Method for detecting lung cancer marker 2-pentanone by metal-organic framework UiO-66 modified terahertz metasurface

By constructing a multilayer structure and multiple resonant modes on a terahertz metasurface, the problems of sensor stability and cross-sensitivity were solved, achieving high sensitivity and selectivity for the detection of 2-pentanone, and improving the accuracy and stability of the detection.

CN122109010APending Publication Date: 2026-05-29GUILIN UNIV OF ELECTRONIC TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUILIN UNIV OF ELECTRONIC TECH
Filing Date
2026-03-25
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

Existing terahertz gas sensors suffer from problems such as insufficient adhesion of the functional layer leading to poor device stability and reliance on single-parameter readout resulting in cross-sensitivity and poor recognition, making it difficult to efficiently and accurately detect 2-pentanone.

Method used

A multi-resonant metasurface consisting of an S-shaped open resonant ring and a metal antenna is constructed, and an APTES coupling layer, a PEI enrichment layer and a UiO-66 adsorption layer are introduced on its surface to build a multi-layer structure to achieve stable attachment and multi-parameter readout. The frequency shift of multiple resonance valleys and their ratio relationship are used for detection.

Benefits of technology

It achieves high sensitivity and anti-interference recognition of 2-pentanone, reduces cross-sensitivity issues in complex matrices, improves detection accuracy and stability, and provides high-dimensional data support for disease diagnosis.

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Abstract

The application discloses a kind of metal organic framework UiO-66 modified terahertz super surface detection lung cancer marker 2-pentanone method.The method is based on a kind of terahertz multi-resonance super surface sensor, and its unit structure is composed of two S-shaped open resonant ring and an antenna, produces three independent resonant valleys.To improve detection selectivity and structural stability, the application is functionalized to super surface using three-layer modification strategy: APTES is introduced in sequence to form stable interface layer, spin-coated amino-rich PEI layer is provided with additional adsorption sites to interact with ketone molecules, and finally spin-coated metal organic framework UiO-66 is used as sensing layer to realize effective pre-enrichment of 2-pentanone.During detection, three resonant valleys show linear red shift with the increase of 2-pentanone concentration, and the lowest test concentration is 20 ppm.The application uses multi-resonance characteristics combined with multi-dimensional response mode to realize rapid, high-sensitivity and high-selectivity non-contact detection of lung cancer marker 2-pentanone.
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