Production of high plasticity stem cells

By isolating and activating dormant guide cells from adult tissues to generate highly plastic stem cells (giaSC), the ethical and tumorigenicity issues of existing stem cell therapies are resolved, achieving highly efficient tissue regeneration and therapeutic effects.

CN122095076APending Publication Date: 2026-05-26APSTEM THERAPEUTICS INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-10-04
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing stem cell therapies face challenges such as ethical issues, tumorigenicity, and low yield, failing to provide highly plastic adult stem cells for the treatment of tissue damage and degenerative diseases.

Method used

Dormant guide cells with a diameter of less than 6 micrometers are isolated from adult tissues, activated, and brought into contact with somatic cells to generate highly plastic stem cells (giaSCs) through cell-cell interactions. These cells have transgerm layer differentiation potential and are non-tumorigenic.

Benefits of technology

The generated giaSC can be expanded in vitro and can adapt to the host environment in vivo, actively regenerating and reconstructing tissues, solving the ethical and tumorigenicity issues of existing stem cell therapies and providing a highly efficient treatment option.

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Abstract

A population of minute dormant cells is isolated from adult tissue that exhibit unique properties after activation and growth in vitro, referred to herein as pilot cells, different from all known cell types. The guided cells can interact with somatic cells to produce a novel high-plasticity stem cell, referred to herein as guided integrated adult stem cells (giaSC). Thus, cell populations and compositions having high plasticity stem cells or guide cells, as well as methods of producing such cell populations and compositions, are provided. Also provided are methods of modulating somatic cells by interacting with guide cells or cellular components thereof. The compositions and methods are useful for a variety of therapeutic purposes.
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Citation Information

Patent Citations

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