A medical disposable integrated fluid path system

Abstract

The application provides a medical disposable integrated liquid path system, which comprises a plurality of sequentially connected bases and filters connected to the bases; the base is provided with an inlet channel and an outlet channel, and the outlet channel and the inlet channel on adjacent bases are communicated; the filter is provided with an inlet port and an outlet port, and the filter is clamped on the base so as to communicate the inlet channel and the inlet port and communicate the outlet port and the outlet channel. The modular design of the base and the filter and the integrated installation simplify the construction process, are quick to install, integrate the miscellaneous pipelines into the base, reduce the loss of filtered medicinal liquid, reduce the floor area, after assembly, there is only one inlet channel and one outlet channel, and there is no additional pipeline, so that the structure is simple, the relationship between the multi-stage filters is clear and concise, and the pipeline installation error is avoided.

Description

Technical Field

[0001] This invention relates to the field of filtration technology, and more particularly to a disposable integrated liquid circuit system for pharmaceutical use. Background Technology

[0002] In the biopharmaceutical field, multi-stage filtration is often used in production. This method requires segmented assembly and involves various filter interface shapes and sizes. The following problems are often encountered during the production process:

[0003] 1. Poor sealing at the interface and difficulty in cleaning pose a high risk of cross-contamination: Multi-stage filtration requires the splicing of multiple filters, and leaks at the joints can easily occur, potentially exposing the product to air. This could cause deformation in some easily reversible products, affecting product quality. Furthermore, the joints have many dead corners, making it easier for materials to remain, and thorough cleaning and sterilization are difficult, easily leading to cross-contamination between multiple production batches.

[0004] 2. Poor adaptability and compatibility, cumbersome operation: Multi-stage filtration requires splicing multiple filters, each with different area and interface, thus requiring the configuration of multiple interfaces, adapters and pipelines. In actual production, the operation is cumbersome, and the adaptability and compatibility are poor.

[0005] In the 1950s, the concept of disposable integrated fluid systems was initially established, mainly consisting of single pipelines and simple connectors, without the formation of integrated designs. In recent years, with the rapid development of the biopharmaceutical field, its application scenarios have extended to the fields of refined and high-end production. However, the internal connection methods of existing disposable integrated fluid systems are still insufficient and cannot fully meet the increasingly complex process requirements and large-scale production needs. There is still considerable room for improvement in terms of connection reliability, ease of operation, and overall system compatibility.

[0006] The aforementioned problems are particularly prominent in the sample preparation stage. This is because, in sample preparation processes where multiple filters are used simultaneously, the different interfaces of each filter necessitate the use of multiple pipelines and adapters for connection, making the process cumbersome and prone to causing confusion. For example:

[0007] 1. The preparation site is messy and the pipeline connection is prone to errors: the connection of filters with different interfaces requires a variety of adapters and corresponding pipelines, which takes up a lot of desktop space in the laboratory; and the pipeline connection requires careful checking of the flow path direction, which is time-consuming, labor-intensive and prone to errors.

[0008] 2. The entire pipeline system has a large residual volume: In the experimental preparation stage, every milliliter of drug solution is hard-won. Any liquid remaining in the experimental pipeline will at least waste experimental resources, and at worst affect the experimental results.

[0009] 3. Installation difficulties: During the experimental preparation stage, the various components used come from different manufacturers with different interfaces. Different interfaces correspond to different bases, requiring various adapters and installation tools, making the setup of the device quite difficult.

[0010] While some manufacturers in the industry currently offer complete solutions, these solutions are still simply interconnections between different interfaces and devices, failing to truly solve the above problems. Summary of the Invention

[0011] The purpose of this invention is to disclose a disposable integrated liquid circuit system for pharmaceuticals, which features a modular design and integrated installation of the base and filter, simplifying the setup process and enabling quick installation. By integrating redundant piping into the base, the loss of filtered liquid is reduced, and the floor space is minimized. After assembly, there is only one inlet channel and one outlet channel, with no additional piping. The simple structure makes the relationship between multiple filtration stages clear and concise, and eliminates the possibility of incorrect piping installation.

[0012] To achieve the above objectives, the present invention discloses a disposable integrated liquid circuit system for pharmaceutical use, comprising a plurality of bases connected in sequence and a filter connected to the base; the base is provided with an inlet channel and an outlet channel, and the outlet channel and inlet channel on adjacent bases are connected; the filter is provided with an inlet port and an outlet port, and the filter is snapped onto the base so that the inlet channel and inlet port are connected, and the outlet port and outlet channel are connected.

[0013] In some embodiments, the base is provided with a liquid outlet pipe with a protruding surface, the liquid outlet channel is located in the liquid outlet pipe, and the liquid outlet pipe on the adjacent base is inserted into the liquid inlet channel.

[0014] In some embodiments, a sealing gasket is also included, which is connected within the liquid inlet channel, and an outlet pipe on an adjacent base is inserted into the liquid inlet channel and abuts against the sealing gasket.

[0015] In some embodiments, the base has buckles at both ends, and the filter has buckle notches at both ends, with the buckles engaging in the buckle notches.

[0016] In some embodiments, the filter surface is provided with positioning protrusions, and the base is provided with corresponding positioning grooves.

[0017] In some embodiments, the inlet channel is connected to an inlet tube, which is inserted into the inlet port, and the outlet channel is connected to an outlet tube, which is inserted into the outlet port.

[0018] In some embodiments, the base includes parallel bases and series bases.

[0019] In some embodiments, the parallel base is provided with two filters, and the parallel base is also provided with a first connecting channel, a second connecting channel, two liquid inlet tubes, and two liquid outlet tubes. The liquid inlet channel and the two liquid inlet tubes on the parallel base are connected through the first connecting channel, and the liquid outlet channel and the two liquid outlet tubes on the parallel base are connected through the second connecting channel.

[0020] In some embodiments, a filter is provided on the series base.

[0021] In some embodiments, the filter has a filtration accuracy of 0.1 micrometers to 10 micrometers.

[0022] Compared with the prior art, the beneficial effects of the present invention are: the modular design and integrated installation of the base and filter simplify the construction process and make installation quick; the integration of redundant pipelines into the base reduces the loss of filter solution and reduces the floor space; after assembly, there is only one inlet channel and one outlet channel, without any additional pipelines, and the structure is simple, making the relationship between multi-stage filtration clear and concise, and eliminating the possibility of pipeline installation errors. Attached Figure Description

[0023] Figure 1 This is a perspective view of a disposable integrated fluid circuit system for pharmaceutical use according to the present invention;

[0024] Figure 2 for Figure 1 The front view;

[0025] Figure 3 for Figure 2 The AA section view shown;

[0026] Figure 4 for Figure 1 The front view of the series base shown;

[0027] Figure 5 for Figure 4 The CC section view shown;

[0028] Figure 6 for Figure 1 A top view of the tandem base shown;

[0029] Figure 7 for Figure 5 The diagram shows the structure of the sealing gasket.

[0030] Figure 8 for Figure 1 The structural diagram of the parallel base shown;

[0031] Figure 9 for Figure 1A top view of the parallel base shown;

[0032] Figure 10 for Figure 1 The diagram shows the structure of the filter. Detailed Implementation

[0033] The present invention will now be described in detail with reference to the embodiments shown in the accompanying drawings. However, it should be noted that these embodiments are not intended to limit the present invention. Any equivalent substitutions or replacements in function, method, or structure made by those skilled in the art based on these embodiments are within the scope of protection of the present invention.

[0034] like Figure 1-10 The illustrated disposable integrated fluid circuit system for pharmaceutical use includes several bases connected in sequence and a filter 3 connected to the base.

[0035] The base includes parallel bases 2 and series bases 1. Series bases 1 enable multi-stage filtration, while parallel bases 2 enable a larger processing capacity. Depending on the actual situation, an appropriate number of parallel bases 2 and series bases 1 can be selected for combination.

[0036] The series base 1 has one filter 3, and the parallel base 2 has two filters 3. The filtration accuracy of the filters 3 is from 0.1 micrometers to 10 micrometers. Filters 3 with appropriate filtration accuracy can be installed on the parallel base 2 and the series base 1 according to actual needs.

[0037] The filter 3 is provided with an inlet port 31 and an outlet port 32. Liquid enters from the inlet port 31 and is discharged from the outlet port 32 after filtration.

[0038] The series base 1 is provided with an inlet channel 11 and an outlet channel 13. The inlet channel 11 is connected to an inlet tube 111, which is inserted into the inlet port 31. The outlet channel 13 is connected to an outlet tube 131, which is inserted into the outlet port 32. The connection is tight, allowing the liquid in the inlet channel 11 to enter the inlet port 31 and the liquid discharged from the outlet port 32 to enter the outlet channel 13, thereby completing one filtration of the liquid.

[0039] The series base 1 is provided with a liquid outlet pipe 14 with a protruding surface, and the liquid outlet channel 13 is located in the liquid outlet pipe 14. It also includes a sealing gasket 12, which is connected in the liquid inlet channel 11 and serves as a seal.

[0040] The filter 3 is snapped onto the series base 1 so that the inlet tube 111 is inserted into the inlet port 31 and the outlet tube 131 is inserted into the outlet port 32. Specifically, the series base 1 has buckles 15 at both ends, and the filter 3 has buckle notches 33 at both ends. The buckles 15 are snapped into the buckle notches 33, realizing the connection between the filter 3 and the series base 1. The connection is firm, eliminating the need for external pipes, reducing the footprint, and making the filter installation faster and more convenient. The surface of the filter 3 has positioning protrusions 34, and the series base 1 has corresponding positioning grooves 16, which serve as guides and positions.

[0041] The parallel base 2 is equipped with two filters 3. The parallel base 2 is equipped with an inlet channel 21, an outlet channel 23, a first connecting channel 27, a second connecting channel 28, two inlet tubes 211, and two outlet tubes 231. The inlet channel 21 and the two inlet tubes 211 are connected by the first connecting channel 27, and the outlet channel 23 and the two outlet tubes 231 are connected by the second connecting channel 28.

[0042] The inlet tube 211 is inserted into the inlet port 31, and the outlet tube 231 is inserted into the outlet port 32, with a tight connection. Liquid enters through the inlet channel 21, enters the inlet ports 31 of the two filters 3 through the first connecting channel 27, and after filtration, the liquid is discharged from the outlet ports 32 of the two filters 3 into the second connecting channel 28, and finally discharged through the outlet channel 23, thus completing one filtration.

[0043] The parallel base 2 is provided with a liquid outlet pipe 24 with a protruding surface, and the liquid outlet channel 23 is located in the liquid outlet pipe 24. It also includes a sealing gasket 22, which is connected in the liquid inlet channel 21 and serves as a seal.

[0044] The filter 3 is snapped onto the parallel base 2. Specifically, the parallel base 2 has buckles 25 at both ends, and the filter 3 has buckle notches 33 at both ends. The buckles 25 engage with the buckle notches 33, thus connecting the filter 3 and the parallel base 2 securely. This eliminates the need for external piping, reduces space requirements, and makes filter installation quicker and more convenient. The surface of the filter 3 has positioning protrusions 34, and the parallel base 2 has corresponding positioning grooves 26, which serve as guides and positions the filter.

[0045] When two series-connected bases 1 are connected, the outlet pipe 14 on the adjacent series-connected base 1 is inserted into the inlet channel 11 and abuts against the sealing gasket 12. When the series-connected base 1 and the parallel-connected base 2 are connected, the outlet pipe 24 on the parallel-connected base 2 is inserted into the inlet channel 11 of the series-connected base 1 and abuts against the sealing gasket 12, or the outlet pipe 14 on the series-connected base 1 is inserted into the inlet channel 21 of the parallel-connected base 2 and abuts against the sealing gasket 22.

[0046] After the series base 1 and parallel base 2 are assembled, there is only one inlet channel and one outlet channel, with no additional pipes. The simple structure makes the relationship between the multi-stage filtration clear and concise, eliminating the possibility of incorrect pipe installation. The modular design and integrated installation reduce the footprint of the filtration unit, simplify the assembly process, and make installation quick. By integrating complex piping into the base, the loss of filter media is reduced.

[0047] The detailed descriptions listed above are merely specific descriptions of feasible embodiments of the present invention, and are not intended to limit the scope of protection of the present invention. All equivalent embodiments or modifications made without departing from the spirit of the present invention should be included within the scope of protection of the present invention.

[0048] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A disposable integrated fluid circuit system for pharmaceutical use, characterized in that, It includes several bases connected in sequence and a filter connected to the base; the base is provided with an inlet channel and an outlet channel, and the outlet channel and inlet channel of adjacent bases are connected; the filter is provided with an inlet port and an outlet port, and the filter is snapped onto the base so that the inlet channel and inlet port are connected, and the outlet port and outlet channel are connected.

2. The disposable integrated fluid circuit system for pharmaceutical use according to claim 1, characterized in that, The base is provided with a liquid outlet pipe with a protruding surface, and the liquid outlet channel is located in the liquid outlet pipe. The liquid outlet pipes on the adjacent base are inserted into the liquid inlet channel.

3. The disposable integrated fluid circuit system for pharmaceutical use according to claim 2, characterized in that, It also includes a sealing gasket, which is connected in the liquid inlet channel, and the liquid outlet pipe on the adjacent base is inserted into the liquid inlet channel and abuts against the sealing gasket.

4. The disposable integrated fluid circuit system for pharmaceutical use according to claim 1, characterized in that, The base has buckles at both ends, and the filter has buckle notches at both ends, with the buckles engaging in the buckle notches.

5. The disposable integrated fluid circuit system for pharmaceutical use according to claim 4, characterized in that, The filter surface is provided with positioning protrusions, and the base is provided with corresponding positioning grooves.

6. The disposable integrated fluid circuit system for pharmaceutical use according to claim 1, characterized in that, The inlet channel is connected to an inlet tube, which is inserted into the inlet port. The outlet channel is connected to an outlet tube, which is inserted into the outlet port.

7. The disposable integrated fluid circuit system for pharmaceutical use according to claim 6, characterized in that, The base includes parallel bases and series bases.

8. The disposable integrated fluid circuit system for pharmaceutical use according to claim 7, characterized in that, The parallel base is equipped with two filters, a first connecting channel, a second connecting channel, two inlet tubes, and two outlet tubes. The inlet channel and the two inlet tubes on the parallel base are connected through the first connecting channel, and the outlet channel and the two outlet tubes on the parallel base are connected through the second connecting channel.

9. The disposable integrated fluid circuit system for pharmaceutical use according to claim 7, characterized in that, A filter is provided on the series base.

10. The disposable integrated fluid circuit system for pharmaceutical use according to claim 1, characterized in that, The filter has a filtration accuracy of 0.1 micrometers to 10 micrometers.

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