An extracorporeal cerebrospinal fluid filtration dialysis device

Abstract

This invention discloses a cerebrospinal fluid external filtration and dialysis device for the purification and treatment of cerebrospinal fluid in diseases such as central nervous system infections and subarachnoid hemorrhage. The device includes a dual-lumen drainage tube, comprising an outflow pipe and an inflow pipe. The outflow pipe is connected to the inlet of the filtration and dialyzer via a suction-side connecting pipe. The suction-side connecting pipe passes through a peristaltic pump and is equipped with a sampling pipe, on which a detachable timed sampler is mounted. The first outlet of the filtration and dialyzer is connected to a storage bag via a suction connecting pipe, and the second outlet is connected to the inflow pipe via a return connecting pipe. Pressure sensors are installed on both the suction-side and return connecting pipes, and a flow meter is installed on the return connecting pipe. These components form a feedback control loop with a control processor to adjust the pump speed and valve opening and closing, achieving safe and controllable flow and pressure. This device can filter / dialyze pathogens and inflammation-related substances in cerebrospinal fluid and return them, while simultaneously performing timed sampling for dynamic monitoring.

Description

Technical Field

[0001] This invention relates to the field of cerebrospinal fluid purification and treatment technology, specifically to a cerebrospinal fluid external filtration and dialysis device. Background Technology

[0002] Central nervous system infections (CNSIs), including bacterial / viral / fungal meningitis, ventriculitis, and related infection syndromes, are among the most common and high-risk causes of critical illness in neurocritical care and neurosurgery. Clinically, these diseases have a rapid onset and progression, often presenting with altered consciousness, seizures, obstruction of cerebrospinal fluid circulation, and increased intracranial pressure. If the pathogen persists or the inflammatory response is difficult to control, it can further induce serious complications such as cerebral edema, brain herniation, hydrocephalus, vasculitis, and ischemic injury, leading to high mortality and disability rates. Cryptococcal meningitis, drug-resistant meningitis, and postoperative / catheter-related ventriculitis are particularly problematic, characterized by prolonged disease courses, high recurrence rates, long treatment cycles, and significant clinical burden.

[0003] Currently, the treatment of central nervous system infections mainly relies on anti-infective drugs (including antibacterial, antiviral, and antifungal drugs) and symptomatic supportive care. However, due to the blood-brain barrier and blood-cerebrospinal fluid barrier, many drugs struggle to achieve stable and sufficient effective concentrations in the cerebrospinal fluid, and drug distribution within the lesion is significantly uneven. Furthermore, increasing the dosage or intensifying the dosing regimen to improve cerebrospinal fluid drug exposure can easily lead to systemic adverse reactions such as liver and kidney toxicity, bone marrow suppression, and electrolyte disturbances, resulting in a common clinical contradiction of "limited efficacy - limited dosage." For patients with persistently elevated inflammatory mediators and long-term presence of pathogens and their antigenic load, even after completing standard anti-infective treatment, persistent intracranial pressure, recurrent fever, headache, neurological impairment, or hydrocephalus may still occur due to the inflammatory cascade and impaired cerebrospinal fluid circulation, presenting a significant treatment bottleneck.

[0004] To reduce intracranial pressure and improve the cerebrospinal fluid environment, lumbar cistern / external ventricular drainage is commonly used in clinical practice for cerebrospinal fluid drainage and monitoring. However, traditional simple drainage mainly focuses on "drainage," which has the following shortcomings: First, it is difficult to precisely control the amount and rate of cerebrospinal fluid drainage. If too much or too fast is drained, it can easily lead to a rapid drop in intracranial pressure and intracranial pressure imbalance, which may induce brain herniation and nerve damage in severe cases. Second, single-lumen catheters are prone to problems such as tube blockage and reflux contamination during long-term drainage, affecting continuous treatment. Third, simple drainage only reduces the total amount and cannot specifically reduce the pathogenic components such as pathogens, antigens, and inflammatory factors that are constantly present in the cerebrospinal fluid, making it difficult to achieve closed-loop regulation of "purification-reinfusion."

[0005] Furthermore, in common neurosurgical critical conditions such as subarachnoid hemorrhage (SAH), bloody cerebrospinal fluid (CSF) and its decomposition products, along with inflammatory mediators, within the subarachnoid space can chronically irritate the meninges and blood vessel walls, easily leading to complications such as cerebral vasospasm, delayed cerebral ischemia, recurrent headaches, seizures, and communicating hydrocephalus. Failure to effectively and controllably remove bloody CSF and reduce the inflammatory burden in the early postoperative period will significantly impact patient prognosis. While some existing CSF purification protocols borrow from hemodialysis principles for extracorporeal treatment, they still have shortcomings in safety control, the scope of filtration targets (especially small / medium molecule substances such as inflammatory mediators), and closed-loop control of drainage and reinfusion flow and pressure, making it difficult to simultaneously achieve both "effective purification" and "intracranial pressure stability."

[0006] Therefore, there is an urgent need for an external filtration dialysis device for cerebrospinal fluid. Summary of the Invention

[0007] To address the shortcomings of existing technologies, this invention proposes an external filtration and dialysis device for cerebrospinal fluid. This device can achieve external filtration / dialysis purification of pathogens and inflammatory mediators in cerebrospinal fluid while ensuring safe and controllable intracranial pressure and flow rate. The purified cerebrospinal fluid is then reinfused into the body to form a closed-loop treatment. At the same time, it meets the clinical need for regular sampling and testing to dynamically evaluate treatment effects and guide medication.

[0008] To solve the above-mentioned technical problems, the technical solution adopted by the present invention is as follows: An external filtration dialysis device for cerebrospinal fluid, comprising: The drainage tube is a dual-lumen tube, consisting of an outflow drainage tube and an inflow drainage tube; The filter dialyzer has its inlet and outlet connected by a suction side connecting pipe. The end of the suction side connecting pipe near the filter dialyzer is connected to a liquid collection pipe, which is detachably equipped with a timed liquid collector. A peristaltic pump, wherein the suction-side connecting tube passes through the interior of the peristaltic pump, so that the peristaltic pump is used to power the cerebrospinal fluid inside the suction-side connecting tube; and The liquid storage bag has its inlet connected to the first outlet of the filter dialyzer via a suction connection pipe; the inlet of the drainage inlet pipe is connected to the second outlet of the filter dialyzer via a return-side connection pipe.

[0009] The aforementioned external filtration and dialysis device for cerebrospinal fluid (CSF) removes cryptococcus, viral pathogens, and hemorrhage-degraded proteins from the CSF of patients with central nervous system infections or cerebral hemorrhage through a filtration dialyzer. The filtered, clean CSF is then reinfused into the normal CSF circulation. This physical dialysis and filtration method achieves the goal of drug chemotherapy for CSF infections or hemorrhage, and significantly reduces short-term and long-term complications such as hydrocephalus and intracranial hypertension caused by CSF infections and cerebral hemorrhage. Furthermore, a timed sampler is used to periodically collect CSF samples during the dialysis and filtration process for real-time rapid testing, enabling dynamic, real-time, and precise monitoring of the CSF dialysis and filtration efficacy.

[0010] Furthermore, a suction-side pressure sensor is provided on the suction-side connecting pipe, a return-side pressure sensor is provided on the return-side connecting pipe, and a control processor is provided on the filter dialyzer. Both the suction-side pressure sensor and the return-side pressure sensor are electrically connected to the control processor. The control processor is used to adjust the pump speed of the peristaltic pump and / or the opening and closing of the valve according to the pressure signal.

[0011] Furthermore, a flow meter is installed on the reinfusion-side connecting pipe, and the flow meter is electrically connected to the control processor; a replenishment tank is also installed on the reinfusion-side connecting pipe, which is used to replenish artificial cerebrospinal fluid to the reinfusion-side connecting pipe.

[0012] Furthermore, a diversion valve is provided on the suction connection pipe, and a replenishment valve is provided on the outlet of the replenishment tank.

[0013] Furthermore, the filter dialyzer includes an outer shell and an inner shell. The inner shell is coaxially fitted inside the outer shell. A filter membrane is detachably installed in an opening at the bottom of the inner shell. The outlet end of the suction-side connecting pipe extends through the top of the outer shell to the inner top of the inner shell. The inlet of the return-side connecting pipe is connected to the inner bottom of the outer shell. The suction connecting pipe passes through the side wall of the outer shell and is connected to the bottom of the outer wall of the inner shell.

[0014] Furthermore, the timed liquid dispenser includes a housing, inside which a vertical partition is fixedly installed. The partition divides the interior of the housing into a liquid dispensing chamber and a driving chamber. The liquid dispensing chamber is equipped with a liquid dispensing component, and the driving chamber is equipped with a driving component. By driving the liquid dispensing component to rotate, the cerebrospinal fluid flowing from the liquid dispensing tube flows into different liquid dispensing bottles at regular intervals. A horizontal partition is detachably installed at the top of the interior of the liquid dispensing chamber. A liquid dispensing hole is opened on one side of the top of the horizontal partition. The end of the liquid dispensing tube extends through the housing and is inserted into the liquid dispensing hole.

[0015] Furthermore, the liquid dispensing assembly includes a rotating plate and multiple dispensing bottles. The rotating plate is rotatably mounted on the inner bottom wall of the dispensing chamber, and a toothed ring is fixedly provided on the outer side of the rotating plate. Multiple dispensing bottles are detachably mounted on the top of the rotating plate along the circumferential direction. The drive assembly includes a drive motor and a rotating shaft. The base of the drive motor is fixedly mounted on the inner bottom wall of the drive cavity. The bottom of the rotating shaft is fixedly connected to the output shaft of the drive motor. The top of the rotating shaft is rotatably connected to the inner top wall of the drive cavity. A missing gear is fixedly sleeved on the bottom of the outer wall of the rotating shaft. The missing gear can mesh with the gear ring. The missing gear is driven to rotate by the timing of the drive motor, so that the missing gear drives the gear ring to rotate by the required angle.

[0016] Furthermore, the liquid dispensing assembly also includes multiple liquid dispensing caps, a fixing ring, and a liquid dispensing rotating rod. The multiple liquid dispensing caps are rotatably placed on the top opening of the corresponding liquid dispensing bottle. A fixing ring is fixedly provided on the top of the outer wall of the liquid dispensing bottle. The bottom of the liquid dispensing rotating rod is rotatably inserted into the fixing ring. The top of the liquid dispensing rotating rod is fixedly connected to one side of the outer side of the liquid dispensing cap. A torsion spring is sleeved on the outer side of the liquid dispensing rotating rod. One end of the torsion spring is fixedly connected to the outer wall of the liquid dispensing rotating rod, and the other end is fixedly connected to the outer wall of the fixing ring. A liquid dispensing lever is fixedly provided on the top of the liquid dispensing rotating rod. The drive assembly also includes a drive ring, which is fixedly sleeved on the top of the outer wall of the rotating shaft. A drive rod is fixedly connected to one side of the outer surface of the drive ring. The drive rod can abut against the liquid dispensing lever, thereby driving the liquid dispensing lever to rotate the liquid dispensing cover horizontally.

[0017] Furthermore, the liquid dispensing assembly also includes a liquid dispensing screw and a liquid dispensing block. One end of the liquid dispensing block is fixedly sleeved on the outside of the liquid dispensing bottle, and the other end of the liquid dispensing block is rotatably sleeved on the outside of the liquid dispensing screw. The bottom of the liquid dispensing screw is rotatably connected to the top of the rotating plate. The drive assembly also includes a drive master gear and a drive slave gear. The drive gear is sleeved on the outer wall of the rotating shaft, and the drive slave gear is threaded on the outer wall of the liquid-collecting screw thread rod. The top of the drive slave gear is rotatably connected to the bottom of the other end of the liquid-collecting block, and the drive master gear and the drive slave gear are meshed together.

[0018] Furthermore, the liquid dispensing assembly also includes multiple elastic blocks. The top of the rotating plate has multiple support grooves along the circumferential direction. The upper side of the elastic block is a rigid silicone block and the lower side is an elastic silicone cover. The elastic silicone cover in the elastic block is fixedly installed on the top opening of the support groove. The top of the rigid silicone block in the elastic block has a fixing groove. The bottom of the liquid dispensing bottle is set in the fixing groove. Each of the multiple support grooves is provided with a support spring. One end of the support spring is fixedly connected to the inner bottom wall of the support groove, and the other end is fixedly connected to the inner top wall of the rigid silicone block in the elastic block.

[0019] The beneficial effects of this invention are: 1. This external filtration and dialysis device for cerebrospinal fluid uses a dialysis dialyzer to remove cryptococci, viral pathogens, and hemorrhage-degraded proteins from the cerebrospinal fluid of patients with central nervous system infections or cerebral hemorrhage. The filtered, clean cerebrospinal fluid is then reinfused into the normal cerebrospinal fluid circulation. This physical dialysis and filtration method achieves the goal of drug chemotherapy for central nervous system infections or hemorrhage, and significantly reduces short-term and long-term complications such as hydrocephalus and intracranial hypertension caused by central nervous system infections and cerebral hemorrhage. During the dialysis and filtration process, a timed sampler is used to periodically collect cerebrospinal fluid samples for real-time rapid testing, enabling dynamic, real-time, and precise monitoring of the cerebrospinal fluid dialysis and filtration efficacy.

[0020] 2. This cerebrospinal fluid external filtration dialysis device monitors the pressure and flow rate changes of cerebrospinal fluid through suction-side pressure sensors, return-side pressure sensors, and flow meters. The data is then processed and analyzed by a control processor to adjust the pump speed of the peristaltic pump and open / close the replenishment valve.

[0021] 3. This cerebrospinal fluid external filtration dialysis device, through the coordinated operation of the liquid collection component and the drive component, enables the liquid collection bottle to move, rise, and open simultaneously, thereby allowing the liquid collection bottle to collect the required amount of cerebrospinal fluid for subsequent testing. Attached Figure Description

[0022] To more clearly illustrate the specific embodiments of the present invention, the accompanying drawings used in the specific embodiments will be briefly described below. In all the drawings, the elements or parts are not necessarily drawn to scale.

[0023] Figure 1 This is a schematic diagram of the structure of the present invention; Figure 2 This is a schematic diagram of the structure of the filter dialyzer in this invention; Figure 3 This is a schematic diagram of the timed liquid dispenser of the present invention; Figure 4 This is a schematic diagram of the liquid extraction component in this invention; Figure 5 This is a schematic diagram of the transmission of the magnetic ring and the missing gear in this invention; Figure 6 This is a schematic diagram of the transmission of the liquid-retrieving lever and the drive lever in this invention; Figure 7 This is a schematic diagram showing the connection between the liquid dispensing bottle and the liquid dispensing cap in this invention; Figure 8 This is a schematic diagram of the transmission system for driving the main gear, driving the driven gear, and the liquid-collecting screw in this invention. Figure 9 This is a schematic diagram of another structure of the drainage tube in this invention.

[0024] Figure label: 10-Drainage tube, 11-Drainage outlet pipe, 12-Drainage inlet pipe; 21-Suction side connection pipe, 22-Return side connection pipe, 23-Suction connection pipe, 24-Suction side pressure sensor, 25-Return side pressure sensor, 26-Flow meter, 27-Replenishment tank, 271-Replenishment valve, 28-Control processor, 29-Liquid dispensing pipe, 291-Three-way liquid dispensing valve; 30 - Peristaltic pump; 40-Filter dialyzer, 41-Outer shell, 42-Inner shell, 43-Filter membrane, 44-Bottom ring cover, 45-Screw; 50 - Liquid storage bag; 51 - Drainage valve; 60-Timed liquid dispenser; 61-Box body; 611-Liquid dispensing chamber; 612-Drive chamber; 62-Vertical partition; 63-Horizontal partition; 631-Liquid dispensing hole; 64-Box cover; 65-Liquid dispensing assembly; 6511-Rotating plate; 6512-Liquid dispensing bottle; 6513-Gear ring; 6521-Liquid dispensing cap; 6522-Fixing ring; 6523-Liquid dispensing rotating rod; 6524-Torsion spring; 6525-Liquid dispensing lever; 6526-Magnetic sheet 6527-Iron ring, 6531-Liquid extraction screw, 6532-Liquid extraction block; 66-Drive assembly, 6611-Drive motor, 6612-Rotating shaft, 6613-Missing gear, 6621-Drive ring, 6622-Drive rod, 6631-Drive main gear, 6632-Drive driven gear; 67-Elastic block, 671-Hard silicone block, 672-Elastic silicone cover, 673-Support spring, 674-Support groove. Detailed Implementation

[0025] The embodiments of the technical solution of the present invention will now be described in detail with reference to the accompanying drawings. These embodiments are merely illustrative of the technical solution of the present invention and are therefore intended to limit the scope of protection of the present invention.

[0026] In the description of this invention, it should be understood that the terms "center", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation and positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the indicated position or element must have a specific orientation, or be constructed and operated in a specific way. Therefore, they should not be construed as limitations on this invention.

[0027] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, features defined as "first" or "second" may explicitly or implicitly include one or more features. In the description of this invention, "a plurality of" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0028] Please see Figure 1 The present invention provides a cerebrospinal fluid external filtration and dialysis device, comprising a drainage tube 10, a filtration dialyzer 40, a peristaltic pump 30, and a storage bag 50. The drainage tube 10 is a dual-lumen pipe, consisting of a drainage outlet pipe 11 and a drainage inlet pipe 12. The inlet of the filtration dialyzer 40 and the outlet of the drainage outlet pipe 11 are connected by a suction-side connecting pipe 21. The end of the suction-side connecting pipe 21 near the filtration dialyzer 40 is connected to a liquid collection pipe 29, which is detachable from the liquid collection pipe 29. The device is equipped with a timed fluid extractor 60; the suction-side connecting tube 21 passes through the interior of the peristaltic pump 30, enabling the peristaltic pump 30 to power the cerebrospinal fluid inside the suction-side connecting tube 21; the inlet of the fluid storage bag 50 is connected to the first outlet of the filter dialyzer 40 via a suction connecting tube 23, and the inside of the fluid storage bag 50 has a negative pressure suction force; the inlet of the drainage inlet pipe 12 is connected to the second outlet of the filter dialyzer 40 via a return-side connecting tube 22. The peristaltic pump 30 has ten rotating rollers, making it easier to adjust the flow rate of the cerebrospinal fluid in the suction-side connecting tube 21.

[0029] In operation, multiple rotating rollers within the peristaltic pump 30 sequentially squeeze the suction-side connecting tube 21, creating a negative pressure suction within it. This causes the drainage outlet tube 11 to draw cerebrospinal fluid (CSF) from the lumbar cisterns into the filter dialyzer 40. The filter dialyzer 40 removes cryptococci, viral pathogens, and degradation proteins from cerebral hemorrhage within the CSF. The filtered CSF then flows through the return-side connecting tube 22 into the drainage inlet tube 12, and subsequently back into the ventricles of the brain. The waste fluid produced by the filter dialyzer 40 flows into the storage bag 50. This entire CSF filtration and purification process not only removes cryptococci, viral pathogens, and degradation proteins from the CSF, but also allows the peristaltic pump 30 to control the flow rate of the CSF, preventing rapid changes in intracranial pressure.

[0030] Preferably, a suction-side pressure sensor 24 is installed on the suction-side connecting pipe 21, and a return-side pressure sensor 25 is installed on the return-side connecting pipe 22. A flow meter 26 and a replenishment tank 27 are installed at the end of the return-side connecting pipe 22, between the return-side pressure sensor 25 and the filter dialyzer 40. The replenishment tank 27 is located on the side close to the filter dialyzer 40, and contains artificial cerebrospinal fluid. A drainage valve 51 is installed on the suction connecting pipe 23, and a replenishment valve 271 is installed at the outlet of the replenishment tank 27. A control processor 28 is installed on the filter dialyzer 40. The suction-side pressure sensor 24, the return-side pressure sensor 25, the replenishment valve 271, and the flow meter 26 are all electrically connected to the control processor 28. The control processor 28 is used to receive various signals and, after processing, control the opening and closing of each valve.

[0031] During the cerebrospinal fluid (CSF) filtration and purification process, pressure and flow rate changes of the CSF are monitored by the aspiration-side pressure sensor 24, the reinfusion-side pressure sensor 25, and the flow meter 26, thus forming a dual feedback loop for safety and flow control. When the aspiration-side pressure sensor 24 detects that the pressure at the CSF aspiration point exceeds the set threshold on the control processor 28, the control processor 28 reduces the pump speed upon receiving the signal. When the reinfusion-side pressure sensor 25 detects an abnormally high pressure at the CSF return point, the control processor 28 adjusts the pump speed upon receiving the signal. The flow meter 26, installed on the reinfusion-side connecting pipe 22, is used to ensure the controllability of the treatment dose, guaranteeing the set filtration dose, such as allowing only a net removal of 12-15 mL CSF per hour. It also monitors for blockages, leaks, and filter membrane clogging. If the pump is running but the flow rate decreases, it indicates an abnormality in the purification treatment process, providing a basis for adjusting and opening the infusion valve 271.

[0032] In use, the pressure of cerebrospinal fluid (CSF) is monitored by the suction side pressure sensor 24 and the return side pressure sensor 25 when it is drained from the lumbar cistern and when it is drained into the ventricle, respectively. This allows the change in CSF pressure before and after filtration to be observed. After the pressure signal is transmitted to the control processor 28, it is determined whether the intracranial pressure change exceeds the set threshold of the control processor 28, thereby adjusting the flow rate of CSF. At the same time, the monitoring value of the flow meter 26 is added to determine the change in CSF flow rate. If the CSF flow rate decreases, the control processor 28 controls the opening of the replenishment valve 271, allowing the artificial CSF in the replenishment tank 27 to flow out into the return side connecting tube 22, thereby replenishing the reduced amount of CSF.

[0033] like Figure 1 and Figure 9As shown, it is worth noting that the drainage tube 10 can be a Y-shaped double-lumen tube, wherein the combined drainage outlet tube 11 and drainage inlet tube 12 are respectively connected to the suction side connecting tube 21 and the return side connecting tube 22, and the separate drainage outlet tube 11 and drainage inlet tube 12 have a longer length than the drainage outlet tube 11. The drainage inlet tube 12 is punctured into the human body and extends to the ventricle, while the drainage outlet tube 11 is punctured and fixed at the lumbar spine position. Alternatively, the drainage tube 10 can be made into two separate tubes, namely the outflow drainage tube 11 and the inflow drainage tube 12. The outflow drainage tube 11 is punctured, inserted and fixed in the lumbar spine, and the inflow drainage tube 12 is directly punctured and fixed in the brain.

[0034] Please refer to the following: Figure 2 In this embodiment, the filtration dialyzer 40 includes an outer shell 41 and an inner shell 42. The inner shell 42 is coaxially fitted inside the outer shell 41. A filter membrane 43 is detachably installed in an opening at the bottom of the inner shell 42. The pore diameter of the filter membrane 43 is smaller than that of cryptococcus, viral pathogens, and cerebral hemorrhage degradation proteins. The outlet end of the suction-side connecting pipe 21 extends through the top of the outer shell 41 to the inner top of the inner shell 42. The inlet of the return-side connecting pipe 22 is connected to the inner bottom of the outer shell 41. The suction connecting pipe 23 passes through the side wall of the outer shell 41 and connects to the bottom of the outer wall of the inner shell 42. A bottom ring cover 44 is provided at the bottom of the inner shell 42. Multiple screws 45 are fixed to the top of the bottom ring cover 44. Multiple screw holes are opened at the bottom of the inner shell 42, and the screws 45 are inserted into the screw holes for threaded connection. The diameter of the filter membrane 43 is larger than the diameter of the opening at the bottom of the inner shell 42. Preferably, the filter membrane 43 is a semi-permeable membrane or an ultrafiltration membrane, used for filtering / dialysis separation of pathogens and inflammation-related substances in cerebrospinal fluid.

[0035] During use, the peristaltic pump 30 drives the cerebrospinal fluid in the suction-side connecting tube 21 into the inner shell 42. The cerebrospinal fluid falls onto the filter membrane 43, which filters out harmful substances such as cryptococcus, viral pathogens, and cerebral hemorrhage degradation proteins, purifying the fluid. The purified cerebrospinal fluid then flows through the filter membrane 43 into the outer shell 41, and then converges and flows back into the return-side connecting tube 22, returning to the ventricles of the brain. When harmful liquid containing cryptococcus, viral pathogens, and cerebral hemorrhage degradation proteins remains in the inner shell 42, the drainage valve 51 is opened, allowing the harmful liquid to flow into the storage bag 50.

[0036] Please refer to the following: Figure 3 and Figure 4In this embodiment, the liquid collector includes a housing 61. A vertical partition 62 is fixedly installed inside the housing 61, dividing the interior of the housing 61 into a liquid collection chamber 611 and a driving chamber 612. A liquid collection component 65 is installed inside the liquid collection chamber 611, and a driving component 66 is installed inside the driving chamber 612. The driving component 66 drives the liquid collection component 65 to rotate, so that the cerebrospinal fluid flowing out of the liquid collection tube 29 flows into different liquid collection bottles 6512 at regular intervals. A horizontal partition 63 is detachably installed on the top of the interior of the liquid collection chamber 611. A liquid collection hole 631 is opened on one side of the top of the horizontal partition 63. The end of the liquid collection tube 29 extends through into the interior of the housing 61 and is inserted into the liquid collection hole 631. A three-way liquid collection valve 291 is installed between the outlet of the suction side connecting pipe 21, the liquid collection tube 29 and the filter dialyzer 40. The three-way liquid collection valve 291 is electrically connected to the control processor 28. The top of the housing 61 is equipped with a removable cover 64, through which the liquid extraction tube 29 passes and is inserted into the liquid extraction hole 631. The cover 64 is connected to the top of the housing 61 via a plug-in slot.

[0037] Please refer to the following: Figure 5 Specifically, the liquid dispensing assembly 65 includes a rotating plate 6511 and multiple dispensing bottles 6512, each marked with a number for easy identification of the dispensing order. The rotating plate 6511 is rotatably mounted on the inner bottom wall of the dispensing chamber 611, and a toothed ring 6513 is fixedly mounted on the outer side of the rotating plate 6511. The multiple dispensing bottles 6512 are detachably mounted on the top of the rotating plate 6511 along the circumferential direction. The driving assembly 66 includes a driving motor 6611 and a rotating shaft 6612. The bottom of the driving motor 6611... The base is fixedly mounted on the inner bottom wall of the drive cavity 612. The bottom of the rotating shaft 6612 is fixedly connected to the output shaft of the drive motor 6611, and the top of the rotating shaft 6612 is rotatably connected to the inner top wall of the drive cavity 612. A missing gear 6613 is fixedly sleeved on the bottom of the outer wall of the rotating shaft 6612. The missing gear 6613 can mesh with the gear ring 6513. The drive motor 6611 drives the missing gear 6613 to rotate at the required angle. The drive motor 6611 is electrically connected to the control processor 28. The interval time is input into the control processor 28, so that the liquid extractor automatically extracts cerebrospinal fluid.

[0038] During use, to facilitate monitoring the effectiveness of cerebrospinal fluid purification treatment in patients, a certain amount of cerebrospinal fluid needs to be collected for testing at regular intervals. The drive motor 6611 starts, driving the rotating shaft 6612 to rotate. The rotating shaft 6612 drives the gear 6613 to rotate, which in turn drives the gear ring 6513 and the rotating plate 6511 to rotate synchronously. This causes the collection bottle 6512 on the rotating plate 6511 to rotate below the collection port 631. Simultaneously, the control processor 28 activates the three-way collection valve 291, allowing the cerebrospinal fluid in the aspiration side connecting tube 21 to flow into the collection tube 29, while the flow towards the filter dialyzer 40 is closed, ultimately allowing the required amount of cerebrospinal fluid to be collected. Cerebrospinal fluid flows into the collection bottle 6512, and then resumes flowing into the filter dialyzer 40. Since only part of the outer side of the missing gear 6613 meshes with the gear ring 6513, the rotating shaft 6612 only drives the rotating plate 6511 to rotate a certain angle. After that, the missing gear 6613 disengages from the gear ring 6513. After a set interval, the drive motor 6611 restarts, allowing the required amount of cerebrospinal fluid to flow into the second collection bottle 6512. The above operation is then repeated.

[0039] Please refer to the following: Figure 6 and Figure 7 ,in Figure 6In the diagram, (a) shows the liquid dispensing lever 6525 and the drive rod 6622 not in contact, and (b) shows the liquid dispensing lever 6525 and the drive rod 6622 in contact. Preferably, the liquid dispensing assembly 65 further includes multiple liquid dispensing caps 6521, a fixing ring 6522, and a liquid dispensing rotating rod 6523. The multiple liquid dispensing caps 6521 are rotatably mounted on the top opening of the corresponding liquid dispensing bottle 6512. A fixing ring 6522 is fixedly provided on the top of the outer wall of the liquid dispensing bottle 6512. The bottom of the liquid dispensing rotating rod 6523 is rotatably inserted into the fixing ring 6522. The top of the liquid dispensing rotating rod 6523 is fixedly connected to one side of the outer surface of the liquid dispensing cap 6521. A torsion spring 6524 is sleeved on the outer side of the liquid dispensing rotating rod 6523. One end of the liquid dispensing rotating rod 6523 is fixedly connected to the outer wall of the liquid dispensing rotating rod 6523, and the other end is fixedly connected to the outer wall of the fixing ring 6522. A liquid dispensing lever 6525 is fixedly provided on the top of the liquid dispensing rotating rod 6523. The driving assembly 66 also includes a driving ring 6621, which is fixedly sleeved on the top of the outer wall of the rotating shaft 6612. A driving rod 6622 is fixedly connected to one side of the outer side of the driving ring 6621. The driving rod 6622 can abut against the liquid dispensing lever 6525, thereby driving the liquid dispensing lever 6525 to drive the liquid dispensing cover 6521 to rotate horizontally. The liquid dispensing cover 6521 has an iron ring 6527 at the bottom, and a magnetic sheet 6526 is provided on one side of the top of the liquid dispensing bottle 6512. The magnetic connection between the iron ring 6527 and the magnetic sheet 6526 can strengthen the connection between the liquid dispensing cover 6521 and the liquid dispensing bottle 6512, but will not affect the driving rod 6622 from pushing the liquid dispensing lever 6525 to rotate. The magnetic force between the iron ring 6527 and the magnetic sheet 6526 is less than the pushing force of the drive rod 6622.

[0040] In use, when the drive motor 6611 starts and drives the rotating shaft 6612 to rotate, the rotating shaft 6612 drives the gear 6613 to drive the rotating plate 6511 to rotate, so that the first liquid dispensing bottle 6512 rotates to below the liquid dispensing hole 631. At the same time, the rotating shaft 6612 drives the drive rod 6622 to rotate, so that the drive rod 6622 abuts against the liquid dispensing lever 6525. When the drive rod 6622 continues to push the liquid dispensing lever 6525 to rotate, the liquid dispensing lever 6525 drives the liquid dispensing rotating rod 6523 to rotate, and the liquid dispensing lever 6521 drives the liquid dispensing cover 6521 to rotate. Finally, the liquid dispensing cover 6521 rotates. 521 rotates horizontally, exposing the opening of the collection bottle 6512, allowing the cerebrospinal fluid in the collection tube 29 to flow into the collection bottle 6512. At this time, the torsion spring 6524 is compressed. When the drive rod 6622 continues to push the collection lever 6525 to rotate, the drive rod 6622 will disengage from the collection lever 6525, causing the collection lever 6525 to lose its pushing force. At this time, the collection lever 6525 is subjected to the restoring force of the torsion spring 6524, causing the collection lever 6525 to rotate back to reset, and finally causing the collection cap 6521 to reset and cover the top opening of the collection bottle 6512.

[0041] Please refer to the following: Figure 8 Preferably, the liquid dispensing assembly 65 further includes a liquid dispensing screw 6531 and a liquid dispensing block 6532. One end of the liquid dispensing block 6532 is fixedly sleeved on the outside of the liquid dispensing bottle 6512, and the other end of the liquid dispensing block 6532 is rotatably sleeved on the outside of the liquid dispensing screw 6531. The bottom of the liquid dispensing screw 6531 is rotatably connected to the top of the rotating plate 6511. The driving assembly 66 further includes a driving main gear 6631 and a driving driven gear 6632. The driving gear is sleeved on the outer wall of the rotating shaft 6612, and the driving driven gear 6632 is threaded on the outer wall of the threaded rod of the liquid dispensing screw 6531. The top of the driving driven gear 6632 is rotatably connected to the bottom of the other end of the liquid dispensing block 6532. The driving main gear 6631 and the driving driven gear 6632 are meshed. Part of the outer arc of the driving main gear 6631 is missing teeth. The thickness of the driven gear 6632 is greater than the thickness of the driven gear 6631, so that the driven gear 6632 does not disengage from the driven gear 6631 during the upward rotation process.

[0042] In use, when the drive motor 6611 starts and drives the rotating shaft 6612 to rotate, the rotating shaft 6612 drives the missing gear 6613 to drive the rotating plate 6511 to rotate, so that the first liquid dispensing bottle 6512 rotates to below the liquid dispensing hole 631. At the same time, the rotating shaft 6612 drives the drive main gear 6631 to rotate, and the drive main gear 6631 drives the drive driven gear 6632 to rotate. Since the drive driven gear 6632 is threadedly connected to the liquid dispensing screw 6531, the drive driven gear 6632 is positioned below the liquid dispensing screw 6531. The outer wall of the cerebrospinal fluid (CSF) bottle 6512 rotates upwards, driving the driven gear 6632 to move upwards, which in turn drives the liquid collection block 6532 to move upwards. This reduces the distance between the top of the liquid collection bottle 6512 and the bottom of the liquid collection hole 631, without affecting the reset of the liquid collection cap 6521. Simultaneously, the driven main gear 6631 disengages from the driven gear 6632, causing the driven gear 6632 to stop rotating and moving upwards, thus allowing the CSF to flow smoothly into the liquid collection bottle 6512. Furthermore, each time the liquid collection bottle 6512 is used to collect CSF, the drive motor 6611 rotates one revolution and stops, then waits for the next liquid collection bottle 6512 to collect CSF.

[0043] like Figure 4As shown, the liquid dispensing assembly 65 further includes multiple elastic blocks 67. The top of the rotating plate 6511 is provided with multiple support grooves 674 along the circumferential direction. The upper side of the elastic block 67 is a hard silicone block 671 and the lower side is an elastic silicone cover 672. The elastic silicone cover 672 in the elastic block 67 is fixedly covered on the top opening of the support groove 674. The top of the hard silicone block 671 in the elastic block 67 is provided with a fixing groove. The bottom of the liquid dispensing bottle 6512 is set in the fixing groove. Each of the multiple support grooves 674 is provided with a support spring 673. One end of the support spring 673 is fixedly connected to the inner bottom wall of the support groove 674, and the other end is fixedly connected to the inner top wall of the hard silicone block 671 in the elastic block 67.

[0044] Initially, the support spring 673 is compressed. As the liquid collection bottle 6512 moves upward, the elastic force of the support spring 673 pushes the elastic block 67 upward, providing some support to the liquid collection bottle 6512. This ensures that the height of the liquid collection bottle 6512 after collecting cerebrospinal fluid does not fall, thus distinguishing it from the liquid collection bottle 6512 in the receiving state.

[0045] The working principle of this invention is as follows: The end of the drainage tube 11 is inserted into the lumbar cistern, and the end of the drainage tube 12 is inserted from the lumbar spine to the brain. Then, the peristaltic pump 30 is activated. Multiple rotating rollers within the pump 30 sequentially squeeze the suction-side connecting tube 21, creating a negative pressure suction within it. This causes the drainage tube 11 to draw cerebrospinal fluid from the lumbar cistern into the filtration dialyzer 40. The cerebrospinal fluid then falls onto the filter membrane 43, which filters out harmful substances such as cryptococci, viral pathogens, and degradation proteins from cerebral hemorrhage, purifying the fluid. After filtration and purification, the cerebrospinal fluid flows through the filter membrane 43 into the outer shell 41, and then converges into the return-to-infusion connecting pipe 22. Afterward, the cerebrospinal fluid flows back to the brain through the drainage inlet pipe 12. Meanwhile, the harmful liquid containing cryptococcus, viral pathogens, and brain hemorrhage degradation proteins retained in the inner shell 42 flows into the storage bag 50. During the cerebrospinal fluid filtration and purification process, the pressure and flow rate changes of the cerebrospinal fluid are monitored by the suction-side pressure sensor 24, the return-to-infusion pressure sensor 25, and the flow meter 26. The data is then processed and judged by the control processor 28 to adjust the pump speed and open and close the replenishment valve 271.

[0046] When cerebrospinal fluid is collected, the drive motor 6611 starts, driving the rotating shaft 6612 to rotate. The rotation of the rotating shaft 6612 drives the missing gear 6613, the drive rod 6622, and the drive main gear 6631 to rotate simultaneously. The missing gear 6613 drives the gear ring 6513 and the rotating plate 6511 to rotate synchronously, so that the collection bottle 6512 on the rotating plate 6511 rotates to below the collection hole 631. At the same time, the control processor 28 controls the three-way collection valve 291 to start, so that the cerebrospinal fluid in the suction side connecting tube 21 flows into the collection tube 29. At the same time, the drive rod 6611 starts rotating. After rotating and abutting against the liquid dispensing lever 6525, the lever 6525 continues to rotate, causing the liquid dispensing rotating rod 6523 to rotate. The lever 6525 then causes the liquid dispensing cap 6521 to rotate, eventually rotating the cap horizontally to expose the opening of the dispensing bottle 6512. Simultaneously, the main drive gear 6631 drives the driven gear 6632 to rotate, causing the driven gear 6632 to rotate and move upward on the outer wall of the liquid dispensing screw 6531. The upward movement of the driven gear 6632 causes the dispensing block 6532 to move upward, which in turn causes the dispensing bottle 6512 to move upward.

[0047] When the first collection bottle 6512 rotates to below the collection hole 631, the misaligned gear 6613 disengages and idles. When the collection bottle 6512 rises to the required height, the drive gear 6631 disengages and idles. At this time, the rise of the collection bottle 6512 provides rotation space for the horizontal movement of the collection cap 6521. After the first collection bottle 6512 has collected cerebrospinal fluid, as the drive rod 6622 continues to push the collection lever 6525 to rotate, the drive rod 6622 will disengage from the collection lever 6525, so that the collection lever 6525 is subjected to the restoring force of the torsion spring 6524, and finally the collection cap 6521 is reset and placed on the top opening of the collection bottle 6512.

[0048] After the set interval, the drive motor 6611 restarts, allowing the required amount of cerebrospinal fluid to flow into the second collection bottle 6512; then the above operation can be repeated. When it is necessary to test the extracted cerebrospinal fluid, the sampler is removed from the collection tube 29, the box cover 64 and the partition plate 63 are opened, and multiple collection bottles 6512 are taken out and tested according to the labels on the collection bottles 6512; then the new collection bottle 6512 is placed in the box 61.

[0049] The technical effects of this invention are as follows: This cerebrospinal fluid external filtration and dialysis device monitors the pressure and flow rate changes of cerebrospinal fluid through the suction-side pressure sensor 24, the return-side pressure sensor 25, and the flow meter 26. The data is then processed and analyzed by the control processor 28 to adjust the pump speed of the peristaltic pump 30 and the opening and closing of the replenishment valve 271. Cryptococcus, viral pathogens, and brain hemorrhage degradation proteins in the cerebrospinal fluid are filtered out by the filtration dialyzer 40, allowing the purified cerebrospinal fluid to flow back into the ventricles of the brain. Through the coordinated operation of the liquid collection component 65 and the drive component 66, the movement, rising, and opening of the liquid collection bottle 6512 are performed simultaneously, allowing the bottle to collect the required amount of cerebrospinal fluid for subsequent testing.

[0050] The above embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to limit it. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention, and they should all be covered within the scope of the claims and specification of the present invention.

Claims

1. A cerebrospinal fluid external filtration dialysis device, characterized in that, include: The drainage tube is a dual-lumen tube, consisting of an outflow drainage tube and an inflow drainage tube; The filter dialyzer has its inlet and outlet connected by a suction side connecting pipe. The end of the suction side connecting pipe near the filter dialyzer is connected to a liquid collection pipe, which is detachably equipped with a timed liquid collector. A peristaltic pump, wherein the suction-side connecting tube passes through the interior of the peristaltic pump, so that the peristaltic pump is used to power the cerebrospinal fluid inside the suction-side connecting tube; and The liquid storage bag has its inlet connected to the first outlet of the filter dialyzer via a suction connection pipe; the inlet of the drainage inlet pipe is connected to the second outlet of the filter dialyzer via a return-side connection pipe.

2. The cerebrospinal fluid external filtration dialysis device according to claim 1, characterized in that: A suction-side pressure sensor is installed on the suction-side connecting pipe, and a return-side pressure sensor is installed on the return-side connecting pipe. A control processor is installed on the filter dialyzer. Both the suction-side pressure sensor and the return-side pressure sensor are electrically connected to the control processor. The control processor is used to adjust the pump speed of the peristaltic pump and / or the opening and closing of the valve according to the pressure signal.

3. The cerebrospinal fluid external filtration dialysis device according to claim 2, characterized in that: A flow meter is installed on the reinfusion side connection pipe, and the flow meter is electrically connected to the control processor; a replenishment tank is also installed on the reinfusion side connection pipe, which is used to replenish artificial cerebrospinal fluid to the reinfusion side connection pipe.

4. The cerebrospinal fluid external filtration dialysis device according to claim 3, characterized in that: The suction connection pipe is equipped with a diversion valve, and the liquid outlet of the replenishment tank is equipped with a replenishment valve.

5. The cerebrospinal fluid external filtration dialysis device according to claim 1, characterized in that: The filtration dialyzer includes an outer shell and an inner shell. The inner shell is coaxially fitted inside the outer shell. A filter membrane is detachably installed in an opening at the bottom of the inner shell. The outlet end of the suction-side connecting pipe extends through the top of the outer shell to the inner top of the inner shell. The inlet of the return-side connecting pipe is connected to the inner bottom of the outer shell. The suction connecting pipe passes through the side wall of the outer shell and connects to the bottom of the outer wall of the inner shell.

6. The cerebrospinal fluid external filtration dialysis device according to claim 1, characterized in that: The timed liquid dispenser includes a housing with a fixed vertical partition inside. The partition divides the interior of the housing into a liquid dispensing chamber and a driving chamber. The liquid dispensing chamber contains a liquid dispensing component, and the driving chamber contains a driving component. The driving component drives the liquid dispensing component to rotate, so that the cerebrospinal fluid flowing from the liquid dispensing tube flows into different liquid dispensing bottles at regular intervals. A horizontal partition is detachably installed at the top of the liquid dispensing chamber. A liquid dispensing hole is opened on one side of the top of the horizontal partition. The end of the liquid dispensing tube extends through the housing and is inserted into the liquid dispensing hole.

7. The cerebrospinal fluid external filtration dialysis device according to claim 6, characterized in that: The liquid collection assembly includes a rotating plate and multiple liquid collection bottles. The rotating plate is rotatably mounted on the inner bottom wall of the liquid collection chamber, and a toothed ring is fixedly provided on the outer side of the rotating plate. Multiple liquid collection bottles are detachably mounted on the top of the rotating plate along the circumferential direction. The drive assembly includes a drive motor and a rotating shaft. The base of the drive motor is fixedly mounted on the inner bottom wall of the drive cavity. The bottom of the rotating shaft is fixedly connected to the output shaft of the drive motor. The top of the rotating shaft is rotatably connected to the inner top wall of the drive cavity. A missing gear is fixedly sleeved on the bottom of the outer wall of the rotating shaft. The missing gear can mesh with the gear ring. The missing gear is driven to rotate by the timing of the drive motor, so that the missing gear drives the gear ring to rotate by the required angle.

8. The cerebrospinal fluid external filtration dialysis device according to claim 7, characterized in that: The liquid dispensing assembly also includes multiple dispensing caps, a fixing ring, and a dispensing rotating rod. The multiple dispensing caps are rotatably placed on the top opening of the corresponding dispensing bottle. A fixing ring is fixedly provided on the top of the outer wall of the dispensing bottle. The bottom of the dispensing rotating rod is rotatably inserted into the fixing ring. The top of the dispensing rotating rod is fixedly connected to one side of the outer side of the dispensing cap. A torsion spring is sleeved on the outer side of the dispensing rotating rod. One end of the torsion spring is fixedly connected to the outer wall of the dispensing rotating rod, and the other end is fixedly connected to the outer wall of the fixing ring. A dispensing lever is fixedly provided on the top of the dispensing rotating rod. The drive assembly also includes a drive ring, which is fixedly sleeved on the top of the outer wall of the rotating shaft. A drive rod is fixedly connected to one side of the outer surface of the drive ring. The drive rod can abut against the liquid dispensing lever, thereby driving the liquid dispensing lever to rotate the liquid dispensing cover horizontally.

9. The cerebrospinal fluid external filtration dialysis device according to claim 8, characterized in that: The liquid dispensing assembly also includes a liquid dispensing screw and a liquid dispensing block. One end of the liquid dispensing block is fixedly sleeved on the outside of the liquid dispensing bottle, and the other end of the liquid dispensing block is rotatably sleeved on the outside of the liquid dispensing screw. The bottom of the liquid dispensing screw is rotatably connected to the top of the rotating plate. The drive assembly also includes a drive master gear and a drive slave gear. The drive gear is sleeved on the outer wall of the rotating shaft, and the drive slave gear is threaded on the outer wall of the liquid-collecting screw thread rod. The top of the drive slave gear is rotatably connected to the bottom of the other end of the liquid-collecting block, and the drive master gear and the drive slave gear are meshed together.

10. The cerebrospinal fluid external filtration dialysis device according to claim 9, characterized in that: The liquid dispensing assembly also includes multiple elastic blocks. The top of the rotating plate has multiple support grooves along the circumferential direction. The upper side of the elastic block is a rigid silicone block and the lower side is an elastic silicone cover. The elastic silicone cover in the elastic block is fixedly installed on the top opening of the support groove. The top of the rigid silicone block in the elastic block has a fixing groove. The bottom of the liquid dispensing bottle is set in the fixing groove. Each of the multiple support grooves is equipped with a support spring. One end of the support spring is fixedly connected to the inner bottom wall of the support groove, and the other end is fixedly connected to the inner top wall of the rigid silicone block in the elastic block.

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