Oxazoline polymer, process for its preparation and use thereof

By combining oxazoline polymers with polyvinyl alcohol and polyvinylpyrrolidone, a ternary composite network hydrogel was constructed, which solved the problems of insufficient stability and mechanical properties of existing hydrogel materials in intervertebral disc nucleus pulposus replacement, and achieved efficient and safe intervertebral disc repair and imaging effects.

CN122103560APending Publication Date: 2026-05-29SHANGHAI YISIMIAO MEDICAL INSTR CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI YISIMIAO MEDICAL INSTR CO LTD
Filing Date
2026-04-28
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

When existing hydrogel materials are used for intervertebral disc nucleus pulposus replacement, they lack stability, mechanical properties and biocompatibility, and pose risks of potential toxicity and incomplete curing, and cannot effectively simulate the hydrodynamic properties of the nucleus pulposus.

Method used

A hydrogel was formed by combining oxazoline polymers with polyvinyl alcohol and polyvinylpyrrolidone in a specific ratio and preparation method. A ternary composite network was constructed using hydrogen bonding interactions to improve the mechanical properties and stability of the material. Contrast agents were added to achieve precise delivery and monitoring.

Benefits of technology

The prepared hydrogel has good mechanical properties, stability and biocompatibility. It can be injected through a fine needle and is suitable for intervertebral disc repair. It provides support and can be located and visualized in vivo, reducing the risk of toxicity and improving the safety of treatment.

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Abstract

The application relates to the technical field of biomedical materials, and discloses an oxazoline polymer as well as a preparation method and application thereof. The oxazoline polymer provided by the application has a main chain containing more single bonds, is higher in flexibility, and is good in hydrophilicity and strong in polarity. Compared with conventional water-soluble high-molecular polymers, the oxazoline polymer provided by the application has hydrogen bond donor and hydrogen bond acceptor characteristics in the molecular structure, can form stable intermolecular interaction with various high-molecular polymers containing hydroxyl groups or carbonyl groups in a water system, can effectively improve the mechanical properties and stability of a polymer hydrogel when the oxazoline polymer is used in the polymer hydrogel, and is good in biocompatibility.
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