support, and freeze-dried staple food for general diseases support. The freeze-dried staple food for supporting kidney disease includes the following ingredients: cod, chicken breast, egg white powder, and pumpkin powder; the freeze-dried staple food for supporting heart disease includes the following ingredients: cod, chicken breast, egg white powder, and pumpkin powder; the freeze-dried staple food for supporting general diseases includes the following ingredients: cod, chicken breast, egg white powder, pumpkin powder, and purple sweet potato powder. The medication-aid nutritional powder includes the following ingredients: yeast extract, hydrolyzed pork liver powder, silica micro powder, xanthan gum, guar gum, α-casein hydrolysate, L-theanine, milk thistle extract, S-adenosylmethionine, and microencapsulated krill oil.

[0009] Preferably, the weight ratio of disease-adapted freeze-dried staple food to drug-assisted nutritional powder is 10:1.

[0010] Preferably, in the freeze-dried staple food for supporting kidney disease, the weight ratio of cod meat, chicken breast meat, egg white powder, and pumpkin powder is 5:2:1:1; In the freeze-dried staple food for heart disease support, the weight ratio of cod meat, chicken breast, egg white powder, and pumpkin powder is 4:3:1:1. In the aforementioned general disease support-type freeze-dried staple food, the weight ratio of cod meat, chicken breast, egg white powder, pumpkin powder, and purple sweet potato powder is 3:3:1:1:1.

[0011] Preferably, the medication-aiding nutritional powder, by weight, comprises the following components: 15-16 parts yeast extract, 7-8 parts hydrolyzed pig liver powder, 1.9-2.3 parts silica micro powder, 1-1.2 parts xanthan gum, 1-1.2 parts guar gum, 1-1.2 parts α-casein hydrolysate, 0.5-0.7 parts L-theanine, 1.4-1.5 parts milk thistle extract, 0.7-0.9 parts S-adenosylmethionine, and 3-3.6 parts microencapsulated krill oil.

[0012] Furthermore, the preparation method of the microencapsulated krill oil includes the following steps: Step S1. Mix deionized water, sodium octenyl succinate starch, maltodextrin, whey protein, and sodium ascorbate evenly to obtain an aqueous solution; Step S2. Under stirring conditions, krill oil is added to the aqueous solution and sheared and emulsified to obtain a crude emulsion; Step S3. After high-pressure homogenization, the crude emulsion is freeze-dried to obtain microencapsulated krill oil.

[0013] Preferably, in step S1, the weight ratio of deionized water, sodium octenyl succinate starch, maltodextrin, whey protein, and sodium ascorbate is 185-190:14.3-14.7:53-56:4.5-5.5:0.5-0.6.

[0014] Preferably, in step S2, the rate at which krill oil is added to the aqueous solution is 2-2.8 g / min; The rotation speed for shear emulsification is 10,000-12,000 rpm, and the shear emulsification time is 5-10 min; The mass ratio of the aqueous solution to krill oil is 10.2-10.3:1.

[0015] Preferably, in step S3, the high-pressure homogenization process controls the first-stage homogenization pressure to be 280-300 Bar and the second-stage pressure to be 40-50 Bar, and the homogenization is repeated 3 times.

[0016] A method for preparing freeze-dried instant food for long-term administration of medication for chronic diseases in pets, as described above, includes the following steps: preparing disease-adapted freeze-dried staple food and preparing medication supplementary nutritional powder. The method for preparing disease-adapted freeze-dried staple food is as follows: the raw materials of the disease-adapted freeze-dried staple food are cut into granules, mixed evenly, and a mixture is obtained; the mixture is freeze-dried until the moisture content is ≤5wt% to obtain the disease-adapted freeze-dried staple food. The method for preparing the drug administration auxiliary nutritional powder is as follows: yeast extract, pig liver hydrolysate, silica micro powder, xanthan gum, guar gum, α-casein hydrolysate, L-theanine, milk thistle extract, S-adenosylmethionine, and microencapsulated krill oil are mixed evenly to obtain the drug administration auxiliary nutritional powder.

[0017] Preferably, in the preparation of disease-adapted freeze-dried staple food, freeze drying involves rapidly freezing the mixture and then placing it in a vacuum environment of 10-50 Pa, followed by a first drying and a second drying. The first drying process involves raising the material temperature from -35℃ to 0℃ at a heating rate of 5-8℃ / h, and then maintaining the temperature for 8-12 hours. The secondary drying involves raising the temperature to 25-35℃ after the primary drying and maintaining the temperature for 3-5 hours.

[0018] An application of the aforementioned freeze-dried instant food for long-term administration of medication for chronic diseases in pets involves mixing the disease-adapted freeze-dried staple food, medication supplementary nutritional powder, and medication evenly in a weight ratio of 10:1:1, then adding drinking water and stirring evenly before feeding it to the pet. The drug is either a powder or a liquid.

[0019] Compared with the prior art, the beneficial effects of the present invention are as follows: (1) The freeze-dried instant food of the present invention, which assists in long-term administration of pet chronic diseases, effectively and efficiently masks the smell of drugs through a synergistic strategy of specific flavor masking, texture optimization and positive behavior association, while seamlessly integrating the pet administration process, so that the administration process is stress-free and imperceptible, and convenient for long-term administration. In addition, the freeze-dried staple food base is adjusted according to different types of chronic diseases to further meet the nutritional needs of pets suffering from chronic diseases. The administration behavior is completely integrated into the pet's most anticipated meal process every day, which completely eliminates the pet's pre-existing fear and stress of administration, solves the problem of difficulty in long-term oral administration of pets, and reduces the anxiety of pet owners.

[0020] (2) The freeze-dried instant food of the present invention, which assists in long-term administration of medication for chronic diseases in pets, achieves flavor deception through efficient flavor masking. It uses a "flavor bomb" composed of yeast extract and hydrolyzed pig liver powder to establish a strong delicious signal at the olfactory and gustatory levels, completely suppressing the unpleasant flavor of the drug. At the same time, it uses texture optimization and concealment methods for drug encapsulation and adsorption, with a high viscoelastic soup forming the encapsulation layer and silica micropowder forming the adsorption core. Whether it is a solid or liquid drug, it can be effectively hidden in it, and the drug will not be separated during the pet's licking process. It also uses positive behavior association psychological guidance methods to link the pet's most enjoyable eating with the most disliked medication. It reduces the pet's tension through mood-soothing ingredients. Long-term use can reshape the pet's cognition of medication behavior, turning fear into anticipation. Furthermore, the freeze-dried instant food of the present invention, which assists in long-term administration of medication for chronic diseases in pets, also reduces the potential burden on organs from long-term medication through the liver-protecting and kidney-protecting ingredients of the medication-assisting nutritional powder, and provides targeted health care according to the physical characteristics of pets with chronic diseases. Furthermore, for pet owners, there is no longer a need to outwit their pets by administering medication daily. Simply mixing and preparing the medicine makes it easy to administer, effectively relieving the owner's anxiety and care burden, thereby improving treatment compliance and the quality of life for both the pet and the owner.

[0021] (3) The preparation method of the freeze-dried instant food for long-term administration of pet chronic diseases of the present invention can be obtained by purchasing raw materials through commercial channels, which is easy to obtain. The process is simple and the preparation process is easy to control, which is suitable for industrial-scale production. Detailed Implementation

[0022] To provide a clearer understanding of the technical features, objectives, and effects of this invention, specific embodiments are now described. It should be noted that the following detailed descriptions are exemplary and intended to provide further explanation of the invention. Unless otherwise specified, all technical and scientific terms used in this invention have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains.

[0023] It should be noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the exemplary embodiments of the present invention. As used herein, "first," "second," etc., are used to distinguish similar objects and are not used to describe a particular order or sequence. Furthermore, it should be understood that when the terms "comprising" and / or "including" are used in this specification, they indicate the presence of features, steps, operations, devices, components, and / or combinations thereof.

[0024] This invention provides a freeze-dried instant food for pets to assist in long-term medication for chronic diseases, comprising: disease-specific freeze-dried staple food and medication supplementary nutritional powder, the weight ratio of which is 9.5-10.5:1. To use this freeze-dried instant food for pets to assist in long-term medication for chronic diseases, the disease-specific freeze-dried staple food, medication supplementary nutritional powder, and medication are mixed evenly, then drinking water is added and stirred before consumption.

[0025] The disease-adapted freeze-dried staple food is one of the following: freeze-dried staple food for kidney disease support, freeze-dried staple food for heart disease support, or freeze-dried staple food for general diseases support.

[0026] The aforementioned kidney disease supportive freeze-dried staple food includes the following ingredients: cod meat, chicken breast meat, egg white powder, and pumpkin powder; the weight ratio of cod meat, chicken breast meat, egg white powder, and pumpkin powder is 5-5.5:2-2.3:1-1.1:1-1.1.

[0027] The freeze-dried staple food for heart disease support includes the following ingredients: cod meat, chicken breast, egg white powder, and pumpkin powder; the weight ratio of cod meat, chicken breast, egg white powder, and pumpkin powder is 4-4.5:3-3.2:0.9-1:0.9-1.

[0028] The general disease support-type freeze-dried staple food includes the following ingredients: cod meat, chicken breast meat, egg white powder, pumpkin powder, and purple sweet potato powder; the weight ratio of cod meat, chicken breast meat, egg white powder, pumpkin powder, and purple sweet potato powder is 3-3.5:3-3.5:1-1.2:1-1.2:1-1.2.

[0029] The medication-aid nutritional powder, by weight, comprises the following components: a. Flavor masking and adsorption components (reduce the difficulty of administering medication through flavor masking or adsorption): 10-20 parts of yeast extract (provides a strong "meaty" flavor and effectively covers bitterness), 5-10 parts of hydrolyzed pig liver powder (natural palatability and rich flavor), and 1-3 parts of silica micro powder (large specific surface area, which can physically adsorb liquid drugs and prevent them from freely diffusing and producing odors). b. Highly viscoelastic coating matrix (which forms a thick, slippery gel-like liquid when it comes into contact with water, which can coat tablets, powders, or silica containing medicine, making them difficult to detect when swallowed by pets): 0.5-1.5 parts xanthan gum, 0.5-1.5 parts guar gum.

[0030] c. Mood-soothing and stress-relieving components: 0.5-1.5 parts of α-casein hydrolysate (for rapid relief of anxiety before and after administration), and 0.3-0.8 parts of L-theanine (for inducing a relaxed state). d. Protective nutritional support for liver and kidney: 1-2 parts milk thistle extract (protects liver cells and assists in drug metabolism), 0.5-1 part S-adenosylmethionine (SAM-e) (supports liver detoxification function), 2-4 parts microencapsulated krill oil (provides Omega-3 fatty acids) (anti-inflammatory and protects kidney function).

[0031] The preparation method of microencapsulated krill oil includes the following steps: Step S1. Add deionized water, sodium octenyl succinate starch HI-CAP 100, maltodextrin, whey protein, and sodium ascorbate to a preparation tank. Stir and heat to 32-36℃, keep warm and stir for 20-40 minutes until all materials are completely dissolved. Then cool to room temperature to obtain an aqueous solution for later use.

[0032] The weight ratio of deionized water, sodium octenyl succinate starch HI-CAP 100, maltodextrin, whey protein, and sodium ascorbate is 185-190:14.3-14.7:53-56:4.5-5.5:0.5-0.6.

[0033] Step S2. Transfer the aqueous solution to an emulsification tank. Under stirring conditions of 2800-3200 rpm, add krill oil at a feeding rate of 2-3 g / min. After the krill oil is added, increase the rotation speed to 10000-12000 rpm and shear for 5-10 min to obtain a crude emulsion.

[0034] The mass ratio of the aqueous solution to krill oil is 10-10.5:1.

[0035] Step S3. Transfer the crude emulsion to a high-pressure homogenizer for circulating homogenization. Control the primary homogenization pressure to be 250-300 Bar and the secondary homogenization pressure to be 40-50 Bar. Circulate the homogenizer 2-3 times to obtain the homogenized material. Transfer the homogenized material to a freeze dryer for freeze drying and sieve to obtain microencapsulated krill oil.

[0036] This invention provides a freeze-dried instant food for long-term administration of medication to pets with chronic diseases. Through a synergistic strategy of specific flavor masking, texture optimization, and positive behavior association, it effectively and efficiently masks the odor of drugs while seamlessly integrating the pet's medication process. This makes the administration process stress-free and imperceptible, facilitating long-term administration. Furthermore, the freeze-dried food base can be adjusted to suit different types of chronic diseases, further meeting the nutritional needs of pets suffering from chronic illnesses. By fully integrating the medication process into the pet's most anticipated daily mealtime, it completely eliminates the pet's pre-existing fear and stress associated with medication, solves the problem of difficulty in long-term oral medication for pets, and reduces the anxiety of pet owners.

[0037] Specifically, this treatment employs highly efficient flavor masking techniques to deceive the taste buds during drug administration. A "flavor bomb" composed of yeast extract and hydrolyzed pig liver powder creates a strong delicious signal at the olfactory and gustatory levels, completely suppressing the unpleasant taste of the medication. Simultaneously, it utilizes optimized texture and concealment techniques for drug encapsulation and adsorption. A highly viscoelastic broth forms the encapsulation layer, while silica micropowder forms the adsorption core. Whether the drug is solid or liquid, it can be effectively concealed within, preventing separation during pet licking. Furthermore, it employs positive behavioral association techniques to link the pet's most enjoyable eating experience with their least favorite activity—taking medication. Emotionally soothing ingredients reduce the pet's stress, and long-term use can reshape the pet's perception of drug administration, transforming fear into anticipation.

[0038] Furthermore, the freeze-dried instant food of the present invention, which assists in the long-term administration of medication for pets with chronic diseases, can further reduce the potential burden on organs from long-term medication by using liver- and kidney-protecting ingredients in the medication supplement powder, and provides targeted health care based on the physical characteristics of pets with chronic diseases.

[0039] This invention also provides a method for preparing the aforementioned freeze-dried instant food for long-term administration of medication for chronic pet diseases, comprising the following steps: (1) Preparation of disease-adapted freeze-dried staple food ① Raw material pretreatment: After preparing the raw materials for freeze-dried staple foods adapted to different diseases, they are cut into particles with a particle size of 0.7-0.9cm; after being mixed evenly according to the weight parts, a mixture is obtained.

[0040] ② Spreading and quick-freezing: Spread the mixture onto freeze-drying trays, controlling the thickness of the spread to 1.5-2cm, and then send it into a quick-freezing chamber for rapid freezing in an environment of -40 to -35℃, so that the core temperature of the material drops to below -18℃, and the frozen material is obtained.

[0041] ③ Vacuum freeze-drying: Transfer the quick-frozen material into the vacuum freeze-drying chamber, start the vacuum pump, maintain the vacuum degree in the chamber at 10-50 Pa, and then dry in two stages: Primary drying (sublimation drying): The material temperature is raised from -35℃ to 0℃ at a heating rate of 5-8℃ / h, and then kept at that temperature for 8-12 hours to remove most of the free water.

[0042] Secondary drying (analytical drying): Continue heating to 25-35℃ and keep warm for 3-5 hours to remove bound water until the moisture content of the material is ≤5wt%, thus obtaining compound freeze-dried staple food.

[0043] ④ Discharge and Packaging: After freeze-drying, nitrogen gas is introduced into the vacuum freeze-drying chamber to break the air. In a dry environment with a relative humidity of ≤20%, the compound freeze-dried staple food is packed into aluminum foil bags and sealed with nitrogen.

[0044] (2) Preparation of drug administration auxiliary nutritional powder Add the raw materials required for the drug administration auxiliary nutritional powder to a three-dimensional motion mixer according to the weight proportions, mix for 20-30 minutes until uniformly mixed to obtain the drug administration auxiliary nutritional powder; package the drug administration auxiliary nutritional powder into aluminum foil bags and seal them.

[0045] (3) Finished product assembly The weight ratio of disease-adapted freeze-dried staple food to medication supplementary nutritional powder is 9.5-10.5:1. The relatively independently packaged disease-adapted freeze-dried staple food and medication supplementary nutritional powder are placed together in the same outer packaging bag to produce freeze-dried instant food for long-term administration of medication for pets with chronic diseases.

[0046] This invention also provides the application of the freeze-dried instant food for long-term administration of medication for chronic diseases in pets. The freeze-dried food is mixed evenly with the medication, the medication supplementary nutritional powder, and the medicine in a weight ratio of 9.5-10.5:1:1. Then, 1.5-2.5 times the weight of drinking water is added, stirred, and prepared before being given to the pet.

[0047] The drug is in the form of powder or liquid, specifically one of the following: powder, crushed tablets, capsule contents, or liquid.

[0048] To enable those skilled in the art to better understand the technical solution of the present invention, the present invention will be further described below in conjunction with some specific embodiments.

[0049] Example 1 This embodiment provides a freeze-dried instant food for long-term administration of medication for chronic diseases in pets (specifically for chronic kidney disease), comprising: disease-adapted freeze-dried staple food and medication supplementary nutritional powder, which are independent of each other; the weight ratio of the disease-adapted freeze-dried staple food to the medication supplementary nutritional powder is 10:1.

[0050] The disease-adapted freeze-dried staple food is a supportive freeze-dried staple food for kidney disease.

[0051] The kidney disease supportive freeze-dried staple food includes the following ingredients: cod meat, chicken breast meat, egg white powder, and pumpkin powder; the weight ratio of cod meat, chicken breast meat, egg white powder, and pumpkin powder is 5:2:1:1.

[0052] The medication-aid nutritional powder, by weight, comprises the following components: a. Flavor masking and adsorption components: 15 parts yeast extract, 8 parts hydrolyzed pork liver powder, and 2 parts silica micro powder; b. Highly viscoelastic coating matrix: 1 part xanthan gum, 1 part guar gum; c. Mood-soothing and stress-relieving ingredients: 1 part α-casein hydrolysate, 0.5 parts L-theanine; d. Protective nutritional support for liver and kidney: 1.5 parts milk thistle extract, 0.8 parts S-adenosylmethionine (SAM-e), and 3 parts microencapsulated krill oil.

[0053] The preparation method of microencapsulated krill oil includes the following steps: Step S1. Add deionized water, sodium octenyl succinate starch HI-CAP 100, maltodextrin, whey protein, and sodium ascorbate to a preparation tank. Stir and heat to 35°C, keep warm and stir for 30 minutes until all materials are completely dissolved. Then cool to room temperature to obtain an aqueous solution for later use.

[0054] The weight ratio of deionized water, sodium octenyl succinate starch HI-CAP 100, maltodextrin, whey protein, and sodium ascorbate is 187:14.5:55:5:0.5.

[0055] Step S2. Transfer the aqueous solution to an emulsification tank, add krill oil at a feeding rate of 2.5 g / min under stirring at 3000 rpm. After the krill oil is added, increase the rotation speed to 12000 rpm and shear for 6 min to obtain a crude emulsion.

[0056] The mass ratio of the aqueous solution to krill oil is 10.2:1.

[0057] Step S3. Transfer the crude emulsion to a high-pressure homogenizer for circulating homogenization. Control the first-stage homogenization pressure at 300 Bar and the second-stage pressure at 50 Bar. Circulate homogenize 3 times to obtain homogenized material. Transfer the homogenized material to a freeze dryer for freeze drying and sieve to obtain microencapsulated krill oil.

[0058] This embodiment also provides a method for preparing the aforementioned freeze-dried instant food for long-term administration of medication for chronic diseases in pets, including the following steps: (1) Preparation of disease-adapted freeze-dried staple food ① Raw material pretreatment: After preparing the raw materials according to the supportive freeze-dried staple food for kidney disease, the raw materials are cut into particles with a particle size of 0.8cm; after being mixed evenly according to the weight parts, a mixture is obtained.

[0059] ② Spreading and quick-freezing: Spread the mixture onto freeze-drying trays, controlling the thickness of the spread to 2cm, and then send it into a quick-freezing chamber for rapid freezing in an environment of -40℃ to -35℃, so that the core temperature of the material drops to below -18℃, and the frozen material is obtained.

[0060] ③ Vacuum freeze-drying: Transfer the quick-frozen material into the vacuum freeze-drying chamber, start the vacuum pump, maintain the vacuum degree in the vacuum freeze-drying chamber at 30Pa, and then perform drying in two stages: Primary drying (sublimation drying): The material temperature is raised from -35℃ to 0℃ at a heating rate of 6℃ / h, and then kept at that temperature for 10 hours to remove most of the free water.

[0061] Secondary drying (analytical drying): Continue heating to 30℃ and keep drying for 4 hours to remove bound water until the moisture content of the material is ≤5wt%, thus obtaining compound freeze-dried staple food.

[0062] ④ Discharge and Packaging: After freeze-drying, nitrogen gas is introduced into the vacuum freeze-drying chamber to break the air. In a dry environment with a relative humidity of ≤20%, the compound freeze-dried staple food is packed into aluminum foil bags and sealed with nitrogen.

[0063] (2) Preparation of drug administration auxiliary nutritional powder Add the raw materials required for the drug administration auxiliary nutritional powder to a three-dimensional motion mixer according to the weight proportions, mix for 30 minutes until uniformly mixed to obtain the drug administration auxiliary nutritional powder; package the drug administration auxiliary nutritional powder into aluminum foil bags and seal them.

[0064] (3) Finished product assembly By placing the relatively independently packaged disease-adapted freeze-dried staple food and the medication supplementary nutritional powder in the same outer packaging bag at a weight ratio of 10:1, a freeze-dried instant food for long-term administration of medication for pets with chronic diseases is produced.

[0065] This embodiment also provides the application of the freeze-dried instant food for long-term administration of medication for chronic diseases in pets. The freeze-dried food adapted to the disease, the medication supplementary nutritional powder and the medicine (such as phosphorus-lowering drug) are mixed evenly in a weight ratio of 10:1:1. After mixing evenly, twice the weight of drinking water is added and stirred for 30 seconds to prepare the food. It can then be provided to pets suffering from chronic kidney disease.

[0066] Example 2 This embodiment provides a freeze-dried instant food for long-term administration of medication for chronic diseases in pets (specifically for heart disease), comprising: disease-adapted freeze-dried staple food and medication supplementary nutritional powder, which are independent of each other; the weight ratio of the disease-adapted freeze-dried staple food to the medication supplementary nutritional powder is 10:1.

[0067] The disease-adapted freeze-dried staple food is a heart disease support freeze-dried staple food.

[0068] The freeze-dried staple food for heart disease support includes the following ingredients: cod, chicken breast, egg white powder, and pumpkin powder; the weight ratio of cod, chicken breast, egg white powder, and pumpkin powder is 4:3:1:1.

[0069] The medication-aid nutritional powder, by weight, comprises the following components: a. Flavor masking and adsorption components: 15 parts yeast extract, 7 parts hydrolyzed pork liver powder, and 2.3 parts silica micro powder; b. Highly viscoelastic coating matrix: 1.2 parts xanthan gum, 1.2 parts guar gum; c. Mood-soothing and stress-relieving ingredients: 1 part α-casein hydrolysate, 0.6 parts L-theanine; d. Protective nutritional support for liver and kidney: 1.4 parts milk thistle extract, 0.7 parts S-adenosylmethionine (SAM-e), and 3.5 parts microencapsulated krill oil.

[0070] The preparation method of microencapsulated krill oil includes the following steps: Step S1. Add deionized water, sodium octenyl succinate starch HI-CAP 100, maltodextrin, whey protein, and sodium ascorbate to a preparation tank. Stir and heat to 32°C, keep warm and stir for 40 minutes until all materials are completely dissolved. Then cool to room temperature to obtain an aqueous solution for later use.

[0071] The weight ratio of deionized water, sodium octenyl succinate starch HI-CAP 100, maltodextrin, whey protein, and sodium ascorbate is 185:14.3:53:4.5:0.5.

[0072] Step S2. Transfer the aqueous solution to an emulsification tank, add krill oil at a feeding rate of 2.8 g / min under stirring at 3200 rpm. After the krill oil is added, increase the rotation speed to 12000 rpm and shear for 5 min to obtain a crude emulsion.

[0073] The mass ratio of the aqueous solution to krill oil is 10.3:1.

[0074] Step S3. Transfer the crude emulsion to a high-pressure homogenizer for circulating homogenization. Control the first-stage homogenization pressure at 280 Bar and the second-stage pressure at 40 Bar. Circulate homogenize 3 times to obtain homogenized material. Transfer the homogenized material to a freeze dryer for freeze drying and sieve to obtain microencapsulated krill oil.

[0075] This embodiment also provides a method for preparing the aforementioned freeze-dried instant food for long-term administration of medication for chronic diseases in pets, including the following steps: (1) Preparation of disease-adapted freeze-dried staple food ① Raw material pretreatment: After preparing the raw materials according to the heart support type freeze-dried staple food, cut them into particles with a particle size of 0.7cm; mix them evenly according to the weight parts to obtain a mixture.

[0076] ② Spreading and quick-freezing: Spread the mixture onto freeze-drying trays, controlling the thickness of the spread to 2cm, and then send it into a quick-freezing chamber for rapid freezing in an environment of -35℃, so that the core temperature of the material drops to below -18℃, and the frozen material is obtained.

[0077] ③ Vacuum freeze-drying: Transfer the quick-frozen material into the vacuum freeze-drying chamber, start the vacuum pump, maintain the vacuum degree in the vacuum freeze-drying chamber at 35Pa, and then dry in two stages: Primary drying (sublimation drying): The material temperature is raised from -35℃ to 0℃ at a heating rate of 6℃ / h, and then kept at that temperature for 12 hours to remove most of the free water.

[0078] Secondary drying (analytical drying): Continue heating to 25℃ and keep drying for 5 hours to remove bound water until the moisture content of the material is ≤5wt%, thus obtaining compound freeze-dried staple food.

[0079] ④ Discharge and Packaging: After freeze-drying, nitrogen gas is introduced into the vacuum freeze-drying chamber to break the air. In a dry environment with a relative humidity of ≤20%, the compound freeze-dried staple food is packed into aluminum foil bags and sealed with nitrogen.

[0080] (2) Preparation of drug administration auxiliary nutritional powder Add the raw materials required for the drug administration auxiliary nutritional powder to a three-dimensional motion mixer according to the weight proportions, mix for 25 minutes until uniformly mixed to obtain the drug administration auxiliary nutritional powder; package the drug administration auxiliary nutritional powder into aluminum foil bags and seal them.

[0081] (3) Finished product assembly By placing the relatively independently packaged disease-adapted freeze-dried staple food and the medication supplementary nutritional powder in the same outer packaging bag at a weight ratio of 10:1, a freeze-dried instant food for long-term administration of medication for pets with chronic diseases is produced.

[0082] This embodiment also provides the application of the freeze-dried instant food for long-term administration of medication for chronic diseases in pets. The freeze-dried food adapted to the disease, the medication supplementary nutritional powder and the medicine (such as positive inotropic drug) are mixed evenly at a weight ratio of 10:1:1. After mixing evenly, 1.8 times the weight of drinking water is added and stirred for 30 seconds. The mixture is then ready to be served to pets with heart disease.

[0083] Example 3 This embodiment provides a freeze-dried instant food for long-term administration of medication for pets with chronic diseases (for other common chronic diseases), comprising: disease-adapted freeze-dried staple food and medication supplementary nutritional powder, which are independent of each other; the weight ratio of the disease-adapted freeze-dried staple food and the medication supplementary nutritional powder is 10:1.

[0084] The disease-adapted freeze-dried staple food is a general disease support-type freeze-dried staple food.

[0085] The general disease support-type freeze-dried staple food includes the following ingredients: cod meat, chicken breast meat, egg white powder, pumpkin powder, and purple sweet potato powder; the weight ratio of cod meat, chicken breast meat, egg white powder, pumpkin powder, and purple sweet potato powder is 3:3:1:1:1.

[0086] The medication-aid nutritional powder, by weight, comprises the following components: a. Flavor masking and adsorption components: 16 parts yeast extract, 8 parts hydrolyzed pork liver powder, and 1.9 parts silica micro powder; b. Highly viscoelastic coating matrix: 1.1 parts xanthan gum, 1.1 parts guar gum; c. Mood-soothing and stress-relieving ingredients: 1.2 parts α-casein hydrolysate, 0.7 parts L-theanine; d. Protective nutritional support for liver and kidney: 1.4 parts milk thistle extract, 0.9 parts S-adenosylmethionine (SAM-e), and 3.6 parts microencapsulated krill oil.

[0087] The preparation method of microencapsulated krill oil includes the following steps: Step S1. Add deionized water, sodium octenyl succinate starch HI-CAP 100, maltodextrin, whey protein, and sodium ascorbate to a preparation tank. Stir and heat to 36°C, keep warm and stir for 20 minutes until all materials are completely dissolved. Then cool to room temperature to obtain an aqueous solution for later use.

[0088] The weight ratio of deionized water, sodium octenyl succinate starch HI-CAP 100, maltodextrin, whey protein, and sodium ascorbate is 190:14.7:56:5.5:0.6.

[0089] Step S2. Transfer the aqueous solution to an emulsification tank, add krill oil at a feeding rate of 2 g / min under stirring at 2800 rpm. After the krill oil is added, increase the rotation speed to 10000 rpm and shear for 10 min to obtain a crude emulsion.

[0090] The mass ratio of the aqueous solution to krill oil is 10.2:1.

[0091] Step S3. Transfer the crude emulsion to a high-pressure homogenizer for circulating homogenization. Control the first-stage homogenization pressure at 300 Bar and the second-stage pressure at 50 Bar. Circulate homogenize 3 times to obtain homogenized material. Transfer the homogenized material to a freeze dryer for freeze drying and sieve to obtain microencapsulated krill oil.

[0092] This embodiment also provides a method for preparing the aforementioned freeze-dried instant food for long-term administration of medication for chronic diseases in pets, including the following steps: (1) Preparation of disease-adapted freeze-dried staple food ① Raw material pretreatment: After preparing the raw materials according to the general disease support type freeze-dried staple food, cut them into particles with a particle size of 0.8cm; mix them evenly according to the weight parts to obtain a mixture.

[0093] ② Spreading and quick-freezing: Spread the mixture onto freeze-drying trays, controlling the thickness of the spread to 2cm, and then send it into a quick-freezing chamber for rapid freezing in an environment of -35℃, so that the core temperature of the material drops to below -18℃, and the frozen material is obtained.

[0094] ③ Vacuum freeze-drying: Transfer the quick-frozen material into the vacuum freeze-drying chamber, start the vacuum pump, maintain the vacuum level in the chamber at 50 Pa, and then dry in two stages: Primary drying (sublimation drying): The material temperature is raised from -35℃ to 0℃ at a heating rate of 7℃ / h, and then kept at that temperature for 12 hours to remove most of the free water.

[0095] Secondary drying (analytical drying): Continue heating to 30℃ and keep drying for 5 hours to remove bound water until the moisture content of the material is ≤5wt%, thus obtaining compound freeze-dried staple food.

[0096] ④ Discharge and Packaging: After freeze-drying, nitrogen gas is introduced into the vacuum freeze-drying chamber to break the air. In a dry environment with a relative humidity of ≤20%, the compound freeze-dried staple food is packed into aluminum foil bags and sealed with nitrogen.

[0097] (2) Preparation of drug administration auxiliary nutritional powder Add the raw materials required for the drug administration auxiliary nutritional powder to a three-dimensional motion mixer according to the weight proportions, mix for 30 minutes until uniformly mixed to obtain the drug administration auxiliary nutritional powder; package the drug administration auxiliary nutritional powder into aluminum foil bags and seal them.

[0098] (3) Finished product assembly By placing the relatively independently packaged disease-adapted freeze-dried staple food and the medication supplementary nutritional powder in the same outer packaging bag at a weight ratio of 10:1, a freeze-dried instant food for long-term administration of medication for pets with chronic diseases is produced.

[0099] This embodiment also provides the application of the freeze-dried instant food for long-term administration of medication for pets with chronic diseases. The freeze-dried food adapted to the disease, the medication supplementary nutritional powder and the medicine are mixed evenly in a weight ratio of 10:1:1. After adding twice the weight of drinking water and stirring for 50 seconds, the food is ready to be served to pets with chronic diseases.

[0100] Experimental Example 1 Twenty dogs and twenty cats with chronic diseases (such as chronic kidney disease, heart disease, thyroid dysfunction, epilepsy, etc.), requiring long-term daily medication, or with a history of drug refusal or difficulty in administration were selected. The dogs were divided into one group, and the cats into two groups. The experimental period was set at 28 days, including a baseline observation period of 1-7 days and an intervention period of 8-21 days.

[0101] During the baseline observation period of 1-7 days, each group received daily medication using the original method (direct administration or mixing with regular food). During the intervention period of 8-21 days, each group received medication using the disease-adapted freeze-dried staple food corresponding to this invention and the medication supplementary nutritional powder. Specifically, the disease-adapted freeze-dried staple food, medication supplementary nutritional powder, and medication were mixed evenly at a weight ratio of 10:1:1, and then twice the weight of drinking water was added and stirred for 30 seconds before being prepared and provided to pets with chronic diseases.

[0102] During the experiment, the success rate of drug administration, the total time for a single administration, the rate of proactive approach, and the owner's self-rating anxiety score (VAS) were recorded; the frequency of resistance behavior during the medication process was recorded; and statistical analysis was performed.

[0103] Among them, the drug administration success rate refers to the proportion of pets that voluntarily and completely ingest all the drug within 15 minutes in a single administration, out of the total number of pets in the group.

[0104] Total time for a single administration refers to the average time it takes for a pet to completely consume the medicated freeze-dried instant food in a single administration.

[0105] The active approach rate refers to the proportion of pets that actively approach the food bowl during a single administration of medication, out of the total number of pets in the group.

[0106] The owner's self-rating anxiety score refers to the VAS method used by owners to assess their anxiety level immediately after a single dose of medication, and to track changes in immediate anxiety after daily medication administration.

[0107] The frequency of resistance behavior refers to the proportion of pets exhibiting resistance behavior (such as hiding, head shaking, or vomiting) in a single dose out of the total number of pets in that group.

[0108] Statistical analysis refers to the process where experimental data are processed using Excel software, followed by analysis of variance using SPSS 16.0 statistical software. Results are expressed as mean ± standard deviation. Within-group comparisons of differences before and after intervention are performed using appropriate parametric or non-parametric tests. A p-value < 0.05 is used as the criterion for statistical significance.

[0109] The specific results are shown in the table below:

[0110] It can be seen that, compared with the baseline observation period, the cats and dogs in Group 1 and Group 2 showed statistically significant differences in each indicator during the intervention period (P < 0.05). The freeze-dried instant food of the present invention, which assists in the long-term administration of pets with chronic diseases, can effectively improve the success rate of administration to cats and dogs, significantly shorten the total time of a single administration, and the cats and dogs can actively approach the freeze-dried instant food containing the drug and rarely show resistance behavior. In addition, using the freeze-dried instant food of the present invention to assist in the administration of pets can significantly reduce the anxiety level of pet owners. The anxiety score measured by the VAS method after administration can be reduced from 8-8.5 points to 1.5-2.0 points, effectively reducing the psychological burden of long-term administration to pet owners.

[0111] Furthermore, on days 7 and 21 of the experiment, the alanine aminotransferase activity (ALT), creatinine (CREA), serum potassium, serum calcium, hematocrit, and white blood cell count of each dog in group 1 were measured, and the body condition BCS score of each dog was calculated. The average value was taken to evaluate the safety of the freeze-dried instant food of the present invention for dogs. The specific results are shown in the table below:

[0112] Furthermore, on days 7 and 21 of the experiment, the alanine aminotransferase activity (ALT), creatinine (CREA), serum potassium, serum calcium, hematocrit, and white blood cell count of each cat in the two groups were measured, and the body condition BCS scores of each cat were calculated and averaged to evaluate the safety of the freeze-dried instant food of the present invention for cats. Specific results are shown in the table below:

[0113] As can be seen, within the intervention period of the experiment, all indicators of the cats and dogs in each group were within the normal physiological fluctuation range, and their physical condition was good. Blood indicators showed that the liver and kidney functions of the cats and dogs in each group were normal, the freeze-dried instant food did not increase the metabolic burden on the liver and kidneys of the cats and dogs, and the immune system of the cats and dogs was stable without inflammation. At the same time, compared with day 7, there were no statistically significant differences in the indicators of alanine aminotransferase activity (ALT), creatinine (CREA), serum potassium, serum calcium, hematocrit, white blood cell count, and body condition BCS score in groups 1 and 2 on day 21 (P>0.05), indicating that long-term consumption of the freeze-dried instant food of the present invention did not increase the metabolic burden on the liver and kidneys, and the overall safety of the freeze-dried instant food of the present invention is good.

[0114] Unless otherwise stated, all percentages used in this invention are mass percentages.

[0115] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A freeze-dried instant food for long-term administration of medication to pets with chronic diseases, characterized in that, It includes independent disease-adapted freeze-dried staple food and drug-administered supplementary nutritional powder; the weight ratio of disease-adapted freeze-dried staple food to drug-administered supplementary nutritional powder is 10:

1. The disease-adapted freeze-dried staple food is one of the following: freeze-dried staple food for kidney disease support, freeze-dried staple food for heart disease support, and freeze-dried staple food for general diseases support. The freeze-dried staple food for kidney disease support includes the following ingredients: cod meat, chicken breast, egg white powder, and pumpkin powder; the weight ratio of cod meat, chicken breast, egg white powder, and pumpkin powder is 5:2:1:

1. The freeze-dried staple food for heart disease support includes the following ingredients: cod, chicken breast, egg white powder, and pumpkin powder; the weight ratio of cod, chicken breast, egg white powder, and pumpkin powder is 4:3:1:

1. The general disease support-type freeze-dried staple food includes the following ingredients: cod meat, chicken breast meat, egg white powder, pumpkin powder, and purple sweet potato powder; the weight ratio of cod meat, chicken breast meat, egg white powder, pumpkin powder, and purple sweet potato powder is 3:3:1:1:

1. The medication-aid nutritional powder includes the following ingredients: yeast extract, hydrolyzed pork liver powder, silica micro powder, xanthan gum, guar gum, α-casein hydrolysate, L-theanine, milk thistle extract, S-adenosylmethionine, and microencapsulated krill oil.

2. The freeze-dried instant food for long-term administration of medication for chronic diseases in pets according to claim 1, characterized in that, The medication-aid nutritional powder, by weight, consists of the following components: 15-16 parts yeast extract, 7-8 parts hydrolyzed pig liver powder, 1.9-2.3 parts silica micro powder, 1-1.2 parts xanthan gum, 1-1.2 parts guar gum, 1-1.2 parts α-casein hydrolysate, 0.5-0.7 parts L-theanine, 1.4-1.5 parts milk thistle extract, 0.7-0.9 parts S-adenosylmethionine, and 3-3.6 parts microencapsulated krill oil.

3. The freeze-dried instant food for long-term administration of medication for chronic diseases in pets according to claim 1, characterized in that, The preparation method of the microencapsulated krill oil includes the following steps: Step S1. Mix deionized water, sodium octenyl succinate starch, maltodextrin, whey protein, and sodium ascorbate evenly to obtain an aqueous solution; Step S2. Under stirring conditions, krill oil is added to the aqueous solution and sheared and emulsified to obtain a crude emulsion; Step S3. After high-pressure homogenization, the crude emulsion is freeze-dried to obtain microencapsulated krill oil.

4. The freeze-dried instant food for long-term administration of medication for chronic diseases in pets according to claim 3, characterized in that, In step S1, the weight ratio of deionized water, sodium octenyl succinate starch, maltodextrin, whey protein, and sodium ascorbate is 185-190:14.3-14.7:53-56:4.5-5.5:0.5-0.

6.

5. The freeze-dried instant food for long-term administration of medication for chronic diseases in pets according to claim 3, characterized in that, In step S2, the rate at which krill oil is added to the aqueous solution is 2-2.8 g / min; The rotation speed for shear emulsification is 10,000-12,000 rpm, and the shear emulsification time is 5-10 min; The mass ratio of the aqueous solution to krill oil is 10.2-10.3:

1.

6. The freeze-dried instant food for long-term administration of medication for chronic diseases in pets according to claim 3, characterized in that, In step S3, the high-pressure homogenization process controls the first-stage homogenization pressure to be 280-300 Bar and the second-stage pressure to be 40-50 Bar, and the homogenization is repeated 3 times.

7. A method for preparing freeze-dried instant food for long-term administration of medication for chronic diseases in pets as described in any one of claims 1-6, characterized in that, The process includes the following steps: preparing disease-adapted freeze-dried staple food and preparing drug-injection supplementary nutritional powder; The method for preparing disease-adapted freeze-dried staple food is as follows: the raw materials of the disease-adapted freeze-dried staple food are cut into granules, mixed evenly, and a mixture is obtained; the mixture is freeze-dried until the moisture content is ≤5wt% to obtain the disease-adapted freeze-dried staple food. The method for preparing the drug administration auxiliary nutritional powder is as follows: yeast extract, pig liver hydrolysate, silica micro powder, xanthan gum, guar gum, α-casein hydrolysate, L-theanine, milk thistle extract, S-adenosylmethionine, and microencapsulated krill oil are mixed evenly to obtain the drug administration auxiliary nutritional powder.

8. The application of a freeze-dried instant food for long-term administration of medication for chronic diseases in pets as described in any one of claims 1-6, characterized in that, Mix the disease-adapted freeze-dried staple food, medication supplementary nutritional powder, and medication evenly in a weight ratio of 10:1:1, then add drinking water and stir well before feeding it to your pet. The drug is either a powder or a liquid.

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