A water-soluble achiral rare earth tetrahedral cage CPL probe for recognition of sulfhydryl amino acids and a preparation method thereof

CN122102877APending Publication Date: 2026-05-29HEILONGJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HEILONGJIANG UNIV
Filing Date
2026-03-19
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

Existing optical probes have poor biocompatibility and adaptability in biological systems, and their detection performance is insufficient. In particular, they are difficult to accurately distinguish between thiol amino acids and non-thiol amino acids in high-salt, pH fluctuating, and multi-enzyme environments, resulting in insufficient detection sensitivity and selectivity.

Method used

We designed a water-soluble, achiral rare-earth tetrahedral cage CPL probe, Eu4L4, and achieved highly selective recognition and quantitative detection of thiol amino acids by combining an external hydrophilic and an internal hydrophobic structure with hydrogen bonding and hydrophobic effects.

Benefits of technology

It achieves efficient identification and quantitative detection of thiol amino acids, significantly improving the selectivity and sensitivity of detection, and can maintain stability and high solubility in complex environments.

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Abstract

The application discloses a water-soluble achiral rare earth tetrahedral cage CPL probe for recognition of mercapto amino acids and a preparation method thereof, and relates to a CPL probe for recognition of mercapto amino acids and a preparation method thereof. The application is aimed at solving the problems that water solubility and functional cavities are difficult to balance, and specific recognition ability is limited in the detection of mercapto amino acids by using existing supramolecular cage optical probes. The water-soluble achiral rare earth tetrahedral cage CPL probe for recognition of mercapto amino acids has high water solubility, strong CPL signal and high selective rare earth tetrahedral cage probe, realizes efficient recognition and quantitative detection of mercapto amino acids such as D-penicillamine, and has the advantages that Eu4L4 is an achiral rare earth tetrahedral cage, the number of aldehyde groups is multiplied due to the tetrahedral structure, excellent circularly polarized luminescence performance is exhibited, high-precision distinction between mercapto amino acids and non-mercapto amino acids is successfully realized, and the selectivity of detection is remarkably improved.
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