Intestinal microbial functional marker combination for diagnosing allergy risk of infant and young children and construction method and application of model thereof

By constructing a phased combination and evaluation model of gut microbiota functional markers, the problem of accuracy in allergy risk assessment for infants and young children was solved, enabling personalized risk assessment for different developmental stages and improving the accuracy and clinical applicability of the model.

CN122104887APending Publication Date: 2026-05-29DIPROBIO (SHANGHAI) CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DIPROBIO (SHANGHAI) CO LTD
Filing Date
2026-02-03
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

Existing technologies cannot accurately assess the risk of allergies in infants and young children, especially failing to fully consider the differences in gut microbiota and functional information at different developmental stages, resulting in insufficient model accuracy and clinical applicability.

Method used

A combination of gut microbiota functional biomarkers and their evaluation model were constructed for infants and young children aged 0-6 years. The abundance of functional genes and KEGG pathway activity were obtained through metagenomic sequencing. Combined with machine learning methods, an allergy risk assessment model was constructed in stages, and multi-dimensional analysis was carried out in conjunction with clinical characteristics.

Benefits of technology

It enables precise and personalized assessment of allergy risk in infants and young children, improves the accuracy and generalization ability of the model, and can reveal the core mechanism of the gut microbiota and its relationship with host immunity at the functional level, thus meeting the needs of clinical decision support.

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Abstract

The application discloses a combination of intestinal microbial functional markers for diagnosing allergic risk of infants and young children and a construction method and application of a model thereof. The combination of intestinal microbial functional markers for diagnosing allergic risk of infants and young children and the kit thereof can accurately and efficiently diagnose the microecological allergic risk of infants and young children of different ages. By integrating multi-dimensional characteristics such as functional gene abundance and KEGG metabolic pathway function activity level, the model can reveal the core mechanism of affecting the host immunity from the perspective of the function of the flora, thereby improving the prediction efficiency and enhancing the biological interpretability of the model. The AUC of the method reaches 0.84 on the test set, indicating that the method has good ability to distinguish allergic and non-allergic individuals. The models of different age groups all have high consistency, proving that the method is stable and reliable and can meet the accuracy requirements of clinical auxiliary decision-making.
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