A glycyrrhizic acid nanomedicine, its preparation method and application

By degrading glycyrrhizic acid nanomedicines within tumor cells, triggering pyroptosis and regulating the expression of proliferation factors, the problems of low response rate and spread in tumor immunotherapy are solved, achieving efficient tumor suppression and immune activation.

CN122124073APending Publication Date: 2026-06-02HARBIN ENG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HARBIN ENG UNIV
Filing Date
2026-03-18
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

Current tumor immunotherapy has low immune response rates and difficulty in effectively controlling tumor cell proliferation and spread. Existing targeted strategies are costly, inefficient, and carry the risk of tumor spread.

Method used

Glycyrrhizate nanomedicines were prepared via a microemulsion method. They were rapidly degraded in the acidic lysosomes of tumor cells, releasing ions and triggering pyroptosis, activating the immune response and regulating the expression of proliferation-related factors, thereby inhibiting the abnormal proliferation of tumor cells.

Benefits of technology

It effectively activates the systemic anti-tumor immune response, inhibits the spread of tumor cells, and enhances the efficacy of tumor immunotherapy. It is also simple to prepare and has high safety.

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Abstract

This invention discloses a glycyrrhizic acid nanomedicine, its preparation method, and its applications, belonging to the field of biomedical nanomaterials technology. The glycyrrhizic acid nanomedicine is prepared by reacting ammonium glycyrrhizate and sodium oleate at a temperature of 15-40 °C. o Glycyrrhizate nanomedicine was prepared via a microemulsion method at temperature C. After entering tumor cells, the glycyrrhizate nanomedicine was rapidly degraded within the acidic lysosomes of the tumor cells, releasing a large amount of sodium. + The presence of glycyrrhizic acid ions and glycyrrhizic acid ions causes a surge in intracellular ion concentration and osmotic pressure, as well as the accumulation of glycyrrhizic acid within tumor cells. This induces pyroptosis in tumor cells and regulates the expression of proliferation-related proteins. Pyroptosis releases a large number of damage-associated molecular patterns (DAMPs) to trigger immune activation, while the regulation of proliferation-related protein expression inhibits tumor cell proliferation. Under the combined effect of these two factors, glycyrrhizic acid nanomedicines can not only activate the systemic anti-tumor immune response but also reduce tumor cell spread, thereby effectively inhibiting tumor growth and metastasis and enhancing the efficacy of tumor immunotherapy.
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