Nanoparticles prepared from Hedyotis diffusa and their applications

By extracting nanoparticles from Hedyotis diffusa to activate endogenous γδT cells in the gut, the limitations of existing technologies for colorectal cancer treatment have been overcome, achieving safe and efficient immunotherapy.

CN122124146APending Publication Date: 2026-06-02NANJING UNIV OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING UNIV OF TRADITIONAL CHINESE MEDICINE
Filing Date
2026-04-20
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

Current technologies lack effective and low-toxicity local interventions to activate endogenous γδT cells in the gut, limiting immunotherapy strategies for treating colon cancer. Furthermore, existing γδT cell immunotherapy techniques are complex and costly.

Method used

Nanoparticles were extracted from Hedyotis diffusa using a combination of differential centrifugation and ultra-high-speed centrifugation. These nanoparticles, as the sole active ingredient, were used in oral or injectable formulations to activate endogenous γδT cells in the gut and significantly upregulate the expression of IFN-γ.

Benefits of technology

Hedyotis diffusa nanoparticles significantly activate intestinal γδT cells, increase IFN-γ expression, effectively inhibit colon cancer growth, have high biosafety, and are easy to operate, making them suitable for laboratory and large-scale production.

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Abstract

This invention relates to the field of biotechnology, specifically to nanoparticles prepared from *Hedyotis diffusa* and their applications. The invention uses *Hedyotis diffusa* as raw material and prepares nanoparticles by differential centrifugation at low, medium, and ultra-high speeds. The nanoparticles have a particle size of 100-200 nm, exhibit a spherical membrane structure, and are uniformly distributed. These nanoparticles contain various proteins, lipids, and RNA. Oral delivery of *Hedyotis diffusa*-derived nanoparticles effectively activates immune cells in the intestine, including T cells, especially γδT cells. Experiments have shown that these *Hedyotis diffusa*-derived nanoparticles can significantly reverse the immunosuppressive tumor microenvironment of colon cancer in the intestine and delay tumor growth.
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