Traditional Chinese medicine composition for treating lung-spleen qi deficiency type allergic rhinitis and application thereof

Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating lung-spleen qi deficiency type allergic rhinitis and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials: 5 to 40 parts of radix astragali seu hedysari, 3 to 25 parts of radix rehmanniae, 3 to 20 parts of rhizoma atractylodis macrocephalae, 2 to 10 parts of herba ephedrae, 3 to 20 parts of rhizoma seu radix notopterygii, 3 to 15 parts of radix saposhnikoviae, 3 to 20 parts of cortex moutan, 3 to 15 parts of radix paeoniae rubra, 5 to 25 parts of radix cynanchi paniculati, 3 to 20 parts of bombyx batryticatus, 3 to 20 parts of cortex cercis chinensis, 3 to 20 parts of ramulus mori and 10 to 30 parts of oyster. The prescription is accurate in syndrome type and treats both symptoms and root causes. The comprehensive intervention system aiming at the complicated pathological network of allergic rhinitis is constructed through multi-target collaborative intervention and fusion of multiple pharmacological actions of enriching yin and tonifying qi, dispersing wind pathogen, activating blood and clearing damp, dispelling wind and dredging collaterals and the like. And the medicines are natural, so that the safety basis is good.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating nasal allergic rhinitis of the syndrome of deficiency of both the lung and spleen qi and its application. Background Art

[0002] Nasal allergic rhinitis refers to a nasal disease mainly characterized by recurrent nasal itching, sneezing, running clear nasal discharge accompanied by nasal congestion, which is equivalent to allergic rhinitis in modern medicine. "Qiu" (nasal congestion and running nose), as a traditional Chinese medicine syndrome, was first seen in "Monthly Ordinances" of "The Book of Rites": "If the summer climate prevails in late autumn, there will be floods in the country and the people will often have nasal congestion and sneezing." Liu Wansu in the Jin Dynasty explained the meaning of "qiu ti" in Volume 1 of "Original Patterns of Diseases in Plain Questions": "Qiu means a clear nasal discharge from the nose", "Ti means a sound made by a sudden expulsion of air from the nose due to itching." "Plain Questions: Treatise on the Correspondence between Yin and Yang and Manifestations": Therefore, if one does not exercise in winter, one will not get nasal congestion and epistaxis in spring. It was first pointed out that the opening of the pores leads to the invasion of wind-cold, causing nasal congestion and epistaxis. "General Treatise on the Causes and Symptoms of Diseases" in the Sui Dynasty, "Chapter 29: Syndromes of Nasal Diseases, Syndrome of Nasal Discharge" pointed out that "Phlegm, saliva, nasal discharge, when exposed to heat, will become dry, and when exposed to cold, will overflow and cannot be controlled. The lung qi communicates with the nose. If the lung is cold, the cold will enter the nose along with the qi, so that the nasal discharge cannot be controlled." It was first clearly pointed out that the deficiency of lung qi and the external attack of wind-cold are the internal and external causes of running clear nasal discharge. Zheng Meijian in the Qing Dynasty's "Medical Remarks in My Fan" said, "Infants with insufficient endowment will sneeze frequently every day. This is due to the weakness of the spleen and lung in the acquired constitution. The lung governs the skin and hair, and the spleen governs the muscles. Due to the loose skin, hair, and pores, it is easy to be invaded by external pathogens.... If the original endowment is insufficient and one is invaded by external pathogens, the middle qi will be weakened first and unable to control the external pathogens, so one must use the Buzhong Yiqi Decoction and the Liujun Decoction plus Bupleurum and Cimicifuga to nourish the yuan and relieve the symptoms", emphasizing the role of congenital endowment and acquired deficiency of the lung and spleen in the onset of sneezing and nasal congestion, and pointing out that tonifying the spleen and lung is the main principle for treating such diseases. Sun Yikui in "The Pearl of the Red Stream, Volume 3, Nasal Diseases" said, "In the west, the color is white, which communicates with the lung, has its opening in the nose, and stores essence in the lung.... The lung qi communicates with the nose. When the lung is in harmony, the nose can distinguish the smell of fragrance and odor. The so-called yang qi and zong qi are both the qi generated in the stomach. Although their names are different, their principles are the same. If due to hunger, fullness, fatigue, or overwork, the qi generated by the spleen and stomach is damaged, and when it is weak, the qi for transportation and operation cannot rise, and the pathogenic factors block the pores, so the nose is not unobstructed and cannot distinguish the smell of fragrance and odor. It is advisable to nourish the stomach, strengthen the nutritive qi, and let the yang qi and zong qi rise, then the nasal passage will be unobstructed." It emphasizes the role of the spleen and stomach functions in the occurrence and treatment of nasal diseases. To sum up, insufficient endowment and deficiency of the lung and spleen are the main internal causes of nasal allergic rhinitis, and the external invasion of wind pathogens is the main external cause. Tonifying the spleen and lung is the key in treatment.

[0003] In modern medicine, nasal congestion is highly correlated with allergic rhinitis. Its pathological mechanism is complex, currently believed to be mainly related to an imbalance in the differentiation of T lymphocytes (Th1 / Th2) and intrinsic lymphocytes (TLC2). This involves contact with and sensitization to allergens, inducing the production of inflammatory mediators such as mast cell degranulation, eosinophil infiltration, histamine, leukotrienes, cytokines such as IL-4 and IL-5, and the synthesis and release of neuropeptides such as SP. This leads to symptoms such as nasal itching, sneezing, runny nose, nasal congestion, and pale, edematous nasal mucosa when patients are stimulated (e.g., by contact with allergens, changes in temperature). This sensitivity to allergens and external stimuli such as temperature changes, caused by immune dysfunction, aligns well with the traditional Chinese medicine theory that "when the body's vital energy is abundant, pathogens cannot invade; where pathogens gather, the vital energy must be deficient." This disease has recurrent and sudden attacks with a prolonged course. It can induce sinusitis, nasal polyps, otitis media, asthma, etc. It is also an important cause of recurrent respiratory infections in children, which seriously affects the quality of life of patients. Moreover, the incidence rate of this disease is as high as 20-30%, and can be as high as 48% in some areas. It is more common in children.

[0004] Current Western medical treatments include immunotherapy (desensitization therapy), drug therapy (primarily nasal corticosteroids, nasal / oral antihistamines, and oral leukotriene inhibitors, with others including decongestants and M-receptor antagonists), and nasal nerve resection. However, problems remain, such as recurrent flare-ups requiring long-term medication, drug tolerance, and poor symptom control (e.g., persistent cough, runny nose, nasal congestion, and susceptibility to respiratory infections, especially in children). Side effects of medications (e.g., leukotriene inhibitors can cause mental health issues, and long-term use of corticosteroids may induce immune dysfunction) necessitate the exploration of new treatment methods. In recent years, monoclonal antibody therapy has emerged, but its usage guidelines and clinical efficacy are still under investigation, and whether long-term use will lead to "immune drift" remains to be observed. In contrast, Traditional Chinese Medicine (TCM), with its holistic regulation, multi-target intervention, and relatively fewer side effects, is increasingly showing its advantages in the treatment of chronic diseases. For rhinitis due to deficiency of lung and spleen qi, traditional Chinese medicine often uses the principle of "tonifying the lung and spleen, dispelling pathogens and clearing the nasal passages" to strengthen qi and consolidate the foundation, control the symptoms of rhinitis, and reduce the occurrence of rhinitis.

[0005] Based on this, the present invention is proposed. Summary of the Invention

[0006] The composition provided by this invention is based on accurate syndrome differentiation and offers a more targeted and innovative traditional Chinese medicine formula for treating rhinitis of the lung and spleen qi deficiency type.

[0007] This formula closely adheres to the pathogenesis of "deficiency of lung and spleen qi as the root cause, and external wind invasion as the manifestation." It employs Astragalus membranaceus, Rehmannia glutinosa, and Atractylodes macrocephala to tonify qi and nourish yin, thus strengthening the root cause by supporting yin and tonifying yang. It uses Notopterygium incisum, Ephedra sinica (honey-processed), and Saposhnikovia divaricata to dispel wind and clear the nasal passages, thus treating the manifestation. It is supplemented with Cercis chinensis bark, Paeonia suffruticosa bark, Paeonia lactiflora, Cynanchum paniculatum, Bombyx mori (fried), and Morus alba twigs to clear heat, promote diuresis, dispel wind, and unblock the channels, thus relieving the stagnation of pathogenic factors in the nasal passages and addressing the persistent and difficult-to-cure condition. Calcined oyster shell is added to astringe and consolidate, enhancing the root-strengthening effects of Astragalus membranaceus, Rehmannia glutinosa, and Atractylodes macrocephala, while also mitigating the potential harm to the body's vital energy caused by the dispersing and pungent nature of Notopterygium incisum, Ephedra sinica, and Saposhnikovia divaricata. This is the key difference between this formula and existing techniques, aiming to overcome the bottleneck in traditional Chinese medicine treatment of nasal congestion. This formula introduces the following key drugs to produce a synergistic effect:

[0008] 1. Prepared Astragalus, Rehmannia glutinosa, and Fried Atractylodes macrocephala: Prepared Astragalus (a product of Astragalus prepared with honey) is sweet and warm, and enters the lung and spleen meridians, with the function of tonifying the middle and replenishing qi. Rehmannia glutinosa (made from raw Rehmannia glutinosa through steaming and drying) is sweet and slightly warm, and enters the liver and kidney meridians, with the function of nourishing blood and yin, and replenishing essence and marrow. Fried Atractylodes macrocephala (processed Atractylodes macrocephala after being processed with honey and wheat bran) is sweet and bitter, and warm, with the function of strengthening the spleen and replenishing qi, and drying dampness. The three herbs combined nourish yin and replenish qi to strengthen the body's resistance and consolidate its foundation.

[0009] 2. Honey-processed Ephedra, Notopterygium Root, and Saposhnikovia Root: Honey-processed Ephedra (made from Ephedra processed with honey) is pungent, slightly bitter, and warm in nature. It enters the Lung and Bladder meridians and has the functions of inducing sweating to relieve exterior syndromes, clearing the lungs to relieve asthma, and promoting diuresis to reduce swelling. Notopterygium root is bitter, pungent, and warm in nature and enters the Bladder and Kidney meridians. It has the functions of relieving exterior syndromes, dispelling cold, eliminating wind and dampness, and relieving pain. Saposhnikovia root is pungent, sweet, and slightly warm in nature and enters the Bladder, Spleen, and Liver meridians. It has the functions of dispelling wind to relieve exterior syndromes, eliminating dampness and relieving pain, and stopping spasms. The three herbs combined have the functions of clearing the lungs to dispel wind and eliminate pathogens, eliminating dampness and relieving pain, targeting the symptoms of wind-evil invasion.

[0010] 3. Moutan bark and red peony root: Moutan bark is pungent and cool, entering the blood level, and has the effects of clearing heat, cooling blood, and promoting blood circulation, thus expelling pathogenic factors from the blood level. The effective components of moutan bark and Xu Changqing, such as paeonol, and the effective component of red peony root, paeoniflorin, have significant anti-allergic and immunomodulatory effects, directly addressing the key pathogenesis of wind-evil stagnation in the nasal cavity, which transforms into heat and burns the nasal collaterals.

[0011] 4. Bauhinia bark, Cynanchum paniculatum, stir-fried mulberry twigs, and stir-fried silkworm pupae: Bauhinia bark is pungent and neutral in nature, entering the liver meridian. It has the effects of promoting blood circulation, dispelling wind, promoting diuresis, and relieving pain. Cynanchum paniculatum is pungent and warm in nature, entering the liver and stomach meridians. It has the effects of dispelling wind, resolving dampness, relieving pain, and relieving itching. Stir-fried mulberry twigs (stir-fried mulberry twigs are the dried tender twigs of the mulberry tree, a plant in the Moraceae family, processed into a traditional Chinese medicine) are slightly bitter and neutral in nature, entering the liver meridian. They have the effect of dispelling wind and dampness and are a commonly used drug for treating rheumatic pain. Fried silkworm pupae (the dried body of the silkworm larvae infected with Beauveria bassiana, processed by stir-frying with wheat bran) has a pungent and salty taste and neutral properties. It enters the liver, lung, and stomach meridians, and has the effects of dispelling wind and relieving spasms, resolving phlegm and dissipating nodules. When combined with peony bark and red peony root, it has the effect of promoting blood circulation, dispelling wind and dampness, and enhancing the lung-clearing, wind-dispelling, and dampness-eliminating effects of honey-processed ephedra, notopterygium root, and saposhnikovia root. It targets the pathogenesis of nasal congestion caused by pathogenic factors stagnating in the nasal passages and internal dampness. Bauhinia bark, Cynanchum paniculatum, notopterygium root, and saposhnikovia root have strong analgesic effects, thus effectively inhibiting the sneezing reflex. Bauhinia bark, combined with Cynanchum paniculatum, fried mulberry twigs, and notopterygium root, can effectively control the inflammatory response of allergic rhinitis. The main component of Cynanchum paniculatum is paeonol, which has anti-allergic effects.

[0012] 5. Calcined Oyster Shell (Calcined oyster shell is a traditional Chinese medicine made by calcining oyster shells): Calcined oyster shell is salty in taste and slightly cold in nature. It enters the liver and kidney meridians, and has the functions of consolidating and astringing yin. When used in combination with ephedra, saposhnikovia, and notopterygium, it can restrain the disadvantages of its pungent and dispersing properties that may harm the body's vital energy. It can also help astragalus, stir-fried atractylodes macrocephala, and saposhnikovia to invigorate qi and consolidate the exterior.

[0013] Firstly, a traditional Chinese medicine composition for treating rhinitis due to deficiency of lung and spleen qi is prepared from the following raw materials in parts by weight:

[0014] Astragalus membranaceus 5-40 parts, Rehmannia glutinosa 3-25 parts, Atractylodes macrocephala 3-20 parts, Ephedra sinica 2-10 parts, Notopterygium incisum 3-20 parts, Saposhnikovia divaricata 3-15 parts, Paeonia suffruticosa 3-20 parts, Paeonia lactiflora 3-15 parts, Cynanchum paniculatum 5-25 parts, Bombyx mori 3-20 parts, Cercis chinensis bark 3-20 parts, Morus alba twig 3-20 parts, Ostrea gigas 10-30 parts.

[0015] A further improvement is made to the traditional Chinese medicine composition for treating rhinitis due to lung and spleen deficiency, which is prepared from the following raw materials in parts by weight:

[0016] Prepared Astragalus membranaceus 5-40 parts, Rehmannia glutinosa 3-25 parts, stir-fried Atractylodes macrocephala 3-20 parts, honey-processed Ephedra sinica 2-10 parts, Notopterygium incisum 3-20 parts, Saposhnikovia divaricata 3-15 parts, Paeonia suffruticosa 3-20 parts, Paeonia lactiflora 3-15 parts, Cynanchum paniculatum 5-25 parts, stir-fried Bombyx mori 3-20 parts, Cercis chinensis bark 3-20 parts, stir-fried Morus alba twigs 3-20 parts, calcined Ostrea gigas 10-30 parts.

[0017] A further improvement is made to the traditional Chinese medicine composition for treating rhinitis due to lung and spleen deficiency, which is prepared from the following raw materials in parts by weight:

[0018] 15 parts of roasted Astragalus membranaceus, 12 parts of prepared Rehmannia glutinosa, 12 parts of stir-fried Atractylodes macrocephala, 9 parts of honey-processed Ephedra sinica, 12 parts of Notopterygium incisum, 10 parts of Saposhnikovia divaricata, 15 parts of Paeonia suffruticosa, 12 parts of Paeonia lactiflora, 20 parts of Cynanchum paniculatum, 12 parts of stir-fried Bombyx mori, 15 parts of Cercis chinensis bark, 12 parts of stir-fried Morus alba twigs, and 20 parts of calcined Ostrea gigas.

[0019] A further improvement is that the traditional Chinese medicine composition for treating rhinitis due to deficiency of lung and spleen qi also includes pharmaceutically acceptable excipients.

[0020] In a further improvement, the traditional Chinese medicine composition for treating rhinitis due to deficiency of lung and spleen qi includes pharmaceutically acceptable carriers, diluents, and excipients.

[0021] Secondly, a method for preparing a traditional Chinese medicine composition for treating rhinitis due to lung and spleen qi deficiency includes the following steps:

[0022] Step 1: Weigh out the following ingredients in order according to the formula: Astragalus membranaceus, Rehmannia glutinosa, Atractylodes macrocephala, Ephedra sinica, Notopterygium incisum, Saposhnikovia divaricata, Paeonia suffruticosa, Paeonia lactiflora, Cynanchum paniculatum, Bombyx mori, Cercis chinensis bark, Morus alba twigs, and Ostrea gigas, and calculate the total weight of the above ingredients.

[0023] Step 2: Add water to all the above ingredients and boil them down. Filter the decoction to obtain the Chinese medicine decoction.

[0024] Further improvements include concentrating, spray-drying, and granulating traditional Chinese medicine decoctions to produce traditional Chinese medicine granules.

[0025] Further improvements include concentrating, spray-drying, granulating, and compressing traditional Chinese medicine decoctions into tablets.

[0026] Further improvements involve concentrating, spray-drying, granulating, and filling capsule shells with traditional Chinese medicine decoctions to produce traditional Chinese medicine capsules.

[0027] Thirdly, the application of the traditional Chinese medicine composition for treating rhinitis due to lung and spleen deficiency in the preparation of drugs for treating rhinitis due to lung and spleen deficiency.

[0028] Compared with the prior art, the beneficial effects of this invention are as follows:

[0029] This formula accurately identifies the syndrome type (lung and spleen qi deficiency) and treats both the root cause and symptoms (nourishing yin and replenishing qi to strengthen the body's resistance, and dispelling pathogenic factors and clearing the orifices to treat the symptoms). Through multi-target synergistic intervention, it integrates multiple pharmacological effects such as nourishing yin and replenishing qi, dispelling wind-evil, promoting blood circulation and removing dampness, and dispelling wind and clearing the meridians, constructing a comprehensive intervention system targeting the complex pathological network of nasal congestion. The medicines are derived from natural sources and have a good safety profile. Attached Figure Description

[0030] Figure 1 This is a flowchart of the establishment and drug administration process for an animal model of allergic rhinitis.

[0031] Figure 2 These are images recorded from mouse behavior.

[0032] Figure 3 The effects of the traditional Chinese medicine composition of this invention on behavioral indicators in mice;

[0033] Figure 4 The effect of traditional Chinese medicine composition on the serum inflammatory factor secretion levels of mice in each group;

[0034] Figure 5 The pathological findings of the nasal mucosa in AR mice are presented. Detailed Implementation

[0035] The present invention will now be described in further detail with reference to specific embodiments and accompanying drawings.

[0036] Example 1

[0037] Formula 1:

[0038] Prepared Astragalus membranaceus 15g, Rehmannia glutinosa 12g, Atractylodes macrocephala 12g, Ephedra sinica 9g, Notopterygium incisum 12g, Saposhnikovia divaricata 10g, Paeonia suffruticosa 15g, Paeonia lactiflora 12g, Cynanchum paniculatum 20g, Bombyx mori 12g, Cercis chinensis 15g, Morus alba 12g, Calcined Ostrea gigas 20g.

[0039] Method of decoction:

[0040] Place all the above ingredients into a decoction bag, add 2500g of water, and soak for 30 minutes; then heat to 100℃ in a decoction machine, decoct for 2 hours and concentrate; after decoction, filter to obtain 170ml of Chinese herbal decoction.

[0041] The properties of the traditional Chinese medicine composition (traditional Chinese medicine decoction) obtained in Example 1 will be described from the following aspects.

[0042] I. Characterization Experiment

[0043] 1. Experimental Methods

[0044] 1.1 Animal modeling, grouping, and drug administration

[0045] Mice were divided into six groups according to body weight after one week of acclimatization: Control group, Model group, Loratadine (P) group, Low-dose (TL) group, Medium-dose (TM) group, and High-dose (TH) group of the traditional Chinese medicine preparation of this invention, with 20 mice in each group. The first two weeks were the basal sensitization phase: a saline suspension containing 3% aluminum hydroxide was prepared, and ovalbumin (OVA) was dissolved in this suspension at a concentration of 10 mg / mL. Except for the control group, mice in all other groups were intraperitoneally injected with 0.1 mL of OVA-aluminum hydroxide suspension (containing 1 mg OVA) every other day for a total of 7 times; the control group was injected with an equal volume of saline. OVA was dissolved in saline at a concentration of 50 mg / mL. From day 21, except for the control group, mice in each group were instilled with 10 μL of OVA solution (total dose 1 mg / day) into each nostril daily for 7 consecutive days; the control group was instilled with an equal volume of saline. The success of establishing the allergic rhinitis model was assessed using behavioral indicators (such as nose scratching and sneezing frequency). Administration of medication continued for 14 days, starting from day 15 of the sensitization phase. The loratadine group received a clinically equivalent dose of loratadine via gavage. The TL, TM, and TH groups received 11, 22, and 44 g / kg / day of the traditional Chinese medicine decoction prepared in Example 1, respectively, via gavage. The control and model groups received the same volume of ultrapure water via gavage (key experimental steps and time points are detailed in [link to relevant documentation]). Figure 1 。 ).

[0046] 1.2 Detection Indicators

[0047] 1.2.1 Behavioral Evaluation

[0048] During the induction phase, a video recording system was used to observe behavioral changes in mice: Before each experiment, mice were placed in a transparent cylinder for 15-20 minutes to acclimatize, followed by nasal provocation, and immediately returned to the same cylinder for continuous recording for 15 minutes. During the recording period, the number of times each mouse scratched its nose, the frequency of sneezing, and the degree of runny nose were recorded. Figure 2 ).

[0049] 1.2.2 ELISA method for detecting serum-related indicators

[0050] After the final behavioral observation, blood was collected by enucleation. The whole blood was allowed to stand for 2 hours, then centrifuged to separate the serum, which was stored at -80℃ for later use. Subsequently, the levels of immunoglobulin E (IgE), histamine (HA), and interleukin-6 (IL-6) in the serum were measured strictly according to the ELISA kit instructions.

[0051] 1.2.3 HE staining of nasal mucosa tissue

[0052] Mouse nasal mucosa tissue was collected and fixed in 4% paraformaldehyde for 48 h. After decalcification and trimming, the tissue was dehydrated with graded ethanol and then embedded in paraffin. The embedded tissue was sectioned at a thickness of 4 μm, stained with hematoxylin and eosin (HE), and observed under a microscope for pathological morphological changes in the nasal mucosa.

[0053] 1.2.4 Statistical Methods

[0054] All data were analyzed using GraphPad Prism 8.0 software, and results are expressed as mean ± standard deviation (Mean ± SD). If the data from each group conformed to a normal distribution, one-way ANOVA was used for overall comparisons; if the variances were homogeneous, the LSD test was used for pairwise comparisons between groups; if the variances were unequal, Dunnett's test was used for comparisons between groups. If any data group did not conform to a normal distribution, nonparametric tests were used for statistical analysis.

[0055] 2 Results

[0056] 2.1 Effects of each drug administration group on the behavioral scores of mice

[0057] according to Figure 3 As a result, compared with the control group, the model group mice showed a significant increase in nose-scratching, sneezing, and runny nose behaviors. However, compared with the model group, the nose-scratching and sneezing symptoms in each treatment group were alleviated to varying degrees, indicating that the traditional Chinese medicine preparation of this invention can effectively reduce allergic rhinitis symptoms in mice.

[0058] exist Figure 3 Compared with the control group, ###P<0.001; compared with the model group, *P<0.05, **P<0.01, ***P<0.001.

[0059] 2.2 Effects of each drug administration group on relevant serum indicators in mice

[0060] according to Figure 4 As a result, compared with the control group, the serum levels of IgE, HA, and IL-6 in the model group mice were significantly increased. Compared with the model group, the serum levels of the above indicators (IgE, HA, and IL-6) in each treatment group mice were decreased to varying degrees, indicating that the traditional Chinese medicine preparation of this invention can effectively inhibit the release of related inflammatory mediators and alleviate allergic reactions and the degree of inflammation.

[0061] Figure 4 Compared with the control group, ##P<0.01, ###P<0.001; compared with the model group, *P<0.05, ***P<0.001.

[0062] 2.3 Effects of each drug administration group on histopathological changes of mouse nasal mucosa

[0063] Figure 5 The pathological observation results of the nasal mucosa of AR mice are presented. In the control group, the nasal mucosa of mice was structurally intact, with a surface composed of regularly arranged, continuous pseudostratified ciliated columnar epithelium, showing no obvious damage. In the model group, the nasal mucosa of mice exhibited impaired integrity, disordered ciliary arrangement, and signs of mucosal injury. Compared with the model group, the structural integrity of the nasal mucosa in each treatment group was improved to varying degrees, and inflammatory cell infiltration was reduced.

[0064] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine composition for treating rhinitis due to deficiency of lung and spleen qi, characterized in that, It is prepared from the following raw materials in parts by weight: Astragalus membranaceus 5-40 parts, Rehmannia glutinosa 3-25 parts, Atractylodes macrocephala 3-20 parts, Ephedra sinica 2-10 parts, Notopterygium incisum 3-20 parts, Saposhnikovia divaricata 3-15 parts, Paeonia suffruticosa 3-20 parts, Paeonia lactiflora 3-15 parts, Cynanchum paniculatum 5-25 parts, Bombyx mori 3-20 parts, Cercis chinensis bark 3-20 parts, Morus alba twig 3-20 parts, Ostrea gigas 10-30 parts.

2. The traditional Chinese medicine composition for treating rhinitis of the lung and spleen qi deficiency type according to claim 1, characterized in that, It is prepared from the following raw materials in parts by weight: Prepared Astragalus membranaceus 5-40 parts, Rehmannia glutinosa 3-25 parts, stir-fried Atractylodes macrocephala 3-20 parts, honey-processed Ephedra sinica 2-10 parts, Notopterygium incisum 3-20 parts, Saposhnikovia divaricata 3-15 parts, Paeonia suffruticosa 3-20 parts, Paeonia lactiflora 3-15 parts, Cynanchum paniculatum 5-25 parts, stir-fried Bombyx mori 3-20 parts, Cercis chinensis bark 3-20 parts, stir-fried Morus alba twigs 3-20 parts, calcined Ostrea gigas 10-30 parts.

3. The traditional Chinese medicine composition for treating rhinitis of the lung and spleen qi deficiency type according to claim 2, characterized in that, It is prepared from the following raw materials in parts by weight: 15 parts of roasted Astragalus membranaceus, 12 parts of prepared Rehmannia glutinosa, 12 parts of stir-fried Atractylodes macrocephala, 9 parts of honey-processed Ephedra sinica, 12 parts of Notopterygium incisum, 10 parts of Saposhnikovia divaricata, 15 parts of Paeonia suffruticosa, 12 parts of Paeonia lactiflora, 20 parts of Cynanchum paniculatum, 12 parts of stir-fried Bombyx mori, 15 parts of Cercis chinensis bark, 12 parts of stir-fried Morus alba twigs, and 20 parts of calcined Ostrea gigas.

4. The traditional Chinese medicine composition for treating rhinitis of the lung and spleen qi deficiency type according to claim 1, characterized in that: It also includes pharmaceutically acceptable excipients.

5. The traditional Chinese medicine composition for treating rhinitis of the lung and spleen qi deficiency type according to claim 4, characterized in that: The pharmaceutical excipients are pharmaceutically acceptable carriers, diluents, and excipients.

6. A method for preparing a traditional Chinese medicine composition for treating rhinitis of the lung and spleen qi deficiency type as described in any one of claims 1 to 5, characterized in that, Includes the following steps: Step 1: Weigh out the following ingredients in order according to the formula: Astragalus membranaceus, Rehmannia glutinosa, Atractylodes macrocephala, Ephedra sinica, Notopterygium incisum, Saposhnikovia divaricata, Paeonia suffruticosa, Paeonia lactiflora, Cynanchum paniculatum, Bombyx mori, Cercis chinensis bark, Morus alba twigs, and Ostrea gigas, and calculate the total weight of the above ingredients. Step 2: Add water to all the above ingredients and boil them down. Filter the decoction to obtain the Chinese medicine decoction.

7. The method for preparing a traditional Chinese medicine composition for treating rhinitis of the lung and spleen qi deficiency type according to claim 6, characterized in that: Traditional Chinese medicine decoctions are concentrated, spray-dried, and granulated to produce traditional Chinese medicine granules.

8. The method for preparing a traditional Chinese medicine composition for treating rhinitis of the lung and spleen qi deficiency type according to claim 6, characterized in that: Traditional Chinese medicine decoctions are concentrated, spray-dried, granulated, and compressed into tablets.

9. A method for preparing a traditional Chinese medicine composition for treating rhinitis of the lung and spleen qi deficiency type according to claim 6, characterized in that: Traditional Chinese medicine decoctions are concentrated, spray-dried, granulated, and filled into capsule shells to produce traditional Chinese medicine capsules.

10. The use of any one of the traditional Chinese medicine compositions for treating rhinitis due to lung and spleen deficiency in the preparation of a medicine for treating rhinitis due to lung and spleen deficiency.

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