Cell aggregate recycling system

By designing a movable or fixed tilting extension grading system, the problem of long cell aggregate removal time in existing technologies has been solved, achieving rapid grading and efficient recycling, thereby improving productivity and cell quality.

CN122095075APending Publication Date: 2026-05-26NIKKISO CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-02-06
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing technologies, when using suction tubes to remove cell aggregates from culture containers, result in long removal times, impacting productivity and cell quality, and making rapid grading difficult.

Method used

A grading system was designed, including a culture section and a grading section. The grading section includes a movable or fixed tilted extension, which enables rapid grading and recovery of cell aggregates by adjusting the tilt angle and flow mode.

Benefits of technology

Rapid grading and efficient recycling of cell aggregates were achieved while maintaining a sealed state, improving production efficiency and maintaining cell quality.

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Abstract

This disclosure provides a grading system capable of grading cell aggregates of a desired size from a culture vessel in a short time while maintaining a sealed state. The grading system comprises: a culture section containing fluid comprising cell aggregates; and a grading section that grades the cell aggregates into first cell aggregates having a diameter less than a predetermined diameter and second cell aggregates having a diameter greater than or equal to the predetermined diameter, the grading section including an extension for fluid to flow along the extension direction, and the extension being either a movable extension in an inclined state at least partially inclined relative to the vertical direction or a fixed extension in an inclined state.
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Citation Information

Patent Citations

  • Semiconductor laser unit

    JP2024018123A

  • Culture device and culture method

    WO2023013485A1